Digital Commons Network^™

The Effects Of Vitamin K On Neuronal Ferroptosis, Chelsey P. Eighmey

Electronic Theses & Dissertations (2024 - present)

Dementia is a crippling illness affecting millions worldwide causing significant public health burdens with long-term care. The lack of treatment options results in many years of suffering for affected individuals and their loved ones who often become primary caretakers. Decades of study have focused on treating dementia with little-to-no success, so an emphasis is needed on attempting to prevent disease progression altogether. This research explored vitamin K as a potential strategy for prevention of dementia onset or progression through the mechanism of suppressing ferroptosis. Ferroptosis is a type of cell death suggested to contribute to the hallmark traits of Alzheimer’s …

The Relationship Between Interoceptive Awareness And Eating Disorder Symptomatology, Madelyn G. Johnson

Electronic Theses & Dissertations (2024 - present)

Interoceptive awareness (IA; e.g., the ability to perceive and interpret internal bodily sensations) is increasingly recognized as central to eating disorder (ED) psychopathology, yet findings remain mixed regarding whether heightened IA is protective or maladaptive. Across two studies using a sample of 654 college students (Mage = 18.74, SD = 1.56; 46% White; 58% female) from a large northeastern U.S. university, we examined (1) how specific IA facets relate to ED symptom severity, and (2) whether anxiety sensitivity (AS) helps explain these associations. In Study 1, linear regressions predicting Eating Disorder Examination Questionnaire–7 (EDE-Q7) scores showed that nearly all MAIA-2 …

Population Genomics And Evolution Of Pseudomonas Aeruginosa, Samara T. Choudhury

Electronic Theses & Dissertations (2024 - present)

Pseudomonas aeruginosa is a Gram-negative bacterium ubiquitous in diverse environments and an opportunistic pathogen in humans. It is a leading cause of chronic lung infections in cystic fibrosis patients and of hospital-acquired pneumonia and sepsis. With a large flexible genome and abundant mobile genetic elements, P. aeruginosa exhibits high levels of antimicrobial resistance (AMR), making it a significant public health threat. Evolutionary processes such as homologous recombination, and horizontal gene transfer generate extensive genomic diversity in this species and facilitate the spread of resistance genes. In this dissertation, I investigate the genetic and evolutionary factors shaping P. aeruginosa population structure …

Advancing Periodic Time Series Analysis: Application, Bias Assessment, And Optimal Window Selection In The Variable Bandpass Periodic Block Bootstrap Method, Yanan Sun

Electronic Theses & Dissertations (2024 - present)

Time series analysis is essential for understanding long-term patterns, periodic behavior, and underlying correlations in complex datasets. The periodically correlated (PC) time series is a type of time series where the correlation structure repeats over fixed intervals. The Variable Bandpass Periodic Block Bootstrap (VBPBB) has recently been proposed as a resampling method that preserves PC structures through the use of periodogram, bandpass filters, and block bootstrap resampling. Although promising, VBPBB remains underutilized, and its limitations have not been fully examined. This dissertation advances both the application and methodological development of the VBPBB.

The first project applies the VBPBB to a …

Improving Clinical Decision-Making: Reducing The Affect Heuristic In Substance Use Treatment, Corey M. Monley

Electronic Theses & Dissertations (2024 - present)

Therapists are at risk for engaging in the affect heuristic, which occurs when automatic emotional reactions influence clinical decision-making more than objective data about clients. Emotional reactions are common when treating clients using substances (CUS), but the influence of the affect heuristic on therapists’ clinical decision-making with CUS has yet to be quantified. This study investigated (1) the extent to which therapist trainees engage in the affect heuristic with CUS and (2) whether it can be reduced through brief cognitive science training. Graduate-level therapists (n = 130) were randomized to one of two conditions: brief online training involving …

School-Based Interventions With Youth Engaging In Bullying Behaviors: Effective Strategies From The Perspective Of School Social Workers, Elizabeth A. Crowe

Electronic Theses & Dissertations (2024 - present)

Bullying is a nationally recognized social problem associated with harmful consequences for all youth involved. Despite their crucial role in bullying interventions and student success, the practices and perspectives of school social workers are notably absent from academic literature. This survey research study sought to identify strategies that school social workers use with youth engaging in bullying behavior; distinguish which strategies are the most and least effective from the perspective of school social workers; and recognize the supports and barriers school social workers face when implementing bullying interventions.

