Digital Commons Network^™

Horizontal Gene Transfer And Reciprocal Chimerism In Compactonostoc (Nostocales, Cyanobacteriophyta) With Evidence For Two New Species In The Genus., Daniel Al Fatayri

Masters Essays

The genus Nostoc has long been known to be polyphyletic, and recent taxonomic work has segregated several Nostoc-like lineages into new genera, including Compactonostoc. Until now, Compactonostoc shennongjiaensis was the only described species in the genus. In a survey of biological soil crusts from Santa Catalina Island (California, USA), we isolated two Nostoc- like strains that phylogenetically affiliate with Compactonostoc. A polyphasic approach based on morphology, 16S rRNA gene phylogeny, 16S–23S ITS secondary structure, and cloned ribosomal operons revealed that each strain harbors two highly divergent ribosomal operon types. One operon (Type 2) is closely related to C. shennongjiaensis and …

Comparative Analysis Of Serum-Free Culture Conditions On Cell Proliferation And Extracellular Vesicle Production By Adipose-Derived Stem Cells, Ayna Ghulldu

Honors Undergraduate Theses

Adipose-derived stem cells (ADSCs) are promising candidates in regenerative medicine due to their proliferative capacity, self-renewal, and secretion of extracellular vesicles (EVs) that mediate intercellular communication. Serum-free media has been increasingly explored for MSC culture as it eliminates xenogeneic components, improving human therapeutic suitability. However, comparative evaluation of distinct serum-free formulations on ADSC proliferation and EV output simultaneously remains limited. This study compares a serum-containing medium to three proprietary serum-free media prototypes differing in composition, including the presence or absence of extracellular matrix proteins, to inform the optimization of culture conditions for clinical use. Proliferation, EV characteristics, and gene expression …

The Depuration Of Microplastic Pollution In Aquacultured Indian River Lagoon Oysters, Lee Nguyen

Honors Undergraduate Theses

Plastics are widely used in consumer goods and industrial manufacturing, and their degradation into microplastics (MP, size < 5 mm) has created an emergent environmental pollutant. Plastics readily enter aquatic environments, where they accumulate additional contaminants and bioaccumulate in organisms. While MP contamination in marine ecosystems is well documented, less is known about MP presence in aquacultured shellfish. Depuration, the process of purging contaminants from shellfish, is conducted in sterile seawater without food, which may cause oyster starvation and death. To date, MP depuration has not been examined in the aquacultured eastern oyster (Crassostrea virginica) in published studies. This study had 3 goals: 1) evaluate the effects of algal feed on oyster survival during depuration, 2) determine the effect of algal feed on depuration effectiveness, and 3) investigate the effect of a ten-day depuration on MP concentration in aquacultured C. virginica soft tissue. MP were quantified in oyster tissues, biodeposits, and in industrial algal feed. Tissues were digested using alkaline solutions, manually examined via microscopy, and analyzed using Fourier-Transform Infrared Spectroscopy (FTIR) to investigate MP polymer …

The Impact Of Gastric Sleeve And Roux-En-Y Gastric Bypass On Chief Cell Function And Protein Digestion In Obese Patients, Garikoitz Mikel Gainza

Honors Undergraduate Theses

Obesity has become one of the largest global health concerns of the 21^st century, correlating with numerous associated diseases. To help address the growing prevalence and burden of obesity, sleeve gastrectomy and Roux-en-Y gastric bypass have become two commonly performed surgical procedures done to promote weight loss by altering the anatomical structure of the stomach and surrounding organs of the gastrointestinal system. Although the benefits of improved metabolism linked to these surgical procedures are well studied, their impact on the physiology of gastric cells, and more specifically chief cells as they relate to protein digestion post-surgery, is yet to …

Guideline For A Burnout Bundle For Nurses In Psychiatric Mental Health Units, Festus Irabor

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Abstract

Problem: Burnout among nurses, especially in psychiatric mental health units, significantly impacts both their well-being and the quality of patient care. Despite its severity, with approximately 30% of nurses worldwide affected and contributing to a 31.5% nurse turnover rate (Ge et al., 2023), there are limited formal guidelines specifically targeting nurse burnout prevention in the mental health setting. The issue is particularly acute in the United States, where 91.1% of psychiatric nurses report experiencing burnout, compared to 79.9% of other healthcare professionals (Anger et al., 2024). In the local unit 38.05% have experienced burnout.

