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Articles 28471 - 28500 of 28519
Full-Text Articles in Entire DC Network
The Legacy Of A Gentleman Scientist: Pierre Hainaut, Christophe Arnoult, Laura D Attardi, Kerem Batsheva, Giovanni Blandino, Kathleen H Burns, Giannino Del Sal, David G Kirsch, David P Lane, Arnold J Levine, Guillermina Lozano, David Malkin, Gerry Melino, Moshe Oren, Carol Prives, Daniel Schramek
The Legacy Of A Gentleman Scientist: Pierre Hainaut, Christophe Arnoult, Laura D Attardi, Kerem Batsheva, Giovanni Blandino, Kathleen H Burns, Giannino Del Sal, David G Kirsch, David P Lane, Arnold J Levine, Guillermina Lozano, David Malkin, Gerry Melino, Moshe Oren, Carol Prives, Daniel Schramek
Faculty, Staff and Student Publications
No abstract provided.
Contemporary Opportunities And Potential Of Auger Electron-Emitting Theranostics, Seok-Yong Lee, H Charles Manning
Contemporary Opportunities And Potential Of Auger Electron-Emitting Theranostics, Seok-Yong Lee, H Charles Manning
Faculty, Staff and Student Publications
Recent breakthroughs in radiopharmaceutical (RP) therapy have emerged interest in employing Auger electron (AE)-emitting radionuclides as potential agents for precise theranostics. AE provides energy with exceptional localization due to their short tissue penetration range (TPR, < 10 nm), rendering them particularly effective for targeting nuclear DNA in tumor cells. In this context, AE-emitting radionuclide therapy (AE-emitting RLT) enables the targeted destruction of tumor cells while reducing harm to adjacent healthy tissue, a significant challenge in this field. Preclinical and early clinical investigations reveal the efficacy of AE-emitting RLTs in the theranostics of diverse malignancies, such as glioblastoma, prostate cancer, and neuroendocrine tumors. Notwithstanding these developments, challenges and limitations persist regarding dosimetry, delivery efficiency, and the treatment of radiotoxicity. A new paradigm is being developed to tackle the obstacles encountered by integrating molecular target markers (e.g., PARP) that function near the nucleus to improve the intranuclear delivery efficiency of AE-emitting radionuclides. Novel radiochemical methods such as these have facilitated the more stable and efficient labeling of biomolecules with AE-emitting radionuclides. Also, recent advances in DNA-molecular targeting, nanoparticles, nucleic acid/protein engineering, click- or bioorthogonal conjugation chemistry, and artificial intelligence (AI)-based structure modeling present concrete opportunities to overcome these limitations. Moreover, the integration of diagnostic imaging companion platforms employing theranostic radioisotope pairings facilitates real-time assessment of therapeutic efficacy and biodistribution, resulting in the formulation of enhanced treatment regimens. This review summarizes the prior development, recent advancements, barriers in clinical implementation, and future perspective of AE-emitting RLTs.
Nsd2 Inhibitors Rewire Chromatin To Treat Lung And Pancreatic Cancers, Jinho Jeong, Simone Hausmann, Hanyang Dong, Kacper Szczepski, Natasha M Flores, Andy Garcia Gonzalez, Liyang Shi, Xiaoyin Lu, Joanna Lempiäinen, Moritz Jakab, Liyong Zeng, Tourkian Chasan, Eric Bareke, Rui Dong, Emma Carlson, Reinnier Padilla, Dylan Husmann, Julia Thompson, Gerry A Shipman, Emily Zahn, Courtney A Barnes, Laiba F Khan, Liz Marie Albertorio-Sáez, Eva Brill, Vishnu Udayakumar Sunita Kumary, Matthew R Marunde, Danielle N Maryanski, Cheryl C Szany, Bryan J Venters, Carolina Lin Windham, Michal Eligiusz Nowakowski, Iwona Czaban, Mariusz Jaremko, Michael-Christopher Keogh, Kang Le, Michael J Soth, Benjamin A Garcia, Łukasz Jaremko, Jacek Majewski, Pawel K Mazur, Or Gozani
Nsd2 Inhibitors Rewire Chromatin To Treat Lung And Pancreatic Cancers, Jinho Jeong, Simone Hausmann, Hanyang Dong, Kacper Szczepski, Natasha M Flores, Andy Garcia Gonzalez, Liyang Shi, Xiaoyin Lu, Joanna Lempiäinen, Moritz Jakab, Liyong Zeng, Tourkian Chasan, Eric Bareke, Rui Dong, Emma Carlson, Reinnier Padilla, Dylan Husmann, Julia Thompson, Gerry A Shipman, Emily Zahn, Courtney A Barnes, Laiba F Khan, Liz Marie Albertorio-Sáez, Eva Brill, Vishnu Udayakumar Sunita Kumary, Matthew R Marunde, Danielle N Maryanski, Cheryl C Szany, Bryan J Venters, Carolina Lin Windham, Michal Eligiusz Nowakowski, Iwona Czaban, Mariusz Jaremko, Michael-Christopher Keogh, Kang Le, Michael J Soth, Benjamin A Garcia, Łukasz Jaremko, Jacek Majewski, Pawel K Mazur, Or Gozani
