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2025

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Psychosocial Behavioral Phenotypes Of Racially/Ethnically Minoritized Older Adults Enrolled In Habs-Hd Differ On Neuroimaging Measures Of Brain Age Gap, Hippocampal Volume, And Cortical Thickness, Alexandra L Clark, Makenna B Mcgill, Alexandra J Weigand, Julie K Wisch, Kalen Petersen, Beau Ances, Meredith N Braskie, Sid O'Bryant, Kelsey R Thomas, Habs‐Hd Study Team Jan 2025

Psychosocial Behavioral Phenotypes Of Racially/Ethnically Minoritized Older Adults Enrolled In Habs-Hd Differ On Neuroimaging Measures Of Brain Age Gap, Hippocampal Volume, And Cortical Thickness, Alexandra L Clark, Makenna B Mcgill, Alexandra J Weigand, Julie K Wisch, Kalen Petersen, Beau Ances, Meredith N Braskie, Sid O'Bryant, Kelsey R Thomas, Habs‐Hd Study Team

2020-Current year OA Pubs

INTRODUCTION: This study examined whether previously identified psychosocial behavioral phenotypes differed on structural neuroimaging markers.

METHODS: Latent profile analysis (LPA) employed in a sample of 1820 community-dwelling older adults (1118 Hispanic and 702 Black) replicated previous Low Resource/Low Distress, High Resource/Low Distress, and Low Resource/High Distress phenotype classifications. Analyses of covariance (ANCOVAs) adjusting for relevant factors examined phenotype differences on neuroimaging outcomes of predicted brain age gap (BAG) (DeepBrainNet

RESULTS: The Low Resource/Low Distress and Low Resource/High Distress phenotypes had significantly higher predicted BAGs relative to the High Resource/Low Distress phenotype, and the Low Resource/High Distress group displayed significantly lower …


Proceedings Of The 12th Annual Deep Brain Stimulation Think Tank: Cutting Edge Technology Meets Novel Applications, Alfonso Enrique Martinez-Nunez, Nico U F Dosenbach, Evan M Gordon, Et Al. Jan 2025

Proceedings Of The 12th Annual Deep Brain Stimulation Think Tank: Cutting Edge Technology Meets Novel Applications, Alfonso Enrique Martinez-Nunez, Nico U F Dosenbach, Evan M Gordon, Et Al.

2020-Current year OA Pubs

The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology. Innovative applications are currently being explored in stroke, disorders of consciousness, and sleep, while established treatments for movement disorders like Parkinson's disease are being refined with adaptive stimulation. Neuromodulation is solidifying its role in treating psychiatric disorders such as depression and obsessive-compulsive disorder, particularly for …


Association Of Item-Level Responses To Cognitive Function Index With Tau Pathology And Hippocampal Volume In The A4 Study, Idris Demirsoy, Elham Ghanbarian, Babak Khorsand, Bhargav T Nallapu, Kellen K Petersen, Richard B Lipton, S Ahmad Sajjadi, Laura A Rabin, Ali Ezzati Jan 2025

Association Of Item-Level Responses To Cognitive Function Index With Tau Pathology And Hippocampal Volume In The A4 Study, Idris Demirsoy, Elham Ghanbarian, Babak Khorsand, Bhargav T Nallapu, Kellen K Petersen, Richard B Lipton, S Ahmad Sajjadi, Laura A Rabin, Ali Ezzati

2020-Current year OA Pubs

INTRODUCTION: Alzheimer's disease (AD) has a long preclinical phase in which individuals may accumulate amyloid beta (Aβ) and tau pathology without noticeable cognitive impairment. Subjective cognitive impairment reports can provide early insights into cognitive decline.

METHODS: In the A4 Study, 339 cognitively unimpaired, Aβ-positive individuals underwent tau positron emission tomography imaging. Tau status was classified based on medial temporal lobe tau standardized uptake value ratios (tau

RESULTS: Higher tau

DISCUSSION: These findings support the utility of participant- and study partner-reported concerns as early indicators of preclinical AD pathology, with potential value for early detection and trial enrichment strategies.

HIGHLIGHTS: Higher …


Multidisciplinary Approach To Treating Complex Immune Dysregulation Disorders: An Adaptive Model For Institutional Implementation, Lauren A Henderson, Megan A Cooper, Anthony French, Et Al. Jan 2025

Multidisciplinary Approach To Treating Complex Immune Dysregulation Disorders: An Adaptive Model For Institutional Implementation, Lauren A Henderson, Megan A Cooper, Anthony French, Et Al.

