Digital Commons Network^™

Re: Request For Change To The Butte Priority Soils Operable Unit Clark Tailings Consolidated Waste Management Area Site Investigation Quality Assurance Project Plan Revision 0 (2026 Update), Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Medetomidine As A Fentanyl Adulterant: Pharmacology, Detection, Clinical Presentation, And Management, Kory S. London, Phil Durney, Brendan Hart, Ashish Thakrar, Dennis Goodstein, Alex J. Krotulski, Daniel Teixeira Da Silva, Joseph D’Orazio, Lara Weinstein, Jeanmarie Perrone, Michael J. Lynch

Division of Internal Medicine Faculty Papers & Presentations

Purpose of Review Medetomidine is a veterinary α2-adrenergic agonist that has been an adulterant of illicitly manufactured opioids since 2022. We review its pharmacology, detection, intoxication, withdrawal, and management, and assess why severe withdrawal has emerged in some regions but not others. Recent Findings Medetomidine has spread through North American drug markets yet evades most toxicology testing. Roughly two hundred times more potent than xylazine, with greater α2 selectivity and imidazoline-1 activity, it causes intoxication resembling other α2 agonists: sedation and bradycardia. The dominant clinical problem is withdrawal: autonomic dysregulation, intractable vomiting, and encephalopathy frequently requiring intensive care. Treatment requires …

The Tragicomedy Of C. S. Lewis The Bald: Reflections On An Unpublished Play, Jahdiel Perez

Sehnsucht: The C. S. Lewis Journal

"Within the pages of a Vice-President’s Register (1920–1984), held in the Old Library archives of his Oxford College, Lewis handwrote, in mock Shakespearean English, 'The Tragicomicall Briefe Reigne of Lewis the Bald.' As far as we know, this is the only complete play in his corpus. Mostly unpublished until the recent release of C. S. Lewis’s Oxford (2024) by Simon Horobin, this piece has yet to receive the scholarly attention it deserves. In what follows, I seek to address this gap through a close analysis of portions of the text and its broader implications for Lewis’s approach to writing."

A Moving Image Of Eternity: Exploring C. S. Lewis's Philosophy Of Time, Brian C. Roden

Sehnsucht: The C. S. Lewis Journal

"The “Time Graph,” as it will be labeled in this essay, is obscurely nestled in C. S. Lewis’s personal manuscripts held in the Bodleian Library at the University of Oxford. Comprised of mathematical sketches and cryptic commentary, the document has apparently escaped formal study regarding why Lewis produced it or how it might relate to his published works. More broadly, does it have any bearing on a coherent philosophy of time that Lewis may have held? The aim of this essay is to demonstrate that the Time Graph is very likely an early draft of the mechanics of time travel …

The Mythos Of Gender In Till We Have Faces, Annie Crawford

Sehnsucht: The C. S. Lewis Journal

"In Till We Have Faces, C. S. Lewis draws from the mythic imagery of Cupid and Psyche to offer a potent meditation on the symbolism of gender. Through the recurring imagery of mountain, temple, and womb, Lewis reinterprets classical archetypes within a Christian imagination to reveal gender not as a social construct or biological accident but as a spiritual polarity woven into the fabric of creation. In this symbolic cosmos, mas- culinity and femininity signify the dynamic interplay of divine initiative and creaturely receptivity—the eternal rhythm of giving and receiving that structures both nature and grace. Read in this light, …

Screwtape In Wartime, Joe Ricke

Sehnsucht: The C. S. Lewis Journal

"This essay looks closely at the connections between Lewis’s wartime message to his listeners in his now famous, but then unlikely, sermon, “Learning in Wartime,” on 22 October 1939 and his wartime novel, The Screwtape Letters. It will range widely from biography to history to literary influences and to close reading of the texts to help reflect on its place not only in Lewis’s oeuvre but in his life and the lives of all those who, then and now, attend to the distinction between what Lewis (and, surprisingly, Screwtape) makes between the local wars of time and space and the …

Predictive Single-Tap Task Completion, Marc Stogaitis, Mimi Sun

Defensive Publications Series

This disclosure describes techniques that enable a computing device (e.g., a smartphone or other mobile computing device) to present a single smart button or predictive UI element that predicts and automatically completes a task on the user's behalf. This prediction may be based on contextual signals the computing device logs over time, such as accessibility events, notifications, location, time of day, and a recognized activity of the user (e.g., walking, driving, or sitting still). Using these signals and a large language model (LLM), the computing device may learn to distinguish discrete, repeatable tasks appropriate for single-tap completion (e.g., opening a …

