Digital Commons Network^™

Zika Virus Encephalitis Causes Transient Reduction Of Functional Cortical Connectivity, Shannon C Agner, Lindsey M Brier, Jeremy D Hill, Ethan Y Liu, Annie Bice, Rachel M Rahn, Shengxuan Chen, Joseph P Culver, Robyn S Klein

2020-Current year OA Pubs

SIGNIFICANCE: Determining the long-term cognitive impact of infections is clinically challenging. Using functional cortical connectivity, we demonstrate that interhemispheric cortical connectivity is decreased in individuals with acute Zika virus (ZIKV) encephalitis. This correlates with decreased presynaptic terminals in the somatosensory cortex. During recovery from ZIKV infection, presynaptic terminals recover, which is associated with recovered interhemispheric connectivity. This supports the contribution of synapses in the cortex to functional networks in the brain, which can be detected by widefield optical imaging. Although myeloid cell and astrocyte numbers are still increased during recovery, RNA transcription of multiple proinflammatory cytokines that increase during acute …

Clinical Trials For Wolfram Syndrome Neurodegeneration: Novel Design, Endpoints, And Analysis Models, Guoqiao Wang, Zhaolong Adrian Li, Ling Chen, Heather Lugar, Tamara Hershey

2020-Current year OA Pubs

OBJECTIVE: Wolfram syndrome, an ultra-rare condition, currently lacks effective treatment options. The rarity of this disease presents significant challenges in conducting clinical trials, particularly in achieving sufficient statistical power (e.g., 80%). The objective of this study is to propose a novel clinical trial design based on real-world data to reduce the sample size required for conducting clinical trials for Wolfram syndrome.

METHODS: We propose a novel clinical trial design with three key features aimed at reducing sample size and improve efficiency: (i) Pooling historical/external controls from a longitudinal observational study conducted by the Washington University Wolfram Research Clinic. (ii) Utilizing …

Examining And Classifying Reasons For Missing Viral Loads Among Adults Living With Hiv: An Extended Outcome Investigation And Ascertainment Approach In Western Kenya, Harriet Fridah Adhiambo, Jayne Lewis-Kulzer, Edwin Nyagesoa, Sarah Gimbel, Eliud Akama, Dorothy Mangale, Lina Montonya, Ingrid Eshun-Wilson, Sarah Iguna, Everlyne Nyandieka, Elizabeth Bukusi, Lisa Abuogi, Thomas Odeny, Maya L. Petersen, Elvin H. Geng

2020-Current year OA Pubs

Gaps in HIV RNA monitoring persist globally impeding the ability to determine clinical progress and outcomes. This study systematically evaluated provider (e.g., guideline non-adherence), system (e.g., laboratory error) and participant-level (e.g., refusal) drivers of missed viral load (VL) monitoring measurements among people with HIV in Kenya. Adults aged 18-65 years were followed across five health facilities in Kenya as part of a clinical trial (NCT#02338739) where HIV RNA monitoring was done routinely. Instances of missed VL despite being indicated per Kenyan guidelines were identified. An algorithm for assessing root causes of missing HIV RNA was developed and generalized linear models …

Poor Sleep Is Common In Treatment-Resistant Late-Life Depression And Associated With Poorer Antidepressant Response: Findings From The Optimum Clinical Trial, Michael S B Mak, Marie Anne Gebara, Eric J Lenze, Daniel M Blumberger, Patrick J Brown, Pilar Cristancho, Alastair J Flint, Jordan F Karp, Helen Lavretsky, J Philip Miller, Charles F Reynolds 3rd, Steven P Roose, Benoit H Mulsant, Sarah T Stahl

2020-Current year OA Pubs

BACKGROUND: Adults with treatment-resistant late-life depression (TRLLD) have high rates of sleep problems; however, little is known about the occurrence and change in sleep during pharmacotherapy of TRLLD. This analysis examined: (1) the occurrence of insufficient sleep among adults with TRLLD; (2) how sleep changed during pharmacotherapy; and (3) whether treatment outcomes differed among participants with persistent insufficient sleep, worsened sleep, improved sleep, or persistent sufficient sleep.

