Digital Commons Network^™

Improving Early Detection Of Lung Cancer In Underserved Primary Care Settings, Trent Arden Goode, Ii

Walden Dissertations and Doctoral Studies

Lung cancer is the leading cause of cancer-related mortality in the United States, with underserved populations experiencing higher rates of late-stage diagnosis and preventable death. Despite established screening guidelines, adherence within primary care remains inconsistent, particularly in safety-net settings, reflecting a healthcare administration problem driven by organizational structures and care processes. The purpose of this integrative review was to identify administrative interventions that improve primary care provider adherence to lung cancer screening referral guidelines in safety-net healthcare settings. Guided by the Donabedian Quality Framework, a systematic integrative review was conducted to examine how healthcare structures and processes influence screening implementation. …

The Perception Of Fentanyl’S Harm, Rachel Antenucci

ETDs from 2020-2029

While drug overdose deaths have generally decreased in the past year, close to 60,000 overdoses involving opioids occurred in 2024. The opioid crisis has lasted over two decades and is now in the fourth wave. The fourth wave has been characterized by overdoses resulting from fentanyl adulteration in the drug supply and polysubstance overdoses involving fentanyl. The purpose of the current study is to compare the perceived harm of fentanyl to other drugs of abuse and identify differences in the perceived harm of fentanyl between groups of people who use substances. An online survey was conducted across 15 states in …

Nilotinib-Mediated Reprogramming Of Bone Marrow Macrophages Alters Hematopoietic Stem Cell Fate In Chronic Myeloid Leukemia, Tiffany Davia Ricketts

ETDs from 2020-2029

Tyrosine kinase inhibition (TKI) is highly effective and promotes favorable long-term outcomes for many patients with chronic myeloid leukemia (CML). However, many patients experience treatment resistance or recurrence after TKI cessation due to leukemic stem cell (LSC) persistence within the hematopoietic stem cell (HSC) niche. Within the niche, macrophages adopt different activation states to alter HSC function, however, CML disrupts niche signals to selectively support LSCs and macrophages may contribute to this process. We hypothesize that macrophages contribute to pro-inflammatory activation within the niche to promote LSC development and nilotinib will reprogram macrophages to selectively support non-leukemic stem cells. To …

Conserved Chromatin Programs Orchestrate Cardiac Cell States In Health And Disease And Drive Cardiomyocyte Proliferation After Injury, Xiaoxiao Geng

ETDs from 2020-2029

Chromatin structure is a central regulator of gene expression and cellular identity, yet the chromatin structural factors driving cardiac disease and regeneration remain incompletely defined. This dissertation investigates how modulation of chromatin architecture shapes pathological and regenerative cardiac phenotypes through integrated single-cell transcriptomic, epigenomic, and functional analyses. To determine whether chromatin structural regulators distinguish healthy from diseased cardiac states, we curated a comprehensive list of chromatin structural genes and applied it to single-nuclei RNA sequencing datasets from human hearts with and without dilated cardiomyopathy (DCM). Chromatin structural gene expression effectively stratified cardiomyocyte and fibroblast populations by disease status. Diseased cardiomyocytes …

Montana Kaimin, January 29, 2026, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Making Waves Podcast: Individual Science Communication With A Common Thread, C. Rose, H. Harrison, K. Coffie, E. Burke, A. Gielazyn, J. Kiplinger, L. Nofsinger, J. Cardin, E. Graves, S. Campbell, A. R. Arellano

Making Waves REU

• Give students tangible experience learning, working, and educating in the discipline of oceanographic research
• Provide an immersive ocean science experience for undergraduates
• Communicate research and findings to a general audience

Downregulation Of Slc40a1 Leads To Iron Accumulation In Fibrotic Lung Fibroblasts, Quanjin Dang, Chaoqun Huang, Yurong Liang, Akshaya Surendran, Dharanya Muthiah, Kishore Vaddadi, Sankha Hewawasam, Tingting W Mills, Lin Liu

Faculty, Staff and Student Publications

Iron is an essential nutrient for almost all organisms. However, excess iron generates reactive oxygen species and causes tissue injuries. Iron is implicated in idiopathic pulmonary fibrosis (IPF). In this study, we examined iron accumulation in fibrotic lung fibroblasts and the underlying mechanisms. We hypothesize that the downregulation of Solute Carrier Family 40 Member 1 (SLC40A1) results in iron accumulation in lung fibroblasts of IPF patients. Using a Prussian Blue iron staining, we found that iron accumulated in the fibrotic region of the lungs from IPF patients and bleomycin- and asbestos-induced lung fibrosis mice. Iron was partially co-localized with the …

The Origin Of Hepatocellular Carcinoma Depends On Metabolic Zonation, Jason Guo, Roger Liang, Andrew Chung, Zhijie Li, Boyuan Li, Eric Chen, Lin Li, Jingjing Wang, Meng-Hsiung Hsieh, Ivy Xiangyi Fang, Benjamin Kroger, Yunguan Wang, Min Zhu, Xiongzhao Ren, Greg Mannino, Yuemeng Jia, Yonglong Wei, Stephen Moore, Daniel J Siegwart, Stephen S Chung, Zixi Wang, Tripti Sharma, Suman Komjeti, Yi Han, Purva Gopal, Guanghua Xiao, Tao Wang, Hao Zhu

