Digital Commons Network^™

Exploring Implementation Strategies In Evidence-Based Open Streets Programs For Promoting Physical Activity In The Americas: A Scoping Review, Raúl D Gierbolini-Rivera, Milena Franco Silva, Lorna Fabiola Pineda, Bryan J Weiner, Byron J Powell, Ross C Brownson, Diana C Parra

2020-Current year OA Pubs

INTRODUCTION: Chronic diseases are a leading public health concern in the Americas, and physical inactivity contributes significantly to their burden. Open streets program-community initiatives that temporarily close urban streets to vehicles-promote physical activity and community engagement, demonstrating positive health and social impacts. Effective implementation depends on identifying suitable strategies and frameworks. The Expert Recommendations for Implementing Change (ERIC) taxonomy, developed for clinical/healthcare contexts, has not been widely assessed for community-based interventions such as Open Streets. Implementation strategies could lead to specific outcomes (e.g., adoption, sustainability) that differ from program outcomes (e.g., PA levels, chronic disease prevalence). This scoping review focuses …

Expanding The Spectrum Of White Matter Abnormalities In Wolfram Syndrome: A Retrospective Review, Justin Simo, Heather M Lugar, Tamara Hershey, Et Al.

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: Wolfram syndrome (WFS) is a genetic disorder mainly caused by pathogenic variants in the

METHODS: We conducted an international multicenter retrospective study of the clinical, genetic, and radiological data from 17 unrelated WFS subjects.

RESULTS: Seven subjects (7/17; 41%) showed at least one focal white matter lesion evocative of MS. Among these seven, three fulfilled the McDonald radiological criteria of dissemination in space and time, suggesting an inflammatory demyelinating process. All subjects reviewed in the study had at least one of the classical WFS MRI features.

CONCLUSION: Our report expands the WFS spectrum of white matter involvement …

More Than A ‘Decorative Frill’: Meaningful Engagement With Feminism In International Law, Nienke Grossman, Jaya Ramji-Nogales

Articles

No abstract provided.

Exosomes And Encapsulated Exomirs In Breast Cancer: Theragnostic Applications And Clinical Implications, Muhammad Imran Sajid, Shafia Bukhari, Hamid Ilyas, Rubina Malik, Minahil Fatima, Rakesh Kumar Tiwari, Surya M. Nauli, Khawaja Husnain Haider

Pharmacy Faculty Books and Book Chapters

Exosomes, released by cells, are small vesicles that have emerged as critical theranostic tools in breast cancer due to their unique ability to transport diverse biomolecules such as proteins, lipids, and RNAs, including microRNAs (ExomiRs). These vesicles are critical in modulating the tumor microenvironment, driving processes like cancer proliferation, invasion, metastasis, and drug resistance. Exosomal microRNAs such as ExomiR-21, ExomiR-1246, and ExomiR-155, with their profound influence on the gene expressions in the recipient cells, are the unsung heroes in tumor progression and immune modulation. This chapter delves into exosome's dual diagnostic and therapeutic potential in breast cancer. It highlights their …

Religious Liberty, Public Accommodations, And Non-Discrimination: A Rapidly Emerging Injustice, Gordon Babst

Political Science Faculty Books and Book Chapters

The decision in Burwell v. Hobby Lobby Stores, Inc., suggested to many that the scope of religious liberty was in a principled, logical way expanded to include free expression rights of corporate entities. It is concerning that many champion the decision as a basis for expanding religious exemptions to non-discrimination law as regards public accommodations, especially since the same reasoning that is being used with respect to the contemporary target of discrimination based in religious belief—American citizens who happen to be in a sexual minority—would apply by analogy, as it once did explicitly, to racial minorities. Unfortunately, given the …

Introduction To Contemporary Facets Of Injustice, Gordon Babst

Political Science Faculty Books and Book Chapters

Injustice itself is too infrequently the subject of direct rumination, with one notable exception being Judith Shklar’s The Faces of Injustice. The chapters in this volume consider some contemporary injustices, revealing their presence in ways that help to explain current issues that range from inequities in food access to the dangers of Christian nationalism, from better understanding how to conceptualize international law, to income disparity and the tax code.