Digital Commons Network^™

Revolutionizing The Immaculate Conception: The Limitations Of Medieval Theology And The Advancements Of John Duns Scotus, Emily G. Knoppe

Graduate Theses/Dissertations

Although in the modern era, the Immaculate Conception is a controversial doctrine that prompts conflict primarily between Catholic and non-Catholic groups, during the medieval period Roman Catholics were greatly divided on the topic. Opposition to the belief hinges not only on its lack of scriptural basis and complicated theology, which some deem as placing Mary outside of the need for Christ’s redemption, but also on the fact that it was not declared dogma until 1854 by Pope Pius IX. In this thesis, I first consider how Augustine of Hippo’s original sin theology laid the foundation for avid rejection of the …

From The Battlefield To The Asylum: The Social Construction Of Disability In Italy, 1900 - 1950, Brandie Crisp Robb

Graduate Theses/Dissertations

The Italian social construction of disability reflects a complex interplay between social, religious, political, and religious influences present during the first half of the twentieth century. While Western European and American disability discourse remained similar, those influences unique to Italy resulted in the formation of two distinct disability discourses during the early twentieth century: that of the heroic physically disabled veteran who sacrificed everything for the good of Italy, and the eugenically unfit Italian associated with dependency and uselessness. By combining a theoretical framework that includes critical disability theory with historical methodology, the following thesis demonstrates how the emerging disability …

Synthesis And Characterization Of Doped Rare-Earth Zinc Alloys, Partha Das

Graduate Theses/Dissertations

Rare-Earth-Zinc (RE-Zn) alloys doped with manganese represent a promising class of materials with diverse applications in magnetic, electronic, and thermoelectric devices. These alloys hold significant potential owing to the unique combination of rare-earth elements' properties with the versatility of zinc, augmented by manganese doping. In this study, I present the successful synthesis of ErMn_0.2Zn_11.8 alloys, achieved through self-flux method. The synthesized crystals were characterized using electron dispersive spectroscopy (EDS) and single crystal X-ray diffraction (XRD). Additionally, magnetic measurements were performed to investigate the magnetic properties. Future plans include DFT calculations and comparison study between Rare-Earth-Zinc alloys with …

Livelihood Adaptive Strategies And Marginalization In Decision-Making: A Study Of Glacial Lake Outburst Flood (Glof) Vulnerable Communities In Northern Pakistan, Sobia Shah

Graduate Theses/Dissertations

This study examines livelihood adaptation strategies and the dynamics of marginalization in decision-making within communities vulnerable to Glacial Lake Outburst Floods (GLOFs) in Gilgit-Baltistan, Northern Pakistan. Grounded in a vulnerability framework encompassing exposure, sensitivity, and adaptive capacity, it addresses two objectives: identifying household and community-level adaptation strategies to GLOF risks and analyzing structural drivers of marginalization in adaptation decision-making. A mixed-methods design was used, combining a systematic review of GLOF measures in the Hindu Kush Himalaya (HKH) region with a household survey of 150 respondents in Hassanabad and Hoper valleys. Generalized Additive Models (GAMs) assessed how socio-demographic, economic, institutional, and …

Association Of Item-Level Responses To Cognitive Function Index With Tau Pathology And Hippocampal Volume In The A4 Study, Idris Demirsoy, Elham Ghanbarian, Babak Khorsand, Bhargav T Nallapu, Kellen K Petersen, Richard B Lipton, S Ahmad Sajjadi, Laura A Rabin, Ali Ezzati

2020-Current year OA Pubs

INTRODUCTION: Alzheimer's disease (AD) has a long preclinical phase in which individuals may accumulate amyloid beta (Aβ) and tau pathology without noticeable cognitive impairment. Subjective cognitive impairment reports can provide early insights into cognitive decline.

METHODS: In the A4 Study, 339 cognitively unimpaired, Aβ-positive individuals underwent tau positron emission tomography imaging. Tau status was classified based on medial temporal lobe tau standardized uptake value ratios (tau

RESULTS: Higher tau

DISCUSSION: These findings support the utility of participant- and study partner-reported concerns as early indicators of preclinical AD pathology, with potential value for early detection and trial enrichment strategies.

