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2026

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Evaluating The Reproducibility And Verifiability Of Nutrition Research: A Case Study Of Studies Assessing The Relationship Between Potatoes And Colorectal Cancer, Yasaman Jamshidi-Naeini, Colby J Vorland, Pranav Kapoor, Bailey Ortyl, Jocelyn Mineo, Luke Still, Korlu Sorsor, Shelby Rodney, Xander Tooze, Brent Flickinger, Beate Henschel, Stephanie L Dickinson, David B Allison Jun 2026

Evaluating The Reproducibility And Verifiability Of Nutrition Research: A Case Study Of Studies Assessing The Relationship Between Potatoes And Colorectal Cancer, Yasaman Jamshidi-Naeini, Colby J Vorland, Pranav Kapoor, Bailey Ortyl, Jocelyn Mineo, Luke Still, Korlu Sorsor, Shelby Rodney, Xander Tooze, Brent Flickinger, Beate Henschel, Stephanie L Dickinson, David B Allison

Faculty, Staff and Students Publications

The credibility of nutritional research is dependent on the rigor with which studies are conducted and the ability for independent assessment to be performed. Despite the importance of these, more work is needed in the field of nutrition to buttress the trustworthiness of nutrition research. To develop and apply a process for evaluating the rigor, reproducibility, and verifiability of nutritional research, using the relationship between potato consumption and Colorectal Cancer (CRC) as a case study. We updated existing systematic reviews to include studies on potatoes and CRC, assessing their design, execution, and reporting quality. We attempted to reproduce and verify …


Movement Ecology And Population Dynamics Of Box-Nesting Black-Bellied Whistling-Ducks (Dendrocygna Autumnalis) In Louisiana, Katie E. Miranda Jun 2026

Movement Ecology And Population Dynamics Of Box-Nesting Black-Bellied Whistling-Ducks (Dendrocygna Autumnalis) In Louisiana, Katie E. Miranda

LSU Master's Theses

Understanding demographic and behavioral processes underlying population dynamics is essential for effective wildlife management, especially for species subject to harvest pressure or experiencing population shifts. Black-bellied Whistling-Ducks (Dendrocygna autumnalis) are currently undergoing a notable northward range expansion and are increasing in abundance across the southeastern United States, raising management concerns for both ecological and economic reasons. As a result, there is growing public support for a special Black-bellied Whistling-Duck-specific harvest season, yet little research has been conducted on this species, particularly within newly-established populations. To address this gap, I conducted this study with the goal of evaluating seasonal …


Elevated Phagocytic Capacity Directs Innate Spinal Cord Repair, Dana Klatt Shaw, Vishnu Muraleedharan Saraswathy, Anthony R Mcadow, Lili Zhou, Dongkook Park, Ridim Mote, Amulya Saini, Ashley J Douthitt, Katerina Stepankova, Brittney Unverzagt, Cédric G Geoffroy, Aaron N Johnson, Mayssa H Mokalled Jun 2026

Elevated Phagocytic Capacity Directs Innate Spinal Cord Repair, Dana Klatt Shaw, Vishnu Muraleedharan Saraswathy, Anthony R Mcadow, Lili Zhou, Dongkook Park, Ridim Mote, Amulya Saini, Ashley J Douthitt, Katerina Stepankova, Brittney Unverzagt, Cédric G Geoffroy, Aaron N Johnson, Mayssa H Mokalled

2020-Current year OA Pubs

Immune cells elicit a continuum of transcriptional states after spinal cord injury (SCI). In mammals, inefficient debris clearance and chronic inflammation impede recovery and overshadow pro-regenerative immune functions. We found that zebrafish SCI elicits transient immune activation and efficient debris clearance. Transcriptomics and genetic ablation showed zebrafish macrophages are highly phagocytic and required for regeneration. Comparisons between zebrafish and mammalian macrophages identified transcription and immune response regulator (tcim) as an immune-enriched regenerative gene. Deletion of zebrafish tcim impairs phagocytosis and regeneration and activates a pro-inflammatory signature in leukocytes. Tcim expression in zebrafish and mouse macrophages establishes its conserved roles by …


