Digital Commons Network^™

Translational Reading Frame Predicts The Pathogenicity Of C-Terminal Frameshift Deletions In Mecp2, Jacky Guy, Elena Hein, Beatrice Alexander-Howden, Timur Von Bock Und Polach, Tricia Mathieson, Benjamin P Kleinstiver, Huda Y Zoghbi, Adrian Bird

Duncan NRI Faculty and Staff Publications

Mutations in the MECP2 gene cause the severe neurological disorder Rett syndrome. A cluster of frameshift-causing C-terminal deletions (CTDs) removes ~100 amino acids and accounts for approximately 10% of RTT-causing mutations. Their pathogenicity is unexpected because this C-terminal domain is dispensable in mice. Analysis of pathogenic and benign human MECP2 variants reveals that some individuals with apparently typical CTDs do not develop Rett syndrome, confirming that C-terminal truncations are not intrinsically pathogenic. Using human sequence data and mouse models we show that pathogenicity results from a marked reduction in MeCP2 levels and depends on the presence of a proline proline …

Cigarette Smoke Induces Fasn-Dependent Fatty Acid Metabolic Rewiring To Drive Bladder Cancer Progression, Chandra Sekhar Amara, Danthasinghe Waduge Badrajee Piyarathna, Abu Hena Mostafa Kamal, Yuen San Chan, Karthik Reddy Kami Reddy, Chandra Shekar R Ambati, Mohammed Khurshidul Hassan, Pratik Shriwas, Tanmay Gandhi, Antrix Jain, Tanja Gangnus, Pooja Popli, Roshan Borkar, Sung Wook Kang, Silvia L Summers, Vasanta Putluri, Sandra L Grimm, Sharan Venkatesh, Ningxin Song, Erin H Seeley, Jenna Hedlich-Dwyer, Shu-Hsia Chen, Nupam P Mahajan, Abhinav K Jain, Lacey Elizabeth Dobrolecki, Gabrielle A Wells, Hugo Villanueva, Jenny Li, Xuefeng Liu, Roni J Bollag, Anna Malovannaya, Sung Yun Jung, Hyun-Sung Lee, Irfan A Asangani, Martha K Terris, Chad J Creighton, Leomar Y Ballester, Balasubramanyam Karanam, Suyu Liu, Minjae Lee, Rajeeva R Raju, M Minhaj Siddiqui, Livia S Eberlin, Ramakrishna Kommagani, Arun Sreekumar, Jianjun Gao, Nicolas L Young, H Courtney Hodges, Cristian Coarfa, Natalie R Gassman, Seth P Lerner, Yair Lotan, Nagireddy Putluri

Faculty, Staff and Students Publications

Cigarette smoke promotes bladder tumor growth by enhancing cancer cell survival and proliferation through smoke mediated carcinogens. FASN, a key enzyme in fatty acid synthesis, is dysregulated in many cancers and correlates with aggressive phenotypes. In this study, we demonstrate elevated fatty acid levels and FASN specifically in smokers with bladder cancer. Elevated FASN under smoke exposure imparted epigenetic alterations, particularly histone acetylation, impacts DNA repair and DNA-binding transcription factors which regulate metabolic pathways. Under cigarette smoke, bladder cancer cells undergo a metabolic shift, utilizing glutamine as a major carbon source through reductive carboxylation to fuel fatty acid biosynthesis via …

Vitamin D As A Candidate Host Susceptibility Factor In Sugar-Driven Oral Dysbiosis, Moldir Turaliyeva, Nuraly S. Akimbekov, Ilya Digel, Adil Y. Yerezhepov, Mohammed Razzaque

School of Medicine Publications

Introduction: Sugar-sweetened beverages (SSBs) represent a modifiable dietary factor that promotes oral dysbiosis by supplying fermentable sugars and generating low-pH conditions that favor acidogenic and acid-tolerant biofilms. Vitamin D plays a biologically significant role in oral host defense through regulation of the epithelial barrier, induction of antimicrobial peptides, immune modulation, inflammatory control, and mineral metabolism. However, the extent to which vitamin D modifies the SSB -oral microbiome -disease pathway in humans remains unclear.