HIGHLIGHTS: Higher …

Resilience Of The Gut Microbiome To Short Proton Pump Inhibitor Therapy With Or Without High-Dosage L Reuteri In H Pylori-Infected Adults, Stefano Bibbò, Gustav Ahlström, Giovanni Mario Pes, David Y Graham, Lars Engstrand, Elettra Merola, Maria Pina Dore

Faculty, Staff and Students Publications

Background: Helicobacter pylori eradication therapy typically consists of a combination of antibiotics and an antisecretory drug. Probiotics may be added to reduce side effects and possibly improve outcomes.

Materials and methods: We conducted a double-blind, randomized trial of pantoprazole plus either Lactobacillus reuteri (Gastrus) (high dose) or a matching placebo to assess the impact on the gut microbiota of H. pylori-positive adults. Fecal samples were collected at baseline and after one and 2 months for shotgun metagenomic sequencing.

Results: A total of 26 patients were recruited and completed therapy. L. reuteri was only detected in the group that received supplemental …

In Code We Trust: Blockchain’S Decentralization Paradox, Sangita F. Gazi

Vanderbilt Journal of Entertainment & Technology Law

This Article explores blockchain technology’s decentralization and governance challenges. It interrogates the tension between the idea of a trustless, decentralized economy at the core of blockchain’s promise and the realities of power concentration and information asymmetry. Examining the ramifications of the Crypto Winter of 2022 on trust and governance within the blockchain ecosystem, the Article also underscores a critical paradox within blockchain ecosystems. It argues that despite the foundational ethos of decentralization and open participation, the governance structures of major blockchain networks manifest significant centralization, challenging the narrative of an egalitarian, user-driven evolution. The current state of blockchain’s centralities fundamentally …

Netchoice, Regulatory Competition, And The Real Battle Behind Social Media Regulations, Tao Huang, Assistant Professor Of Law

Vanderbilt Journal of Entertainment & Technology Law

Regulating online social media platforms has been a fiercely debated issue for years. The NetChoice case decided by the US Supreme Court 2023 Term arises from a circuit split regarding Florida and Texas laws that regulate social media content moderation. Most discussions on regulation of social media content moderation have focused on whether social media platforms are speakers (editors) or carriers (conduits), and whether their moderation practice constitutes editorial judgment (i.e., protected speech). This Article argues that this framing of the debate ignores another more important role of social media platforms—as regulators. Platforms, when they enact and enforce their content …

And The Two Shall Become One: Conceptualizing The Right Of Publicity As The Nexus Of Trademark And Copyright Law, Alvin Zhang, J.D. Candidate

Vanderbilt Journal of Entertainment & Technology Law

The right of publicity, which bars the unauthorized commercial use of a celebrity’s likeness, has become increasingly important in recent years. As generative artificial intelligence (AI) threatens to replace singers’ voices and actors’ appearances on screen, people are increasingly looking to the right of publicity to protect entertainers from exploitation.

Defining the right of publicity, however, is notoriously difficult. Since the right overlaps with both trademark and copyright law, circuit courts are currently split over whether to apply the trademark-based Rogers test or the copyright-based transformative use test.

This Note, in addressing this split, proposes a legal framework under which …

Trouble, Trouble, Trouble: Taylor Swift, Ticketmaster, And Arbitration, Imre S. Szalai Professor Of Social Justice

Vanderbilt Journal of Entertainment & Technology Law

Through Ticketmaster’s use of arbitration and the controversy surrounding Ticketmaster’s botched sale of tickets for Taylor Swift’s The Eras Tour, this Article explores problems with the broad use of arbitration in the United States. Arbitration, a private contractual method of resolving disputes in a binding manner, is a neutral process that can provide many benefits. However, under the current broad scope of arbitration law, virtually every type of claim can be arbitrated. A more limited arbitration law could provide more robust enforcement of laws, greater accountability and transparency, and stronger development of precedent within our legal system. Stronger parties (like …

