Digital Commons Network^™

Phase 1 Trial Of Withania Somnifera Leaf Extract (Rh324) In Advanced Non-Small Cell Lung Cancer Including [18f]Fdg Pet/Ct As A Short-Term Metabolic Biomarker To Assess Efficacy: A Novel Model For Assessment Of Complimentary Therapies In Early Phase Human Clinical Trials, Jin Uk Heo, Santosh Rao, Herbert B Newton, Afshin Dowlati, Raymond F Muzic, Arash Kardan

Faculty, Staff and Students Publications

Background: Withania somnifera (WS), commonly known as ashwagandha, has been used in the traditional medical system of India. It has shown significant activity against numerous solid tumor varieties in pre-clinical in vitro and in vivo studies. This study focuses on RH324 (ReHeva Biosciences, Columbus, OH), a pharmaceutical-grade formulation derived from WS, which has received FDA allowance for clinical development as a botanical drug in the treatment of cancer.

Methods: A phase 1 open label dose ranging study of oral RH324 in advanced non-small cell lung cancer (NSCLC) was conducted. The primary endpoint of the study was assessment of short-term safety …

Genome-Wide Association Study Identifies And Validates Genetic Variation In The Rig-I/Mavs Signaling Pathway Associated With Hiv-Related Kaposi Sarcoma In Children And Adults, Casey L Mcatee, Erin Peckham-Gregory, Pagna Sok, Melissa Richard, Luis Olivares, Deborah Marquez-Do, Grace Kisitu, Jeffrey Martin, Nader Kim El-Mallawany, Carl E Allen, Joseph Lubega, Michael E Scheurer

Faculty, Staff and Students Publications

Introduction: Immune deficiency and infection with human herpesvirus-8 (HHV-8) are established component causes of Kaposi sarcoma (KS), but they are insufficient to cause disease in most people at risk. Therefore, we hypothesized that genetic variation may contribute to KS risk in children and adults, as well as contribute to its unique epidemiology in sub-Saharan Africa.

Methods: To test this hypothesis, we conducted a two-phase genome-wide association study (GWAS): a discovery study in perinatally HIV-infected children (45 KS cases, 91 controls), followed by validation of significant results in a sample of adults living with HIV (215 cases, 262 controls). After standard …

Case Report: Primed Dendritic Cell Immunotherapy For Multiple Solid Tumors, Jeffrey Jones, Aly Alrabaa, William Decker, Luis Ferbeyre, Gregorio Viramontes, Rafael Gonzalez, Elideth Angulo, Antonio Zamudio, Raul Hernandez, Stephen Noga, Susana Hernandez-Reyes, Paul Zhang, Darryl Smith, Ara Karamanian, Luis Tamara, Dalton Greenwood, Matthew Halpert

Faculty, Staff and Students Publications

Many patients with advanced solid tumors ultimately develop resistance to conventional therapies, with especially limited options for those experiencing rapid progression or poor performance status, highlighting the need for personalized immunotherapies capable of inducing durable responses. In this retrospective case series, we describe the clinical course and outcomes of five adults (4 male, 1 female; median age 51 years [range, 39-62]) with metastatic solid tumors who achieved complete and durable remission following doubly loaded autologous dendritic cell therapy after failure of standard treatments, such as immune checkpoint inhibition, radiation, surgery, or endocrine therapy. Five patients, including prostate adenocarcinoma (n=1), malignant …

Point-Of-Care Ultrasound Foundations In Physics And Image Acquisition: An Innovative Hands-On Active Learning Workshop, Cherie Tator, Saul Flores, Alan Riley, Kiyetta Alade

Faculty, Staff and Students Publications

Introduction: We developed an innovative, active learning workshop to introduce foundations of point-of-care ultrasound (POCUS) physics and instrumentation. The workshop design aimed to reduce cognitive load and encourage learner-centered engagement through hands-on exploration that reinforces key principles and connects theory to practice.

