Digital Commons Network^™

Investigating Potential Therapeutic Vulnerabilities And Elucidating Molecular Mechanisms For The Tumor Suppressors Nfkbia And Anxa7 In Diffuse Gliomas, Aran Merati

All ETDs from UAB

Gliomas, and especially diffuse gliomas, can be a devastating disease when attempting treatment in the clinic. Diffuse gliomas are typically malignant and pose definitive problems with respect to patient care predominantly due to their ability to exist outside of the bulk tumor by invading into the surrounding brain parenchyma. Consequently, not every cancerous cell can be fully removed by surgical resection and therapeutic resistance, so the stem-like population left behind can repopulate a recurrent tumor from a single cell. There is a desperate need for pinpointing novel therapeutic vulnerabilities in diffuse gliomas, which could potentially involve the targeting of key …

Maternal Immune Activation Causes Oligodendrocyte Deficits In The Hypothalamus, Kate Miller

All ETDs from UAB

Maternal immune activation (MIA) refers to the occurrence of an inflammatory immune response during any stage of pregnancy. This manifests as the upregulation of proinflammatory cytokines and can be caused by air pollution, obesity, or viral infection. When this occurs during the first trimester in humans, it increases the offspring’s susceptibility to developing neuropsychiatric disorders such as autism (ASD) and schizophrenia (SZ), in males more commonly than females. In addition to behavioral manifestations of neuropsychiatric disorders, metabolic syndrome (MetS) is a common comorbidity, defined as the co-occurrence of three or more symptoms including but not limited to hyperlipidemia, hypertension, and …

Reducing Stress: The Role Of The Rcl Operon In Bacterial Stress Response To Hypothiocyanite, Julia Meredith

All ETDs from UAB

The human immune system utilizes a variety of weapons against bacterial communities within the body, which allow it to control the overall microbial population. Understanding how some bacterial species are able to better deal with and survive damage by the immune system while others are not, can help us elucidate the complex relationship between us and our microbiome. One tool that immune cells use for microbial control is the potent oxidant hypothiocyanite/hypothiocyanous acid (-OSCN/HOSCN). The response mounted by Escherichia coli and other bacterial species in order to survive damage caused by HOSCN is the focus of this dissertation. In the …

Understanding Submerged Plant Microbiome And Exploring Plant Microbe Interaction Through Plasma Optimization Studies, Binoop Mohan

All ETDs from UAB

The master's thesis presents research on enhancing plant resilience and growth through the study of the microbiome of submerged aquatic plants and the application of plasma technology in agriculture. We isolated 177 endophytic microbial strains from submerged plants collected from various locations. Screening revealed 50 strains producing ACC deaminase, an enzyme that mitigates plant stress by reducing ethylene levels. Predominant genera included Pseudomonas, Bacillus, and Acinetobacter. Metagenomic analysis characterized the diverse bacterial communities associated with these plants. Different plasma treatments were tested to optimize their effects on plant growth. Atmospheric jet and globe plasma treatments significantly improved root length and …

An Investigation Into The Effects Of Preservatives On Ss-Hydroxybutyrate Concentrations Measured By Commercial Ketone Meter And Gas Chromatography-Mass Spectrometry, Kerry F. Murr

All ETDs from UAB

Ketoacidosis occurs when fatty acids are metabolized into ketone bodies in the liver and released into the bloodstream. This condition, which can be fatal, is commonly observed in diabetics, alcoholics, and individuals who experienced starvation or hypothermia. Although the ketone ß-hydroxybutyrate (BHB) is an accepted biomarker of ketoacidosis, the effects of preservatives on BHB concentrations in postmortem blood are unaddressed. The first aim of this research was to determine whether preservatives affect ketone levels as measured by a point-of-care device. Paired preserved and unpreserved blood samples were obtained from the Jefferson County morgue: preserved samples in grey top tubes and …

Exploring The Impact Of Returning To Office Work Post-Pandemic On The Mental Health Of Workers: A Cross-Sectional Analysis, Jasmine M. Nelson

All ETDs from UAB

This study examines the association between work settings and mental health outcomes among Black working-aged women, with a focus on racial disparities and the role of self-care. Using data from the U.S. Census Bureau's 2024 Household Pulse Survey, this cross-sectional analysis includes responses from 196,293 employed women aged 18–65. Mental health outcomes, including anxiety, worry, lack of interest, and depressive symptoms—were assessed through self-reported measures. Work settings were categorized as telework (hybrid/remote) or in-office, and logistic regression models were used to assess associations between work setting and mental health outcomes, adjusting for demographic and socioeconomic factors. Findings indicate that Black …

