Digital Commons Network^™

Screening And Characterization Of Yeast Strains From Naturally Fermented Rosa Roxburghii Pomace, Yong Li, Fang Yuan, Yu Fu, Luo Peng

Journal of Food Science and Biotechnology

[Objective ] This study aimed to develop high-quality fermented Rosa roxburghii (R.roxburghii ) products by screening yeast strains suitable for R.roxburghii fermentation.[Method ] The naturally fermented R.roxburghi pomace was used as the material for preliminary screening through the TTC colorimetric method and secondary screening based on fermentation capacity.The tolerance of strains to SO 2,ethanol,low pH,and glucose was examined.The strains were identified via morphological characterization and molecular biological techniques.[Result ] Three high-performing strains (B17,B19,and B29) were obtained.These strains exhibited tolerance to 250 mg/L SO 2,mass fraction 60% glucose,volume fraction 8% ethanol,and pH 3.5 environment.B17 and B 29 were identified as Pichia …

Isolation , Identification , And Whole Genome Sequencing Of Lactic Acid Bacteria From Pit Mud Of Jiangxiangxing Baijiu, Heou Huang, Cheng Wu, Shaojuan Yang, Dan Xie, Wenyu Zhao, Junlin Yang, Jianfeng Hu, Feng Hu, Diqiang Wang

Journal of Food Science and Biotechnology

[Objective ] This study aims to develop functional microbial strain resources from the pit mud of Jiangxiangxing Baijiu and explore their potential in optimizing the fermentation process and improving Baijiu quality.[Method ] Lactic acid bacteria were screened from the pit mud of Jiangxiangxing Baijiu by the spread plate method and then identified by morphological and molecular biological methods.The metabolites of the strains were detected by high performance liquid chromatography and gas chromatography,and the whole genomes of the strains were sequenced via the Illumina sequencing technology.[Result ] Eleven strains of lactic acid bacteria were isolated and screened from the pit mud …

Co-Expression And Application Of Enzymes For Preparation Of Β-Nicotinamide Mononucleotide, Jiehu Liu, Lingqia Su, Huixian Fu, Jing Wu

Journal of Food Science and Biotechnology

[Objective ] This study aims to reduce the cost and simplify the production process of β-nicotinamide mononucleotide (β-NMN ) by the enzyme catalytic method.[Method ] On the basis of the previously established β-NMN synthesis system with six enzymes,the six enzyme genes were combined in pairs to construct double-enzyme co-expression recombinant strains.Each crude enzyme solution obtained by co-expression was used for multi-enzyme catalytic cascade reaction to synthesize β-NMN.[Result ] The yield of β-NMN was as high as 72.90% when the concentration of the substrate D-ribose was 10 mmol/L.The optimal temperature and IPTG induction concentration for inducing the enzyme expression of the …

Imsa Summer Symposium 2025, Student Inquiry And Research (Sir)

Summer Symposium

For nearly four decades, IMSA has worked to advance the human condition through educational innovation. The Summer Symposium is our annual showcase for the research projects that were conducted in IMSA’s experiential learning programs between May and August. These programs include Student Inquiry and Research (SIR), IN2 Business Internships, and the Student Research and Experiential Learning Opportunity (SRELO) program.

Cover Design

Luke Berryman

Exploring The Positive Mental Health Effects Of Participation In College Athletics, Erin J. Harvey, Devin B. Hefner, Lily C. Pysher, Blake A. Green

Graduate Student Scholarship

Abstract

Exploring the Positive Mental Health Effects of Participation in College Athletics

College students participate in sports for positive physical effects, but does this participation increase the students’ mental health positively, too? This research paper seeks to answer this question to determine how occupational therapists and other professionals working with the population of collegiate athletes can have the best outcomes for their clients. While many studies have been conducted to show how sports participation leads to benefits of individuals’ physical health, few studies have been conducted to determine if participation in sports at the collegiate level benefits students’ mental health …