Gc-Ms Profiling And Antibacterial Activity Of Cold-Macerated Garlic Extracts Against Multidrug-Resistant Uropathogens, Fatima A. Khalaf, Saeed A. Fayadh

Karbala International Journal of Modern Science

The growing number of cases of multidrug-resistant (MDR) urinary tract infections has made the clinical management of urinary tract diseases a significant challenge; therefore, the need for effective adjunctive therapies cannot be overemphasized. This study evaluated the bioactive components and antibacterial efficacy of cold-macerated garlic extracts obtained using distilled water, 70% ethanol and hexane solvents against antimicrobial-resistant urinary isolates. Out of 250 urine samples that were analyzed, 124 (49.6%) showed significant microbial growth, with Escherichia coli being the most frequently isolated organism. The results of the phytochemical screening and Gas Chromatography-Mass Spectrometry (GC-MS) analysis showed that the ethanolic extract had …

Hyperlattice-Valued And Superhyperlattice-Valued Uncertain Sets With Decision Applications, Takaaki Fujita, Ajoy Kanti Das, Sankar Prasad Mondal, Arif Mehmood, Arkan Ghaib

Neutrosophic Systems with Applications

Fuzzy set theory enriches classical sets by assigning to each element a graded membership in [0,1], thereby capturing partial inclusion and uncertainty. The notion of an Uncertain Set further abstracts this idea by allowing membership to take values in a general degree-domain, providing a unified language that subsumes fuzzy, intuitionistic fuzzy, neutrosophic, plithogenic, and related models. On the algebraic side, a hyperlattice replaces one lattice operation by a multivalued hyperoperation, enabling the representation of ambiguous or non-deterministic combinations, while a superhyperlattice iterates this structure through powerset lifting to obtain higher-order layers of interaction. Motivated by these developments, we introduce HyperLattice-valued …

A Unified Framework For Neutrosophic Estimation Using Fractional Power, Exponential, And Logarithmic Functions With Bivariate Auxiliary Information, Anchal Yadav, Anuj Yadav

Neutrosophic Systems with Applications

This study develops a generalized neutrosophic ratio-type estimator for estimating the population mean by incorporating information from two auxiliary variables under Simple Random Sampling Without Replacement (SRSWOR). The proposed methodology extends the conventional single-auxiliary-variable approach by jointly incorporating bivariate auxiliary information within the neutrosophic framework, thereby accounting for uncertainty, indeterminacy, and inconsistency in the available information. The bias and mean squared error of the proposed estimator are derived using first-order approximations, and the corresponding efficiency conditions are established through theoretical comparisons with existing neutrosophic estimators. The performance of the proposed estimator is further examined using a real medical dataset represented …

20 Years Of Neutrosophic Statistics: A Bibliometric Analysis, Hammad Khalid, Arshad Hameed

Neutrosophic Systems with Applications

Florentin Smarandache introduced neutrosophic statistics (NS), a formalism for representing uncertainty and indeterminacy in observations, parameters and statistics in an extension to classical and interval statistics. Although widespread in various contexts, such as statistical quality control, hypothesis testing, medical diagnosis, and decision science, and increasingly used and developed, the scientific evolution and conceptual framework of the science of decision making remain largely unexamined. To fill this gap, the present study has been conducted with a comprehensive bibliometric analysis of NS research articles published between 2003 to 2025 from Scopus which has been conducted following the SPAR-4-SLR protocol. In all, 501 …

The Forest's Gift: Ritual Resilience, Nature, And Faith In The Malay Postpartum Tradition Of Pelimau Dapur, Nurul Asmaa Akmal Md Din, Sri Qamariah Mohd Samsir, Awang Azman Awang Pawi, Tengku Intan Marlina Tengku Mohd Ali, Nurul Haniza Samsudin

Forest and Society

This article examines pelimau dapur, a Malay post-confinement ritual practised by some families in Kampung Alor Limbat, Terengganu. It investigates how ritual knowledge is transmitted, how natural and processed materials acquire cultural, spiritual, and perceived therapeutic meanings, and how the practice is reshaped by religious, social, healthcare, and material change. The study employed a focused ethnographic case study design involving semi-structured interviews with eight purposively selected participants (two traditional midwives and six women with direct experience of the ritual), together with participant observation, field notes, and visual documentation. The data were analysed thematically. The findings show that pelimau dapur …