Methods: This narrative-conceptual review employed structured evidence mapping. Relevant literature was identified through PubMed/MEDLINE, Scopus, and Web of Science Core Collection, with additional sources obtained via citation …

First Insular Record And Dna Barcoding Of Euscorpius Vailatii Tropea & Fet, 2015 From Trizonia Island (Fokida, Greece), Konstantinos Kalaentzis, Francesco Frigioni, Alexios Panagiotopoulos, Elias Tzoras, Styliani Minoudi, Alexandros Triantafyllidis

Euscorpius

Euscorpius vailatii Tropea & Fet, 2015 (Scorpiones: Euscorpiidae), originally described from Aitoloakarnania and Fokida (Greece), is herein reported from Trizonia Island in the Gulf of Corinth, representing the first insular record for the species. The examined specimens are consistent with the diagnostic morphology of E. vailatii. The first molecular data for the species are provided, based on both mainland and insular populations. Comparative analyses further highlight the distinctiveness of E. vailatii from geographically close congeners, while phylogenetic results indicate a sister-taxon relationship with E. erymanthius, supporting a Quaternary biogeographic history shaped by the evolution of the Gulf of …

Effects Of Microalgae Supplementation On Broiler Meat Quality, Antioxidant Status, And Fatty Acid Profile, Ebrar Filizoğlu, Özlem Karadağoğlu

The Thai Journal of Veterinary Medicine

This study aimed to evaluate the dose-dependent effects of dietary supplementation with Schizochytrium limacinum, a microalga rich in omega-3 fatty acids and bioactive compounds, on the fatty acid composition and antioxidant status of broiler breast meat, as well as its potential effects on growth performance, carcass characteristics, and meat quality. In a 42-day feeding trial, 192 day-old Ross-308 broiler chicks were randomly allocated to four dietary treatment groups (48 chicks per group): a control group fed the basal diet without S. limacinum supplementation (0 g/kg), and three treatment groups fed the basal diet supplemented with 0.25, 0.5, and 1 …

Enabling Asl Digital Communication Under Poor Internet Access, Swann Thantsin

Student Theses

Video conferencing degrades asymmetrically. When bandwidth falls, a hearing caller loses picture quality and keeps the conversation; a deaf and hard of hearing signer, whose language is carried entirely in the visual modality, loses the conversation. This thesis asks whether signed video reduced to the rates at which commercial platforms fail can be reconstructed at the receiver well enough to keep signing legible. A twostage reduction pipeline crops to the signer and transmits the face and hands at higher fidelity than their surroundings, achieving a reduction of approximately 99%; reconstruction uses a recurrent bottleneck mixer architecture, trained both conventionally and …

Information Resources Utilization, Organisational Culture And Motivation As Determinants Of Quality Service Delivery Of Researchers In Nigerian Institute For Trypanosomiasis Research, Kaduna State, Nigeria., Alegbeleye Gabriel Olubunmi, Ibrahim Awodi, Yemisi Tomilola Babalola

Library Philosophy and Practice (e-journal)

This study investigated the combined influence of information resources utilization, organizational culture, and motivation on quality service delivery in the Nigerian Institute for Trypanosomiasis Research (NITR), Kaduna State. The population comprised 206 researchers across the six research departments of NITR, and a total enumeration technique was employed to include all the researchers. Using a structured questionnaire, 172 valid responses were obtained representing an 83.5% response rate. Data were analyzed using descriptive and multiple regression statistics. Anchored on Uses and Gratification Theory of Information behavior, the Denison Organizational Culture Model, and Self-Determination Theory, the findings revealed that the independent variables jointly …

Bibliometric Analysis Of The Top 100 Most Cited Publications From Saudi Arabia Reveals The Predominance Of Medical Fields, Mahmoud Kandeel, Abdulla Al-Taher

Saudi Medical Journal

Objectives: To explore the citation impact, journals, international collaborations, trends of research topics and gain more visibility for the Saudi contribution to the global scientific landscape. Methods: This bibliometric study analyzes the top 100 cited publications affiliated with Saudi Arabia in Scopus, from inception to January 2026. The extracted bibliometric indicators include total citation metrics, sources, collaboration maps, and co-occurrence networks of keywords and collaborations. Results: The results indicate a strong predominance for medicine and health sciences as the subjects of the most prolific and significant number of citations. A substantial proportion of the most cited papers originates from major …

The Role Of Chimeric Antigen Receptor Regulatory T Cells In Promoting Immune Tolerance In Solid Organ Transplantation: Mechanisms And Therapeutic Potential, Maher S. Alwethaynani

Saudi Medical Journal

Solid organ transplantation (SOT) is a life-saving procedure for patients with end-stage organ failure; however, lifelong immunosuppressant use is needed to prevent allograft rejection. These drugs increase the risk of non-Hodgkin lymphoma, liver, kidney, and lung cancers, and heighten susceptibility to oncogenic viruses, including hepatitis B and Epstein-Barr virus. The usage of chimeric antigen receptor (CAR) regulatory T (Treg) cells is a promising approach to induce transplant tolerance while minimizing dependence on immunosuppressants. The CAR Tregs offer the potential to enhance graft survival and quality of life by reducing immunosuppressant-related morbidity and mortality. Despite remarkable progress in transplantation tolerance, challenges …

