Digital Commons Network^™

Deciphering Chemomechanical Couplings In Proteins Using Molecular Dynamics And Enhanced Sampling Techniques, Matthew Brownd

Graduate Theses and Dissertations

Proteins function through a complex interplay between chemical interactions and mechanical motions across multiple spatial and temporal scales. Understanding how ligand binding, conformational dynamics, and structural flexibility collectively regulate protein function remains one of the central challenges in molecular biophysics. This dissertation presents a computational investigation into chemomechanical coupling in three distinct classes of biomolecular systems using all-atom molecular dynamics (MD) simulations and enhanced sampling methods, with particular emphasis on free-energy calculations and long-timescale conformational analysis. The first part of this work focuses on ligand binding in hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which regulate rhythmic electrical activity in the heart …

Writing Through The Plague: Memory, Trauma, And Survival In Arabic And English Narrative, Zainab Abbood Jawhar Aldaoseri

Graduate Theses and Dissertations

This thesis examines how Arabic and English literary and intellectual traditions responded to the Black Death as a shared yet differently articulated experience of collective trauma. Drawing on trauma theory, particularly the work of Cathy Caruth and Dominick LaCapra, it analyzes how plague narratives function as cultural mechanisms for processing mass suffering. Through a comparative study of Arabic historiographical, theological, medical, and poetic texts alongside English allegorical, mystical, autobiographical, and satirical writings, this project argues that both traditions developed distinct narrative strategies to render the trauma of plague intelligible. Arabic plague literature, represented by figures such as Ibn Khaldūn, Ibn …

Analyzing The Effects Of Message Testing On The Public's Opinion About Gene Editing In Agriculture And Medicine, Luke Sanford Wimpy

Graduate Theses and Dissertations

This paper will present results from the final survey of a multi-stage project examining factors that influence opinions about gene editing in agriculture and medicine. In this final survey, 3,200 U.S. respondents were recruited and randomized to view one of eight videos that communicated the safety of gene editing to determine which factors are most influential in changing opinions. The eight videos were designed based on data collected from focus groups and three previous surveys in this multi-stage project. The eight videos varied by three attributes: messenger, message, and application. The messenger in the videos was either a researcher or …

Grazed Pasture Effects On Greenhouse Gas Emissions In The Ozark Highlands, Tyler Buchanan

Graduate Theses and Dissertations

In the United States (US), grazinglands serve as the main foundation for the livestock industry, and, in Arkansas specifically, pastures are essential for rotational grazing and dairy operations. Climate change is increasingly becoming a concern in the agriculture industry, largely caused by anthropogenic activities increasing greenhouse gas (GHG) concentrations in the atmosphere, at least partly due to the nutrient recycling that occurs from animal manure additions in grazinglands. Therefore, quantifying GHG emissions from pastures is essential to better understanding the impacts of grazing on the environment. The objective of this study was to quantify and evaluate the potential effects of …

Dissecting The Complex Genomic Landscape Underlying Oxidative Stress Resistance Using Natural Variation In Yeast, Sonali Lakshika Anne Lenaduwe

Graduate Theses and Dissertations

Stress is experienced across the tree of life. Survival in fluctuating environments depends on a robust genetic architecture. This dissertation examines the genetic and metabolic determinants underlying one such adaptive response: cross-protection. Leveraging natural variation in the stress responses of budding yeast, Saccharomyces cerevisiae, I examine the genetic variation contributing to ethanol-induced cross-protection against oxidative stress. Acquired stress resistance, in which mild pre-exposure improves survival to subsequent stresses, is prevalent across diverse organisms and can involve both same-stress and cross-protection. Using high-throughput bulk segregant analysis (BSA-seq) and advanced intercross mapping populations derived from natural yeast isolates, I identify quantitative trait …

The Effects Of Vocational Self-Concept Crystallization And Career Choice On Crop Farming Apprenticeship Completers: An Exploratory Qualitative Analysis, Stormy Zane Speaks

