Digital Commons Network^™

Ai, Experimental-Based Discovery And Preclinical Ind-Enabling Studies Of Selective Bmx Kinase Inhibitors For Development Of Cancer Therapeutics, Rwan Wael Elsanhoury

Selected Full-Text Dissertations 2020-

The current work aims to design and provide a preliminary IND-enabling study of selective BMX inhibitors for cancer therapeutics development. BMX is an emerging target, more notably in oncological and immunological diseases. In this work, we have employed a predictive AI-based platform to design the selective inhibitors considering the novelty, IP prior protection, and drug-likeness properties. Furthermore, selected top candidates from the initial iteration of the design were synthesized and chemically characterized utilizing 1H NMR and LC-MS. Employing a panel of biochemical (enzymatic) and cancer cell lines, the selected molecules were tested against these assays. In addition, we used artificial …

Development Of A Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model For Beta-Lactam Antibiotic Combination Against Enterococcus Faecalis Based On Time-Kill Assays To Predict Drug Disposition And Guide Dosing Strategy In A Severe Renal Impairment Population, Ruhma Zia Khan

Selected Full-Text Dissertations 2020-

Bacterial resistance to antibiotics continues to be a global health problem, limiting antibacterial therapy against infective endocarditis caused by Enterococcus faecalis. To overcome increasing resistance, dual beta-lactam therapy has been advocated as an alternative regimen for treatment – the synergistic activity against E. faecalis demonstrated to be effective. Currently, ampicillin plus ceftriaxone is the standard of care, but the practical application of this therapy is limited by ampicillin’s poor stability in solution at room temperature. A synergistic combination of penicillin plus ceftriaxone shows promise due to penicillin’s superior stability at ambient temperature, but ceftriaxone’s potential to cause hepatoxicity further limits …

Factors Affecting Detection Of A Cryptic Ambush Predator Using Camera Traps, With Implications For Snake Monitoring, Sarah Elizabeth Ebert

Theses, Dissertations and Capstones

Camera traps are becoming increasingly popular in wildlife research because they can be deployed for long time periods with little maintenance and are much less invasive than traditional trapping methods. However, they are primarily used to study large mammals and have not been extensively tested for snake species, many of which are cryptic and understudied. The Adapted-Hunt Drift Fence Technique (AHDriFT) arrays were designed to improve detection of herpetofauna by attaching camera traps to drift fences. In the summer of 2022, we installed 20 AHDriFT arrays at the Marine Corps Recruit Depot Parris Island in coastal South Carolina where we …

Prescriptive Behaviors: Tracking The Social Impact Of Film Portrayals Of Black Men, Garfield Ronald Benjamin

Theses and Dissertations

Cinematic and televisual media express the thoughts and emotions of people and cultures with the potential of unifying people through the social realities that are created around the visuals, narratives, and on-screen interpersonal interactions. Through media like film, television, and short-form online video, people interact with others in ways that, because of barriers like physical distance and/or social structures, they may not be able to in real life. The images, sounds, and stories depict their own realities, which are consumed, interpreted, and understood by viewers and can inform their perceptions and interpersonal interactions. Stuart Hall, Jamaican-British, cultural theorist, and political …

Climate, Energy, Economy: Interconnected Perspectives From Politics, Business, And The Public, Isabella Harper Heinzen

Theses and Dissertations

When considering the economic and social costs and benefits of a global, intergenerational, and environmental issue, rigid analysis often falls short. The topics discussed in this thesis aim to address the complex moral, economic, and political concerns regarding climate change to provide a holistic view of the issue and the role humans play. The first section on the scientific consensus addresses concerns regarding the existence and severity of climate change, finding where the responsibility lies for humans. The second section analyzes the energy context in modern society to understand the call for a transition from oil and gas to renewable …

Applying Groupthink To Digital Spaces: The Rise Of Online Conspiracy Theory Networks, Lily Karen Schow

