Digital Commons Network^™

Mechanisms Of Gold Enrichment In Seafloor Massive Sulfide Deposits: A Study On The Higashi-Aogashima Hydrothermal Field, Claudia Martinez

UNLV Theses, Dissertations, Professional Papers, and Capstones

The study of Seafloor Massive Sulfides (SMS) deposit formation is vital for assessing both the economic potential and environmental risks posed by future marine mining projects. Metal-rich SMS deposits form in hydrothermal vent systems within tectonically active regions, such as back-arc basins, where faults enhance crustal permeability, enabling fluid migration driven by magmatic heat sources at depth in the crust. Currently our understanding of SMS formation processes is based on bulk-rock geochemical and isotopic data, lacking the necessary spatial and temporal resolution to understand ore forming processes. As a result, critical gaps remain in understanding the exact mechanisms responsible for …

Ecological Momentary Assessment Of Mood, Affect, And Perceived Criticism: Investigation Of Daily Patterns And Family Impact, Kayla Mcginty

UNLV Theses, Dissertations, Professional Papers, and Capstones

Perceived criticism (PC) is a component of expressed emotion (EE) that assesses an individual’s perceptions of the criticism that they are exposed to within their interpersonal relationships. PC is elevated among individuals with mood disorders, and mood and mood symptoms act as both a predictor and an outcome of PC. However, few studies have examined the relationship between PC and affect, a more momentary measure of emotion that can serve as a guide to underlying mood. Additionally, limited research has examined how PC within family relationships compares to other interpersonal interactions. Understanding the relationship between momentary affect and PC and …

Bio-Inspired Electroactive Polymer (Eap) Sensors For Surface And Canal Flow Sensing In Dynamic Environments, Nazanin Minaian

UNLV Theses, Dissertations, Professional Papers, and Capstones

Nature can often create some of the most efficient and elegant solutions to complex problems, and engineering stands to benefit greatly from these time-tested designs. One of the more sophisticated examples of this is the lateral line system in fish: a distributed network of superficial and canal neuromasts that enables aquatic species to detect fluid disturbances with remarkable precision. This dissertation leverages that biological framework to explore the potential of electroactive polymers (EAPs), aiming not just to replicate structure, but to emulate function.Two classes of EAPs form the basis of this work: electroactive plasticized polymer gels (EPPGs) and ionic polymer-metal …

Identifying Appropriate Clinical Cutoffs For Traumatic Dissociation In Maltreated Youth, Amanda L. Mraz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Maltreated youth who experience traumatic dissociation are at an increased risk for various severe psychopathological outcomes. Much is still unknown about the risk factors for traumatic dissociation in maltreated youth. The present study aimed to identify dissociation (e.g., dissociative amnesia, absorption and imaginative involvement, passive influence, and depersonalization and derealization) risk factors, via parametric statistical methods, in association with the appropriate clinical cutoff for the total and subscale scores from the Adolescent Dissociative Experiences Scale (A-DES). Investigatory variables included demographic (e.g., age, race, and gender), cognitive (e.g., resiliency and posttraumatic cognitions), and psychological (e.g., posttraumatic stress disorder, anxiety, and depression …

Investigating Information Extraction And Language Models In Medical Domain Text Processing, Pouyan Nahed

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation demonstrates that carefully adapted language-model pipelines can transform unstructured clinical-trial and pharmacological prose into reliable, low-latency structured data. Four interconnected studies support this claim.Tri-AL platform. An open-source dashboard ingests all 440 k+ ClinicalTrials.gov records—including every historical revision—into a normalized schema and parses the 20 GB XML archive over 10x faster than a BeautifulSoup baseline, while exposing hooks for demographic analytics and supporting integration of user-defined modules. Clinical trial summarization. An encoder–decoder model is trained on 57k description–summary pairs to condense clinical trials into a few sentences. ROUGE evaluation shows a 20% improvement over the baseline, while graph-based evaluation …

School Absenteeism In Children With Disabilities: An Analysis Of School Climate And Academic Mindset, Karolyne Bastos Stucki

