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Articles 30211 - 30240 of 30289
Full-Text Articles in Entire DC Network
The Development Of The Trinitarian Charism In Poland And Its Realization, Maciej Kowalski
The Development Of The Trinitarian Charism In Poland And Its Realization, Maciej Kowalski
Occasional Papers on Religion in Eastern Europe
The aim of this article is to present the stages of development of the Trinitarian charism in Poland and to discuss the ways of its implementation, as well as to answer the question to what extent the Polish Trinitarians in their more than three hundred years of history have adapted the religious charism to their native conditions in changing historical circumstances. This, in turn, will allow better understanding of the heritage and activities of the Trinitarian Order in Poland, as well as to bring closer its multifaceted impact on various areas of Church and social life. The issues raised here, …
Frontmatter (Volume 45, Issue 8), Paul B. Mojzes
Frontmatter (Volume 45, Issue 8), Paul B. Mojzes
Occasional Papers on Religion in Eastern Europe
No abstract provided.
Hungarian Ruling Political Party Fidesz’S ‘Soft Power’ Use Of Religion: Themes, Networks, Partnerships, Alexander Faludy
Hungarian Ruling Political Party Fidesz’S ‘Soft Power’ Use Of Religion: Themes, Networks, Partnerships, Alexander Faludy
Occasional Papers on Religion in Eastern Europe
This article aims to stimulate better understanding of Fidesz’s use of religion as a ‘soft power’ tool. Exploring the Hungarian government’s ‘soft power’ has lately engaged the attention of professional researchers. The use of religious messaging, networks, and opinion formers to propagate positive images of Fidesz abroad has, however, largely been overlooked. This essay argues that such use has been both substantial and successful. The article’s primary focus will be on the use made of Christianity in government aligned communications and network building. Attention will, however, also be paid to the subsidiary roles played by Fidesz’s outreach to both Jewish …
The Social Policy Of Churches In Ukraine Today: Theoretical Foundations And Practical Implementation, Oleksandr Sagan, Mechyslav Yanauer
The Social Policy Of Churches In Ukraine Today: Theoretical Foundations And Practical Implementation, Oleksandr Sagan, Mechyslav Yanauer
Occasional Papers on Religion in Eastern Europe
This article examines the engagement of Ukrainian churches in addressing social challenges, emphasizing historical continuity and contemporary responses, particularly in the context of the ongoing Russian-Ukrainian war. The study highlights diverse social services provided by religious institutions, including chaplaincy, rehabilitation, advocacy, and humanitarian aid, noting significant contributions during pivotal moments such as the Orange Revolution, the Revolution of Dignity, and the recent military conflict. Religious organizations notably support military personnel, displaced persons, and trauma victims, and actively participate in international advocacy through diplomatic channels. The article explores the current state of social doctrines, highlighting the ongoing development and adaptation process …
Improving The Psychosocial Work Environment To Prevent Sickness Absence And Turnover In Nurses: A Systematic Review, Laurent Corthésy-Blondin, Alessia Negrini, Samantha Vila Masse, Christine Genest
Improving The Psychosocial Work Environment To Prevent Sickness Absence And Turnover In Nurses: A Systematic Review, Laurent Corthésy-Blondin, Alessia Negrini, Samantha Vila Masse, Christine Genest
Revues de littérature, synthèses de connaissances
In nurses, the high rates of sickness absence (SA) and turnover generate staggering costs. Their prevalence could be reduced by acting on the work-related psychosocial factors (WRPFs) that can impact the mental health of nurses and lead to their absences and departures. However, there is a lack of consensus regarding the effectiveness of interventions that target WRPFs from a SA and turnover prevention perspective. This systematic review aims to identify interventions that target WRPFs to reduce SA and turnover in nurses, describe the methods used to evaluate their effectiveness, and report on their effectiveness at improving SA, turnover rates, and …
Stem Professors’ Motivation To Engage In A College Teaching Certificate, Justin Craig Alexander
Stem Professors’ Motivation To Engage In A College Teaching Certificate, Justin Craig Alexander
Theses and Dissertations
