Hormonal Modulation Of Sexual Approach And Avoidance Among Women With A History Of Sexual Trauma, Anneliis Susan Sartin-Tarm

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

A history of sexual trauma places women at a high risk for sexual dysfunction and other health sequelae, yet the influence of ovarian hormones in this population is poorly understood. This dissertation tested the theory that the effects of ovarian hormones are mediated by cognitive approach-avoidance systems to shape sexual well-being, and that this process is moderated by sexual trauma history. This was investigated across three studies examining the menstrual cycle, hormonal contraceptive use, and menopause. Across each chapter, I present complementary evidence demonstrating that hormones interact with the interpretation of ambiguous internal and external cues with respect to sexual …

Reductive And Nucleophilic Cleavage Of Peroxides And Synthesis Of Tocotrienols As Radioprotective Targets, Amber Marie Schuster

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

I. SET CLEAVAGE OF PEROXIDES: INFLUENCE OF REDUCTANT AND PEROXIDE ON THE RATE AND MODE OF ALKOXY RADICAL FORMATION

The reductive cleavage of organic peroxides to generate alkoxy radicals is frequently accomplished via single-electron transfer (SET) from a reductant. Previous reports employ either symmetrical peroxides or peroxides with predictable cleavage behavior, such as peresters. We were interested in how the structure of the peroxide and the nature of the reducing system combine to impact the rate of reaction and the selectivity for alkoxy radical formation during cleavage of unsymmetric peroxides. In this dissertation, one will find the reactions of a …

Educating The New Generation Of Food Scientists Through Innovative Learning Experiences, Karen Andrea Nieto Flores

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Food science provides an opportunity to engage high school students in Science, Technology, Engineering, and Mathematics (STEM) by connecting classroom concepts to real-world applications. Despite the field’s relevance to public health, food safety, sustainability, and innovation, food science remains largely absent from high school curricula, and few students recognize it as a viable STEM pathway. This research addressed this gap by evaluating immersive summer camp experiences and teacher-focused curriculum review as strategies to increase food science awareness and interest among students and educators. A literature review traced the historical development and current landscape of K–12 food science education, identifying barriers …

Egg White Hydrolysate In Hypertension: A Mechanistic Investigation Of Gut Microbiota Dependent And Independent Pathways, Emerson David Nolasco

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Cardiovascular diseases are one of the leading causes of mortality worldwide in which hypertension is a risk factor. Present pharmacological interventions require long-term adherence to the therapy and are often associated with undesirable side effects. Moreover, treatments have overlooked the role of the microbiome in the development of hypertension. Egg white hydrolysate (EWH) has exhibited antihypertensive properties with potential to be used as a natural alternative for the prevention and management of hypertension. However, EWH peptide’s effect on the gut microbiome remains yet to be elucidated. Studies have described that a portion of the ingested protein can remain undigested as …

Functional Genomics Of Phosphatidylcholine Biosynthesis In Saccharomyces Cerevisiae, Amanda Marie Maliva

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Phosphatidylcholine (PtdCho) is a prominent structural building block of cell and organelle membranes in animal, plant, and fungal cells and some bacteria. Due to its abundant nature in the plasma membrane and intracellular organelle membranes in eukaryotes, the biosynthesis of PtdCho must remain regulated to preserve the correct membrane lipid composition. Dysregulations in PtdCho metabolism can lead to mitochondrial dysfunction, cell death, and the development of diseases including cancer, atherosclerosis, and hepatic diseases. Knowledge of PtdCho has remained limited to the genes involved in its three biosynthetic pathways (Kennedy (K), methylation (M), and acyltransferase (A)), despite the growing realization of …

Characterization Of Undergraduate Biology Instructors’ Goals And Strategies For Implementing Quantitative Reasoning, Anum Khushal

School of Natural Resources: Dissertations, Theses, and Student Research

Quantitative reasoning (QR) is the application of mathematics and statistics to real-life and scientific contexts. It is essential for understanding complex biological phenomena and analyzing large datasets in both academic and professional settings. In response to the growing demand for QR skills, biology educators and researchers have engaged in curricular reforms and education research. This qualitative study explores how undergraduate biology instructors integrate QR into their teaching using a framework informed by pedagogical content knowledge (PCK) and QR. The study involved 21 biology faculty from various U.S. institutions who intentionally incorporated QR in their instruction. Data was collected through semi-structured …

Multiscale Drivers Of Water Level Fluctuations And Nutrient Availability In Small Intermittent Reservoirs In The Us Midwest, Uchechukwu Vitus Chinatu Ogbenna