Sensory Processing And Anxiety In Bipolar Disorder, Lyric Arvizu

Graduate Theses/Dissertations

Past research suggests that individuals with bipolar disorder often experience differences in sensory gating and sensory processing, and similar patterns have been observed in anxiety disorders. Given that anxiety is highly comorbid with bipolar disorder, the present study examined how these conditions relate to self-reported sensory processing differences. A total of 132 participants (88 female), including 43 with bipolar disorder, were included in the final sample. Anxiety symptomatology was measured via the State-Trait Anxiety Inventory (STAI) Form Y. Sensory processing questionnaires included the Sensory Gating Inventory (SGI) and the Adult Sensory Processing Scale (ASPS). Correlations, t-tests, a multivariate analysis of …

Deepseek: Another Step Forward In The Diagnosis Of Oral Lesions, Márcio Diniz-Freitas, Pedro Diz-Dios

Journal of Dental Sciences

Abstract Artificial intelligence (AI) is increasingly being explored as a tool for medical diagnosis, particularly in fields with limited specialized training, such as oral medicine. This study evaluates the performance of DeepSeek-R1, an open-source large language model (LLM), in diagnosing oral diseases and conditions using text-based case descriptions from the New England Journal of Medicine's “Image Challenge.” Results indicate that DeepSeek-R1 achieved a diagnostic accuracy of 91.6 %, slightly outperforming ChatGPT-4o (88.9 %) and significantly exceeding the 47.8 % accuracy of the journal’ readers. While DeepSeek lacks direct image interpretation capabilities, it demonstrates high proficiency in textual diagnostic tasks. These …

Limitations Of Bibliometric Analysis: Evidences From Trigeminocardiac Reflex Published In Journal Of Dental Sciences, Li-Chiu Yang, Michelle Chao, Yu-Chao Chang

Journal of Dental Sciences

No abstract provided.

Stamper, Thomas Jefferson - Volume 2, Carter County Genealogical Society, Betty Stamper Wellman

Carter County Genealogy Collection

Genealogy of Thomas Jefferson Stamper Sr. family in Carter County, Kentucky.

Thomas is the eighth child of John R. 'Pewter John' and Sarah 'Sallie' Stamper

Simulation Model To Estimate Pretreatment (Baseline) Low-Density Lipoprotein Cholesterol Levels In People Living With Homozygous Familial Hypercholesterolemia, Jing Gu, Robert J Sanchez, Alexandra Koumas, Sandeep Tripathi, Harshit Dixit, Adam Amer, Laurence Sperling, Christie M Ballantyne

Faculty, Staff and Students Publications

Introduction: Pretreatment levels of low-density lipoprotein cholesterol (LDL-C) are a primary consideration for the clinical diagnosis of homozygous familial hypercholesterolemia (HoFH). However, determination of pretreatment LDL-C can be challenging in this population because many individuals begin lipid-lowering therapy (LLT) early in life before diagnosis of HoFH.

Methods: A previously developed simulation model was adapted to estimate pretreatment LDL-C in people living with HoFH, based on their treated LDL-C value and current LLT (statin, ezetimibe, alirocumab, evolocumab, and/or lipoprotein apheresis).

Results: The tool includes an interface for users to provide relevant details for estimating non-clinical pretreatment LDL-C, specifically for patients suspected …

Mechanosensitivity Of Macrophage Polarization: Comparing Small Molecule Leukadherin-1 To Substrate Stiffness, Hemant Joshi, Edgar Anaya, Anvitha Addanki, Alison Almgren-Bell, Elizabeth M Todd, Sharon Celeste Morley

2020-Current year OA Pubs

Macrophages sustain tissue homeostasis through host defense and wound repair. To promote host defense, macrophages upregulate surface markers associated with antigen processing and secrete pro-inflammatory mediators such as IL-6 and IL-1β. After pathogen clearance, macrophages shift phenotype to promote wound repair. Shifts in phenotypes are termed "polarization" and have historically been modeled by exposure to soluble mediators such as LPS+IFNγ (host defense) or IL-4+IL-13 (tissue repair). Greater emphasis is now being placed on understanding how the mechanical environment of macrophages, such as tissue compliance, regulates macrophages responses. Here, we compare incubation of primary macrophages on collagen-coated silica gels of varying …