The Matrix, Spring 2026, The Women's Resource Center Jun 2026

The Matrix, Spring 2026, The Women's Resource Center

The Matrix

Matrix Editor: Trinity Sue

Women's Resource Center Advisor: Marisol Ruiz

Women's Resource Center Staff (listed alphabetically):

  • Namixtu'lu' Esteva
  • Pamela Hernandez
  • Kaylee Luna
  • Izzie Rodríguez-Torres
  • Alexis Sarmiento
  • Venus Shearer
  • Trinity Sue

Authors/Illustrators in issue (listed alphabetically):

  • Megan Atherton, p. 11
  • Brenna, p. 24
  • Jess Carey, p. 17
  • Leyla Craven, p. 20
  • Annabelle Davis, p. 37
  • Erica Drew, p. 18
  • Sage Fowler, p. 11
  • Aven Gehlert, p. 30
  • Emily Hartling, p. 24
  • Riley Hemenover, p. 12
  • Pamela Hernandez, p. 14
  • Ella Humphrey, pp. 22-23, 31, 35, and throughout
  • Iran@alittlepoke, p. 13
  • Kaylee Luna, pp. 25, 29
  • Randi Maveety, p. 34
  • Xenia McLean, …


Freshwater Harmful Algal Blooms (Habs) Public Health Message Efficacy Evaluation, Alexandra Benitez Gonzalez, Heather A. Triezenberg, Diane Doberneck, Abigail Bennett, Mark Rey Jun 2026

Freshwater Harmful Algal Blooms (Habs) Public Health Message Efficacy Evaluation, Alexandra Benitez Gonzalez, Heather A. Triezenberg, Diane Doberneck, Abigail Bennett, Mark Rey

Journal of Contemporary Water Research and Education

Harmful algal blooms (HABs) can present health risks to humans, animals, or ecosystems. Communicating with the public about HABs risks can be challenging because symptoms vary in type and severity across different individuals. However, people with underlying health conditions are often particularly vulnerable to exposure, and they may experience negative health outcomes if they lack awareness of the risks that HABs pose. Literature on risk communication suggests that the way messages are framed influences the impact on risk perception and behavioral intentions. To provide insight into how agencies and practitioners can more effectively communicate health risks from HABs, we designed …


Dances With Birds, Richard F. Roadcap Dds Jun 2026

Dances With Birds, Richard F. Roadcap Dds

Virginia Dental Journal

No abstract provided.


Ooottafagvah = ???, Matthew Storm Dds Jun 2026

Ooottafagvah = ???, Matthew Storm Dds

Virginia Dental Journal

No abstract provided.


Ion Channels As Targets For Parasiticides: A Brief Review Of Past, Present, And Future Directions, Josette V. Ricker, Mallory Mendenhall Jun 2026

Ion Channels As Targets For Parasiticides: A Brief Review Of Past, Present, And Future Directions, Josette V. Ricker, Mallory Mendenhall

Georgia Journal of Science

Scientists and healthcare providers have tried for decades to find parasite treatments that balance patient safety with efficacy in eliminating the pathogen. One approach is to target specifically the parasite’s important bodily functions while sparing the host. This brief review examines the historically significant antiparasitics - pyrethrins, picrotoxin, piperazine, and avermectins – all which specifically target parasite ion channels. We discuss the history of their discovery and use, which subsequently led to the development of new generations of parasiticides, and continues to inspire the search for safe and effective treatments.


Visionarium, June 2026, Full Issue Jun 2026

Visionarium, June 2026, Full Issue

International Journal of Emerging and Disruptive Innovation in Education : VISIONARIUM

No abstract provided.