School of Natural Resources: Dissertations, Theses, and Student Research

Reservoir dynamics are often captured by fluctuations in water surface elevation, which reflect a complex interplay of hydrologic inputs, climatic conditions, land use influences, and management operations. While water level fluctuations (WLFs) in large regulated systems have been widely studied, the drivers and implications of WLFs in small reservoirs, particularly those fed by intermittent streams, remain poorly understood. Here, we examined the temporal dynamics of WLFs and their relationship with nutrient availability in nine small reservoirs in the U.S. Midwest using daily records from 1985 to 2022. We used water level classification from modified Zscore and transition matrices to assess …

Exploring Racial Identity Among East And Southeast Asian Transracial Adoptees In The United States Through Communication Theory Of Identity, Brooke Marie Hoá Hornberger

Department of Communication Studies: Dissertations, Theses, and Student Research

The purpose of this study was to understand how East and Southeast Asian transracial adoptees (ESATA) in White adoptive families conceptualize and communicate their racial identity. ESATAs endure various challenges surrounding race that makes it important to understand how ESATAs understand their racial identity, the tensions they might experience, and how they management the tensions surrounding racial identity. Using the theoretical framework Communication Theory of Identity (Hecht, 1993), 25 ESATAs were interviewed about different frames of identity and potential identity gaps they experience surrounding racial identity. In addition, ESATAs were asked about how they communicatively manage identity gap tensions mapping …

Aptamer Selection And Development Of Electrochemical Aptamer-Based Sensors For Neuropeptide Y, Evelyn Adela Carreto Guevara

Department of Chemistry: Dissertations, Theses, and Student Research

In this thesis, we report the results of four aptamers obtained from an aptamer selection process called the systematic evolution of ligands by exponential enrichment (SELEX) with affinity to Neuropeptide Y (NPY). NPY is a highly abundant peptide transmitter with widespread distribution throughout the body which affects various physiological functions. These functions include energy homeostasis, appetite regulation, stress response, and anxiety regulation. Dynamic monitoring of NPY levels is crucial for better understanding behaviors in individuals with neurological disorders associated with NPY. Aptamers are synthetic oligonucleotides obtained through SELEX which have a binding affinity to a target of interest when in …

Depuration Of A Solitary Ascidian Depletes Transient Bacteria Without Altering Microbiome Alpha-Diversity, Brenna Hutchings, Susanna López-Legentil, Lauren M. Stefaniak, Marie L. Nydam, Patrick M. Erwin

Marine Science

Depuration, or the process of clearing impurities from the gut, is commonly applied to marine food products due to its efficacy in removing human pathogens from shellfish and edible ascidians. Recent studies also reported that depuration of filter-feeding animals helped reduce transient bacteria and identify resident symbionts in gut microbiome studies. Here, we examined the impact of depuration on bacteria in the branchial sac, gut, and hepatic gland of the solitary ascidian Pyura vittata. Replicates were kept in filtered seawater for 4 days prior to dissection (aquaria-depuration) and compared to samples that were immediately processed following collection (wild-no depuration) and …

Breaking Confirmatory Spells By Implementing Research- Integrated Cures, J. A.C. Vriezen

Biological Sciences: Faculty Publications

Differences in economic and social growth and academic equity, experi ences, and opportunities have left an achievement gap in STEM for underprivileged students. Course-based Undergraduate Research Experiences (CUREs) have attempted to answer these inequalities by leveling the playing field or by offering course-based research opportunities with minimal requirements for background knowledge. When we ask novel questions, more students get the experience of performing research, which lowers thresholds to pursue research and increases participation. Although the learning outcomes have been largely positive, there is a concern that many CUREs are still too scaffolded. In contrast, I propose to develop exploratory, hypothesis-driven …

3,5-Dihydroxy-4-Isopropylstilbene (Tapinarof) Is A Partial Aryl Hydrocarbon Receptor Agonist In Fish, Conner A. Dicks

All Theses

The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is essential in regulating development, immune homeostasis, and drug and xenobiotic metabolism. Activation of the AHR by specific ligands results in its translocation to the nucleus where it induces a myriad of gene products, including cytochrome P450 (CYP) drug metabolizing enzymes (e.g., CYP1A1) and other components of the chemical defensome, as well as inflammatory control. Interestingly, the AHR can bind a wide variety of endogenous and xenobiotic ligands which are able to induce unique downstream effects dependent on cell type, inflammatory context, and ligand stability. The AHR is …

Anxiety During Perimenopause: A Narrative Qualitative Study Of The Women’S Lived Experiences, Kayla Mcelhany

Dissertations and Theses (Open Access)

Abstract

Objectives: Perimenopause has been associated with increased anxiety symptoms. However, data is lacking regarding the experiences of women with perimenopausal anxiety and the contributing factors to worsening anxiety symptoms. We explored the experiences of women with self-reported new onset or worsening of anxiety symptoms during perimenopause to better understand contributing factors.