Visual Outcomes In A Series Of Patients With Papilledema And Comorbid Nutritional Deficiency, Dan V Spiegelman, John Burkland, Evan Jameyfield, Gregory P Van Stavern, Leanne Stunkel

2020-Current year OA Pubs

BACKGROUND: Fulminant papilledema is a neuro-ophthalmologic emergency that can lead to permanent vision loss as a result of optic neuropathy. Despite appropriate treatment of intracranial hypertension and improvement of papilledema, some patients continue to experience worsening vision. In some cases, comorbid micronutrient deficiencies, which are an additional cause of optic neuropathy, may contribute to this decline. This case series highlights patients with papilledema whose vision worsened despite improvement in papilledema and who were found to have comorbid nutritional deficiencies.

METHODS: A retrospective case series of three patients with papilledema were seen between 2019 and 2022 at Washington University in St. …

Incidence And Outcomes Of Hospitalized Acute Ischemic Stroke Patients With Subsequent St-Segment-Elevation Myocardial Infarction, Arhum Mahmood, Song Peng Ang, Yusuf Kamran Qadeer, Hafeez Ul Hassan Virk, Jonathan Alan Tangsrivimol, Iqra Riaz, Zhen Wang, Mahboob Alam, Markus Strauss, Chayakrit Krittanawong

Faculty, Staff and Students Publications

Background: Patients admitted with acute ischemic stroke (AIS) may experience accompanying acute ST-Segment myocardial infarction after AIS. The cardiovascular risks, incidence, complications, and outcomes of acute STEMI in patients hospitalized with AIS remains underexplored.

Methods: We evaluated 2,804,819 patients that presented with AIS who were listed in the National Inpatient Sample from 2016 to 2021. AIS and STEMI were defined according to the ICD-10 Diagnostic Codes. Patients with Non-STEMI were excluded. The risk of specific complications and outcomes were expressed as percentages. Multivariable logistic regression analysis was used to examine the association of STEMI with a primary outcome of mortality …

The Clinical Genome Resource (Clingen): Advancing Genomic Knowledge Through Global Curation, Clingen Consortium

Faculty, Staff and Students Publications

The Clinical Genome Resource (ClinGen) is a National Institutes of Health-funded program founded 10 years ago that defines the clinical relevance of genes and variants for medical and research use. ClinGen working groups develop standards for data sharing and curating genomic knowledge. Expert panels, with >2500 active members from 67 countries, curate the validity of monogenic disease relationships, pathogenicity of genetic variation, dosage sensitivity of genes, and actionability of gene-disease interventions using ClinGen standards, infrastructure, and curation interfaces. Results are available on clinicalgenome.org and classified variants are also submitted to ClinVar, a publicly available database hosted by the National Institutes …

Central Obesity Is An Independent Determinant Of Advanced Fibrosis In Lean Patients With Nonalcoholic Fatty Liver Disease, Arka De, Naveen Bhagat, Manu Mehta, Priya Singh, Sahaj Rathi, Nipun Verma, Sunil Taneja, Madhumita Premkumar, Ajay Duseja

Faculty, Staff and Students Publications

Background: The current definition of lean is based on body mass index (BMI). However, BMI is an imperfect surrogate for adiposity and provides no information on central obesity (CO). Hence, we explored the differences in clinical profile and liver disease severity in lean patients with nonalcoholic fatty liver disease (NAFLD) with and without CO.

Methods: One hundred seventy lean patients with NAFLD (BMI < 23 kg/m2) were divided into two groups depending upon the presence or absence of CO (waist circumference ≥80 cm in females and ≥90 cm in males). Noninvasive assessment of steatosis was done by ultrasound and controlled attenuation parameter (CAP), while fibrosis was assessed with FIB-4 and liver stiffness measurement (LSM). FibroScan-AST (FAST) score was used for non-invasive prediction of NASH with significant fibrosis.

