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The Role Of Vitamin D In Management Of Pediatric Chronic Immune Thrombocytopenia, Eman Magdy Yahia, Suzy Abd El Mabood Abd El Hameed, Dalia Tawfeek Hussein, Amany Mamdouh Shoumah

Mansoura Medical Journal

In children, immune thrombocytopenia (ITP) remains a serious health concern, which is an autoimmune disorder (AID) characterized by an isolated decrease in platelet count, leading to an increased risk of bleeding.

The use of vitamin D supplementation represents a turning point in many autoimmune diseases, with the potential to deliver high cure rates with fewer side effects than previous therapies. In this review, we explore the incidence of ITP , immunopathogenesis, diagnosis and management in pediatric patients. We will discuss the mechanisms of action of vitamin D , focusing on its role in autoimmune diseases especially ITP

The Potential Role Of Naftidrofuryl Oxalate In Rat Model Of Ulcerative Colitis, Omar Mohsen Elmazny, Ahmed Abdel-Monem Elmetwally, Vivian Boshra, H.M. El-Beltagi, Basma Hamed Othman, Heba Sheta

Mansoura Medical Journal

Background: Ulcerative colitis (UC) is a chronic, recurrent bowel disease characterized by inflammation that leads to superficial damage to the colon wall. The rate of incidence of UC differs from 0.5 to 31.5 per 100,000 subjects annually. The exact cause is still not well-identified. Studies suggest genetic factors, altered immune response, and environmental factors may play a role in the initiation and progression of the disease. Its pharmacological treatment remains unsatisfactory. Aim: To assess the possible protective effect of Naftidrofuryl oxalate (NFT) (praxilene) on intestinal epithelial cells in acetic acid (AA)-induced UC model in rats.  Materials and Methods: sixty female …

Active Deresuscitation Strategies After Septic Shock: A Scoping Review, Alrefaey K. Alrefaey, Rania E Elbadrawy, Mohamed Aboelela, Mohammed Mamoun

Mansoura Medical Journal

Background: Fluid overload in septic shock patients is linked to higher morbidity and mortality. After the stabilization phase, fluid restriction may not result in the resolution of tissue edema. Active deresuscitation refers to the use of diuretics or ultrafiltration for the removal of excess fluids. Objectives: This review explores the current practices applied for the active deresuscitation strategies after stabilization of septic shock patients.  Search strategy: A literature search was performed through the following databases: Medline, PubMed, Google Scholar, Web of Science, and Scopus for relevant studies from 2015 to January 2026. Selection criteria:  The selected articles included …

The Biosynthesis Of The Natural Product N-Nitroglycine, Gabriel Padilla

Graduate Studies Theses and Dissertations 2026

N-Nitroglycine (NNG) is a nitramine [R(R′)N–NO2; R′=H or alkyl] natural product (NP) produced by certain actinomycetes, such as Streptomyces noursei. At the beginning of this project, the biosynthesis of this NP was unknown. The goal was to determine how NNG and its nitramine moiety are enzymatically formed. This could lead to the discovery of novel nitramine NPs with diverse applications as well as alternative/green synthesis of nitramine explosives. This work begins by examining diverse biochemical N–N bond formation strategies. Nitrogen cycle enzymes, nitration of NPs, kutzneride biosynthesis, the aspartate/nitrosuccinate superfamily, hydrazinoacetic acid (HAA) biosynthesis, and streptozocin biosynthesis are among the …

Beyond The Square Pulse: Waveform Shape, Eeg Correlates, And The Pursuit Of Natural Sensation In Tens, Jason Whitson

Honors Undergraduate Theses

This study investigates the relationship between electrical stimulus characteristics of shape and charge on evoked sensations and electroencephalogram (EEG) data during multi-waveform transcutaneous electrical nerve stimulation (TENS) of the median nerve. Neuromodulation methods have traditionally had little control over the location and quality of their associated evoked sensation (e.g., electric, vibration, touch). This experiment utilized five unique stimulus waveforms during TENS stimulation. EEG data were collected concurrently to provide an introductory objective measure of the neural responses underlying these sensory changes. Eleven participants completed three tasks (thresholding, super-threshold stimulation, two-alternative forced choice) using a two-electrode TENS approach. Stimulus waveforms were …

