Digital Commons Network^™

Donor-Derived Cell-Free Dna As A Prognostic Biomarker After Heart Transplantation: The Define-Ht Study, Palak Shah, Paul J. Kim, Kelly H. Schlendorf, David A. Baran, Monica M. Colvin, Adam D. Devore, Howard Eisen, Kambiz Ghafourian, Michael M. Givertz, Eileen Hsich, Jaime L. W. Kennedy, Evan P. Kransdorf, Jose N. Nativi-Nicolau, Jignesh Patel, Eleni Tseliou, Omar Wever-Pinzon, Andrew Doud, Michelle S. Bloom, Sandra A. Carey, Navchetan Kaur, D Giovanni Biagini, Kyle E. Marshall, Michael Olympios, Mandeep R. Mehra, Josef Stehlik

Department of Medicine Faculty Papers

BACKGROUND: Measurement of donor-derived cell-free DNA fraction (dd-cfDNA%) and donor quantity score (DQS) is a noninvasive biomarker of acute rejection in heart transplantation (HT). Its prognostic value beyond histopathology remains uncertain.

OBJECTIVES: This study sought to evaluate associations between donor-derived cell-free DNA (dd-cfDNA) and clinically meaningful outcomes using a composite endpoint of treated rejection, graft dysfunction, retransplantation, or death within 1 year post-HT.

METHODS: The DEFINE-HT (Development of Noninvasive Cell-free DNA to Supplant Invasive Biopsy in Heart Transplantation) was a prospective, observational study following adult HT recipients at 10 U.S. centers for 1-year post-HT; blood was collected for dd-cfDNA testing …

Sharing The Voices Of Latine Students: Their Experiences Of Community, Belonging And Joy In A Suburban Public High School, Ashley Acosta-Meyers

School of Education and Leadership Student Capstone Theses and Dissertations

This qualitative phenological and ethnographic study explored how seven Latine high school students in a suburban public high school defined and experienced community, belonging, and joy, asking what school spaces, experiences, and practices build or diminish these three concepts. Data was collected through four interview sessions per participant, reflective journaling, and three culturally and linguistically responsive walkthrough observations, and were analyzed through layered linguistic, narrative, and thematic coding. Findings showed that belonging and joy were tied to specific spaces rather than felt evenly across the school day. Institutional fairness shaped belonging as much as any relationship. Latine identity was contested, …

Valorization Of Rice Bran For Functional Film Fabrication Using Cold Plasma For Food Packaging And Biomedical Applications, Saydul Md Safwa

Graduate Theses and Dissertations

Abstract Over the past few years, conventional plastic packaging materials have become increasingly concerned with their environmental impact. Therefore, the demand for bioplastics has been increasing significantly over the years. Rice milling, a process that modifies paddy rice into edible rice, generates by-products such as rice bran. Rice bran has cellulose, hemicellulose, lignin, and protein, which makes it a potential material for bioplastic fabrication. However, like most biodegradable films, rice bran films fall short when it comes to practical packaging applications. They often lack the strength, flexibility, moisture resistance, and barrier performance needed to compete with synthetic plastics. Most importantly, …

Seasonality Of Bovine Respiratory Disease Incidence, Nasal Temperatures, And The Nasal Microbiome In Receiving Beef Cattle: Understanding The Risk Of The Bovine Respiratory Disease Complex, Robin Ashley Cheek

Graduate Theses and Dissertations

Bovine respiratory disease (BRD) has persistently been the leading cause of morbidity of beef cattle in the United States. Season has been directly associated with respiratory disease incidence and is likely a proxy for weather conditions, which vary by geographical location. The nose is one of the first points of contact between the outside environment and inside the body. The nasal microbiome and its relationship with BRD have been heavily studied within beef cattle, but there are not yet any studies to determine if the environment within the nasal cavity has a role to play in this mechanism. This dissertation …

Investigating Culicoides Diversity, Distribution, And Behavior In Arkansas, Cassandra Steele

Graduate Theses and Dissertations

Culicoides biting midges (Diptera: Ceratopogonidae) are globally important vectors of pathogens affecting livestock and wildlife. In the United States (US), transmission of bluetongue virus (BTV), epizootic hemorrhagic disease virus (EHDV), and vesicular stomatitis virus (VSV) results in economic losses and periodic mortality events of wild and domestic ruminants. Culicoides sonorensis is the confirmed vector of BTV and EHDV in the western regions of the US, however this species is uncommon throughout much of the eastern and southeastern US, where hemorrhagic diseases remain endemic. There are likely other putative vector species responsible for pathogen transmission. This research investigated Culicoides diversity, distribution, …