Survey data from a sample of school social workers answered these questions. …

Applications Of Machine Learning For Evaluating Downward-Coupled Stratosphere-Troposphere Interactions And Subseasonal Forecasts Of Opportunity, Elena M. Fernandez

Electronic Theses & Dissertations (2024 - present)

Wintertime stratospheric dynamics provide key information for understanding atmospheric teleconnections and improving subseasonal-to-seasonal (S2S) predictions on timescales of two weeks to two months. Periods of enhanced predictability, often referred to as forecasts of opportunity, arise from large-scale teleconnected variability, within which the stratosphere serves as an important precursor for tropospheric states, such as near-surface temperatures. While traditional diagnostics of downward coupled stratosphere-troposphere interactions typically rely on zonal-mean representations of wind and geopotential height, this dissertation presents an alternative vortex-centric framework through metrics that capture the daily geometric and dynamical evolution of the stratospheric polar vortex. The proposed stratospheric …

Paying The Price: How Financial And Health Stress Can Impact Incidental Memory In The Survival Processing Paradigm, Bailey C. Hall

Electronic Theses & Dissertations (2024 - present)

Cognitive psychologists have examined how evolutionary pressures can shape memory systems and how survival-relevant information is processed. Nairne et al. (2007) established the survival processing paradigm and showed that processing information within a survival context reliably enhances later recall. Previous research has identified academic pressure and financial stress as the most influential stressors for undergraduate students (Patel & Lewis, 2023). Financial stress is widespread and influences multiple domains of life, including health behaviors and psychological well-being (Northern et al., 2010). In this study, two scenarios were created to explore financial and health stress compared to the original grassland survival scenario. …

Time Series Decomposition And Forecasting Of Alzheimer’S Disease Mortality Using A Kolmogorov-Zurbenko Filter, Jack D. Farrell

Electronic Theses & Dissertations (2024 - present)

Alzheimer’s disease mortality has substantially risen in recent history, placing a significant burden on public health infrastructure and highlighting the need for improved analytical methods to better understand mortality data patterns and offer reliable predictions. Time series methods often struggle to balance both accuracy and interpretability, which hinders the ability to gather meaningful insights from time series data. To address these limitations, this study applies the Kolmogorov-Zurbenko (KZ) filter to monthly U.S. Alzheimer’s mortality data spanning from 1999 to 2023 and decomposes the series into long-term trend, seasonal, and noise components on a logarithmic scale. Long-term trend accounts for 86.49% …

Punishment, Fast And Slow: Five Experiments On Behavioral Economics In The Mass Incarceration Context, Nathaniel M. Schutten

Electronic Theses & Dissertations (2024 - present)

As many jurisdictions across the United States seek to reduce their prison populations, a pressing question is whether the public will support the reforms necessary to do so. Public openness to reform likely varies across policy areas, with the path of least public resistance occurring where attitudes are the most malleable and loosely held. A major challenge, however, is that traditional methods for measuring public opinion are poorly suited to identifying which policy areas are characterized by such weakly held views.

This dissertation develops a novel behavioral economics framework for identifying these areas. I theorize that when public opinion is …

Neural Network Transceiver For Ltv Mimo Channels, Iresha Amarasekara

Electronic Theses & Dissertations (2024 - present)

Eigenfunctions are commonly employed to characterize kernels in various data-driven analyses. In machine learning, eigenfunction decomposition typically relies on Mercer's theorem, which assumes kernel symmetry. However, this condition is often unmet in communication systems, where channel kernels are asymmetric due to differences in downlink and uplink propagation environments. The High-Order Generalized Mercer's Theorem (HOGMT) provides a systematic approach for decomposing multidimensional asymmetric kernels into eigenfunctions. To address the complexity of eigen-decomposition, this work introduces a baseline neural network (NN) framework HNET. The HNET framework is further enhanced by incorporating the augmented Lagrangian method (ALM) to explicitly enforce orthogonality constraints. This …

Stem Cell-Derived Developmental Models For Translational Evaluation Of Disease And Therapy, Maria B. Paredes-Espinosa

Electronic Theses & Dissertations (2024 - present)

Human development as well as congenital and adult diseases emerge from coordinated interactions among multiple cell types, regulatory programs, and tissue compartments that remain largely unresolved. Conventional simple lineage-restricted in vitro systems poorly capture this complexity. My dissertation uses human stem cell-derived developmental models to study human cardiac morphogenesis and heart diseases and application of a networked neuron platform to explore senescence-associated neurodegeneration impact on Alzheimer’s neurons.