Study design: Twenty women participated in one-on-one interviews to explore experiences of perimenopausal anxiety in the context of their daily lives and perimenopausal physical changes. Inductive thematic analysis was used to develop codes and themes from the transcribed interview data. Analysis was done using MAXQDA software.

Main …

Association Of Epigenetic Aging With Plasma Cbiomarkers Of Amyloid, Tau, Neurodegeneration, And Neuroinflammation In Hispanic/Latino Adults, Myriam Fornage, Wassim Tarraf, Martha L Daviglus, Charles Decarli, Kevin A Gonzalez, Carmen R Isasi, Sayaka Kuwayama, Melissa Lamar, Bonnie E Levin, Humberto Parada, Alberto R Ramos, Tatjana Rundek, Bharat Thyagarajan, Hector M González

The Brown Foundation: Institute of Molecular Medicine

Background: Blood-based biomarkers hold significant promise for the early detection and diagnosis of Alzheimer's disease (AD) and other dementias. Age-related changes in blood levels of AD biomarkers are well-documented but poorly understood. Epigenetic clocks are mathematical models based on DNA methylation patterns that reflect various aspects of the multidimensional aging process. We investigated the associations of epigenetic aging with five blood-based AD biomarkers in 2656 Hispanic/Latino adults (mean age 62.5 years; 65% females) from the Hispanic Community Health Study/Study of Latinos. We used multivariable linear regression models to estimate the associations of acceleration in each of five epigenetic clocks with …

Local Adaptation In The Pinus Palustris Ground Layer, Jason Paul Joines

All Dissertations

Population survival or extirpation may be dependent on adaptation to local environmental conditions. I hypothesized that populations of species with large ranges would be locally adapted because of the variety of environments that different populations experience, that spatial patterns of local adaptation would correspond to patterns of endemism because processes driving local adaptation may also lead to speciation, and that the extent of local adaptation would be stronger in species with little gene flow among populations than in those with extensive gene flow because of the relative strength of selection necessary to overcome gene flow. I tested these hypotheses using …

Antithrombotic Strategies And Outcomes In Neonates And Infants With Cardiac Shunts: A Systematic Review And Meta-Analysis., Amy L. Kiskaddon, Neil A. Goldenberg, Marisol Betensky, Joshua W. Branstetter, Dina Ashour, Pamela Williams, Arabela C. Stock, Michael Silvey, Therese M. Giglia, Nhue L. Do, Cardiac Disease Thrombosis And Hemostasis Working Party Of The Isth Ssc Subcommittee On Pediatric And Neonatal Thrombosis And Hemostasis

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Cardiac shunt thrombosis in neonates and infants remains a concern for shunt failure and mortality. The optimal strategy for thromboprophylaxis remains unknown.

OBJECTIVES: This systematic review aims to characterize antithrombotic strategies and outcomes in neonates and infants with a cardiac shunt.

METHODS: MEDLINE, Embase, and Cochrane CENTRAL were searched from inception through July 2024 for studies reporting shunt thrombosis prevalence among infants who received a cardiac shunt. We estimated the pooled prevalence of shunt thrombosis using random-effects meta-analysis. In the subgroup analysis, we evaluated the effects of shunt type and antithrombotic strategies on shunt thrombosis prevalence.

RESULTS: A total …

Inhibitor Development And Clinical Characteristics In Children With Severe Hemophilia A In The Athn 8 Us Cohort Study., Courtney D. Thornburg, H Marijke Van Den Berg, Martin Chandler, Lynn Malec, Matthew Manuel, Carrie O'Neill, Michael Recht, Elizabeth Taggart, Shannon L. Carpenter, American Thrombosis And Hemostasis Network (Athn) 8 Investigators Study Group

Manuscripts, Articles, Book Chapters and Other Papers

Clotting factor concentrate (CFC), used to treat and prevent bleeding in hemophilia, is rendered ineffective if clotting factor neutralizing antibodies (inhibitors) develop. Inhibitors occur most often in children, early in treatment. The American Thrombosis and Hemostasis Network (ATHN) 8: US Cohort Study of Previously Untreated Patients (PUPs) with Congenital Hemophilia, conducted in children born in 2010 to 2020 with severe or moderate hemophilia, was designed to determine the percentage of participants who developed a confirmed, clinically significant inhibitor within the first 50 CFC exposure days (EDs). Cox proportional hazards models were used to evaluate risk factors for inhibitor development in …