Beyond Semantic Matching: Integrating Graph Structures, Boolean Logic, And Interactive Aggregation In Modern Retrieval, Quan Mai

Graduate Theses and Dissertations

Modern Natural Language Processing (NLP) and Information Retrieval (IR) systems have achieved remarkable success in semantic understanding; however, they continue to struggle with complex logical reasoning, structural interactions, and dynamic aggregation. This dissertation presents a comprehensive framework to enhance the structural, logical, and interactive capabilities of language models and retrieval systems across four progressive studies. First, we address the challenge of modeling dynamic conversational logic in online debates. We introduce a Sequence Graph Network (SGN) that captures the temporal and interactive exchange of ideas—such as counterarguments and reinforcements—by updating node features sequentially through a novel Sequence Graph Attention (SGA) layer. …

Effects Of Soil Contamination On The Efficacy Of Antimicrobial Washes For Contaminated In-Shell Pecans, Erin Ramsay

Graduate Theses and Dissertations

A study was done to evaluate the survival of Shiga toxin-producing Escherichia coli (STEC) on directly and soil-inoculated in-shell pecans over a 28-day period, determine STEC reductions after treatment with individual and sequential antimicrobial washes on direct and soil-inoculated in-shell pecans, and determine the cross-contamination potential of the spent pecan washes after a treatment. Pecans were directly and soil-inoculated with an STEC cocktail (O157:H7, O157:NM, O121, and O26). Direct inoculation was achieved by spraying the STEC cocktail on the pecans and homogenizing by hand for 2 min. For the soil-inoculation method, autoclaved pecan tree orchard soil was sprayed with the …

Soil Moisture Regime Effects On Greenhouse Gas Emissions In A Native Tallgrass Prairie In The Ozark Highlands, Thomas William Dockery

Graduate Theses and Dissertations

The Ozark Highlands is an ecoregion in the mid-southern portion of the United States that is characterized by a mosaic of tallgrass prairies, oak (Quercus spp.) savannas, and oak-hickory (Carya spp.) forests, which represents a unique biophysical transition zone between the relatively dry grasslands of the west and the humid forests of the southeast. Quantifying greenhouse gas (GHG) emissions, namely carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O), from natural, undisturbed ecosystems is critical to understanding atmospheric warming and climate-change implications. The objective of this study was to simultaneously evaluate CO2, CH4, and N2O emissions in an aquic and …

Evaluation Of Metabolizable Energy And Phosphorus Availability In Conventional And Fractionated Dry-Grind Corn Co-Products For Poultry, Luke Parisi

Graduate Theses and Dissertations

The purpose of this research was to determine the availability of energy and phosphorous (P) in dry-grind corn co-products in chickens was assessed. In the first objective, the determination of energy availability, both a precision-fed rooster assay and an ad libitum fed broiler chicken assay were used in order to elucidate energy availability in corn co-products. There were 8 samples of corn fermented protein (CFP) and 2 samples of conventional distillers dried grains with solubles (CDDGS) evaluated for metabolizable energy (ME). The CFP contained a mean CP and crude fat of 55 and 3.7% (DM basis), respectively, compared with 30 …

Organic-Complexed Or Inorganic Trace Mineral Tub Supplementation: Impacts On Productivity And Reproductive Outcomes In Beef Cows And Heifers, Jacy Riddle

Graduate Theses and Dissertations

The objective of these experiments was to investigate the effects of organic-complexed or inorganic trace minerals (copper, cobalt, manganese, and zinc) on cow reproductive performance, suckling calf growth, as well as heifer development and reproductive outcomes utilizing free-choice tub supplementation. In lactating cows, treatments consisted of molasses-based tub supplementation containing either complexed or inorganic trace minerals, with an additional pre-breeding drench administered only to cows receiving complexed minerals. The drench contained complexed or organic copper, cobalt, manganese, and zinc. Supplementation began approximately 6 weeks prior to fixed-timed artificial insemination (FTAI) and continued until bull removal (d 105). In weaned replacement …

Evaluating Variety- And Market-Class-Specific Effects Of Dietary Pulses On Human Health, Jiayu Tang

Department of Food Science and Technology: Dissertations, Theses, and Student Research

While pulses are globally recognized for their high levels of dietary fibers, protein, and polyphenols, research often focuses on characterizing the physiological effects of a single variety. This approach overlooks the substantial genetic and compositional diversity that exists across pulse varieties and individual market classes, which can differ extensively in nutrient content and structure. These compositional differences have the potential to produce distinct physiological and microbial responses in humans, yet variety- and market-class-specific effects remain poorly characterized.