Graduate Theses and Dissertations

Across the United States, a farmer shortage threatens the future of food production as the population continues to grow. However, farming apprenticeship programs may be a solution to this crisis. This study addressed a gap in research regarding the career decision-making processes of farm apprenticeship completers. Specifically, this study sought to identify whether farm apprenticeship completion resulted in greater vocational self-concept crystallization as well as farming as a career choice. Due to the lack of research, an exploratory qualitative research design was most suitable for this study. Donald Super’s self-concept development theory was the theoretical framework. Self-concept development theory was …

Assessing The Potential Of Taming Chicken Gut Commensal Bacteria Using Random Transposon Mutagenesis, Arjun Chapagain

Graduate Theses and Dissertations

The chicken gut microbiome comprises hundreds of bacterial species whose functional roles remain largely unknown, in part because the tools needed to experimentally manipulate these organisms in their native community context have not been systematically developed or validated. This dissertation addresses the gap through three connected research chapters that progressively build a framework for transposon-based genetic delivery in the chicken cecal microbiome, moving from community-wide accessibility mapping to vector optimization to library preparation refinement. In Chapter 2, we established the community-level insertion landscape in chicken cecal metagenome using Himar transposon delivery via RP4 conjugation and aligned Tn-seq reads to a …

May 2026 Library News, University Libraries

Library News

No abstract provided.

The Reliance On Children In Atomic Bomb Literature, Chenyeng Vang

English Undergraduate Honors Theses

This paper explores the conventions of children’s literature, or what children embody in literature, and how it functions within atomic bomb literature in three ways: filling the gap of the unreliability of language, pushing past binaries through its queerness, and universalizing messages of peace to focus on a broad vision of a better future. Analysis involves atomic bomb literature written within the first five decades of the bombings, from 1945 to 1995. This research additionally seeks to answer the question: why children’s stories? This paper concludes that the dependence on children within atomic bomb literature hinges upon constructions of children …

Microplastics And Generational Harm, Sara Najafi

Anthropology

Microplastics are persistent environmental contaminants increasingly detected in ecosystems and the human body, raising concerns about their effects on health and future generations. This paper examines the environmental pathways, biological mechanisms, and reproductive consequences of microplastic exposure, with particular attention to female reproductive health and fetal development. Current evidence indicates that microplastics can contribute to oxidative stress, inflammation, endocrine disruption, DNA damage, and cellular dysfunction, while also accumulating in reproductive tissues, follicular fluid, placental tissue, and breast milk. These exposures may impair ovarian function, fetal development, and long-term health outcomes. The paper also considers environmental inequalities that may increase exposure …

Monastic Design: Recovering The Sacred, Thomas Larkin Derek Crompton

Architecture Theses

Throughout history, transcendental meaning has been woven into the very fabric of architecture to awaken and attune our souls toward a greater understanding of the inherent, unquantifiable aspects of life. Design elements such as light, material, proportion, and mystery were used as communicators of meaning rather than merely tools of utility. However, with the rise of positivism in the modern period, many transcendental elements of design were disregarded in favor of a more functionalist approach. The strategies employed by this approach influenced much of modern religious architecture and have resulted in many churches that lack the fundamental principle they claim …

Birds, Bees, + Butterflies: Restoring Suburban Wildlife Homes And Habitats In Bismarck, Nd, Elena Joubert

Landscape Architecture Theses

For centuries humanity has been expanding its borders, stretching in and across a wide range of ecosystems, optimizing the land for human use and habitation. Animal-aided design is a possible solution to the loss of habitats; a new methodology of designing green spaces for the use of specific native species. Green spaces are vital to the mental and physical well-being of people, and the presence of native species such as songbirds or butterflies can further increase those benefits. Only 4.2% of North Dakota is developed land, referring to urban and industrial usage, but within these spaces are opportunities to conserve …

Race To Mitigate Aortic Dissection: Exercise, Pde5a, And The Dissecting Aorta, Siddharth K Prakash

Faculty, Staff and Student Publications

No abstract provided.

Neurointerventional Advances In 2025, Amol Mehta, Sunil A Sheth, Ashutosh P Jadhav

Faculty, Staff and Student Publications

No abstract provided.

