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Articles 9661 - 9690 of 31573
Full-Text Articles in Entire DC Network
The Perennial Scope Of Philosophy, Karl Jaspers
The Perennial Scope Of Philosophy, Karl Jaspers
Hannah Arendt Marginalia - All
New York, Philosophical Library [c1949]
Call #: B3279.J33 P33
Contains marginalia, underlining, marginal lining and is inscribed by J.M. Cuddihy
PDF Information: 40 pages – 29.6 MB
Bayes In The Brain: A Review Of Everything Is Predictable: How Bayesian Statistics Explain Our World, (2024) By Tom Chivers., Michael T. Catalano
Bayes In The Brain: A Review Of Everything Is Predictable: How Bayesian Statistics Explain Our World, (2024) By Tom Chivers., Michael T. Catalano
Numeracy
Tom Chivers’ Everything is Predictable: How Bayesian Statistics Explain Our World, is an interesting and wide-ranging narrative on Bayesian thinking, its history, and its applicability to both our everyday lives and the pursuit of scientific truth. Although appropriate for the non-expert, afficionados and teachers of quantitative literacy should find the plethora of examples, links to psychology as it applies to how people reason about probabilities, and even Chivers’ philosophical musings informative and thought-provoking.
Paideia: The Ideals Of Greek Culture V.2, Werner Jaeger
Paideia: The Ideals Of Greek Culture V.2, Werner Jaeger
Hannah Arendt Marginalia - All
New York: Oxford university press, 1939-
Contains marginalia, underlining, marginal lining endpaper notes.
Call #: DF77 .J27
PDF Information: 92 pages – 91.9mb
Echo Burn, Noah Bussey
Sein Und Zeit, Martin Heidegger
Sein Und Zeit, Martin Heidegger
Hannah Arendt Marginalia - All
Tübingen: Neomarius, 1949
Call #: B3279.H48 S4 1949
Contains marginalia, underlining, marginal lining and endpaper notes.
PDF Information: 243 pages – 133 mb
Philosophic Problems Of Nuclear Science, Werner Heisenberg
Philosophic Problems Of Nuclear Science, Werner Heisenberg
Hannah Arendt Marginalia - All
New York Pantheon [©1952]
Arendt copy contains marginal lining
PDF Information: 27 pages – 2.1 MB
Physics And Philosophy: The Revolution In Modern Science, Werner Heisenberg
Physics And Philosophy: The Revolution In Modern Science, Werner Heisenberg
Hannah Arendt Marginalia - All
New York : Harper & Row 1962.
Call#: QC6 .H34 1962
Contains marginal lining
PDF information: 12 pages – 16.5 MB
Safety Handbook - Faculty And Staff
Safety Handbook - Faculty And Staff
University press releases and calendars
No abstract provided.
Icipe Spotlight Magazine 2025, International Centre Of Insect Physiology And Ecology (Icipe)
Icipe Spotlight Magazine 2025, International Centre Of Insect Physiology And Ecology (Icipe)
icipe Newsletters
Join us through a journey of a tapestry of voices, landscapes and possibilities. Get a copy of our inaugural edition of the icipe Spotlight magazine, a publication that is especially close to our hearts. The magazine illuminates our scientific breakthroughs and the lives they touch. While we celebrate our contribution to the global knowledge hub, our deepest fulfillment is in witnessing how the Centre’s knowledge and innovations transform lives and foster resilience.