Expression Of Glycine Transporter 1 In The Rodent Basal Ganglia: Glial Vs. Neuronal, Rosa Atziri Perez

Open Access Theses & Dissertations

Glycine functions as an inhibitory neurotransmitter in the central nervous system (CNS),and it is mainly involved in autonomic functions. The levels of extracellular glycine are regulated by two membrane transporters, glycine transporter 1 and glycine transporter 2 (GlyT1 and GlyT2, respectively). These transporters differ in function and localization within the CNS. For many years, studies suggested that only GlyT2 served as a neuronal marker; however, GlyT1 has been localized in neurons in recent studies. The expression of GlyT1 is widespread compared to GlyT2; hence, the main objective is to determine the nature of the expression of GlyT1 in areas devoid …

Humboldt County, Dennis Robert Sanchez

Open Access Theses & Dissertations

Danny Marquez, a police sergeant for the Los Angeles Police Department, takes his family on a vacation to Seattle, Washington. On the way, they stop in Humboldt County, and Danny is captivated by the beauty and serenity of this county. He imagines moving his family to Humboldt County and leaving the troubles of big city life behind. He applied for the position of Chief Inspector for the Humboldt Police. By the time he is hired, he loses both his son to Fentanyl and his wife to suicide. He is hired for the position but finds himself alone. He considers suicide. …

Identification Of Secondary Metabolites In Ethyl Acetate Extract Of Ki Encok Plant Roots (Plumbago Zeylanica Linn) And In Silico Cytotoxicity Activity, Mitayani Purwoko, Trisnawati Mundijo, Yesi Astri, Siti Rohani

Chimica et Natura Acta

The Ki Encok plant (Plumbago zeylanica Linn) has been extensively studied and is known to have cytotoxic activity. However, no research has yet investigated the compound content of the ethyl acetate extract from that plant. This study aims to identify the secondary metabolite content in the ethyl acetate extract of Plumbago zeylanica L. roots and to determine the potential of these secondary metabolites to bind with the Caspase-3 protein in silico. The ethyl acetate extract of Plumbago zeylanica roots was tested for its phytochemical properties and examined using GC-MS. The compounds found were then searched for their structures in Pubchem, …

Use Of A Preliminary Artificial Intelligence-Based Laryngeal Cancer Screening Framework For Low-Resource Settings: Development And Validation Study, Shao Wei Sean Lam, Min Hun Lee, Michael Dorosan, Samuel Altonji, Hiang Khoon Tan, Walter T. Lee

Research Collection School Of Computing and Information Systems

Background: Early-stage diagnosis of laryngeal cancer significantly improves patient survival and quality of life. However, the scarcity of specialists in low-resource settings hinders the timely review of flexible nasopharyngoscopy (FNS) videos, which are essential for accurate triage of at-risk patients.Objective: We introduce a preliminary AI-based screening framework to address this challenge for the triaging of at-risk patients in low-resource settings. This formative research addresses multiple challenges common in high-dimensional FNS videos: (1) selecting clear, informative images; (2) deriving regions within frames that show an anatomical landmark of interest; and (3) classifying patients into referral grades based on the FNS video …

B.R. Wells Arkansas Rice Research Studies 2024, J. Hardke, X. Sha, N. Bateman

Arkansas Agricultural Experiment Station Research Series

Research reports contained in the publication may represent preliminary or only a single year of results; therefore, these results should not be read as a basis for long-term recommendations.

Several research reports in this publication will appear in other University of Arkansas System Division of Agriculture’s Arkansas Agricultural Experiment Station publications. This duplication is the result of the overlap in research coverage between disciplines and our effort to inform Arkansas rice producers of all the research being conducted with funds from the rice check-off program. This publication also contains research funded by industry, federal, and state agencies.

Use of products …

Concordia Seminary Magazine Summer 2025, Vicki Biggs

Concordia Seminary Magazine

Bearing Witness to the Truth

Experimental Evaluation And Comparison Of Football-Related Head Impacts Among Ovine, Human, And Hybrid Iii Headforms, Madysn D. Cardinal

All Dissertations

Concussions and traumatic brain injury (TBI) remains a significant public health concern, especially in American football, where repeated head impacts pose long-term risks to athlete health. While current helmet testing standards rely heavily on the Hybrid III surrogate headform to evaluate protective performance, these surrogate models lack anatomical accuracy and exclude the presence of a brain component, limiting their ability to capture the true mechanics of concussion. To address this limitation, this research developed and validated a novel inverted impact testing method that allows the impact testing of a Hybrid III headform and a cadaveric specimen. Additionally, this fixture preserves …