Exploring Associations Between Mental Disorder And Creativity, David A. Romero Mora

Honors Undergraduate Theses

Mental disorder has been misunderstood and misrepresented throughout history, leading mental health research to be severely behind where it needs to be. Years of misinformation, over-medicalization, negative rhetoric, and stigmatization at the hands of the very same institutions that were believed to care for mental disorder have kept this misunderstanding alive. Further, studies throughout history have failed to look at the nuances of mental health, prioritizing generalizability. This thesis explores the relationship between mental disorder and creative expression, how other factors like cultural discourse and cognitive processes inform this relationship, as well as how analyzing this relationship can provide a …

Comparative Analysis Of Left Ventricular Sympathetic Axons In Shr And Wky Rats, Parker R. Tyson

Honors Undergraduate Theses

Hypertension is a leading cause of cardiovascular morbidity and mortality and is strongly associated with dysregulation of the sympathetic nervous system, which plays a central role in controlling heart rate, vascular tone, and blood pressure. Although increased sympathetic activity has been widely documented in hypertensive disease, the precise structural organization of sympathetic innervation within the hypertensive heart remains incompletely characterized. This study investigates whether chronic hypertension is associated with structural remodeling of sympathetic axons in the left ventricle by comparing autonomic innervation patterns between spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). Hearts were collected following transcardial perfusion …

Complexity Theory And Environmental Conservation Management: A Case Study With Coyote And Red Wolf Hybridization, Gretchen E. Mahalic

Honors Undergraduate Theses

Conservation biology and invasion biology are value-led scientific disciplines founded on environmental advocacy, operating at the intersection of research and action. Though these disciplines are known for their scientific veracity, unexamined values are often promulgated without scrutiny and drive decisions that work against good ecological outcomes. A case in point is that coyotes migrating into southeastern territory are framed as the greatest threat to the conservation of the endangered red wolf because hybridization is seen as diminishing their species integrity. Applying Val Plumwood’s ecofeminist account of dualistic frameworks, I will use this case to show how the vilification of the …

Investigating Effects Of The Macroalga Caulerpa Prolifera On Restoration Of The Seagrass Halodule Wrightii In The Indian River Lagoon, Florida, Luciana M. Banquero

Graduate Studies Theses and Dissertations 2026

Seagrass restoration efforts have been motivated by global decreases in coverage associated with anthropogenic influences on the environment. In the Indian River Lagoon (IRL), FL, seagrass declined by 75% between 2011 and 2021. During this time, abundance of the macroalga Caulerpa prolifera increased substantially in the IRL. The macroalga is native to this estuary, however C. prolifera abundance has fluctuated widely in the past few decades. Being highly opportunistic, C. prolifera took advantage of areas formerly inhabited by seagrass. It is not known how dense, continuous beds of C. prolifera impact seagrass restoration projects or natural recovery of seagrass. Previous …

Quantifying The Effects Of Anthropogenic Disturbance On Two Marine Mammal Species With Agent-Based Models, Landon S. Myers

Graduate Studies Theses and Dissertations 2026

This dissertation details the construction and results from two agent-based models (ABMs) that quantify the effects of anthropogenic disturbance on very different marine mammals.  Most would agree the anthropogenic effects on animals are “bad”; the unknown is “how bad.”  Chapter 1 describes the ABM assessing the mortality risk from seagrass loss and the potential loss of a warm water refuge on manatees living in Florida ‘s Indian River Lagoon (IRL).  IRL manatees are at the northern habitat limit and susceptible to hypothermic mortality, and utilize natural and artificial warm water refuges to maintain core temperature.  Combined with reduced seagrass availability, …

Come And See: Exploring Complex Dynamics And Abjection Through A Southern Gothic Family Portrait, Lenee N. Peterson