Effect Of Black Soldier Fly Larvae Meal (Hermetia Illucens) And Microbial Probiotics With Multi-Enzymes On Protein Efficiency Ratio, Metabolic Profile, And Immune Status Of Broiler Chickens, Ahmed Abd-Elaziz Abdallah, Mona. Mahmoud Ahmed, Mohamed Mowed Khalifah, Marwa Ramdan El-Deken, Bahaa Mohamed Abou-Shehema, Mohamed Elsaeid Farag, Afaf Bobaker Abu_Shouk, Reda Mohamed Zaki, Asmaa Ahmed Saad, Merfat Salah El-Deen, Mervat A. Berikaa

Journal of King Abdulaziz University: Meteorology, Environment and Arid Land Agriculture

Black soldier fly larvae meal (BSFLM; Hermetia illucens) has been authorized in the EU as an insect-derived protein for feed and is a promising alternative to soybean meal (SBM), with potential functional benefits attributed to lauric acid (LA), chitin, and bioactive peptides; however, evidence is limited regarding its interaction with probiotic–multi-enzyme complexes. Thus, we investigated whether replacing SBM with BSFLM, with or without a microbial probiotic and multi-enzyme blend (MPE). A total of 225 one-day-old Ross 308 chicks were allocated to nine treatments in a 3× 3 factorial design (five replicates of five chicks) from 1–38 d, using mash …

Unsex Me Here: Gendered Psychology In Shakespeare's Major Tragedies And Comedy, Md. Abu Bakkar

Journal of Language, Literature, and Arts

This study examines how gender shapes psychological experience across five of Shakespeare’s major plays: Macbeth, Hamlet, Othello, King Lear, and Twelfth Night. Existing scholarship treats Shakespeare’s tragic women, tragic men, and comic heroines as separate problems; this article asks whether one framework connects them. Its starting point is the reversal in psychological positions between Macbeth and Lady Macbeth: he resists killing on moral grounds and then grows recklessly violent, while she plans the murder with cold resolve and is later overwhelmed by guilt. The study asks whether this pattern recurs more broadly, and why. Drawing …

Prevalence And Characteristics Of Feline Pleural Effusion In Khon Kaen, Thailand: A 2024–2025 Study, Karn Yongvanit, Naruepon Kampa

The Thai Journal of Veterinary Medicine

Pleural effusion (PE) is a life-threatening condition in cats that can cause severe respiratory compromise. Identification of the underlying etiology is essential for prognosis and treatment planning. This study investigated the prevalence and characteristics of diseases associated with feline pleural effusion in northeastern Thailand. Medical records of cats diagnosed with pleural effusion at the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Khon Kaen University, Thailand, between January 2024 and January 2025 were retrospectively reviewed. Cases lacking a complete diagnostic workup were excluded. Diagnoses were confirmed using cytology or histopathology for neoplasia, echocardiography for heart disease, polymerase chain reaction (PCR) for …

Flipbook-Based Media To Prevent Academic Burnout Among Senior High School Students In Yogyakarta, Puan Maharani Fauza, Eva Imania Eliasa, Kun Widya Nurfiani

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Academic burnout is a pressing issue that negatively affects senior high school students, yet conventional counseling services often rely on monotonous, static media that fail to engage today's digital generation. To address this urgent gap, this research aimed to develop an interactive digital Flipbook as a preventive intervention. The study employed a Research and Development (R&D) method using the ADDIE model, consisting of Analysis, Design, Development, Implementation, and Evaluation stages. Product validation was conducted by media experts and subject-matter experts, while the practicality test involved two Guidance and Counseling teachers. The effectiveness test was carried out through an experimental study …

Neuroimmune Phenotyping As The Next Frontier In Chronic Pain Medicine For Musculoskeletal Back Pain, Samer G. Salman, Rohan A. Phadke, Adithya Nair, Rahul Kumar, Arbaz Momin, Alireza Tavakkoli, James Rizkalla

Department of Neurosurgery Posters

Background: Chronic low back pain encompasses heterogeneous mechanical, neuropathic, nociplastic, and myofascial presentations that may reflect distinct neuroimmune mechanisms. We synthesized evidence linking these phenotypes to measurable biological features and clinically relevant treatment strategies.