Is “Pre-Sepsis” The New Sepsis? A Narrative Review, Rémy Gerard, Antoine Dewitte, Fridolin Gross, Thomas Pradeu, Maël Lemoine, Julien Goret, Maria Mamani-Matsuda
Is “Pre-Sepsis” The New Sepsis? A Narrative Review, Rémy Gerard, Antoine Dewitte, Fridolin Gross, Thomas Pradeu, Maël Lemoine, Julien Goret, Maria Mamani-Matsuda
Presidential Fellows Articles and Research
Sepsis is a life-threatening condition caused by a dysregulated immune response to infection, leading to organ dysfunction and high mortality. Despite advances in treatment, sepsis remains difficult to manage. Historically, the concept of sepsis evolved from ancient observations of infection-related decay to the germ theory of the 19th century. The latest Sepsis-3 definition describes sepsis as life-threatening organ dysfunction due to a dysregulated host response. However, this clinical characterization may be too late for effective intervention. The concept of endotypes and the ontological data applied to sepsis highlight the substantial heterogeneity in pathophysiological pathways leading to this endpoint. We propose …
Effect Of Moringa Oil And Flaxseed Oil On Lipid Profile Of Male Rats Exposed To Carbendazim, Muhammad Hashim, Isam M. Abu Zeid, Atef M. Al-Attar
Effect Of Moringa Oil And Flaxseed Oil On Lipid Profile Of Male Rats Exposed To Carbendazim, Muhammad Hashim, Isam M. Abu Zeid, Atef M. Al-Attar
The Journal of King Abdulaziz University: Science
Carbendazim (CBZ), a commonly used fungicide, has been linked to adverse effects on the lipid profile. This study investigated whether Moringa and Flaxseed oils could mitigate CBZ-induced toxicity in male rats. Sixty male rats were divided into six groups: control, CBZ (200 mg/kg) treated, CBZ + Moringa Oil, CBZ + Flaxseed Oil, Moringa treated, and Flaxseed Oil treated. The oils were administered at 800 mg/kg for six weeks. Lipid parameters, including total cholesterol (TC), triacylglycerols (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and high-density lipoprotein (HDL), were analyzed. CBZ elevated TC, TG, LDL, and VLDL levels, while reducing HDL. Moringa …
Exploring Tricine As A Novel Red Cell Cryopreservative: Lessons And Future Directions, Thomas Bailey-Schmidt, Christine V Saunders, Chloë E George, Thomas G Scorer, Lynn M R Mccallum, Tracey E Madgett
Exploring Tricine As A Novel Red Cell Cryopreservative: Lessons And Future Directions, Thomas Bailey-Schmidt, Christine V Saunders, Chloë E George, Thomas G Scorer, Lynn M R Mccallum, Tracey E Madgett
School of Biomedical Sciences
BACKGROUND AND OBJECTIVES: Cryopreservation allows for storage of red blood cells (RBCs) beyond the standard 35-day period. Current glycerol-based methods are labour-intensive and scale-limited in application. Tricine has been identified as a potential alternative cryoprotectant (CPA), demonstrating efficacy in sheep RBC. This study aims to evaluate the biocompatibility and efficacy of tricine in human RBC cryopreservation.
MATERIALS AND METHODS: Human and sheep RBCs were exposed to varying concentrations of tricine (2.0-20.0% w/v) or glycerol (20.0-40.0% w/v). Biocompatibility was assessed via 24-h incubation at 4°C, while cryoprotective efficacy was evaluated following freezing in liquid nitrogen, storage at -80°C and thawing at …
Chalcone-Based Random Copolyesters Synthesis With Cytocompatibility Properties, Mohammad Mujahid, Mohd Imran Rais, Omar Abdullah Al-Hartomy, Ahmed Obaid Mosa Alzahrani
Chalcone-Based Random Copolyesters Synthesis With Cytocompatibility Properties, Mohammad Mujahid, Mohd Imran Rais, Omar Abdullah Al-Hartomy, Ahmed Obaid Mosa Alzahrani
The Journal of King Abdulaziz University: Science
Eight random copolyesters were compiled into a list. They were created by employing aromatic and aliphatic diacid chlorides in the polycondensation of chalcone diol. Terephthaloyl chloride was the aromatic diacid chloride that was employed, while adipoyl, oxalyl, glutaryl and succinyl chlorides were the other aliphatic diacid chlorides. The reaction of Claisen-Schmidt condensation in the acidic medium was applied for the synthesis of chalcone. Solubility in several solvents and measurements of viscosity were done for the initial characterization of synthesized copolyesters. The other techniques of characterization used were. To know about the units that are repeated in the polymer chain, spectral …
Assessing Effectiveness Of Runnel Restoration In New England Salt Marsh Habitats, David M. Burdick, Grant Mckown, Gregg Moore, Jenny Gibson, Wenley Ferguson, John Herbert, Nancy Pau, Susan Adamowicz, Geoff Wilson
