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Prevention Of Medication-Related Osteonecrosis Of The Jaw After Tooth Extraction By Local Administration Of Antibiotics And Atelocollagen Sponge: A Preliminary Study, Natsumi Nakamura, Sakiko Soutome, Akira Imakiire, Satoshi Rokutanda, Seigo Ohba, Shunsuke Sawada, Yuka Kojima, Yuki Sakamoto, Yoshiko Yamamura, Madoka Funahara, Mitsunobu Otsuru, Masahiro Umeda

Journal of Dental Sciences

Background/purpose Medication-related osteonecrosis of the jaw (MRONJ) often develops after extraction of a tooth with a local infection. Therefore, it is necessary to develop extraction methods that can prevent MRONJ. Before examining whether antibiotics and atelocollagen administered in the extraction socket can prevent the development of MRONJ after tooth extraction, this study was conducted to determine the appropriate antibiotics concentration and to conduct a clinical study with a small number of cases as a preliminary study. Materials and methods First, a mixture of minocycline and atelocollagen at different concentrations was implanted into the bone cavity formed in the rabbit head, …

Epigallocatechin Gallate In Dentistry: Therapeutic Applications, Biomaterial Integration, And Translational Challenges, Chloe Jui-Yun Chang, Fang-Yu Fan, Yung-Li Wang, Thi Thuy Tien Vo, Yang-Che Wu, Yu-Chia Chang, I-Ta Lee

Journal of Dental Sciences

Epigallocatechin gallate (EGCG), a major bioactive catechin in green tea, has attracted increasing attention in dentistry because of its antioxidant, anti-inflammatory, antimicrobial, matrix-modulating, and regenerative properties. This narrative review summarizes current evidence on the biological mechanisms, dental applications, and translational challenges of EGCG in oral healthcare. EGCG can modulate oxidative stress and inflammatory signaling pathways, including nuclear factor-kB (NF-kB), mitogen-activated protein kinase (MAPK), nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1), and NOD-like receptor family pyrin domain containing 3 (NLRP3)-related responses, and has activity against oral disease-associated microorganisms and biofilms. In periodontal therapy, EGCG has been investigated as an adjunct …

Isoliquiritigenin Represses The Pro-Fibrotic Tgf-Β/Smad2 Signaling And Nuclear Enriched Abundant Transcript 1 (Neat1) In Oral Submucous Fibrosis, Chi-Shan Tseng, Shih-Min Wang, Yi-Wen Liao, Her-Hsiung Huang, Cheng-Chia Yu, Yicyuan Chen

Journal of Dental Sciences

Background/purpose: Isoliquiritigenin (ISL) has shown anti-fibrotic potential in several organ systems, but its effects on oral submucous fibrosis (OSF) remain unclear. This study investigated whether ISL attenuates myofibroblast activities in buccal mucosal fibroblasts (BMFs) from OSF patients by modulating TGF-β/Smad2 signaling and the long non-coding RNA NEAT1.

Materials and methods: Primary normal BMFs and fibrotic BMFs (fBMFs) were isolated from human buccal mucosa, and cell viability, collagen gel contraction, migration, and wound closure were examined after ISL treatment with or without arecoline. TGF-β1 secretion was quantified, while protein expression of phosphorylated Smad2, COL1A1, and α-SMA was analyzed, and …

2-O-Methylmagnolol Suppresses Oral Squamous Cell Carcinoma Progression By Targeting C-Myc Signaling, Chi-Yuan Chen, Tzong-Ming Shieh, Chin-Chuan Chen, Yann-Lii Leu, Yu-De Chu, Miaw-Jene Liou, Yi-Tsen Liu, Hsin-Wei Lin, Kai-Yin Chen, Cheng-Chia Yu, Tong-Hong Wang

Journal of Dental Sciences

Background/purpose: Oral squamous cell carcinoma (OSCC) is characterized by aggressive growth and frequent recurrence, highlighting the need for novel targeted therapies. Magnolol, a bioactive compound derived from Magnolia officinalis, exhibits anti-tumor activity. In this study, we synthesized a methoxylated derivative, 2-O-methylmagnolol (MM1), and evaluated the anti-OSCC efficacy and underlying mechanisms of magnolol and MM1.