Therapeutic Implications Of Fractionated Radiotherapy And Marcks’ Regulation Of Tunneling Nanotubes In Glioblastoma, Lauren Catherine Nassour-Caswell

All ETDs from UAB

Glioblastoma (GBM) is the most common primary brain malignancy in adults and the gradual development of treatment resistance prevents patients from achieving remission. A primary objective in the field is to devise strategies to overcome this. We predicted this could be achieved by improving existing therapies, creating better models to study GBM, and by identifying a potential therapeutic target. Fractionated radiotherapy (RT) has been used in GBM standard of care for over a century but does not account for GBM heterogeneity. We first hypothesized that in silico mathematical modeling would be a useful tool for cytotoxicity prediction. While this model …

Exploring Gaps In Hiv Prevention: Hiv Pre-Exposure Prophylaxis Awareness, Attitudes, Utilization, Coverage, Hiv Testing And Risk Perception Among Sub-Saharan African College Students In The United States, Ikenna Obasi Odii

All ETDs from UAB

This dissertation focuses on increasing HIV awareness and contributing to efforts at reducing new HIV infections among Sub-Saharan African (SSA) college students. It begins with an introductory chapter one and ends in the concluding chapter five. Chapter two presents a systematic review identifying key gaps in HIV Pre-Exposure Prophylaxis (PrEP) knowledge, attitudes, and utilization among Black college students in the United States (U.S). The review synthesizes findings from four studies, revealing that a third of participants demonstrated adequate PrEP knowledge, while PrEP utilization remained under-utilized at three percent. Key barriers to PrEP uptake included fear, low self-perceived HIV risk, infrequent …

Environmental Exposure To Metals In Children And Their Effects On Autism Spectrum Disorder, Oludesola Ogunesan

All ETDs from UAB

ABSTRACT As scientific understanding of environmental determinants of health advances, growing attention has turned to the role of toxic metal exposures in exacerbating neurodevelopmental outcomes, particularly in vulnerable populations such as children with autism spectrum disorder (ASD). This dissertation investigates the intersection of environmental metal exposure, biomonitoring innovation, and social factors shaping ASD severity in Alabama. Using a multidisciplinary framework, four interrelated studies explore biological, environmental, and participatory dimensions of ASD research and public health. The first study evaluates the utility of Volumetric Absorptive Microsampling (VAMS) for measuring exposure to cadmium (Cd), chromium (Cr), lead (Pb), manganese (Mn), and mercury …

Investigating Risk Of Suboptimal Hiv Treatment Outcomes (Treatment Failure And Disengagement) Among Pregnant And Postpartum Women Living With Hiv, Kevin Owuor

All ETDs from UAB

The joint United Nations Programme on HIV/AIDS (UNAIDS) has set targets to end the HIV epidemic by improving HIV diagnosis, treatment, and viral suppression to reduce new infections and improve health outcomes for people living with HIV (PLHIV), including pregnant and postpartum women living with HIV (PPWH). After diagnosis, linking PPWH to antiretroviral (ART) treatment is critical to suppress the virus and prevent mother-to-child transmission (MTCT) of HIV. Continuous engagement in care is essential for achieving and maintaining virologic suppression in the peripartum and postpartum period for PPWH, both for their own health and the health of their family. Disengagement …

Precision Imaging For Head And Neck Tumors, Logan Daniel Stone

All ETDs from UAB

Antibody-based imaging modalities have become more common in the field of imaging oncology as more biomarkers are identified for certain cancers. Epidermal growth factor receptor (EGFR) is overexpressed in several cancer types including head and neck squamous cell carcinoma (HNSCC) and ameloblastoma (AB). The over- expression in these cancers has been targeted with antibodies such as Panitumumab and Cetuximab for imaging modalities. These antibodies can be conjugated with IRDye800 molecules for intraoperative fluorescence imaging or radiolabel for pre-operative positron emission tomography/ computed tomography (PET/CT) imaging. These agents could provide surgeons with additional exams to identify carcinoma in scenarios where only …

"It Says Mommy’S Coffee!": Environmental Print As A Tool To Support Young Children’S Emergent Literacy And Family Engagement In Early Care And Education, Melissa Dawn Sudduth

