Digital Commons Network^™

Investigation Of A Global Mouse Methylome Atlas Reveals Subtype-Specific Copy Number Alterations In Pediatric Cancer Models., Melanie Schoof, Tuyu Zheng, Martin Sill, Roland Imle, Alessia Cais, Lea Altendorf, Alicia Fürst, Nina Hofmann, Kati Ernst, Dominik Vonficht, Kenneth Chun-Ho Chan, Tim Holland-Letz, Andreas Postlmayr, Ryo Shiraishi, Wanchen Wang, Alaide Morcavallo, Michael Spohn, Carolin Göbel, Judith Niesen, Levke-Sophie Peter, Franck Bourdeaut, Zhi-Yan Han, Yanxin Pei, Najiba Murad, Fredrik J. Swartling, Jessica Taylor, Monika Yadav, Garrett R. Gibson, Richard J. Gilbertson, Matthias Dottermusch, Rajanya Roy, Kornelius Kerl, Rainer Glass, Jiying Cheng, Martin A. Horstmann, Gerrit Wolters-Eisfeld, Haotian Zhao, Dominik Sturm, Viveka Nand Yadav, Louis Chesler, Simon Haas, William A. Weiss, Paul A. Northcott, Lena M. Kutscher, Ana Guerreiro Stucklin, Olivier Ayrault, Julia E. Neumann, Daisuke Kawauchi, David T W Jones, Kristian Pajtler, Ana Banito, Stefan M. Pfister, Ulrich Schüller, Marc Zuckermann

Manuscripts, Articles, Book Chapters and Other Papers

Copy number alterations (CNAs) are hallmarks of cancer, yet investigation of their oncogenic role has been hindered by technical limitations and missing model systems. Here we generated a genome-wide DNA methylation and CNA atlas of 106 genetic mouse models across 31 pediatric tumor types, including 18 new models for pediatric glioma. We demonstrated their epigenetic resemblance to human disease counterparts and identified entity-specific patterns of immune infiltration. We discovered that mouse tumors harbor highly recurrent CNA signatures that occur distinctly based on the tumor subgroup and driving oncogene and showed that these CNAs share syntenic regions with the matching human …

Efficacy Of Endophytic Fungi In The Management Of Spoladea Recurvalis (Lepidoptera: Crambidae) On Amaranth (Amaranthus Dubius), Druscilla Obonyo Nyamamba

All Master’s Theses

Amaranth is a Traditional African Vegetable (TAV) that in recent years has gained global popularity due to its exceptional nutritional, medicinal and economic attributes. However, its production is significantly limited by insect pest infestations, mainly lepidopteran defoliators. Spoladea recurvalis, commonly known as Hawaiian beet webworm has been reported as the major pest that feeds voraciously on the leaves leading to substantial yield losses of up to 100% under severe pest infestation. Chemical control remains a widely used method for the management of S. recurvalis. The use of fungal endophytes has emerged as a promising, sustainable and eco-friendly alternative to …

A Psychosocial And Psychometric Exploration Of Hikikomori In The Uk, Gregory Gorman

School of Psychology Theses

Hikikomori - originally identified in Japan as a severe form of social withdrawal - has evolved into a global phenomenon mirroring broader transformations in labour, technology, and identity. Once deemed a culture-bound syndrome, it is increasingly understood as a “society-bound” expression of psychosocial strain, existential unease, and retreat from normative life scripts. This thesis advances understanding of hikikomori by developing and validating psychometric tools, identifying subtypes of withdrawal, and situating the phenomenon within wider socio-cultural, digital, and philosophical frameworks.Empirical chapters detail the development of two novel tools: the Hikikomori Risk Inventory-13 (HRI-13) and the expanded Hikikomori Syndrome Behaviour Scale (HSBS). …

The Role Of The Amygdala In Huntington Disease-Associated Aggression, Luis Torres