Methods: First-year medical students participated in small-group, student-driven exercises to explore POCUS machine controls, transducers, and image acquisition skills. Each group was supported by a faculty member to guide activities and ensure accuracy. Students scanned pickles, hard-boiled eggs, and olives with pits; these items were selected for their low cost, sonographic characteristics, and recognizability. Later in the semester, …

Pd-L1-Centric Whole Blood-Based Immune Signature Profiles Of Tuberculosis Patients During Therapy, Johanna Eggeling, Martina Sester, Christoph Lange, Jan Heyckendorf, Barbara Kalsdorf, Anna M Mandalakas, Andrew R Dinardo, David Lewinsohn, Dagmar Schaub, Tina Schmidt, Eva Tolosa, Maja Reimann, Patricia M Sánchez Carballo

Faculty, Staff and Students Publications

This prospective study investigated whole blood-based immune cell biomarkers for pulmonary tuberculosis (TB) immunoprofiling. Blood samples from 34 healthy controls and 51 tuberculosis patients were analyzed at three timepoints: Prior to therapy (T0), after 14 days of therapy (T1), and at the end of treatment (Te). Using multiparameter flow cytometry, 386 immune cell populations were analyzed. Predictive models were developed using two machine learning algorithms. A TB5LF change score, which was based on five cell populations, effectively distinguished tuberculosis patients from controls (AUC = 0.89) and tuberculosis patients before and at the end of treatment (AUC = 0.92). Similarly, the …

Predictors Of Inpatient Rn Turnover In Rural And Urban Vha Hospitals, Katherine G Bay, Chase S Eck, Melissa K Knox, Paras Mehta, Laura A Petersen

Faculty, Staff and Students Publications

Background: The rising demand for health care delivery and an aging workforce is of particular concern in rural areas, where health care access depends upon an adequate nursing workforce. To address this shortage and optimize care, it is essential to measure when registered nurses (RN) leave inpatient direct care positions (ie, inpatient RN turnover) and identify modifiable factors correlated with RN turnover.

Objectives: Apply a novel method for characterizing inpatient RN turnover to understand factors associated with variation in RNs leaving inpatient positions at rural and urban Veterans Health Administration (VHA) hospitals.

Project design: Retrospective cohort study.

Subjects: Direct care …

"Just Let Your Soul Glo": Humorous Music In Black American Comedy Films, Drew Brady

Music Theses and Dissertations

In this thesis, I inspect ways in which music has been used to create humor and meaning in black American cinema. In doing so, I address gaps in film music scholarship, as music in comedy films and in black cinema are both neglected topics. I suggest that humor in these films arises out of a particular blend of musical irony, parody, and satire, the exact combination of which is contingent on various historical, cultural, and political factors. In order to track this trend, I analyze humorous music in eight films, each representing a unique manifestation of this tradition: Watermelon Man …

Applied Machine Learning In Mineral Prospectivity Mapping In The South Pass-Granite Mountains Of Wyoming, Carl D. York

Graduate Theses/Dissertations

The South Pass-Granite Mountains, comprised of Archean to Tertiary rocks embedded with an Archean greenstone belt in Central Wyoming, have historically been mined for gold, iron, steel, and silver. Rare earth elements have been of increasing interest in the region and thus, several datasets have become available. Knowledge driven and data driven models are used in mineral prospectivity mapping with input data including geological mapping, geochemical data, geophysical (USGS Critical Mineral magnetic and gravity data), radiometric (U, Th, K) data and multispectral remote sensing data. Mineral prospectivity has seen a rapid improvement in recent years using advancements in machine learning …

Genomic Signatures Of Decline And Recovery In An Endangered Bat, Myotis Grisescens, Marxe Altman-Orbach

Graduate Theses/Dissertations

Tremendous population declines may result in the loss of genetic diversity, which can, in turn, lead to reduced adaptive potential, overexpression of deleterious phenotypes, and further population declines. In this way, genetic drift from a severe demographic decline may ultimately lead to an extinction vortex. However, populations that avoid the loss of genetic diversity may remain viable, despite demographic crashes. Therefore, understanding genetic diversity is vital for assessing the conservation status of species that have undergone declines, and can even reflect the effectiveness of management actions. I investigated signatures of genetic bottlenecks in the gray bat (Myotis grisescens), …