2020-Current year OA Pubs

Patients with immune dysregulation may present with varying combinations of autoimmunity, autoinflammation, immunodeficiency, atopy, lymphoproliferation, and/or malignancy, often with multisystem involvement. Recognizing specific patterns of immune dysregulation, coordinating and interpreting complex diagnostic testing, and choosing initial (often empiric) treatment can be challenging. Centers are increasingly assembling multidisciplinary teams (MDTs) to standardize evaluation and optimize treatment of patients with complex immune dysregulation (immune dysregulation MDTs [immMDTs]). However, published information on the composition and function of immMDTs is sparse, and there is little guidance for those seeking to establish or optimize an immMDT. To inform this review, we assembled a panel of …


Sensorimotor Faculties Bias Choice Behavior, Jan Kubanek, Lawrence H Snyder, Richard A Abrams Jan 2025

Sensorimotor Faculties Bias Choice Behavior, Jan Kubanek, Lawrence H Snyder, Richard A Abrams

2020-Current year OA Pubs

Decision-making is a deliberate process that seemingly evolves under our own volition. Yet, research on embodied cognition has demonstrated that higher-order cognitive processes may be influenced, in unexpected ways, by properties of motor and sensory systems. Here we tested whether and how decisions are influenced by handedness and by asymmetries in the auditory system. Right- and left- handed participants performed an auditory decision task. In the task, subjects decided whether they heard more click sounds in the right ear or in the left ear, and pressed a key with either their right or left index finger, according to an instructed …


Defining Knowledge Gaps In Preterm Birth Research: Can Biomarkers Fill The Gaps?, Scott M Williams, Kevin P Rosenblatt, Sandra Reznik, Dawn P Misra, Shajila Siricilla, Nardhy Gomez-Lopez, Brandie D Taylor, Kristina M Adams Waldorf, Ramkumar Menon, Prebic North America 2024 Jan 2025

Defining Knowledge Gaps In Preterm Birth Research: Can Biomarkers Fill The Gaps?, Scott M Williams, Kevin P Rosenblatt, Sandra Reznik, Dawn P Misra, Shajila Siricilla, Nardhy Gomez-Lopez, Brandie D Taylor, Kristina M Adams Waldorf, Ramkumar Menon, Prebic North America 2024

2020-Current year OA Pubs

Preterm birth (PTB) is a syndrome arising from multiple etiologies that manifest as a final common phenotype, delivery before full term. Current knowledge gaps in epidemiologic, basic science, and clinical fields have limited our understanding of this complex pregnancy syndrome. Lack of insight into the cellular and molecular pathways underlying spontaneous PTB (PTB) has thus limited effective clinical management and restricted the investigation of novel treatments or druggable targets. Here, we examine several areas of domain-driven research that may lead to a better understanding of PTB, including infection and inflammation that drive early labor, social factors and their biological consequences …


"I Feel Like People Would Look At Me Like I'M Dirty Or Like I'M A Thief:" A Qualitative Exploration Of Interpersonal And Intrapersonal Experiences That Influence Recovery Among Adults At Risk Of Opioid-Related Overdose, Hannah S Szlyk, Sara Jones, Jordan Michener, Zhuoran Zhang, Nina Kaiser, Heidi Holtz, Melody Rachel Konadu Frempong, Husain Lateef, William Hutson, Patricia Cavazos-Rehg Jan 2025

"I Feel Like People Would Look At Me Like I'M Dirty Or Like I'M A Thief:" A Qualitative Exploration Of Interpersonal And Intrapersonal Experiences That Influence Recovery Among Adults At Risk Of Opioid-Related Overdose, Hannah S Szlyk, Sara Jones, Jordan Michener, Zhuoran Zhang, Nina Kaiser, Heidi Holtz, Melody Rachel Konadu Frempong, Husain Lateef, William Hutson, Patricia Cavazos-Rehg

2020-Current year OA Pubs

OBJECTIVE: Due to the nature of early termination of treatment and the transient lifestyles of many people who use substances, many providers are unaware of the factors that may have contributed to their client's engagement in treatment. Treatment providers and researchers need a better understanding of intrapersonal and interpersonal factors that impact recovery from the clients' perspective. This study uses qualitative methods to explore these factors.