METHODS: Secondary analysis of data from 634 participants age 60+ years in the OPTIMUM clinical trial for TRLLD. Sleep was assessed using the sleep item from the Montgomery-Asberg Depression Rating Scale at the …

Molecular Regulation And Therapeutic Targeting Of Vldl Production In Cardiometabolic Disease, Kendall H Burks, Nathan O Stitziel, Nicholas O Davidson

2020-Current year OA Pubs

There exists a complex relationship between steatotic liver disease (SLD) and atherosclerotic cardiovascular disease (CVD). CVD is a leading cause of morbidity and mortality among individuals with SLD, particularly those with metabolic dysfunction-associated SLD (MASLD), a significant proportion of whom also exhibit features of insulin resistance. Recent evidence supports an expanded role of very low-density lipoprotein (VLDL) in the pathogenesis of CVD in patients, both with and without associated metabolic dysfunction. VLDL represents the major vehicle for exporting neutral lipid from hepatocytes, with each particle containing one molecule of apolipoproteinB100 (APOB100). VLDL production becomes dysregulated under conditions characteristic of MASLD …

Reliability Of Wrist Arthroscopy In The Diagnosis And Treatment Of Triangular Fibrocartilage Complex Tears, Elizabeth A Graesser, Lindley B Wall, Sanjeev Kakar, Jeffrey Yao, Marc J Richard, R Glenn Gaston, Charles A Goldfarb

2020-Current year OA Pubs

PURPOSE: Wrist arthroscopy is considered the gold standard for diagnosis of intra-articular wrist conditions including triangular fibrocartilage complex (TFCC) tears; however, the ability to reliably diagnose TFCC pathology during wrist arthroscopy is unclear. The purpose of this study was to assess the reliability of the diagnosis of TFCC tears on wrist arthroscopy videos.

METHODS: Five hand surgeons reviewed 43 cases on a secure web-based platform at two time points separated by 4-6 weeks. Each case included a deidentified clinical vignette and wrist radiographs with ulnar variance measurements and an arthroscopy video of ulnar wrist pathology, averaging 42 seconds. Surgeons were …

Medical Impact Of The College World Series On The Omaha Community, Benjamin Stevens, Jd Gregerson, Roarick Schollmeyer, Katie Weaver, Joseph Lippert

EMET Projects

No abstract provided.

Bad News, Rachel Sisley

EMET Projects

This is a representation of a patient sitting on the edge of his hospital bed. It is based on a memory I have from a clinical rotation, in which someone was diagnosed with cancer with a very poor prognosis. The dark green coating the room and his body represents the overwhelming fear he possibly feels. The blue represents sadness, while the red represents anger.

The Carceral State(S), Esther K. Hong

Michigan Journal of Race and Law

The carceral state is everywhere. Legal and social science scholars are increasingly using the carceral state concept to criticize various aspects, or even the entirety, of the United States. But despite how popular and common this term has become in writings about mass incarceration, criminal processes and punishments, and other forms of social control, the definition, conceptualization, and theorization of the carceral state are far from settled. This Article analyzes and contributes to this discussion by highlighting the diversity and fluidity of ideas surrounding the carceral state.

Although the term often appears without an express definition, the limited ones that …

Front Matter, University Of Michigan Law School

Michigan Journal of Race and Law

Front Matter for Volume 30, Issue 1 of Michigan Journal of Race & Law

Reformed But Not Repaired, Nia Johnson

Michigan Journal of Race and Law

Traditionally, scholars and policymakers concerned with making improvements to health care systems and structures have focused on insurance reform. The ACA— the United States’ most recent and substantial healthcare reform—was hoped to be an intervention that would help provide equity to all Americans. Indeed, scholars and policymakers viewed increasing access to health care through insurance coverage as a victory. And yet, despite these interventions, the COVID-19 pandemic revealed a number of policy gaps that disproportionately impacted racial minorities. Specifically, racially marginalized Americans still experienced the starkest disparities in COVID-19 complications and mortality. This has left scholars and policymakers to answer …

Actuator Disk Model For Aeropropulsive Coupling Effects In Vortex Particle Method, Eduardo Alvarez, Vineet Ahuja, Vinod Lakshminarayan, Aaron Perry, Ryan Anderson, Andrew Ning