Faculty, Staff and Student Publications
NSD2 catalyses the epigenetic modification H3K36me2 (refs. 1,2) and is a candidate convergent downstream effector of oncogenic signalling in diverse malignancies3–5. However, it remains unclear whether the enzymatic activity of NSD2 is therapeutically targetable. Here we characterize a series of clinical-grade small-molecule catalytic NSD2 inhibitors (NSD2i) and show that the pharmacological targeting of NSD2 constitutes an epigenetic dependency with broad therapeutic efficacy in KRAS-driven preclinical cancer models. NSD2i inhibits NSD2 with single-digit nanomolar half-maximal inhibitory concentration potency and high selectivity over related methyltransferases. Structural analyses reveal that the specificity of NSD2i for NSD2 …
Respiratory Motion Effects And Plan Robustness For Lattice Radiation Therapy, Rachael M Martin-Paulpeter, Peter A Balter, Luis A Perles, Ethan B Ludmir, Joshua S Niedzielski
Respiratory Motion Effects And Plan Robustness For Lattice Radiation Therapy, Rachael M Martin-Paulpeter, Peter A Balter, Luis A Perles, Ethan B Ludmir, Joshua S Niedzielski
Faculty, Staff and Student Publications
Introduction: Lattice radiation therapy (LRT), a form of spatially fractionated radiation therapy (SFRT), has shown promise in treating bulky tumors. It consists of hot and cold spots within the tumor, and the ratio between these doses is thought to be important in clinical outcomes. Respiratory motion is expected to degrade these peak-to-valley dose ratios (PVDRs) but has largely been ignored in LRT literature and clinical practice. This work aims to quantify the response of LRT dose distributions to motion to better inform motion management decisions and improve clinical outcomes.
Methods: Respiratory motion of peak-to-peak amplitudes from 0.3 to 2 cm …
Freeze-Dried, Not Frozen: Lyophilized Mesenchymal Stromal Cell-Derived Extracellular Vesicles And Therapeutic Function In Neuroinflammatory Models, Janet R Ashley, Aidan M Collier, Scott D Olson, Charles S Cox
Freeze-Dried, Not Frozen: Lyophilized Mesenchymal Stromal Cell-Derived Extracellular Vesicles And Therapeutic Function In Neuroinflammatory Models, Janet R Ashley, Aidan M Collier, Scott D Olson, Charles S Cox
Faculty, Staff and Student Publications
Background: Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) offer a promising acellular therapy for immune modulation, but clinical translation is hindered by variability and storage constraints. Lyophilization (freeze-drying) could enable shelf-stable EV therapeutics, although its effects on biological activity remain incompletely defined.
Study design: We compared the immunomodulatory effects of frozen and lyophilized EVs from bone marrow (BM), adipose tissue (AD), and umbilical cord (UC) MSCs using lipopolysaccharide-stimulated rodent splenocytes and microglial models and human peripheral blood mononuclear cells (PBMCs). Variables included batch scale (small vs large), cytokine priming, and MSC source. Tumor necrosis factor alpha (TNF-α) secretion was measured …
Single-Cell Lineage Trajectory Defines Cyclin-Dependent Kinase Inhibitor-Sensitive Cells-Of-Origin In Esophageal Squamous Cell Carcinoma, Kyung-Pil Ko, Jie Zhang, Sohee Jun, Jae-Il Park
Single-Cell Lineage Trajectory Defines Cyclin-Dependent Kinase Inhibitor-Sensitive Cells-Of-Origin In Esophageal Squamous Cell Carcinoma, Kyung-Pil Ko, Jie Zhang, Sohee Jun, Jae-Il Park
Faculty, Staff and Student Publications
Background and aims: Understanding the cells of origin is essential for overcoming therapy resistance and improving early intervention strategies in esophageal squamous cell carcinoma (ESCC). Despite recent advances in genomic profiling, the precise cellular hierarchies and molecular programs driving ESCC initiation remain poorly defined.
