Digital Commons Network^™

Dietrich Von Bern’S Captivity Among Monsters: A Heroic Motif And Its Variations In Waldere, Virginal, Sigenot, And Laurin, Jonathan Seelye Martin

Faculty Publications – Languages, Literatures, and Cultures

No abstract provided.

Retrospective Longitudinal Analysis Of Blood Microrna-7-5p As A Possible Progression Biomarker In People With Parkinson’S Disease, Shayan Abdollah Zadegan, Corrine Hutchinson, Chiamaka Onuigbo, Juan D Martinez-Lemus, Laura Talbot, E Jeffrey Metter, Marie-Francoise Doursout, Emily Tharp, Jessika Suescun, Mohammad Shahnawaz, Timothy M Ellmore, Mya Schiess, Christopher Adams

Faculty, Staff and Student Publications

Background: MicroRNA-7-5p (miR-7-5p) may play a neuroprotective role in people with Parkinson's disease (PwP), as it has been found to regulate α-synuclein (α-syn) and the NLRP3 inflammasome in animal models of Parkinson's disease (PD).

Objective: The study aimed to investigate the use of miR-7-5p as a potential biomarker for disease progression in PwP by correlating it with time, clinical measures, and neurofilament light chain (NfL).

Methods: We performed a longitudinal retrospective analysis of blood miR-7-5p levels in 303 de novo PwP and 159 healthy controls (HCs) from the Parkinson's Progression Markers Initiative (PPMI) cohort. In PwP, a linear mixed-effects …

Defining Large Core Infarction: Comparing The Accuracy Of Non-Contrast Ct Aspects Versus Ct Perfusion Core Volume, Ngoc Mai Le, Joseph Samaha, Ananya S Iyyangar, Javier Gomez-Farias, Bruna Kfoury, Ritesh Bajaj, Connor Nguyen, Syed Shams, Camille Neal-Harris, Emmanuel Ebirim, Hussain Azeem, Anjan N Ballekere, Saagar Dhanjani, Eunyoung Lee, Luca Giancardo, Sunil A Sheth

Faculty, Staff and Student Publications

Background and purpose: We evaluated agreement and performance of non-contrast head-computerized tomography (NCHCT) and CT-perfusion (CTP) in identifying large core infarct in acute ischemic stroke (AIS) due to large vessel occlusion (LVO) undergoing endovascular therapy (EVT), using MRI as reference.

Methods: From our prospective multicenter registry, we identified patients with LVO-AIS due to internal carotid artery or middle cerebral artery M1occlusions who underwent EVT between 2017 and 2024. Final infarct volume (FIV) was defined using 24-48 h post-EVT diffusion-weighted imaging magnetic resonance imaging (MRI-FIV). To limit infarct growth bias, only patients with CTP-to-EVT start time < 3 h were included. Large core infarct was defined at FIV thresholds: 50, 70, and 100 mL. The primary outcome was agreement between NCHCT and CTP in identifying large core infarct using kappa-statistics. Large core was considered if NCHCT-ASPECTS< 6 or rCBF< 30% volume>70 mL on CTP (RAPID/Viz.AI). …

Cesarean Section Rates In Lucas Do Rio Verde, Brazil: Assessing The Impact Of Socioeconomic Status And Maternal And Neonatal Outcomes, Ramya Vemulapalli, Roni Arienti, Linder Wendt, Jay Brooks Jackson, Mary B Rysavy, Kimberly A Kenne

Faculty, Staff and Student Publications

Background

Brazil is globally known for its high rate of cesarean section despite endorsing the WHO’s current recommendation of 15%.

Objectives

Determine if socioeconomic status correlated with the rate of cesarean section (CS) at a mixed private and public hospital in the west-central region of Brazil. Describe the maternal and neonatal outcomes by mode of delivery (MOD) in the same population.