Elucidating The Mechanisms Underlying A Functional Plant-Arbuscular Mycorrhizal Symbiosis Using Omics Approaches, Jasmine Gill

All Dissertations

Arbuscular mycorrhizal fungi (AMF) are obligate biotrophs forming symbiotic association with plants. The plant-AMF symbiosis has gained much attention due to its ability to improve plant nutrient uptake, especially phosphorus, which is often inadequately available to plants due to its limited mobility and complex formation in many soils. Phosphorus (P) is a crucial nutrient for plants, and most phosphate fertilizers are derived from phosphate rock, a finite natural resource. Thus, optimizing P uptake is vital for sustaining crop yields and addressing the needs of a growing global population. Plant-AMF symbioses are significant in this context, as AMF can acquire P …

Alternative Therapeutics For Human Breast Cancer: Nutraceutical Underpinnings, In Vitro Metabolomic Profiling, Treatment Efficacy, And Contextual Ethical Implications, Aubrey A. Mattingly

All Dissertations

Breast cancer remains one of the most prevalent diseases worldwide, yet therapeutic equity is still lacking. Standard treatments including surgery, radiotherapy, chemotherapy, and long-term hormone therapy. These approaches are often accompanied by significant side effects. While newer methods such as immunotherapy and targeted therapies have emerged, chemotherapy protocols and incorporation have remained largely unchanged in the past decades. In this context, nutraceuticals represent an alternative or adjuvant to therapy worthy of exploration. The reviewed literature highlights the anti-carcinogenic activity in selected nutraceuticals, marjoram, thyme and persimmon, considering their phytochemical constituents and secondary metabolites. Metabolomic profiling using the Biolog Phenotype Mammalian …

Population Analysis Of Cyanobacteria In Rotating Algal Biofilm Reactors, Eric H. Matthews

All Graduate Theses and Dissertations, Fall 2023 to Present

Algal biofilms have numerous applications in wastewater treatment and bioproduct production. The Sustainable Waste-to-Bioproducts Engineering Center at Utah State University is working to develop rotating algal biofilm reactors (RABRs) to remove excess nitrogen and phosphorus from wastewater effluent while producing biomass for downstream production.

Genetic analysis of algal biofilms on various RABRs was performed to gain improved understanding of the biofilm populations. This analysis focuses on a pilot-scale RABR and how it compares to several other RABRs. Additionally, old methods of genetic analysis filtered out important cyanobacterial populations. A new method was developed to identify the cyanobacteria within the biofilms. …

Soil Health On Utah's Farms And Ranches, Jenae Dean

All Graduate Theses and Dissertations, Fall 2023 to Present

The term soil health has gained popularity in agriculture due to prolonged droughts, rising food costs, and the growing public concern for sustainable and organic practices. Soil health practices can offer solutions to all of these pressures. This thesis provides Utah's farmers and ranchers with quantifiable data on implementing soil health practices in Utah's unique climate. It presents the first two years of on-farm trial results on yield and quality after implementing various soil health practices on five categories of crops: corn, mixed hay, alfalfa, produce, and dryland grain. Over a two-year period, none of the soil health practices resulted …

Unveiling Insights From Complexity: Advanced Computational Techniques For High-Dimensional Medical Data, Devin P. Eddington

All Graduate Theses and Dissertations, Fall 2023 to Present

Healthcare generates vast amounts of data daily, from genetic profiles to hospital records, but much of it remains untapped due to its complexity. This dissertation develops new computational tools to unlock this data’s potential, aiming to improve patient care and medical research. Five projects tackle different challenges: Project 1 creates Deep MAGIC, a method to fill in missing genetic and image data accurately, vital for understanding diseases like cancer. Project 2 analyzes how the COVID-19 pandemic disrupted surgeries, finding a 27% drop and temporary complication rises in 2020, guiding future crisis planning. Projects 3 and 4 study kidney disease trials, …

Soil Carbon Storage And Its Relation To Abiotic And Biotic Factors In The Boise Foothills, Richie William Holder

Boise State University Theses and Dissertations

Terrestrial soil sequesters a significant amount of carbon (C), and changes to this pool can impact atmospheric CO2 concentrations and climate change. Thus, it is crucial to understand the drivers of the size of this pool. Changes in plant community composition in semi-arid ecosystems can impact soil C storage. However, little is known about the impact of plant functional type on the quantity and distribution of soil C on a landscape scale relevant to ecosystem management. I conducted a study in the City of Boise’s Open Space Reserves located north of Boise, Idaho to evaluate how plant functional type affects …