Methods: We utilized machine learning-based single-cell trajectory analysis on 4-nitroquinoline 1-oxide-induced murine models and genetically engineered organoids to identify cellular lineages during tumorigenesis. Combined with gene regulatory network analysis, we identified transcriptional drivers of tumor initiation and employed transcriptome-based drug repurposing to predict compounds targeting these initiating populations.
Results: Our analyses revealed multiple distinct epithelial clusters …
Key Regulatory Roles Of Prdm1 In Human Nk-Cell Differentiation And Activation, Xuxiang Liu, Yunfei Shi, Jibin Zhang, Kunal Shetty, Krystie Chew, Can Küçük, Qiang Gong, Esra Esmeray, Haiqing Li, Ru Chen, Sheng Pan, Katarzyna Dąbrowska, Roger E Moore, Krystine Garcia-Mansfield, Patrick Pirrotte, Jinhui Wang, Yuping Li, Gehong Dong, Logan Lee, Timothy W Mckeithan, Javeed Iqbal, Wing C Chan
Key Regulatory Roles Of Prdm1 In Human Nk-Cell Differentiation And Activation, Xuxiang Liu, Yunfei Shi, Jibin Zhang, Kunal Shetty, Krystie Chew, Can Küçük, Qiang Gong, Esra Esmeray, Haiqing Li, Ru Chen, Sheng Pan, Katarzyna Dąbrowska, Roger E Moore, Krystine Garcia-Mansfield, Patrick Pirrotte, Jinhui Wang, Yuping Li, Gehong Dong, Logan Lee, Timothy W Mckeithan, Javeed Iqbal, Wing C Chan
Faculty, Staff and Student Publications
PRDM1, encoding a transcription factor (TF), regulates plasma cell and CD8+ T-cell terminal differentiation and Th2 lineage specification, while its role in human NK-cell differentiation and homeostasis is largely unknown. Here, we employed a multi-omics approach to dissect the transcriptional control of PRDM1 on human NK-cells. PRDM1 is important in NK-cell terminal differentiation based on gene expression profiling and its targeting of key regulators in the process. PRDM1-deleted NK-cells displayed a less mature phenotype simulating the CD56bright NK-cell population accompanied by upregulation of stem-like gene signatures. PRDM1-bound genes were enriched in T/NK-cell receptor signaling, activation, and NK-cell effector …
Grading Melanocytic Dysplasia: Updated Histopathologic Criteria, Christopher R Shea, Victor G Prieto, Catherine M Shachaf, Scott R Florell
Grading Melanocytic Dysplasia: Updated Histopathologic Criteria, Christopher R Shea, Victor G Prieto, Catherine M Shachaf, Scott R Florell
Faculty, Staff and Student Publications
Dr. Martin C. Mihm, Jr.'s innovative work on the dysplastic nevus achieved a milestone in his chapter in the World Health Organisation Classification of Skin Tumours (WHO-C). WHO-C presents a dichotomous classification (high-grade versus low-grade dysplastic nevi) and a quantitative metric to assess melanocytic nuclear enlargement. The Duke classification is a related approach that provides mostly quantitative histopathologic criteria for dysplastic nevi and gives due weight to architectural features as well as cytology. This paper proposes and illustrates updated criteria for scoring and grading melanocytic dysplasia, incorporating some of the definitions and categories of WHO-C, while refining the quantitative and …
Evaluation Of Organ-Specific Relative Biological Effectiveness Of Proton Therapy Using Radiation-Induced Pneumonitis As An Endpoint, Li Liao, Ting Xu, Mei Chen, Tingshi Su, Narayan Sahoo, Xiaorong Zhu, Steven J Frank, Quynh-Nhu Nguyen, Zhongxing Liao, Xiaodong Zhang
Evaluation Of Organ-Specific Relative Biological Effectiveness Of Proton Therapy Using Radiation-Induced Pneumonitis As An Endpoint, Li Liao, Ting Xu, Mei Chen, Tingshi Su, Narayan Sahoo, Xiaorong Zhu, Steven J Frank, Quynh-Nhu Nguyen, Zhongxing Liao, Xiaodong Zhang
Faculty, Staff and Student Publications
Background and purpose: Proton therapy has become widely used for non-small cell lung cancer (NSCLC) due to its ability to spare normal tissue. However, the commonly assumed relative biological effectiveness (RBE) of 1.1 may underestimate the therapy's true biological effects on lung, potentially leading to a higher than expected incidence of radiation-induced pneumonitis (RP). In this retrospective study, we evaluated the variability of organ-specific RBE of proton therapy using RP grade 2 or higher (RP2+) as an endpoint.