This thesis uses two complementary research methodologies to investigate the health-relevant effects of different pulse varieties and market classes, providing foundational knowledge to …

Evaluating Relationships Between Immunometabolism And Excess Adiposity Using Anthropometric And Body Composition Measurements, Corina Grimaldo

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Metabolic dysfunction is a key contributor to the development of chronic disease and is associated with excessive adiposity. Though body mass index (BMI) is a common screening tool used to identify possible metabolic dysfunction, it does not consider fat distribution. Other tools are needed to assess body composition and determine fat distribution. In recent studies, it has been suggested that alterations in metabolic processes may occur prior to a clinical diagnosis, and the combination of body composition and blood-based markers can help identify those early changes. The overall objective of this study is to identify low-cost indicators of metabolic dysregulation …

Wooster Magazine: Summer 2026, Caitlin Paynich Stanowick, The College Of Wooster

Wooster Magazine: 2021-2030

 The summer 2026 issue of Wooster magazine explores the role of mentorship in shaping inquiry, confidence, and lifelong learning at The College of Wooster. Features examine how personalized guidance supports student research through Independent Study, including projects by psychology and music, classical studies, physics, and computer science and neuroscience students that explored music cognition, ancient texts, consciousness, and distant galaxies. Additional featured stories highlight a faculty professional learning community focused on strengthening mentoring practices across campus and alumni Amber Rice ’01, Austin Russell ’19, Marcel El Kouri ’21, and Emily Beuter ’20, who carry forward the lessons and values of …

Desert Desires And The War On Terror: Pre- And Post-9/11 Sheikh Romances, Leena Altamimi

Book Publishing Final Research Papers

The existence of sheikh romances as a subgenre has prevailed for well over a century in Western literature. Therefore, would one be able to discern whether the book cover imagery as well as the textual content showcases any tangible differences pre and post 9/11, and America’s “war on terror” campaign? A total of five books are observed: The Sheik by E.M. Hull published in 1919, Sarah Holland’s Desert Destiny published in 1991, Loreth Anne White’s The Sheik Who Loved Me and Penny Jordan’s Possessed by the Sheikh (both published in 2005), and lastly Crowned for the Sheikh’s Baby by Sharon …

Llu Dentistry 2026 Summer Edition, Loma Linda University School Of Dentistry

Articulator (Dentistry)

In this issue:

4 | Dean's Message
9 | LLUSD Homecoming 2026: A Celebration of Legacy & Future Growth
19 | Celebrating 48 Years A Tribute to Kathleen Moore Rychman
21 | A Natural Calling: Dr. Yawen Peng, Program Director
22 | A Legacy of Excellence R. David Rynearson, DDS'71, MS'87 honored with the O.B. Vaughan Special Recognition Award
25 | CDA Presents Anaheim
32 | Dental Hygiene Pinning Ceremony
36 | Called to Serve Baccalaureate and the Class of 2026
40 | Commencement
45 | President's Award
46 | Prince Award
54 | Dental Hygiene Student Awards
56 | …

Visual Structure, Cultural Memory, And Viewership In Early Medieval Irish High Crosses, Trinity Smith

Theses

This thesis examines how Irish high crosses functioned as structured visual forms through which religious authority and cultural memory were communicated within early medieval Ireland. Previous scholarship has emphasized the theological coherence of these monuments, often assuming a single idealized viewer. This study reconsiders Irish high crosses through the concept of multiple viewership by examining how different audiences may have encountered and understood these monuments. Using comparative visual and contextual analysis, this study examines four case studies: the Cross of the Scriptures at Clonmacnoise, Muiredach’s Cross at Monasterboice, the High Cross of Durrow, and the Market Cross at Kells. This …

From Grid To Freedom: A Comparative Analysis Of Canva’S Guardrails And Adobe Illustrator’S Design Flexibility, Caroline Wilmes

Theses

This project focuses on graphic design software becoming increasingly accessible and questions emerging regarding the role of professional designers and the value of industry-standard design tools. This project examines the differences between Canva, a widely used template-driven design platform, and Adobe Illustrator, a professional vector-based design application. Through a hands-on, project-based research approach, the same brand identity was developed in both programs, including a style guide, business card, website homepage mock-up, and tri-fold. The comparison focused on workflow efficiency, creative freedom, typography, color management, scalability, and production readiness.