All ETDs from UAB

This study addressed topics related to family engagement in early childhood education, emergent literacy skills, and the use of environmental print (EP) to support young children’s emergent literacy. The children of interest in this study were young children between the ages of birth and 5-years enrolled in licensed, private early care and education (ECE) centers in Alabama. The researcher employed an explanatory sequential mixed methods design using a quantitative survey and qualitative interviews to address the following mixed methods questions: How do families of young children perceive family engagement?, Which emergent literacy skills do families of young children value and …

Sex Differences In The Development Of T-Bet+ B Cells In Lupus, Kathryn A. Sullivan

All ETDs from UAB

Cardinal features of lupus include elevated B cell activation and autoantibody production with a female sex preponderance. Development of T-bet+ B cells, driven by aberrant TLR7 and interferon (IFN) signaling, is a key pathogenic feature of systemic lupus erythematosus (SLE). In the present study, we developed two novel approaches to elucidate the mechanisms of female sex predisposition to lupus. We (i) quantified interactions of sex and genetic variation on the development of autoimmune B-cell phenotypes and autoantibodies in the BXD2 murine model of lupus using a cohort of backcrossed progeny (BXD2 x C57BL/6J) x BXD2; (ii) used a combination approach …

Parsing Clinical And Neurobiological Heterogeneity In First-Episode Psychosis Patients With And Without Features Of The Deficit Syndrome Of Schizophrenia, Matheus Teles Gomes De Araujo

All ETDs from UAB

Schizophrenia is highly heterogeneous in its neurobiological and clinical presentations, which hinders attempts to understand its pathophysiology, limits efforts to identify biomarkers, and deters optimal patient care. A way to parse clinical heterogeneity is to subtype patients based on clinical presentations. The deficit syndrome (DS) is a possible subtype, characterized by primary and enduring negative symptoms. Evidence for neurobiological abnormalities dissociating DS from other forms of schizophrenia is inconsistent as most studies do not account for heterogeneity within patient groups due to limitations of group-level comparisons. The question remains whether DS presents a unique and less heterogeneous neurobiological phenotype. The …

Radioactive Seed Localization For The Resection Of Nonpalpable Breast Lesions, Katherine Ward

All ETDs from UAB

Accurate localization of malignant tissues is critical in breast cancer treatment to ensure effective therapy while minimizing damage to surrounding healthy tissues. Radioactive seed localization, specifically using Iodine-125 (I-125), is a prominent method due to its precision and minimally invasive nature. However, this technique poses a risk of radiation exposure to adjacent healthy tissues. This study aims to quantify the radiation dose to healthy breast tissue from I-125 seed implantation by employing two distinct computational approaches: a hemisphere breast model in MATLAB and Monte Carlo simulations in Mathematica. The American Association of Physicists in Medicine (AAPM) Task Group 43 (TG- …

An Examination Of Sleep Quality And Experimental Pain Sensitivity In People With Hiv And Insomnia, Caroline Kathryn Webb

All ETDs from UAB

Prior research has established a bidirectional relationship between sleep and pain, yet this relationship has been understudied in people living with HIV. The current study investigated the relationship between HIV status (H+/H-) and insomnia status (I+/I-) on sleep and quantitative sensory testing (QST) variables. The study was comprised of two research visits where participants were screened and completed the QST protocol. Participants completed the Insomnia Severity Index (ISI), Dysfunctional Beliefs and Attitudes about Sleep (DBAS), and actigraphy as subjective and objective measures of sleep. There were four groups: H-/I- (n=46), H-/I+ (n=37), H+/I- (n=14), and H+/I+ (n=39) (N=136). Results showed …

Exploring Environmental Health Awareness And Knowledge In 9th – 12th Grade Students: A Mixed Methods Approach, Crystal Stephens

All ETDs from UAB

EXPLORING ENVIRONMENTAL HEALTH AWARENESS AND KNOWLEDGE IN 9TH – 12TH GRADE STUDENTS: A MIXED METHODS APPROACH CRYSTAL T. STEPHENS ENVIRONMENTAL HEALTH SCIENCES ABSTRACT Safe environments provide accessibility and community protections preventing residents from exposure to contaminants or facing health risks. Unfortunately, environmental exposures such as air pollution and neighborhood-level concerns can adversely impact human health. Environmental justice communities are overburdened with increased adverse environmental exposures and subsequent health disparities. Adolescents may be more vulnerable to exposure risks and provide an opportunity to introduce environmental health education. With their power of peer association and determination, adolescents can influence the health and …