Differential Effects Of Amiloride And Benzamil On Salt Taste Physiology And Behavior: The Case For Phasic Responses In The Generation Of Sodium Appetite, Amyra M. Issa Jun 2026

Differential Effects Of Amiloride And Benzamil On Salt Taste Physiology And Behavior: The Case For Phasic Responses In The Generation Of Sodium Appetite, Amyra M. Issa

McNair Scholars Research Journal

The current experiment aims to investigate the relationship between the early phasic portion of salt taste transduction and sodium appetite. Prior research has identified two salt transduction pathways: a sodium-selective pathway, which is inhibited by amiloride or benzamil, and a non-selective pathway, which is insensitive to these blockers (Breslin & Spector, 2008). When presented with sodium solutions, sodium-depleted mice exhibit a behavior termed the “sodium appetite,” which results in voracious sodium consumption. The prevailing theory is that this behavior depends on neural activity of sodium-selective neurons (Breza & Contreras, 2012; Roitman & Bernstein, 1999). While previous studies have demonstrated that …


High Densities Of Large Herbivores Rapidly Disrupt Ecosystem Integrity, Jennifer A Krumins Jun 2026

High Densities Of Large Herbivores Rapidly Disrupt Ecosystem Integrity, Jennifer A Krumins

Department of Biology Faculty Scholarship and Creative Works

Human-induced high densities of large wild herbivores may pose a threat to natural ecosystems, modifying biodiversity and ecosystem functioning. Although the negative impacts on individual taxa and processes are well documented, a comprehensive understanding of how ecosystem integrity responds to high herbivore densities remains limited. This study addresses this gap through an extensive herbivore-density manipulation experiment conducted in two Mediterranean woodlands. We established two scenarios of high red deer (Cervus elaphus) density, representative of some protected areas (similar to 30 individuals.km(2)) and intensively managed hunting estates (similar to 90 individuals.km(2)). We monitored 38 metrics encompassing a broad spectrum of biodiversity …


Learning Trajectories Of Online Batch Selection Methods, Luke Green Jun 2026

Learning Trajectories Of Online Batch Selection Methods, Luke Green

Theses and Dissertations

Modern deep neural networks achieve strong performance on large-scale datasets, but often require substantial training time. Online batch selection methods seek to reduce this cost by updating models on informative subsets of each batch rather than on all available examples. Recently introduced methods leverage teacher models and report substantial speedups, particularly in noisy-label settings. However, comparisons are often based on the number of epochs required to reach a target test accuracy, a coarse metric that is sensitive to implementation details and may obscure important differences in learning dynamics. In this thesis, we implement several online batch selection methods in a …


Biologists Study Ways To Increase Food Production For Growing World, Clara Turnage Jun 2026

Biologists Study Ways To Increase Food Production For Growing World, Clara Turnage

University of Mississippi News

OXFORD, Miss. – With the world population expected to approach 10 billion by 2050, scientists are searching for ways to feed that many people with fewer resources. A new review outlines scientific advances that could help make food production more sustainable and resilient.


Microglial Swell1 Deficiency Drives Male-Specific Seizure Vulnerability But Paradoxical Neuroprotection Through Impaired Phagocytosis, Abhijeet S Barath, Aastha Dheer, Laura Montier, Mekenzie M Peshoff, Emily Dale, Flavia Goche, Thanh Thanh Le Nguyen, Mastura Akter, Fangfang Qi, Dimitrios Kleidonas, Lauren Harris, Sarah A Jewanee, Anthony D Umpierre, Dale B Bosco, Koichiro Haruwaka, Rajan Sah, Long-Jun Wu, Rongzhuo Hua, Tejaswani Datla Jun 2026

Microglial Swell1 Deficiency Drives Male-Specific Seizure Vulnerability But Paradoxical Neuroprotection Through Impaired Phagocytosis, Abhijeet S Barath, Aastha Dheer, Laura Montier, Mekenzie M Peshoff, Emily Dale, Flavia Goche, Thanh Thanh Le Nguyen, Mastura Akter, Fangfang Qi, Dimitrios Kleidonas, Lauren Harris, Sarah A Jewanee, Anthony D Umpierre, Dale B Bosco, Koichiro Haruwaka, Rajan Sah, Long-Jun Wu, Rongzhuo Hua, Tejaswani Datla