Design

Cohort study

Methods

Data from all delivering patients at São Lucas Hospital were collected during an 18-month period and analyzed. Demographics, baseline maternal health status, pregnancy and delivery information, maternal outcomes, and neonatal outcomes were entered into a …

Congenital Syphilis: From Near-Elimination To Crisis, Chad J Abresch, Irene A Stafford, Regan M Johnson, Kayode Olabanji, Ashleigh M Sutphen, Helen E Cejtin, Ashley Hoover

Faculty, Staff and Student Publications

This analytic essay examines the transformation of congenital syphilis (CS) in the United States from near-elimination to crisis. Drawing from the January 2025 Congenital Syphilis Summit in Atlanta, Georgia-convening public health leaders, Tribal health departments, the National Coalition of STD Directors, and Centers for Disease Control and Prevention experts-we contrast prevention systems during near-elimination (1998-2005) with the current crisis (2018-2025). Evidence revealed how dismantling public health infrastructure produced dramatically different outcomes, with CS cases increasing 937% over the past decade and racial/ethnic disparities worsening. American Indian/Alaska Native communities face rates up to 100 times higher than White populations in some …

Sickle Cell Crisis-Induced Painless Bilateral Orbital Bone Infarction: A Case Report, Luke Farson, Marina Shenouda, Agni Kakouri, Ashkan Kashanchi, Clark Sitton, Timothy Mcculley, Ying Chen

Faculty, Staff and Student Publications

Introduction: Sickle cell disease is associated with painful vaso-occlusive crises, bone infarction, avascular necrosis, and osteomyelitis. Sickle cell orbitopathy is a rare manifestation with signs similar to periorbital cellulitis and has subtle radiologic features.

Case presentation: We report a case of a five-year-old girl with sickle cell who presented with bilateral orbital infarctions and subperiosteal hematomas, notably without periorbital pain, and was treated with antibiotics and steroids.

Conclusion: Physicians should be aware of this rare manifestation, especially in the pediatric population, as it can affect subsequent management.

Glaucoma Risk With Metformin And Sulfonylurea Therapies In Type 2 Diabetes: A Retrospective Cohort Study., Jared Lim, Jingru Zhou, Hulin Wu, Ziqi Liu, David A Lee

Faculty, Staff and Student Publications

Background: Research on metformin, sulfonylureas, and open-angle glaucoma risk in type 2 diabetes mellitus (T2DM) has yielded inconsistent findings. This study examined associations between hypoglycemic treatments and glaucoma diagnosis rates.

Methods: This retrospective cohort study analyzed electronic health records of newly diagnosed T2DM patients from the Merative™ Explorys® Therapeutic Dataset (2010-2022), comparing three groups: metformin monotherapy, sulfonylureas plus metformin combination, and untreated controls. Propensity score matching balanced demographics, glycemic control, body mass index, blood pressure, lipid levels, and comorbidities. Cox proportional hazards models calculated adjusted hazard ratios for incident glaucoma.

Results: After 1:1 propensity score matching, metformin monotherapy (N=100,387) showed …

Fostering Connection And Shame Resilience Through Self-Compassion: An Innovative Elective For Health Professions Learners, Gioconda Mojica, Peggy Hsieh, Andrew J Revell, Rex Marco

Faculty, Staff and Student Publications

Background: Shame is an emotional experience in health professions education, often contributing to burnout, isolation, and threats to professional identity. Self-compassion has been identified as a protective factor against shame. This study describes the development and evaluation of an elective designed to foster shame resilience and cultivate self-compassion among health professions students.

Methods: A 6-h elective, Fostering Connection and Shame Resilience Through Self-Compassion, was offered over 3 monthly 2-h sessions. Each session included a shared meal, abbreviated large-group conceptual learning, reflective writing, guided self-compassion practices, and small-group discussions. Participants completed the Self-Compassion Scale-Short Form (SCS-SF) at the beginning and …

Biomechanical And Computational Modeling Of Metastatic Acetabular Defects: Influence Of Tumor Location On The Risk Of Fracture, Jacob Doddridge, Hongjia He, Rui Yang, E U Conrad, Nicholas Dunbar

Faculty, Staff and Student Publications

Background: Metastatic bone disease can lead to pathologic fracture of the pelvis which affects quality of life. There are limited validated approaches for biomechanical modeling, classification, or surgical treatment of metastatic acetabular defects.