Assessing Effectiveness Of Runnel Restoration In New England Salt Marsh Habitats, David M. Burdick, Grant Mckown, Gregg Moore, Jenny Gibson, Wenley Ferguson, John Herbert, Nancy Pau, Susan Adamowicz, Geoff Wilson
Faculty Publications
Rising sea levels that increase flooding in salt marshes recovering from hydrologic impairments is reducing nesting habitat for salt marsh sparrows. Abandonment of colonial farming practices (1600s through 1900s) has resulted in large, waterlogged basins characterized by shallow depressions (pannes) dominated by short-form Spartina alterniflora and unvegetated megapools that are subsiding. A relatively new technique designed to provide regular tidal flooding and drainage to the waterlogged basins that have formed on the marsh is runnelling – creation of shallow hydrologic features on the marsh surface. Will runnels result in revegetation of pannes and pools with productive perennial grasses that are …
Highly Contaminated Sediments From The Gowanus Canal (New York) Superfund Site: An Environmental Forensic Approach, Michael A. Kruge, Kevin K. Olsen, Eric A Stern, Maria Mastalerz, Albert Permanyer
Highly Contaminated Sediments From The Gowanus Canal (New York) Superfund Site: An Environmental Forensic Approach, Michael A. Kruge, Kevin K. Olsen, Eric A Stern, Maria Mastalerz, Albert Permanyer
Department of Earth and Environmental Studies Faculty Scholarship and Creative Works
The 2.5 km long Gowanus Canal (Brooklyn, NY, USA) is a severely contaminated urban waterway dating from the mid-19th century, listed as a US Environmental Protection Agency (USEPA) Superfund site since 2010. Applying an environmental forensics approach to the extensive USEPA data set, we detect systematic variations in parent PAH ring number distributions in the canal sediments, as well as an extraordinary enrichment in organic carbon. We subjected a supplemental sample set to a more detailed analysis by quantitative pyrolysis-GC-MS, Rock-Eval pyrolysis, and organic petrology. With these sensitive methods, we can confirm the alkyl-PAH fingerprint of coal tar (a legacy …
Animal Interiority: Sentience And Spatial Perception, Raymund Königk
Animal Interiority: Sentience And Spatial Perception, Raymund Königk
Interiority
Interior design has traditionally prioritised human experiences, often neglecting ecological and nonhuman perspectives on interiority. This anthropocentric focus limits the discipline's ability to address the spatial and sensory needs of nonhuman persons, including teleost fishes. It overlooks interiority as a universal and relational phenomenon shared by all living beings. This research challenges these boundaries by proposing a biosemiotic framework that integrates the body, interiority, and inhabitation as interdependent constructs shaped by physiological, mental, and environmental interactions. By developing Jakob von Uexküll's (1982) biosemiotic schema, the study investigates the sentient experiences of teleost fishes to establish interiority as a capability inherent …
Using Herpetofauna To Determine Wetland Health And Function In The Red River Watershed, Shelby Rodriguez-Edwards
Using Herpetofauna To Determine Wetland Health And Function In The Red River Watershed, Shelby Rodriguez-Edwards
Biology Theses
Reptiles and amphibians are commonly used indicator species in wetlands because of their increased sensitivity to environmental conditions and use of both aquatic and terrestrial habitats. Herpetofauna can reflect wetland ecological functionality through their community composition and responsiveness to environmental stressors. This study evaluated reptile and amphibian communities in natural and ACEP-WRE wetlands within the Red River Watershed of northeastern Texas and Northwestern Louisiana to assess whether restored wetlands support herpetofaunal assemblages compares to their natural counterparts. Fifteen wetlands were surveyed from February to June 2024 using visual encounter surveys, call surveys, and standardized trapping methods to document species richness …
Techno-Economic Analysis (Tea) And Life-Cycle Assessment (Lca) Of Sustainable Aviation Fuel (Saf) Production Through Circular Economy (Ce) Practices: A Focus On Supply Chain Optimization And Policy Implications, Edmund Gyandoh
Chemical and Biological Engineering ETDs