Dosimetric Comparison Of Different Imrt Vs Vmat Planning Techniques In The Treatment Of Peripheral Brain Tumors., Ahmed A. Hammad, Mohamed S. Ibrahim, Ayman M. Ibrahim, Magdy M. Khalil

Trends in advanced sciences and technology

Introduction This study aims to investigate and compare different IMRT and VMAT treatment planning techniques in peripheral brain tumors. Materials and Methods A total of 15 previously treated cases of peripheral brain tumors were selected and replanned with different techniques using a prescribed dose of 54 Gy in 30 fractions. Five different techniques: 5-field IMRT, 7-field IMRT, 9-field IMRT, 1-Half Arc VMAT, and 2-Half Arc VMAT, were systematically assessed. Evaluation was conducted based on dose-volume Histogram (DVH) metrics for both planning target volumes (PTVs) and organs at risk (OARs). Key parameters analyzed included the mean and maximum doses (Dmean and …

Irisin And Bdnf Mediate Exercise And Melatonin Effects In Animal Model Of Experimental Hypothyroid Depression., Hanan Essam Mohamed, Mf El-Bab, Noha O. Shawky, Nermien E. Waly

Trends in advanced sciences and technology

Background Depression affects about 60% of people with hypothyroidism. Exercise and melatonin are thought to have beneficial effects in hypothyroid depression. Irisin and brainderived neurotrophic factor (BDNF) participate significantly in hypothyroid depression in rats and both are decreased in hypothyroid depression. Objectives To investigate the potential roles of melatonin and exercise in hypothyroid depression. Methodology Fifty-six male albino rats were divided into eight groups (n=7/group) as follows: Control (C), Hypothyroidism (Hypo), Hypothyroidism and Melatonin 10 mg/kg/day (Mel), treated hypothyroidism with Levothyroxine 20 μg/kg/day and Melatonin (Mel&Levo), Hypothyroidism and Exercise (30-minute swimming protocol, 5 days/week) (Ex), treated hypothyroidism and exercise (Ex&Levo), …

Clinical Trials Unit Newsletter - Issue 01, Clinical Trials Unit (Ctu)

Clinical Trials Unit (CTU) Archives

• What's inside this issue:
• AKU receives JCIA reaccreditation - Clinical Trials Unit rejoice
• Director’s Message
• Informative Snippets
• AKU Site Surpasses Target Sample Size in the D-LIVR Global Trial
• Clinical Trials Unit celebrates World Pharmacists Day
• WHO Delegation at the Clinical Trials Unit Keynote Address at RMI's Symposium
• Impact Report - Covid-19 Studies
• Impact Snapshot for the year 2024

Reimagining Coach Evaluations: High School Athletic Directors' Perspectives On Program Evaluation Practices, Ashley Gerome

Master of Education in Applied Human Development Graduate Projects

High school athletic programs increasingly face the challenge of ensuring coaches not only are technically proficient but also how well the coaches support their student-athletes’ personal growth, well-being, and development. As traditional, performance-focused evaluation models fall short in addressing these broader goals, there is a growing need for more effective, holistic approaches to coaching evaluation. This study explores how athletic leadership is evolving to meet that need, focusing on the shift from results-driven metrics to athlete-centered, developmental evaluation practices. Though interviews with seven athletic directors to understand how coaching experience, professional identity, and evaluation methods affect leadership and program growth. …

A Design For Teaching Strength And Conditioning In High School Physical Education: Curriculum Development, Kamren Mullican

Master of Education in Applied Human Development Graduate Projects

This project was developed out of an interest in providing an example of a flexible, evidence-based curriculum for teaching strength and conditioning in high school physical education. Rather than viewing the weight room as simply a place for exercise, the curriculum presented here positions strength and conditioning as a structured, safe, and standards-aligned instructional component of physical education. It is designed to be organized and adaptable across a variety of high school physical education settings.

The Ultimate Sport Agent, Chidiebere Anugwolu

Master of Education in Applied Human Development Graduate Projects

My earliest interest to become a sports agent was sparked during my four years of work with the Badminton Federation of Nigeria between 2019 - 2022. But even then, I could not say that I really understood what it meant to be called a “Sport Agent”. As the media lead for Badminton Nigeria, I worked closely with national team athletes where I performed media related responsibilities and some marketing. Since the sport of Badminton was not a very lucrative sport, I observed first hand some of the funding challenges the athletes faced to either travel abroad for training tours or …