Methods: An artificial hemipelvis bone was used to calibrate a computed tomography-based computational model of the pelvis with varying locations and sizes of acetabular defects. Metastatic defects affecting the anterior and posterior column, medial wall, and their combinations were created. Mechanical testing was performed on each defect, and images of the lateral surface of the acetabulum were analyzed by digital image correlation to measure peak surface strains. …

Open Capsulorrhaphy With Capsular Shift And Open Coracohumeral Ligament Reconstruction For Chronic Recurrent Multidirectional Shoulder Instability, Anna E Sumpter, Christopher S Frey, Matthew T Provencher, Lance E Leclere

Faculty, Staff and Student Publications

Background: This case features the surgical reconstruction of the coracohumeral ligament (CHL) in conjunction with open capsulorrhaphy and capsular shift for the management of chronic, recurrent, multidirectional shoulder instability (MDI). While there is a paucity of existing literature examining the clinical outcomes of this technique, biomechanical studies have implied its potential to restore stability. This procedure may be of particular benefit to patients who have failed previous conservative management and/or attempts at surgical stabilization, as well as those with severe joint hyperlaxity or connective tissue disorders.

Indications: This patient failed extensive physical therapy, as well as previous arthroscopic labral repair …

Healthcare Utilization Following Implementation Of A Pediatric Social Needs Screening Program, Ashley Gibson, Kaleigh Riggs-Harpur, Midhat Jafry, Mallika Mathur, Yen-Chi Le, Sandra Mckay

Faculty, Staff and Student Publications

Objective: This study evaluated differences in healthcare utilization among a pediatric primary care population following implementation of a universal social needs screening and referral program. It was hypothesized that emergency, sick, and hospitalization visits would decrease post-implementation, with stable or increased preventive care.

Methods: A retrospective, observational study was conducted using electronic health record data from 2 cohorts at different time periods at a large academic pediatric primary care clinic. The pre-implementation group included patients with a well-child visit from 08/2021 to 07/2022; the post-implementation group included patients from 09/2022 to 08/2023. Healthcare utilization measures of emergency department visits, hospitalizations, …

Building A Better Clinical Competency Committee: A Multi-Institutional Approach To Improving The Quality Of Resident Feedback Through Appreciative Inquiry, Nikita Khetan, Emma Omoruyi, Elizabeth Hanson

Faculty, Staff and Student Publications

Background: The Accreditation Council for Graduate Medical Education (ACGME) requires pediatric faculty to convene twice yearly as a Clinical Competency Committee (CCC) to review resident performance and provide feedback. Variability in review processes and limited feedback quality remain common challenges. Incorporating Appreciative Inquiry within a Deliberate Practice framework may enhance the quality of summative feedback provided to residents.

Methods: This project was conducted with pediatric residents and faculty during the 2019-20 academic year at The University of Texas Health Science Center at Health San Antonio (UTHSA) and during the 2021-22 academic year at The University of Texas Health Science Center …

Circulating Biomarkers In Subjects With Progressive Pulmonary Fibrosis: Data From The Inbuild Trial, Toby M Maher, R Gisli Jenkins, Francesco Bonella, Shervin Assassi, Claudia Diefenbach, Carina Ittrich, Klaus B Rohr, Martin Kolb

Faculty, Staff and Student Publications

Background: We investigated the prognostic potential of circulating biomarkers at baseline and the effects of nintedanib on changes in these biomarkers in subjects with progressive pulmonary fibrosis (PPF).