Materials and methods: Human OSCC cell lines (SAS and OECM1) were treated with magnolol or MM1. Cell proliferation, migration, and invasion were analyzed using functional assays. Cell-cycle distribution and apoptosis were assessed by flow cytometry and DiOC₆/PI staining. Protein expression of c-MYC and downstream regulators …

Artificial Intelligence, Fundamental Motives, And Evolutionary Mismatch, Amy J. Lim, Jose. C. Yong, Edison Sora Tan

Research Collection School of Social Sciences

In recent years, the intersection of artificial intelligence (AI) and psychology has garnered unprecedented attention, particularly following the advent of generative AI tools in 2022. These tools, capable of producing human-like text, images, and even deepening our understanding of cognitive processes, have not only captured the public imagination but also sparked new concerns and debates within the psychological community. While AI has been a subject of research for decades, the emergence of its generative capabilities has truly thrust AI into the spotlight. This article explores how these advancements are reshaping our understanding of human cognition and behavior, as well as …

Creating A Social Media Campaign, Alexa Capeloto

Open Educational Resources

Students research an issue related to social good and apply visual, news, and digital literacy skills to design an original image and a proposed social media campaign.

Assessing Fisheries Dependence Of Coastal Communities In Managed Mangrove Forests In Latin America, Ariel Alexander Quintanilla Magana

Open Access Dissertations

Fisheries dependency refers to the action of a person, community, or society linking their social, cultural, and economic actions to different ecosystem services (ES) for covering their food system with essential marine species, developing a governance system to conserve these fishing areas, their local ecological knowledge, and guaranteeing food security in the coastal areas. In Latin America, most fishing activities are practiced within three nautical miles of the shoreline, estuaries, lagoons, and mangrove forest channels, using small vessels and traditional gear such as hooks, trammel nets, and gill nets. Some coastal communities have developed their subsistence and livelihood activities in …

Assessing Sandfly & Mosquito Abundance, Richness, And Diversity In Villaflora, Ecuador: Linking Disease Vectors To Disease Risk, Carlia Rose Lopez

Student Scholarship

No abstract provided.

Comparing Consent Culture: Are Kinky People More Concerned About Consent?, Hannah Tarleton

Graduate Research Theses & Dissertations

The BDSM community has become an increasingly popular subject of study in relation to consent culture; however, the bulk of this research has been qualitative and lacks comparison to non-BDSM practitioners. The theory of planned behavior was used to design a measure comparing consent culture across 668 BDSM practitioners and non-practitioners. As predicted, the relationships specified by theory of planned behavior was replicated for both BDSM practitioners and nonpractitioners. Contrary to predictions, no significant differences were found between BDSM practitioners and non-practitioners for norms or behavioral intentions; however, BDSM practitioners reported significantly higher perceived behavioral control. Within the BDSM community, …

How Autistic Children Define Novel And Real Words, Henry James Tomiser

Graduate Research Theses & Dissertations

Word knowledge is highly valuable to Autistic individuals, and although much research has characterized Autistic children’s vocabulary breadth (i.e., the number of lexical entries), less attention has been paid to vocabulary depth (i.e., the richness with which one understands a given word). In this exploratory post-hoc study, 11 Autistic children (one assigned female at birth) participated in novel and real word learning paradigms in which child-friendly referents were paired with CVCV word forms. Participants were then asked to provide open-ended definitions of the words. Definitions were parsed into meaningful subunits, or semantic features. Semantic features were coded by type of …

Exploring Factors Predicting Teachers’ Intentions To Use Digital Games In Saudi Elementary Schools, Thamarah M. Alqahtani

Graduate Research Theses & Dissertations

Despite the potential benefits of integrating digital games in teaching and learning environments, little research has been carried out to understand the perception of elementary school teachers in the Kingdom of Saudi Arabia (KSA) towards integrating digital games into the classroom. This study aims to understand Saudi elementary teachers’ intention of using the digital games in elementary school classrooms using Theory of Planned Behavior (TPB) model, and to provide crucial insights for the KSA’s Ministry of Education’s (MOE) administrators in developing evidence-based teacher training and effective school technology-integration policies. The Theory of Planned Behavior (TPB) was used to assess Saudi …

Madness In The Mixtape: Gothic Literature And Pop Music, Nicholas Dertinger

Graduate Research Theses & Dissertations

In Gothic literature, madness has often been connected to the outliers of what is considered socially normal. This dissertation explores the enduring theme of madness, particularly the figure of the “madwoman,” in both women’s literature and in its “afterlife”—or continuing conversation with—contemporary pop music. Through a comparative analysis of songs including Kate Bush’s “Wuthering Heights” (1978), Beyoncé’s “Hold Up” (2016), Lady Gaga’s “Plastic Doll” (2020), Olivia Rodrigo’s “good 4 u” (2021), Billie Eilish’ “What Was I Made For?” (2023), Paramore’s cover of “Burning Down the House” (2024), Taylor Swift’s “mad woman” (2020) and Florence + the Machine’s “Dream Girl Evil” …