Purpose: The PICOTS for this …

Noninvasive Monitoring Techniques: The Use Of Scat-Sourced Dna And Camera Traps To Monitor Mammalian Carnivore Species At The Ucf Arboretum, Zachary Montealegre

Honors Undergraduate Theses

The 800-acre University of Central Florida Arboretum Natural Lands functions as a conservation area, recreational space, and research site, making it essential to understand the ecological community it supports. Traditional wildlife monitoring methods such as mark-recapture and blood sampling can be effective but may stress animals or disrupt natural behaviors. To minimize these impacts, this study used non-invasive techniques, specifically scat-based DNA analysis and camera trapping, to assess carnivore species' presence. Two ecologically similar sites within the Arboretum were selected. Suspected carnivore scat was collected twice weekly over two months using both structured and opportunistic sampling. DNA was extracted, amplified, …

Two Dogmas Of Free Speech Doctrine, David R. Dow

Oklahoma Law Review

No abstract provided.

A Preemptive Strike Against The Misinterpretation Of The 2023 Amendment To Federal Rule Of Evidence 702(D): The Importance Of Preserving The Requirement For A Showing That The Expert Has Properly Applied His Or Her Methodology, Edward J. Imwinkelried

Oklahoma Law Review

No abstract provided.

Sedimentology, Paleontology, And Depositional Environments Of The Upper Devonian Lock Haven Formation In West Burlington Quarry, North-Central Pa, Michael Harman

Honors Theses

The Upper Devonian Lock Haven Formation in north-central Pennsylvania preserves evidence of significant climactic and evolutionary transitions, including the fin-to-limb transition and initial arborescence. The formation contains abundant sedimentary features, palynomorphs, trace fossils, and fish body fossils, making it crucial for reconstructing these paleoenvironments. However, integrated studies on the Lock Haven Formation are rare. This study characterizes the depositional environments, ichnology, paleontology, and age of the Lock Haven Formation. A recent exposure at the Insinger-Ward West Burlington Quarry reveals three middle to early late Famennian lithofacies associations (FAs). FA1 consists of red sandstone, shale, and mudstone containing rhizoliths (deeply penetrating …

Origins Of Musical Preferences: Infants' Responses To Sung Vocal Timbre, Hayley Leopold

Honors Theses

Understanding the origins of aesthetic preferences remains an important question in psychology, particularly in domains such as music where both biological constraints and cultural learning play important roles. While adults exhibit consistent preferences for certain musical features, including aspects of vocal quality or timbre, it remains unclear whether these preferences reflect early-developing perceptual biases or emerge through experience. The present study addresses this question by adopting a developmental paradigm previously used in the visual domain to examine whether infants’ responses to music align with adult aesthetic evaluations.

Twenty three infants between 8 and 12 months of age participated in a …

Paleoflood Chronology For The West Branch Of The Susquehanna River Using Abandoned Chute Channel Sediments, Pennsylvania, Usa, Juliette A. Vanluven

Honors Theses

Anthropogenic climate change is altering the hydrologic cycle, increasing flood frequency and severity, with associated increased risks in population exposure. This is associated with increasing risks to the population of the Susquehanna River Valley, which supports over 600,000 people today. However, our understanding of the frequencies of large floods is limited by relatively short instrumental records. By studying sediments from an abandoned chute channel in the Robert Allen Natural Area near Williamsport, PA, we can extend the existing flood records using paleoflood slackwater sediments along the West Branch of the Susquehanna River.  Sylvan Dell is an abandoned chute channel that …

Predators And Precedents: Grizzly Bears, Joe Pickett, And The Law Of Delisting, Temple Stoellinger, Kelly Dunning, David Willms, Arthur Middleton, Bethany Aragon

Wyoming Law Review

When a grizzly bear kills a fisherman in C.J. Box’s Three-Inch Teeth, the attack occurs in Wyoming’s Bighorn Mountains—territory where bears “weren’t supposed to be.” This fictional scenario reflects a real dilemma: grizzly bears have recovered so successfully that they now roam beyond designated recovery zones, yet federal delisting efforts have repeatedly failed, caught between contested science and competing narratives about connectivity requirements, ESA policies, federal authority, state and local control, and the prospects for coexistence with apex other predators.