Methods: In the INBUILD trial, subjects with PPF received nintedanib (n=332) or placebo (n=331). Associations between biomarker levels at baseline and the rate of forced vital capacity (FVC) decline (mL·year-1) over 52 weeks, time to interstitial lung disease (ILD) progression (absolute decline in FVC % predicted ≥10%) or death over 52 weeks, time to first acute exacerbation or death over the whole trial, and time to death over the whole trial were …

Isolated Immune-Mediated Enteritis In Patients Treated With Immune Checkpoint Inhibitor Therapy, Sharada Wali, Rohan Srinivas Patel, Maria Julia Moura Nascimento Santos, Anirudha Chatterjee, Sophia Chenyu Fan, Sean Ngo, Tanvi Gupta, Kian Abdul Baki, Lucie Heinzerling, Bryan J Schneider, Kathryn Bollin, Jessica Philpott, Anusha Thomas, Yinghong Wang

Faculty, Staff and Student Publications

Background: Immune checkpoint inhibitors (ICIs) commonly cause colitis, but isolated immune-mediated enteritis (IMEN) is poorly characterized. This study describes the clinical features, diagnostic findings, and outcomes of IMEN.

Method: We retrospectively identified adults with cancer who developed IMEN within one year of ICI initiation, confirmed as duodenitis, ileitis, or both.

Results: Among 20,991 ICI-treated patients, 30 (0.143%) developed isolated IMEN. Median age was 69.5 years; 73.3% were male, and 80% white. The most common malignancies were gastrointestinal/hepatobiliary (26.7%) and melanoma (23.3%). Presenting symptoms included nausea (66.7%), diarrhea (53.3%), and vomiting (46.7%); 62.5% of patients with diarrhea had grade ≥2 severity. …

Conduction Abnormalities After Tavi And Their Role In Patient Management: A Systematic Review, Ionuț Tudorancea, Irene Paula Popa, Mihai Ștefan Cristian Haba, Ștefan Popa, Viviana Onofrei, Dragomir Nicolae Șerban, Ionela Lăcrămioara Șerban, Irina Iuliana Costache-Enache, Radu Iliescu, Cătălin Loghin

Faculty, Staff and Student Publications

Objective: Transcatheter aortic valve implantation (TAVI) is associated with a relatively high incidence of permanent pacemaker implantation (PPM-I). We aimed to evaluate the existing literature on electrocardiographic (ECG) changes before and after TAVI, identify predictors for PPM-I, and suggest a standardized post-TAVI ECG monitoring protocol.

Methods: A systematic literature review was conducted across multiple databases, including PubMed, Web of Science, and JSTOR, to identify studies published between 2001 and 2024.

Results: From an initial pool of 24,170 records, 17 studies met the inclusion criteria. Pre-existing right bundle branch block and significant prolongation of ECG intervals were identified as strong predictors …

Erratum: Assessment Of Skin Fibrosis In A Murine Model Of Systemic Sclerosis With Multifunctional Optical Coherence Tomography (Erratum), Harshdeep Singh Chawla, Yanping Chen, Minghua Wu, Pavel Nikitin, Jessica Gutierrez, Chandra Mohan, Manmohan Singh, Salavat R Aglyamov, Shervin Assassi, Kirill V Larin

Faculty, Staff and Student Publications

This corrects the article "Assessment of skin fibrosis in a murine model of systemic sclerosis with multifunctional optical coherence tomography" in volume 30(3), 036007.

Overcoming Stigma In Women's Hiv And Syphilis Care: The Role Of Faith In Healing, Irene A Stafford, Phillip C Johnson, Robin L Beach

Faculty, Staff and Student Publications

Point-of-care (POC) testing for syphilis and HIV is an effective way to provide same-day testing, results management, counseling, and treatment. Although commonly used in antenatal or sexual health clinics, our field study aimed to offer POC testing to women attending a standard care clinic in Guatemala. Nearly all women accepted testing, highlighting the patient-centered benefits and acceptability of screening in non-stigmatizing settings. Upon disclosure of results, especially positive diagnoses, patients drew comfort and resilience from their faith, an often-underprioritized resource not typically considered when addressing sexual health. These results underscore the value of integrating POC testing into routine care and …

Risk Factors And Outcomes Of Reintubation Following Combined Heart-Lung Transplantation, Ye In Christopher Kwon, Michael Keller, Alan Lai, Brian Bao, Joshua Pei, Matthew Ambrosio, Jay Patel, Motaz Al-Yafi, Zachary Fitch, Josue Chery, Patricia Nicolato, Vigneshwar Kasirajan, Zubair A Hashmi

Faculty, Staff and Student Publications

Background: Unplanned reintubation after combined heart-lung transplantation (HLT) significantly affects morbidity and mortality, yet national data are limited. We evaluated the incidence, predictors, timing, and outcomes associated with reintubation after HLT.