Gene Editing And The Accessibility Of Bioterrorism: Rethinking Global Biosecurity In The Post-Covid-19 Era, Nicholas Morales

Graduate Theses/Dissertations

COVID‑19 demonstrated how a single biological event can strain health systems, disrupt supply chains, undermine national security, and erode public trust. This shock occurred as biotechnology became dramatically more accessible: gene editing and synthetic biology tools once limited to specialized laboratories are now widely available through inexpensive equipment, open‑source data, and decentralized expertise.

This expanded access accelerates innovation but also broadens the threat landscape. The ability to reconstruct pathogens using publicly available sequences and mail‑order DNA shows that complex biological synthesis is no longer confined to state programs. These risks are amplified by opaque biotechnology activities in China, Russia, and …

Using 1:1 Behavior-Analytic Instruction To Enhance Outcomes Of A Social-Emotional Learning Curriculum: A Retrospective Single-Case Clinical Evaluation, Cierra Vandermeer

Graduate Theses/Dissertations

Social-Emotional Learning (SEL) is the process through which people acquire and apply skills to manage emotions, form relationships, make responsible decisions, and pursue personal and shared goals, and these competencies shape identity development and daily functioning (Collaborative for Academic, Social, and Emotional Learning [CASEL], 2020). While there are many SEL programs and curricula that exist for school-aged children, there are few curricula that a) have a focus on 1:1 instruction for preschool to primary-aged children, and b) integrate and incorporate Applied Behavior Analysis (ABA) principles. This thesis reviewed a retrospective case study of a six-year-old female-identifying student who participated in …

Eastern Fox Squirrel (Sciurus Niger) Occupancy In A Southern Missouri Woodland, Daniel Garten

Graduate Theses/Dissertations

Species occupancy, which relates the probability of presence of a species at a specific place and time, is an important component of conservation and wildlife management. Principally it is used for estimation of a species’ distribution as well as understanding species interactions and quantifying environmental effects. The purpose of this study was to analyze occupancy of the Eastern Fox Squirrel (Sciurus niger) across multiple seasons (2019–2022) at Bull Shoals Field Station (BSFS), and to identify potential covariates associated with detection and colonization. Data were drawn from camera trap surveys from 26 sites during summer and fall seasons. Multi-season occupancy models …

When Speech Speaks Louder Than Truth: Language Variation And Credibility In The Courtroom, Melanie E. Spinnie

Graduate Theses/Dissertations

This study aims to investigate how linguistic variation affects perceptions of credibility in courtroom settings. It focuses on how jurors, judges, and other individuals in the legal system may exhibit bias (consciously or unconsciously) based on how a defendant or witness speaks-- this could include speech disorders as well as differences in dialect, accent, and speech style. Through review of relevant literature, review of a relevant historical case, conducting a survey, and conducting a semi-structured interview, this study explores whether certain speech patterns or characteristics are disproportionately associated with negative judgments during legal proceedings, such as reduced credibility and trustworthiness. …

Experimental Diegetic Thresholds: A Study Of Adapted Carceral Narratives [The] Nickel Boys And Sing Sing, Leslie D. Muench

Graduate Theses/Dissertations

The diegesis is the storyworld of a film, including all the characters, settings, events, and other elements. At certain times, though, that threshold is permeable, particularly when the fictional source material involves lived experiences. Two carceral films model an experimentation with adapted material and the palimpsestuous layering effect that is a result of real-life narratives being transposed into fictional ones. Nickel Boys, directed by RaMell Ross (2024), and Sing Sing, directed by Greg Kwedar (2023), endeavor to humanize a stereotypically ostracized community: Black boys and men who are incarcerated. Through the screenwriting, casting, producing, filming, and sharing of their films …

Confucian Thought As A Strategic Veil: How Western Strategy Should Correctly Compete With China, Owen Miller

