Digital Commons Network^™

Epigenetic Hangovers: Your Brain On Alcohol, Cindy Chen

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Ctrl + Alt + Neuron, Stuart Hilton

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

What The Body Feels, The Mind Reveals: How Inflammation Shapes Emotions, Jamie Murphy

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Smile! Your Brain Is On Camera, Natalie Stone

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

When Empathy Goes Quiet, Miko Warshaw

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

“Ora’S Deep Lament”: Inspired By Mk Rawlings And My Persevering Pioneer Great-Grandmother, Kathlyne Mcdonald Walkup Sheppard

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

Human Perceptions Of Social Intelligence In Large Language Models, Derek Koehl

Dissertations

This dissertation investigates how users form perceptions of social intelligence and trust when interacting with large language model chatbots. Three experimental studies manipulated chatbot agreeableness, goal orientation, and simulated short-term memory, measuring perceived social intelligence and trust. The primary finding is an asymmetric effect of personality: disagreeable chatbot behavior produced large reductions in perceived social intelligence and trust, whereas agreeable behavior produced negligible gains above a warm baseline, consistent with negativity bias in social cognition. Goal orientation did not independently enhance perceptions but functioned as a contextual moderator. Simulated memory produced medium-to-large increases in perceived social intelligence without reliably increasing …

Quantitative Metabolomics And ¹³C-Enrichment Analysis Of The Effects Of Fat10 Overexpression On Serum And Hepatocytes, Emily C. Hunt

Dissertations

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease, is associated with obesity and type 2 diabetes, and as the prevalence of these conditions increases, the incidence of MASLD is expected to rise. However, the mechanisms that underlie the development of MASLD are complex and incompletely understood. Previous work from our group has indicated that the human leukocyte antigen-F adjacent transcript (Fat10) is overexpressed in the LEW.1WR1 rat model, which develops features of MASLD. The objective of this work was to quantify metabolites associated with MASLD in response to Fat10 overexpression. To achieve this end, we …

Contributor Biographies

Digressions: Literary & Art Journal

No abstract provided.

Rna-Micelles As Self-Assembling Structures For Efficient Co-Delivery Of Synergistic Sirna And Nucleoside Analogues To Treat Crc Lung Metastasis, Kai Jin, Piotr G. Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo

Markey Cancer Center Faculty Publications

SiRNA has been widely studied in cancer gene silencing over the last 25 years. However, few siRNA-based therapeutics have been approved by the FDA. An RNA-micelle platform provides a powerful therapeutic tool through simple one-step, high-yield production that is capable of efficient colorectal cancer lung metastasis treatment, a current lethal condition with a short survival rate post-diagnosis. Here, it is reported that the use of RNA-micelles co-carrying siRNA and nucleoside analogues to completely inhibit lung metastasis of colorectal cancer (CRC). The major advantage of the RNA-micelle is the successful co-delivery of siRNA and chemotherapeutic agent in a single delivery vehicle …

Eef2k Promotes Immune Evasion In Melanoma Via Cyclin D1–Mediated Stabilization Of Pd-L1, Yijie Ren, Darby J. Ballard, Anil Kumar, Andy F. Song, Mitiksha Gupta, Xiaofang Xiong, Xingcong Ren, Jugal Kishore Das, Jin-Ming Yang, Jianxun Song

Markey Cancer Center Faculty Publications

Eukaryotic elongation factor 2 kinase (eEF2K) is a stress-responsive regulator of protein synthesis implicated in melanoma progression, but its role in tumor immune evasion remains poorly defined. We investigated how eEF2K influences programmed death ligand 1 (PD-L1) expression through modulation of Cyclin D1. We analyzed gene expression and dependency datasets from The Cancer Genome Atlas and the Cancer Dependency Map. Protein–protein interactions were assessed by co-immunoprecipitation. Cyclin D1 was inhibited pharmacologically with palbociclib. Immune responses were evaluated in murine B16-OVA and human A2058 melanoma models using flow cytometry and immunohistochemistry after genetic or pharmacologic modulation of eEF2K and Cyclin D1. …

Characteristics Of The Health-Associated Oral Microbiome In Young Nonhuman Primates, J. L. Ebersole, O. A. Gonzalez

Markey Cancer Center Faculty Publications

Nonhuman primates have been shown to develop periodontitis with clinical and demographic features similar to humans. This preclinical disease model is well-positioned to advance the elucidation of novel biologic-based preventive and therapeutic approaches to controlling periodontitis, a chronic infection and immunoinflammatory disease. In this analysis, the oral microbiomes of younger (10–19 human years; n = 30) nonhuman primates are compared for matriline (an indicator of heritability), sex, and age variations. A holistic assessment of the microbiome similarities/differences suggested two primary conclusions in this younger group of orally healthy nonhuman primates. First, at the microbiome level of phyla, orders, and families, …

Rhythmic Gymnastics Gesture Animation, Tyriana White

Digressions: Literary & Art Journal

No abstract provided.

