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Identification Of Anti-Inflammatory Pathways Induced By Enterotoxin B Subunits For Use As Therapeutics In Inflammatory Bowel Disease, Hannah Juel Hedelius

Boise State University Theses and Dissertations

Vibrio cholerae’s AB5 enterotoxin, cholera toxin (CT), has a homopentameric, non-toxic B subunit (CTB). CTB is a well-known vaccine adjuvant used for its ability to create a strong immune response, however more recent studies have shown its ability to also behave in an anti-inflammatory manner, performing as a protective agent in a variety of different inflammatory diseases. Escherichia coli (E. coli) produces a heat-labile AB5 enterotoxin (LT) that is very homologous to CT, with its B subunit (LTB) being used in a similar manner as a vaccine adjuvant. There have been many studies comparing LTB to CTB due …

Social And Economic Gradients Of Resource Transfer Behavior In Gorongosa, Mozambique, Karl J. Mertens

Boise State University Theses and Dissertations

Why do people who experience the same environmental and social conditions vary so much in their resource transfer behavior? This dissertation addresses that question through examination of behavioral variation in subsistence horticulturalists in the dry tropical forest bufer conservation area of Gorongosa National Park in Mozambique. In this region of moderate and acute food shortages at both household and regional levels, individuals face similar challenges of addressing social and resource uncertainty yet respond with marked behavioral variation that cannot be explained solely by diferences in wealth, kinship, or reciprocity patterns.

Using a Behavioral Reaction Norms (Dingemanse et al., 2010) (BRN) …

Risk Perceptions And Water Governance: Experiences Of Irrigation Companies In The Great Salt Lake Basin Of Northern Utah, United States, Bailey M. Holdaway

All Graduate Theses and Dissertations, Fall 2023 to Present

Irrigation companies are important water management entities in the Western US. However, these companies often face barriers when managing water. Particularly as the state of Utah grows and water resources are drying, there is much finger pointing at those in irrigation and agriculture for better water management. However, pointing fingers without the participation of these companies often does not lead to effective water management outcomes. Therefore, it is important to understand the role of these irrigation companies, and particularly how they are approaching water management.

I set out to understand the role of these irrigation companies, specifically in the Great …

An Embodied Social Demography For Trans And Nonbinary Workers, Jesse Ezra Shircliff

All Graduate Theses and Dissertations, Fall 2023 to Present

Recently, the separation of “sex” and “gender” has seen intense debate in public discourse, stemming from skepticism about the social sciences and the measurement and study of gender specifically. Meanwhile, the United States population is becoming more gender diverse, with roughly 1 in 200 people now identifying as trans gender or gender nonbinary (that is, as a gender that is different from that person’s sex assigned-at-birth or outside of the sex-gender binary). This growing population experiences numerous disadvantages across social life, including obstacles in one particularly important aspect of the American Dream: the right to have and hold a job. …

Optimizing Delphinium And Larkspur Through Timing And Protective Cultivation Methods For Cut Flower Production, Nicholas Kirwan Volesky

All Graduate Theses and Dissertations, Fall 2023 to Present

Cut flowers have become an increasingly important specialty crop for small farms nationwide, and particularly in Utah, where decreasing agricultural land has heightened the need for profitable cropping options. However, production is challenged by Utah’s high-elevation climate, which presents unique constraints not addressed by current recommendations. Cool-season crops, like delphinium (Delphinium spp.) and larkspur (Consolida ajacis L.), are underproduced yet highly marketable, generating strong interest among growers throughout the state. Developing region-specific production guidelines is essential to help optimize yields, extend harvest windows, and meet local demand. This research evaluated spring planting dates in high tunnel and field …

Habitat Selection Analysis Of Mule Deer To Determine Efficacy Of The Coyote Bounty Program In Utah, Xaela M. Walden

All Graduate Theses and Dissertations, Fall 2023 to Present

Mule deer populations have been declining over the past couple of decades in many parts of the western United States. Often times, predators are blamed for the decreases in deer populations. Because of this, wildlife managers implement programs focused on reducing the number of predators on the landscape in an attempt to increase deer populations. However, predator removal programs have had mixed results, thus further investigation is needed to determine if coyote removals by the public through a bounty program have a positive effect on mule deer populations. My study investigated whether coyote removals through the bounty program in Utah …

Parenting For Wellness: Positive Parenting Factors As Predictors Of College Student Physical Health, Mental Health, And Social Connectedness Through The Lens Of Self-Determination Theory, Mary E. Lamkin