Honors Undergraduate Theses

Huntington disease (HD) is a fatal neurodegenerative disorder caused by a trinucleotide CAG expansion in the huntingtin gene (HTT). HD is characterized by motor, cognitive, and psychiatric symptoms that significantly impact patient and caregiver quality of life. Psychiatric symptoms, including depression, anxiety, and irritability, are common manifestations of HD and can emerge years before the onset is clinically diagnosed. Aggression is a common and challenging psychiatric symptom in HD, often misunderstood and associated with caregiver stress, early institutionalization, and reduced quality of life. Despite its clinical impact, aggression in HD lacks effective, targeted treatment options. Similar to HD …

Developing A Serious Game-Based Platform To Support Programming Learning, Noven Indra Prasetya, Nia Saurina, Arief Ardiansyah

Journal of Educational Technology Development and Exchange (JETDE)

Programming learning, especially among informatics students, faces significant challenges related to understanding concepts and syntax, as well as low engagement in programming courses. To address these issues, this research developed DolananCoding, a serious game-based learning platform specifically designed for C++ programming learning. The platform integrates a live coding feature, enabling students to write code directly, along with a leaderboard to motivate them through healthy competition. The immersive concept in DolananCoding is designed to provide an interactive and enjoyable learning experience, aiming to enhance students’ engagement, motivation, and learning outcomes in C++ programming. This research aims to test the effectiveness of …

Coding, Machine Learning, And Game Engines In Initial Teacher Training, Sara Redondo-Duarte, José Manuel Sáez-López

Journal of Educational Technology Development and Exchange (JETDE)

This study evaluated the integration of coding, visual block programming, game engines, and machine learning (ML) modeling in initial teacher education. The aim was to examine the feasibility of this instructional approach and its association with pre-service teachers’ computational knowledge and attitudes toward programming and artificial intelligence (AI). A one-group pretest-posttest design was implemented with 129 undergraduate students enrolled in Primary Education degree programs at two public universities in Spain. Knowledge of computational concepts was assessed with a 10-item test analyzed using a paired-samples Student’s t-test, while attitudes toward programming and ML were evaluated with two Likert scales analyzed using …

William Bacon Oliver Collection, University Of Alabama School Of Law

Manuscript Collections

The William Bacon Oliver Collection consists of books, papers, memorabilia, and clothing from William Bacon Oliver, United States Representative from Alabama.

Howell Thomas Heflin Collection, University Of Alabama School Of Law

Manuscript Collections

The Howell Thomas Heflin Collection documents Heflin's years as legal reformer and Alabama State Supreme Court Chief Justice, as well as his tenure as United States Senator through press clippings, scrapbooks, speech files, audiotapes, videotapes, press releases and statements, newsletters and various printed materials, photographs, negatives, campaign materials, and memorabilia.

Kenneth Allison Roberts Collection, University Of Alabama School Of Law

Manuscript Collections

The Kenneth Allison Roberts Collection consists of documents, manuscripts, diaries, photographs, and artifacts deposited with the Bounds Law Library by the family of Congressman Roberts.

Framing Belonging And Exclusion: A Dialogic Narrative Analysis Of English- And Spanish-Language Immigration Coverage During The Trump 2024 Presidential Election, Evangeline T. Cruz

Theses and Dissertations

I investigated how English- and Spanish-language news outlets narratively constructed Latinx immigrants during the Trump 2024 presidential campaign, a period marked by heightened anti-immigrant rhetoric and political volatility. While past scholarships examined immigration framing through tone, sentiment, or frequency analysis, limited attention has been given to the deeper narrative structures that shape public meaning-making. This study addresses this gap by applying Dialogic Narrative Analysis (DNA) and Critical Thematic Analysis (CTA) to a bilingual dataset of 120 newspaper articles from The New York Times, Los Angeles Times, El Diario, and La Opinión published between November 2024 and February 2025.