Graduate Studies Theses and Dissertations 2026

“COME AND SEE: Exploring Abject Theory Through a Southern Gothic Family Portrait” examines the artist’s complex familial upbringing through the visual and narrative traditions of Southern Gothic art. Drawing upon abject theory and the cultural references of folk horror and Southern Gothicism, this thesis positions the family portrait where intimacy, trauma, and cultural inheritance collide. The project argues that direct confrontation with abjection can foster recognition, shared experience, and the possibility of collective healing. Grounded in practice-based research, this work functions as a critical and creative response to familial strain shaped by scarcity, social oppression, and emotional precarity. Through a …

Monitoring Shifts In Estuarine Microbial Communities: A Dna-Metabarcoding Approach, Ashley M. Reaume

Graduate Studies Theses and Dissertations 2026

Estuarine microbial communities, including plankton, algae, and bacteria, play important roles in nutrient cycling and food web structure. They are sensitive to changes in abiotic conditions, and shifts in community composition can provide insight into estuarine ecosystem functioning in the face of various physiochemical and anthropogenic stressors. Therefore, monitoring these communities is essential for understanding and maintaining estuarine health. DNA metabarcoding is an emerging technique for enhancing biological monitoring, allowing for the detection of multiple species within a single sample. This dissertation first focuses on how methodological decisions impact DNA metabarcoding results and then implements these optimized methods to perform …

Distributional Reinforcement Theory, Girardeau A. Spann

Georgetown Law Faculty Publications and Other Works

As Donald Trump’s assault on Diversity, Equity, and Inclusion (DEI) reveals, the concept of racial equality is sufficiently malleable that what used to be viewed as remedies for discrimination against racial minorities can now be recharacterized as reverse discrimination against the White majority. Such recharacterization is possible because the concept of equality itself lacks any stable meaning that exists independent of one’s normative preferences about race. In a democracy, normative disputes are properly resolved through the political process, unless there is some representation reinforcement defect that makes judicial intervention necessary to ensure compliance with our second order constitutional equality principle. …

Phytoremediation Potential Of Selected Plant Species (Ambrosia Artemisiifolia L. And Erigeron Canadensis L.) For Reducing Priority Heavy Metal And Metalloid (As, Cd, Cr, Cu, Hg, Pb, Zn) Contamination In Anthropogenically Impacted Soils Of Ukraine, Volodymyr Laptiev

Theses

Soil contamination with priority heavy metals and metalloids of anthropogenic origin represents one of the most pressing environmental challenges of the present day, directly associated with risks to public health, ecosystem degradation, and the achievement of the Sustainable Development Goals, particularly those of the World Health Organization and the United Nations aimed at ensuring a healthy environment, safe ecosystems, and sustainable land management. Under conditions of long-term technogenic pressure, compounded by the additional impact of military activities on the territory of Ukraine, the search for scientifically substantiated, environmentally safe, and economically feasible approaches to reducing soil contamination has become especially …

State Of New Mexico V. Meta, New Mexico Judicial District Court

Historical and Topical Legal Documents

No abstract provided.

We Need New Books, Liz Thackeray Nelson, Mandy Luszeck

The Utah English Journal

It’s College Day for incoming freshmen, and several English Department faculty and prospective students gather together for lunch to discuss English Department culture, tips for student success, and any other questions students have. Partway through, one freshman student asks what our favorite classical works are. My mind draws a blank, and I (Mandy) keep my mouth shut. It has been years since I have engaged in classic works. Or picked one up for that matter. I know the handful I taught in high school fairly well—To Kill a Mockingbird, The Great Gatsby (so much Gatsby), The Crucible. …

Mystics, Oracles, And Bones: Spiritual Resistance For Justice, Healing, And Resolution, Leah Hollis

Comparative Civilizations Review

This conceptual essay examines the enduring human impulse to seek meaning, justice, and healing through mystical traditions in response to suffering and harm. When traditional solutions through grievance, the law, or mediation fails, some individuals may turn to spiritual practices not as superstition, but as embodied strategies of survival, reclamation, and clarity. Comparing diverse traditions from a variety of cultures, including oracle bone divination in ancient China, the Oracle at Delphi in Greece, West African Ifá, Benin’s Voudou, diasporic Hoodoo, Celtic Druidic law, and Sufi mysticism, this paper explores how mystics have long served as interpreters of suffering and perceived …

Moody V. Netchoice And Telecom Law's First Amendment, Blake Reid

Publications

No abstract provided.