Materials and methods: Data from 270 NSCLC patients across two clinical trials were analyzed, with 134 given photon therapy and 136 given …
Trial Interviews To Explore Glycogen Storage Disease Type Ia Patient Experiences Following Gene Therapy, Diane M Turner-Bowker, Jessica Butler, Shayna Egan, David A Weinstein, David F Rodriguez-Buritica, Ayesha Ahmad, María-Luz Couce, Rebecca Riba-Wolman, John J Mitchell, Christina Theodore-Oklota
Trial Interviews To Explore Glycogen Storage Disease Type Ia Patient Experiences Following Gene Therapy, Diane M Turner-Bowker, Jessica Butler, Shayna Egan, David A Weinstein, David F Rodriguez-Buritica, Ayesha Ahmad, María-Luz Couce, Rebecca Riba-Wolman, John J Mitchell, Christina Theodore-Oklota
Faculty, Staff and Student Publications
Background: Glycogen storage disease type Ia (GSDIa) is a rare, inherited, autosomal recessive deficiency of glucose-6-phosphatase (G6Pase), an enzyme necessary in glycogenolysis and gluconeogenesis. To maintain normal blood glucose levels and ensure survival, individuals living with GSDIa must frequently consume complex carbohydrates (eg, uncooked cornstarch). Dietary management can result in chronic complications and significant patient burden. DTX401 (pariglasgene brecaparvovec) is an investigational adeno-associated virus serotype 8 vector (AAV8)-based gene therapy designed to restore endogenous glucose production.
Objectives: Patient experience interviews were conducted as part of an open-label, phase 1/2 dose-escalation trial (NCT03517085) evaluating the safety and efficacy of …
Dietetic Guidance For Nutritional Management Of People With Phenylketonuria Receiving Sepiapterin, Anita Macdonald, Kirsten Ahring, Alexa Bledsoe, Hiroki Fujimoto, Sara Giorda, Christian Kogelmann, Jessica Kopesky, Laura Nagy, Sara O'Neill, Alex Pinto, Soraia Poloni, Paige Roberts, Annemiek M J Van Wegberg, Suzanne Hollander
Dietetic Guidance For Nutritional Management Of People With Phenylketonuria Receiving Sepiapterin, Anita Macdonald, Kirsten Ahring, Alexa Bledsoe, Hiroki Fujimoto, Sara Giorda, Christian Kogelmann, Jessica Kopesky, Laura Nagy, Sara O'Neill, Alex Pinto, Soraia Poloni, Paige Roberts, Annemiek M J Van Wegberg, Suzanne Hollander
Faculty, Staff and Student Publications
Background/objectives: Phenylketonuria (PKU) is an autosomal recessive inborn error of metabolism. If untreated, elevated blood phenylalanine (Phe) levels lead to neurological and behavioral impairments. Phe levels can be managed through a lifelong Phe-restricted diet; however, this can be challenging to maintain. Sepiapterin is an adjunct therapy for PKU that has shown efficacy in reducing blood Phe levels in both tetrahydrobiopterin (BH4)-responsive and BH4-non-responsive people with PKU in clinical trials. Practical guidance is needed for dietitians and other healthcare professionals supporting the dietary management of people with PKU who are initiating or receiving sepiapterin.
Methods: A group of international dietitians participated …
Review Of 'The Royal Musical Association: Creating Scholars, Advancing Research' By Leanne Langley, Nuria Bonet
Review Of 'The Royal Musical Association: Creating Scholars, Advancing Research' By Leanne Langley, Nuria Bonet
School of Art, Design and Architecture
No abstract provided.