Methods: We retrospectively reviewed adults undergoing primary HLT in the UNOS registry from January 2004 to September 2024. Patients were stratified by reintubation status (defined as re-established mechanical ventilation (MV) after initial extubation). Propensity matching (1:1) balanced recipient and donor characteristics. Multivariable logistic regression models identified independent risk factors.

Results: Among 609 adult HLT recipients, 165 (27.1%) required postoperative reintubation. After 1:1 propensity score matching, 146 patients who were …

Rituximab For The Treatment Of Immune Checkpoint Inhibitor-Induced Glomerulonephritis, Yazen Alasadi, Juan Cintron Garcia, Naszrin Arani, Valda Page, Yimin Geng, Clark R Andersen, Amanda Tchakarov, Abhijat Kitchlu, Omar Mamlouk, Ala Abudayyeh

Faculty, Staff and Student Publications

Background: Among patients receiving immune checkpoint inhibitor (ICI) therapy, the most common renal immune-related adverse event is interstitial nephritis, which is caused by severe T-cell infiltration and is typically responsive to steroids; although rarer, autoimmune induction in the kidney has also been reported. There is a paucity of data regarding ICI-induced autoimmune disease in the kidney and the challenges associated with continuing ICI therapy. Here, we present a single center case series of ICI-induced glomerulonephritis with data on treatment rechallenge.

Methods: We retrospectively reviewed 241 patients who underwent kidney biopsies at our institution between 2015 and 2024 and identified those …

Collision Tumors Involving Metastatic Carcinoma And Plasma Cell Myeloma: Report Of Two Cases, Ahmed A Ahmed, Muhammad Hassaan Khalid, Asad Ur Rehman, Nghia D Nguyen, Xinhai Robert Zhang

Faculty, Staff and Student Publications

Synchronous coexistence of plasma cell neoplasms (PCNs) and metastatic carcinoma is not a common phenomenon and poses a significant diagnostic challenge requiring meticulous histopathological and immunophenotypic analysis for accurate lineage assignment. We report two cases of collision tumors comprising PCN and metastatic lung carcinoma. Case 1 involved a 68-year-old male with metastatic non-small cell lung adenocarcinoma who developed intracranial lesions; resection revealed metastatic adenocarcinoma intermingled with clonal plasma cells. Case 2 was a 73-year-old woman with a lytic iliac crest lesion whose bone marrow and lesion biopsies showed diffuse infiltration by both carcinoma and atypical plasma cells. Comprehensive immunohistochemical profiling, …

“Do Everything” Versus Realistic Surgical Interventions: Navigating The Road To Shared Decision-Making In Trauma Surgery, Victoria E Wagner, Ashna S Karpe, Martin L Blakely, Lillian S Kao, Thaddeus J Puzio

Faculty, Staff and Student Publications

"DO EVERYTHING!!" How many times have you heard that phrase from a distressed family member? We routinely receive this desperate plea, and our knee-jerk reaction is to press on, push harder, be more aggressive. We, as acute care surgeons, have spent our lives learning a craft geared towards "doing everything" to heal patients so this response comes naturally. However, how do we respond to "do everything" when the probability of a meaningful recovery is extremely low or non-existent? These situations create moral tension for surgeons who must reconcile the desire to preserve life with the obligation to avoid harm, respect …

Barriers And Facilitators To Providing Women Postpartum Care By Health Care Providers In The First 12 Months After Childbirth: A Systematic Qualitative Meta-Aggregation Review, Maryam Rouhi, Silvana Bettiol, Sarah Prior, Narges Rouhi, Theodora Dedo Azu, Christine Stirling, Lynne Staff, Linda Jones, Antigoni Leftherioti, Patricia Nicholson