This Article examines how popular culture, legal frameworks, and conservation science intersect to shape wildlife policy. Box’s novel— mixing …

Evaluating The Use Of Precision Technology To Understand Differences Between Ketotic And Non-Ketotic Jersey Cows, Emily Kathryn Palermo

Honors Theses and Capstones

No abstract provided.

Tmem116 Crispr-Mediated Knockout Prevents Proper Lens Regeneration In Iberian-Ribbed Newts, Damien T. Mann

Honors Theses and Capstones

Eye diseases like cataracts, age-related macular degeneration (AMD), and glaucoma are widespread and detrimental conditions affecting many people across the globe. While there are reliable and successful treatments for those with cataracts that can reverse vision impediments, others like glaucoma and AMD have limited treatment options. Additionally, eye damage resulting from these conditions is commonly irreversible, establishing a need for new treatment options. The Iberian-ribbed newt, Pleurodeles waltl, is a salamander species primarily studied for their amazing regenerative capabilities. Particularly, these newts are capable of de novo lens regeneration after a complete resection, providing a unique opportunity to study regeneration …

Faith, Formation, And Formalization: Entrepreneurship Development Among Women In Ghana, Patricia Adams-Williams

Doctor of Ministry

The problem addressed in this study is the absence of a unified, faith-centered framework that equips single mothers in Ghana to build sustainable livelihoods while strengthening their spiritual identity. Although Ghanaian women demonstrate remarkable resilience and entrepreneurial drive, many remain confined to informal markets without access to business training, mentorship, or systems that connect their work to their calling. This dissertation argues that integrating spiritual formation with entrepreneurship training creates a pathway for lasting transformation. The thesis of this study is that Kingdom-centered entrepreneurship, rooted in biblical identity and supported by communal mentorship, empowers women to move from survival to …

Anuran Occupancy Of Created Wetlands Within Reforested Legacy Surface Mines In Kentucky And West Virginia, Jillian C. Newman, Steve Price, Jacquelyn C. Guzy, Joshua Castle, John J. Cox, Jeffery L. Larkin, Christopher D. Barton

Forestry and Natural Resources Faculty Publications

Restoration of habitat is an important component of wildlife management. Surface coal mining has altered forest cover in the Central Appalachians, and most reclamation activities on previously mined lands result in non-native grasslands or shrub lands. The Forestry Reclamation Approach (FRA), which emphasizes non-native vegetation removal, soil decompaction, planting of native trees and shrubs, and, in some cases, wetland creation represents an alternative to grassland-based reclamation that may promote forest-associated wildlife on legacy surface mines. We used automated recording units to evaluate the response of anurans to created wetlands and the FRA in Kentucky and West Virginia, USA. We used …

Male Disposability, Law, And Feminism, Edward Cantu

Faculty Works

This article explores scientific evidence that societies care more about the welfare and safety of females than that of males, and that this dynamic of "male disposability" is deeply entrenched in culture, and thus in law. The recognition and integration of male disposability theory would mean an evolutionary leap in modern theorizing about gender and the law, but it is ignored. Why? Feminist theory dominates current academic gender discourse. Far from appreciating the explanatory power of male disposability theory, feminist theorists are often invested in theorizing gendered problems in ways that mischannel compassion away from men and toward women. The …

The Federal Rules Of Evi-Dance: Exploring And Reimagining Evidence Law Through Music, And Proposing Amendments To Rule 604, Brian C. Potts

Suffolk Journal of Trial and Appellate Advocacy

No abstract provided.

Microglial Apoe Across Alzheimer’S Disease-Relevant Pathologies, Georgia Nolt

Theses and Dissertations--Physiology

APOE exists as three common alleles (APOE2, APOE3, APOE4) that encode their corresponding protein isoforms (apoE2, apoE3, apoE4). Despite differing by only one or two single-amino acid substitutions, each APOE allele confers a distinct AD risk profile with APOE4 increasing risk by 28% and APOE2 decreasing risk by 14% compared to the most commonly expressed APOE3 allele. While traditionally considered “neutral,” APOE3 still accounts for ~36% of AD cases while APOE4 contributes ~57%, indicating that the majority of AD cases would not occur in the absence of the APOE3 and APOE4 alleles. Microglia, the resident phagocytic immune cells …

Investigating Sex Differences In The Regulation Of Conditioned Morphine Reward By Orexin, Farzana Akter Koly