Faculty Publications

Blown lift and distributed electric propulsion aircraft pose strong aeropropulsive coupling effects that cannot be ignored during the early stages of design. In this study, we develop an advanced actuator disk model (ADM) for aeropropulsive coupling effects of ducted fans with the vortex particle method (VPM). The advanced ADM consists of (1) an actuator disk at the rotor plane, (2) a surface vortex sheet modeling the mixing and convection of blade tip vorticity along walls, and (3) a powered wake at the exhaust. With these three components, a propulsion jet with an arbitrary velocity profile is formed and interactions with …

Instructional Designer Perspectives On The Pursuit Of Quality In Online Course Design, Jason K. Mcdonald, Stephen C. Yanchar

Faculty Publications

In this qualitative study we investigated the experiences of instructional designers as they sought to build quality into online courses. Through semi-structured interviews, we explored what enabled and hindered their pursuit of quality, how they experienced their efforts in this regard, what mattered to them, and complexities that accompanied this pursuit. Our analysis of participant experiences suggested four themes: (1) connections between quality and designers’ ability to act autonomously; (2) connections between quality and collaborative, team-based relationships; (3) ambivalence due to tensions between autonomy and collaboration; and (4) ways of coping with limits on autonomy and collaboration. We conclude our …

Comparing The Sensitivity And Specificity Of Novel Motor Assessments For Traumatic Brain Injury, Paula K. Johnson, Ariana M. Hedges-Muncy, Erin D. Bigler, Lorie Richards, Steven Knight Charles

Faculty Publications

Background: Portable technology that records movements with high accuracy provides potential for sensitive clinical movement tests for individuals who experienced a traumatic brain injury (TBI). Objective: (1)To present impairments assessed using markerless motion capture (MMC) and (2) to compare the sensitivity and specificity of the MMCmediated tests to each other and to common clinical tests. Design: Screening study, using as criterion standard the ability to classify participant with TBI versus control participant. Setting: Research laboratory. Participants: The study included 30 individuals with TBI and 101 control participants. Entry criteria included most recent head injury < 5 years old, no history of movement issues prior to injury, no movement-affecting medications, and sufficient cognitive ability to follow instructions. Interventions: Not applicable. Main Outcome Measures: Performance on MMC-mediated tests and existing clinical analogs. MMC-mediated tests included finger oscillation, simple reaction time, and visually guided movement tasks. For comparison, participants also completed the following clinical tests: Halstead–Reitan finger tapping, simple reaction time test, and Beery Visuomotor Integration test. Impairments were identified as test scores of participants with TBI that fell outside of the 95% interval of control participants’ test scores. Random forest analysis was used to calculate the sensitivity and specificity of MMC and clinical tests according to their ability to correctly classify participants with TBI and control participants. Results: MMC-mediated tests revealed impairments in more participants with TBI than clinical tests in all three TBI groups (mild, repeated, and moderate to severe). Similarly, MMC-mediated tests revealed a higher percentage of scores as impairments than clinical tests in all three groups with TBI. Furthermore, MMC-mediated tests proved more sensitive and more specific than clinical tests (70% versus 50% and 98% versus 93%, respectively). Conclusion: MMC-mediated tests are sensitive and specific (compared to traditional clinical tests) and have potential to fill a gap in clinical care of TBI.

How Overcoming Linguistic Discrimination Benefits The World, Joseph A. Stanley, Lisa Morgan Johnson, Eve Okura Koller, Vashti Wai Yu Lee, Hallie Davidson, Valeria Prieto Hurtado, Sam Keddington, Hazel Mattson, Abigail Mueller, Sydney Jo Pederson, Maryn Perschon, Reese Rugg, Eliza Whiting

Faculty Publications

What is linguistic discrimination?

• Restricting access or opportunities based on speech (e.g., accent, pronunciation, grammatical system, tone or pitch)
• One of the last socially acceptable discriminatory practices in the international community
• A source of injustice that impacts many of God’s children every day

Linguistic discrimination is real! Here’s what it looks like…

In Healthcare:

• More questions about insurance coverage; later appointments (Wisniewski and Walker 2020)
• Lower access to mental health services (Kugelmass 2016)
• More referrals for speech therapy (Charity Hudley et. al. 2018)

In Education:

• Students receiving negative judgments from teachers (Bowie & Bond 1994; Cecil 1988; Wheeler 2019)
• Teachers …

The Development Of A Rag-Based Artificial Intelligence Research Assistant (Aira), Hamid Vakilzadeh, David A. Wood

Faculty Publications

No abstract provided.