Results: Of 170 patients with lean NAFLD, 96 (56.5%) had CO. Female gender (40.6% vs. 17.6%, P = 0.001), hypertriglyceridemia (58.3% vs. 39.2%, P = 0.01) and metabolic syndrome (23.9% vs. 4.1%, P < 0.001) were more common in the CO group. There was a poor correlation between BMI and waist circumference (r = 0.24, 95% CI: 0.09-0.38). Grade 2-3 steatosis on ultrasound was significantly more common in CO patients (30% vs. 12.3%, P = 0.007). CAP …

From The Icu Bedside: Applying The Transnational Clinical Academic Doctorate Lens To A Clinically Embedded Phd Journey, Gideon U. Johnson

Research outputs 2022 to 2026

Aim: To critically reflect on a transnational, clinically embedded doctoral journey undertaken during and after the COVID-19 pandemic, and to draw conceptual and systemic lessons for doctoral education and clinical academic nursing pathways. Background: Reflective accounts of doctoral study exist, yet few examine practice-based PhDs conducted across different countries and health systems during a global crisis. This paper analyses one such pathway—enrolment at an Australian university with research embedded within the UK National Health Service—to explore resilience, identity formation, mentorship ecologies and organisational conditions that support or hinder clinical academic development. Method: Using analytic autoethnography and reflective case study logic, …

Professional Experience In Initial Teacher Education: Integrating Standards, Supervisors And Mentor Teachers, Madlen Griffiths, Mandie Shean

Research outputs 2022 to 2026

Professional experience is the training ground for preservice teachers, where they apply what they have learned at university, in the reality of the classroom setting. Our article investigates the contribution of university supervisors to preservice teacher learning, from the perspective of both groups. This qualitative study gathered data from interviews with 28 preservice teachers and supervisors. Findings highlighted the complexity of the task assigned to supervisors, and the distinctive role that they play in the preservice teachers’ learning. This study offers a model of supervision drawn from the voices of these two key stakeholders that is underpinned by theory and …

Pfedrag: A Personalized Federated Retrieval-Augmented Generation System With Depth-Adaptive Tiered Embedding Tuning, Hangyu He, Xin Yuan, Kai Wu, Ren Ping Liu, Wei Ni

Research outputs 2022 to 2026

Large Language Models (LLMs) can undergo hallucinations in specialized domains, and standard Retrieval-Augmented Generation (RAG) often falters due to general-purpose embeddings ill-suited for domain-specific terminology. Though domain-specific fine-tuning enhances retrieval, centralizing data introduces privacy risks. The use of federated learning (FL) can alleviate this to some extent, but faces challenges of data heterogeneity, poor personalization, and expensive training data generation. We propose pFedRAG, a novel Personalized Federated RAG framework, which enables efficient collaborative fine-tuning of embedding models to address these challenges. The key contribution is a new Depth-Adaptive Tiered Embedding (DATE) architecture, which comprises a Global Shared Layer, combined using …

Electronic Resources Updates - 2024 Q4, Brigitte Galauner, Gregg Harris

Electronic Resources Quarterly Updates

No abstract provided.

Tourette Syndrome Research Highlights From 2024 [Version 3; Peer Review: 2 Approved, 1 Approved With Reservations], Andreas Hartmann, Per Andrén, Cyril Atkinson-Clement, Virginie Czernecki, Cécile Delorme, Simon Morand-Beaulieu, Nanette Mol Debes, Kirsten Müller-Vahl, Peristera Paschou, Natalia Szejko, Apostolia Topaloudi, Kevin J Black

2020-Current year OA Pubs

We summarize research reports from 2024 relevant to Tourette syndrome, which the authors consider the most important or interesting. This working draft aims to submit this content for publication around the beginning of 2025 in the yearly Tourette Syndrome Research Highlights series on F1000Research. The authors welcome article suggestions and thoughtful feedback from readers, who can add a comment by clicking on the rectangular comment box icon to the left of the LOG IN link at the top of this page. For private comments, you can reach us by email ( [email protected] or [email protected]).

Tracking The Evolving Role Of Artificial Intelligence In Implementation Science: Protocol For A Living Scoping Review Of Applications, Evaluation Approaches And Outcomes [Version 2; Peer Review: 2 Approved], Guillaume Fontaine, Byron J Powell, Et Al.

