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The Effects Of Endocrine Disruptors On The Female Reproductive System, Riza Gökhan Baykal, Reyhan Ersoy

Turkish Journal of Medical Sciences

Endocrine-disrupting chemicals (EDCs) are a diverse, comprehensive group of mostly synthetic chemicals that disrupt many physiological functions in humans and animals. EDCs are particularly disruptive to the female reproductive system. Reproductive function in women is a dynamic process regulated by the hypothalamic–pituitary–ovarian axis. EDCs show their effects on the reproductive system through estrogenic, antiestrogenic, androgenic, and antiandrogenic effects or by directly affecting gonadotropin-releasing hormone secretion. Disruption in the menstrual cycle, decrease in fertility, infertility, increased risk of miscarriage, polycystic ovary syndrome, endometriosis, early or delayed puberty, and hormone-sensitive cancers can be listed as the main negative effects of endocrine disruptors …

Effects Of Endocrine Disruptors On Thyroid Hormone Synthesis And Function And Consequences Of Fetal Exposure, Esra Eraslan Aydemi̇r, Mustafa Şahi̇n

Turkish Journal of Medical Sciences

Fetal development relies on intricate maternal-fetal-placental interactions, with thyroid hormones playing a critical role in growth and neurogenesis. Exposure to endocrine-disrupting chemicals (EDCs) during pregnancy has emerged as a significant risk factor for thyroid dysfunction and its associated developmental and cognitive disorders. EDCs, including bisphenol A (BPA), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), perfluorinated compounds (PFAS), pesticides, and heavy metals, disrupt thyroid hormone synthesis, secretion, and metabolism. Mechanisms include binding to thyroid hormone receptors, impairing the hypothalamic-pituitary-thyroid axis, and altering thyroid peroxidase activity. BPA exposure, for instance, reduces free and total T4 levels and interferes with deiodinase activity. Similarly, …

Her2-Low And Her2-Ultralow Metastatic Breast Cancer And Trastuzumab Deruxtecan: Common Clinical Questions And Answers, Nusayba A Bagegni, Karthik V Giridhar, Daphne Stewart

2020-Current year OA Pubs

Approximately 80% of invasive breast cancers are classified as human epidermal growth factor receptor 2 (HER2)-negative; however, many of these tumors have detectable levels of HER2 surface expression. Trastuzumab deruxtecan (T-DXd) is a HER2-directed antibody-drug conjugate with a membrane-permeable payload that is cytotoxic to both HER2-expressing tumor cells and neighboring cells via the bystander antitumor effect. T-DXd has shown significant antitumor activity in clinical trials for patients with HER2-positive (immunohistochemistry [IHC] 3+ or IHC 2+/in situ hybridization [ISH]+) breast cancer. In addition, the results of the DESTINY-Breast04 trial demonstrated the clinical benefit of T-DXd in patients with HER2-low (IHC 1+ …

2025-12-17 Course Proposal / Course Suspension / Deletion Forms, Morehead State University. Faculty Senate., University Graduate Committee.

Faculty Senate Records

Course proposal, suspension, and deletion forms approved on December 17, 2025 by the University Graduate Committee.

2025-12-17 University Graduate Committee Meeting Minutes, Morehead State University. Faculty Senate., University Graduate Committee.

Faculty Senate Records

Meeting minutes from the University Graduate Committee from December 17, 2025.

Development Of A Multispectral Collagen Detection Dermatology Device For Delineation Of Non-Melanoma Skin Cancers, Anmol Jarang

McKelvey School of Engineering Graduate Student Theses & Dissertations

To diagnose and manage skin disease, clinicians primarily use visual inspection aided with dermatoscopes, which are cross-polarized magnifiers. In recent years, digital cross polarized multispectral imaging systems have been developed to quantitatively assess skin disease. For example, systems like the one developed by Yaroslavsky et al., which utilize red and blue filters, can non-invasively assess the collagen network in the dermis(Yaroslavsky et al., 2003). Visualization of collagen network disruption can make it easier to visualize the boundaries of skin cancers like keratinocyte carcinoma, and therefore easier to excise completely. Current systems use external bandpass filters in front of cameras to …

Fpga-Accelerated Computational Photon Counting, Chibueze Onyeador

McKelvey School of Engineering Graduate Student Theses & Dissertations

Fluorescence Lifetime Imaging Microscopy (FLIM) is a powerful tool for biomedical re- search. It leverages fluorescence of biological samples to visualize and characterize biological dynamics and molecular interactions. FLIM utilizes fluorescence lifetime, the average time a molecule stays in its excited state after absorbing a photon, to investigate the dynamics of biological samples.