Graduate Theses/Dissertations

The rise of the People's Republic of China as a peer competitor to the United States constitutes the defining geopolitical challenge of the twenty-first century, but even so, Western strategic analysis has consistently failed to engage China on its own terms. The recurrent pattern of Western misinterpretation results from projecting Western assumptions onto a state whose institutional and cultural drivers operate under fundamentally different premises, where key elements of Chinese strategic culture and the Chinese Communist Party’s (CCP) instrumentalization of Confucianism as a moral veil are instruments of domestic legitimacy and external strategic narrative. The United States must recognize that …

The Ones Who Watched: Technology, Proxy Warfare, And The Testing Ground Hypothesis, Sean J. Oliver

Graduate Theses/Dissertations

Great powers need laboratories for war. This thesis argues that great powers find these laboratories in proxy forces. Proxy warfare is not just a tool for strategic influence. It is a machine for experimentation. This study posits a central testing-ground hypothesis. It contends that great powers deliberately use surrogates to vet emerging technologies, doctrines, and mobilization schemes under the pressure of real combat. The analytical methodology is historical. It traces patterns from the ancient world's proxy forces and the innovations of the Crusades to the Cold War and the digital age. The thesis examines enduring patterns, including the tension between …

31p Solution Nmr Investigation Of Abasic Dna, Clarissa R. Krimmel

Graduate Theses/Dissertations

Base excision repair (BER) mechanisms fix single base lesions in DNA, such as T:G mismatches. During the base excision repair mechanism, an abasic site (AP site) is formed as an intermediate. AP sites are unstable and highly mutagenic; they can stop DNA replication. This research investigates how the conformational properties of abasic sites in DNA affect the binding recognition of enzymes involved in DNA repair mechanisms, including BER. Three different abasic sequences are being analyzed for this research project. A second project looks at the effects of a naturally occurring purine derivative, hypoxanthine, on the DNA backbone. These hypoxanthine lesions …

Corpus Meum, Mea Electio, Kara L. Coonrod

Graduate Theses/Dissertations

The right to bodily autonomy and reproductive freedom is something I hold very close to my heart. Women who did not wish to embrace motherhood, or who grew beyond the walls of the hearth and home, have been far more often persecuted than praised. Over the past two years, I have created artwork borrowing the visual and material language of the Catholic church (along with personally relevant folklore) to elevate my freedom of choice and bodily autonomy in the face of religiously driven political oppression. Using a less frequently referenced organ from my reproductive system to represent my struggle against …

Remediation Impacts Metal Concentrations And Metal Tolerant Bacteria In Soils Of The Missouri Tri-State Mining District, Ophelia R. Pettington

Graduate Theses/Dissertations

After over 100 years of Zn and Pb mining in the Tri-State mining district (TSMD), former mines continue to be sources of metals. Metal contaminated soils can be remediated using plant-microbe interactions. Plants manipulate their microbiome and recruit microbes to increase metal tolerance. Remediating bacteria are site-specific and identifying native microbes can accelerate remediation efforts. Studies relating microbes and metal concentrations in remediated areas in the TSMD are scarce. I collected root and bulk zone soils associated with Andropogon virginicus from remediated and non-remediated sites in Webb City, MO. I used 16S rRNA gene amplicon sequencing to evaluate the bacterial …

Heterogeneous Robots Cooperation Via Multi-Agent Reinforcement Learning, Rehab Uddin Shawon

Graduate Theses/Dissertations

Enabling heterogeneous robots with diverse capabilities, roles, and task responsibilities to coordinate effectively in complex, dynamic environments remains a fundamental challenge in autonomous multi-robot systems. Multi-Agent Reinforcement Learning (MARL) provides a promising framework for decentralized cooperation. However, most existing MARL approaches assume homogeneous agents or fixed single-task settings and suffer significant performance degradation as the number of robot and task types increases. This thesis presents a scalable shared-policy MARL framework that allows heterogeneous robots to learn specialized behaviors for individual, sequential, and collaborative tasks involving temporal and spatial dependencies through a single neural policy. I first embed robot identity directly …