This study provides a comprehensive systems-level evaluation of an integrated circular biorefinery for sustainable aviation fuel (SAF) production. Employing supply chain optimization, technoeconomic analysis, lifecycle analysis, policy modeling, and multicriteria decision analysis, the research assesses technical feasibility, economic viability, and environmental performance. The circular economy model demonstrates exceptional resource efficiency, achieving a 92.3% overall circularity score with strong material recycling, water reuse, waste minimization, and near-complete energy recovery, resulting in net-negative carbon emissions and net energy export. Scaling the facility to commercial capacity (500 million liters per year) enables significant economic improvements. The minimum fuel selling price (MFSP) decreases from …
Characterizing Host And Viral Factors Relevant To Turkey Hemorrhagic Enteritis Virus-Induced Immunosuppression, Abraham Quaye
Characterizing Host And Viral Factors Relevant To Turkey Hemorrhagic Enteritis Virus-Induced Immunosuppression, Abraham Quaye
Theses and Dissertations
Turkey hemorrhagic enteritis virus (THEV) is an adenovirus (AdV) that causes hemorrhagic enteritis (HE) in turkeys, a debilitating disease affecting predominantly 6-12-week-old turkey poults characterized by immunosuppression (IMS) and intestinal lesions leading to bloody diarrhea. Although a naturally-occurring avirulent THEV strain has been adopted as live vaccine and has proven effective at preventing HE in turkeys, it still retains its immunosuppressive ability. Thus, vaccinated birds are rendered more susceptible to opportunistic infections and death than unvaccinated cohorts, leading to substantial economic losses. This dissertation focuses on elucidating both host and viral factors mediating THEV-induced IMS in turkeys. As THEV gene …
Angioedema: Is Icu Admission Warranted? A Single Institution Assessment, Madeleine Brill-Edwards, W. Chase Hamilton, Erika J. Yoo, Jennifer Costello, George J. Koenig, Murray J. Cohen, Joshua A. Marks
Angioedema: Is Icu Admission Warranted? A Single Institution Assessment, Madeleine Brill-Edwards, W. Chase Hamilton, Erika J. Yoo, Jennifer Costello, George J. Koenig, Murray J. Cohen, Joshua A. Marks
Department of Surgery Faculty Papers
INTRODUCTION: Angioedema has potential for rapid airway decompensation requiring intervention. Patients are often admitted to an ICU for "airway watch." There is a lack of evidence to support which patients require this.
AIM: We aimed to characterize admission patterns and outcomes of angioedema patients at our institution to assess resource utilization and necessity of ICU use. We hypothesized that patients not requiring intubation upon presentation are safe to manage outside the ICU.
MATERIALS AND METHODS: Retrospective chart review of patients admitted to our urban academic quaternary referral institution with angioedema ICD-10 codes between 2017 and 2020. Charts reviewed for demographics, …
The Influence Of Rhodolith Algae On Life History Of The Painted Urchin, Lytechinus Pictus, Celine X. De Jong
The Influence Of Rhodolith Algae On Life History Of The Painted Urchin, Lytechinus Pictus, Celine X. De Jong
Master's Theses
Rhodolith beds are globally distributed hotspots of diversity and productivity and serve as nursery habitats for some marine invertebrates. Poorly understood is whether rhodolith beds are nurseries because invertebrate larvae actively select them for settlement or migrate to them at later life stages. We studied the nursery role of rhodolith beds for the painted urchin, Lytechinus pictus at Santa Catalina Island, CA, USA. Subtidal surveys showed that in areas with greater live rhodolith cover, urchin density increased as well as mean urchin size. In caged substrate choice experiments, urchins selected rhodolith substrate relative to carbonate sand, supporting the notion that …
Direct And Indirect Associations Of Childhood Adversities With Functional Impairment And Life Stress Among Military Personnel, Laura Campbell-Sills, Emily R. Edwards, Sam D. Strizver, Karmel W. Choi, Jason D. Kautz, Santiago Papini, James A. Naifeh, Pablo A. Aliaga, Paul B. Lester, Ronald C. Kessler, Robert J. Ursano, Murray B. Stein, Paul D. Biese
Direct And Indirect Associations Of Childhood Adversities With Functional Impairment And Life Stress Among Military Personnel, Laura Campbell-Sills, Emily R. Edwards, Sam D. Strizver, Karmel W. Choi, Jason D. Kautz, Santiago Papini, James A. Naifeh, Pablo A. Aliaga, Paul B. Lester, Ronald C. Kessler, Robert J. Ursano, Murray B. Stein, Paul D. Biese
Faculty Publications
Background
Adverse childhood experiences (ACEs) are associated with physical and mental health difficulties in adulthood. This study examines the associations of ACEs with functional impairment and life stress among military personnel, a population disproportionately affected by ACEs. We also evaluate the extent to which the associations of ACEs with functional outcomes are mediated through internalizing and externalizing disorders.