Theses and Dissertations

This thesis examines the transformation of political paranoia and collective decision-making in the United States from the twentieth century to the digital age. Building on Richard Hofstadter’s concept of the “paranoid style” and Irving Janis’s theory of groupthink, it argues that the dynamics of conspiratorial thinking and collective misjudgment have not disappeared but have been reconfigured by digital communication systems. While Hofstadter identified paranoia as a recurring rhetorical mode and Janis analyzed groupthink as a pathology of small, cohesive decision-making groups, this study contends that both frameworks require adaptation to account for contemporary digital environments. The analysis traces how historical …

The Heretical Church: A Comparative Analysis Between The Gospel Of Thomas And The Gospel Of John, Isabella R. Moore

Theses and Dissertations

This thesis uses a comparative analysis between the allegedly “heretical” Gospel of Thomas and its canonical counterpart, the Gospel of John, to conduct a critique of the contemporary Catholic Church. This analysis and critique also utilize evaluations of medieval and modern definitions of heresy within a religious context, as well as a comparison between bishop dissent of these “secret” or “gnostic” gospels in the 3rd, 4th, and 5th centuries and papal dissent in the 21st century. After conducting the comparative analysis between the two gospels, I posit that the Church’s charge of heresy toward the Gospel of Thomas is an …

Human Being And Being Human In Frankenstein Through The Lens Of Catholic Social Teaching, Faria S. Sookdeo

Theses and Dissertations

This dissertation argues that looking at social issues, such as racism, adverse effects of advancement in and use of science and technology, and environmental concerns, in Mary Shelley’s Frankenstein through a Catholic Social Teaching (CST) lens enables an understanding of the nature of humans that brings marginalized and non-marginalized creatures, both human and non-human in a common community and emphasizes and that our behaviors towards such creations are what define our humanity and are vital to the preservation of our environment, subjects that are as relevant today as they were when Shelley first published Frankenstein in 1818 and when the …

Using High Speed Kinematics To Investigate Kinematic Variation Across Populations Of Astyanax Mexicanus, Agniva Sinha

Theses and Dissertations

Kinematic analysis pipelines now provide temporal and geometric resolution for determining a variety of body movement. These machine-learning trained programs allow behavioral neuroscientists to dissect complex behaviors and relate changes in those movements to conserved neural assemblages. These analyses are common in model organisms, but a lack of ethologically driven kinematic work in non-models has hampered our understanding of how evolution shapes behavior through sensorimotor circuits. Astyanax Mexicanus is a unique model organism that allows us to understand how evolutionary divergence as a result of adaptation to environmental conditions leads to genotypic and associated phenotypic changes in brain development and …

The Impact Of Music Education On Language Acquisition Of English Language Learners, Andrew David Frey-Gould

Theses and Dissertations

Schools continue to face increasing accountability pressures to improve English language proficiency outcomes for English Language Learners (ELLs), while access to arts education, particularly music, has declined in many districts. This study examines whether music education can serve as an effective and equitable support for language development among elementary ELL students. The purpose of this causal-comparative study was to determine whether participation in ensemble-based music programs (i.e., band, orchestra, and chorus) is associated with greater gains in English language proficiency than participation in compulsory general music instruction. This study is grounded in Krashen’s Second Language Acquisition theory and Patel’s resource-sharing …

Prevention Of Inflammation-Associated Neurodegeneration: Assessing The Efficacy Of N,N-Dimethylacetamide (Dma) In Lipopolysaccharide (Lps)-Induced Neuroinflammation Using C57bl/6 Mice, Teeshavi Devi Acosta

Theses and Dissertations

Neurological function is closely linked to both longevity and quality of life. While some degree of neurodegeneration occurs naturally with aging, pathological neurodegeneration leads to devastating functional decline. The mechanisms underlying these processes remain incompletely understood; however, neuroinflammation is recognized as a key driver of neuronal dysfunction and death. Emerging evidence indicates that neuroinflammatory cascades can precede and potentiate hallmark features of neurodegenerative diseases, including synaptic loss and cognitive decline observed in Alzheimer’s disease (AD). Activation of the NF-κB signaling pathway contributes to amyloid beta (Aβ) peptide production, further amplifying a cycle of inflammation and neuronal injury. Preclinical work from …

2026-2027 Catalog, Governors State University

Catalogs

The 2026-2027 Governors State University Undergraduate and Graduate Catalog is a comprehensive listing of current information regarding:
Degree Requirements
Course Offerings
Undergraduate and Graduate Rules and Regulations