Swing Into Strength: A Golfers' Guide To Bodyweight Exercise, William Welker

Master of Education in Applied Human Development Graduate Projects

The purpose of this guide is to improve your overall fitness which can potentially lead to better sport performance. Golf is a sport that is continuing to grow in popularity. More people are playing the sport than ever, and people are looking for different ways to get an edge against their opponents. Not everyone has the time to go to the course and spend hours at the driving range or short game area, so it is worthwhile to learn other ways you can get results. If you are not regularly engaging in exercise, then following this guide will serve as …

The Impact Of Social Media Engagement On Fan Loyalty In Professional Sports, Duane Bartnicki

Master of Education in Applied Human Development Graduate Projects

Social media has become an essential tool for communication and interaction in the sports industry, transforming how teams connect with their fans. Platforms like X (formerly Twitter), TikTok, Facebook, and Instagram offer dynamic spaces for teams to share content, engage directly with followers, and build online communities. For professional sports organizations, the ability to foster engagement with fans is crucial. It not only enhances the fan experience but also plays a significant role in driving loyalty. It gives organizations an opportunity to understand the motivations, loyalty, and relationships of their fan base through insights gained from social media (Kaya and …

Effect Of Trade Openness On Food Security In Economic Community Of West African States Region, Yahaya Umar Isah, Ikubor, Ofili Jude, Bernard, O. A., Zakari Saheed S., Ayodeji, S.

DLSU Business & Economics Review

This study investigates the impact of trade openness on food security in the ECOWAS trade zone. The study relied on the system GMM approach to analyze the impact of trade openness on overall and disaggregated components of food security in the ECOWAS trade zone during the period 2014 and 2021. Annual time series data were sourced from the Food and Agriculture Organization, World Bank Metadata base, and World Integrated Trade Solution. Major findings from the study reveal that trade openness has a significant positive impact on overall food security indicators. However, trade openness has not significantly impacted food availability and …

The Global Value Chain Effects Of Rcep: Estimating The Impact On The Philippines, Caesar B. Cororaton

DLSU Business & Economics Review

This paper extends the global CGE model results of Cororaton (2022) by disaggregating further the RCEP trade creation effects on the Philippines into global value chain (GVC) impacts. The GVC analysis indicates that the trade agreement in RCEP results in higher Philippine exports of US$ 2.8 billion in 2031, of which the increase in Philippine domestic value added is US$ 2.4 billion, significantly higher than the foreign value added of US$ 403 million. Electronic products contribute 67% of the value added generated within the Philippines. The increase in the import contents of Philippine exports is only US$ 413 million. Furthermore, …

Saints And Syncretism In Global Christian Art, Alexandra Lewis, Andie Near, Charles Mason, Gracie Allen, Signe Bieganski, Shannon Smith, Emma Waldvogel, Lauren Carpenter, Ashley Keltsch, Sophia Funston, Mariam Tiews, Emma Brenny, Anne Heath

Kruizenga Art Museum Exhibition Catalogs

Kruizenga Art Museum, Hope College Catalog for the exhibition: Saints and Syncretism in Global Christian Art. Exhibition dates: January 14 – May 17, 2025. Alexandra Lewis, photographer, designer. Andie Near, photographer.

Kruizenga Art Museum Online Collection - Exhibition Gallery

Atomic Physics For Everyone: An Introduction To Atomic Physics, Quantum Mechanics, And Precision Spectroscopy With No College-Level Prerequisites, Will Raven

Open Educational Resources: Textbooks

This open access textbook introduces beginning undergraduate students and high school students to the world of quantum mechanics and atomic spectroscopy. Requiring no previous knowledge of physics and no math beyond basic algebra and sines and cosines, this book focuses on concepts to make the excitement of atomic physics more accessible for learners than ever before. It comes replete with learning goals, exercises and solutions, and an optional experimental component, making this text readily adoptable for both the classroom and the undergraduate lab. The book takes the reader on a lively and engaging tour through topics at the forefront of …

The Prize Biter Of Modernity? Investigating Killer Whale Bite Mechanics, Daniel Hong

West Chester University Graduate Theses, Dissertations, and Final Projects

Although the killer whale (Orcinus orca) is a cosmopolitan apex predator, very little work has been done on its feeding biomechanics. Here I use finite element analysis to investigate the mandibular stiffness of a juvenile male Bigg’s killer whale, and compare it to that of the false killer whale (Pseudorca crassidens) and the saltwater crocodile (Crocodylus porosus). Full mandibles and left and right halves of mandibles are simulated under FEA. I also estimate the total jaw muscle force produced by the Bigg’s killer whale using the dry skull method. The killer whale lacks an …