Cost-Aware Predictive Routing For Vision-Language Models, Sahil Sait Naveed

Master's Projects

Vision-language models (VLMs) are increasingly used for multimodal tasks, but their inference costs vary widely across model tiers. This work presents a predictive routing framework that assigns each query to the most cost-effective VLM by using multimodal embeddings, clustering, and per-cluster model error estimates. Evaluated on six commercial VLMs, the selected router reduces average cost by about 49 percent relative to the quality-first setting on both validation and test. This comes with accuracy losses of 0.4 percentage points on validation and 0.9 on held-out test data. It also outperforms K-NN and ZeroRouter routing baselines while providing lowercost operating points than …

How Wasteful Is Signaling?, Alex Frankel

Cowles Foundation Discussion Papers

Signaling is wasteful. But how wasteful? We study the fraction of surplus dissipated in a separating equilibrium. For isoelastic environments, this waste ratio has a simple formula: β/(β + σ), where β is the benefit elasticity (reward to higher perception) and σ is the elasticity of higher types’ relative cost advantage. The ratio is constant across types and independent of other parameters, including convexity of cost in the signal. A constant waste ratio characterizes the isoelastic class. In winner-take-all signaling tournaments with N candidates, exactly (N − 1)/N of the surplus dissipates—the same as in Tullock contests.

The Trade-Off Between Quality And Quantity: Evidence From A Field Experiment On Tutoring, Rohen Shaw

Cowles Foundation Discussion Papers

High-dosage tutoring has the potential to substantially raise adolescent academic achievement, but schools may lack the resources to deliver small-group tutoring frequently at scale. This paper studies the relative importance of tutoring group size (quality) versus tutoring frequency (quantity) using a randomized controlled trial in a Midwestern U.S. charter middle school. Students were randomized to a control group, tutoring twice a week in 2-student groups, or tutoring three times a week in 3-student groups, with equal total cost per student across the two treatment arms. The results show that tutoring in 2-student groups led to a statistically significant improvement in …

Moréteau On Law, Language & Heritage, Agustin Parise, Mariano Vitetta, Michel Séjean

All Scholarship

No abstract provided.

The Confidence-Man Goes To The Moving Panorama: Herman Melville’S Confidence Narrator And United States Imperialism, Bradley J. Lee

Graduate Theses/Dissertations

This thesis argues that Herman Melville fashioned his novel The Confidence-Man; His Masquerade (1857) after the moving panorama, a popular entertainment technology contemporary with the novel. More specifically, the thesis argues that the novel recalls Banvard’s Mississippi Panorama (1846). Using Jay Leyda’s The Melville Log and John Hanners’ record of Banvard’s performances, I establish beyond reasonable doubt the possibility that Melville saw this painting, or, at the very least, was aware of it, its content, and its social position. Tracing the novel’s engagement with this panorama reveals what seems at first to be its imperialist, Manifest Destinarian undertones. The novel’s …

Monopolizing The Harvest: Corporate Influence And Regulatory Gaps In Global Seed Governance, Mia Mahmudur Rahim

Vanderbilt Journal of Transnational Law

No abstract provided.

Breast Milk Versus Formula Feeding In The Development Of Necrotizing Enterocolitis Among Nicu Infants: An Integrative Review, Mackenzie Jameson, Faye Li, Liudmila Ryzhova, Mia Smith

Master's Projects

Introduction/Question: NEC is a serious condition characterized by the death of intestinal tissue, primarily affecting premature infants or those with low birth weight. The incidence of NEC poses a significant concern in neonatal healthcare due to its substantial mortality risk, particularly among vulnerable populations. This condition can lead to various complications, including sepsis, nutritional deficiencies, delays in growth and development, and, in severe cases, death. NEC not only impacts the health of the infant but also affects the emotional well-being and bonding experiences of parents. Despite advancements in neonatal care, the rate of NEC has increased, highlighting the need …

Philosophical System Of General T-Continuity As The Base Of Culture-Space Economics, Victor L. Tonn

Faculty and Staff - Articles & Papers

This paper presents a holistic philosophical system based on systric forms, operational transformors, and T-Continuity, aiming to establish cultural foundations for Type I and II Economies. Culture-space economics bridges Earth and space, initiating universal economics for the Great Space Era. The Comprehensive Universe (『SELF』) comprises three systems supporting mutual-central, micro-private, and macro-collective economies. Humanity’s spaceward journey advances T-Continuity, with human creativity—not just technology—as the primary driver, offering hope for cosmic peace through ideal cultural-spatial economies. This paper presents a holistic philosophical system based on systric forms, operational transformors, and T-Continuity, aiming to establish cultural foundations for Type I and II …

Strafford County 2025 Annual Report Of The Commissioners, Treasurer, Other County Officers, And The Strafford County Delegation For The Year Ending December 31, 2025, Strafford County Representatives

Strafford County, NH Annual Reports

This is an annual report for 2025 containing vital statistics for Strafford County in the state of New Hampshire.