Community Vitality: Establishing Blue Zone Based Education For Elementary Students, Eliza G. Heinrich

Honors College Theses

Blue Zones are areas of the world where people live longer and healthier lives. These areas share several key characteristics called the Power 9 (Buettner & Skemp, 2016). The goal of this study was to increase general knowledge of Blue Zones as well as the implementation of healthy habits to increase the longevity of the population of Calloway County, Kentucky through educational sessions of elementary students. Researchers involved in this study asked participants to fill out a pre-test to gauge knowledge of Blue Zones. Participants then underwent several educational sessions and activities surrounding the Power 9. Participants were then asked …

Evaluating The Rural/Urban Divide In Conservation: Methods Of Improvement In Conservation Programming Across Kentucky, Lauren Tackett

Honors College Theses

Kentucky’s lands and waterways have always defined the state. Our unique karst landscape, combined with the Appalachian Mountains and Ohio River, help characterize the state and its identity. However, across Kentucky conservation efforts within recent years have been under attack. Through legislation changes and policy challenges, various bills have sought to repeal Kentucky’s conservation efforts regarding water, soil, and land use. Furthermore, there has been a rise in environmental disasters within the state that cause long term issues for both rural and urban communities to contend with. The responsibility of land stewardship falls on a variety of entities but weighs …

Understanding The Role Of Toxs As A Bile Sensing Component Of The Toxrs Virulence Regulatory System In Vibrio Spp., Minje Kim

Dartmouth College Ph.D Dissertations

Pathogenic Vibrio bacteria, such as V. cholerae and V. parahaemolyticus, colonize in the human small intestine to cause severe gastrointestinal disease. During the infection, these bacteria encounter bile salts, antimicrobial cholesterol metabolites secreted into the intestine. Pathogenic Vibrio species have evolved to utilize bile salts as signals to regulate virulence. The signaling depends in part on ToxRS, a conserved co-component transmembrane transcription regulator. ToxRS consists of the transcription factor ToxR and its membrane-tethered binding partner ToxS. ToxS is required for ToxR stability and full transcriptional activity. Although bile salts are known to influence ToxRS-dependent virulence gene expression, the molecular …

Tak1 Is A Key Regulator Of Oncogenic Signaling And Differentiation Blockade In Rhabdomyosarcoma, Kavya Mathukumalli, Phuong T Ho, Raksha Bhat, Meiricris Tomaz Da Silva, Tagari Samanta, Meghana V Trivedi, Bin Guo, Benny A Kaipparettu, Ashok Kumar

Faculty, Staff and Students Publications

Rhabdomyosarcoma (RMS) is a malignant soft tissue sarcoma with a skeletal muscle phenotype, accounting for approximately 50% of all pediatric soft tissue sarcomas and 8% of all childhood cancers. Although RMS cells express myogenic regulatory factors, they fail to undergo terminal differentiation into mature muscle cells. Transforming growth factor β-activated kinase 1 (TAK1) is a key signaling mediator that activates multiple intracellular pathways, yet its role in RMS has remained unknown. Here, we show that TAK1 expression and activity are markedly elevated in RMS cell lines and patient tumor specimens. RNA-Seq and reverse phase protein array (RPPA) analyses revealed that …

Maternal Fish Intake In The Year Prior To Conception And Birth Defects, National Birth Defects Prevention Study, 1997-2011, Richard Finnell, Nithya Lakshmi Mohan Dass, Eirini Nestoridi, Marcia C De Oliveira Otto, Julie Peterson, Tunu Ramadhani, Mark A Canfield

Faculty, Staff and Students Publications

Background: Epidemiologic data on the association between maternal fish intake and birth defects are sparse. Our objective was to assess associations between maternal fish intake and 52 different birth defects, most of which have not been assessed previously.

Methods: Using logistic regression, data was analyzed for 29,242 mothers of infants with birth defects and 10,973 mothers of control infants who participated in the National Birth Defects Prevention Study (NBDPS) and delivered between 1997 and 2011. We focused on associations between mothers who reported high fish intake of 2 or more servings of fish per week for the year prior to …

Bridging Access Gaps In Radiotherapy: Knowledge-Based Planning In A Resource-Constrained Clinical Setting, Baozhou Sun, James A Kavanaugh, Taoran Li, Angel Velarde, Vicky De Falla, Francisco Reynoso

Faculty, Staff and Students Publications

Background/purpose: Radiotherapy access in low- and middle-income countries (LMICs) is severely limited by shortages of trained personnel, high patient volumes, and large waiting times for manual treatment planning. Knowledge-based planning (KBP) has shown promise in high-income settings, yet its feasibility in resource-constrained environments remains underexplored. This study aimed to evaluate the feasibility of adapting a KBP model developed at a high-income institution for clinical use at Liga Nacional Contra el Cáncer (LNCC) in Guatemala for gynecological radiotherapy planning.