August 15, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Diverse Cell Types Establish A Pathogenic Immune Environment In Peripheral Neuropathy, Julie Choi

Arts & Sciences Graduate Student Theses and Dissertations

Neuroinflammation plays a complex and context-dependent role in many neurodegenerative diseases. We identified a key pathogenic function of macrophages in a mouse model of a rare human congenital neuropathy in which SARM1, the central executioner of axon degeneration, is activated by hypomorphic mutations in the axon survival factor NMNAT2. Macrophage depletion blocked and reversed neuropathic phenotypes in this sarmopathy model, revealing SARM1-dependent neuroimmune mechanisms as key drivers of disease pathogenesis. In this study, we investigated the impact of chronic subacute SARM1 activation on the peripheral nerve milieu using single cell/nucleus RNA-sequencing (sc/snRNA-seq). Our analyses reveal an expansion of immune cells …

Summer Symposium 2025, Student Inquiry And Research (Sir)

IMSAloquium Event Booklets

For nearly four decades, IMSA has worked to advance the human condition through educational innovation. The Summer Symposium is our annual showcase for the research projects that were conducted in IMSA’s experiential learning programs between May and August. These programs include Student Inquiry and Research (SIR), IN2 Business Internships, and the Student Research and Experiential Learning Opportunity (SRELO) program.

Structure And Function Of Type 1 Pilus Assembly Machinery In Uropathogenic Escherichia Coli, Ryan Bitter

Arts & Sciences Graduate Student Theses and Dissertations

Gram-negative bacteria produce chaperone-usher pathway (CUP) pili, which are extracellular adhesive protein fibers critical for host-pathogen interactions. An outer-membrane usher protein, together with a periplasmic chaperone, assembles thousands of pilin subunits into a pilus fiber. Each pilus is tipped by an adhesin that mediates host and tissue tropisms by binding to receptors with stereochemical specificity. Type 1 pili expressed by uropathogenic Escherichia coli (UPEC) are essential virulence factors in urinary tract infections (UTIs) and facilitate attachment to mannosylated glycoproteins on bladder epithelial cells. Although type 1 pili have been extensively studied, critical gaps remain in our understanding of the molecular …

Evaluation Of Rheumatic Etiologies Underlying Childhood-Onset Arthritis, Seher Şener, Erdal Atalay, Ezgi̇ Deni̇z Batu, Cansu Ayten Tatar, Özge Başaran, Yelda Bi̇lgi̇ner, Seza Özen

Turkish Journal of Medical Sciences

Background/aim: Childhood-onset arthritis may result from various rheumatic diseases. This study aimed to systematically evaluate their distribution and characteristics in a large pediatric cohort.

Materials and methods: We retrospectively analyzed all pediatric patients who presented with arthritis to the pediatric rheumatology clinic between January 2000 and January 2023.

Results: A total of 1713 pediatric patients who presented with arthritis were included in this study (median age at diagnosis: 6.8 years; F/M = 1.2). Most of the patients (n = 859, 50.1%) had juvenile idiopathic arthritis (JIA) (especially oligoarticular JIA). Patients with familial Mediterranean fever, comprising 277 individuals (16.2%) presented with …

Evaluation Of Metabolic Uptake In Gynecological Organs Using Fdg-Pet In Women Diagnosed With Non-Gynecological Malignancies, Funda Atalay, Uğurcan Zorlu, Koray Aslan, Fatma Batak, Tuba Zengi̇n Aksel, Güli̇n Uçmak

Turkish Journal of Medical Sciences

Background/aim: Gynecological malignancies, including those affecting the uterus, cervix, vagina, vulva, and adnexa, pose significant physical and psychosocial burdens. Early detection and effective management of these malignancies are critical for improving outcomes. This study aims to evaluate metabolic uptake patterns in gynecological organs using fluorodeoxyglucose positron emission tomography (FDG-PET) and to analyze their malignancy potential in women with nongynecological cancers.