Dissertations

Research suggests that the transition to college can impact college student well-being across the domains of physical health, mental health, and social connectedness (Frech, 2012; Pittman & Richmond, 2008; Xiao et al., 2017). As parents are more heavily connected to their college-aged students when compared to years before cell phones and social media, they likely continue to play a significant role in their child’s well-being, even while they are in college (Wartman & Savage, 2008). Therefore, the aim of this dissertation was to investigate positive parenting behaviors as predictors of wellness in college-aged participants using Self Determination Theory (Ryan & …

Coyote (Canis Latrans) And Non-Target Wildlife Responses To Livestock Guardian Dogs At Sheep Grazing Sites On The California Central Coast, Tricia T. Nguyen

Master's Theses

Livestock depredation is one of the oldest and most widespread forms of human-wildlife conflict. The coyote (Canis latrans), a midsized canid, represents a significant proportion of domestic sheep depredations in the United States, costing livestock producers an estimated 24.6 million dollars annually. Management strategies for coyote-sheep depredation vary widely in their effectiveness and in their level of public support. Identifying appropriate strategies for farms, ranches, and other sheep grazing sites remains a pressing need due to the potentially negative consequences for surrounding ecosystems and socioeconomic outcomes for sheep producers. The livestock guardian dog (LGD) is a nonlethal control …

Microbial Guardians Of The Savannah: Unraveling The Gut Microbiome For African Carnivore Conservation, Laura E. Peirson

All NMU Master's Theses

Non-invasive fecal sampling is essential for wildlife gut microbiome (GMB) research, yet field conditions often limit preservation options. I compared gut bacterial communities in paired fecal samples preserved in stabilization tubes and air-dried in paper bags collected from anesthetized African lions (Panthera leo) and spotted hyenas (Crocuta crocuta) in Etosha National Park, Namibia. Additional opportunistic samples from carnivore kill sites were also analyzed. No significant differences in alpha or beta diversity were detected between preserved and dried samples, although bacterial beta diversity differed between preserved and opportunistic samples (PERMANOVA). Core bacterial communities remained consistent across sample …

Dean's Research Newsletter, August 2025, Neil W. Schluger

SOM Dean's Research Newsletter

No abstract provided.

Crevice Corrosion Mechanisms Of Cocrmo Alloys In Orthopedic Implants: Retrieval Analysis, Nano-Tribocorrosion And Cellular Responses, Hwaran Lee

All Dissertations

Mechanically assisted corrosion and non-mechanically (chemically) driven corrosion in modular junctions of orthopedic implants using cobalt-chromium-molybdenum (CoCrMo) alloys remain clinical concerns and may contribute to implant failure. The underlying corrosion mechanisms are not yet fully understood, leaving a critical research gap. We hypothesized that corrosion in modular junctions may be driven by aggressive local environments, including fretting, metal ion release (cobalt ion, Co²⁺), low pH and reactive oxygen species (ROS). This dissertation aims to (1) analyze corrosion modes and potential causes in modular junctions; (2) identify chemically driven corrosion modes on CoCrMo alloys using simulated inflammatory modular taper …

An Examination Of How Black Church Leaders Support The Long-Term Impact Of Trauma In The Black Community: A Qualitative Transcendental Phenomenological Study, Loretha J. Mccullough

Education Doctoral

The prevalence of mental illness due to untreated childhood trauma continues to be a concern, particularly for Black people. The consequence of obtaining formal treatment is perceived to be discriminatory and stigmatizing in the Black culture. Instead, the preferred method of treatment is religious coping. The purpose of this transcendental phenomenological study was to examine how Black clergy leaders support the long-term impact of trauma in the Black community. The primary source of data collection was semi-structured interviews. These interviews captured the essence of how Black clergy leaders described their preparedness to effectively advise, and counsel congregants on mental health …

Madam President: Navigating The Journey Of Black Women To Executive Leadership In Higher Education, Tressi Daymon

Education Doctoral

The purpose of this phenomenological qualitative study is to examine the leadership trajectories of Black women in senior executive roles in higher education, with a focus on the barriers and supports that have shaped their careers. Semi-structured interviews gathered perspectives on their lived experiences, capturing both the challenges they faced and the strategies used in their journeys. These strategies included networking, skill-building, advocacy, and resilience, reflecting how these women navigated and overcame the unique leadership challenges they faced. Black feminist theory and intersectionality provided the theoretical framework to explore how race and gender biases uniquely affected their leadership journeys. Data …

Examining Employers’ Perspectives Relating To Early College High School Programs And Employability Skills, Kathleen Mcguigan

Education Doctoral

This phenomenological qualitative research study examined employer perspectives on the employability skills of graduates from Early College High School (ECHS) programs. The study investigated the program components that enhance the preparation of employability skills and the systems that support graduate transition to the workforce. Using semi-structured interviews with employer partners and an iterative coding process, three key themes emerged across the data. The key themes highlight the importance of factors relating to workplace readiness, including internships and experiential learning, behavioral and soft skills, and structured transition systems, as critical components in preparing ECHS graduates for employment.