Meta-Analysis On The Effect Of Tai Chi Chuan On Human Biomechanics And Health From (2021–2025), Bijad S. Alqahtani, Husam A. Almalki

Saudi Medical Journal

Objective: Prior reviews emphasize overall health outcomes of Tai Chi Chuan (TCC) but rarely resolve the biomechanical intermediates (such as Center of Mass (CoM)–Center of Pressure (CoP) control, joint loading) that link practice to clinical function—knowledge that matters for balance, fall risk, and osteoarthritic knee load management. This systematic review and meta-analysis aim to test the null hypothesis that TCC produces no improvement versus comparators in (i) biomechanical stability indices (mediolateral/anterior–posterior CoM–CoP separation; COP Root Mean Square RMS) and (ii) related clinical functions (such as Time up and go (TUG), Berg balance scale (BBS), Western Ontario and McMaster Universities Osteoarthritis …

Developmental Dysplasia Of The Hip In Saudi Arabia And The Gulf Countries: A Genetic Systematic Review Study, Naif Z. Alrashdi, Ahmed M. Almansour, Azfar Jamal

Saudi Medical Journal

Objective: To describe the available research on genetic determinants with special emphasis on the developmental dysplasia of the hip (DDH), in Saudi Arabia and Gulf nations, with reference to the genetic variants, family trend, and environmental factors. Methods: The literature search was conducted in PubMed, Embase, Scopus, Web of Science, and the Saudi Digital Library and Google Scholar through a broad literature search since the beginning of the databases until 2023. Studies that conducted in Saudi Arabia or Gulf countries which evaluated the relationships of genetic factors in DDH were included. Case reports, conference abstracts, and studies that did not …

Exploring Translational Medical Research Progress In G20 Countries: 5-Year Study, Hana A. Alhumud, Fars K. Alanazi, Edward B. Devol

Saudi Medical Journal

Objectives: Biomedical research is crucial for advancing medical knowledge and improving public health. However, the research process is often disjointed and lacks seamless progression, leading to delays and missed opportunities. To address this, the concept of translational research has emerged, focusing on the smooth transition of research results to the next stage of inquiry. Methods: This study analyzed approximately 40,000 research publications from the Web of Science database to identify research activities associated with translational research. Publications from Group of 20 (G20) countries over the past 5 years were examined to explore patterns of research focus and progress in this …

Escherichia Coli Concentrations In Sand And Water At Tributary-Influenced Lake Michigan Beaches, Josie Elaine Kuhlman

Masters Theses

Contamination of public recreational water and sand is a human health concern, creating a management challenge for public health officials. Past research has shown that Escherichia coli can persist in sediment and can be washed into recreational water. Currently, beach monitoring practices only utilize E. coli concentrations in water samples to determine beach safety and do not consider potential exposure to sediment/sand concentrations. In this study, I investigated the relationship between E. coli concentrations in water and sand samples, which will aid public health officials in making more informed decisions about beach closures. I utilized culture-based measurements of E. coli …

Vocabulary Knowledge Within Young Children With Autism Spectrum Disorder, Hannah A. Lord

Masters Projects

Young children with Autism Spectrum Disorder (ASD) are consistently experiencing a “definitional gap”, where they are able to process vocabulary breadth within labeling but are unable to comprehend text due to the lack of vocabulary depth. The four week vocabulary unit titled “Our World in Words” is created to bridge the gap between vocabulary breadth and depth for first graders. Research in Dual Coding Theory and Cognitive Load Theory provides insight into the use of stable visual anchors with orthographic facilitation, which allows for the disregard of auditory processing, along with an overloaded cognitive load. This framework includes four important …

Methodologies For Encouraging Creative Expression Within The Curriculum, Ian D. Martzke

Masters Projects

Many students struggle to find creative expression within the school curriculum. Indeed, since the 1990s we have seen a rise in average IQ but a reduction in scores through the Torrance Test for Creative Thinking (TTCT) (Kim, 2011). In the course of this project several methodologies for creative problem solving will be described and several lessons will be described that will both explain and model these methodologies of creative problem solving. These lessons will utilize the creative process (Wallas, 1926) and be written to include student choice (Hogan et al. 2020) specifically, within the instructional framework known as Teaching for …