UNLV Theses, Dissertations, Professional Papers, and Capstones

Students with disabilities (SWDs) are more likely to be chronically absent than general education peers (Anderson, 2021; Gee, 2018, U.S. Department of Education, 2016). Etiology for SWDs is complex with influencing factors spanning multiple ecological levels, but bolstering protective factors for SWDs may address attendance disparities. Multi-tiered systems of support (MTSS) models have the potential to address absenteeism in SWDs via school-wide preventative and/or intervention efforts (Tier 1 & 2) aimed at increasing or decreasing influencing factors in students with disabilities. School climate and academic mindset may influence students with disabilities’ attendance. The purpose of the present study was to …

An Analysis Of The Influence Of Human Disease Pathogens On Core Behaviors Of The Black-Legged Tick, Emily F. Marinko

UNLV Theses, Dissertations, Professional Papers, and Capstones

Ixodes scapularis, the black-legged or deer tick, is a vector for several different disease-causing microbes, including the causative agent of Lyme disease. As such, it is a major health concern for people living within its range in the eastern half of the United States, a habitation area that is increasing due to climate change. Despite its medical relevance as a disease vector, there is still much to learn about the basic behavior of these arachnids in the wild. Thus, the major hypothesis of this thesis is that ticks that are infected with specific human disease-causing microbes behave differently than those …

Kinase Suppressor Of Ras 2 Regulates Energy Balance And Tumor Initiation, Dianna H. Huisman

Theses & Dissertations

Kinase Suppressor of Ras 2 (KSR2) is a scaffold that facilitates Raf-MEK-ERK signaling and is expressed in the brain, pituitary, and adrenal gland. Here, we demonstrate that KSR2 functions in the adult brain to maintain organismal energy balance and in small-cell lung carcinoma (SCLC) to promote self-renewal and clonogenicity. Disruption of KSR2 in adult mice results in hyperphagia, obesity, reduced metabolic rate, and altered activity. Using spatial transcriptomics, we identify regions of the brain associated with regulation of feeding and energy expenditure with altered gene expression following KSR2 disruption. These findings reveal regions of interest in which targeted KSR2 disruption …

Claudin-1-Mediated Signaling And Therapy Resistance In Colorectal Cancer: From Mechanism To Translation, Mark W. Primeaux

Theses & Dissertations

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, with metastatic cases showing poor response to chemotherapy due to both intrinsic and acquired therapy resistance. Claudin-1 (CLDN1), a tight junction protein, is overexpressed and mislocalized outside of tight junctions in CRC, where it contributes to an aggressive, metastatic phenotype. Although this causal relationship has been well established, the mechanisms by which CLDN1 promotes tumor progression were unclear due to its lack of intrinsic enzymatic activity. This dissertation investigates the molecular mechanisms through which CLDN1 drives oncogenic signaling, its role in therapy resistance, and its translational potential as both a …

Restoring Translational Control With Novel Small Molecule Activators Of Pp2a In Cancer Cells, Kayla A. Jonas

Theses & Dissertations

Hyperactivation of eIF4E-dependent translation in tumor cells is required for robust expression of oncogenic proteins and maintenance of the transformed phenotype. eIF4E binds to the 7-methylguanylate structure at the 5’ end of cellular mRNAs and nucleates the formation of the translation initiation complex, eIF4F, which recruits the preinitiation complex and resolves secondary structure in the mRNA. The ability of eIF4E to promote eIF4F assembly is negatively regulated by the translational repressor, 4E-BP1, and tumorigenesis depends on functional inactivation of 4E-BP1. A major mechanism of 4E-BP1 inactivation involves inhibitory phosphorylation by mTOR which prevents eIF4E binding. Functional inactivation can also occur …

Scientist Perspectives: A Correlation Analysis Of Translational Science Competencies Compared With Principles Of Engagement And Knowledge Integration, Rachel Wenzl

Theses & Dissertations

The competencies identified in the development of the “Fundamental Characteristics of the Translational Scientist” may not consider and fully integrate the concepts of knowledge integration and engagement, key components of the translational science spectrum. This gap may be widening and deepening the “valley of death” and exacerbating ongoing challenges in the field of translational science. This dissertation explored the association of knowledge integration, stakeholder engagement, and community engagement principles compared with translational science competencies.