Elongating multi-lineage organized cardiac (EMLOC) gastruloids are a synthetic embryology model that co-generates contractile cardiomyocyte populations alongside mesenchymal, endothelial, epicardial-like, neural crest-associated, and neuronal cells within a shared in vitro developmental environment. Single-cell …

New Game Start: Playing With Power, Community And Change In Video Gaming Culture, Jonathan D. Muller

Electronic Theses & Dissertations (2024 - present)

Video gaming culture has long been a site associated with norms and values of whiteness, masculinity, and neoliberalism, with games, players, and developers all reinforcing these. Recently though, gaming culture has been directly involved with social movements and forms of resistance that are contrary to these norms and values. The typical gamer is no longer a white man, and gaming culture is now acknowledged to include race and gender dynamics that are close to that of the broader population. These communal shifts have both challenged and reinforced existing power structures. This research addresses these shifts and struggles by analyzing how …

Effect Of Workload, Burnout, And Flexible Work Practices On The Well-Being Of University Faculty And Staff, Caroline O. Rogers

Electronic Theses & Dissertations (2024 - present)

The present study examined the impact of workload, burnout, and flexible work practices (FWPs) on the well-being of higher education employees from the perspective of Job Demands-Resources (JD-R) theory. A moderated mediation model was hypothesized, wherein workload would be associated with well-being through burnout, and that this association would be attenuated by the presence of FWPs. A total of 477 full-time faculty, staff, and affiliated research foundation employees from a large public university in the Northeast region and a broader range of colleges and universities across the United States of America completed a cross-sectional survey. Validated measures assessed workload (Quantitative …

Studies Towards Chemical Synthesis Of Homogeneous Prion Glycoprotein, Baotong Tian

Electronic Theses & Dissertations (2024 - present)

Prion diseases are fatal neurodegenerative disorders initiated by conformational misfolding of the prion protein (PrP), which generates pathogenic conformers that propagate via templated conversion and accumulate as aggregates. Glycosylation can modulate the PrP folding energy landscape, thereby biasing folding trajectories and the distribution of resulting conformational states. Bank vole PrP contains two N-linked glycosylation sites, and disentangling the contributions of site occupancy versus glycan structure requires homogeneous, site-defined glycoforms. In contrast, biosynthetic expression typically produces heterogeneous glycoform ensembles due to multistep Golgi processing, precluding independent control of glycan identity at each site. Here we report a chemical synthesis strategy of …

Next-Generation Computing Hardware: Advancements In Tantalum Oxide Reram For Ai And Neuromorphic Applications, Rajas Ravindra Mathkari

Electronic Theses & Dissertations (2024 - present)

The rapid development of artificial intelligence, machine learning, and data-intensive computing has exposed the fundamental limitations of conventional von Neumann architectures, in which energy and time are continuously lost transferring data between physically separate memory and processing units. In contrast, the human brain performs complex computations directly at the point of memory storage through billions of parallel synaptic connections, a paradigm known as in-memory computing. Realizing this in hardware requires memory devices that are fast, energy-efficient, non-volatile, and capable of storing multiple resistance levels in an analog manner. Resistive Random Access Memory (ReRAM) based on tantalum oxide (TaOx) is one …

The Effect Of A Functionally Indicated Choice-Based Antecedent Intervention On Academic And Behavioral Outcomes For Students In A Public School, Alyssa M. Rodriguez

Electronic Theses & Dissertations (2024 - present)

The present study examined the effects of functionally indicated choice-based antecedent interventions on academic and behavioral outcomes for elementary general education students exhibiting elevated levels of off-task behavior during independent seat work. A replicated hybrid single-case design was used to compare two interventions: choice of task sequence (across-activity choice) and choice of peer (within-activity choice). Brief functional behavioral assessments (FBAs) informed hypothesized behavioral function and intervention match. Dependent variables included academic engagement (on-task behavior), with off-task behavior conceptualized as its inverse, as well as academic completion and accuracy; social validity was assessed from teachers and students. Results indicated support for …

When Civilians Involve Themselves In Crime Control: Do Perceived Police Legitimacy And Trust In The Police Predict Support For Vigilantism And Citizen’S Arrests?, Charlotte T. Parque

Electronic Theses & Dissertations (2024 - present)