Faculty, Staff and Student Publications

The origin of cancer is poorly understood because premalignant cells are rarely followed in their native environments. Although the spatial compartmentalization of metabolic functions is critical for proper liver function, it is unknown whether cancers arise from some zones but not others and whether there are metabolic determinants of cancer risk. Zone-specific, mosaic introduction of Ctnnb1 (catenin beta 1) and Arid2 (AT-rich interaction domain 2) mutations, commonly co-mutated genes in hepatocellular carcinoma (HCC), in mouse models showed that position and metabolic context determine clone fates. Ctnnb1/Arid2-driven cancers were much more likely to arise in zone 3. The …

January 29, 2026, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Galway: Making A Capital Of Culture (Patrick Collins, Orpen Press, 2023), Connell Vaughan

Research Outputs: 2025-Present

Patrick Collins’ recent book details the development of the cultural industries and placemaking in the Galway region over the past century or so. Focusing on the “peripheral” position of the region, its long relationship to film making, and informed by Galway’s successful application for the European Capital of Culture in 2020, Collins argues for the unique nature of the region as a site of cultural production and consumption. While the book offers moments of insight, particularly in its discussion of ‘festivalisation’, it ultimately lacks the analytical depth and coherence needed to fully capture Galway’s complex cultural identity. No sustained critical …

The Risc-V Fpga (Rvfpga) Teaching Package, Daniel Chaver, Sarah Harris, Luis Pinuel, Olof Kindgren, Zubair Kakakhel, Chris Owen, Roy Kravitz, Jose I. Gomez-Perez, Fernando Castro, Katzalin Olcoz, Multiple Additional Authors

Electrical and Computer Engineering Faculty Publications and Presentations

RISC-V is a free and open-standard ISA based on RISC principles, allowing anyone to design, manufacture, and sell RISC-V chips and software. Its flexibility and growing ecosystem have made it popular in research, education, and industry, increasing the need for educational materials. This paper provides an in-depth description of the RVfpga course, which offers a solid introduction to computer architecture using the RISC-V instruction set and FPGA technology. It focuses on providing hands-on experience with real-world RISC-V cores, the VeeR EH1 and EL2 cores, developed by Western Digital and hosted by ChipsAlliance. The course targets students and educators in computing-related …

The Ai Doc: Or How I Became An Apocaloptimist, John C. Lyden

Journal of Religion & Film

This is a film review of The AI Doc: Or How I Became an Apocaloptimist (2026), directed by Daniel Roher and Charlie Tyrell.

Food Security, Industrialized Agriculture, And A Changing Global Climate: Perspectives On The United States And Cuba, Mary Jane Angelo

Florida Journal of International Law

This Article outlines the challenges of feeding a growing population in a time of climate change and in the shadow of the risks presented by industrialized agriculture. Part II presents an overview of current food insecurity and explores the likely exacerbation that will result from the impacts of climate change. Part III compares the evolution of agricultural systems in the United States and Cuba. This part also examines the environmental harms caused by industrialized agriculture in the United States and the limited protection offered by U.S. environmental law to protect against these harms. This part then turns to the evolution …

Agricultural Policy And Rural Development In Cuba, The Public Agriculture Section, Maritza De La Caridad Mc Cormack Bequer

Florida Journal of International Law

No abstract provided.

The Moravian Dead Houses Of Labrador, Canada, Dale Gilbert Jarvis

Communal Societies

No abstract provided.

Ephrata And Moravian Relations: The View From Ephrata, Jeffrey Bach

Communal Societies

No abstract provided.

Not A Lifestyle, Charles E. Moore

Communal Societies

No abstract provided.

Stories And Storytelling In Intentional Community, Nell Cook

Communal Societies

No abstract provided.

“The Male Work Ethic Was Busted”: Black Bear Ranch, 1968-1974, Tim Hodgdon

Communal Societies

No abstract provided.

Harmony Hills: A Twentieth Century Mormon Cooperative, Jessie L. Embry, Janiece Johnson

Communal Societies

No abstract provided.

A General Typology Of Communalism, Robert Bates Graber, C. Raymond Barrow

Communal Societies

No abstract provided.

Ha-Chan, Shake Your Booty!, John C. Lyden

Journal of Religion & Film

This is a film review of Ha-Chan, Shake Your Booty! (2026), directed by Josef Kubota Wladyka.

Review Of A Priceless View: My Spiritual Homecoming, Giles Wayland-Smith

Communal Societies

No abstract provided.

Timon Communities In The Netherlands, Martine Vonk

Communal Societies

No abstract provided.

Vitruvius To Vinyl: Paradise Lost: A Field Report From The Cul-De-Sacs Of Despair, Annette Lucia Giesecke

Communal Societies

No abstract provided.

Dating And Educational Behaviors Of Hutterian Youth, Suzanne R. Smith, Bron B. Ingoldsby

Communal Societies

No abstract provided.

Basic Sense: The More Philosophy Of Victor Baranco And The Institute Of Human Abilities, Laurie Rivlin Heller

Communal Societies

No abstract provided.

Resisting Commodification (With Friends!): Facebook And The Spectacle Of Capitalism, Wilton S. Wright

Fast Capitalism

No abstract provided.

Digital Media And The Convergence Of Geographic Cultures, Marcus Schulzke

Fast Capitalism

No abstract provided.

The Imperial Eye, Mark P. Worrell, Daniel Krier

Fast Capitalism

No abstract provided.