Presence And Characteristics Of Plastics And Microplastics On The Seabed Of The Western English Channel, Faye Read, Andrew Turner
Presence And Characteristics Of Plastics And Microplastics On The Seabed Of The Western English Channel, Faye Read, Andrew Turner
School of Geography, Earth and Environmental Sciences
Little is known about the presence, distribution, origins and characteristics of plastic litter and microplastics on the ocean floor. In this study, plastics trawled from the bed of the western English Channel have been categorised and analysed by a variety of optical and spectroscopic techniques. A total of 90 plastic samples were classified, in descending order of abundance, as food-drink packaging, unknown, homeware, military and fishing. Most samples showed varying degrees of weathering (e.g., discolouration, distortion, cracking, fragmentation) and were visibly fouled by calcareous deposits. The majority of samples were constructed of polymers of negative buoyancy (e.g., polyamides, polyethylene terephthalate …
Planetarity And Relation: Ecology As Method, Ashish Ghadiali
Planetarity And Relation: Ecology As Method, Ashish Ghadiali
School of Art, Design and Architecture Theses
The List of Works submitted comprises research through film, text, exhibition, performance and policy engagement, developed during a three-year period from 2021 to 2024 in the site-specific location of Southwest England. This multi-modal and interdisciplinary practice is framed in response to the question of how art and cultural strategy can, in the contexts of climate breakdown and global racial inequity, be conceived of as agency for environmental justice. In this integrative summary, I present a theoretical framework where ecology, in response to conditions of environmental crisis, is understood not only as a subject of inquiry but also as method. In …
Feminism, Domestic Abuse And The Singer-Songwriter, Kathryn Ferguson
Feminism, Domestic Abuse And The Singer-Songwriter, Kathryn Ferguson
School of Art, Design and Architecture Theses
This project explores how feminism and domestic abuse can be articulatedthrough songwriting. Research in music therapy, sociology and popular musicincreasingly speaks to the value of songwriting as a tool for personal andcommunity empowerment, but there is space to actively use songwriting toexplore feminist issues independently of the traditional commercial context ofpopular music. Existing feminist music has been deemed as at its mostsuccessful when it is linked clearly to social change in our communities(Greene, 2017, p.8). Modern popular feminist songwriting has been criticised fornot going far enough in deconstructing systemic patterns of patriarchy (Tong,2024, p.9). Considering this, engaging with academic research …
Analysis Of Volatility Between Macroeconomic Variables And Busan Port Cargo Throughput According To Global Risks, Sang Ho Cho
Analysis Of Volatility Between Macroeconomic Variables And Busan Port Cargo Throughput According To Global Risks, Sang Ho Cho
Plymouth Business School Theses
This study investigates how container (BPC) and non-container (BPB) cargo throughput at Busan Port responds to structural shocks in global and domestic macroeconomic variables, and how their relative importance changes over time. The selection of variables was based on a combination of a Systematic Literature Review (SLR) and semi-structured interviews (SSI). The econometric analysis applied a stepwise framework, employing cumulative Impulse Response Functions (IRF) and Forecast Error Variance Decomposition (FEVD) based on Vector Error Correction Model (VECM) estimations, as well as Historical Decomposition (HD) for specific crisis periods. While IRF and FEVD were used to capture dynamic properties under general …
Using Data To Identify Gaps And Improve Institutional Collecting In Public University Archives, Hannah Pryor
Using Data To Identify Gaps And Improve Institutional Collecting In Public University Archives, Hannah Pryor
Faculty and Staff Scholarship
This article describes a project undertaken to assess the university records held by Archives & Special Collections at the University of Louisville. The intention was to identify potential gaps in permanent university records and other university records that fall under relevant collection policies, such as those documenting faculty, staff, and student life. This project included generating a report of accession records in ArchivesSpace, conducting data cleanup, coding qualitative data, creating visualizations, and analyzing findings, with the aim of prioritizing outreach to university units and assisting with future backlog processing and reappraisal. The findings identify ways to improve records management and …
Words That Heal Or Harm: A Narrative Review On Language Use In Nursing Care.", R. Sudha, A.S. Neya
Words That Heal Or Harm: A Narrative Review On Language Use In Nursing Care.", R. Sudha, A.S. Neya
Manipal Journal of Nursing and Health Sciences
No abstract provided.