METHODS: Eligible participants were adults who had used opioids and/or stimulants and were receiving treatment at a consenting facility. Participants completed one-month follow-up interviews after using a mobile health intervention. Transcripts were analyzed using …


Barriers And Facilitators To Implementing A Task-Sharing Mental Health Intervention For Sickle Cell Disease Populations In Low- And Middle-Income Countries: A Qualitative Analysis Using The Consolidated Framework For Implementation Research (Cfir), John Patena, Leah Elster, Tania Hameed, Sumedha Kulkarni, Alden Yuanhong Lai, Annika C Sweetland, Joyce Gyamfi, Temitope Ojo, Angela Odoms-Young, Charmaine Royal, Emmanuel Peprah Jan 2025

Barriers And Facilitators To Implementing A Task-Sharing Mental Health Intervention For Sickle Cell Disease Populations In Low- And Middle-Income Countries: A Qualitative Analysis Using The Consolidated Framework For Implementation Research (Cfir), John Patena, Leah Elster, Tania Hameed, Sumedha Kulkarni, Alden Yuanhong Lai, Annika C Sweetland, Joyce Gyamfi, Temitope Ojo, Angela Odoms-Young, Charmaine Royal, Emmanuel Peprah

2020-Current year OA Pubs

BACKGROUND: People living with Sickle Cell Disease (SCD) experience higher rates of common mental disorders (CMD). There is an alarming treatment gap in the provision of adequate mental health services for CMDs in low- and middle-income countries (LMIC). One solution is the implementation of task-sharing interventions such as the Friendship Bench which utilizes concepts of problem-solving therapy (PST). This investigation uses a qualitative study design to evaluate the acceptability and feasibility of implementing a PST-based task-sharing mental health intervention for SCD populations in LMICs using the Consolidated Framework for Implementation Research (CFIR).

METHODS: Purposive, convenience, and snowball sampling strategies were …


Emergency Department Utilization Among Youth In Foster Care: Benefits Of A Patient-Centered Medical Home, Nicholas Szoko, Allison Phad, Mary E Fournier, George M Hoganson, Melissa Jonson-Reid Jan 2025

Emergency Department Utilization Among Youth In Foster Care: Benefits Of A Patient-Centered Medical Home, Nicholas Szoko, Allison Phad, Mary E Fournier, George M Hoganson, Melissa Jonson-Reid

2020-Current year OA Pubs

BACKGROUND: Foster youth face unique medical, psychological, and social challenges, which can impact patterns of emergency department (ED) utilization. The patient-centered medical home (PCMH) offers a potential model to reduce overutilization of healthcare resources. Little work has examined relationships between PCMHs and ED utilization among foster youth.

OBJECTIVES: We sought to describe longitudinal trends in ED utilization among foster youth in a PCMH.

METHODS: This retrospective cohort study leveraged electronic health record data from foster youth seen in a PCMH from 2018 to 2024. Frequency of ED utilization was calculated before, during, and after involvement in the PCMH. We used …


Perspectives Of Key Stakeholders On Integrating Wearable Sensor Technology Into Rehabilitation Care: A Mixed-Methods Analysis, Allison E Miller, Carey L Holleran, Marghuretta D Bland, Ellen E Fitzsimmons-Craft, Caitlin A Newman, Thomas M Maddox, Catherine E Lang Jan 2025

Perspectives Of Key Stakeholders On Integrating Wearable Sensor Technology Into Rehabilitation Care: A Mixed-Methods Analysis, Allison E Miller, Carey L Holleran, Marghuretta D Bland, Ellen E Fitzsimmons-Craft, Caitlin A Newman, Thomas M Maddox, Catherine E Lang

2020-Current year OA Pubs

INTRODUCTION: Rehabilitation is facing a critical practice gap: Patients seek out rehabilitation services to improve their activity in daily life, yet recent work demonstrates that rehabilitation may be having a limited impact on improving this outcome due to lack of objective data on patients' activity in daily life. Remote monitoring using wearable sensor technology is a promising solution to this address this gap. The purpose of this study was to understand patient and clinician awareness of the practice gap and preferences for integrating wearable sensor technology into rehabilitation care.