Materials and methods: A retrospective analysis was conducted on 221 women with nongynecological malignancies who exhibited pathological FDG uptake in gynecological organs on FDG-PET/CT imaging. Lesions were evaluated based on the standardized uptake value maximum (SUVmax), morphological characteristics on contrast-enhanced …

Ultrasonographic And Elastographic Evaluation Of Plantar Fascia And Achilles Tendon Alterations In Type 2 Diabetes Mellitus, Rifat Bozkuş, İhsani̇ye Süer Doğan, Berna Turhan, Sümeyya Duran Kaymak, Mustafa Hulusi̇ Kurt, Rasi̇me Peli̇n Kavak

Turkish Journal of Medical Sciences

Background/aim: The primary aim of this study is to compare the thickness and stiffness of the PF and AT between healthy volunteers and patients with type 2 diabetes mellitus (T2DM). A secondary objective is to explore the correlations between the thickness and stiffness of the PF and AT with diabetes duration (in months) and hemoglobin A1c (HbA1c) levels in T2DM patients without peripheral neuropathy or foot ulcers, with peripheral neuropathy or with foot ulcers.Material and Methods: A total of 289 participants, including 117 healthy volunteers (Group A) and 172 T2DM patients (59.5%), matched for age, sex, and body mass index, …

Detection And Quantification Of Microplastics In Cerumen, Bengi̇ Arslan, Yüce İslamoğlu, Ali̇ Sami̇ Berçi̇n, Selen Akbulut, Mehmet Meli̇koğlu

Turkish Journal of Medical Sciences

Background/aim: Microplastics (MPs) are a growing concern due to their pervasive environmental presence and potential environmental and human exposure impacts. Given evidence of systemic MP presence in human tissues and fluids, and the ear canal's environmental exposure, this novel study aimed to identify these particles in human cerumen. Cerumen was collected from the proximal ear canal to minimize potential airborne contamination.

Materials and methods: Cerumen samples were prospectively collected from 12 adult patients (23 patient-derived specimens) and 3 control water samples, following ethical approval and consent. Samples were extracted using sterile instruments, stored in glass, diluted, and filtered through 0.22 …

Are Paraplegic Wheelchair Users Vulnerable To Overuse Syndromes?, Kutay Tezel, Esra Ülgen Kiratlioğlu, Hüseyi̇n Kayadi̇bi̇, İlkay Karabay, Mi̇tat Cebeci̇, Eda Gürçay

Turkish Journal of Medical Sciences

Background and Aims: The purposes of this study are to determine the frequency of upper extremity overuse syndromes in patients with spinal cord injury (SCI) using manual wheelchairs, to evaluate them clinically and sonographically, and to reveal possible factors that predispose to overuse syndromes.

Materials and methods: A total of 38 traumatic SCI patients who were over 18 years of age and manual wheelchair users were enrolled in this cross-sectional study. The patients were evaluated with clinical and sonographic findings of the wrist, elbow and shoulder joints. Functional capacity, physical ability and symptoms of upper extremity, and quality of …

Prognostic Role Of Systemic Immune-Inflammation Index And Pan-Immune-Inflammation Value In Acute Methanol Poisoning, Hati̇ce Şahi̇n, Gülay Ulusal Okyay, Fatma Ayerden Ebi̇nç, Fevzi̇ Coşkun Sökmen, Emre Yaşar, Gülşen Akçay, Mehmet Deni̇z Ayli

Turkish Journal of Medical Sciences

Background/aim: Acute methanol poisoning (MP) poses a significant public health challenge, with inflammation increasingly recognized as a key factor in its pathophysiology. Identifying accessible and reliable prognostic biomarkers could help enhance clinical outcomes. This study aimed to assess the prognostic value of the Systemic Immune-Inflammation Index (SII) and the Pan-Immune-Inflammation Value (PIV), measured upon emergency department admission, in predicting in-hospital mortality in patients with acute MP.Material and methods: This retrospective study included patients diagnosed with acute MP at two tertiary care centers in Ankara, Türkiye [University of Health Sciences Dışkapı Yıldırım Beyazıt Education and Research Hospital (January 1, 2015–October 1, …