Recent cases in which civilians involved themselves in the crime control process have garnered divided reactions, with some people supporting and others disapproving the civilians’ actions. Although existing research shows that perceptions of the police predict support of civilians involved in crime control, exact directions of the effects conflict. I address these conflicting findings by examining how people conceptualize police legitimacy and trust in the police, whether those conceptualizations align with scholarly definitions of legitimacy and trust, and explore if the two constructs differentially predict support of vigilantism. Additionally, I explore whether people approve of two types of civilian crime …

An Exploratory Mixed-Method Study Of Systems For Adhd Accommodation Implementation In New York State Middle Schools, Stacie Fenn Smith

Electronic Theses & Dissertations (2024 - present)

This mixed-method study examined organizational structures for ADHD accommodation implementation in New York State middle schools. While extensive research documents the effectiveness of specific ADHD accommodations, limited scholarly attention has focused on how educators organize themselves to deliver these supports consistently across multiple classroom settings. This study addressed that gap by investigating how educational leaders, teachers, and support staff structure systems for accommodation implementation. Grounded in Ecological Systems Theory (Bronfenbrenner, 1979) and Organizational Behavior Theory (Robbins & Judge, 2017), the study examined implementation across three organizational levels: building leaders, coordinators, and classroom teachers and support staff.

Data collection included a …

Exploring The Impact Of Mindful Social Media Literacy Instruction On Self-Regulated Smartphone Use, Catherine Coons

Electronic Theses & Dissertations (2024 - present)

Smartphone and social media addiction, and increasingly high rates of anxiety and other mental health challenges, afflict contemporary undergraduate students more than previous generations of college students. The mental health challenges faced by students directly affect their academic potential, influencing their ability to concentrate, maintain confidence, get adequate sleep, and sustain overall well-being. Despite the increasing prevalence of these issues, universities often lack sufficient resources, services, and trained staff to support this growing student population adequately.

This study examines the impact of mindfulness-based social media literacy instruction on curbing problematic social media use in college students. While extensive research has …

Hidden Markov Models For Stock Market Regime Prediction, Meghan Blanch

Electronic Theses & Dissertations (2024 - present)

Hidden Markov Models (HMMs) are a powerful mathematical system used for analyzing time sequences in which the underlying states are unable to be directly observed. This project strives to develop the theory and computation of such models, including deriving the forward and backward variables, the Baum-Welch algorithm, and the Viterbi algorithm. Each of these HMM components are derived and explained to demonstrate the probabilistic principles that allow HMMs to be effective for modeling sequential data.

To demonstrate its practical relevance, the HMM is applied to financial time series. The observable stock market returns tend to be influenced by market regimes …

Development And Analysis Of An Embedded Hardware Platform For Low-Power Rram–Based In-Memory Computing And Neural Network Applications, Jeelka Solanki

Electronic Theses & Dissertations (2024 - present)

Conventional computing architectures are based on repeated data transfer between memory and the compute unit; however, artificial neural network applications rely on data-intensive vector-matrix multiplication as a mathematical operation, where data movement from memory to compute processor results in increased power consumption and reduced performance. Possible solutions to this problem include in-memory computing, which addresses the data transfer bottleneck by computing directly within the memory. To demonstrate the potential of this approach, our research group fabricated hafnium oxide-based resistive random-access memory (RRAM) arrays using a 65nm CMOS technology for in-memory compute operations. This work demonstrates the design and development of …

Academic Satisfaction Of Graduate Students In Mental Health Professions: Mediating Roles Of Burnout And Engagement, Yu Ying Li

Electronic Theses & Dissertations (2024 - present)

Academic satisfaction for students is as critical to their retention and well-being as job satisfaction for working adults; however, it has received limited empirical attention particularly among graduate students in mental health-related programs. One of the barriers to mental health trainees’ satisfaction with their academic training is burnout. The current study evaluated the applicability of Study Demands-Resources (SD-R) framework (Lesener et al., 2020) to trainees. Specifically, this study examined the relations between study demands (i.e., perceived stress), study resources (i.e., supervisory alliance and social support), student burnout, student engagement, and academic satisfaction. It also tested if student burnout and engagement …

Understanding Support And Success: A Cross-Group Analysis Of Student Support Services And Nontraditional Graduate Student Experience, Erica Shudt

Electronic Theses & Dissertations (2024 - present)

This study explored how nontraditional graduate students perceive their experiences with student support services within a Research 1, public university. The purpose of this study was to understand how these services impact their overall academic experience. Findings from semi-structured interviews with nontraditional graduate students and student support staff using a qualitative approach revealed four themes. These themes included (1) a shared emphasis on connection and belonging, (2) flexibility as a foundation for support and success, (3) individualized student-centered support, and (4) the acknowledgement of nontraditional student support identity. Both groups identify that meaningful support is within relationships with faculty and …