The Brown Foundation: Institute of Molecular Medicine

The discovery of genes encoding the volume-regulated anion channel (VRAC) has enabled detailed exploration of its cell type-specific roles in the brain. LRRC8A (SWELL1) is the essential VRAC subunit. We observed seizure-induced, subunit-specific changes in microglial VRAC expression and investigated its function using conditional KO (cKO) of LRRC8A in microglia. SWELL1 cKO mice exhibited a male-specific increase in kainate-induced seizure severity, yet showed paradoxical neuroprotection against seizure-associated neuronal loss. Mechanistically, SWELL1 deletion led to a cell-autonomous reduction in microglial density and decreased release of VRAC-permeable neuroactive metabolites, including taurine, GABA, and glutamate in culture. Additionally, impaired phagocytic kinetics and reduced …


Bovine Tuberculosis In The Middle East And North Africa: A Systematic Review And Meta-Analysis On Prevalence And Mycobacterium Bovis Clonal Complexes, Tsegaye Shamebo, Aboma Zewude, Temesgen Mohammed, Nabeeha Abdelgaleel Hassan, Mohammed Saleh Albreiki, Yassir Mohammed Eltahir, Atef Oreiby, Robert Barigye, Markos Tibbo, Ali Artaman, Gobena Ameni Jun 2026

Bovine Tuberculosis In The Middle East And North Africa: A Systematic Review And Meta-Analysis On Prevalence And Mycobacterium Bovis Clonal Complexes, Tsegaye Shamebo, Aboma Zewude, Temesgen Mohammed, Nabeeha Abdelgaleel Hassan, Mohammed Saleh Albreiki, Yassir Mohammed Eltahir, Atef Oreiby, Robert Barigye, Markos Tibbo, Ali Artaman, Gobena Ameni

All Works

Introduction – Bovine tuberculosis (bTB) is endemic in the Middle East and North Africa (MENA) region causing major threat to dairy production and milk consumers. This paper presents a comprehensive systematic review and meta-analysis of bTB prevalence and Mycobacterium bovis clonal complexes in the MENA region based on studies published between 2000 and 2025. Methods – A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, Embase, and relevant regional databases. Thirty-eight studies met the criteria and included in the meta-analysis. Random-effects meta-analysis was used to estimate pooled prevalence. Additional analyses were done on sensitivity, meta-regression, and publication …


Comparative Study Of Green Synthesis To Prepare Tio2 Nanoparticles From Plant Shard Leaves Extract By Using Microwave Irradiation And Microjet Plasma, Zainab Fakhri Merzah, Zainab J Shanan, Tayser Sumer Gaaz Jun 2026

Comparative Study Of Green Synthesis To Prepare Tio2 Nanoparticles From Plant Shard Leaves Extract By Using Microwave Irradiation And Microjet Plasma, Zainab Fakhri Merzah, Zainab J Shanan, Tayser Sumer Gaaz

Baghdad Science Journal

Plant extracts have been widely investigated as a safer alternative for the green synthesis of metal oxide nanoparticles. This study presents a green synthesis approach using shard leaf extract assisted by microwave irradiation and microjet plasma for the preparation of titanium dioxide nanoparticles (TiO2 NPs). The synthesized nanoparticles were characterized using Field Emission Scanning Electron Microscopy (FESEM), X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV–Vis), Fourier Transform Infrared Spectroscopy (FTIR), and zeta potential (ZP) analysis. XRD results confirmed the formation of the anatase phase of TiO2 without detectable brookite or rutile peaks, indicating high phase purity. The crystal structure was …


Synthesis And Characterization Of Zinc Oxide (Zno) Nanoparticles: From Chemical To Green Synthesis, Kawa S. Sulaiman, Ayoub S. Karim Jun 2026

Synthesis And Characterization Of Zinc Oxide (Zno) Nanoparticles: From Chemical To Green Synthesis, Kawa S. Sulaiman, Ayoub S. Karim

Baghdad Science Journal

The present research focuses on the synthesis and comparative analysis of zinc oxide nanoparticles (ZnO NPs) produced through two distinct methodologies: a traditional sol-gel procedure and a sustainable green synthesis route. The green synthesis approach utilized Laurus Nobilis leaf extract as a natural reducing and stabilizing agent, offering an eco-friendly alternative to conventional chemical synthesis. To evaluate the structural, optical, and morphological properties of the resulting nanoparticles, both sets of samples were characterized using UV-Vis spectroscopy, XRD, energy-dispersive X-ray spectroscopy (EDX), FTIR, and Field Emission Scanning Electron Microscopy (FESEM). The XRD patterns confirmed the successful formation of a hexagonal wurtzite …