METHODS: This study used a mixed-methods approach consisting of surveys and …


Barriers And Facilitators Of Integrating Cervical Cancer Screening Into Routine Hiv Care And Acceptability Of Self-Sampling For Hpv Dna Testing Among People With Hiv: An Exploratory Study In Southern Ghana, Evelyn Yayra Bonney, Emmanuel Frimpong Gyekye, Jonathan Klutse, Dzidzor Aku Attoh, Yeena Abla Tay, Nicholas Ekow Thomford, Mary Amoakoh-Coleman, Kwadwo Ansah Koram, George Boateng Kyei, Collins Stephen Ahorlu Jan 2025

Barriers And Facilitators Of Integrating Cervical Cancer Screening Into Routine Hiv Care And Acceptability Of Self-Sampling For Hpv Dna Testing Among People With Hiv: An Exploratory Study In Southern Ghana, Evelyn Yayra Bonney, Emmanuel Frimpong Gyekye, Jonathan Klutse, Dzidzor Aku Attoh, Yeena Abla Tay, Nicholas Ekow Thomford, Mary Amoakoh-Coleman, Kwadwo Ansah Koram, George Boateng Kyei, Collins Stephen Ahorlu

2020-Current year OA Pubs

BACKGROUND: Cervical cancer poses a substantial global health challenge, disproportionately affecting low- and middle-income nations. Women living with HIV are disproportionately affected compared to the general population. Our study explored the acceptance and preferences of participants regarding cervical cancer screening procedures during their HIV clinic visits.

METHODS: Using the Consolidated Framework for Implementation Research (CFIR) to inform questions, we conducted semi-structured in-depth qualitative interviews with 85 people with HIV (PWH), across six southern Ghana sites, to identify factors that could promote or impede the integration of cervical cancer screening into HIV care in Ghana. We also explored the acceptability of …


Hydroxyurea Utilization Among Individuals With Sickle Cell Disease In Tennessee: A Pooled Analysis Of Claims Data, Ayesha Mukhopadhyay, Matthew P Smeltzer, Judy Dudley, Sherif M Badawy, Joacy G Mathias, Allison P Plaxco, Meredith A Ray, Andrew D Wiese, Walter I Stevens, James G Gurney, Chinonyelum Nwosu, Jerlym S Porter, Lisa M Klesges, Jane S Hankins, William O Cooper Jan 2025

Hydroxyurea Utilization Among Individuals With Sickle Cell Disease In Tennessee: A Pooled Analysis Of Claims Data, Ayesha Mukhopadhyay, Matthew P Smeltzer, Judy Dudley, Sherif M Badawy, Joacy G Mathias, Allison P Plaxco, Meredith A Ray, Andrew D Wiese, Walter I Stevens, James G Gurney, Chinonyelum Nwosu, Jerlym S Porter, Lisa M Klesges, Jane S Hankins, William O Cooper

2020-Current year OA Pubs

IMPORTANCE: Hydroxyurea reduces severe disease among individuals living with sickle cell disease (SCD). These individuals experience high acute care utilization, but the associations between patterns of hydroxyurea utilization and healthcare utilization are not well investigated.

OBJECTIVE: This study aimed to determine the association between hydroxyurea use and healthcare utilization among individuals with SCD in Tennessee (TN).

DESIGN: We conducted a population-based, retrospective cohort study of individuals with SCD using secondary data analysis of Tennessee Medicaid, Medicare, and BlueCross BlueShield of Tennessee (BCBS-TN).

PARTICIPANTS: A total of 4,901 individuals with SCD were included in the study.

EXPOSURE: Hydroxyurea adherence was estimated …


Building Capacity For Hiv And Implementation Science Among Students In The United States: The Stimulating Training And Access To Hiv Research Experiences (Star) Program, Ucheoma Nwaozuru, Onyekachukwu Anikamadu, Alexis Engelhart, David Oladele, Bryce Puesta Takenaka, Olufunto A Olusanya, Temitope Ojo, Juliet Iwelunmor, Et Al. Jan 2025

Building Capacity For Hiv And Implementation Science Among Students In The United States: The Stimulating Training And Access To Hiv Research Experiences (Star) Program, Ucheoma Nwaozuru, Onyekachukwu Anikamadu, Alexis Engelhart, David Oladele, Bryce Puesta Takenaka, Olufunto A Olusanya, Temitope Ojo, Juliet Iwelunmor, Et Al.