Ultra-fast and precise (ps-ns) timing fluorescence acquisition techniques suffer from different trade-offs. Some methods suffer from high dead times, decreased accuracy in fluorescence lifetime calculations, and high data volumes and transfers. Finding a new method that can provide the best performance while experiencing low dead times, adequate …

Enhancing Aerosol Scattering Measurements: Performance Evaluation And Quality Assurance Of Airphoton Integrating Nephelometers In The Surface Particulate Matter Network, Kamlendra Singh Pathak

McKelvey School of Engineering Graduate Student Theses & Dissertations

Integrating nephelometers are key instruments for quantifying aerosol light scattering, a fundamental parameter governing the direct radiative effect of aerosols on climate and visibility, and for interpreting satellite observations of aerosol optical depth. The AirPhoton integrating nephelometer quantifies aerosol light scattering by measuring total scattering from the sample air and subtracting a clean-air reference that represents Rayleigh scattering, instrument wall scattering, and detector background noise. Measurement accuracy depends on rigorous calibration and regular performance evaluation to account for instrumental drift and environmental influences. This study presents a field performance evaluation of the AirPhoton integrating nephelometer within the global Surface Particulate …

Assessing Smooth Muscle Cell Death In Elastase-Treated Mouse Aortas, Bebel B. Trani

Mechanical Engineering and Materials Science Independent Study

No abstract provided.

Managing For Global Sustainability, Maria Assunta C. Cuyegkeng

Journal of Management for Global Sustainability

No abstract provided.

University Living Labs For Sustainability: Governance, Pedagogy, And Global North-South Patterns, Skilty C. Labastilla

Journal of Management for Global Sustainability

This scoping review examines how 72 higher education institutions (HEIs) operationalize sustainability through living labs (LLs), synthesizing evidence from 89 studies published between 2010 and 2025. Using Arksey and O’Malley’s (2005) framework, the review maps how LLs coordinate governance, pedagogy, operational experimentation, and stakeholder engagement, comparing 63 Global North (GN) and 26 Global South (GS) cases. GN LLs feature formalized governance and resource-intensive infrastructures linking curriculum, operations, and data-driven experimentation. GS LLs operate under resource constraints but exhibit strong community embedding, participatory co-production, and socio-ecological responsiveness. Institutionalization depends on hybrid configurations where bottom-up experimentation aligns with top-down authority. Observed governance, …

Short-Term Tillage Effects On Greenhouse Gas Emissions And Global Warming Potential From Soybean In Southeast Arkansas, Lauren Gwaltney, Kristofor R. Brye, Della Lunga Diego, Jonathan B. Brye, Trenton Roberts, Samuel B. Fernandes, Michael B. Daniels

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Reduced tillage (RT) is a common conservation agriculture practice, generally regarded to be a valuable greenhouse gas (GHG) mitigation approach through increasing soil carbon (C) stocks. However, direct GHG measurements from RT compared to conventional tillage (CT) treatments can vary greatly depending on site-specific soil properties and management practices. The objective of this study was to evaluate the short-term effects of RT on soil-to-atmosphere carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) fluxes and emissions, global warming potential (GWP), yield, and emissions intensity (EI) throughout the 2024 soybean (Glycine max) growing season in a southeast Arkansas production field. Bulk …

Towards Science-Based Quantitative Conservation Management Plan Add-Ons For All Alaskan Squirrel Species: Current And Future Distributions, Conservation Management, Contaminant Exposure, And Their Role In Alaska Native Communities, Moriz Steiner