Effectiveness Of Walleye Stocking In Winter Kill Lakes, Tyler Haus

Journal of Earth and Life Science

Winter kill events, marked by extensive fish mortality due to hypoxic conditions under the ice, are a common phenomenon in shallow eutrophic lakes, especially in the northern lakes in the northern United States. These events can drastically alter fish communities and often result in the elimination of top predators. Though these lakes will typically slowly bounce back to what they were in a couple of years. This study evaluates the effectiveness of walleye, Sander vitreus, stocking in lakes after a winter kill. For this study, four known winter kill lakes that are consistently stocked with walleye were studied. Pre- …

Assessing Urban–Rural Differences In Largemouth Bass Abundance In Minnesota, Jonathan Gates

Journal of Earth and Life Science

Urbanization can significantly alter freshwater ecosystems and influence sport fish populations. This study examined differences in largemouth bass Micropterus nigricans catch-per-unit-effort (CPUE) between urban and rural lakes in Minnesota and evaluated temporal changes between 2000–2010 and 2011–2021. Forty lakes (20 urban, 20 rural) were selected using Minnesota Department of Natural Resources fisheries survey data. Lakes were classified using NLCD 2019 land cover data, with ≥10% developed land designated as urban. Nonparametric analyses (Wilcoxon rank-sum and signed-rank tests) were used to assess spatial and temporal differences in CPUE. Results showed that rural lakes had consistently higher median CPUE than urban lakes …

Statewide Northern Pike Response To Minnesota’S 2018 Regulation Change, Elijah Wozniak

Journal of Earth and Life Science

Management of northern pike (Esox lucius) is challenging because it attempts to balance ecological sustainability with angler interests. Northern pike often stunt their own growth by diminishing the size and abundance of prey fish, their food source. Anglers are often displeased when small pike occur in high population densities. In response to populations of small northern pike, the DNR implemented a new, statewide northern pike regulation in 2018. The objective of this study was to determine whether the regulation successfully changed the mean weight, length, and CPUE of northern pike in Minnesota. The secondary objective was to test …

Neonicotinoid Bioaccumulation In Bluegill And Bullhead Within Lake Julia And Lake Zumwalde, Jake Stuber

Journal of Earth and Life Science

Brown Bullhead Ameiurus nebulosus, Yellow Bullhead Ameiurus natalis, and Bluegill Lepomis macrochirus are unique in their stark differences. Bullhead are scaleless bottom feeders that can tolerate high pollution and low O₂ conditions. In contrast, Bluegill are scaled, aggressive nesters and are less tolerant of high pollutants or low-oxygen conditions. Among these pollutants include a class of chemicals called neonicotinoids (hereafter referred to as neonics). Neonics are a class of insecticides primarily used within agriculture and pest management. Due to the effectiveness, application has escalated on a global scale. They have been well documented by many toxicology assessments. …

Comparison Of Calcified Structures To Estimate Ages Of Northern Pike Esox Lucius In Various Lakes, Kaed Rauk

Journal of Earth and Life Science

Northern pike Esox lucius are a dominant predatory fish in many aquatic systems. They can have significant impacts on the ecosystems they inhabit and are also a popular game fish among anglers. However, northern pike are a difficult species to age accurately. This study aimed to compare calcified aging structures to identify trends and determine which structure provides the most accurate age estimates. A total of 119 northern pike were sampled, and multiple structures from each fish were independently aged by two readers. The coefficient of variation (CV) was calculated for each structure to assess precision. Sectioned sagittal otoliths exhibited …

Indigenous Land Seizure & Environmental Injustice: Impacts Of Settler Colonialism, Lydia Moorman

Journal of Earth and Life Science

The fields of conservation and environmentalism prioritize ecosystem health, yet both emerged from western frameworks that displaced and criminalized Indigenous land stewardship. The idealization of “pristine wilderness” narratives served to justify the removal of Indigenous peoples from their homelands and erased millennia of sustainable land stewardship that had maintained ecological balance long before western conservation existed. These narratives not only misrepresented Indigenous relationship with land but also constructed a false dichotomy between humans and nature that positioned Indigenous presence as a threat rather than a source of ecological knowledge. Simultaneously, anthropogenic expansion; such as pipelines, mining, railroads, and other extractive …