Challenges In Implementing Digital Health Solutions For Pressure Ulcer Management: A Narrative Review, Shreenidhi Jogi, Elsa Sanatombi Devi, Vishal Shanbhag
Challenges In Implementing Digital Health Solutions For Pressure Ulcer Management: A Narrative Review, Shreenidhi Jogi, Elsa Sanatombi Devi, Vishal Shanbhag
Manipal Journal of Nursing and Health Sciences
Background: Digital pressure ulcer care solutions are both accurate and well-developed in terms of technology. However, a gap remains between available digital solutions and their use in everyday pressure ulcer care practices. This review aims to summarize the technical, human, and system-level challenges that restrict the effective application of digital health solutions in pressure ulcer management.
Methods: The search was conducted in CINAHL, PubMed, Scopus, Web of Science, and EMBASE. Studies that reported implementation challenges in their findings were included.
Results: Infrastructure barriers were about more than just having internet access. Issues such as inconsistent system performance and hardware malfunctions …
How Do Students Come Across Occupational Therapy And What Makes Them Want To Study Occupational Therapy? Implications For Recruitment, Mette Eg Bruun, Mette Krohn, Sofie Balle Riis, Lene Tanggaard, Tina Helle
How Do Students Come Across Occupational Therapy And What Makes Them Want To Study Occupational Therapy? Implications For Recruitment, Mette Eg Bruun, Mette Krohn, Sofie Balle Riis, Lene Tanggaard, Tina Helle
Journal of Occupational Therapy Education
Recruitment challenges in occupational therapy education vary globally. To address workforce needs, it is necessary to examine the factors influencing students’ decisions to pursue occupational therapy. This study investigated how students discovered occupational therapy, what they found appealing about the profession, the influence of study location, and demographic differences between students enrolled in an urban university city and a rural district. Three focus group interviews with 15 occupational therapy students were conducted, supplemented by descriptive statistics comparing student characteristics across urban and rural programs. Qualitative analysis identified five categories: (1) discovering occupational therapy by chance, (2) the power of occupational …
Perceived Impacts Of Confucianism On Placement Experiences Of Hong Kong Pre-Registration Occupational Therapy Students In The United Kingdom, Hin Yuet Li, Sarah Louise Mcginley, Rachel Dadswell, Rachel Houweling
Perceived Impacts Of Confucianism On Placement Experiences Of Hong Kong Pre-Registration Occupational Therapy Students In The United Kingdom, Hin Yuet Li, Sarah Louise Mcginley, Rachel Dadswell, Rachel Houweling
Journal of Occupational Therapy Education
This study explored the views of Hong Kong pre-registration occupational therapy (OT) students in the United Kingdom (UK) about how Chinese culture influenced their practice placement experiences. Students from diverse cultural backgrounds may encounter various challenges during OT placements, but little is known about how OT students from Hong Kong—where Confucianism traditionally shapes workplace expectations and the hierarchical teacher‑student relationship—experience placements in the UK. Two online focus groups to collect qualitative data were conducted in November 2022 with four participants who were UK-based OT students from Hong Kong (N=8 in total), two facilitators (OT students from Hong Kong, based in …
Examining The Relationship Between Musculoskeletal Knowledge And Fieldwork Performance Among Canadian Student Occupational Therapists, Madelyn Walther, Viansa Guiotto, Rhona Anderson, Emily S. Ho
Examining The Relationship Between Musculoskeletal Knowledge And Fieldwork Performance Among Canadian Student Occupational Therapists, Madelyn Walther, Viansa Guiotto, Rhona Anderson, Emily S. Ho
Journal of Occupational Therapy Education
To evaluate the physical aspects of occupational performance, occupational therapists must understand the anatomical structure and function of the body. As such, occupational therapy academic programs must provide sufficient foundational musculoskeletal (MSK) education to prepare student occupational therapists for successful clinical practice. There is a paucity of research on MSK educational needs, and the relationship between student occupational therapists’ MSK academic outcomes and fieldwork performance. This study examined the relationship between MSK anatomy course academic grades and fieldwork performance indicators on the Competency-Based Fieldwork Evaluation for Occupational Therapists (CBFE-OT) of student occupational therapists. A mixed-methods sequential explanatory design was conducted …