Despite an expanded focus on educating students in STEM disciplines, nearly half of U.S. college students who enroll in these degree programs fail to graduate (Hamm et al., 2020, p. 623). Critics sometimes blame pedagogically untrained faculty (e.g., Kahn, 2022). This Dissertation in Practice (DiP) focused on STEM university faculty's motivation for teaching and whether professors are motivated to enroll in pedagogy courses. Via the lens of self-determination theory (SDT), this DiP examined to what extent STEM faculty at a major research university in the upper Midwest could devote additional time to pedagogy by enrolling in a college teaching graduate …
Strengthening The Health And Well-Being Of American Indian And Alaska Native Elders, Andria Begay
Strengthening The Health And Well-Being Of American Indian And Alaska Native Elders, Andria Begay
Theses and Dissertations
Health is a holistic concept within Indigenous communities, emphasizing the balance and interconnectedness of mind, body, and spirit. This dissertation explores the health and wellbeing of American Indian and Alaska Native Elders, with each of the products for this three-part portfolio, targeting different health matters that are often overlooked among Elders, aged 55 years and older. Using secondary data from National Resource Center on Native American Aging’s 2020-2023 cycle of the Identifying our Needs: A Survey of Elders, I conducted three quantitative research analyses with chi-square tests and binary logistic regressions to assess the association and differences in variables. Manuscript …
The Effects Of Chronic Sleep Deprivation On Visuomotor Performance Using Electroencephalographic Measurement, Jaxon Duane Erie
The Effects Of Chronic Sleep Deprivation On Visuomotor Performance Using Electroencephalographic Measurement, Jaxon Duane Erie
Theses and Dissertations
The present study investigated the impact of acute and chronic sleep deprivation on visuomotor performance using both electroencephalographic (EEG) and behavioral measures (Senaptec Sensory Station) in a sample of 43 college students aged 18 to 27. Participants were assigned to low or high sleep conditions based on Chronic Sleep Reduction Questionnaire (CSRQ) scores, while acute sleep deprivation was assessed via the Karolinska Sleepiness Scale (KSS). Heart rate variability (HRV) was recorded to support condition placement, but comparisons revealed no significant differences between groups. No significant differences were found in visuomotor control or eye-quickness assessments. However, visual clarity was significantly better …
Perceptions Of Emotional Abuse As A Partial Function Of The Abuser-Victim Gender Dyad, Kaitlyn Kidder
Perceptions Of Emotional Abuse As A Partial Function Of The Abuser-Victim Gender Dyad, Kaitlyn Kidder
Theses and Dissertations
Emotional abuse affects approximately half of people in an intimate relationship, yet it is often not considered intimate partner violence (IPV) on its own (Dokkedahl et al., 2022; Leemis et al., 2022). Despite the prevalence, there is a lack of consistency on the definition of emotional abuse and IPV as well as a lack of clarity of what acts qualify for these terms. Past research has largely focused on IPV, specifically physical or sexual abuse, in heterosexual relationships with a male perpetrator and female victim. Few studies have explored the interactions of the gender of the victim and perpetrator in …
Exploring Student-Athlete Perceptions On Nil Opportunities In The Cannabinoid Industry, Katherine Klimchock
Exploring Student-Athlete Perceptions On Nil Opportunities In The Cannabinoid Industry, Katherine Klimchock
Theses and Dissertations
The introduction of Name, Image, and Likeness (NIL) regulations in collegiate athletics has created new financial and branding opportunities for student-athletes. Simultaneously, there has been an evolving legal landscape surrounding cannabinoids both at the state and National Collegiate Athletic Association (NCAA) levels. This dissertation in practice explores this emerging intersection by examining student-athlete perceptions of NIL opportunities with cannabinoid brands and highlighting the perceived advantages and disadvantages of such deals. This dissertation in practice consists of three artifacts. Artifact I provides essential background information on NIL, cannabinoids, and the House v. NCAA settlement. Recognizing the legal, institutional, and cultural shifts …
Strengthening Traffic Safety Laws On The Crow Indian Reservation, Darcy Merchant
Strengthening Traffic Safety Laws On The Crow Indian Reservation, Darcy Merchant
Theses and Dissertations
The Crow Indian reservation is located in south-central Montana. The reservation is one of the largest land-based tribes in Montana, encompassing an area of over three thousand square miles. The reservation borders the state of Wyoming to the south and the Northern Cheyenne Indian reservation to the east. The reservation features a comprehensive transportation system that encompasses tribal, county, state, and federal roadways. Drivers and passengers who travel on these roadways are at higher risk for fatal and severe injury-related motor vehicle crashes than those in other reservations. This situation largely stems from the critical absence of targeted traffic safety …