Mirna-Target Gene Network Analysis In Siblings With Cystic Fibrosis And Phenotypic Variability, Ayberk Mustafaoğlu, Senem Noyan, Yeli̇z Z. Akkaya Ulum, Bala Gür Dedeoğlu, Nagehan Emi̇rali̇oğlu, Uğur Özçeli̇k, Ebru Yalçin, Deni̇z Doğru, Nural Ki̇per, Di̇dem Dayangaç Erden

Turkish Journal of Medical Sciences

Background/aim: Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF is characterized by respiratory tract infections, pancreatic insufficiency, meconium ileus, intestinal obstruction, and male infertility. A genotype to phenotype correlation is difficult to establish because of the heterogeneity of disease severity. Even patients with the same CFTR mutation can have varying clinical severities. In recent years, studies have explored the role of microRNA (miRNA) expression in the regulation of respiratory diseases. However, no research has been conducted to date on miRNAs in siblings with the same CFTR mutation. …

Metabolic And Genotypic Characterization Of Meropenem Susceptible And Resistant Serratia Marcescens Isolates, Şeyma Ni̇gi̇z, Gülşen Hazirolan, Gülşen Altinkanat Gelmez, Ceren Özkul Koçak, Engi̇n Koçak, Sevi̇lay Erdoğan Kablan, Emi̇rhan Nemutlu, Aycan Gündoğdu, Fatma Bayrakdar, Ufuk Hasdemi̇r, Deni̇z Gür

Turkish Journal of Medical Sciences

Background/aim: Serratia marcescens which is a nosocomial pathogen, is naturally resistant to a wide spectrum of antibiotics, which makes the management of infections difficult. The aim of this study was to determine the in vitro susceptibilities of S. marcescens to ceftriaxone, ceftazidime, meropenem, amikacin, gentamicin, ciprofloxacin, and to compare the metabolic profiles of meropenemresistant isolates under basal conditions and after exposure to sublethal concentrations of meropenem.

Materials and methods: A total of 84 S. marcescens isolates were included from various samples. Genes for meropenem resistance were determined by polymerase chain reaction (PCR). Genetic similarities among isolates of S. marcescens were …

Letter To The Editor Regarding “Kılıçarslan A, Kurt Çevik G, Doğan M, Aksoy Altınboğa A, Ceran F, Et Al. Does Cd47 Expression Have Prognostic Significance In Classical Hodgkin Lymphoma? Turkish Journal Of Medical Sciences: 2025; 55 (1): 22”, Burcu Baba, Ayşegül Akbay

Turkish Journal of Medical Sciences

No abstract provided.

Morphology, Evolution And Host-Driven Convergence In Ichneumonidae (Hymenoptera, Ichneumonoidea), Davide Dal Pos

Graduate Thesis and Dissertation post-2024

Understanding the functional and evolutionary significance of morphology is fundamental to interpreting the tree of life. In recent years, emerging tools have enabled broad-scale analysis of discrete morphological data and facilitated the study of entire phenomes, helping to re-establish morphology as a central component of evolutionary research. These advances allow us not only to examine individual traits in detail but also to compare them across taxa and explore their evolutionary trajectories. This approach is particularly critical when studying hyperdiverse groups that exhibit both high levels of morphological convergence and complex life cycles intricately tied to host use. A prime example …

Marine Ecosystem Services Disruption And Social Violence, Rafael Hurtado-Valdivieso

Graduate Thesis and Dissertation post-2024

Over the past century, human activities have profoundly altered ocean and coastal ecosystems, significantly impacting communities whose livelihoods depend on these environments. This dissertation explores how disruptions in marine ecosystem services contribute to the emergence of social violence in coastal communities, with a specific focus on the Colombian Caribbean. While prior research suggests a potential link between environmental degradation and conflict, empirical evidence remains limited and inconclusive. This study addresses that gap through a multi-method, interdisciplinary approach that integrates environmental science, political science, and computational modeling to examine the mechanisms linking ecosystem disruption to social violence.