Utilizing content review and a non-experimental, correlation study design, data were collected through a quantitative survey from adult research subjects all self-identified as a research investigator …

Transcriptomic And Epigenomic Profiling Of Immune Cells Responses To Simian Immunodeficiency Virus Infection In The Brain, Xiaoke Xu

Theses & Dissertations

Human immunodeficiency virus type 1 (HIV-1) is an enveloped retrovirus that significantly impairs the human immune system. A common complication of HIV-1 infection is HIV-associated neurocognitive disorder (HAND), which, prior to the introduction of antiretroviral therapy (ART), led to considerable morbidity and mortality due to untreated neuropsychiatric manifestations. Although ART has substantially reduced the incidence of HIV-associated dementia (HAD), approximately 50% of people living with HIV (PLWH) continue to experience milder forms of HAND. The CNS is seeded by HIV during the acute phase of infection. Once in the brain, HIV targets and activates resident immune cells, primarily microglia and …

Temporal Patterns Of Ectopic Pregnancy: Using The Electronic Health Record To Illuminate A Dark Corner In Women's Health, Kirsten Hepburn

Theses & Dissertations

Ectopic pregnancy remains a significant contributor to pregnancy-related morbidity and mortality, yet little is known about whether its occurrence follows discernible temporal patters that could inform prediction and prevention efforts. This dissertation aimed to explore the temporal characteristics of ectopic pregnancy through three interrelated projects: development of a new theoretical framework, a scoping review of the literature on ectopic pregnancy temporal patterns, and an empirical study using electronic health records data from a ten-year period at a single academic medical center. The Nursing Genomic and epigenomic, Environment, and Microbiome (N-GEM) situation-specific theoretical framework was introduced as a novel nursing theory …

Role Of Stabilin-1 Expressing Macrophages In Colorectal Liver Metastasis, Jampa L. Gurung

Theses & Dissertations

Colorectal cancer (CRC) is the 2nd most common cause of cancer-related mortality, primarily due to its spread to distant organs. Colorectal liver metastasis (CRLM) is the foremost form of CRC spread due to the anatomical link between the liver and intestine. Despite advancements in diagnostic tools and adjuvant therapies, the survival rate of CRLM remains low, indicating the significant need to identify targetable mechanisms. Stabilin-1 (STAB1), a scavenger receptor expressed on tumor-associated macrophages, has been linked to tumorigenesis and poor outcomes in various cancers. However, the role of STAB1 in CRLM is not known. Here, we investigated the role of …

A Comparative Subnational Policy Analysis Of State Covid-19 Vaccine Policies And Application Of The Political Determinants Of Health Model, Demetrius Cianci Chapman

Nursing ETDs

A COMPARATIVE SUBNATIONAL POLICY ANALYSIS OF STATE COVID-19 VACCINE POLICIES AND APPLICATION OF THE POLITICAL DETERMINANTS OF HEALTH MODEL

By

Demetrius Cianci Chapman

Associate of Science Nursing, Jewish Hospital College of Nursing and Allied Health, 1998

Bachelor of Science of Nursing, Saint Louis University, 2000

Master of Public Health, Saint Louis University, 2004

Master of Science Nursing (Research), Saint Louis University, 2004

Doctor of Philosophy, Nursing, University of New Mexico, 2025

ABSTRACT

This study uses the political determinants of health (PDoH) framework to analyze state-level COVID-19 vaccine policies and their impact on population health. The PDoH model examines how structured …

Flowing Progress: Transforming The Danube Through Infrastructure, Stefan Dorondel, Luminita Gatejel

Central European Studies

Flowing Progress: Transforming the Danube Through Infrastructure focuses on how different political regimes and forms of governance have imagined and technologically transformed the most international river in the world. Multidisciplinary and drawing on methodologies of history, anthropology of infrastructure, and science, technology, and society, this collection explores the tensions between the river and its natural pulses, the humans that populate its floodplains, state agencies, and infrastructure. The book engages the concept of disturbance to point out the circular and spiraling dynamics between hydrological processes and technopolitical and economic practices. Disturbance denotes a specific type of long-term dynamic between human attempts …

Empowering Science With The World's First High Accuracy And High Throughput Functional Assay, Christopher Giacoletto