Effects Of Desiccation On Invasive Faucet Snail (Bithynia Tentaculata) And Trematode Survival, Elise Marie Jordahl

Graduate Research Theses & Dissertations

Parasitism is one of the most common and diverse life history strategies, yet relatively little is known about the role of parasites as invasive species. Invasive species, which present one of the greatest threats to biodiversity, often need to overcome adverse environmental conditions as they establish and spread in new habitats. Invasive parasites are subject to these same conditions, though the effects may be mediated through their hosts. Here, I use an invasive snail and its trematode parasites to quantify the effects of desiccation on survival to better understand how processes of invasion play out in host-parasite systems. The faucet …

Personality Theories, Leswin Laubscher

Open Education Materials

Introduction to Personality Theories

Hu308, A Selective Cannabinoid Type-2 Receptor Agonist, Mitigates Sars-Cov-2 Spike Protein-Induced Acute Lung Injury In Mice, Janette Lockett, Gregory Nicholson, Nicholas Richards, Ryan Washington, Nagaraja Nagre

Department of Biomedical and Translational Sciences Faculty Publications

Introduction

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to pose major health challenges despite effective vaccination efforts. The sustained occurrence of breakthrough infections and emerging variants of the virus highlights the need for additional therapeutic strategies. Given the anti-inflammatory role of the cannabinoid type 2 receptor (CB2R), we examined the effect of CB2R activation in SARS-CoV-2 spike protein subunit 1 (S1SP)-induced acute lung injury (ALI).

Methods

ALI was induced in mice by intratracheal (i.t.) administration of S1SP, followed by treatment with the CB2R agonist HU308 (5 mg/kg, intraperitoneal: i.p.) 1 h …

P38 Mapk Is Involved In Epigenetic Regulation Of Fibrotic Genes In Replication Induced Senescence In Lung Fibroblasts, Shan Zhu, Jennifer Q. Zhou, Kan Wang, Ming-Lei Guo, Yan Sanders

Department of Biomedical and Translational Sciences Faculty Publications

Fibroblast activation is essential for tissue repair following injury; however, prolonged activation drives pathological fibrosis. Idiopathic pulmonary fibrosis (IPF), a progressive and age-associated lung disease, is characterized by aberrant fibroblast activation, with increasing evidence implicating senescent and near-senescent fibroblasts in its pathogenesis. However, the underlying mechanisms remain poorly defined. In this study, we investigated whether histone modification is involved in TGF-β1 treated lung fibroblasts and contributes to the fibrotic phenotype. Human IMR90 lung fibroblasts at low and high population doubling levels (LPDL and HPDL), as well as primary IPF fibroblasts, were used in this study. In response to TGF-β1, both …

Senescent Fibroblasts In Aging And Pulmonary Fibrosis, Sara B. Palega, Aiwei Y. Borengasser, Yan Y. Sanders

Department of Biomedical and Translational Sciences Faculty Publications

Aging is a major risk factor for many chronic lung diseases, including Idiopathic Pulmonary Fibrosis (IPF), a fatal and incurable disease characterized by progressive fibrotic remodeling. Age-associated structural alterations, impaired regenerative capacity, and dysregulated cellular signaling collectively create a pro-fibrotic microenvironment. A central driver of this pathological shift is the accumulation of senescent cells, which undergo irreversible growth arrest and develop a robust pro-inflammatory senescence-associated secretory phenotype (SASP). Emerging evidence identifies senescent lung fibroblasts as critical mediators of IPF pathogenesis. These cells promote excessive extracellular matrix deposition, myofibroblast differentiation, and tissue stiffening, while simultaneously impairing epithelial regeneration. Together, these effects …

Characterization And Antimicrobial Activity Of Lignin-Derived Compounds In Ground Hurd Tissue Of Cannabis Sativa L. (Hemp) Cultivars, Jourdan E. Lakes, Anjam Sadik, Robert C. Pearce, Barbara L. Knutson, Stephen E. Rankin, Bert C. Lynn, Michael D. Flythe