Findings reveal …

Effect Of Substrate Dispersion Method And Particle Size On In Vitro Digestibility, Gas Production Kinetics And Composition, And Fermentation Characteristics In Different Feed Types, Luiz C. O. Sousa, Ellem M. A. Matos, Ronald J. Trotta, Edenio Detmann, David L. Harmon

Animal and Food Sciences Faculty Publications

Our objective was to evaluate the influence of substrate dispersion method and particle size on in vitro digestibility, gas production kinetics and composition, and fermentation characteristics of different feed types. Alfalfa hay, tall fescue hay, ground corn, soybean meal, and a total mixed ration (TMR) were used as substrates. Treatments were designed according to a 2 × 2 × 5 factorial arrangement: two substrate dispersion methods (loose substrate and in filter bags), two particle sizes (1 mm and 2 mm), and five feeds. Filter bags decreased (P ≤ 0.001) digestibility and gas production compared with loose samples. Filter bags decreased …

Soybean Meal Mitigates Vasoconstriction And Serotonin Suppression During Fescue Toxicosis In Beef Cattle, Luiz C.O. Sousa, Brittany E. Davis, David L. Harmon, Ronald J. Trotta

Animal and Food Sciences Faculty Publications

Legume supplementation has been shown to mitigate fescue toxicosis in beef cattle. However, no studies have directly compared the use of soybean-based feeds to alleviate symptoms of fescue toxicosis under controlled environmental heat and equalized feed intake. The objectives were to evaluate the effects of soybean hulls, whole soybeans, or soybean meal (SBM) supplementation on the mitigation of vasoconstriction, heat stress, and inflammatory responses in beef cattle during fescue toxicosis. Ten ruminally-cannulated Angus × Holstein steers were used in a 5 × 10 Latin rectangle design. Five treatments were evaluated: 1) non-toxic endophyte-infected tall fescue seed (NTE), 2) toxic endophyte-infected …

Stressful Life Events And Ocd Treatment: A Thematic Analysis Of Patient Perspectives, Emily E. Fenlon

Theses and Dissertations--Psychology

Trauma exposure, including interpersonal violence (IPV), is associated with increased risk and severity of obsessive-compulsive disorder (OCD). Exposure and response prevention (ERP) is the treatment of choice for OCD, yet research suggests a history of trauma and comorbid PTSD may adversely impact treatment outcomes. No studies have yet evaluated patient perspectives on the relationship between trauma, IPV and related sequelae and OCD treatment. The present study applies reflexive thematic analysis to interviews from individuals with a history of IPV who received exposure-based therapy for OCD. Interviews explored the influence of posttraumatic distress, impairment, and psychopathology on the treatment of OCD, …

Daily Rhythms In Psychosocial Stress, Sleep, And Mood: A Multimethod Approach To Transdiagnostic Psychopathology Risk And Intervention, Gabriel Gilmore

Theses and Dissertations--Psychology

Rhythms are central to nearly every core physiological and psychological process and have profound influences on overall health and well-being, particularly in the context of mood disorders. This dissertation emphasizes a rhythm-centered framework for understanding transdiagnostic psychopathology, proposing that the temporal organization of psychosocial stress, sleep, and mood provides crucial information for the development and treatment of mood disorder symptomology. Current literature relies primarily on mean symptom levels, overlooking day-to-day patterns in psychosocial experiences. To address this key methodological gap, three studies are examined. Study 1 develops and validates the Psychosocial Stress Regularity Measure (PSRM), a brief single-item measure of …

Relative Utility Governs Working Memory For Drug-Associated Stimuli In A Novel Translational Paradigm, Maxwell E. Boileau

Theses and Dissertations--Psychology

Substance use disorder (SUD) remains a prevalent health concern, partially characterized by continued drug use despite aversive consequences. Contrary to accounts emphasizing cognitive deficits, drug versus non-drug choice data reflect sensitivity to reinforcement dimensions, with preference shifting systematically as a function of magnitude and probability. The present study tested whether another cognitive system, working memory, is similarly affected by relative utility. Preclinical studies have demonstrated sensitivity of working memory to reinforcement dimensions, but these are often attributed to the differential outcomes effect. Generalized matching models were fit to allomorphic choice data, allowing estimation of exchange rate parameters. A concurrent solid- …