Size Structure Comparison Of Bluegill In Lakes With And Without Special Regulations, Jenna Lawin

Journal of Earth and Life Science

Lots of individuals have mixed feelings about special regulations for all sorts of game fish species such as northern pike Esox lucius, crappie Pomoxis spp., sunfish Lepomis spp., and so on. One species commonly sought after by many is bluegill Lepomis macrochirus. Bluegill are often deemed easy to find, catch, and clean. This study looks at three different categories of lakes (all lakes contain bluegill populations). The three categories are lakes with a five sunfish limit, lakes with a ten sunfish limit, and lakes without any special regulations. This study provides valuable insight into the size …

History And Tradition In First Amendment Intellectual Property Cases: A Critique, Rebecca Tushnet

Marquette Intellectual Property & Innovation Law Review

This Article examines the increasing reliance on "history and tradition" as a method of constitutional analysis in First Amendment cases involving intellectual property. The author argues that, although the Supreme Court has recently embraced this methodology in other constitutional contexts, particularly Second Amendment jurisprudence, it has long relied on similar reasoning to uphold intellectual property rights against First Amendment challenges. Through an analysis of cases involving the right of publicity, copyright, and trademark law, the Article contends that the Court has used historical analogies to justify expanding intellectual property protections while giving insufficient consideration to their impact on free expression. …

Not All Sunshine In Wisconsin: The Cloudy Public Disclosure Predicament Surrounding Trade Secrets, Amelia S. Murray

Marquette Intellectual Property & Innovation Law Review

This Comment will explore the current landscape surrounding trade secret protections in Wisconsin Open Records Law requests. The lack of access to state-protected trade secrets, and overall lack of transparency, effectively endangers the general health and safety of the Wisconsin public and environment. When a request is made for information under the Wisconsin Open Records Law pertaining to state information protected by trade secret, and the requester is denied access to such information due to its trade secrecy status, the state should have to disclose trade secret information if it poses a greater danger to environmental health, human health, or …

Primary Avian Tracheal Cell Models For The Isolation Of Emerging Avian Metapneumovirus Strains, Tricia Serrao

Electronic Theses and Dissertations

The emergence of avian metapneumovirus (aMPV) subgroups A and B in the United States poultry industry has created an urgent need for standardized, host-specific diagnostic platforms. Historically, reliance on continuous, multi-species cell lines has limited the primary isolation of field strains and introduced potential adaptation artifacts. To address these challenges, this research first established and characterized a reproducible primary cell culture system derived from the tracheal tissues of 1-day-old turkey poults. This system was maintained in an optimized DMEM/F-12 formulation supplemented with 5% FBS, EGF, and ITS, with early-passage cultures achieving 90% confluence within 24 to 48 hours. Morphological and …

Small Mammal Communities Within And Land Coverage Around Southwestern Missouri Prairies, Kaitlyn J. Bebensee

Graduate Theses/Dissertations

Land alterations can reduce the amount of suitable habitat necessary for persistence of an associated species. Within such constrained habitats, limited resources may elicit competition, which could cause shifts in abundance and occurrence of species. Missouri prairies have been declining in size, making it imperative to collect reference data on mammal populations within and land use types around remnants. For this study, I trapped small mammals in Southwestern Missouri prairies because they can be indicators of environmental health and can vary in abundance between prairies. I focus on the diet of two dominant small mammals, Peromyscus maniculatus and Microtus ochrogaster …

Gene Editing And The Accessibility Of Bioterrorism: Rethinking Global Biosecurity In The Post-Covid-19 Era, Nicholas Morales

Graduate Theses/Dissertations

COVID‑19 demonstrated how a single biological event can strain health systems, disrupt supply chains, undermine national security, and erode public trust. This shock occurred as biotechnology became dramatically more accessible: gene editing and synthetic biology tools once limited to specialized laboratories are now widely available through inexpensive equipment, open‑source data, and decentralized expertise.