Biological Sciences

Squirrels are widespread in Alaska, yet a science-based conservation management plan (CMP) is absent at the state level. Squirrels are killed year-round with no bag limits, while population metrics remain unknown and conservation statuses disputed. This thesis proposes modern tools and approaches as addons for long-term, sustainable, holistic CMPs for all Alaskan squirrel species in a changing climate. Chapter 1 provides an overview of squirrels' current roles and uses in Alaska alongside existing management practices and regulations. Chapters 2 and 3 conduct thorough conservation assessments by analyzing and predicting current and future distributions of squirrel species across Alaska and a …

Osteoprogenitor Cells From Non-Regenerative Bone Show Greater Resistance To Cellular Stress Than Those From Regenerative Bone, Joshua Broussard, Sylvia Culpepper, Tyrel Long, Alexander J. Trostle, Robert J. Tower, Mimi C. Sammarco, Jennifer Simkin

School of Medicine Faculty Publications

INTRODUCTION: Bone regeneration following injury depends on osteoprogenitor cells derived predominantly from the periosteum. Incomplete regeneration has been attributed to both cell-extrinsic factors (e.g., environment, inflammation, mechanical instability) and cell-intrinsic factors (e.g., impaired proliferation or differentiation of stem cells). In the digit amputation mouse model, amputation through the third phalanx (P3) supports complete regeneration, while amputation through the second phalanx (P2) results in callus formation and scarring. Periosteal cells are known to be the major contributing cell source for repair and regeneration. Yet the healing outcomes of P2 and P3 amputations are significantly different. This study tests whether P2 and …

Lindenwood Digest, December 17, 2025, Lindenwood University

Lindenwood Digest

The December 17, 2025, edition of the Lindenwood University Employee Digest provides essential year-end updates and preparation instructions for the upcoming winter break. Key highlights include:

• Campus Operations: Instructions for winterizing workspaces include setting thermostats to 67 degrees and ensuring all electronics are powered down. Updated winter break hours are provided for campus facilities such as the Evans Rec Center and Library Services.

• Upcoming Programs: The Lindenwood Learning Academy has opened registration for Spring 2026 Teaching Squares and Professional Learning Communities, with a sign-up deadline of January 14, 2026.

• Community News: The Communications team announced a new monthly newsletter for …

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40 Priority Questions To Advance Understanding Of The Risks And Opportunities Of Uk Marine Heatwaves, Zoe Jacobs, Kathryn E. Smith, Jules B. Kajtar, Dan A. Smale, Pippa J. Moore, Fabrice Stephenson, Michael T. Burrows, Caroline Rowland, Richard Renshaw, Sophy Oliver, Martyn Jakins-Pollard, Freya Ivy Palmer, Alice Kloker, Craig Baker-Austin, Bryony Townhill, Sian Rees, Sarah Coulthard, Ekaterina Popova

School of Biological and Marine Sciences

Marine heatwaves (MHWs) are periods of anomalously warm sea temperatures that are becoming increasingly recognised as ocean stressors. Globally, MHWs have impacted marine ecosystems, with significant socioeconomic implications for coastal communities and industries. The unprecedented MHW that occurred in the waters surrounding the UK and Ireland in summer 2023 highlighted a crucial gap in our understanding of the region-specific characteristics of MHWs and their impacts on marine ecosystems, the services they underpin, the blue economy and society. Using diverse expert opinion, we propose 40 priority questions for interdisciplinary research in the UK that must urgently be addressed to prepare for …

Co-Production Of A Mobile Application For Parents Of Acutely Ill Children Under Five: ‘Ipoorly Child Symptom Checker, Sarah Neill, Amy Rathbone, John Downey, Monica Lakhanpaul, Matt Carey

School of Nursing and Midwifery

Acutely ill children under five years of age are frequent and increasing users of urgent and emergency care services despite there being no increase in acuity of presenting illnesses. This raises concerns about parents’ level of knowledge and confidence in assessing the severity of symptoms of acute illness, despite the abundance of digital information available. MethodBuilding on prior work to co-develop the content for a mobile app for parents of acutely ill children, we co-designed the iPoorly child symptom checker app using an experience based co-design methodology with seven parent and seven health professional patient and public involvement representatives. The …