Against A Medical Exception To Equal Protection, Govind Persad

Publications

Government regulations of medicine sometimes treat patients differently based on their race or sex. Does heightened scrutiny apply to such regulations—as is usual when law treats someone differently based on a protected characteristic? Or is there a medical exception to equal protection?

Recently, in United States v. Skrmetti, the Supreme Court upheld a law that restricted access to medical treatments for transgender minors. Though its holding did not rely on medical exceptionalism, its discussion reinvigorated interest in a "medical exception" to equal protection: that medical decisions are exempt from the searching review applied when governmental decisions consider protected characteristics.

For …

Adversarial Certification Of Evidentiary Software, Nicholas G. Vincent, Bryan H. Choi, Eli Siems, Clay Halbert, Katherine J. Strandburg

Publications

No abstract provided.

State Constitutionalism's Fragile Wall, Adam B. Sopko

Publications

The adequate and independent state grounds (AISG) doctrine has long demarcated the perimeter of the U.S. Supreme Court’s authority to review state court decisions, limiting review to questions of federal law. AISG maintains the Court’s primacy over federal law and state courts’ supremacy over state law. A comprehensive review of all filings on the Court’s docket from state courts over the last twenty years reveals that recent applications of AISG consist of subtle but significant departures from existing norms that, together, suggest a reformulation of the Court’s power over state courts that threatens their sovereign law development role. This Essay …

Detection And Discrimination Of Targets In Infrared Imagery, Adam T. Cuellar

Graduate Studies Theses and Dissertations 2026

Automated infrared (IR) imagery analysis is essential for persistent surveillance, defense, and security, yet it remains difficult when sensors move and when unknown objects appear. This dissertation addresses two fundamental problems: (1) detecting small moving targets amid platform-motion induced parallax and (2) distinguishing between known stationary targets and out-of-distribution (OOD) objects.   For detecting moving targets while the platform itself is in motion, auxiliary Global Positioning System and Inertial Navigation System data are combined with image analysis. Direction Cosine Matrices from calibrated inertial measurements enable sub-pixel frame alignment unattainable with purely image-based registration. The stabilized sequence is processed by a Reed–Xiaoli …

Establishment Of An In Vitro Dss-Induced Epithelial Injury Model To Investigate Il-6 Signaling And Microbial Metabolite Mediated Barrier Recovery, Srijal Kunwar

Graduate Studies Theses and Dissertations 2026

Dextran sodium sulphate (DSS) is widely used in vivo to induce epithelial injury; however, the molecular effects of DSS on intestinal epithelial cells, that investigate inflammatory and metabolic repair mechanisms remain unclear. Here, we establish an in vitro DSS-induced epithelial damage model using differentiated Caco-2 cell monolayer. Exposure to 2.5%(w/v) DSS for 24 hours resulted in significant upregulation of pore forming protein Claudin-2(2.677-fold) and oxidative marker, NOX-1(1.866-fold), accompanied by increased ROS production confirmed via DHE staining. Increased epithelial permeability was observed by TEER analysis, without significant cytotoxicity. Surprisingly, ELISA analysis revealed significant downregulation of IL-6 (p-value …

Mapping Cave Vulnerability And Priority Areas For Biospeleological Conservation, C. Lael Anderson

Theses

Alabama contains some of the highest levels of subterranean biodiversity in North America, yet no statewide assessment of cave vulnerability has previously been conducted. A spatially explicit vulnerability assessment was developed for Alabama caves using species occurrence records, landscape characteristics, anthropogenic threat data, and groundwater vulnerability metrics. Distribution maps were generated for cave- obligate and bat species, and vulnerability was assessed using human population, land- use, groundwater quality, groundwater quantity, and modified DRASTIK models. Results identified numerous single-site endemic species, regional biodiversity hotspots, and cave systems facing elevated anthropogenic threats. Conservation priority rankings highlighted species and caves of greatest management …