The findings indicate that …

Factors Underlying A Latitudinal Gradient In The S/G Lignin Monomer Ratio In Natural Poplar Variants, Jin Zhang, Pradeep Kumar Prabhakar, Yen On Chan, Rachel A. Weber, Mengjun Shu, Ganesh Panzade, Connor J. Cooper, Russell B. Davidson, Jin-Gui Chen, Sara S. Jawdy, Jerry M. Parks, Breeanna R. Urbanowicz, Gerald A. Tuskan, Trupti Joshi, Richard A. Dixon, Wellington Muchero, Jaime Barros

Biomedical Sciences

The chemical composition of wood plays a pivotal role in the adaptability and structural integrity of trees. However, few studies have investigated the environmental factors that determine lignin composition and its biological significance in plants. Here, we examined the lignin syringyl-to-guaiacyl (S/G) ratio in members of a Populus trichocarpa population sourced from their native habitat and conducted a genome wide association study to identify genes linked to lignin formation. Our results revealed many significant associations, suggesting that lignin biosynthesis is a complex polygenic trait. Additionally, we found an increase in the S/G ratio from northern to southern geographic origin of …

Analysis Of The Scleroderma / Systemic Sclerosis Etiopathology Using The University Of California At Davis (Ucd)-Ssc Chicken Line, Angeline E. Rodriguez

Graduate Theses and Dissertations

Scleroderma/Systemic Sclerosis (SSc) is a multifaceted autoimmune disorder affecting approximately 300,000 people in the United States. Main features include vasculitis, immune dysfunction (innate and adaptive), autoantibody production, perivascular leukocyte infiltration, and extensive tissue fibrosis. The University of California, Davis (UCD) SSc chicken line was shown to exhibit all clinical and biological manifestations of human SSc. One early and distinctive clinical sign in both humans and UCD-SSc chickens is Raynaud’s phenomenon (RP), characterized by decreased blood flow in extremities and skin lesions. RP-like lesions develop in combs of UCD-SSc chickens within one- to two-weeks post-hatch, progressing from erythema and edema to …

Framing The Problem To Meet The Policy Solution: An Embedded Mixed Methods Case Study Of The 2017 Michigan Opioid Laws, Leandra Hawkins Burke

Dissertations

The opioid crisis presents a wicked problem for public administration. Hundreds of thousands of people have died from opioid overdoses in the United States, and countless others have experienced severe opioid-related physical, psychological, and socioeconomic harms. Countering the opioid crisis has been difficult due to interdependencies across different drugs and multiple pathways for abuse and dependence. Many scholars, health providers, and politicians have called for a broad public health approach to combat the opioid crisis, but the full expanse of what that would entail has not yet been realized. What has been demonstrated is that interactions targeting a single aspect …

Mechanistic And Evolutionary Insights Into A Group Of Nicotine And Hydroxynicotine Degrading Flavoenzymes, Zhiyao Zhang

Dissertations

Flavoprotein amine oxidases (FAOs) are key enzymes in various kinds of metabolic pathways, mediating redox reactions via flavin cofactors. While most FAOs function as oxidases that readily reduce oxygen to hydrogen peroxide, a few outliers of the FAO family act as dehydrogenases that suppress the reaction with oxygen. The molecular basis for this divergence in function remains poorly understood.

The work presented in this study investigates the fundamental mechanisms of how flavincontaining enzymes activate or suppress their reaction with different electron acceptors to achieve high turnover rates. The overall body of work is divided into three different sections that (1) …

Interdisciplinary Studies At Grand Valley State: Brooks College At Twenty, Eric Covey

Grand Valley Reports and Histories

This study, focused chiefly on academic programs, begins with a brief outline of the history of the Cluster Colleges at Grand Valley State University and then goes on to detail how the arrival of a new provost in 2002 revived and reshaped the idea of an independent college dedicated to interdisciplinary experiments. It was written partially to commemorate the 20th anniversary of Brooks College of Interdisciplinary Studies.