Chemical Looping As An Enabling Technology For Low-Carbon Energy Production, Junior Neguieh Domkam Nasah
Chemical Looping As An Enabling Technology For Low-Carbon Energy Production, Junior Neguieh Domkam Nasah
Theses and Dissertations
Growth in global gross domestic product has historically been tied with high-carbon energy sources. Development of new low-carbon energy technologies is thus key to achieving a de-coupling of energy demand from economic growth. This dissertation evaluates the technical feasibility of a small-scale low-carbon solution referred to as Combined Hydrogen, Heat and Power (CH2P), a synthesis gas to hydrogen chemical looping process. The CH2P process is based on the steam-iron process and adopts multiple batch reactors to convert syngas in a two-step approach. First, the syngas is partially oxidized by reducing Magnetite (Fe3O4) to Wüstite (FeO) followed by complete oxidation in …
The Roles Of Readily Releasable Stores Of Endolysosome Iron In The Pathogenesis And Treatment Of Alzheimer's Disease, Darius N.K Quansah
The Roles Of Readily Releasable Stores Of Endolysosome Iron In The Pathogenesis And Treatment Of Alzheimer's Disease, Darius N.K Quansah
Theses and Dissertations
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized clinically as progressive decline in cognition and dementia. Pathologically, AD is characterized by the extracellular presence of senile plaques composed of accumulated amyloid beta (Aβ) proteins and intraneuronal accumulation of neurofibrillary tangles composed of hyperphosphorylated tau proteins. In addition to these pathological hallmarks, AD pathogenesis is characterized by increases in intracellular iron and reactive oxygen species (ROS) and the link between the two have been well described by Fenton’s chemistry. Endolysosomes appear to be affected very early in the onset of AD. Endolysosomes contain labile stores of iron which can be readily …
Public Perceptions Of Fracking And Anti-Fracking Activism: A Theory Of Planned Behavior Approach And Its Implications For Environmental Policy, Okhumode Hector Yakubu
Public Perceptions Of Fracking And Anti-Fracking Activism: A Theory Of Planned Behavior Approach And Its Implications For Environmental Policy, Okhumode Hector Yakubu
Theses and Dissertations
Hydraulic fracturing, or fracking, has become one of the most contentious energy technologies of the 21st century, drawing support for its economic and energy security benefits and opposition due to its perceived environmental and health risks. This study applies the Theory of Planned Behavior (TPB) to examine the psychological, social, and informational factors that shape public perceptions of fracking and motivate anti-fracking activism. Using a nationally representative sample of U.S. adults (N = 522), this research investigates how attitudes, subjective norms, perceived behavioral control, and domain-specific knowledge predict support or opposition to fracking, as well as intentions to engage in …
Shedding Light To The Rights To Light In England And Wales: The Need For Reform, Goodtime Okara
Shedding Light To The Rights To Light In England And Wales: The Need For Reform, Goodtime Okara
School of Law, Humanities and Social Sciences
The right to light is unarguably a right that could hinder the development of the servient land. Owing to the possibility of granting a mandatory injunction when breached, this right could lead to extra costs and delays in the efficient development of the servient land by real property developers, even when the dominant tenement does not wish to enjoy the right. Hence, this paper critically reflects on rights to light in England and Wales to determine the impact of this right on the servient land. It explores the direction of travel across the Courts – by briefly examining rights to …
Fixing Fixed Term Recall An Insights Paper: February 2025, Miranda Shanks, Katie Mcbride, Zoë James
Fixing Fixed Term Recall An Insights Paper: February 2025, Miranda Shanks, Katie Mcbride, Zoë James
School of Law, Humanities and Social Sciences
This Insights Paper seeks to provide a comprehensive understanding of the application of fixed term recall (FTR) within the criminal justice system (CJS) and their impact on the rehabilitation and resettlement journeys of individuals on licence. The paper explores how FTR are currently being applied, examines the experiences of those subject to them, and identifies strategies to reduce the use of FTR while improving their effectiveness in managing non-compliance of low-risk individuals.