Gendered Resistance: Women’S Strategies Against Military Dictatorships, Argentina And Chile, Maricarmen Canales-Moreno

Publications and Research

This article compares the Madres de Plaza de Mayo in Argentina and the Agrupación de Familiares de Detenidos Desaparecidos (AFDD) in Chile to examine how women transformed their identities as mothers, wives, and daughters into strategies of political resistance under military dictatorship. It argues that maternal imagery, public mourning, and the transformation of private grief into collective defiance enabled women-led human rights organizations to challenge authoritarian regimes while strategically drawing on gender roles those regimes sought to enforce. The article traces the emergence of both organizations, their occupation of public space, hunger strikes, legal action, and engagement with international human …

Careless Responding: Testing The Theory Of Vigilance, Rusty Wilson

Graduate Studies Theses and Dissertations 2026

Careless responding (CR) has been identified as a threat to the psychometric integrity of cognitive and non-cognitive tests, with much of the current research focusing on the identification and removal of carelessness from dataset. While this research has proved fruitful in improving data quality, there has been a recent push to move towards preventing carelessness as opposed to post-hoc removal, which harms statistical power. However, the most common prevention strategy to prevent carelessness (pre-survey warnings) has shown equivocal effects. Additionally, the literature lacks an agreed upon theory to explain why carelessness occurs. To address these gaps I introduce theory from …

Staging Violence With Intentionality, Toby O'Brien

Theses and Dissertations

This thesis examines the role of the fight choreographer in the theatre while addressing the potential issues staged violence has in distracting an audience from the intended narrative of the play. Avoiding the instruction manual approach of stage combat in favor of expounding on the theory of violent entertainment, I have constructed a thesis that informs the reader of certain types of violence found in both classical and modern productions and have researched the psychological ramifications of violent spectatorship and the necessity for content acknowledgements as well as consideration for the performer’s well-being. By exploring the history of violent entertainment …

An Integrated Data-Driven Framework For Arctic Shipping: Analyzing Vessel Speed, Environmental And Ecological Factors Through Innovative Statistical Spatio-Temporal Methods, Inverse Optimization And Machine Learning, Mauli Pant

Theses and Dissertations

This dissertation develops an integrated data-driven framework to analyze vessel navigation and ecological risk in the United States Arctic from 2010 to 2019. As environmental change and maritime activity increase in the region, understanding how vessels respond to dynamic conditions and how those responses interact with marine ecosystems has become increasingly important. A central theme of this dissertation is the treatment of vessel speed as both an observed outcome and a decision variable reflecting trade- offs among operational, environmental, and ecological factors. The first chapter develops a predictive framework for vessel speed over ground (SOG) using Gaussian Process Boosting (GPBoost), …

Gz17.602, A Combination Of Three Nutraceuticals, Interacts With Carboplatin And Etoposide To Kill Neuroblastoma, Michael R. Booth

Theses and Dissertations

This study examined the efficacy of GZ17.602, a combination of Harmine, Isovanillin, and Curcumin as a therapeutic for MYCN-amplified Neuroblastoma, both alone and in combination with standard of care chemotherapeutics. This was done due to the low survival rate associated with these neuroblastomas, the large degree of morbidity associated with current treatments, previous experiments in the Dent lab having shown 602 as effective for killing cancers of other types, and the current lack of understanding of the biology of GZ17.602 in solid pediatric cancers. Due to the GZ17.602 components being present at different concentrations in tumors than those administered, the …

My Mouth Is A Glutton, My Mouth Is A Lover., Cole Kamerick Eller

Theses and Dissertations

This thesis is a reflection on my relationship with jewelry. I discuss the impact of jewelry

and its materials. What are the ramifications of these objects? Politically, socially, and

spiritually. I reflect on material agency, cultural unconscious, and value systems, and

how I relate to jewelry, my love for it, and my grief for it. This work is the result of ritual

and impulse. The writing is my reflection on the results of that ritual.