Materials and methods: A RapidPlan KBP model (Varian-Siemens Healthineers, Palo Alto, CA, USA) originally developed at Washington University in St. Louis using …

Fructose: Metabolic Signal And Modern Hazard, Marcus D Goncalves, Samir Softic, Kimber L Stanhope, Laura G Sánchez-Lozada, Mark A Herman, Joshua D Rabinowitz

Faculty, Staff and Students Publications

There is much interest in the role of sweeteners such as table sugar (sucrose) and high-fructose corn syrup in obesity and metabolic disease. Both sweeteners consist of glucose and fructose, two six-carbon isomeric sugars. Whereas glucose ingestion may promote obesity through its effects to stimulate insulin secretion, fructose has unique metabolic effects that promote triglyceride synthesis and fat accumulation. These effects arise from fructose's well-known role as a signal of metabolic plenty. Under modern conditions of overnutrition, chronic excess fructose drives features of metabolic syndrome. Emerging evidence further links fructose to cancer and dementia. Here we review the biochemical, molecular …

A Smoking-Related Plasma Protein Score And Smoking-Related Cancer Risk And Mortality In The Atherosclerosis Risk In Communities Study, Hana Zahed, Christie M Ballantyne, Kenneth R Butler, Josef Coresh, David J Couper, Panagis Galiatsatos, Marc J Gunter, Ron C Hoogeveen, Mattias Johansson, Corinne E Joshu, P Martijn Kolijn, Christina M Lill, Jiayun Lu, Michael T Marrone, Giovanna Masala, David C Muller, Anna E Prizment, Raul Zamora-Ros, Nilanjan Chatterjee, Adrienne Tin, Elizabeth A Platz

Faculty, Staff and Students Publications

Background: Self-reported smoking may not fully capture individualized risk of smoking-related cancer, but circulating proteins may reflect biological consequences of smoking. Thus, we developed a score based on smoking-related proteins and evaluated its association with smoking-related cancer.

Methods: This prospective cohort study included 10 563 participants aged 47-70 years in the Atherosclerosis Risk in Communities study. Plasma proteins were measured using the SomaScan Platform (SomaLogic Operating Co, Inc). The score was constructed from proteins associated with current smoking, pack-years, or recent quitting identified by linear regression and elastic net regression. Cox regression was used to estimate adjusted hazard ratios and …

Noncanonical Clock Regulators Control Stress Responses In Digestive Diseases, Dongyin Guan

Faculty, Staff and Students Publications

The digestive system is essential for nutrient absorption, processing, and waste elimination. The expression of many genes and physiological processes within this system exhibits a 24-h rhythmicity. However, modern lifestyle factors, such as jet lag, shift work, and irregular eating patterns, significantly disrupt these rhythms, triggering various stress responses and contributing to numerous digestive disorders. Here, we focus on emerging studies on noncanonical clock regulators involved in stress responses, integrate these novel findings into the established model of the core circadian clock, and highlight recent advances in the development of novel therapeutics targeting these 24-h regulators. In addition, we discuss …

Mif-Cd74 Signaling Drives Immune Modulation In Medulloblastoma, Xu Guo, Alaide Morcavallo, Diego Chillon Pino, Carlos Lorenzo Gido Nery, Sumana Shrestha, Chantelle E Bowers, Courtney Himsworth, Alberto Delaidelli, Bethany Remeniuk, Sonia Morlando, Brandon Wade, Freya Gordon, Yara Sanchez-Corrales, Bei Hopkins, Natalie Monteiro, Darren Locke, Miao Liu, Jacob Torrejon Diaz, Kevin Greenslade, Barbara Martins Da Costa, Karen Barker, Colin Kwok, Olumide Ogunbiyi, Anya Fletcher, Stacey Richardson, Carlos Custodia, Rafael Roque, Thomas Jackson, Regan Barfoot, Sergi Castellano, Rebecca M Hill, Olivier Saulnier, Thomas S Jacques, Michael D Taylor, Claudia C Faria, Olivier Ayrault, Poul H Sorensen, John Anderson, Louis Chesler, L Frank Huang, Steven C Clifford, Laura K Donovan