Chemistry Faculty Publications

Objectives: Characterize lignin-derived compounds from the hurd of 10 fiber/grain Cannabis sativa L. cultivars and investigate the antimicrobial activity of select compounds on the wasteful ruminant bacterium, Acetoanaerobium sticklandii SR.   Methods: Hurd was processed using an aqueous ethanol solvent system and analyzed via GC-MS to identify and characterize lignin derivatives. Antimicrobial activity of the hurd and three monomers was assessed using solid (hurd) and liquid medium (monomers) bioassays against SR.   Results: 27 compounds were identified, most as monomers but a few were dimers, ethylated derivatives, and organic acids. There were approximately equal G- and S-units with substantially fewer H-units. Several …

“None In Velvet Gowns”: Camp Followers And White Womanhood In Eighteenth-Century Anglo-American Warfare, Angelica Labren Torres

History Theses

For over two hundred years, women who followed American and European armies during the long eighteenth century were popularly stereotyped and denigrated as prostitutes, burdens, and generally individuals of ill repute by both contemporaries and subsequent generations of historians. While recent scholarship has largely debunked this long-standing characterization as simplistic and inaccurate, the question remains: why exactly were these women so mischaracterized in their own time, particularly by commissioned officers and other members of Anglo-American middling and elite classes, when ample evidence existed of their material usefulness and comparative marital fidelity? This thesis seeks to address the ideological and cultural …

Analytical Commentary And Performer's Guide To Carlos R. Martinez's Four Pieces For Trombone, Bailey Jean Hardy-Price

Theses and Dissertations--Music

Musicians with hearing loss are documented in prominent figures, such as Ludwig van Beethoven. In the age of developing medical technology, hearing aids can turn the course for many musicians. Music can serve as an audio medium for this journey.

Carlos R. Martinez (b. 1978) is an active composer and pianist commissioned to create a piece that explores the journey of hearing loss in a musician. Martinez’s Four Pieces for Trombone and Piano illustrate a musician’s discovery of their hearing loss, its consequences, and joy in implementing the use of a hearing aid. The detailed discussion of the composer and …

A Critical Perspective On The Society Of Environmental Toxicology And Chemistry's Adherence To Founding Principles— Opportunities For The Future, Barnett A. Rattner, Annegaaike Leopold, Carys L. Mitchelmore, Glenn W. Suter, Mark S. Johnson, Adriana C. Bejarano, Lawrence A. Kapustka, Niranjana Krishnan, Derek C. G. Muir, Beatrice O. Opeolu, Martha Georgina Orozco-Medina, April Reed, Bruce W. Vigon, Adam R. Wronski

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

The Society of Environmental Toxicology and Chemistry (SETAC) is a global organization whose mission is the advancement of environmental science and management through collaboration, leadership, communication and education. On SETAC's 45th anniversary, the following question was raised: Are the 1979 founding principles of SETAC, multidisciplinary approaches to solving environmental problems, multisector engagement and scientific objectivity, still useful, adequate and effective in fulfilling its mission? In a special session held at the 45th Annual Meeting in Fort Worth, Texas, United States, a critical evaluation of the founding principles was initiated by reviewing SETAC's history and ongoing activities, and recommendations were made …

Characteristics Of Women Who Fast During Pregnancy: Findings From The Kuwait Birth Cohort Study, Abdullah Al-Taiar, Ali H. Ziyab, Reem Al Sabah, Ahmed N. Albatineh, James Blando, Majeda S. Hammoud

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Fasting during pregnancy is a widespread practice in Muslim communities, yet its health implications remain poorly understood. A lack of conceptual frameworks and limited understanding of the characteristics of women who fast during pregnancy have hindered research in this area. This study examines the differences in several nutritional biomarkers between women who fasted and those who did not and identifies factors associated with fasting behaviour. We analysed data from the Kuwait Birth Cohort in which information on fasting, sociodemographic characteristics and health behaviours was collected via structured interviews between 2017 and 2021. Clinical and laboratory data were extracted from medical …

Monetary Sovereignty In Peril? Cryptocurrencies, Capital Controls And Exchange-Rate Volatility: A Quantitative Global Analysis, Mckeown Boadi Owusu

Graduate Research Theses & Dissertations

This thesis examines whether the rise of cryptocurrencies affects the constraints states face in exercising monetary sovereignty, specifically in stabilizing their currencies. The analysis tests two hypotheses: first, that higher levels of cryptocurrency interests are associated with greater exchange-rate volatility; and second, that this relationship is stronger in countries with more stringent capital-flow management measures. Drawing on a panel dataset of country–month observations across 46 countries from 2017 to 2024, The results provide no consistent evidence that cryptocurrency interest is directly associated with higher exchange-rate volatility. Similarly, the interaction between cryptocurrency interest and capital controls remains insignificant across all models, …