UNLV Theses, Dissertations, Professional Papers, and Capstones

Understanding the functional consequences of genetic mutations remains a central challenge in modern biology, with far-reaching implications for human health and disease. While early systematic methods like alanine scanning and phage display provided foundational insights into protein structure and function, the emergence of high-throughput approaches—such as Multiplexed Assays of Variant Effect (MAVEs)—and predictive tools powered by artificial intelligence have vastly expanded our ability to profile mutational landscapes. However, these methods are often constrained by trade-offs between accuracy, scalability, and biological relevance.This dissertation presents the development and application of the GigaAssay, the world’s first high-throughput functional assay capable of delivering both …

The Dropbot: Design And Development Of A Custom Drone For Precision Water Drop Penetration Time (Wdpt) Testing, Mugundan Prakash

UNLV Theses, Dissertations, Professional Papers, and Capstones

Assessing the hydrophobic characteristics of soil is vital for understanding soil wettability or soil-water interactions, particularly in post-wildfire environments where water repellency can significantly impact ecosystem recovery, water infiltration, and erosion control. One key metric in soil wettability studies is the Water Drop Penetration Time (WDPT) test, which evaluates the hydrophobicity of soil and guides land treatment strategies. This thesis presents the design and development of DropBot, a custom-built drone platform engineered for the precise delivery and analysis of water droplets in WDPT tests.The DropBot, a custom drone, integrates a lightweight, 3D-printed frame with a self-leveling platform, enabling consistent droplet …

Professional Portfolio, Grace E. Lowder

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Ability Of Staphylococcus Epidermidis And Escherichia Coli To Eliminate Cadmium, Lead And Copper From Tigris River In Mosul City, May A. Abdul Kader, Ghada A. Mohammad

Baghdad Science Journal

The heavy metals are non-biodegradable and could be toxic and carcinogenic, thus, their improper concentration in water could result in critical health issues for living organisms. Therefore, this study aimed to remove three heavy metals (Cadmium, lead and copper) by biological treatment especially using environmental nonpathogenic bacteria such as Staphylococcus epidermidis and Escherichia coli. Eight samples were collected from Tigris River from different regions of Mosul city. Two containers were used for each sample to measure the concentration of minerals before and after treatment by bacteria. The results showed that E. coli was more efficient in removing two heavy …

Nitrogen Fertilizer Equivalence Of Red Clover When Inter-Seeded Into Corn, Hannah R. Francis, Ting Fung Ma, Rodrigo Werle, Chelsea H. Zegler, Daniel H. Smith, Douglas J. Soldat, Erika Marin-Spiotta, Matthew D. Ruark

Faculty Publications

Inter-seeding red clover (Trifolium pratense L.) provides an alternative method toincorporate cover crops into continuous corn (Zea mays L.) in the Upper US Midwest. Red clover is a leguminous cover crop that can grow in low-radiation environments and is winter hardy. Systems with red clover have demonstrated improved corn yield and a fertilizer N equivalence but understanding these effects with inter-seeding war-rants further investigation. The objectives of this study were to determine the effect of inter-seeding red clover on (i) plant-available N during and after red clover decomposition, (ii) optimum N rates for corn, and (iii) corn yields. The …

Nitrogen Fertilizer Equivalence Of Red Clover When Inter-Seeded Into Corn, Hannah R. Francis, Ting Fung Ma, Rodrigo Werle, Chelsea H. Zegler, Daniel H. Smith, Douglas J. Soldat, Erika Marin-Spiotta, Matthew D. Ruark

Faculty Publications

Inter-seeding red clover (Trifolium pratense L.) provides an alternative method to incorporate cover crops into continuous corn (Zea mays L.) in the Upper US Midwest. Red clover is a leguminous cover crop that can grow in low-radiation environments and is winter hardy. Systems with red clover have demonstrated improved corn yield and a fertilizer N equivalence but understanding these effects with inter-seeding warrants further investigation. The objectives of this study were to determine the effect of inter-seeding red clover on (i) plant-available N during and after red clover decomposition, (ii) optimum N rates for corn, and (iii) corn …

Master Of Social Work Portfolio, Julia Volner

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Msw Portfolio, Julia Marie Sweeney

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio reflects my personal and professional growth throughout the University of Montana’s MSW program. Grounded in lived experience, child advocacy work, and academic learning, it highlights my development across core competencies and advanced integrated practice.