Generative Artificial Intelligence Application In Occupational Therapy Education, James Wersal, Justin Mason, Mary Shotwell
Generative Artificial Intelligence Application In Occupational Therapy Education, James Wersal, Justin Mason, Mary Shotwell
Journal of Occupational Therapy Education
Generative artificial intelligence (GenAI) is a developing technology within Higher Education Institutions with substantial potential to transform teaching pedagogy, improve individualized learning experiences, and automate administrative functions. GenAI has the potential to bring significant enhancements by advancing adaptive learning interfaces, customized learning materials, and automate administrative support. Despite these benefits, ethical considerations, data privacy, and the risk of over-reliance should be considered prior to using GenAI. The authors highlight how GenAI is supported by adult learning theory and provide practical strategies for incorporating GenAI in the occupational therapy curricula and to support the faculty role. The impact of GenAI on …
Entry Requirements As Predictors Of Early Academic Success And Student Performance In Undergraduate Occupational Therapy Education, Eileen Du Plooy, Daleen Casteleijn, Denise Franzsen, Gopika Ramkilawon
Entry Requirements As Predictors Of Early Academic Success And Student Performance In Undergraduate Occupational Therapy Education, Eileen Du Plooy, Daleen Casteleijn, Denise Franzsen, Gopika Ramkilawon
Journal of Occupational Therapy Education
The selection process for health sciences programs such as occupational therapy is complex, involving a combination of academic and non-academic selection criteria as entry requirements. This study aimed to investigate the predictive value of entry requirement variables on academic performance during the first and second year of an undergraduate occupational therapy program in South Africa. A quantitative, cross-sectional design was utilized, and the sample included 129 first- and second- year occupational therapy students. Data was collected retrospectively through educational data mining of university records and institutional dashboards. The variables analyzed included National Senior Certificate Grade12 (NSC12) grades (Mathematics, Life Sciences, …
Attribution Theory In Occupational Therapy Clinical Education: A Scoping Review, Julia Shin, Anna Domina, Ashley Fecht, Lisa Bagby, Raigan Borsh
Attribution Theory In Occupational Therapy Clinical Education: A Scoping Review, Julia Shin, Anna Domina, Ashley Fecht, Lisa Bagby, Raigan Borsh
Journal of Occupational Therapy Education
Intrapersonal and interpersonal skills are essential for occupational therapy students’ professional development and fieldwork success. Despite their importance, these competencies are often ambiguously defined, inconsistently assessed, and underemphasized in curricula. Attribution theory, a well-established framework from social psychology, provides a valuable lens for examining how students’ causal attributions influence their motivation, behavior, and professional growth. This scoping review aimed to synthesize the application of attribution theory in health professions education by characterizing attribution-focused interventions, assessments, and student outcomes. Following Arksey and O’Malley’s (2005) five-stage framework and PRISMA-ScR guidelines, we conducted systematic searches across Academic Premier, CINAHL, ERIC, OTSeeker, and PubMed …
Exploring Microaggressions Experienced By Students Of Color In Occupational Therapy Programs: Fostering A Climate Of Belonging, Laurie Knis-Matthews Ph.D., Ot, Sara Frommer Otd, Otr/L, Jacquelyn Pierre Otd, Otr/L, Geena Santomo Otd, Otr/L, Corrine Pineda Msot, Otr/L, Jackeline Artiles Otd, Shaniqua Bradley Ph.D., Lcsw
Exploring Microaggressions Experienced By Students Of Color In Occupational Therapy Programs: Fostering A Climate Of Belonging, Laurie Knis-Matthews Ph.D., Ot, Sara Frommer Otd, Otr/L, Jacquelyn Pierre Otd, Otr/L, Geena Santomo Otd, Otr/L, Corrine Pineda Msot, Otr/L, Jackeline Artiles Otd, Shaniqua Bradley Ph.D., Lcsw
Journal of Occupational Therapy Education
Microaggressions, which are subtle and often unintentional acts of bias, continue to shape the educational experiences of students from marginalized backgrounds, yet their nuanced nature makes them difficult to define and address. This phenomenological qualitative study investigated the lived experiences of occupational therapy graduate students of color regarding microaggressions within their academic programs. Using purposeful sampling, five occupational therapy graduate students from various United States institutions participated in individual, semi-structured interviews. Thematic analysis revealed four key themes: It’s Hard to Describe a Microaggression without Using Examples and Explaining the Emotions Behind It; These Microaggressions Had Immediate and Long-Term Consequences on …