The research follows a …

Bridging Data Gaps And Forecasting Challenges In Water Quality Monitoring Using Deep Learning, Rohan Gudla

Graduate Thesis and Dissertation post-2024

Reliable water quality monitoring is critical for protecting public health and enabling sustainable environmental management. However, high rates of missing data often exceed 40% due to sensor failures and operational disruptions severely undermine the utility of environmental monitoring systems. To address this challenge, this thesis presents a three-stage deep learning framework designed to enhance the accuracy and resilience of water quality forecasting. First, a Bidirectional Long Short-Term Memory model with Attention and Autoencoder Modules (BiLSTM-AAM) is introduced to impute long, irregular gaps in multivariate time series. Applied to real-world data from the St. Lucie River Basin, the model achieved a …

Computational Approaches For Rna Structural Motif Analysis: Similarities, Variations, And Spatial Relationships, Md Mahfuzur Rahaman

Graduate Thesis and Dissertation post-2024

The three-dimensional structures of RNA play a critical role in understanding their functions. One way to study the RNA 3D structure is by analyzing recurrent segments within the loop regions of RNAs, known as RNA structural motifs. These motifs can be grouped into families based on their structural features. However, the inherent structural diversity presents challenges in characterizing the similarities, variations, and spatial relationships within RNA motif families. This dissertation presents three computational methods that together provide a comprehensive framework for RNA structural motif analysis. First, RNAMotifComp establishes and visualizes relational networks among structural motif families. By analyzing instances of …

The Association Between The Social Determinants Of Health And Shared Decision Making: An Investigation Of The National Survey Of Children's Health, Vernon T. Headley

Graduate Thesis and Dissertation post-2024

Objective: Shared decision-making (SDM) is defined as a clinical approach that allows both physicians and patients to communicate on the best treatment options that will improve the patient's overall health outcomes. Shared decision-making plays a vital role in how parents engage with their physicians regarding the healthcare needs of their children. This dissertation assessed the association between the social determinants of health and shared decision-making regarding children’s health-related issues.

Methods: The data for the current research were the National Survey of Children’s Health (NSCH), combined 2017-2020. The dependent variable was shared decision-making and included discussing treatment options, raising concerns regarding …

Nueva Metodología De Análisis Para Determinar El Delito Ambiental De Ecocidio Por Glifosato En Cultivos Permanentes De Coca En Colombia, Rosalina González Forero, Jerry H. Kavouras, Érika González Ruiz

Biology Department Faculty Articles

El crimen organizado transnacional ha sido nefasto para el territorio colombiano, en especial el asociado a la producción de coca en la última década, lo que ha generado impactos económicos y sociales debido al aumento del conflicto e inseguridad en las zonas de influencia del cultivo. Esto se debe a que en el 2023 se tenían 230 000 hectáreas sembradas, lo que representa el 20 % de la superficie del país, con un impacto ambiental no cuantificado en términos penales. Este requiere de acciones de entidades estatales, así como de cooperación internacional, para adaptar estrategias y poder judicializar estos delitos …

Rna’S Symphony: Harmonizing Splice Junctions And Exon Counts For A Novel Approach To Differential Splicing Analysis, Jelard Aquino

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alternative Splicing (AS) plays a critical role in transcriptome complexity and cell-type-specific gene regulation, yet its analysis remains methodologically fragmented, especially in the context of noisy and sparse single-cell RNA sequencing (scRNA-seq) data. This dissertation addresses key computational challenges in AS detection by evaluating existing tools, developing integrative frameworks, and proposing new strategies for improving analysis accuracy in both bulk and single-cell contexts. In chapter 1, I present a comprehensive literature review of computational tools designed for detecting and quantifying AS from bulk and scRNA-seq data. This review outlines major methodological paradigms, including exon-based and splice junction-based approaches, and evaluates …