Unmasking Oral Health Stigma: A Qualitative Scoping Review, J Doughty, J Booth, M Smith, K Saini, M Paisi, A Rodriguez, A Levine, C Bedos, V Muirhead, C Martins De Barros, C Freeborn

Peninsula Dental School

INTRODUCTION: Health-related stigma can limit access to care, impair adherence to treatment, and negatively impact mental health and quality-of-life. Oral health stigma, defined as stigma arising from oral conditions that diverge from sociocultural norms, operates through labelling, stereotyping, othering, and exclusion. Oral health stigma can lead to shame, diminished self-confidence, and avoidance of dental care, creating a self-perpetuating cycle of poor oral health and reinforcing internalised and anticipated stigma. While previous research has explored the social implications of oral appearance, little is known about the broader concept of oral health stigma or strategies to mitigate it.

METHODS: This scoping review …

Incidence Of Bacterial Chondronecrosis With Osteomyelitis Lameness In Commercial Duck Flocks In Mojokerto, Indonesia, Andi Asnayanti, Siti Azizah, Anif Mukaromah Wati, Ahmad Ridwan, Ahmad Arman Dahlan, Dinda Rosalita, Anh Dang Trieu Do, Adnan Alrubaye

Poultry Science Faculty Publications and Presentations

Bacterial Chondronecrosis with Osteomyelitis (BCO) lameness is an infection of opportunistic bacteria in the structural skeletal bones impacting multiple animal species, particularly poultry species. BCO lameness results in significant financial losses to industrial poultry production and increases the risk of foodborne illnesses, posing a major threat to consumers' food safety. As BCO lameness is an inherent risk of fast body weight gain in poultry species, especially broiler chickens, abundant studies have been conducted in broilers and turkeys. Nevertheless, BCO lameness incidence in ducks remains elusive. Thus, this is the first survey investigating the prevalence of BCO lameness cases in ducks. …

Programmable Acoustofluidic Engineering For Creating Gradient Biomaterials, Jujing Lu, Ye He, Jianping Xia, Mingyuan Liu, Joseph Rich, Ke Jin, Ruoyu Zhong, Kaichun Yang, Jiao Qian, Ying Chen, Ke Li, Zhiteng Ma, Tony Jun Huang

Faculty Publications

Gradient biomaterials that exhibit spatially varying physical, chemical, or biological properties can be used in various applications such as tissue engineering, organoid development, mechanobiology, and spatially controlled drug delivery. However, current fabrication methods often suffer from limited gradient precision, restricted material compatibility, and poor reproducibility. Here, we introduced gradient regulation via acoustofluidic dynamic engineering (GRADE), a programmable system to generate high-fidelity gradient biomaterials across different material systems. By incorporating focused interdigital transducers with the pulsed surface acoustic wave actuation, GRADE can achieve tunable and directional acoustic streaming (0 to 22 millimeters per second), which allows accurate regulation of the gradient …

Investigating The Polygenic Relationship Between Heavy Cannabis Use And Schizophrenia In The All Of Us Research Program, Isabelle Austin-Zimmerman, Hayley H A Thorpe, John J Meredith, Jibran Y Khokhar, Tian Ge, Marta Di Forti, Arpana Agrawal, Emma C Johnson, Sandra Sanchez-Roige

2020-Current year OA Pubs

BACKGROUND: Decades of research have identified a strong association between heavy cannabis use and schizophrenia (SCZ), with evidence of correlated genetic factors. However, many studies on the genetic relationship between cannabis use and psychosis have lacked data on both phenotypes within the same individuals, creating challenges due to unmeasured confounding. We aimed to address this by using multimodal data from the All of Us Research Program, which contains genetic data as well as information on SCZ diagnosis and cannabis use.