Indigenous Ontologies And Architecture, Reconstructing Interrelational Relationships, Arlene Garcia Guzman

McNair Summer Research Program

Contemporary architecture faces a growing pressure to respond to the socioecological crises with regard to the consequences of design that so often accept environmental systems as separate from the living. In contrast, many Native systems, often referred to as Traditional Knowledge (TK), comprehend cumulative, place-based bodies of knowledge that are developed through extended histories of interaction with specific environments. In this context, Traditional Knowledge encompasses resource use practices, sustainability, spirituality, and an emphasis on a relational worldview. It is characterized in such a framework that different layers of existence, such as humans, animals, plants, water, climate, and materials, are understood …

South Asian Literature In Focus: A Review Of Nation And Nationalism In South Asian Literature, Amine Oudghiri

Critical Humanities

This is a book review.

States Strip Local Governments Of Authority To Govern Causing Some Rural Communities To Suffer, Terence J. Centner

Kentucky Law Journal

No abstract provided.

The New Parens Patriae, Meredith Johnson Harbach

Kentucky Law Journal

No abstract provided.

Against First Amendment Traditionalism, Jacob M. Schriner-Briggs

Kentucky Law Journal

No abstract provided.

Centering As Contemplative Inquiry And Practice: Teaching, Learning, And Living In The Anthropocene, Jennifer L. Schneider

Journal of Contemplative and Holistic Education

The Anthropocene may be an inescapable trap—one unwittingly shaped by human ways of relating to self, others, and the more-than-human world. While dominant discourses surrounding this epoch often evoke fear, apocalypse, or blame, how might it also invite us, as humans, into an opportunity for more holistic and contemplative education. This paper explores “centering,” a contemplative concept and practice introduced by curriculum theorist James Macdonald (1995), as a regenerative way of engaging with the Anthropocene through lived experience. Drawing from research on a graduate-level place-based course and an arts-based, pragmatic inquiry, I explore how centering can foster attunement to place, …

Anatomy Of Success: Unveiling Key Resources For A Stand-Alone Occupational Therapy Anatomy Course, Annika Knuth, Sophia Wilkes, Julia Huber, Graci Leineberg, Rebecca Ozelie

Student Journal of Occupational Therapy

Anatomy is a complex curriculum involved in occupational therapy education. This study aimed to investigate occupational therapy (OT) students’ perceived usefulness of resources offered in a stand-alone anatomy course within their program. A survey was administered to 284 OT students enrolled in accredited programs who had completed a stand-alone anatomy course. The survey assessed the resources available, their usage, and the perceived benefit to students' learning. Results indicated that open labs and teaching assistants were perceived as the most valuable resources for student success, while print/electronic textbooks and office hours were perceived as the least beneficial. These findings suggest that …

Transcriptomic Profiling Of The Donkey Endometrium Reveals Dynamic Molecular Transitions Across The Estrous Cycle, Limeng Shi, Shuaishuai Wu, Mingyue Zhao, Wenhao Zhou, Abd Ullah, Muhammmad F. Akhtar, Changfa Wang, Muhammad Z. Khan, Ying Han

The Thai Journal of Veterinary Medicine

The endometrium undergoes extensive cyclical remodeling essential for reproductive success; however, the molecular mechanisms governing these processes in donkeys (Equus asinus) remain poorly characterized. To address this gap, we performed high-throughput RNA sequencing on endometrial tissues collected from Dezhou donkeys (n = 16) at four post-ovulation stages: Day 0 (ovulation), Day 3 (early luteal), Day 7 (mid-luteal), and Day 18 (late luteal/pre-luteolysis). Differential gene expression analysis, Gene Ontology enrichment, and KEGG pathway mapping were conducted to characterize temporal transcriptomic dynamics. We identified 2,474, 6,548, and 1,288 differentially expressed genes in Day 0 versus Day 3, Day 0 versus …

Adaptive Phishing Url Detection Using Hybrid Fuzzy C-Means Clustering And Xgboost, Muntadher Mohammed Kareem, Rawaa I. Farhan

Karbala International Journal of Modern Science

Phishing attacks continue to evolve in sophistication, rendering static detection methods increasingly ineffective. Existing URL-based approaches suffer from limited adaptability to emerging phishing patterns, mislabeled training data, and insufficient validation protocols. This paper proposes a hybrid phishing URL detection system that integrates Fuzzy C-Means (FCM) clustering with XGBoost classification, enhanced by a novel Micro Adaptive Feature Extractor (MAFE). The system employs a multi-stage pipeline: feature engineering generating 36 statistical and interaction features, MAFE producing 15 adaptive features through class-aware dynamic weighting, micro-pattern detection, and entropy analysis, and FCM with K=2 clusters providing soft membership features to XGBoost. A two-pass confidence-based …