Findings revealed that Canva excels in accessibility, speed, and ease of use …

Quiet Relief: Voice In Migraine Packaging, Nicole Allgeyer

Theses

This paper explores typography as a form of nonverbal communication in pharmaceutical branding for a fictional medication called Neura by investigating how font choice, visual hierarchy, spacing, and color function as communicative tools to its viewers. This paper combines the studies of semiotics and branding to create a brand that evokes trust, calm, and clarity through a visual branding system. This study investigates visual signifiers (semiotics) such as color and type through visual analysis and implements the findings into the brand. By researching branding, I was able to create a brand that has a focused demographic and image. In creating …

The Significance Of Abstract Art In Self-Expression: A Study Developed By Analyzing Kandinsky's Black Lines And Producing Visual Juxtapositions, Keturah K. Bowles

Theses

This paper will contemplate how the creation of abstract art, a creative style born from the Avant-Garde movement of the 20th century by artists such as Wassily Kandinsky, was imperative in the pursuit of artistic freedom. Additionally, it will seek to prove that abstraction is one of the unparalleled genres to utilize for self-expression in comparison to genres that uphold traditional art techniques, such as realism. This theory is further emphasized when considering abstract art in juxtaposition to the art standards maintained by the academy. Moreover, the research conducted to support the proposed theory falls into various categories, such as …

Web Of Sisterhood: Somehow Connected, Catherine Scott

Theses

This thesis project is about the connection between female community (sisterhood) and art-making practices. This connection is explored through qualitative research, including research in art history, feminism, community interviews, and personal experience. The connection between sisterhood and art-making is expressed through the construction and development, as well as the visual elements, in the final project. Communication and collaboration with women in my community about the artwork and our connections as women shaped how the work would be constructed, as well as the imagery and colors used in the final piece.

Assessing Vertebrate Biodiversity In An Agricultural And Urban Impacted River Using Environmental Dna Metabarcoding, Surabhi Nair

AES Theses

Rivers are dynamic freshwater systems that can experience shifts in flood regime that are driven by anthropogenic activity and climate change. These changes may no longer support the native species in the ecosystem and can favor invasive generalist species. The Pajaro River supports a range of urban, agricultural, and natural habitats and is prone to seasonal flooding that can affect habitat conditions and biodiversity. Current vertebrate diversity in the Pajaro River is not well understood, although traditional surveys have documented both rare and invasive species. Environmental DNA, or eDNA, can help address gaps in traditional monitoring by detecting elusive or …

Proteogenomics Of Hypertrophic Cardiomyopathy Reveals Subtype-Specific Therapy, Ke Ma, Jie Yang, Hongchang Guo, Ping Li, Xiaowei Li, Zhujun Dong, Jing Zhang, Congcong Zhang, Pengli Yang, Chongpei Hua, Shuolin Zhu, Guoqing Li, Jianchao Zhang, Ningyu Ding, Jizheng Wang, Xin-Liang Ma, Zhuofeng Lin, Jianzeng Dong, Yang Li, Yulin Li

Department of Emergency Medicine Faculty Papers

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a heterogeneous disease with diverse prognosis. The underlying mechanisms remain unknown, resulting in limited risk stratification and therapeutic strategies. This study aimed to elucidate molecular subtypes of HCM through integrated proteogenomic analysis and explore subtype-specific therapeutic strategies.

METHODS: We conducted an integrated proteogenomic analysis of 132 patients with HCM using myocardial samples, incorporating whole-exome sequencing, RNA sequencing, and proteomics. Unsupervised clustering was used to identify HCM subtypes, which were validated in heart tissues and human induced pluripotent stem cell-derived cardiomyocytes from 2 independent HCM subsets. Subtype-specific signatures and pathways were explored, and their causal link …

Table Of Contents

Washington and Lee Law Review

No abstract provided.