2020-Current year OA Pubs

BACKGROUND: Expanding HIV research capacity among the global majority (individuals identifying as Black/African American, American Indian and Alaska Native, Asian, Native Hawaiian and Other Pacific Islander, Multiracial, and Hispanic/Latino) is important. However, achieving national goals to increase the pool of implementation science and HIV early-stage investigators from underrepresented backgrounds remains elusive, largely due to limited investment in training and mentoring these individuals. To address this issue, we launched the Stimulating Training and Access to HIV Research Experiences (STAR) program, a partnership led by Saint Louis University and the University of North Carolina at Chapel Hill in collaboration with Georgia State …


Usability Of The Mayo Test Drive Remote Self-Administered Web-Based Cognitive Screening Battery In Adults Aged 35-100 With And Without Cognitive Impairment, Jay S Patel, Jason Hassenstab, Et Al. Jan 2025

Usability Of The Mayo Test Drive Remote Self-Administered Web-Based Cognitive Screening Battery In Adults Aged 35-100 With And Without Cognitive Impairment, Jay S Patel, Jason Hassenstab, Et Al.

2020-Current year OA Pubs

BACKGROUND: Mayo Test Drive (MTD): Mayo Test Development through Rapid Iteration, Validation and Expansion, is a web-based remote cognitive assessment platform for self-administered neuropsychological measures with previously demonstrated validity and reliability. We examined the usability of MTD and hypothesized that completion rates would be greater than 90%. We explored whether completion and participation rates differed by cognitive status and demographic factors.

METHODS: A total of 1,950 Mayo Clinic Study of Aging and Mayo Alzheimer's Disease Research Center participants (97% White, 99% Non-Hispanic) were invited to participate in this ancillary, uncompensated remote study. Most invitees were cognitively unimpaired (CU;

RESULTS: Baseline …


An Exploratory Graphical Analysis Of The Montgomery-Åsberg Depression Rating Scale Pre- And Post-Treatment Using Pooled Antidepressant Trial Secondary Data, David Byrne, Arunangshu Ghoshal, Fiona Boland, Susan Brannick, Robert M Carney, Pim Cuijpers, Alexandra L Dima, Kenneth E Freedland, Suzanne Guerin, David Hevey, Bishember Kathuria, Vincent Mcdarby, Emma Wallace, Frank Doyle Jan 2025

An Exploratory Graphical Analysis Of The Montgomery-Åsberg Depression Rating Scale Pre- And Post-Treatment Using Pooled Antidepressant Trial Secondary Data, David Byrne, Arunangshu Ghoshal, Fiona Boland, Susan Brannick, Robert M Carney, Pim Cuijpers, Alexandra L Dima, Kenneth E Freedland, Suzanne Guerin, David Hevey, Bishember Kathuria, Vincent Mcdarby, Emma Wallace, Frank Doyle

2020-Current year OA Pubs

BACKGROUND: The 10-item Montgomery-Åsberg Depression Rating Scale (MADRS) is a commonly used measure of depression in antidepressant clinical trials. Numerous studies have adopted classical test theory perspectives to assess the psychometric properties of this scale, finding generally positive results. However, its network configural structure and stability is unexplored across different time-points and treatment groups.

AIMS: To assess the network structure and stability of the MADRS in clinical settings pre- and post-treatment, and to determine a configurally invariant and stable model across time-points and treatment groups (placebo and intervention).

METHOD: Individual participant data for 6440 participants from 14 clinical trials of …


Examining Mental And Sexual Health Themes In Latina Youth Zines: A Multi-Modal Content Analysis, Jenn M. Lilly, D'Andrah Almanzar, Doreen Dorcely, Luisa Fernanda Sandoval Cortes, Ana Iris Murcia Jan 2025

Examining Mental And Sexual Health Themes In Latina Youth Zines: A Multi-Modal Content Analysis, Jenn M. Lilly, D'Andrah Almanzar, Doreen Dorcely, Luisa Fernanda Sandoval Cortes, Ana Iris Murcia

Social Service Faculty Publications

Multiple, convergent risk factors place Latina youth at disproportionate risk for mental

and sexual health issues. Yet, their firsthand perspectives and experiential knowledge of

how to navigate mental and sexual health challenges is rarely the subject of scholarly

inquiry. This article presents a multi-modal content analysis of themes and messages

conveyed by two digital zines created by Latina young adults for Latina teens through an

arts-based research project. In this arts-based research, zines functioned as both data and

method, capturing Latina youth’s nuanced perspectives and lived experiences of mental

and sexual health. We identified six themes in their works—acknowledging and …


Influence, Confidence, And Interest In Mathematics: The Route To Increasing Female Participation In Stem, Lisa Galbreath Neaton Black Jan 2025