Methods: We conducted a structured literature search of MEDLINE, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials for studies published from January 2005 through January 2025. Systematic reviews, randomized controlled trials, and mechanistic studies addressing neuroinflammation, glial activation, central sensitization, biomarkers, or imaging were organized according to four clinically relevant pain phenotypes and translational readiness.

Results: Neuroimmune findings differed across axial mechanical, …

Sit, Stay, Overturn: How New Canine Science Is Challenging Courtroom Convictions, Kerolls Gadelrab

Georgia Criminal Law Review

Courts increasingly rely on cadaver dog evidence in criminal trials, treating canine alerts as a reliable form of forensic evidence. This naive acceptance of cadaver dog evidence, coupled with courts’ continued application of out-dated admissibility standards, threatens to perpetuate wrongful convictions in an era of rapidly advancing scientific understanding. This Article argues that courts must develop a new framework for evaluating cadaver dog evidence that incorporates modern scientific research on ca-nine olfaction and scent detection capabilities. While scholars have extensively analyzed various forensic evidence standards post-Daubert, the literature has largely over-looked how recent scientific advances in understanding ca-nine olfaction should …

Acute Liver Injury Likely Induced By Alpha Lipoic Acid Contained In Dietary Supplement, Simona Maksimyan, Jonathan V. Reyes, Kasim Kazbay, Farah K. Gazi

Journal of Community Hospital Internal Medicine Perspectives

The rise in use of herbal and dietary supplements, which are regulated as food rather than as drugs by the Food and Drug Association, poses the risk of unknown and potentially severe side effects. We describe the case of acute liver injury, characterized by significant elevation in AST and ALT, likely induced by the consumption of an over-the-counter supplement containing alpha lipoic acid (ALA). Our patient trusted in a “natural” alternative to Western medicine for management of neuropathy, which was ultimately detrimental to her liver. An immediate and sustained improvement in liver enzyme levels was noted with discontinuation of the …

Context-Aware Semantic Method And System For Network-Connected Camera Notification Filtering, Josh Och, Andrew Axley

Defensive Publications Series

A system and method are provided for enhancing the operational intelligence of network-connected cameras through the establishment of camera-specific semantic context. A digital repository is associated with an individual monitoring device to store context metadata representing physical and logical relationships in the device's field of view. The context metadata can be defined via user input or automatically inferred using analytical models that identify historical activity patterns or process environmental feedback. When a monitoring event occurs, the associated context metadata is retrieved and integrated into an evaluation framework, such as an augmented prompt for a generative artificial intelligence model, to analyze …

Rachel's Quest, William Lindsey Mcdonald

Correspondence

Letter from William Lindsey McDonald to Rachel, with an unlisted last name, in response to the question "who is Piedmont?" McDonald's answer endeavors to stretch across time and becomes philosophical at times. To the outsider, it would appear that McDonald was answering an inquiry about the Piedmont plateau region within the Eastern United States, a relevant subject for a local historian who often described geography. However, McDonald is instead telling about the somewhat humorous existence of an "old owl" that inhabited his childhood.

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Kant, Stephan Körner

Hannah Arendt Marginalia - All

Harmondsworth ; Middlesex : Penguin Books, 1955.

Call #: B2798 .K6

Contains underlining  PDF information: 15 pages - 5.5 MB

Paradoxical Reaction Presenting As Sacroiliitis In Brucellosis: A Case Report And Literature Review, Azer Karaman, Sümeyye Bayram, Hatice Gaber Kurt

Journal of Pediatric Infectious Diseases

Although brucellosis is one of the most common zoonotic infections worldwide, the development of a paradoxical reaction during treatment hasrarely been reported in the literature. We present a 17-year-old patient who developed acute sacroiliitis in the second week of treatment for olecranon bursitis brucellosis, despite her initial clinical findings showing signs of improvement. After excluding other potential etiologies for sacroiliitis, clinical and radiological recovery was achieved by adding anti-inflammatory therapy without modifying the existing antimicrobial regimen. Consequently, the clinical picture was evaluated as a paradoxical reaction. This case emphasizes that new symptoms or clinical worsening during brucellosis treatment should not …

Analysis Of Risk Factors And A Predictive Model For Recurrent Febrile Seizures Within A Single Febrile Illness In Children, Zheng Ge, Pao Yu, Kun Chen, Bi Zhou