Change In Perception Of Cultural Self-Efficacy Among Graduate Students In An Occupational Therapy Academic Program, Emma Edwards, Selena E. Washington, Zidong Zhang
Change In Perception Of Cultural Self-Efficacy Among Graduate Students In An Occupational Therapy Academic Program, Emma Edwards, Selena E. Washington, Zidong Zhang
Journal of Occupational Therapy Education
Culturally responsive care is essential to improving healthcare access and outcomes; however, the extent to which occupational therapy students are prepared to deliver such care remains unclear. Experiential learning embedded within occupational therapy curricula, including fieldwork, is considered a key pathway for developing cultural self-efficacy. This quantitative study examined changes in cultural self-efficacy among graduate occupational therapy students across didactic and experiential learning experiences within a Master of Occupational Therapy program. Using the Multidisciplinary Healthcare Provider version of the Transcultural Self-Efficacy Tool, perceived self-efficacy across the cognitive, practical, and affective domains was assessed across three cohort-based administration periods aligned with …
Assessing Supports And Barriers To Equitable Participation In Occupational Therapy Fieldwork For Students From Minoritized Backgrounds: A Mixed Methods Analysis, Kristin M. Nxumalo, Coalition Of Occupational Therapy Advocates For Diversity Cotad, Alexia Rebne, Janis Yue, Ryan Thomure, Ricardo D. Ramirez
Assessing Supports And Barriers To Equitable Participation In Occupational Therapy Fieldwork For Students From Minoritized Backgrounds: A Mixed Methods Analysis, Kristin M. Nxumalo, Coalition Of Occupational Therapy Advocates For Diversity Cotad, Alexia Rebne, Janis Yue, Ryan Thomure, Ricardo D. Ramirez
Journal of Occupational Therapy Education
Fieldwork experiences in occupational therapy (OT) and occupational therapy assistant (OTA) education introduce students to novel environments that they must successfully navigate. When examining the experiences of OT and OTA students from minoritized backgrounds, it is critical to understand their fieldwork experiences so that fieldwork educators and partners can create inclusive, supportive environments that promote success for all students. Within this study, a needs assessment was conducted to explore factors that impacted the OT and OTA fieldwork experiences of students from minoritized backgrounds. Using a mixed methods design, a cross-sectional survey was completed by non-faculty OT practitioners (n=48), Academic Fieldwork …
Development Of Soft Skills In Occupational Therapy Education: A Faculty Perspective, John Adkins, Alysha Skuthan
Development Of Soft Skills In Occupational Therapy Education: A Faculty Perspective, John Adkins, Alysha Skuthan
Journal of Occupational Therapy Education
Soft skills, such as communication, emotional intelligence, and response to feedback, are critical for the success of occupational therapy students but are often underemphasized in educational standards and curricula. This qualitative study examined how faculty perceived, defined, and facilitated the development of soft skills during the didactic phase of occupational therapy education. Using a phenomenological design, 12 faculty members from accredited occupational therapy programs participated in semi-structured interviews. Thematic analysis revealed six themes: Hidden Skills, Incorrect Assumptions, and What’s Trending addressed faculty perceptions, while What’s Developing, What’s On Us, and Why Does It Matter described faculty responsibilities and strategies to …
Using Video Analysis To Support Development Of Therapeutic Use Of Self In Occupational Therapy Education, Cynthia L. Selim, Katharine A. Ricks
Using Video Analysis To Support Development Of Therapeutic Use Of Self In Occupational Therapy Education, Cynthia L. Selim, Katharine A. Ricks
Journal of Occupational Therapy Education
Despite recognition of the importance of therapeutic use of self, there remains limited research on effective, evidence-informed approaches within occupational therapy education. Video analysis has emerged as a method to enhance students’ critical thinking, interpersonal communication, and observation skills, however, its direct impact on therapeutic use of self has not been examined. This study evaluated the effectiveness of structured video analysis assignments in improving occupational therapy students’ self‑efficacy for therapeutic use of self and explored student perceptions of the learning experience. Two cohorts of first-year occupational therapy students (n=62) participated in a 10-week course based on the Intentional Relationship Model …