Methods
The sample included 4,666 STARRS Longitudinal Study (STARRS-LS) participants who provided information about ACEs upon enlistment in the US Army (2011–2012). Mental disorders were assessed in wave 1 (LS1; 2016–2018), and functional impairment and life stress were evaluated in wave 2 …
Characterizing Gastric Cancer Tumor Immune Microenvironment Through Extracellular Vesicles, Claire Elizabeth Bruno
Characterizing Gastric Cancer Tumor Immune Microenvironment Through Extracellular Vesicles, Claire Elizabeth Bruno
Theses and Dissertations
The tumor immune microenvironment (TIME) critically influences cancer progression and determining therapeutic response. As immunotherapies continue to improve and reshape cancer treatments, there is a need for tools that can more efficiently and accurately assess and monitor the TIME. Extracellular vesicles (EVs), especially small EVs (sEVs), are lipid-bound nanoparticles that carry proteins, DNA, and RNA reflective of their cell of origin, offering a novel, non-invasive biomarker of the TIME. This makes them a promising candidate for immune profiling and treatment monitoring in cancer. This thesis investigates the potential of EVs as biomarkers for TIME composition and immune activity. An analysis …
Assessment Of Covid-19 Risks Related To Behaviour And Body Resistance In The Remote Area: Case Study In Jeneponto, Basri Basri, Andi Tilka Muftiah Ridjal, Lukman Setiawan, Renaldi M
Assessment Of Covid-19 Risks Related To Behaviour And Body Resistance In The Remote Area: Case Study In Jeneponto, Basri Basri, Andi Tilka Muftiah Ridjal, Lukman Setiawan, Renaldi M
Journal of Environmental Science and Sustainable Development
COVID-19 has posed significant global health threats, with responses varying across populations due to differences in risk perception, behaviour, and biological vulnerability. In Indonesia, most research has focused on urban settings, with limited attention paid to rural or remote communities. This study assesses COVID-19- risks related—specifically behavioural and immunity-related-factors—in the remote area of both Bontoramba Subdistrict, Jeneponto Regency. A cross-sectional study was conducted using cluster random sampling across eight villages, with 183 participants selected from a total of 12,242 households. Data were collected between November to December 2020 using a validated structured questionnaire, administered both online and face-to-face interviews. The …
Genome Sequences For Nine Streptococcus Anginosus Strains Isolated From Female Urogenital Samples, Helen Appleberry, Olive Kolar, Saad Ahmed, Omar Al Khalili, Inga Astrauskas, Adel Choubkha, Abraham Dulli, Anna Gamal, Elina Greljo, Samiah Iqbal, Neelesh Kanduri, Adam Kawamleh, Emma Kress, Walter Mccain, Sophia Meza, Madison Mikolaitis, Amal Naqvi, Emily Ngo, Jackie Ostiguin, Vedant Patel, Alan J. Wolfe, Catherine Putonti, Alex Kula
Genome Sequences For Nine Streptococcus Anginosus Strains Isolated From Female Urogenital Samples, Helen Appleberry, Olive Kolar, Saad Ahmed, Omar Al Khalili, Inga Astrauskas, Adel Choubkha, Abraham Dulli, Anna Gamal, Elina Greljo, Samiah Iqbal, Neelesh Kanduri, Adam Kawamleh, Emma Kress, Walter Mccain, Sophia Meza, Madison Mikolaitis, Amal Naqvi, Emily Ngo, Jackie Ostiguin, Vedant Patel, Alan J. Wolfe, Catherine Putonti, Alex Kula
Biology: Faculty Publications and Other Works
Streptococcus anginosus is a common inhabitant of the female urinary tract. Comparative genomics suggests that strains from female urogenital samples are distinct from S. anginosus strains isolated from other anatomical sites. Here, we present three complete and six draft genome assemblies of S. anginosus isolated from urine, vaginal swabs, and a perineal swab.