Psychology Theses

Strong activation of the brain’s reward circuitry by morphine and morphine-associated cues drives the progression toward morphine abuse. Additionally, orexin neurons in the lateral hypothalamus (LH) are activated in response to cues paired with morphine reward. The orexin system, particularly the orexin-1 receptor (OX1R) regulates reward-seeking behavior through its activation. Despite the well-established role of orexins in reward-related behaviors, the specific contribution of OX1R in morphine-associated reward remains unclear. Furthermore, while sex differences in drug reward and reward-related behaviors are well documented, they remain unexplored in the regulation of morphine-associated reward by orexins. To address this gap, the present study …

Characterizing Gut Microbial Communities And Symbiont-Mediated Detoxification In Herbivorous Insects, Rachel C. Vargas

Biology Dissertations

Insect gut bacteria are vital contributors to host physiology, yet the broader prevalence and fitness implications of symbiont-mediated detoxification remain poorly understood. This thesis investigates these dynamics across three research chapters. Chapter 1 uses 16S rRNA sequencing to characterize how grasshopper gut microbial communities vary across species, dietary breadths, and gastrointestinal segments. Chapter 2 evaluates the detoxification capacity of over 150 bacterial isolates from diverse herbivores against the plant allelochemicals phenethyl isothiocyanate, rutin, and chlorogenic acid to determine if host dietary specialization predicts microbial metabolic ability. Finally, Chapter 3 employs fitness bioassays to test whether inoculating generalist herbivores with detoxifying …

American Elderberry's Next Top Pollinator: Evaluating The Role Of Arthropods In Pollination, Jenny K. Burrow

Graduate Theses/Dissertations

American elderberry (Sambucus nigra subsp. canadensis) is a woody deciduous shrub native to eastern North America. In addition to its long history of use by indigenous peoples, there is renewed interest in cultivating and consuming American elderberry, primarily driven by expanding health supplement markets. Despite recent advances in horticultural development of American elderberry, its pollination ecology remains poorly understood. In this field study, I evaluated the contribution of arthropod visitors to pollination of American elderberry. To do this, I first characterized the identities and abundances of arthropod visitors via timed arthropod collections and floral observations during peak flowering …

2026 Oer Deep Dive, Caterina B. Azzarello, Cassendra Bergstrom, Kirsten Gilderhus

About OER

The Affordable & Open Educational Resources (AOER) Committee at UNC, in collaboration with the Colorado Department of Higher Education, UNC’s Center for the Enhancement of Teaching and Learning, and the University Libraries, hosted an in-person OER Deep Dive professional development workshop on Tuesday, May 19, 2026. This full-day event was created for faculty and staff interested in learning more about Open Educational Resources (OER) and exploring ways to incorporate them into their instructional practices.

Throughout the workshop, participants examined the foundations of OER, discussed distinctions between openly licensed and freely available materials, and explored the role of affordable course content …

A Transdisciplinary Approach To Advancing Water Security And Public Health: The “Nurse + Engineer” Model For Achieving Sustainability In Wash Systems Using Community-Based Participatory Research, Daniel B. Oerther, Sarah Oerther

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Human health is linked to the health of the environment, a concept referred to as planetary health. As environmental challenges become increasingly complex, single-disciplinary approaches are insufficient to achieve sustainable solutions. This article presents a transdisciplinary framework, termed the "Nurse + Engineer" model, as a novel methodology for addressing complex problems at the nexus of environmental engineering and public health. The model integrates the technical design and systems-level thinking of environmental engineering with the community-based, patient-centered care of nursing. This work details the key lessons learned from the retrospective application of this framework to a series of multi-year, community-based participatory …

Environmental Engineers Develop Solutions To Problems Of Planetary Health: The Legacy Of Professor P. Aarne Vesilind, Daniel B. Oerther

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The principal ethical obligation of the engineering profession, to "hold paramount the health, safety, and welfare of the public," has been challenged for decades. Professor P. Aarne Vesilind identified two primary deficiencies: an anthropocentric bias that values nature only instrumentally and the use of non-mandatory, aspirational language for environmental protection, which resulted in the exclusion of enforceable environmental canons. This paper argues that two recent developments provide a comprehensive response to Vesilind's recommendations for engineering ethics. First, the United States Bureau of Labor Statistics has redefined environmental engineering as "developing solutions to problems of planetary health." Second, Oerther proposed a …