Management-Driven Shifts In The Bison Fecal Microbiome And Its Relationship To Stec Prevalence, Ritesh Ray

Graduate Research Theses & Dissertations

Contamination of meat samples from pathogens such as Shiga toxin-producing E. coli (STEC), especially in ruminants, is an ever-growing issue for the safety of global meat production. Recent studies have reported STEC in the livestock and food industry with a limited focus on wildlife. Although cattle serve as the primary reservoir for STEC, American bison (Bison bison bison) is the largest ruminant inhabiting North America, sharing similar genetics, and grazing habits, making them an ideal alternative STEC reservoir. Re-introduction for prairie conservation and meat farming has brought bison herds closer to anthropic environments than before. Recently bison meat has become …

Supporting First-Generation College Student Success Through Increased Participation In High-Impact Academic Practices, Michael Daly

University of the Pacific Theses and Dissertations

First-generation college students, those with neither parent having earned a bachelor’s degree, represent approximately one-third of all students attending college in the United States. Many enter college not fully prepared for success and, despite decades of research and the development of a variety of student support interventions, substantial and lasting improvements in their institutional retention and graduation rates on a national level have been elusive. This persistent issue creates a variety of negative consequences for the students, the institutions they attend, and society. The purpose of this action research study was to develop recommendations for improving the practice of supporting …

Expectations In The Preservation Of Dna And Bacterial Organisms In Differential Montana Burials, Kaylee M. Hinds

Graduate Student Theses, Dissertations, & Professional Papers

This study investigates patterns of decomposition and biomolecular preservation in domestic pig (Sus scrofa domesticus) proxies under varying burial conditions in a cold, seasonal climate. Conducted at the Lubrecht Experimental Forest in western Montana, the project aims to evaluate DNA degradation, microbial activity, and environmental influences across shallow, deep, surface, and secondary burial contexts. Three pigs were placed in distinct burial treatments (surface exposure, partial burial, and full burial), with a fourth site later added following bear disturbance and carcass relocation. Environmental monitoring included temperature, and soil sampling before and throughout the decomposition process. Systematic sampling of bone, soft tissue, …

Thistlebloom Moondog, Gary W. Jensen

Graduate Student Theses, Dissertations, & Professional Papers

An aging grieving artist decides to write a memoir as part of a self-healing process, using samples of song lyrics from his extensive collection of original Americana songs as narrative prompts.  Steeped in wanderlust, aspiration, paradox and dysfunction, his is a tale of vexing sub-clinical troubles rooted in the mire of developmental and religious trauma.

The Golden Rule: An Msw Portfolio Narrative, Russell Jared Jacobs

Graduate Student Portfolios, Professional Papers, and Capstone Projects

The experiences and research behind Russell "Jared" Jacobs' MSW journey that showcases his abilities in the field of social work.

¡Salud! Sacrificing The Sacred Sip: A Critical Analysis Of The Impact Of The Spiritual Conquest On Alcohol Traditions In Central México, Elizabeth Vilchis

Graduate Theses/Dissertations

By thoroughly investigating the available primary sources, this thesis will convey the importance of the Mesoamerican inebriating drink pulque in both the ethos and mythos of ancient Nahua society, examining how the ritual use of pulque became problematic in the eyes of the Spaniards, by investigating the cultural and ideological contradictions or double standards that enabled the tensions, struggles, and violence with which the Spanish colonial regime repressed the ritual use of pulque. This thesis compares the Nahua ethos and mythos of pulque to the Christian ethos and mythos of wine, highlighting the parallels perceived by Spaniards in Central México …

Characterization Of The Effects Of Atp On Primary Brainstem Glial Cells, Donovan J. Aardema Faigh

Graduate Theses/Dissertations

Migraine and temporomandibular joint disorder (TMD) are debilitating orofacial pain disorders that negatively impact one’s quality of life. These disorders are characterized by elevated levels of adenosine triphosphate (ATP) and activation of central nervous system glial cells that promote and maintain central sensitization and enhance pain signaling in response to inflammatory stimuli. The goal of my study was to characterize the effects of the pro-inflammatory signaling molecule adenosine triphosphate (ATP) on intracellular calcium levels, mRNA levels, and protein expression in astrocytes, microglia, and oligodendrocytes to better understand the role of ATP in promoting central sensitization. To address this goal, primary …