Exploring Islamophobia Through Intersectionality., Suparna Bagchi
Exploring Islamophobia Through Intersectionality., Suparna Bagchi
School of Law, Humanities and Social Sciences
No abstract provided.
The Moral Regime Of Midwifery Continuity Of Carer Implementation In England, Aimee Louise Middlemiss, Susan Channon, Julia Sanders, Heather Strange, Rebecca Milton, Sara Kenyon, Tina Prendeville, Susan Barry, Aled Jones
The Moral Regime Of Midwifery Continuity Of Carer Implementation In England, Aimee Louise Middlemiss, Susan Channon, Julia Sanders, Heather Strange, Rebecca Milton, Sara Kenyon, Tina Prendeville, Susan Barry, Aled Jones
School of Nursing and Midwifery
Since 2016, the National Health Service (NHS) in England has been aiming to implement midwifery continuity of carer (MCoC), a model of maternity care in which the same midwife or small group of midwives provides antenatal, intrapartum and postnatal care for women, other birthing people and their babies. However, the implementation has faced significant difficulties. As part of a wider investigation into barriers to and facilitators of MCoC implementation, we carried out qualitative interviews with senior stakeholders involved in the implementation of MCoC at regional or national level in England. In this paper, we present an analysis of sociocultural values …
The Use Of Tele-Music Interventions In Supportive Cancer Care: A Systematic Review, Lore Mertens, Laura Tack, Tom Boterberg, Jörg Fachner, Leonardo Muller-Rodriguez, Marte Vandeweyer, Sofie Demasure, Marianne Hanssens, Tine Loyson, Laurence Goethals, Isabelle Kindts, Hannelore Denys, Patricia Schofield, Mohammad Najlah, Philip R. Debruyne
The Use Of Tele-Music Interventions In Supportive Cancer Care: A Systematic Review, Lore Mertens, Laura Tack, Tom Boterberg, Jörg Fachner, Leonardo Muller-Rodriguez, Marte Vandeweyer, Sofie Demasure, Marianne Hanssens, Tine Loyson, Laurence Goethals, Isabelle Kindts, Hannelore Denys, Patricia Schofield, Mohammad Najlah, Philip R. Debruyne
School of Nursing and Midwifery
Objectives: This systematic review seeks to provide an in-depth overview of current research on tele-music interventions in supportive cancer care and identifies key areas where further research is warranted. Methods: A comprehensive search was conducted across four electronic databases (Scopus, Embase, Web of Science, and PubMed) without any data restrictions and according to the PRISMA guidelines. The primary outcome measure was the effect of tele-music interventions on psychosocial functioning. Results: Of the 2.043 articles initially identified, nine studies met the inclusion criteria and were selected for qualitative analysis. Among the music interventions, considerable variation was observed regarding delivery format and …
Discussing Poverty Within Primary Care Consultations: Implications For Mental Health Support, F. Thomas, K. Wyatt, K. Berzins, I. Lee, J. Horrell, A. Mcloughlin
Discussing Poverty Within Primary Care Consultations: Implications For Mental Health Support, F. Thomas, K. Wyatt, K. Berzins, I. Lee, J. Horrell, A. Mcloughlin
Peninsula Medical School
No abstract provided.