The Effect Of Sex On A-To-I Editing In Skeletal Muscle During Inflammation, Skyler Lee

Graduate Theses/Dissertations

Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional mechanism mediated by ADAR enzymes that can alter RNA sequence, protein function, and gene regulation. Because ADAR1 is upregulated during inflammation and plays a critical role in innate immunity, previous studies investigated the effects of acute inflammation on RNA editing in male and female mice. Lipopolysaccharide (LPS) was used to induce inflammation, and RNA editing levels were examined in the heart, brain, and skeletal muscle. While editing levels in the heart and brain remained unchanged, skeletal muscle exhibited tissue- and sex-specific differences in editing. In this thesis, LPS treatment affected selective editing, increasing …

Climate Change In Gilgit-Baltistan: Satellite-Based Land Use/Land Cover Change Detection, Socio-Economic Dimensions, And Adaptation Strategies, Ali Muhammad

Graduate Theses/Dissertations

Climate change is increasingly transforming the cryosphere, hydrology, and human landscape of Gilgit-Baltistan, a highly climate-sensitive mountain region in northern Pakistan. This thesis investigates these transformations through satellite-based land use/land cover (LULC) change detection in four representative tehsils of Gilgit-Baltistan—Ali Abad, Gilgit, Nagar, and Sikander Abad—selected to span a gradient of human pressure and cryospheric exposure within the region. Using summer, cloud-free (< 10%) imagery from USGS Landsat 7 (2000) and Landsat 8 (2025), it conducts a multi-temporal comparison of environmental and socio-spatial change. After atmospheric correction and band compositing, the imagery is classified in ArcGIS Pro into six classes—Water, Barren land, Vegetation, Snow, Glacier, and Built-up—using a Support Vector Machine (SVM) classifier, with Maximum Likelihood Classification and Random Forest also tested but found less suitable for the final workflow. The analysis detects a pronounced reduction in mapped glacier-class area alongside a comparatively stable snow class, together with built-up expansion, while examining how temperature, precipitation, tourism, and population dynamics relate to observed LULC transitions. The results reveal a pattern of cryospheric decline and urban growth, with implications for water availability, ecological stability, hazard exposure, and settlement pressure. By integrating geospatial change detection with climatic and socio-economic interpretation, the thesis moves beyond mapping to explain interacting environmental and human drivers of landscape transformation and provides a reproducible remote-sensing baseline for monitoring land-surface change in heterogeneous mountainous terrain. It recommends integrated water-resource management, climate-resilient land-use planning, watershed and glacier monitoring, and sustainable tourism governance, supporting evidence-based decision-making by the Government of Gilgit-Baltistan and organizations working on climate adaptation, disaster risk reduction, and sustainable regional development.

Advancing Hate Speech Detection: Binary And Multiclass Approaches From Traditional Methods To Parameter-Efficient And Ontology-Guided Language Models, Mahmoud Abusaqer

Graduate Theses/Dissertations

The widespread proliferation of hate speech on social media platforms poses significant challenges for content moderation and user safety, requiring automated systems that are simultaneously accurate, efficient, and capable of fine-grained distinctions. This thesis investigates hate speech detection through five published manuscripts organized into two complementary threads: binary detection (hateful vs. non-hateful) and multiclass detection across demographic targeting categories. The binary thread progresses from a broad 38-model baseline spanning traditional machine learning, deep learning, and transformer architectures (where RoBERTa reaches 91.48% accuracy and CatBoost remains competitive at 88.60%) to parameter-efficient adaptation, in which Low-Rank Adaptation (LoRA) of large language models …

Development And Validation Of The Ipip-Ocean: A Hierarchical Facet-Level Measure Of The Big Five, Caleb Niccum