Faculty, Staff and Students Publications

Background: Relapsed medulloblastoma remains a significant therapeutic challenge as it is near universally fatal. The tumor microenvironment of medulloblastoma plays a critical role in tumor progression, influencing tumor growth, immune evasion, and therapeutic resistance. We hypothesized that defining tumor-immune interactions in diagnostic and relapsed medulloblastoma may uncover mechanisms of immune evasion and identify novel therapeutic targets.

Methods: We analyzed paired primary and recurrent RNA-sequencing data from 140 medulloblastoma patients to profile immune cell composition and validate spatial relationships within the TME. To identify key tumor-immune interactions, we developed a novel algorithm to detect receptor-ligand pairs using single-cell RNA-sequencing data. These …

Hiding In Plain Sight: A Call To Prevent Cutaneous Leishmaniasis Transmission In The United States, Norman Beatty, Dawn M Wetzel

Faculty, Staff and Students Publications

Cutaneous leishmaniasis (CL), once considered a travel-associated tropical disease, is increasingly transmitted within the United States, particularly in southern regions. Despite mounting evidence of local transmission, public health recognition and preventive infrastructure remain limited. This Viewpoint highlights the urgent need to shift the U.S. CL response from questioning endemicity to preventing transmission. We review ecological, clinical, and surveillance data demonstrating the presence of competent vectors, animal reservoirs, and autochthonous human cases. Diagnostic delays, underreporting, and insufficient provider training contribute to missed prevention opportunities. Climate change and peri-urban rodent-human contact data further heighten future risk. A coordinated response is essential, including …

Dolutegravir Developmental Toxicity Is Mitigated By Magnesium And Folate In Zebrafish Embryos, Katheryn A Neugebauer, Daniel A Gorelick

Faculty, Staff and Students Publications

Integrase strand transfer inhibitors have transformed human immunodeficiency virus (HIV) therapy, yet the widely prescribed drug dolutegravir (DTG) has been linked to developmental toxicity, and its teratogenic mechanism remains unclear. Here, we used zebrafish to dissect DTG toxicity during early vertebrate development. DTG exposure from 2-4 h post-fertilization (hpf) to 24 hpf produced high mortality and abnormal morphology. Co-treatment with folates partially restored normal morphology, whereas calcium had no effect. Strikingly, supplementation with magnesium (Mg) partially rescued DTG-exposed embryos, implicating Mg availability in protection. In competitive binding assays, Mg increased binding of folate to purified folate receptor (FOLR1) by 30% …

Adhesion G Protein-Coupled Receptors, Gabriela Aust, Monserrat Avila-Zozaya, Sofie Morsing Bagger, Patrick Barth, Sandra Berndt, Stephen C Blacklow, Beatriz Blanco-Redondo, Antony A Boucard, James P Bridges, Lara-Sophie Brodmerkel, Kathleen M Caron, Yin Kwan Chung, Andrew N Dates, Virginea De Araujo Farias, Daniel Del Toro, Joseph G Duman, Felix B Engel, David M Favara, Caroline J Formstone, Chaoyu Fu, Alain Garcia De Las Bayonas, Anastasia Georgiadi, David E Gloriam, Randy A Hall, Jörg Hamann, Peter W Hildebrand, Cheng-Chih Hsiao, Bill X Huang, Jonathan A Javitch, Hee-Yong Kim, Robert J Kittel, Gunnar Kleinau, Richard Leduc, Ines Liebscher, Hsi-Hsien Lin, Joshua Linnert, Marie-Gabrielle Ludwig, David C Martinelli, Signe Mathiasen, Daniel Matúš, Mariam Melkumyan, Ana L Moreno-Salinas, Jan Mulder, Michael A Nash, Kasturi Pal, Daniel T Pederick, Nicole A Perry-Hauser, Xianhua Piao, Yu-Qi Ping, Dimitris G Placantonakis, Fabian Pohl, Simone Prömel, Mette M Rosenkilde, Laurent Sabbagh, Richard C Sando, Patrick Scheerer, Torsten Schöneberg, Elena Seiradake, Mareike Selcho, Florian Seufert, Abhishek K Singh, Georgios Skiniotis, Katja Spiess, Norbert Sträter, David Strutt, Thomas C Südhof, Jinpeng Sun, Gregory G Tall, Doreen Thor, Douglas G Tilley, Kimberley F Tolias, Mario Vallon, Erwin G Van Meir, Benoit Vanhollebeke, Giselle R Wiggin, Uwe Wolfrum, Jie Yan, Nathan A Zaidman, Yimin Zou, Nicole Scholz