Next-Gen Device For Uniform Cellular Migration Assay Execution, Nicholas M. Bittner
Next-Gen Device For Uniform Cellular Migration Assay Execution, Nicholas M. Bittner
Theses and Dissertations
Cellular migration assays, particularly scratch assays, are pivotal in biomedical research for cell motility, wound healing, and metastasis. However, conventional scratch assays suffer from variability due to operator dependence, non-uniform scratch geometry, and a modified microenvironment that impacts reproducibility. This thesis presents the development and validation of a low-cost, 3D-printed device designed to standardize cellular migration assays. The device utilizes a spring mechanism and a biocompatible elastomer to create a uniform cellular exclusion zone without harming the surrounding cells. Through iterative prototyping and testing with MCF10A cell lines, the device demonstrated a significantly lower average standard deviation of length compared …
Thermally Induced Evolution Of The Cement Microannulus In Co2 Injection Wells, Jawad Ali Khan
Thermally Induced Evolution Of The Cement Microannulus In Co2 Injection Wells, Jawad Ali Khan
Theses and Dissertations
Ensuring wellbore integrity during CO2 injection is a critical challenge in Carbon Capture and Storage (CCS), as failures at the casing-cement and cement-formation interfaces can create potential leakage pathways. This dissertation presents a multi-scale, physics-based investigation into well integrity risks, integrating finite element analysis (FEA), thermal-mechanical-poroelastic modeling, and transient stress analysis to evaluate cement sheath stability, fracture-driven stress localization, and microannulus formation under various CCS conditions.
A key novelty of this research is the development of a fully coupled thermal-mechanical-poroelastic FEA framework using COMSOL Multiphysics, a renowned industry-standard software for multiphysics simulations. This model enables a dynamic, time-dependent assessment …
Computational Argumentation And Automatic Rule-Generation For Explainable Data-Driven Modeling, Luca Longo, Serena Berretta, Damiano Verda, Lucas Rizzo
Computational Argumentation And Automatic Rule-Generation For Explainable Data-Driven Modeling, Luca Longo, Serena Berretta, Damiano Verda, Lucas Rizzo
Research Outputs: 2025-Present
The creation of data-driven models for classification problems requires increasing transparency and inferential explainability, especially in high-stakes domains such as health-care, finance, and policy making. Rule-based systems are widely regarded as a strong candidate for the development of models that are also comprehensible to humans. However, the generated rules are often considered individually with minimal or no consideration of their interactions. This research focuses on the adoption of computational argumentation techniques, which allow for rule-interaction for enhanced explainability. In other words, rules can be revoked when new information is introduced, essentially achieving the notion of non-monotonicity. In detail, an empirical …
Accreditation Considerations In Engineering Ethics Education: Bridging Global Standards And Local Practices: Bridging Global Standards And Local Practices, Louise O'Gorman, Alison Gwynne-Evan, Leah Ridgeway, Marek Rebow, Shannon Chance
Accreditation Considerations In Engineering Ethics Education: Bridging Global Standards And Local Practices: Bridging Global Standards And Local Practices, Louise O'Gorman, Alison Gwynne-Evan, Leah Ridgeway, Marek Rebow, Shannon Chance
Research Outputs: 2025-Present
Accreditation can drive curricular innovation and change in engineering and can have a role in encouraging students' development of ethics-related competencies. Despite engineering educators' competence in the technical aspects of design and research, there can be an element of discomfort in planning and delivering lessons relating to ethics that span social justice, diversity and inclusion, environmental sustainability, and ethical theories. Because engineering accreditation can encourage and/or require the inclusion of ethical content in accredited engineering courses, the recently published Routledge Handbook of Engineering Ethics Education dedicated an entire section to the topic. This paper critically assesses the handbook's accreditation section …