Identification Of Crustose Coralline Algae Species In Florida And Their Ability To Induce Larval Settlement Of Caribbean Corals, Danielle Macias
Identification Of Crustose Coralline Algae Species In Florida And Their Ability To Induce Larval Settlement Of Caribbean Corals, Danielle Macias
All HCAS Student Capstones, Theses, and Dissertations
Crustose coralline algae (CCA) are a diverse, globally spread and yet poorly studied group of benthic organisms. They act as settlement cues for coral larvae, but this interaction is often species-specific, as CCA species can be either inducers or inhibitors to larval settlement and metamorphosis. Despite this importance, information on Caribbean CCA distribution, diversity, and impact on coral species is limited due to the difficulty in identifying them. In the present study, CCA samples were collected from seven different reef sites in the southeastern region of Florida’s Coral Reef and genetically identified using molecular analyses. Some of the samples collected …
Effective And Eco-Friendly Strategies To Control Birds In Industrial Estate, Jasti Rahayu, Upik K. Hadi, Susi Soviana
Effective And Eco-Friendly Strategies To Control Birds In Industrial Estate, Jasti Rahayu, Upik K. Hadi, Susi Soviana
Journal of Environmental Science and Sustainable Development
Bird infestations in industrial areas can cause infrastructure damage, contamination, and health risks. Despite these impacts, they are rarely addressed in environmental management strategies. At the Kaltim Industrial Estate (KIE) in Bontang, East Kalimantan, synanthropic bird species that thrive in human-altered environments have become persistent nuisances, particularly because of structural opportunities for roosting and altered ecological conditions. To address this issue, this study applied Integrated Pest Bird Management (IPBM), a non-lethal and environmentally friendly approach that combines species identification, behavior analysis, and targeted deterrents. IPBM was selected for its adaptability to industrial settings and its alignment with sustainable development goals. …
Coal Mining Reclamation: Lessons Learned From Tropical And Subtropical Countries, Priyaji Agung Pambudi, Suyud Warno Utomo, Roni Setyo Handoko
Coal Mining Reclamation: Lessons Learned From Tropical And Subtropical Countries, Priyaji Agung Pambudi, Suyud Warno Utomo, Roni Setyo Handoko
Journal of Environmental Science and Sustainable Development
This study addresses the persistent environmental challenges associated with coal mining in tropical and subtropical regions, where complex microclimates and ecological variability hinder effective reclamation. Despite the increasing global coal demand, comparative cross-country insights remain limited. This research fills the gap by evaluating the best practices. This study employs a qualitative methodology with a comparative case study design, uses systematic literature review to evaluate ecology based reclamation policies and implementation practices. Data were sourced from peer-reviewed journals from Scopus and the Web of Science database and institutional reports, and analyzed using McHarg’s landscape ecology theory to evaluate reclamation policies, ecological …
Role And Use Of Race In Artificial Intelligence And Machine Learning Models Related To Health, Martin C Were, Ang Li, Bradley A Malin, Zhijun Yin, Joseph R Coco, Benjamin X Collins, Ellen Wright Clayton, Laurie L Novak, Rachele Hendricks-Sturrup, Abiodun O Oluyomi, Shilo Anders, Chao Yan
Role And Use Of Race In Artificial Intelligence And Machine Learning Models Related To Health, Martin C Were, Ang Li, Bradley A Malin, Zhijun Yin, Joseph R Coco, Benjamin X Collins, Ellen Wright Clayton, Laurie L Novak, Rachele Hendricks-Sturrup, Abiodun O Oluyomi, Shilo Anders, Chao Yan
Faculty, Staff and Students Publications
The role and use of race within health-related artificial intelligence (AI) and machine learning (ML) models have sparked increasing attention and controversy. Despite the complexity and breadth of related issues, a robust and holistic framework to guide stakeholders in their examination and resolution remains lacking. This perspective provides a broad-based, systematic, and crosscutting landscape analysis of race-related challenges, structured around the AI and ML life cycle and framed through "points to consider" to support inquiry and decision-making.
Modulation Of Biomolecular Aggregate Morphology And Condensate Infectivity.Modulation Of Biomolecular Aggregate Morphology And Condensate Infectivity, Josephine C Ferreon, Kyoung-Jae Choi, My Diem Quan, Phoebe S Tsoi, Cristopher C Ferreon, Ulas Coskun, Shih-Chu Jeff Liao, Allan Chris M Ferreon
Modulation Of Biomolecular Aggregate Morphology And Condensate Infectivity.Modulation Of Biomolecular Aggregate Morphology And Condensate Infectivity, Josephine C Ferreon, Kyoung-Jae Choi, My Diem Quan, Phoebe S Tsoi, Cristopher C Ferreon, Ulas Coskun, Shih-Chu Jeff Liao, Allan Chris M Ferreon
Faculty, Staff and Students Publications
Neurodegenerative diseases are characterized by pathological aggregates exhibiting distinct morphologies, such as neurofibrillary tangles and dense circular Lewy body-like structures in Alzheimer's disease, and round hyaline gel-like inclusions and skein-like filaments in amyotrophic lateral sclerosis. However, the mechanisms driving the formation of these diverse morphological structures remain poorly understood. Employing advanced microscopy, including fluorescence lifetime imaging, we investigated condensate aging and aggregation mechanisms of the prion-like domain of hnRNPA1 (A1PrD), a ribonucleoprotein implicated in both disorders. Using a simplified system across various salt and RNA conditions, we demonstrate that homotypic and heterotypic interactions between A1PrD and RNA significantly influence aggregate …