Digraph And Graph Of Regular Rings With Some Properties, Shahla Moayad Kaleel, Haitham Nashwan Mohammed, Ahmad Mohammed Alghamdi, Ahmed Mohammed Ali, Eman Sultan Almotairi Jun 2026

Digraph And Graph Of Regular Rings With Some Properties, Shahla Moayad Kaleel, Haitham Nashwan Mohammed, Ahmad Mohammed Alghamdi, Ahmed Mohammed Ali, Eman Sultan Almotairi

Baghdad Science Journal

During this century, a new research trend has emerged wherein algebraic concepts are combined with graph theory, such as zero divisors, clean rings, ideals, and regular rings. Continuing this trajectory, the regular ring graph has been studied in two forms: the undirected graph and the directed graph. The vertex set consists of all regular elements in the ring ℜ, denoted by ℜ(ℜ), where the undirected graph is denoted by Γ(ℜ(ℜ)) and the directed graph by Ψ(ℜ(ℜ)). This study focuses on the rings Zn, where n = q, q², or 2q, and q is a prime number. In …


Modeling And Performance Analysis Of Two-Dimensional Vcsel Using Finite Element Simulation, Rand Mahdi Khudair, Shaimaa S. Mahdi Jun 2026

Modeling And Performance Analysis Of Two-Dimensional Vcsel Using Finite Element Simulation, Rand Mahdi Khudair, Shaimaa S. Mahdi

Baghdad Science Journal

Vertical cavity surface emission lasers (VCSELs) are considered to be an integral component of short-range optical communication. Compact structure, low threshold current, and high modulation capability are the reasons why these communication systems are used. efficiency. This study presents a two-dimensional numerical simulation of a VCSEL structure at a wavelength of 850 nm using the finite element method (FEM) via Laser MOD software to investigate the effect of using two different quantum well materials (QW) GaAs, and AlGaAs on the optical performance of the device. All of the above were done within the same cavity and DBR structure to provide …


Effect Of Cupc Film Thickness Prepared By Thermal Evaporation On The Performance Of An Optical Detector, Zainab Hazim Abdul Raheem, Sameer Khudhur Yaseen, Mohammed K. Khalaf Jun 2026

Effect Of Cupc Film Thickness Prepared By Thermal Evaporation On The Performance Of An Optical Detector, Zainab Hazim Abdul Raheem, Sameer Khudhur Yaseen, Mohammed K. Khalaf

Baghdad Science Journal

Copper phthalocyanine (CuPc) is a semiconductor that is chemically very stable, highly optically absorbing of visible light, and possesses good charge transport properties, so it is a promising material for optoelectronic devices and photodetectors. In this study, CuPc thin films with thickness range 146.4–632.4 nm were grown on ultrasonically cleaned glass substrates by thermal evaporation at a pressure of 2.2 × 10-5 torr. Structure, morphology, and optical properties were analyzed to study the effect of thickness on photoconductive response. X-ray diffraction analysis revealed that the films were polycrystalline monoclinic with preferred (312) orientation. AFM images showed increase in grain …


Studying The Physisorption And Reaction Between In9Sno15 Pyramid Nanocluster With Water Molecule Via Transition State Theory, Nisreen A. Fejer, Asmaa H. Mohammed, Mohammed T. Hussein Jun 2026

Studying The Physisorption And Reaction Between In9Sno15 Pyramid Nanocluster With Water Molecule Via Transition State Theory, Nisreen A. Fejer, Asmaa H. Mohammed, Mohammed T. Hussein