Influence, Confidence, And Interest In Mathematics: The Route To Increasing Female Participation In Stem, Lisa Galbreath Neaton Black

Theses and Dissertations

Women are underrepresented in STEM professions despite initiatives to encourage young women to pursue these financially rewarding careers. Studies show this divide is not due to inability or lack of female participation in higher education, as women tend to outscore their male counterparts on standardized tests and make up approximately 59% of the postsecondary student population. Rather, the disconnect in the high school-to-college STEM pipeline for young women seems to center on mathematics. In response, this action research study focused on addressing societal influence and mathematical confidence and interest using a constructivist approach in an honors Algebra 2 class.Hands-on activities, …


Factors Influencing Adherence To Surveillance Guidelines In Individuals With Tuberous Sclerosis Complex, Kashish Khanna Jan 2025

Factors Influencing Adherence To Surveillance Guidelines In Individuals With Tuberous Sclerosis Complex, Kashish Khanna

Theses and Dissertations

Tuberous Sclerosis Complex (TSC) is a genetic condition that is caused by pathogenic changes in either the TSC1 or TSC2 gene and is characterized by multiple benign tumors, otherwise known as hamartomas, in various organs such as the brain, skin, lungs, and kidneys. Because of the many different clinical manifestations of TSC, extensive surveillance guidelines are recommended for individuals with TSC. Past studies have shown that there has been a gap in knowledge of these surveillance guidelines. These studies also suggest projects that measure adherence to surveillance guidelines and address specific challenges hindering surveillance guideline adherence. This study aims to …


The Effects Of Schema Therapy On Shame In Victims Of Intimate Partner Violence, Annette Ibarra Skeen Jan 2025

The Effects Of Schema Therapy On Shame In Victims Of Intimate Partner Violence, Annette Ibarra Skeen

Theses and Dissertations

Intimate partner violence (IPV) is prevalent in the United States and worldwide. Despite the deleterious effects of IPV on personal and societal wellness, there is limited research on effective interventions for IPV victims. Among the detrimental effects of IPV on mental health, shame is a common emotion experienced by IPV victims. Shame can contribute to an array of mental health concerns, such as depression, anxiety, low self-esteem, PTSD, substance abuse, and suicidality. Using a multiple baseline, singe case design, the aim of the current study was to evaluate the effects of Schema Therapy (ST) on shame on IPV victims. Based …


The Relationship Between Cardiac Patient Beliefs And Experiences With Insurability And Their Decisions On Whether Or Not To Pursue Genetic Testing, Julia Schoeni Jan 2025

The Relationship Between Cardiac Patient Beliefs And Experiences With Insurability And Their Decisions On Whether Or Not To Pursue Genetic Testing, Julia Schoeni

Theses and Dissertations

Since the enactment of the Genetic Information Non-Discrimination Act (GINA) in 2008, genetics providers have been incorporating conversations about GINA in pre-test counseling. There is currently limited evidence of the effects of personal or family histories of cardiomyopathy or aortopathy and associated genetic testing on patients seeking insurance policies not protected by GINA, including life, long term care, and disability insurance. This study aimed to determine whether individuals with a personal or family history of cardiomyopathy or aortopathy are having conversations about future insurability with their healthcare providers and how they perceive their ability to get these insurances when deciding …


Utilizing Evisits To Increase Access To Genetic Services For The Hearing Loss Population: A Tailored Service Delivery Model, Ansley Roberts Jan 2025

Utilizing Evisits To Increase Access To Genetic Services For The Hearing Loss Population: A Tailored Service Delivery Model, Ansley Roberts

Theses and Dissertations

Purpose: Patients referred for genetics services have specific barriers decreasing accessibility, such as communication difficulties, long wait times, and misconceptions about the utility of genetic testing. We assessed a new tailored service delivery model used by the Greenwood Genetic Center to evaluate patients referred for hearing loss to determine if this model increases access to genetics services for individuals with hearing loss. Methods: Data points such as wait times, testing plan, and diagnostic yield were compiled from patient medical records. Comparison and analysis of data was completed by visit type, in-person, virtual, and electronic visits (eVisits), between October 2023 – …