This expanded access accelerates innovation but also broadens the threat landscape. The ability to reconstruct pathogens using publicly available sequences and mail‑order DNA shows that complex biological synthesis is no longer confined to state programs. These risks are amplified by opaque biotechnology activities in China, Russia, and …

Using 1:1 Behavior-Analytic Instruction To Enhance Outcomes Of A Social-Emotional Learning Curriculum: A Retrospective Single-Case Clinical Evaluation, Cierra Vandermeer

Graduate Theses/Dissertations

Social-Emotional Learning (SEL) is the process through which people acquire and apply skills to manage emotions, form relationships, make responsible decisions, and pursue personal and shared goals, and these competencies shape identity development and daily functioning (Collaborative for Academic, Social, and Emotional Learning [CASEL], 2020). While there are many SEL programs and curricula that exist for school-aged children, there are few curricula that a) have a focus on 1:1 instruction for preschool to primary-aged children, and b) integrate and incorporate Applied Behavior Analysis (ABA) principles. This thesis reviewed a retrospective case study of a six-year-old female-identifying student who participated in …

Perfluorooctane Sulfonate (Pfos)-Induced Disruption Of Mitochondrial Activity And Cell Adhesion In Liver Cells, Phuong Dam Nam Tran

Graduate Theses/Dissertations

Perfluorooctane sulfonate (PFOS) is a persistent environmental pollutant associated with potential hepatoxic effects and other health risks. Despite its widespread distribution, the mechanisms underlying its toxicities remain to be fully understood. To investigate PFOS toxicology, my study utilized HepG2 and THLE-2 human hepatic cell models to replicate conditions reflecting PFOS accumulation in the liver. Cell viability, cell stress, and cell death assays were conducted to assess the toxicological influence of the chemical on both cell lines. Total RNA extraction was performed, followed by cDNA sequencing, and RT-qPCR. The XTT viability assay revealed a dose-dependent decrease in number of viable cells …

Eastern Fox Squirrel (Sciurus Niger) Occupancy In A Southern Missouri Woodland, Daniel Garten

Graduate Theses/Dissertations

Species occupancy, which relates the probability of presence of a species at a specific place and time, is an important component of conservation and wildlife management. Principally it is used for estimation of a species’ distribution as well as understanding species interactions and quantifying environmental effects. The purpose of this study was to analyze occupancy of the Eastern Fox Squirrel (Sciurus niger) across multiple seasons (2019–2022) at Bull Shoals Field Station (BSFS), and to identify potential covariates associated with detection and colonization. Data were drawn from camera trap surveys from 26 sites during summer and fall seasons. Multi-season occupancy models …

The Underdiagnosis Of Neurodevelopmental Disorders In Women: Recognizing A Spectrum Of Symptoms, Taylor D. Bloomhuff

Psychology Doctoral Specialization Projects

Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) have long been viewed as predominantly male diagnoses. Based on foundational studies for these disorders, not only are they more prevalent in male children, but symptom severity is also higher in male children. In attention-deficit/hyperactivity disorder in particular, it has become a common assumption that hyperactive/impulsive and combined types are ‘male’ ADHD presentations, while the inattentive type corresponds to the few female children who meet diagnostic criteria. However, emerging research looking at the decrease in autism spectrum disorder and attention-deficit/hyperactivity disorder prevalence rates between gender in adulthood suggests that these neurodevelopmental disorders …

Urban Megaregions In The United States: A Gis-Based Approach To Defining A New Regional Geography, Jonas Rugys

West Chester University Graduate Theses, Dissertations, and Final Projects

This study investigates urban megaregions in the United States. The regional concept is examined from its origins in the geographic tradition as well as its transformation in the twentieth century to its current state. A GIS-based methodology for defining urban megaregions is presented and discussed. The results challenge existing assumptions of population and employment growth in the United States.

Edward J. Kelly Prize In Elder Law, Notre Dame Law School

Student, Faculty, and Staff Awards

The Elder Law Prize is intended to advance the study of elder law and to encourage and assist Notre Dame Law students who may have an interest in this field. This award is given annually to the NDLS student who has written the best essay, article, or legal brief on a topic relating to elder law. Due to a gift from the Retirement Research Foundation on behalf of Mr. Ed Kelly, the winner of the award will receive a monetary prize.