Working Memory In The Pigeon: An Alternative Paradigm, Daniel Peng

Theses and Dissertations--Psychology

One of the most widely used measures of working memory in non-human animals is the delayed matching to sample (DMTS) design. While this design can assess for duration of working memory, alternative accounts can be made to explain decrements in retention. In addition, DMTS does not assess capacity of working memory in terms of number of items able to be held. The works in this dissertation aims to design a paradigm to measure capacity of number of items held in memory for non-human animals by asking animals to make a specific response after presentation of a random spatial sequence. While …

The Future Of Monetary Federalism: Rethinking Supremacy In The Stablecoin Era, Richard H. Fair

American University Business Law Review

[INTRODUCTION] In the summer of 2023, the State of Wyoming enacted a law authorizing its state treasurer to issue a blockchain-based, state-backed digital stablecoin known as the Wyoming Stable Token (“WYST”). Two years later, Congress passed the Guiding and Establishing National Innovation for U.S. Stablecoins Act (GENIUS Act, GENIUS, or the Act), moving to establish a comprehensive federal regulatory regime for stablecoins. These dueling initiatives have sparked more than regulatory confusion; they have set the stage for a structural clash between state financial innovation and federal monetary supremacy. At the heart of this confrontation lies a question that the Constitution …

Peaks Island Star : January 2026, Vol. 46, Issue 1, Service Agencies Of The Island

Peaks Island Star, 2026

The Peaks Island Star is the newsletter of the island's service agencies and other community news.

Strict Scrutiny And The Viewpoint Continuum, A.G. Harmon

Scholarly Articles

Consider the following instances: A cell phone photograph picturing a man's left kneecap. A statement that the speaker thinks, "The name Josiah is really cool." A woman who runs her bicycle over a business owner in order to gain celebrity and increase attention for her new podcast. An intentional lie told to acquire a job. A student who insists on answering his math exam questions in runic symbols.

At one point or another, American courts have considered the merits found in favor of instances similar to these and other like circumstances as amounting to "viewpoints." As such, they …

Alabama Criminal Code Development Collection, University Of Alabama School Of Law

Manuscript Collections

The Alabama Criminal Code Development Collection contains copies of the Criminal Code of Alabama, original drafts and edits, and email correspondence and meeting notes regarding creation.

7-Hydroxymitragynine Induced Perioperative Hyperalgesia In 27-Year-Old Trauma Patient, William Hickman, Katherine David, Vincent Hoffman, Ruzanna Nalbandyan

South Atlantic Division GME Research Days 2026

No abstract provided.

A Low-Cost, High Fidelity Obstetric Anal Sphincter Injuries (Oasis) Repair Model, Bailey Brown, Jordan Mattern, Mary Kathryn Ball, Stephanie Tootle

South Atlantic Division GME Research Days 2026

No abstract provided.

Aortic Rupture Averted: Brucella Aortitis With Pseudoaneurysm Formation In The Southeastern United States, Nigel D'Souza, Thomas Horton

South Atlantic Division GME Research Days 2026

No abstract provided.

Korean Wedding Hanbok In The May Weber Ethnographic Study Collection, Odette Collins

Department of Anthropology

This report examines a men’s ceremonial hanbok from the May Weber Ethnographic Study Collection, attributed to South Korea in the mid-twentieth century. It discusses the garment’s materials, construction, and decorative techniques, as well as its function as wedding attire. The report situates the object within the historical context of Joseon dynasty court dress, particularly dallyeong robes, and analyzes its symbolic motifs, including crane rank badges. It also considers issues of attribution, provenance, and the broader cultural significance of hanbok in relation to class, tradition, and modern production.