“Digital Shame Shift”: From Telling The Pain To Recording The Truth — Black Maternal Health And Digital Counter-Narrative Storytelling On Tiktok, Odera Covenant Ezenna Jan 2025

“Digital Shame Shift”: From Telling The Pain To Recording The Truth — Black Maternal Health And Digital Counter-Narrative Storytelling On Tiktok, Odera Covenant Ezenna

Theses and Dissertations

This dissertation explores how digital storytelling on TikTok is used to challenge medical racism, with a particular focus on Black maternal health. Guided by Critical Race Theory (CRT) and Critical Technocultural Discourse Analysis (CTDA), the study examines how TikTok users—ranging from Black mothers to healthcare professionals—create and circulate counter-narratives through two prominent campaigns: #BlackMaternalHealthWeek and #BlackMamasMatter. These digital stories serve as acts of resistance, disrupting dominant medical discourse and amplifying the lived experiences of Black birthing individuals. The research analyzes over 2900 TikTok videos posted between 2021 and 2024, identifying key themes, storytelling strategies, and rhetorical shifts over time. The …


Involvement Of Integrated Stress Response In Primary And Secondary Dystonia, Tricia Aleena Dulice Simon Jan 2025

Involvement Of Integrated Stress Response In Primary And Secondary Dystonia, Tricia Aleena Dulice Simon

Theses and Dissertations

ABSTRACT Dystonia is the third most common movement disorder in the United States of America , the first two being essential tremor and Parkinson’s disease. Gaining mechanistic knowledge about pathobiology of dystonia is essential for development of effective therapies. As the only therapies currently available are invasive procedures such as deep brain stimulation (DBS) or frequent botulinum toxin injections, it is critical to understand the underlying molecular mechanisms leading to dystonia. A maladaptive integrated stress response (ISR) involving dysregulation of the eukaryotic translation initiation factor  (eIF2) mediated signaling is observed in DYT-PRKRA patient cells. Mutations in PRKRA gene, which …


Secondary Ell Students’ Perception Of Ell And Stem Courses And Its Impact On Enrollment In Stem Courses, Prakash Patel Jan 2025

Secondary Ell Students’ Perception Of Ell And Stem Courses And Its Impact On Enrollment In Stem Courses, Prakash Patel

Theses and Dissertations

This action research study examined experiences of eight secondary-level English Language Learners (ELL) that lead to perceptions of being in ELL and STEM courses and how those perceptions impact academic pathways in subsequent course enrollment, specifically STEM courses. The study aimed to identify secondary level ELLs’ lived experiences while concurrently enrolled in ELL and STEM courses through the use of a mixed-methods explanatory sequential design to capture specific lived experiences that promote enrollment in STEM courses through intrinsic motivation. The study employed the use of ClassMaps (CMS) (Doll et al., 1999) and the Intrinsic Motivation Inventory (IMI) (CSDT, 2025) surveys …


The Gut-Brain Axis: Investigating The Effects Of Diet, Physical Activity, And Prior Adversity On Anxiety Via Autonomic Nervous System, Jenna L. Pennella Jan 2025

The Gut-Brain Axis: Investigating The Effects Of Diet, Physical Activity, And Prior Adversity On Anxiety Via Autonomic Nervous System, Jenna L. Pennella

UNF Graduate Theses and Dissertations

Previous literature has highlighted a bidirectional relationship between the gut and brain called the gut-brain axis (de Punder & Pruimboom, 2015; Hill et al., 2008; Leistner & Menke, 2020). The current study aimed to investigate directional relations between different stressors (e.g. poor diet, vigorous activity, and prior adversity) and anxiety and how interactions with gut issues and autonomic dysfunction may impact these relationships. Based on previous literature, we examined (a) physical activity and diet as moderators of stress and anxiety as well as stress and GI symptoms, (b) GI symptoms as a mediator between various predictors (i.e., diet, stress, physical …


The Role Of Parental Self-Efficacy During The Preschool Years: Links To Parenting Behaviors And Parent-Child Relationship Quality In Dual-Risk Families, Catalina M. Borges Jan 2025

The Role Of Parental Self-Efficacy During The Preschool Years: Links To Parenting Behaviors And Parent-Child Relationship Quality In Dual-Risk Families, Catalina M. Borges