Baghdad Science Journal

This study investigates two binary semiconductors, Sn10O15 and In10O15, to form a ternary In9SnO15, a potential indium tin oxide (ITO) pyramid nanocluster for a humidity sensor, using density functional theory and transition-state theory. B3LYP hybrid functional was applied with the 6-311G** basis set for light elements (H, O) and (SDD) basis set for heavy elements (In, Sn). Steady-state geometrical structures were obtained using a complementary program, Gaussian View 05, and the corresponding electronic properties. HOMO and LUMO were calculated via the Gaussian 09W software program …


Coefficient Bounds For A New Subclass Of Meromorphic Multivalent Functions With Higher Derivatives Obtained From Bessel Function, Ali Musaddak Delphi Jun 2026

Coefficient Bounds For A New Subclass Of Meromorphic Multivalent Functions With Higher Derivatives Obtained From Bessel Function, Ali Musaddak Delphi

Baghdad Science Journal

The goal of this paper is to introduce a new subclass of meromorphic multivalent functions with higher derivatives inside a punctured open unit disk U*, by generalizing the Bessel function. The method used to derive the new findings on this topic is stated in section two of this paper. The product theorem between two functions and neighborhood properties was obtained using the recently discovered coefficient bounds for the new subclass. In addition, this paper attempted to address an important research gap in the subject of geometric function theory, which is the computational tools for coefficient bounds through the use …


Quasi-Mixing C0-Semigroups And Their Relations With Recurrent C0-Semigroups, Mansooreh Moosapoor, Otmane Benchiheb Jun 2026

Quasi-Mixing C0-Semigroups And Their Relations With Recurrent C0-Semigroups, Mansooreh Moosapoor, Otmane Benchiheb

Baghdad Science Journal

This article presents and investigates the concept of the quasi-mixing C0-semigroups. It is proved that the quasi-mixing of an invertible C0-semigroup is equivalent to the quasi-mixing of its inverse. The quasi-mixing vectors are defined and they are used to prove a sufficient condition for the quasi-mixing. It is established that the quasi-mixing of a C0-semigroup is equivalent to the quasi-mixing of any of its discretizations. The quasi-mixing of a C0-semigroup ( Tt )t ≥ 0, as it is demonstrated by this study, implies the quasi-mixing for each operator T …


Evaluation Of Home Loan Candidates Using Energy And Laplacian Energy In Hesitancy Fuzzy Zagreb Matrices, A. Abinaya, G. Deepa Jun 2026

Evaluation Of Home Loan Candidates Using Energy And Laplacian Energy In Hesitancy Fuzzy Zagreb Matrices, A. Abinaya, G. Deepa

Baghdad Science Journal

A hesitancy fuzzy graph is a type of generalized fuzzy graphs that reflects reluctance or uncertainty in interactions by assigning a variety of potential membership values rather than a single value to each vertex and edge. It offers an adaptable framework for simulating intricate systems with ambiguous, reluctant, or imperfect input. Topological measurements that capture and characterize a graph's structural features are called Zagreb indices, and they are obtained from vertex degrees. Although Zagreb indices and graph energies have been studied for intuitionistic fuzzy graphs, fuzzy graphs, and classical graphs, no work has been done to apply these ideas to …


Approximation In S-Normed Orlicz Spaces, Zainab Abdulmunim Sharba, Hawraa Abbas Almurieb, Samah Alhashemi Jun 2026

Approximation In S-Normed Orlicz Spaces, Zainab Abdulmunim Sharba, Hawraa Abbas Almurieb, Samah Alhashemi

Baghdad Science Journal

Orlicz spaces generalize conventional Lebesgue spaces, providing a more flexible framework for analyzing functions. They are essential to functional analysis and related fields, particularly in approximation theory. This paper defines an Orlicz normed space equipped with an S-norm, where S is an outer function that satisfies certain conditions. Introducing norms via the outer function S is a general method that encompasses many cases of norms in Orlicz spaces. The relationship between S-norm and other norms on Orlicz spaces is established through several equivalences. Moreover, moduli of smoothness are of great interest in approximation theory, as they provide criteria …


Numerical Study Of The Effect Of Embedded Radiation On Fluid Flow And Heat Transfer In A Porous Medium, Shaymaa M. Younus, Iman Al-Obaidi Jun 2026