Caring For The Commons: Craft Against Plastic, Cecilia Saez

Graduate Student Portfolios, Professional Papers, and Capstone Projects

My aim in this Civic Engagement Project (CEP hereafter) is twofold. On the one hand, it has been an attempt to explore theoretically the contradiction between individual action and its (oftentimes non-existent) effects on the large scale of things (on a societal and environmental level). I looked at how this tension plays out on a practical level, attending particularly to the issue of single-use plastic pollution. In this regard, the project unfolded in the following practical way:  I organized and lead two workshops in which participants create reusable tote bags from old t-shirts, encouraging them to reduce reliance on single-use …

Spiritual Ecology For Entanglement: Reshaping Perceptions Through Spirituality, Education, And Enchantment, Hannah M. Bregman

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Examining The Relation Between Cognitive Reflection And Directional Reasoning In The Context Of Political Affiliation, Ian Dargitz

West Chester University Graduate Theses, Dissertations, and Final Projects

The intent of the study was to examine contributing factors to political bias, in particular the role of cognitive reflection. I hypothesized that in an explicitly partisan context, cognitive reflection would be predictive of greater bias.

Participants completed the cognitive reflection test (CRT). They then read a prompt claiming that people with either conservative or liberal beliefs tended to score higher on the CRT, using either explicitly partisan (e.g., "Medicare for All") or relatively neutral language (e.g., "low-cost health insurance.") After reading this prompt, they were asked whether they believe the CRT is a valid measure of reflective ability. Participants …

Arts Enriched Head Start Preschool And School Readiness: Are Benefits Accentuated For Children Facing Greater Economic Hardship?, Isabella Capera

West Chester University Graduate Theses, Dissertations, and Final Projects

Children growing up in impoverished and low-income households face opportunity gaps that limit their school readiness (Blair & Raver, 2015). Head Start preschool, which serves families facing economic hardship, has been demonstrated to reduce these gaps and enhance school readiness. Further, multiple studies have suggested that arts enriched Head Start may offer particular benefits (e.g., Brown et al., 2010, 2018; Lobo & Winsler, 2008). Yet research to date is limited and has not examined whether the benefits of arts enriched preschool may be uniquely helpful for children facing the greatest economic risk. The present study examines growth in school readiness …

In Re: Social Media Adolescent Addiction/Personal Injury Products Liability Litigation, Northern District Of California

Historical and Topical Legal Documents

No abstract provided.

Practical Strategies For Instructional Faculty And Librarians Designing Accessible Instructional Materials, Rachel E. Trnka

Faculty Scholarship and Creative Works

While discussions of the accessibility of instructional materials are not new, librarians and instructional faculty are facing increased pressure to ensure the accessibility of their materials in the wake of the COVID-19 pandemic’s rapid shift to online education. Many faculty and librarians, however, do not receive adequate training and support in the area of accessible design. In addition, there is often confusion about who is responsible for ensuring the accessibility of instructional materials in higher education environments. This paper presents practical strategies for librarians and instructional faculty to identify readily available resources, create inventories of their own instructional materials, identify …

An Indigenous Sovereign Approach: Developmental Strategies And Guidelines For The Berger-Patawomeck Preserve Trail Network, Lauren N. Usher

Master of Urban and Regional Planning Capstone Projects

This planning document serves the Patawomeck Tribe's cultural, environmental, and sovereign needs by providing research and recommendations to sustainably steward ancestral lands through integrated Indigenous and Western practices. The plan adapts sustainable design strategies to guide trail maintenance and activities within the Berger-Patawomeck Preserve, examining Traditional Ecological Knowledge (TEK) alongside Western practices. A decolonized, sovereign lens guided the mixed research methods drawing on legal, regulatory, planning, and ethical frameworks to strengthen tribal health, education, and sovereignty. The research explores local ecology, Indigenous culture, and implementational strategies. The ecological findings document the Preserve's sensitive resources, including the Coastal Piedmont transition zone, …

Mixed-Methods Evaluation Of A Therapeutic Assessment Clinic Model For Children With Prenatal Alcohol And Substance Exposures, Lauren Perovsek

Clinical Psychology Dissertations

Prenatal alcohol and/or substance exposure (PA/SE) affects an estimated 6% to 23% of the U.S. population and is associated with complex neurodevelopmental profiles impacting cognitive, adaptive, and behavioral domains. Children with PA/SE frequently experience co-occurring early adversity, face significant diagnostic complexity, and encounter challenging systems of care. This often leads to individuals with PA/SE and their caregivers navigating substantial barriers to care, including stigmatizing experiences and fragmented service systems. The Specialized Neurodevelopmental Assessment and Consultation Service (SNACS) clinic addresses these needs through an FASD-informed model that integrates therapeutic assessment techniques within a brief, multi-session evaluation process. While prior research has …