UNF Graduate Theses and Dissertations

Parental self-efficacy (PSE) has been shown to play a critical role in shaping parenting behaviors and parent-child interactions. Examining whether domain-specific PSE like parental self-efficacy helping the child succeed in school (PSEHCSS), influences broad parenting behaviors and parent-child relationships is especially important for families experiencing elevated stress. This secondary analysis explored whether PSEHCSS predicted parenting behaviors and parent-child relationship quality over the preschool years in dual-risk families (i.e., low socioeconomic status and a child with developmental concerns). It was hypothesized that higher PSEHCSS would predict more positive and fewer negative parenting behaviors, and greater parent-child relationship quality; parenting behaviors would …


The Cultural Mechanisms Of Mental Health Stigma In Asian Americans, Vaishnavi Suren Jan 2025

The Cultural Mechanisms Of Mental Health Stigma In Asian Americans, Vaishnavi Suren

UNF Graduate Theses and Dissertations

Asian Americans show hesitation seeking professional mental health services, as well as stigmatized attitudes towards help-seeking for mental health treatment in general. While the link between this stigma and lack of help-seeking is clear in past studies, there is a gap in the literature in looking at how various cultural mechanisms important to traditional Asian cultures interact with one another to contribute to mental health stigma. The goal of the current study was to examine intergenerational conflict, saving face, and temporal orientation to predict mental health stigma among Asian Americans. Participants (N = 208) were all second-generation Asian American …


A Pilot Study Of The Freeze Response: Physiological Markers Under Threat Versus Safety Video Conditions, Ula Mccarthy Jan 2025

A Pilot Study Of The Freeze Response: Physiological Markers Under Threat Versus Safety Video Conditions, Ula Mccarthy

UNF Graduate Theses and Dissertations

This pilot study examined physiological markers of the human freeze response during exposure to threat and safety-based video stimuli. The freeze response is an adaptive defense mechanism characterized by reduced heart rate and heightened sympathetic arousal (Roelofs, 2017; Hagenaars et al., 2014; Sagliano et al., 2014; Hermans et al., 2013). 20 university students were randomly assigned to view either a threatening or safety-based video clip while heart rate and electrodermal activity (EDA) were recorded using Biopac Bionomadix wireless systems. Trauma severity and PTSD symptomatology were assessed through validated self-report measures (BTQ; Schnurr et al., 1999), (PCL-5; Weathers et al., 2013). …


Retrospective Recall Of Food Parenting Practices During Childhood, Current Adult Health Outcomes, And Intuitive Eating, Katelyn Bretzel Jan 2025

Retrospective Recall Of Food Parenting Practices During Childhood, Current Adult Health Outcomes, And Intuitive Eating, Katelyn Bretzel

UNF Graduate Theses and Dissertations

Emerging adulthood is a time of exploration, change, and emerging independence, which can make individuals vulnerable to health changes. Previous research demonstrates that food parenting practices (coercive control, structure, and autonomy support) during childhood may relate to health outcomes into adulthood. In the current study, it was hypothesized that intuitive eating during emerging adulthood would be associated with food parenting practices; with coercive control and structure practices hindering intuitive eating, while autonomy support encourages it. The current study tested these relationships further, utilizing retrospective reports of food parenting practices during childhood and examining their relation to intuitive eating, dietary quality, …


Severe Aggression Among Zoo-Housed Coconut (Trichoglossus Haematodus) And Rainbow (Trichoglossus Moluccanus) Lorikeets: Wellbeing Considerations For Free-Flight Aviaries, Emily Simkins Jan 2025

Severe Aggression Among Zoo-Housed Coconut (Trichoglossus Haematodus) And Rainbow (Trichoglossus Moluccanus) Lorikeets: Wellbeing Considerations For Free-Flight Aviaries, Emily Simkins

UNF Graduate Theses and Dissertations

As conservation and education institutions, modern zoos balance the needs of animals with the interests of visitors through several strategies which can increase animal wellbeing and improve visitor experience. Environmental enrichment is frequently employed to increase the suitability of anthropogenic environments for zoo-housed animals, such as through walkthrough habitats and free-flight aviaries. While habitats such as these are important for visitor experience and can be enriching to animals, there are also wellbeing considerations for these spaces. Walkthrough habitats can be a potential source of fear and stress for animals, as shown by increased frequencies of vigilance, undesirable behavior, and aggression. …