The Information Content Of Private Information Acquisition: Evidence From Foia Requests To The Sec, Dichu Bao, Janja Brendel, Michael S. Drake, Lixin (Nancy) Su

Faculty Publications

We analyze Freedom of Information Act (FOIA) requests submitted to the Securities and Exchange Commission (SEC), focusing on the value-relevance hypothesis and the directtrading hypothesis. Our empirical analysis reveals nuanced value relevance associated with different types of requests: Requests related to ongoing investigations and submitted by anonymous requesters are negatively correlated with future returns, while requests from investment firms and intellectual property firms predict positive future returns. Our findings also provide some support to the direct-trading hypothesis, showing that investment firms increase holdings of stocks for which they have filed FOIA requests, and short sellers exhibit heightened activity following requests …

Signaling Innovation: The Nontax Benefits Of Claiming R&D Tax Credits, Bradford F. Hepfer, Hannah W. Judd, Sarah C. Rice

Faculty Publications

Using the IPO setting, we test whether firms signal the quality of their investments in innovation activities by claiming R&D tax credits. We find the presence and amount of the R&D credit are each associated with lower information asymmetry and with higher investor demand at IPO. Conservatively, we estimate that sample firms realize additional IPO proceeds of 32–45 percent of their creditable R&D expenditures, indicating economically significant non-tax benefits associated with the R&D credit. We verify the R&D credit signal by showing its positive association with firms’ future patenting activity, patent citations, and post-IPO stock returns. Results from these tests …

Psychological Reactance Theory And Tax Evasion Intentions, Diana Falsetta, Brian C. Spilker

Faculty Publications

This study experimentally examines how tax administration service inefficiencies in the form of tax return processing delays from paper-filed tax returns indirectly affect taxpayer tax evasion intentions through taxpayers’ psychological reactance to the delay. We further consider whether this indirect effect is different when the taxpayer willingly chooses to paper file their tax return versus when the taxpayer is forced to do so. Consistent with Psychological Reactance Theory (PRT), we find that when taxpayers receive delayed refunds, they experience psychological reactance (e.g., anger and frustration with the tax administration) that increases their tax evasion intentions. Further, we find that the …

Price Transparency And Patient Engagement: Social Messaging Matters, Jace B. Garrett, Keaton C. Helquist, Steven D. Smith, William B. Tayler

Faculty Publications

OBJECTIVES: To examine the effects of price transparency and prosocial messaging on price-protected consumers’ health care choices as a potential cost-saving strategy to manage rising US health care expenditures.

STUDY DESIGN: Cross-sectional study. Participants were recruited to complete a basic questionnaire via Amazon’s Mechanical Turk program. Participants’ selections were subsequently collected and analyzed.

METHODS: Participants (N = 567) selected a sleep study provider from 5 options, with manipulations including financial responsibility, provision of price information, and a prosocial message encouraging high-value options.

RESULTS: Price transparency increased the selection of lower-cost options among participants who were solely responsible for paying for …

The Ever-Present Nature Of Christ In The Title Of Jehovah, Dan Belnap

Faculty Publications

In January 2000 the First Presidency and the Quorum of the Twelve Apostles of The Church of Jesus Christ of Latter-day Saints bore testimony to the world of the reality, humanity, and divinity of Jesus Christ in a document titled “The Living Christ: The Testimony of the Apostles.” Among its many truths was the following: “He [Christ] was the Great Jehovah of the Old Testament.”1 Though this was not the first time Church leadership had declared Christ to be Jehovah, the pronouncement does reemphasize this teaching. It also emphasizes the centrality of Christ in the Old Testament. In fact, the …

Redesigning Executive Incentives: The Rising Role Of Subjective Performance Measures, Zackery D. Fox