Biomechanical Advancements In Hydroxyapatite, Magnesium-Substituted Hydroxyapatite, And Strontium-Substituted Hydroxyapatite In Clinical And Non-Clinical Studies For Maxillofacial Bone Tissue Engineering: A Review, Elham Zafarrazzaghnia, Stuart Hampshire, Aran Rafferty, Dermot Brabazon, Eamonn Debarra, Maura Kelleher

Articles

Hydroxyapatite (HA) is a bioceramic known for its bioactivity and osteoconductivity, which should make it an ideal candidate for maxillofacial bone regeneration. However, its brittleness limits its suitability for load-bearing applications. Over recent decades, substantial efforts have focused on enhancing its performance, particularly through ionic substitution, including magnesium-substituted HA (Mg-HA) and strontium-substituted HA (Sr-HA). This review summarises the available information on the structural, physical and mechanical properties of facial bones (maxilla, mandible, zygoma and frontal bone). The crystal structure, physical, and mechanical properties and in-vitro biological responses of dense and porous HA, Mg-HA and Sr-HA ceramics are described, with particular …

Current Regenerative Injection Treatment For Rotator Cuff Disease: A Review Article And Practical Algorithm, Abdallah El-Sayed Allam, Manal Hassanien, Ahmed Omar Mahmoud Abdallah

Rehabilitation Practice and Science

Rotator cuff disease is a prevalent musculoskeletal condition affecting shoulder function and quality of life. Traditional management includes conservative treatments and surgery, but ultrasound-guided regenerative orthobiological interventions have emerged as effective alternatives. This review examines epidemiology, risk factors, clinical presentation, and diagnostic approaches to rotator cuff disease, with an emphasis on the role of ultrasound-guided regenerative injections. Specific techniques such as platelet-rich plasma, alpha-2 macroglobulin, lipoaspirate, and bone marrow concentrate are discussed. Recent human studies highlight the efficacy and safety of these interventions, supporting their integration into clinical practice.

Sucarnochee Review - 2026 Issue, The Sucarnochee Review Editors

The Sucarnochee Review

No abstract provided.

Global Inventory Of Fluoropolymer Production Plants And Their Associated Pfas Environmental Contamination, Anna J. Miller, Kevin Kleemann, Juliane Glüge, Rainer Lohmann, Ian T. Cousins, Dorte Herzke, Mark F. Miller, Amanda Rensmo, Xenia Trier, Zhanyun Wang, Martin Scheringer

Graduate School of Oceanography Faculty Publications

Fluoropolymers are widely used across sectors, but their production is associated with emissions of perfluoroalkyl and polyfluoroalkyl substances (PFASs), which are mobile, persistent, and toxic. In this work, we compiled a global inventory of fluoropolymer production plants (FPPs) and assembled PFAS concentration measurements for various media in their vicinity. We identified 52 currently operating FPPs across 11 countries and 41 cities. For 12 FPPs, in 12 different cities, there are peer-reviewed site-specific PFAS measurements specifically attributed to the FPP. At these 12 sites, at least 236 individual PFASs have been detected across multiple environmental media, including surface water, groundwater, air, …

Preliminary Cruise Report: Tn452 Eastern Lau Spreading Center And Northeastern Lau Basin, Kingdom Of Tonga, April 19, 2026 – May 18, 2026, Roxanne A. Beinart, Shawn Arellano

Graduate School of Oceanography Faculty Publications

No abstract provided.

Building A Cell Specific System For In Vivo Rna Imaging Of The Endogenous Actin Gene In C. Elegans, Jasmine A. Huerta Canete

Theses and Dissertations

Messenger RNA (mRNA) plays a crucial role in protein synthesis and cellular processes, important for the development of cells such as neurons. When dysregulation occurs, it can lead to outcomes such as aberrant translation, causing neurodegenerative conditions to arise. Unfortunately, the localization of mRNA in an in vivo cell specific manner is still not understood. To address this, we decided to develop a cell-specific system to image RNA in vivo, within the organism known as C. elegans with a focus on the actin gene. The Actin gene encodes for an important cytoskeleton protein expressed ubiquitously, vital for the cell …