2020-Current year OA Pubs

BACKGROUND: Artificial intelligence (AI) offers significant opportunities to improve the field of implementation science by supporting key activities such as evidence synthesis, contextual analysis, and decision-making to promote the adoption and sustainability of evidence-based practices. This living scoping review aims to: (1) map applications of AI in implementation research and practice; (2) identify evaluation approaches, reported outcomes, and potential risks; and (3) synthesize reported research gaps and opportunities for advancing the use of AI in implementation science.

METHODS: This scoping review will follow the Joanna Briggs Institute (JBI) methodology and the Cochrane guidance for living systematic reviews. A living scoping …

Resource Assessment Report No. 01: Mid-West Scallop Resource 2024 Assessment, Jason How, Arani Chandrapavan, Rachel Marks

Resource Assessment Reports

The Mid-West Scallop Resource (Resource) is only accessed by the Abrolhos Islands Mid-West Trawl Managed Fishery (AIMWTMF). The AIMWTMF is the second largest scallop fishery in Western Australia. Access is limited to the 10 licences granted to access the Resource, which are managed through a range of, gear controls, catch rates and seasonal closures. They access saucer scallops, Ylistrum balloti (formerly Amusium balloti) using otter trawls fished over predominantly sand. The fishery was certified by the Marine Stewardship Council in 2021, with the fishery entering re-certification in 2026.

In 2024, 95.7 t meat weight (478.5 t whole weight) of saucer …

Practical Application Of Artificial Intelligence For Ecological Image Analysis: Trialling Different Levels Of Taxonomic Classification To Promote Convolutional Neural Network Performance, Amelia E.H. Bridges, Eleanor Cross, Kyran P. Graves, Nils Piechaud, Antony Raymont, Kerry L. Howell

School of Biological and Marine Sciences

The integration of artificial intelligence (AI), particularly convolutional neural networks (CNNs), into ecological research presents new opportunities for the automated analysis of image-based data. This study explores the practical application of CNNs for ecological image analysis by trialling annotation to different levels of taxonomic classification to determine their impact on model performance. We systematically compare various annotation strategies, evaluating their effects on the accuracy of CNNs in ecological contexts; as well as considering the feasibility of manually annotating training data to different levels. We demonstrate that variation in annotations groupings (animal, phylum or morphology) has little impact on model performance, …

Restoration Of River Connectivity Enables Long-Distance Spawning Migrations In A Potamodromous Fish, Dagmara Błońska, Ali Serhan Tarkan, Demetra Andreou, Jonathan D. Bolland, Peter Davies, Jamie R. Dodd, Phillipa Gillingham, Catherine Gutmann Roberts, Fatima Amat-Trigo, Sadi Aksu, Andrew Hindes, O. Jonas Palder, Mark Yeldham, J. Robert Britton

School of Biological and Marine Sciences

Rivers across the world are increasingly fragmented due to anthropogenic barriers, with the restoration of connectivity often using fish passes. Fish passes are, however, usually designed for anadromous species, despite ecologically important non-anadromous species being present in the communities impacted by fragmentation. To assess the outcomes for non-anadromous fishes of the installation of multiple fish passes and weir modifications, the movements of the potamodromous European barbel Barbus barbus were evaluated in the lower River Severn basin, western Britain, which was fragmented by six weirs (two on a tributary, four on the Severn mainstem). Movements of individual fish were measured using …

Large Marine Protected Areas Can Encompass Movements Of Diverse Megafauna, Alice M. Trevail, Ruth E. Dunn, Peter Carr, Nicole Esteban, Robin Freeman, Joanna L. Harris, Malcolm A.C. Nicoll, Nia Stephens, Guy M.W. Stevens, Stephen C. Votier, Hannah Wood, Graeme C. Hays

School of Biological and Marine Sciences

Global calls for greater ocean protection have sparked renewed interest in very large marine protected areas (VLMPAs, >100,000 km²) to achieve management targets; however, their conservation value is debated. We assessed the suitability of a VLMPA (640,000 km²) in the Indian Ocean for capturing the movements of resident mobile marine megafauna. We found that 95% of foraging, breeding and/or locally migrating individuals occurred within the VLMPA despite variable habitat use; adult hawksbill turtles (Eretmochelys imbricata, n = 22, 6124 tracking days) foraged on mesophotic banks (>30 m depth), reef manta rays (Mobula alfredi, n = …