Faculty Publications

Despite the growing use of subjective performance incentives used in executive bonuses, empirical evidence on their effectiveness remains inconclusive. This study explores three aspects of subjective metrics in bonus plan design: their prevalence, the goals they target, and their impact on managerial behavior and firm outcomes. First, I document 53.8 percent of CEO bonus plans include at least one subjective performance measure, and among these plans, an average of 38.9 percent of total bonus weight is allocated to these measures. Using machine learning, I show subjective metrics target incentives related to employees, firm culture, and executive performance. Second, using the …

From Hospital Discharge To Long-Term Care: Unmet Rehabilitation Needs In Cauda Equina Syndrome Patients From A National Uk Cohort, Uces Collaborators, British Neurosurgical Trainee Research Collaborative, Holly Roy, Krithika Anil, Jack Read, Marcus J. Drake, Ingrid Hoeritzauer, Julie Woodfield

Peninsula Medical School

Objectives: Although long term disability may be a consequence of cauda equina syndrome (CES), the evidence base for the effect of rehabilitation or different rehabilitation strategies is lacking. Our aim was to understand long term neurological deficits (understood as rehabilitation needs) and current rehabilitation provision for patients with CES. Methods: We retrospectively analysed data from a large UK wide cohort of CES patients presenting between 1st June 2018 and 31st May 2019. Rehabilitation referrals and attendance were described, and symptoms at discharge and one year were identified as potential targets for rehabilitation. Results: Physiotherapy was the most common inpatient rehabilitation …

Sulfur Cycling In The Gabbroic Section Of The Oman Ophiolite, Ana P. Jesus, Harald Strauss, Mário A. Gonçalves, Michelle Harris, Diogo Silva, Martin J. Whitehouse, Damon A.H. Teagle

School of Geography, Earth and Environmental Sciences

We present sulfur mineralogy and isotope geochemistry from the gabbro transect of the Oman Drilling Project to unravel the sulfur cycle during hydrothermal alteration of the plutonic oceanic crust. The sheeted dike–gabbro transition (Hole GT3A) shows low sulfide‑sulfur concentrations (GT3A_median = 178 ppm, σ = 4873 ppm) but with great sulfur isotope variability (δ³⁴S = −12.8 to 14.4 ‰ V-CDT, weighted average + 5.8 ‰) and unusually heavy compositions relative to in-situ or ophiolitic crust. These features are consistent with abiogenic thermochemical sulfate reduction during intense hydrothermal alteration under greenschist facies conditions which formed a low-variance and …

New Insights Into Active Tectonics And Landscape Evolution Of The Northernmost Chilean Central Depression, A. Vega-Ruiz, P. Victor, K. Reicherter, A. Binnie, L. Evenstar, G. González, S. A. Binnie

School of Geography, Earth and Environmental Sciences

Active deformation and landscape evolution in North Chilean forearc involve multiscale tectonic processes, such as crustal thickening causing orogenic-scale uplift and faulting modulating the mountain-front landscape. In the Central Depression, faults redirecting Quaternary drainages are poorly understood due to their subtle surface expressions and limited structural data acquisition. To address this, we combined remote-sensing analysis of high-resolution DEMs, satellite and UAV imagery, new geomorphic mapping, structural data, and morphometric analysis with available surface age dating to identify and give temporal constraints on previously unmapped faults impacting drainages across this region. Our findings reveal the reactivation of east-vergent NNW-SSE reverse to …

Relationships Between Sediment Size Distribution And Microplastic Abundance And Characteristics Along The Strandline Of A Sandy Embayment (Whitsand, Southwest England), Oliver J. Fenn, Edward J. Walklett, Andrew Turner