METHODS: We tested the association between cannabis use disorder (CUD) and SCZ polygenic scores (PGSs) with SCZ and heavy cannabis …

National Football League (Nfl) "Dynamic Kickoff" Rule Change: A Comparative Analysis Of Concussion And Musculoskeletal Injury Incidence, Troy Puga, Tanner Haechten, Coleman Cush, Mckenna Box, Hans Drawbert, John Riehl

Student Publications

Background: Kickoffs in the National Football League (NFL) are historically one of the most dangerous plays during an NFL game, with high levels of injuries. In 2024, the NFL introduced new rules aimed at reducing injuries during kickoffs, enhancing player safety, and increasing the frequency of kick returns.

Purpose: To evaluate whether the NFL kickoff rule changes in 2024 had any effect on the incidence of injuries, particularly with a focus on concussions.

Study design: Descriptive epidemiology study.

Methods: Injuries on kickoffs were identified for the 2022, 2023, and 2024 NFL seasons using the transcribed game book for each game …

Invisible No More: National Solutions For Protecting Unaccompanied And Separated Migrant Children In Egypt, Enas Abdel Azim, Noran Khorsheed, Raghda Bahy Elessawy, Tharwat Abaza

Papers, Posters, and Presentations

Egypt has a strategic geographical position as a significant destination and transit country for unaccompanied and separated migrant children (UASC). With a substantial and rapidly increasing migrant population, exacerbated by recent regional influxes, the country’s public infrastructure and resources are experiencing considerable strain. While Egypt has demonstrated its commitment to child rights through the ratification of key international instruments like the Convention on the Rights of the Child (CRC) and the African Charter on the Rights and Welfare of the Child (ACRWC), UASC in the country nonetheless face complex protection challenges, including legal visibility concerns, risk for exploitation, and barriers …

Plan Your Way To Tenure And/Or Promotion, Wendy Doucette, Jill Cirasella

Journal of Graduate Librarianship

In this editorial, we share our best advice for preparing the dossier necessary for professional advancement. While our advice is unavoidably shaped by the specifics of our experiences and universities, we believe most of it is broadly applicable to academic librarians in general. We cluster our advice into three categories: framework and planning, building your portfolio, and ongoing recordkeeping. We hope this “from the ground up” presentation will help those new to academic librarianship, though it’s never too late for more experienced librarians to (re)consider their own approaches.

Mine Pit Song, 1998, Bill Gessner, Carolyn King

Bill Gessner Song Lyrics and Poems

"Song lyrics for "Mine Pit Song, 1998" by Bill Gessner and Carolyn King. 5 sheets of paper including handwritten lyrics, typed out lyrics and guitar chords. The typed up documents show revisions made. The documents indicate this song was created on August 9th and 10th of 1998. The song references the Iron Range in northern Minnesota.

"Soft Spot," Song Lyrics, Undated, Bill Gessner

Bill Gessner Song Lyrics and Poems

Song lyrics for "Soft Spot" by Bill Gessner. One page total of lyrics. This song talks about love and a soft spot in his heart.

"Swimming Lessons," Song Lyrics, 2002, Bill Gessner

Bill Gessner Song Lyrics and Poems

Song lyrics for "Swimming Lessons" by Bill Gessner. Two sheets of paper with typed lyrics. The song "Swimming Lessons" was written in honor of the late John Quaday, and was inspired by Carolyn King. The song is about John's life and a young girl's memories of him giving her swimming lessons.

"Minneapolis Sound," Song Lyrics, Undated, Bill Gessner

Bill Gessner Song Lyrics and Poems

Song lyrics for "Minneapolis Sound” by Bill Gessner. A photocopy of a handwritten notebook page. Talks about Minneapolis as a place and the time he spent there. This song doesn't have a chorus.

A Temple For The Creator To Abide: The Soul Sanctuary In Ellen G. White’S Writings, Abner F. Hernández

Ellen White Issues Symposium

No abstract provided.

Heavenly Or Soul Sanctuary? Some Holistic Theological And Ethical Implications, Davide Sciarabba

Ellen White Issues Symposium

No abstract provided.