Counteracting Cascades Challenge The Heterogeneity-Stability Relationship, Jordi Sola, Tom P. Fairchild, Matthew J. Perkins, James C. Bull, John N. Griffin

School of Biological and Marine Sciences

Spatial environmental heterogeneity is widely assumed to enhance ecological stability by promoting refugia, biodiversity and asynchrony. Yet, we lack field experiments testing this fundamental relationship and its underlying mechanisms in naturally assembled multitrophic systems. To address this gap, we monitored experimental substrates replicating topographic heterogeneity on a rocky shore over 3 years. Contrary to theory, heterogeneity showed no net effect on community stability due to four counteracting pathways. Heterogeneity increased stability by (i) providing refugia that enhanced population stability and (ii) boosting species richness, which promoted asynchrony. At the same time, it decreased stability by (iii) reducing a dominant non-native …

Digital Biophilia In Web Interface Design For Accessibility And User Well-Being, Bryana Michelle Peifer

Theses

This interdisciplinary study explores the intersection between horticultural therapy and web design, focusing on the impact of biophilic design principles in shaping contemporary practices within digital interface design. This exploration addresses the multifaceted relationship between humanity and the natural world, particularly how this connection serves as a source for the emergence of nature-inspired elements in digital expressions and their subsequent integration into modern web design for accessibility and well-being. As digital environments increasingly dominate daily experiences, the need for digital wellness through nature integration has become critical, especially for individuals who have physical disabilities, limited mobility, or limited access to …

A Tale Of Two Toxicants: Investigating The Interaction Between Hexavalent Chromium And Perfluorooctane Sulfonic Acid., Morgan Elizabeth Delnicki

Electronic Theses and Dissertations

Hexavalent chromium [Cr(VI)] and per- and polyfluoroalkyl substances (PFAS) are environmental contaminants of major public health concern. Despite commonly being found together in contaminated drinking water, no studies have considered the concomitant health effects of Cr(VI) and PFAS, specifically perfluorooctane sulfonic acid (PFOS). In vitro studies using CHO cells assessed the cytotoxicity and genotoxicity of Cr(VI) and PFAS both individually and in combination. Intracellular and extracellular Cr levels were measured with Atomic Absorption Spectrometry. PFOS was found to exacerbate Cr(VI) induced cytotoxicity and genotoxicity. Additionally, a novel in vivo model of studying the hepatotoxicity of Cr(VI) was established. Adult Hartley …

Exploring Hexavalent Chromium Exposure And Lipid Accumulation In Liver Disease., Gabrielle Celine Griffin

Electronic Theses and Dissertations

The prevalence of MASLD has doubled over the past 20 years and continues to rise. Hexavalent chromium [Cr(VI)], a top chemical hazard in U.S. drinking water, is emerging as potential risk factor for liver disease. To study the impact of Cr(VI) and high-fat diet on MASLD, we developed an in vivo model using Sprague-Dawley rats exposed to Cr(VI) in drinking water (0, 0.05, or 0.1 mg/L) and fed normal or high-fat diet for 90 days. High-fat diet significantly increased body mass, plasma lipoproteins, cholesterol, liver injury, and hepatic triglycerides, which were exacerbated by Cr(VI) exposure. Cr(VI) alone increased hepatic chromium …

An Exploration Of Lgbtq+ Runner Motivation And Constraints., Michael Clemons

Electronic Theses and Dissertations

Running offers extensive benefits beyond physical fitness, encompassing mental, emotional, and social advantages. However, LGBTQ+ individuals face unique challenges in participating in the running community, which remains predominantly White, cisgender, and heterosexual. With the LGBTQ+ population in the U.S. growing, there is a need to understand their motivations and barriers to participation in running events and training groups. This study explores these motivations using self-determination theory, comparing LGBTQ+ and non-LGBTQ+ runners to identify differences in driving factors such as social connectivity, self-esteem, and competition. Additionally, it examines barriers LGBTQ+ runners face, ranging from structural obstacles to intrapersonal challenges, and how …

Analysis Of An Ethanol Sensitive Bmp-Nkx2.3-Fgf Signaling Pathway In Pouch Morphogenesis., Hieu Dai Le Vo

Electronic Theses and Dissertations

Craniofacial malformations lie at the heart of Fetal Alcohol Spectrum Disorders (FASD). While there is growing evidence for a genetic component to FASD, little is known of the cellular mechanisms underlying these ethanol-sensitive loci in facial development. Bone Morphogenetic Protein (Bmp) signaling pathway dependent pouch formation is a key mechanism in facial development. We have previously shown that multiple Bmp mutants are sensitized to ethanol-induced facial defects. However, ethanol does not directly impact Bmp signaling. This suggests that downstream effectors, like nkx2.3 and Fibroblast Growth Factor (Fgf) signaling, may mediate the impact of ethanol on Bmp mutants. Here, I …