Examining The Drivers, Consequences, And Depoliticization Strategies Of Greenhouse Gas Emission Polarization Among The American Public, Lauren Wilner

Environmental Studies Honors Theses

This thesis examines the politicization of greenhouse gas emissions within the American public, tracing its evolution from a consensus based scientific topic to a deeply polarized partisan issue. While early research established a clear link between greenhouse gases and global warming, the late 20th century saw a strategic rise in skepticism fueled by conservative think tanks, contrarian scientists, and industrial interests. This study analyzes the psychological mechanisms and media practices that have exacerbated this divide and decline in public environmental concern, which has resulted in negative social and environmental effects due to a slowed federal response to the climate crisis. …

Comprehending Levels Of Explainability And Ai Recommendations (Clear) Study Series, Virginia Sullivan

Dissertations

AI systems can offer a great deal to improve decision-making through efficiency and predictive accuracy due to their unique ability to rapidly analyze large amounts of data relevant to the decision. Yet many AI systems remain opaque, limiting users’ ability to evaluate outputs and leading to issues of mistrust or over-reliance. This dissertation investigates how varying levels of AI explainability affect trust, perceived reliability, understanding, and confidence, and identifies perceptual and behavioral indicators of over-reliance behavior in AI-assisted decision making scenarios. This dissertation is organized as a three-study series. The CLEAR survey study uses a mixed design to examine the …

Icipe Annual Report 2025, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Annual Reports

No abstract provided.

Optimized Nano-Bilosomes Loaded Ocular Insert As A Promising Approach For Boosting Voriconazole Ocular Bioavailability: In-Vitro, Microbiological, And In-Vivo Assessments, Eman Gomaa, Eman Gomaa

Nanotechnology Research Centre

The eye possesses numerous physiological barriers that significantly limit the absorption of administered drugs, as only < 5 % get through. These barriers restrict drug bioavailability, often necessitating multiple dosing, which can lead to poor patient compliance. The study goal is to efficiently incorporate Voriconazole (VRC), a widespectrum antifungal candidate with a short half-life, into stable, biocompatible, non-irritating bile salt nanoparticles (Bilosomes, BLOs) to enhance its ocular delivery. Bilosomes were prepared by the ethanol injection method. Experimental (33 ) Box–Behnken Design (BBD) was employed; the amount of bile salt, cholesterol, and span-60 were chosen as independent variables, while entrapment efficiency (EE%), cumulative VRC release (Q8h), particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were the dependent variables. The formula of optimization showed EE% (59.04 ± 1.88 %), cumulative release after 8 h (81.35 ± 0.69 %), PS (222.53 ± 2.04 nm), ZP (− 72.53 ± 1.75 mV), and PDI (0.225 ± 0.03). It was chemically characterized using DSC and FTIR. Its spherical arrangement was confirmed using TEM. For ophthalmic application, the optimized formula was included in ocular inserts to extend ocular residence time while minimizing dosing frequency. The optimal VRC-loaded bilosomal ocular insert met the acceptable physicochemical criteria, was sterilized using UV radiation for conducting microbiological assay, in-vivo study, and pharmacokinetic analysis. For safety evaluation, an eye irritation study and histopathological examination were conducted. The results confirmed its effectiveness as evidenced by a significantly larger inhibition zone and 8.39-fold enhancement in VRC bioavailability compared to its suspension. These findings support the potential of bilosomes-loaded ocular insert as an effective ocular delivery of VRC.

Off-Label Abuse: The Prosecution Of Individuals For Pesticide Crimes Under The Federal Insecticide, Fungicide, And Rodenticide Act, Joshua Ozymy, Melissa Jarrell Ozymy

Natural Resources Journal

When individuals commit pesticide crimes involving significant harm or culpable conduct, they may be prosecuted for criminal violations of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), but we have little knowledge of how individual offenders have been prosecuted historically for such crimes. Using content analysis of 2,728 environmental crime prosecutions resulting from U.S. EPA criminal investigations, 1983 to 2021, we select all cases of individuals prosecuted under FIFRA for our analysis. We find that 100 cases were adjudicated, resulting in 135 years of probation, 75 years of incarceration, and $4.2 million in monetary penalties assessed at sentencing. Of those …