An Empirical Evaluation Of Communication Technologies And Quality Of Delivery Measurement In Networked Microgrids, Yasin Emir Kutlu, Ruairí De Fréin
An Empirical Evaluation Of Communication Technologies And Quality Of Delivery Measurement In Networked Microgrids, Yasin Emir Kutlu, Ruairí De Fréin
Research Outputs: 2025-Present
Networked microgrids (NMG) are gaining popularity as an example of smart grids (SG), where power networks are integrated with communication technologies. Communication technologies enable NMGs to be monitored and controlled via communication networks. However, ensuring that communication networks in NMGs satisfy quality of delivery (QoD) metrics such as the round trip time (RTT) of NMG control data is necessary. This paper addresses the communication network types and communication technologies used in NMGs. We present various NMG deployments to demonstrate real-life applicability in different contexts. We develop a real-time NMG testbed using real hardware, such as Cisco 4331 Integrated Services Routers …
Optimal Timing Of Organs-At-Risk-Sparing Adaptive Radiation Therapy For Head-And-Neck Cancer Under Re-Planning Resource Constraints, Fatemeh Nosrat, Cem Dede, Lucas B Mccullum, Raul Garcia, Abdallah S R Mohamed, Jacob G Scott, James E Bates, Brigid A Mcdonald, Kareem A Wahid, Mohamed A Naser, Renjie He, Aysenur Karagoz, Amy C Moreno, Lisanne V Van Dijk, Kristy K Brock, Jolien Heukelom, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Andrew J Schaefer, Clifton D Fuller
Optimal Timing Of Organs-At-Risk-Sparing Adaptive Radiation Therapy For Head-And-Neck Cancer Under Re-Planning Resource Constraints, Fatemeh Nosrat, Cem Dede, Lucas B Mccullum, Raul Garcia, Abdallah S R Mohamed, Jacob G Scott, James E Bates, Brigid A Mcdonald, Kareem A Wahid, Mohamed A Naser, Renjie He, Aysenur Karagoz, Amy C Moreno, Lisanne V Van Dijk, Kristy K Brock, Jolien Heukelom, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Andrew J Schaefer, Clifton D Fuller
Faculty, Staff and Student Publications
Background and purpose: Prior work on adaptive organ-at-risk (OAR)-sparing radiation therapy has typically reported outcomes based on fixed-number or fixed-interval re-planning, which represent one-size-fits-all approaches and do not account for the variable progression of individual patients' toxicities. The purpose of this study was to determine the personalized optimal timing of re-planning in adaptive OAR-sparing radiation therapy, considering limited re-planning resources, for patients with head and neck cancer (HNC).
Materials and methods: A novel Markov decision process (MDP) model was developed to determine optimal timing of re-planning based on the patient's expected toxicity, characterized by normal tissue complication probability (NTCP), for …
The Influence Of The Microbiome On Radiotherapy And Dna Damage Responses, Aadil Sheikh, Michael A Curran
The Influence Of The Microbiome On Radiotherapy And Dna Damage Responses, Aadil Sheikh, Michael A Curran
Faculty, Staff and Student Publications
Colorectal cancer (CRC) is one of the most prevalent cancers in terms of diagnosis and mortality. Radiotherapy (RT) remains a mainstay of CRC therapy. As RT relies on DNA damage to promote tumor cell death, the activity of cellular DNA damage repair pathways can modulate cancer sensitivity to therapy. The gut microbiome has been shown to influence intestinal health and is independently associated with CRC development, treatment responses and outcomes. The microbiome can also modulate responses to CRC RT through various mechanisms such as community structure, toxins and metabolites. In this review we explore the use of RT in the …
Acute Myeloid Leukemia Management And Research In 2025, Hagop M Kantarjian, Courtney D Dinardo, Tapan M Kadia, Naval G Daver, Jessica K Altman, Eytan M Stein, Elias Jabbour, Charles A Schiffer, Amy Lang, Farhad Ravandi