Human Salivary Gland Stem/Progenitor Cells For Tissue Engineering, Sars-Cov-2 Susceptibility, And Neurointegration, Caitlynn Barrows

Dissertations and Theses (Open Access)

Salivary glands and the saliva they secrete are important for digestion, chewing, and maintaining oral health. Reduced saliva production leads to a decreased quality of life for patients experiencing hyposalivation as a result of disease or injury, thus a large effort has been dedicated to developing materials and medium to recapitulate the structure of the gland for regenerative medicine. In doing so, we have come closer to developing a more complex model to study disease. These models, however, do not yet fully recapitulate the gland. In this dissertation, we describe a new cell source that can be used to develop …

Integrating Bulk And Single-Cell Transcriptomics To Investigate Intratumor Heterogeneity, Shuai Guo

Dissertations and Theses (Open Access)

Cancers are heterogeneous mixtures of tumor and surrounding cells, where each component comprises multiple distinct sub-types and/or states. Understanding the cell-type-specific contributions is critical for advancing cancer biology, yet high-throughput expression profiles from tumor tissues only represent combined signals from all diverse cellular sources. Bulk deconvolution with single-cell/nucleus (sc/sn) RNA-seq data has emerged as a powerful approach to dissect both cellular composition and cell-type-specific expression patterns, yet the technological discrepancy across sequencing platforms limits accuracy.

To systematically evaluate the impact of platform discrepancies on bulk deconvolution, we first generated a benchmark dataset of 24 healthy retinas with paired bulk and …

Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression During Immunotherapy, Er-Yen Yen

Dissertations and Theses (Open Access)

Tumors are dynamic ecosystems that evolve under selective pressures, shaping their ability to either elicit or evade immune responses. In pancreatic ductal adenocarcinoma (PDAC), where immunotherapy has yet to become an effective treatment option, we investigated the role of intratumoral heterogeneity in influencing immune interactions. Using orthotopic clonal replica tumors, we tracked clonal dynamics in response to anti-PD1 therapy and found that while treatment had limited impact on overall tumor volume, it induced profound shifts in clonal composition. Spatial lineage analysis of treatment-naïve tumors revealed that clones with distinct immunotherapy sensitivities occupy unique tumor microenvironments, a pattern that remained stable …

Chronic Cluster Headache Is A Rare Disease: Implications For Diagnosis, Treatment And Public Health, Hsiangkuo Yuan, Jan Hoffmann, Elena Ruiz De La Torre, Michael J. Marmura, Mario F. P. Peres

Department of Jefferson Headache Center Papers and Presentations

Cluster headache (CH) is a rare and painful primary headache disorder characterized by severe unilateral pain and cranial autonomic symptoms. This perspective examines the epidemiological evidence supporting the classification of chronic cluster headache (CCH) as a rare disease, noting a prevalence of CH of approximately 124 per 100,000 individuals, with only 3.5-13.7% manifesting CCH. This prevalence meets criteria established by both the US Food and Drug Administration and European Medicines Agency for rare disease designation. The rarity of CCH creates substantial clinical and research challenges, including prolonged diagnostic delays, limited research funding and a dearth of approved treatments. The economic …

Onair: Applications Of The Nasa On-Board Artificial Intelligence Research Platform, Evana Gizzi, Conner Firth, Caleb Adams, James Berck, P. Timothy Chase Jr., Christian Cassamajor-Paul, Rachael Chertok, Lily Cloug, Jonathan Davis, Melissa De La Cruz, Matthew Dosberg, Alan Gibson, Jonathan Hammer, Ibrahim Haroon, Michael A. Johnson, Brian Kempa, James Marshall, Patrick Maynard, Brett Mckinney, Leyton Mckinney, Michael Monaghan, Robin Onsay, Hayley Owens, Sam Pedrotty, Daniel Rogers, Mahmooda Sultana, Jivko Sinapov, Bethany Theiling, Aaron Woodard, Caroline Zouloumian

Computer Science: Student Work

Infusing artificial intelligence algorithms into production aerospace systems can
be challenging due to costs, timelines, and a risk-averse industry. We introduce
the Onboard Artificial Intelligence Research (OnAIR) platform, an open-source
software pipeline and cognitive architecture tool that enables full life cycle AI
research for on-board intelligent systems. We begin with a description and user
walk-through of the OnAIR tool. Next, we describe four use cases of OnAIR for
both research and deployed onboard applications, detailing their use of OnAIR
and the benefits it provided to the development and function of each respective scenario. Lastly, we describe two upcoming planned deployments …