Graduate Theses/Dissertations

This study focused on developing a mid-range, hierarchical, five-factor, 20-facet personality inventory (the IPIP-OCEAN) composed of 100 items drawn from both the IPIP-NEO-300 and the Abridged Big Five Circumplex. Hierarchical confirmatory factor analysis was used to validate the factor structure. Depression and anxiety, measured with the PHQ-9 and GAD-7, were used to further validate the measure through discriminant and convergent validity by examining whether the domains and facets of the IPIP-OCEAN produced findings consistent with those reported for similar scales in prior depression and anxiety research. Numerous factor analyses were conducted on the IPIP-OCEAN dataset (N = 1,058), and a …

Synthesis And Characterization Of The New G3 Family Of Organoantimony(V) Cyanoximates, Thao Trang Phan

Graduate Theses/Dissertations

Bacterial infections pose a serious threat to humans by developing resistance, rendering antibiotics ineffective. Of the 12 antibiotics recently approved since 2017, 10 belong to an already existing class. Various resistance mechanisms, such as reduced drug uptake, active efflux, drug inactivation, and target modification, can significantly reduce the efficacy of entire classes of antibiotics. Discovering novel strategies to overcome diverse mechanisms of resistance and improve therapeutic efficacy is in high demand. Inorganic compounds with organic ligands (both complexes and organometallics) represent a new class of compounds against which antimicrobial resistance has not yet been established. Recently, we discovered two series …

In The Beginning There Was Positive Law: Section 25, Calder V. Bull, And Constitutional Continuity, Kevin C. Walsh

Scholarly Articles

From the beginning of its operation as fundamental law for the government of the United States, the Constitution has continually operated as supreme and judicially enforceable positive law. This is the principal claim I offer as an “original-law originalist” in response to contrary claims advanced by Professor Jonathan Gienapp in Against Constitutional Originalism: A Historical Critique. Gienapp argues in Against Constitutional Originalism that “[h]istoricizing the original Constitution . . . poses a foundational challenge to originalism as it has long been conceived.”2 Constitutional originalism depends on perceived continuity with the past. But the perception of constitutional continuity turns out to …

The Pedagogy Of Legal Synthesis, Stephen Mortellaro

Scholarly Articles

The ability to synthesize implicit legal principles from many ambiguous cases is a mark of a skilled attorney. But legal synthesis is notoriously challenging to teach, and law students typically receive little explicit guidance on how to synthesize. The literature likewise offers law professors little direction on how to impart the skill successfully. This Article serves as a guide for professors to effectively train law students to synthesize implicit legal principles. Drawing upon cognitive science, the study of logic, and educational research, this Article explains the challenges of learning legal synthesis and equips professors with pedagogical methods and curricular resources …

Bracing The Wobbly “Three-Legged Stool” By Increasing Homeownership Opportunities For Low- And Middle-Income Workers, Regina T. Jefferson

Scholarly Articles

Traditionally, the primary sources of retirement income were personal savings, the private retirement system, and Social Security. These three sources have been described metaphorically as the “three-legged stool” of retirement security. In this framework, each leg was viewed as a separate and distinct source of income that provided support throughout a worker’s retirement. Each source presented different and varying degrees of risks that were pooled collectively among the individual, the employer, and the government. Each source also functioned independently of the other two. Thus, the traditional framework of retirement income was thought to be ideal because it balanced and diversified …

Constitutional Theory At A Catholic University, J. Joel Alicea

Scholarly Articles

No abstract provided.

The Constitution Of Conversations: The Enduring Legacy Of Sandra Day O'Connor, Derek A. Webb

Scholarly Articles

Soon after Justice O'Connor's passing in December 2023, commentators and court watchers across the ideological spectrum questioned whether anything in the legacy of the first woman to serve on the Supreme Court— once called “the most powerful woman in Washington, D.C.”—remained intact.

Drawing upon speeches and interviews she gave over her entire forty-year public career, I argue that O’Connor’s deepest and most enduring contribution was a subtle, compelling, interconnected, and yet today largely countercultural vision of the Constitution as a site of multiple conversations, a “Constitution of Conversations,” that took place variously within institutions, across institutions, and across time. More …