Research outputs 2022 to 2026

Introduction: Postpartum care is crucial for maternal and infant health but remains inconsistently administered. This systematic qualitative review aimed to synthesize health care providers’ perspectives by exploring the barriers and facilitators experienced by health care providers in administering optimal maternal care during the first 12 months after childbirth. Methods: A systematic qualitative meta-aggregation review was conducted using the Joanna Briggs Institute methodology. Peer-reviewed qualitative studies from January 2010 to April 2024 were retrieved from MEDLINE, CINAHL, Embase, and Web of Science. Findings were mapped onto the Behavioral Model of Health Services Use. Results: Twenty-three studies were included. Four key themes …

Tea And Coffee Intakes, Copd, Adult Asthma, And Lung Function In The Uk Biobank, Nicola P. Bondonno, Pratik Pokharel, Benjamin H. Parmenter, Alysha S. Thompson, Amy Jennings, Kevin Murray, Howraman Meteran, Jonathan Hodgson, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Introduction: Previous studies suggest non-linear associations between tea and coffee intake and respiratory health, with lower risks at low-to-moderate intakes but higher, unexplored risks at high intakes. This study aims to investigate associations between tea and coffee intake and the risk of chronic obstructive pulmonary disease (COPD) and adult-onset asthma. Methods: Among 366 869 participants of the UK Biobank, intakes of tea and coffee were derived from both a food frequency questionnaire and from repeated 24 hour diet assessments. Cross-sectional associations with measures of lung function [forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC] and …

Prevalence Of Dementia In Selected Middle East And North Africa (Mena) Countries: A Systematic Review And Meta-Analysis, Mohsen Sedighi, Mohammad Hasan Shahabi, Alireza Amanollahi, Khurshid Alam, Soudabeh Shemehsavar, Zahra Shirzadi, Serena Sabatini, Ahmad R. Khatoonabadi, Matthew Prina, Akram A. Hosseini, Claire V. Burley, Jennifer Dunne, Simin Mahinrad, Iman Dajani, Ralph N. Martins, Blossom C.M. Stephan, Ali Chaari, Hamid R. Sohrabi

Research outputs 2022 to 2026

Data on dementia epidemiology in the Middle East and North Africa (MENA) region is limited. This systematic review and meta-analysis examined dementia prevalence across MENA. Databases were searched up to October 2024. Analyses were stratified by country and sex. Pooled prevalence was estimated using a random-effects model with a 95% confidence interval (CI). Fifty-two studies on the selected countries met inclusion criteria, covering 87,219 individuals with dementia from a total population of 1,045,908. The pooled prevalence was 12.16% (95% CI: 9.61–14.96) for the region and the Israel had the highest prevalence (17.00%), followed by Iran (13.20%), Turkey (11.40%), Saudi Arabia …

Driven To Serve: Exploring Meaningful Work For Doctors Through The Lens Of Public Service Motivation, Abid Hussain, Uma Jogulu, Esme Franken, Rahatulaain Ahmad, Tim Bentley

Research outputs 2022 to 2026

This paper reports on a study of meaningful work amongst doctors in a non-Western context. This study advances the current understanding of meaningful work by establishing a connection with public service motivation theory. By examining unique contextual features where societal, public systems, institutional, and individual factors are diverse and unique, we contribute to public service motivation theory in three ways. First, public service motivation theory argues that individuals are not only driven by self-interest but also by a drive to contribute to society and to help others, and that this motivation is particularly high amongst public servants in the West. …

Shared Stories, Diverse Settings: A Podcast Analysis Of Stakeholder Experiences In Rural, Remote, And International Professional Experience, Marnie Harris, Narelle Lemon