Acute Myeloid Leukemia Management And Research In 2025, Hagop M Kantarjian, Courtney D Dinardo, Tapan M Kadia, Naval G Daver, Jessica K Altman, Eytan M Stein, Elias Jabbour, Charles A Schiffer, Amy Lang, Farhad Ravandi
Faculty, Staff and Student Publications
The first 5 decades of research in acute myeloid leukemia (AML) were dominated by the cytarabine plus anthracyclines backbone, with advances in strategies including allogeneic hematopoietic stem cell transplantation, high-dose cytarabine, supportive care measures, and targeted therapies for the subset of patients with acute promyelocytic leukemia. Since 2017, a turning point in AML research, 12 agents have received regulatory approval for AML in the United States: venetoclax (BCL2 inhibitor); gemtuzumab ozogamicin (CD33 antibody-drug conjugate); midostaurin, gilteritinib, and quizartinib (fms-like tyrosine kinase 3 inhibitors); ivosidenib, olutasidenib, and enasidenib (isocitrate dehydrogenase 1 and 2 inhibitors); oral azacitidine (a partially absorbable formulation); CPX351 …
High-Grade B-Cell Lymphoma Not Otherwise Specified, With Diffuse Large B-Cell Lymphoma Gene Expression Signatures: Genomic Analysis And Potential Therapeutics, Waseem Lone, Alyssa Bouska, Tyler A Herek, Catalina Amador, Joo Song, Alexander M Xu, Dylan Jochum, Issa Ismail Issa, Dennis D Weisenburger, Xuan Zhang, Sharath Kumar Bhagavathi, Tayla B Heavican-Foral, Sunandini Sharma, Ab Rauf Shah, Abdul Rouf Mir, Aisha Ahmad Alkhinji, Dalia El-Gamal, Bhavana J Dave, Keenan Hartert, Jiayu Yu, Mallick Saumyaranjan, Timothy C Greiner, Julie Vose, Timothy W Mckeithan, Kai Fu, Michael Green, Chengfeng Bi, Akil Merchant, Wing C Chan, Javeed Iqbal
High-Grade B-Cell Lymphoma Not Otherwise Specified, With Diffuse Large B-Cell Lymphoma Gene Expression Signatures: Genomic Analysis And Potential Therapeutics, Waseem Lone, Alyssa Bouska, Tyler A Herek, Catalina Amador, Joo Song, Alexander M Xu, Dylan Jochum, Issa Ismail Issa, Dennis D Weisenburger, Xuan Zhang, Sharath Kumar Bhagavathi, Tayla B Heavican-Foral, Sunandini Sharma, Ab Rauf Shah, Abdul Rouf Mir, Aisha Ahmad Alkhinji, Dalia El-Gamal, Bhavana J Dave, Keenan Hartert, Jiayu Yu, Mallick Saumyaranjan, Timothy C Greiner, Julie Vose, Timothy W Mckeithan, Kai Fu, Michael Green, Chengfeng Bi, Akil Merchant, Wing C Chan, Javeed Iqbal
Faculty, Staff and Student Publications
High-grade B-cell lymphoma not otherwise specified (HGBCL, NOS) has overlapping morphological and genetic features with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL), leading to uncertainty in its diagnosis and clinical management. Using functional genomic approaches, we previously characterized HGBCL and NOS, that demonstrate gene expression profiling (GEP), and genetic signatures similar to BL. Herein, we characterize distinct HGBCL, NOS, cohort (n = 55) in adults (n = 45) and in children (n = 10), and compared the GEP, genomic DNA copy number (CN), and mutational spectrum with de novo DLBCL (n = 85) and BL (n = 52). …
Il-7: A Potential Next-Generation Adjuvant For Immune Cell Therapies, Richard S Hotchkiss, John F Dipersio, Cassian Yee, Russell K Pachynski, Marcel R M Van Den Brink
Il-7: A Potential Next-Generation Adjuvant For Immune Cell Therapies, Richard S Hotchkiss, John F Dipersio, Cassian Yee, Russell K Pachynski, Marcel R M Van Den Brink
Faculty, Staff and Student Publications
Cell-based immune therapies ranging from CAR-T cells to tumor infiltrating lymphocytes (TILs) and endogenous T-cell products, have produced unprecedented clinical responses in hematologic malignancies and are currently under active investigation for solid tumors. Nevertheless, several key challenges continue to limit the durability and breadth of clinical benefit. IL-7 is a pleiotropic cytokine that increases both the number and function of lymphocytes. Although not yet clinically approved, IL-7 has been used in over 620 adult and pediatric patients for a variety of reasons including, for example, to hasten bone marrow recovery after allogenic stem cell transplantation, to reverse lymphopenia due to …