Reimagining International Investment Law For The Age Of Minerals, Taylor Nchako

Washington and Lee Law Review

New technologies––from artificial intelligence (AI) and electric vehicles to medical devices and consumer electronics––demand an ever-increasing amount of minerals like lithium, cobalt, and copper. The United States requires these aptly named “critical” minerals to develop AI infrastructure, advance the clean energy transition, and remain economically competitive. As technology continues to advance at an astonishing pace, the U.S. has grown increasingly interested in securing critical minerals from sources in Africa. To obtain critical minerals, the U.S. must utilize investment treaties in its business dealings with African countries. At the same time, international investment law has garnered increased attention due to a …

Fur, Feathers, And Frameworks: The Federal Legal Landscape Of Animal Welfare In The United States And Switzerland, Michael Melch

Washington and Lee Law Review

The United States relies on a predominantly utilitarian, welfarist framework that regulates certain uses of animals while preserving their status as property. Switzerland embeds the concept of animal dignity in its constitutional and statutory law, formally recognizing animals as beings with intrinsic worth. This foundational divergence produces significant doctrinal and practical differences, including the breadth of species covered, the structure of legal obligations, and the normative goals of regulation.

This Note provides a comparative analysis of animal welfare laws in the United States and Switzerland, exploring their philosophical, legal, and practical dimensions. It examines the U.S.’s utilitarian approach, exemplified by …

Enhancing Virtual Reality Cockpit Procedure Training With Haptic Feedback, Christian K. Jaedicke

Doctoral Dissertations and Master's Theses

Pilot training is time-consuming and costly, and not all phases require full-flight simulators or actual aircraft. Virtual reality (VR) offers a potential means to reduce cost and duration while supporting practical cockpit procedure training. While prior research in the VR domain suggests that providing haptic feedback can support training of muscular control and increase perceived immersion, it remains unclear whether haptic feedback improves spatial cognition in an unfamiliar VR environment. This study examined whether haptic feedback and cockpit complexity affected response time and position error under limited-visibility, time-constrained conditions in a VR cockpit environment (i.e., a quasi-blindfold cockpit check).

Grounded …

Analyzing The Benefits Of Artificial Intelligence To Racially Inclusive Democracy, Spencer Overton

Utah Law Review

Over the past two decades—as the United States has grown more ethnically diverse—the U.S. Supreme Court has dismantled key voting rights protections, and state legislatures have erected a record number of voting restrictions. Largely oblivious to this growing gap in legal protections, several artificial intelligence (“AI”) optimists have claimed that AI can help usher in a more inclusive, participatory, and unbiased democracy. Such an outcome, however, is far from guaranteed. This Article is the first to comprehensively examine the extent to which AI—and the legal frameworks that regulate it—can advance racially inclusive democracy. It responds to the AI optimism literature …

Animal Science Research And Extension Report 2026 (Complete Report), Department Of Animal Science

Animal Science Research Report 2026

This is the 2026 Animal Science and Extension Report. This highlights the research being generated within the department over the previous year.

Fungal Diversity In Lespedeza Cuneata Roots, Gwendolyn Happ, Sophia Mcdade, Anthony Yannarell

MICRO-CCS student projects

Background

• Plants form a relationship with fungi that can be beneficial or harmful
• Fungi may grow on the plant surface, within plant tissues, or around roots
• Plants release compounds that invite fungi to their roots and chemicals  that can diminish unwanted fungi

Why Lespedeza cuneata? 

• Invasive that competes with native plants and damages biodiversity within plant and animal communities
• Alters soil microbiome
• Expansive seed bank and deep root system
• Understanding its microbiome can help in understanding invasive species success and ecology

Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer's Disease Risk Prediction In Multiethnic Cohorts, Meri Okorie, Caroline Jonson, Alexis Oddi, Patricia Castruita, Brian Fulton-Howard, Kristine Yaffe, Jennifer Yokoyama, Chinedu Momoh, Shea Andrews

Brain and Mind Institute

INTRODUCTION Genome-wide association studies (GWAS) have identified 80+ genetic loci associated with Alzheimer's disease (AD), enabling the development of polygenic risk scores (PRS). However, the predictive accuracy of PRS in diverse populations remains low. Here, we evaluated the predictive accuracy of single-, multi-, and cross-ancestry AD-PRS models across multi-ancestral populations.

METHODS We used AD GWAS summary statistics from European, African, Admixed American, and East Asian populations to construct AD-PRS for each target population. Model performance was assessed by estimating odds ratios, R2, and area under the curve.

RESULTS The cross-ancestry Bayesian PRS model demonstrated the highest predictive performance in non-European …