Ai-Enhanced Fluorescein Angiography Detection Of Diabetes-Induced Silent Retinal Capillary Dropout And Rna-Seq Identification Of Pre-Symptomatic Biomarkers, Yiyan Peng, Huishi Toh, Dennis Clegg, Peng Jiiang

Biological, Geological, and Environmental Faculty Publications

Objective: Retinal capillary dropout, characterized by acellular capillaries or "ghost vessels," is an early pathological sign of diabetic retinopathy (DR) that remains undetectable through standard clinical imaging techniques until visible morphological changes, such as microaneurysms or hemorrhages, occur. This study aims to develop a non-destructive artificial intelligence (AI)-based method using fluorescein angiography (FA) images to detect early-stage, silent retinal capillary dropout.

Methods: We utilized 94 FA images and corresponding destructive retinal capillary density measurements obtained through retinal trypsin digestion from 51 Nile rats. Early capillary dropout was defined as having an acellular capillary density of >= 18 counts per mm2. …

Maternal Microchimerism As A Mechanism Of Developmental Origins Of Health And Disease, Amy M. Boddy, Kristine J. Chua

Human Biology Open Access Pre-Prints

The in utero environment is now widely recognized as a critical determinant of health across the entire lifespan. The developmental origins of health and disease (DOHaD) framework has established that prenatal exposures, including maternal stress, infection, nutrition, and environmental toxins, can impact fetal development in profound ways associated with disease risk from infancy to old age. Yet a fundamental aspect of pregnancy, the bidirectional exchange of maternal and fetal cells, DNA, and other biological material, a phenomenon known as microchimerism, has received little attention in this context. Maternal cells and genomic material transfer to the developing fetus early in utero …

Continuous Process Intensification For Rare Earth Element Adsorption, Kyle Madill

Honors Theses

A continuous flow resonant vibratory adsorption swing reactor was designed to facilitate adsorption interactions between biochar and rare earth elements in a slurry or aqueous solution. A continuous mixing vessel can allow operators to run a large quantity of material through the RVM in an automatic manner that requires little supervision. This will save the operators time and allow them to focus on other research tasks. The reactor that was built was designed to bolt into Resodyn Acoustic Mixers’ Lab Resonance Acoustic Mixer-II (LabRAM-II). A design with two stacked stages within the LabRAM-II’s acoustic enclosure was settled on. These stages …

"Help Me Live It The Way You Do": Grounding Singaporean Responses To The Rorschach Situation, Casey Y. Lee

Electronic Theses and Dissertations

Contemporary research on the Rorschach and culture is striking for the latter’s disappearance as a variable of significance (Meyer et al., 2015; Meyer et al., 2007; Mihura et al., 2013; Viglione & Hilsenroth, 2001). This erasure is chronicled and reproduced in the narratives of universal objectivity, of extensive international meta-analyses, of replications, of standardized norms (Ritzler, 2004; Smith et al., 2018; Smith et al., 2020; Weiner, 2004). A different story emerges, however, when we ask, how has culture disappeared? The proposed study is a multimethod qualitative analysis of Singaporean responses to the Rorschach, aimed at generating sensitive yet critical discourses …

Parents’ Perceptions Of Aai’S Effect On Social Interaction & Communication For Individuals With Asd And/Or Adhd​, Alexis E. Morris, Zeida Gutierrez

Summer 2026 OTD Capstone Symposium

This research study will investigate the impact of animal-assisted interventions (AAI) on social interaction and communication skills of children or young adults formally diagnosed with autism spectrum disorder (ASD) and/or attention-deficit/hyperactivity disorder (ADHD) based on self or parent/caregiver report.

Children with ASD and ADHD experience deficits in communication and social participation that limit engagement in meaningful childhood occupations and peer relationships, highlighting the need for alternative, motivating intervention approaches. Animal-assisted interventions may provide a supportive and engaging environment that promotes emotional regulation, joint attention, and social reciprocity, and communication by enhancing participation in daily occupations.

The hypothesis for this study …

2026-08-07 Agenda Booklet, Morehead State University. Board Of Regents.

Morehead State Board of Regents Agenda Books and Meeting Minutes

Agenda booklet for the Board of Regents meeting of August 7, 2026, held in Prestonsburg, which includes the meeting minutes of the meeting held on June 12, 2026.