Research outputs 2022 to 2026

This study explores the experiences and perspectives of individuals involved in rural, remote, and international professional experience, with a particular focus on the support provided to pre-service teachers. Drawing on data generated through a series of in-depth podcast interviews, the research foregrounds the relational and contextual dimensions of teacher preparation across rural, remote, and international settings. Rural and remote communities face ongoing challenges in attracting and retaining teachers; therefore, this study explored the vital role that partnerships and supportive networks play in preparing pre-service teachers to succeed in these and other unfamiliar professional experience contexts. Through thematic analysis, the research …

Creatine Monohydrate For Lean Mass, Strength, And Bone Density In Postmenopausal Women: A Systematic Review And Meta-Analysis, Siavash Naddafha, Jose Antonio, Richard B. Kreider, Jeffrey R. Stout

Research outputs 2022 to 2026

Background: Menopause is accompanied by accelerated losses in muscle mass and strength and declining bone density. Whether creatine monohydrate benefits postmenopausal women are uncertain. Methods: We systematically reviewed randomized, placebo-controlled trials examining creatine supplementation, with or without resistance training (RT), in postmenopausal women. MEDLINE, Embase, Scopus, Web of Science, SPORTDiscus, and Cochrane CENTRAL were searched from 2000 to August 2025, supplemented by trial registries and reference-list screening. Eligible studies included postmenopausal women aged ≥40–45 years, intervention durations ≥6 weeks for primary analyses, and outcomes including DXA-derived lean mass, one-repetition maximum (1RM) strength, bone mineral density, physical function, and safety. Dual …

Exploration Of Best Practice Of Market Surveillance And Type Approval Of Internal Combustion Engines Emissions For Non-Road Mobile Machinery (Examine_Nrmm), Rita Hagan, Eoin Mcgillicuddy, Aoife Donnelly

Research Outputs: 2025-Present

This study examines market surveillance methods for engines in non-road mobile machinery (NRMM) in selected European Union (EU) Member States and the UK, to inform the development of an Irish NRMM market surveillance process in accordance with Regulation (EU) 2016/1628. The research found NRMM market surveillance approaches vary across Europe, with no uniform market surveillance strategy in place. Some countries, including Ireland, are currently developing an approach, while other countries have no set process in place. In countries, with an existing strategy, the process can be proactive, reactive or a combination of both.Findings highlight opportunities for Ireland to design a …

Evaluation Of Gpt-4o And Gemini Advanced On The Korean National Dental Licensing Examination: Accuracy, Consistency, And Question Generation, Eun Sun Song, Ga Hyeon Kim, Seung-Pyo Lee

Journal of Dental Sciences

Background/purpose Large language models (LLMs), such as GPT-4o and Gemini Advanced, have performed strongly on global medical examinations. However, their capabilities in non-English, dentistry-specific licensing contexts remain unclear. Thus, this study aimed to compare the performance, consistency, and question-generation abilities of GPT-4o and Gemini Advanced in the Korean National Dental Licensing Examination (KNDLE). Materials and methods This study used 1,401 text-based KNDLE questions from 2019 to 2023 in Korean. Each model responded to the questions in three separate runs. Accuracy and consistency were compared with human answers. The models generated new questions in four subject areas and attempted to solve …

Age-Related Hearing Loss Involves Mitochondrial Dna Instability And Copy Number Depletion In The Cochlea: Insights From In Vivo And In Vitro Models, Akil Turner, Bo Ding, Xiaoxia Zhu, Tam Nguyen, Parveen Bazard, Robert D. Frisina

Chemical and Biochemical Engineering Faculty Research & Creative Works

Age-related hearing loss (ARHL) is a highly prevalent sensory neurodegenerative disorder that involves various molecular mechanisms. The present study investigated if age-related oxidative stress (OS) induces alterations in mitochondrial DNA (mtDNA) copy number and heteroplasmy, using complementary in vivo and in vitro models. Aged (30-month) CBA/CaJ mice have elevated auditory brainstem response (ABR) thresholds amplitudes vs. young (3-month) CBA/CaJ mice, a key physiological characteristic of ARHL The in vitro experiments employed the strial SV-K1 cochlear cell line treated with hydrogen peroxide (H₂O₂). Both the aged cochleae and H₂O₂-treated cells exhibited a significant …