School Leaders’ And Teachers’ Sensemaking Of Performance-Based Learning And Assessment Reform Initiatives, Kate Jarrard

Electronic Theses & Dissertations (2024 - present)

Educational leaders occupy a difficult position in the landscape of reform, as they are at times charged with initiatives that conflict with existing guidance and core instructional work. Effective change requires more than program redesign; it demands shifts in people’s behavior. For school leaders, the challenge is not simply understanding a new initiative, but making personal sense of it and then communicating it coherently to staff in ways that generate genuine commitment, all while navigating the gap between standard and innovative practice, bridging from policy intent to classroom-level implementation.

In the case of school performance, standardized testing has long anchored …

Corannulene: Optimized Synthesis And Four-Fold Reduction, Guy Rozenman

Electronic Theses & Dissertations (2024 - present)

Corannulene is a bowl-shaped π-conjugated fragment of the ball-shaped C₆₀-fullerene that undergoes stepwise multielectron reduction and can accept four electrons to form the aromatic tetraanion, C₂₀H₁₀⁴⁻. Prior literature has established this charge state in donor-solvated alkali-metal assemblies: early solution studies identified the formation of the tetraanion under lithium reduction in THF, and later X-ray diffraction crystallography demonstrated a triple-decker lithium sandwich in which two corannulene tetraanion decks encapsulate five Li⁺ ions. The central objective of this thesis is to determine whether the corannulene tetraanion can instead be isolated as a bulk solvent-free alkali-metal salt containing only corannulene and …

Informationally-Optimal Measurements On Single-Qubit Systems, Adam V. Preston

Electronic Theses & Dissertations (2024 - present)

This thesis will focus on deriving informationally-optimal quantum state tomographic measurements on single-qubit systems, with the definition of informationally optimal to be defined as those measurements which maximize the average information gain. The informationally-optimal measurements that will be covered include projective measurements (formally building off of the work of [1] and putting it on firm, information-theoretic foundations), and more general types of quantum measurements called directional (also known as rank-one) positive operator-valued measure (POVM) measurements, and, finally, adaptive directional POVM measurements.

For projective measurements, we build on the work of Wootters and Fields ([1]) and show, via analytical methods and …

Constructing The Political “Other”: Affective Polarization And Cross-Ideological Portrayals On Instagram, Amanda M. Novellin

Electronic Theses & Dissertations (2024 - present)

Instagram has frequently been characterized by users as a platform that permits the circulation of hostile and adversarial political content due to comparatively limited moderation practices. In January 2025, Meta CEO Mark Zuckerberg announced changes to content moderation policies on Facebook and Instagram, including the removal of third-party fact-checking mechanisms. These platform-level changes further reshaped the political information environment in which online discourse occurs. However, even prior to these policy changes, Instagram had established itself as a prominent space for highly polarized political expression across the ideological spectrum.

This thesis examines how political polarization in the United States is reflected …

Moderators Of Subjective Distress And State Body Image During Open And Blind Weighing, Danielle E. Peters

Electronic Theses & Dissertations (2024 - present)

Objective: Body image disturbances are central to eating disorder (ED) pathology and are often addressed through exposure-based methods, such as open weighing. Open weighing is recommended in evidence-based ED treatments, but many clinicians and patients prefer blind weighing. It may be that pre-treatment patient characteristics may influence how distressed they feel by open and blind weighing. As such, the present study aimed to 1) compare how open and blind weighing impact subjective distress and state body image, and 2) examine whether self-weighing tendencies, body avoidance, body checking, body checking-related beliefs, intolerance of uncertainty, and ED psychopathology moderate the relationship between …

Inflammation In Early Borrelia Burgdorferi Skin Infection, Ariana Nobles

Electronic Theses & Dissertations (2024 - present)

Borrelia burgdorferi (Bb) is the causative agent of approximately 476,000 cases of Lyme disease in the United States and rising. Bb is spread through infected saliva of the black-legged tick, Ixodes scapularis, to the host. Patients infected with Bb experience short-term symptoms, such as erythema migrans (EMs), fatigue, pain, and cognitive impairment. If left untreated, Bb infection will cause long-term health complications, like Lyme neuroborreliosis and Lyme arthritis. It is postulated that symptoms associated with Lyme disease are driven in part by inflammation.

My thesis focuses on the skin as it holds significant immunological importance in the …