Becoming A Social Justice Worker, Laura Curry

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

The Association Of Walking Cadence With Sleep Quality In Adults 18-65, Almothana M. Matarneh

Masters Theses, 2020-current

Sleep quality is essential to physical and mental health, influencing physiological functions including muscle recovery, hormonal balance, immune response, and cognition. Poor sleep may impact physical activity (PA) and sedentary behavior (SB), potentially contributing to reduced overall well-being. Walking cadence, the number of steps per minute, is an accessible proxy for PA intensity, but its relationship with sleep quality remains unclear. Objective: This study examined the relationship between PA, SB, and sleep quality, as measured by step cadence, among adults aged 18–65 years. Methods: participants wore an ActiGraph GT3X accelerometer on the hip during waking hours and on …

Analysis Of Leak Testing Planning For Carbon Dioxide Piping Systems In The Development Of Carbon Capture, Utilization, And Storage Facilities In The Bintuni Basin, Devi Sentiani, Akhmad Herman Yuwono Professor

Journal of Materials Exploration and Findings

Carbon Capture, Utilization, and Storage (CCUS) technologies have become a key strategic response to global efforts to reduce CO₂ emissions. This study presents a leak testing strategy designed for a carbon dioxide (CO₂) piping system as part of a Carbon Capture, Utilization, and Storage (CCUS) project in the Bintuni Basin, West Papua, Indonesia. This study aims to ensure the system is properly prepared before commissioning by designing a leak test plan that is both practical and technical, based on ASME B31.3, ASME PCC-2, and API STD 520 Part 1. We conducted the process, which involves identifying the system boundaries, …

Chromatographic Developments For The Analysis Of Toxic Organic Chemicals In The Environment And Food Samples, Stephanie Devi Nauth

Graduate Thesis and Dissertation post-2024

As awareness grows about compounds harmful to human health, the need for sensitive detection methods at low concentration levels becomes increasingly critical. Chromatography is a powerful analytical technique that enables the separation of complex mixtures, allowing for the simultaneous analysis of multiple analytes—even at trace levels. This dissertation applies chromatography in two distinct contexts: (1) Investigating the sorption of polycyclic aromatic sulfur heterocycles (PASHs) onto nylon microplastics; and (2) Detecting illegal dyes in various food matrices.

Microplastics have emerged as significant vectors for transporting pollutants into aquatic ecosystems. Due to their hydrophobic nature, many organic pollutants readily sorb onto microplastics …

Advancing Ground-Based Instrumentation With Astrophotonics For Stellar Astrophysics And Time-Domain Spectroscopy, Christina D. Moraitis

Graduate Thesis and Dissertation post-2024

This dissertation presents advancements in Astrophotonics with a focus on PolyOculus technology - a novel, scalable approach to astronomical instrumentation designed to enhance observational capabilities in a cost-effective manner. It details the development of the Original PolyOculus Array (OPA), its integrated light-combining device (the photonic lantern), and its dedicated spectrograph, OPASpec. In parallel, the final commissioning of the MIRADAS Near-Infrared spectrograph is described. These instrumental innovations are applied to key astrophysical investigations, including the search for coronal mass ejections on M-dwarfs and time-resolved spectroscopic monitoring of T Coronae Borealis during its pre-eruption phase. By combining cutting-edge instrument design with cross-institutional …

Preparing For The Habitable Worlds Observatory: Spectropolarimetric Radiative Transfer Models Of Terrestrial (Exo)Planets, Kenneth E. Goodis Gordon

Graduate Thesis and Dissertation post-2024

The next major step for the exoplanet community lies in the characterization of terrestrial exoplanets, especially when it comes to identifying biosignatures and determining the habitability of these worlds. In response to this, NASA has proposed the Habitable Worlds Observatory (HWO), with the primary goal of searching for and characterizing Earth-sized planets in the habitable zones (HZ) of their stars. However, current characterization strategies that only rely on the unpolarized flux from the planets lose some of the informational content of the observed light and therefore suffer from degeneracies in the calculated planetary parameters. The sensitivity of polarization to the …