School of Geography, Earth and Environmental Sciences

Beach sediments taken from 1 m² areas of strandline across an embayment in southwest England (Whitsand) have been analysed for grain size distribution and elemental content. Large (1–5 mm) and small (< 1 mm) microplastics were isolated by sieving and flotation in NaBr solution, respectively, and characterised by size, shape, colour and polymeric makeup. Sediments displayed varying median diameters and degrees of sorting but distributions were always positively skewed. Concentrations of Fe, K, Mn and Ti were relatively invariant, but Ca concentrations exhibited heterogeneous distributions across the bay. Large microplastics were largely composed of polyolefin-based pre-production pellets, bio-beads and fragments whose numbers were correlated with each other. Positive and inverse relationships between beads and sediment skewness and sorting, respectively, suggests that deposition of this type of plastic is favoured where sediment is well-sorted and contains a high proportion of fine material. Small microplastics were dominated by fragments and fibres <200 μm in size composed of a broader array of polymers (including epoxy resin, polyetherimide and polyvinyl alcohol). Fibres exhibited an inverse relationship with bead and pellet abundance but there was no evidence of dependency on grain size distribution, and their presence is attributed to entrapment in interstitial spaces between sediment grains. Compositional differences between large (1–5 mm) and small (< 1 mm) microplastic fragments suggests they are derived from different sources, with the former coupled with pellet and bead deposition and the latter small enough to be retained in interstitial spaces with fibres. However, a positive relationship between mean (small) fragment size and median sediment diameter suggests that their retention is more constrained by interstitial space than fibres. The study provides evidence that microplastics of different size and shape behave differently but are, ultimately, related to or controlled by sediment size distribution in the coastal littoral zone.

The State Of Temperate Rainforest In South West England, Thomas Murphy, Katerina Chernyuk, Marcin Roszkowski, Shaun Lewin, Paul Lunt, James Buckley

School of Geography, Earth and Environmental Sciences

Temperate Rainforest is a biome of global significance which is rare and declining, yet supports endemic biodiversity and offers a range of co-benefits including carbon sequestration, natural flood management, climate moderation, and human well-being. The UK hosts a very large proportion of European bioclimatic space suitable for the development of Temperate Rainforest, yet very little of this woodland remains. In SW England, Temperate Rainforest habitat is mostly dominated by oak woodland (NVC communities W11 and W17) and occupies a broad but fragmented distribution across the region. SW temperate rainforest is exposed to a range of current and future threats and …

Field Learning And Employability In Geography, Earth, And Environmental Sciences, Jacqueline Dohaney, Alison Stokes

School of Geography, Earth and Environmental Sciences

Society needs talented Geography, Earth and Environmental Sciences (GEES) graduates to help address global challenges, but the pathway to professional employment is seldom easy. After graduation, most GEES graduates enter professions requiring broad transferable skills and 'value-added' experiences to thrive in the modern workforce. GEES educators can therefore enhance employability by using field experiences to introduce and develop transferable skills valued by employers. Here, we define employability for our context, explore GEES graduate skills and describe the ways that communication, project management and personal and professional skills can be embedded in field experiences guided by the available literature. We identify …

Arctic Fjord Ecosystem Adaptation To Cryosphere Meltdown Over The Past 14,000 Years, Jochen Knies, Youngkyu Ahn, Berenice Ebner, Lukas Smik, Kwangchul Jang, Seung Il Nam, Simon T. Belt, Carsten J. Schubert

School of Geography, Earth and Environmental Sciences

The Arctic cryosphere is the epicentre of acute global change impact, with abrupt warming and amplification driving rapid sea ice decline and irreversible glacial ice loss. A key challenge is understanding how the cryosphere meltdown will impact Arctic marine carbon cycles and ecosystems. Here, we use organic geochemical biomarkers to trace the contribution of different planktonic groups to organic carbon in Arctic fjord sediments (Kongsfjorden, Svalbard) during past warmer and colder (than present) climate states. We show that phytoplankton community structures changed abruptly with variable sea ice cover and glacial ice loss. Our results imply that future deglaciation of Svalbard …

Conservation Planning For Promoting Ecosystem Service Provisioning Outside Protected Area Networks, Florence Godfrey Tarimo, Francis Moyo, Claire Kelly, Linus Kasian Munishi

School of Geography, Earth and Environmental Sciences

Among factors that contribute to global biodiversity loss, habitat loss through unsustainable land use and land cover changes has gained prominence, with impacts being exacerbated by increasing human populations. Establishing protected area networks (PANs) is strongly advocated by national and international mechanisms, such as the Convention on Biological Diversity (CBD), as a primary strategy to guide biodiversity conservation and management; however, this can undermine conservation efforts outside protected areas. Understanding how people and biodiversity overlap and interact outside protected area networks (OPAN areas) is essential for setting realistic, sustainable targets to guide biodiversity conservation and ecosystem service provision beyond PAN. …