Effects Of Body Armor On Respiratory Muscle Fatigue And Muscle Blood Flow During Progressive Treadmill Marching, Kathryn Bell

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Torso-borne loads such as body armor are essential for modern military operations but impose mechanical and metabolic strain. These physiological stressors can trigger the inspiratory metaboreflex, which redirects blood flow from locomotor to respiratory muscles, further reducing muscle oxygen and endurance. While aerobic fitness has been shown to alleviate these effects, the interaction between sex, aerobic capacity, and oxygenation under load is not well understood. This study examined the physiological effects of torso-borne load carriage on respiratory muscle fatigue, skeletal muscle oxygenation, and exercise performance to volitional exhaustion and the degree to which sex and aerobic capacity influence these …

Hot Spring Associated Infectious Diseases In The Great Basin And Southwest, Matthew Bentz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Like all bodies of freshwater, natural hot springs can harbor pathogenic microorganisms that carry the threat of infectious disease. The unique chemistry, increased temperature, and popularity for bathing may alter the risk profile of hot springs compared to other natural bodies of water. Despite this risk, the role of hot springs as a reservoir for infectious diseases remains understudied, particularly within the context of regional public health. Nevada and the Great Basin/Southwest have increasingly promoted hot springs for the purposes of tourism, and they share a strong link to the cultural heritage of the region. The unknown risk profile and …

Morphological And Transcriptional Responses Of Mammalian Cells To Glucose Stress, Cassandra Burke

UNLV Theses, Dissertations, Professional Papers, and Capstones

Organismal cells encounter varying conditions, including daily and potentially seasonal fluctuations in available glucose. While some species tightly regulate circulating glucose levels, others tolerate extreme fluctuations, such as frugivorous bats experiencing post-prandial hyperglycemia and hibernating mammals maintaining stable glucose through torpor and hibernation. To investigate how these species-specific strategies influence cellular responses to glucose perturbation, primary dermal fibroblasts from nine mammals – humans, rats, Egyptian fruit bats, brown bear, 13-lined ground squirrel, little brown bat, gelada, honey badger, and Bactrian camel – were exposed to hypoglycemic (2.5mM), baseline (8mM), or hyperglycemic (30mM) treatment. Cell morphology was evaluated using Cell Painting, …

Functional Biopolymers Applied To Sustainable Technologies In The Environment And Healthcare, Fengjie He

UNLV Theses, Dissertations, Professional Papers, and Capstones

Biodegradable polymeric materials (biopolymers) are naturally derived materials known for their excellent biocompatibility, biodegradability, sustainability, and versatile chemical functionality. They have attracted increasing attention in various applications as alternative to synthetic materials ranging from food packaging to tissue engineering. Meanwhile, with intrinsic advantages, biopolymers have also emerged as promising materials in addressing contemporary challenges in both biomedical and environmental fields. Motivated by the significant potential of biopolymers and the growing need for sustainable materials, my research focuses on the design and engineering of biodegradable polymers with novel modification methods and application directions. In this work, two representative biopolymers are selected: …

Housewerk: How Drag Performers Engage In Emotional Labor While Navigating Community Care, Steph O. Landeros

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation examines drag performance as a form of service labor shaped by emotional labor, community care, and identity-based inequality. Drawing on interviews with drag performers shows how drag labor blends artistic skill, emotional regulation, interpersonal care, and entrepreneurial labor. While these demands mirror service sector roles in other industries, drag remains underrecognized and undervalued, particularly for performers who do not conform to white, cisgender norms. The study introduces Housewerk—an adaptation of Marlon Bailey’s concept of housework (Bailey, 2013)—to describe the mix of paid and unpaid labor drag performers engage in. Housewerk captures how performers must balance self-preservation (branding, income, …