Faculty, Staff and Students Publications

Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive …

Exploring Bidirectionality In Global Health Partnerships: Perspectives From U.S. Pediatric Residency Programs, Ashley Combs, Adelaide Barnes, Kathy Ferrer, Heather Haq, Duncan K Hau, Lee Morris, Brittany Murray, Amy Rule, Reena P Tam, Lisa Umphrey, Megan S Mchenry

Faculty, Staff and Students Publications

Introduction Despite growing interest, little guidance exists to re-evaluate global health partnerships (GHPs) through promoting bidirectionality. This study aims to understand the perspectives of United States (U.S.) pediatric global health (GH) faculty on institutional bidirectional practices to inform future discussions with international collaborators. Methods An internally, iteratively developed REDCap-based online survey (REDCap, Vanderbilt University, Nashville, TN), by our diverse author group, collected qualitative data from January 18 to February 20, 2023. Free-text responses were reviewed and coded inductively, with findings framed to generate themes for subsequent engagement with international partners. Results Of the 88 U.S. programs that identify as having …

Pulse Wave Velocity In Atrial Fibrillation: A Scoping Review Of Clinical Relevance, Oren G. Nedjar, Zaneh Kahook, Syed Maaz Shah, Christos G. Mihos, Marc M. Kesselman

Student Publications

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with high morbidity, mortality, and healthcare burden. Arterial stiffness (AS) alters cardiac loading conditions and contributes to ventricular arterial uncoupling (VAC), diastolic dysfunction, and atrial remodeling. Pulse wave velocity (PWV) is the standard noninvasive measure of AS, but its role across the spectrum of AF has not been clearly defined. This scoping review assessed the existing literature on PWV and AF, with attention to disease onset, clinical characteristics, progression, treatment response, and outcomes. A scoping review was conducted following Preferred Reporting Items for Systematic reviews and Meta-Analyses …

Clinical And Demographic Characteristics Of Hospitalized Patients With Xylazine-Related Wounds, Elizabeth Novick, Nikhil Seval, Dagan Coppock, Mollie Tucker, Daniel Taupin, John Zurlo, Carolyn Kramer

Department of Medicine Faculty Papers

OBJECTIVES: Little is known about the demographic and clinical features of patients with xylazine-related wounds. We sought to characterize hospitalized patients with substance use disorder (SUD) and xylazine-related wounds seen for infectious diseases consultation.

METHODS: We retrospectively reviewed the medical records of 193 patients diagnosed with SUD at 3 Philadelphia hospitals between October 2023 and January 2024. Patients were identified as either being diagnosed with (n=73) or without (n=120) xylazine-related wounds. We compared the demographic and clinical features between the 2 groups.

RESULTS: Patients diagnosed with wounds were younger ( P < 0.001), more likely to be White or Hispanic and less likely to be Black/AA ( P < 0.001), more likely to have tested positive for fentanyl ( P < 0.001), amphetamines ( P < 0.001), and cocaine ( P 0.001), more likely to acknowledge injection ( P < 0.001), and more likely to leave the hospital by patient-directed discharge (PDD) ( P < 0.001). Most patients had multiple wounds (75%), and more than half (53%) had at least one wound greater than 10 cm at its widest dimension. Although most patients diagnosed with wounds received antibiotics, many did not have symptoms or signs of infection.

CONCLUSIONS: Xylazine-related wounds are highly associated with illicitly manufactured …