Journal of Pediatric Infectious Diseases

Objective: To investigate predictive factors for seizure recurrence in children with febrile seizures (FS) within a single febrile illness, providing a basis for early clinical identification and preventive measures. Methods: We conducted a retrospective analysis of children with FS admitted to the Department of Pediatrics, Suzhou Hospital Affiliated to Anhui Medical University, from April 2023 to December 2025. A total of 337 children met the inclusion criteria. Children with more than one seizure within the same febrile ilness were classified as the recurrent febrile seizures (RFS) group, and those with a single seizure as the non-recurrent febrile seizures (NRFS) group. …

Identification Of Ca2 As A Potential Candidate Gene Involved In The Therapeutic Effect Of Huatan Huoxue Decoction On Polycystic Ovary Syndrome: An Integrated Study Of Network Pharmacology, Mendelian Randomization, And Experimental Validation, Chan Zhu, Yijin Zhang, Panwei Hu, Cong Qi, Qiu Chen, Hong Yang, Jing Li

Journal of Food and Drug Analysis

Purpose: Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Methods: Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for PCOS from the FinnGen R12 database. These targets were integrated with the active ingredients and protein targets of HTHXD retrieved from the TCMSP and BATMAN-TCM databases for network pharmacology analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted. Core targets were validated using molecular docking. Experimental validation was performed using a letrozole-induced …

Impact Of The Widespread Use Of Online Pharmacies On Overall Consumer Safety, Hasanain Am. Abbas, Eswar Kumar Kilari, Shereen M. Mekkey, Hussein Ahmed Jabbar, Mohammed Haider Majid, Haider Majeed Abd Abbas, Hassanein Khaled Hassan

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Online pharmacies improve access to medicines by offering convenient ordering and home delivery, but their growth also creates important risks for medication safety and public health. This review examines the benefits and hazards associated with online medicine supply, including access without a valid prescription, falsified and substandard products, inappropriate medicine use, privacy breaches, and weak cross-border regulatory oversight. The available evidence indicates that illicit online sellers can expose consumers to products of uncertain identity, quality, and dose, while vulnerable users may have limited ability to distinguish legitimate services from unlawful vendors. At the same time, licensed platforms can support continuity …

Preparation And In Vitro Evaluation Of Gastro-Retentive Tablets Of Frusemide Using Gas Generating Excipients As Floating Mechanism, Yousif K. Younis, Ahmed Yousif Fadhel, Nihad Hussein Ahmed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Frusemide is a loop diuretic used for hypertension, heart failure among many other indications. It has an absorption window in the stomach and it's a class IV drug according to BCS with low bioavailability.
Floating tablets are one of the dosage forms that is best suited for drugs with such absorption window and gas generating excipients can be used to reduce floating lag times even more than traditional floating tablets that relay on density difference alone.
The aim of the study was to investigate the feasibility of floating tablets as a convenient dosage form for oral administration of frusemide aiming …

Current Advances In Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, And Future Perspectives, Mohamed E. Abd El-Hack, Mahmoud Moustafa, Mahmoud Kamal, Vincenzo Tufarelli, Muhammad Arif, Laith Aldabbagh

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Cancer immunotherapy has emerged as a transformative therapeutic strategy that harnesses the host immune system to recognize and eliminate malignant cells. This review provides a comprehensive overview of current immunotherapeutic approaches, including immune checkpoint inhibitors (ICIs), monoclonal antibodies (mAbs), cancer vaccines, dendritic cell (DC)-based vaccines, chimeric antigen receptor (CAR)-T cell therapy, and oncolytic virus therapy. The mechanisms of action, therapeutic applications, and clinical benefits of each modality are discussed. Monoclonal antibodies selectively target tumor-associated antigens, whereas ICIs restore antitumor immunity by blocking inhibitory immune checkpoints. Cancer vaccines and DC-based vaccines enhance antigen-specific immune responses, while CAR-T cell therapy employs genetically …

Complementary Vertebrate Wac Models Exhibit Phenotypes Relevant To Desanto-Shinawi Syndrome, Kang-Han Lee, Marwan Shinawi, Et Al.

2020-Current year OA Pubs

Monogenic syndromes are associated with neurodevelopmental changes that result in cognitive impairments and neurobehavioral phenotypes, including autism and seizures. Limited studies and resources are available to make meaningful headway into the underlying molecular mechanisms that result in these symptoms. One such example is DeSanto-Shinawi Syndrome (DESSH), a rare disorder caused by pathogenic variants in the