Numerical Study Of The Effect Of Embedded Radiation On Fluid Flow And Heat Transfer In A Porous Medium, Shaymaa M. Younus, Iman Al-Obaidi

Baghdad Science Journal

This takes a look at ambitions to investigate the two-dimensional flow pattern of fluids in a conductive medium constrained between two parallel horizontal plates under the influence of embedded radiation. The mathematical model is based entirely on the flow equations, including the continuity, momentum, energy, and diffusion equations. The machine is solved numerically the usage of the specific finite difference approach (ADE) to investigate the conduct of drift, temperature, and mass transfer below radiative outcomes. The study specializes in the impact of key dimensionless parameters, including the Reynolds number, Darcy number, Grashof number, Péclet number, radiation parameter, mixed radiation, and …


The Courier, Summer 2026, Tennessee. Historical Commission. Jun 2026

The Courier, Summer 2026, Tennessee. Historical Commission.

Tennessee Historical Commission

No abstract provided.


Bottlebrush Polymer Conjugates For Enhanced Antisense Oligonucleotide Therapy In Myotonic Dystrophy Type 1, Yao Li, Gyu Seong Heo, Yongjian Liu, Et Al. Jun 2026

Bottlebrush Polymer Conjugates For Enhanced Antisense Oligonucleotide Therapy In Myotonic Dystrophy Type 1, Yao Li, Gyu Seong Heo, Yongjian Liu, Et Al.

2020-Current year OA Pubs

Oligonucleotides are a promising class of genetic medicine for myotonic dystrophy type 1 (DM1), the most common adult-onset muscular dystrophy. However, poor muscle distribution of nucleic acid drugs following systemic administration has hindered drug development, and no curative treatment currently exists. DM1 pathology requires drug localization to the nucleus, where pathogenic mutant RNA is sequestered, posing additional challenges after cellular internalization regarding endosomal escape and nuclear uptake. Here, we show that a locked nucleic acid oligonucleotide targeting mutant CUG repeat RNA tracts, conjugated to a bottlebrush polymer, exhibits improved muscle distribution and potent correction of DM1-associated splicing dysregulation in a …


Quantitative Genetic Analysis Of Baboon Facial Variation Challenges A Classic Papionin Trait, A. Thiebaut, C. C. Roseman, Michael Mahaney, Leslea J. Hlusko Jun 2026

Quantitative Genetic Analysis Of Baboon Facial Variation Challenges A Classic Papionin Trait, A. Thiebaut, C. C. Roseman, Michael Mahaney, Leslea J. Hlusko

Human Genetics Publications

The Linnaean family of monkeys that includes baboons, macaques, and mandrills (among others) is notably characterized by large, extended muzzles that vary in lateral nasal dorsum profile. In paleontological studies, this variation is referred to as the anteorbital drop (AOD). Here, we first devise a method to quantify this phylogenetic character. We then employ quantitative genetic analyses using a MCMCglmm model of facial variation in a captive, pedigreed baboon colony (n = 934), including admixed individuals derived from at least two Papio species, from the Southwest National Primate Research Center to assess the quantitative variation of the AOD, its …


Characterizing The Relationships Between Hydrology, Soil Biogeochemistry, And Green Ash Canopy Structure In Emerald Ash Borer-Affected Wetlands, Eva Switala Jun 2026

Characterizing The Relationships Between Hydrology, Soil Biogeochemistry, And Green Ash Canopy Structure In Emerald Ash Borer-Affected Wetlands, Eva Switala

Theses

The invasion of the emerald ash borer (EAB; Agrilus planipennis) has caused mass mortality of native ash trees (Fraxinus spp.), devastating forested wetlands in the northeastern United States. Fifteen years post-introduction, the long-term ecological shifts and "new normals" of these ecosystems remain poorly understood. This project characterized patterns in EAB-affected forested wetlands by evaluating soil characteristics, biogeochemical cycling, hydrology, and green ash canopy across 12 sites with varying initial ash presence. Results revealed a clear separation between biogeochemically active and less active sites. Hydrologic differences emerged as a key driver of biogeochemical cycling, with higher soil moisture significantly increasing rates …