Digital Commons Network^™

Targeted Depression Screening For At-Risk High School Students: An Integrated Review, Joseph Calub

DNP Qualifying Manuscripts

Depression in high school students is underrecognized because symptoms can present not only as mood issues but also behavioral or academic problems. This integrated review examined literature from 2010-2015 using PsycInfo, ERIC, CINAHL, and PubMed to evaluate the effectiveness of targeted depression screening for students referred for behavioral, academic, or social concerns. Studies meeting inclusion criteria assessed targeted or clinically referred screening methods, with a focus on validated tools such as the Patient Health Questionnaire modified for Adolescents (PHQ-A). Findings indicate that targeted screening effectively identifies depressive symptoms in at-risk students and is more feasible in resource-limited schools than universal …

Buddhism For Thinkers, Chang-Seong Hong, Sun Kyeong Yu

MSU Authors Collection

This book is an introduction to Buddhist philosophy. It uses the methods of analytic philosophy to approach the major topics of Buddhism.

Molecular Survey Of Leptospira Spp. And Bartonella Spp. In Alaskan Voles, Tabitha Page

Biological Sciences

Leptospira spp. and Bartonella spp. are two Gram-negative bacterial genera responsible for important zoonotic diseases worldwide, yet they remain poorly studied in northern ecosystems. Out objective was to assess Bartonella and Leptospira prevalence in vole populations in Interior Alaska and examine potential associations between prevalence and human activities (landscape and resource modification from sled dog kennels and reindeer farms). I surveyed for Bartonella and Leptospira in three vole species, Clethrionomys rutilis, Microtus pennsylvanicus, and Alexandronomys oeconomus, collected from three different areas in Interior Alaska in the summer of 2024. Using conventional PCR, I targeted the 16S rRNA gene for Leptospira …

Measuring Arctic Ground Squirrel Adult Neurogenesis In Caudal Hippocampus Using Dab/Dab-Ni Enzyme-Based Immunohistochemistry, Vy L. Nguyen

Chemistry and Biochemistry

Unconscious patients who are resuscitated after cardiac arrest often have a poor prognosis for neurological recovery and are routinely treated with therapeutic hypothermia as a standard of care. This intervention aims to reduce the risk of death and minimize brain damage. However, results from the Targeted Temperature Management 2 (TTM2) trial in 2021 indicate that cooling does not improve neurological outcomes in these patients. This finding raises questions about the neurological benefits, particularly regarding neurogenesis, of the rewarming phase of therapeutic hypothermia, as well as the effects of repeated cooling and rewarming cycles. Neurogenesis has been largely overlooked in therapeutic …

Ligand Substitution Versus Dna-Binding Affinity : ǂB Syntheses, Structures, And In Vitro Anticancer Activities Of Pt(Ch₃)₂I₂{2,2'-Bipy-N,N'-(Ch₃)₂} (N,N' = 4,4'; 5,5'; 6,6'), Shadrach Stitz

Chemistry and Biochemistry

In chemotherapeutic treatment for leukemia, the drug cisplatin is highly effective. However, there is an immense need for cisplatin analogues that are more clinically viable. Cancer cell assay studies have shown that the platinum(IV) complex Pt(CH₃)₂I₂{2,2'-bipyridine} exhibits significant anticancer activity against the human breast cancer cell line ZR-75-1, with an EC50 (effective concentration 50%) concentration of 6.1 μM— substantially lower than that of cisplatin (16.4 μM). To explore the unknown structure-activity relationship between DNA binding and anti-cancer activity, three isomers — Pt(CH₃)₂I₂{2,2'-bipy-n,n'-(CH₃)₂} where n,n’ = 4,4’; 5,5’; 6,6’— were synthesized. The intent was to demonstrate decreased cytotoxicity as complex-DNA steric …

The Wnba And Activism: A Case Study Of Power Of The Dream, Jakki Padilla

Communication

This thesis looks at how WNBA players used their platform to stand up for social and political change during the 2020-2021 season. This research focuses on the documentary Power of the Dream (Porter, 2024), which follows the Atlanta Dream and other WNBA players during a time of a global pandemic, racial injustice, and an election year. Guided by public relations scholars Bernays (1961), Curtain and Gaither (2007), Ciszek (2015) for my methodology. By using the Cultural-Economic Model (CEM) (Ciszek, 2015) and understanding their five interconnected components to guide understanding of activism in sports. By using thematic analysis (Braun & Clarke, …

A Contemporary Approach For Exploring The Influence Of Detoxification And Standardization Of Traditional Metallopharmaceutical Product Pharmacological And Toxicological Aspects, Malarvizhi K

Theses and Dissertations

Polyherbomineral formulation possess unique medicinal properties due to the presence of metals and minerals as integral part, as processed in addition to specific herbals. There is an increased interest in metallopharmaceuticals in clinical and research areas, because of their immense therapeutic efficiency towards multiple diseases and evidence for non-toxic claim. Sivanar Amirtham is one of the polyherbomineral Siddha medicine recommended for the treatment of various respiratory diseases and other ailments including antidote therapy for poisonous bites. The present research work attempted for standardization of Sivanar Amirtham preparation as per the traditional standard protocols (including the detoxification process of raw materials) …

Magnetic Molecularly Imprinted Polymers For Quercetin Adsorption: Fabrication, Characterization, And Application, Vinitha Ug

Theses and Dissertations

A highly selective Magnetic Molecularly Imprinted Polymer (MMIP) was developed for the detection and purification of Quercetin. The Density Functional Theory was utilized for the selection of suitable monomers based on binding energy interaction between quercetin and monomers (Acrylamide, Acrylonitrile, Methacrylic Acid). From computational studies, Acrylamide was selected as a suitable monomer for the synthesis of MMIP. Under ultrasound irradiation both quercetin and naringin imprinted materials MMIP-Q and MMIP-N were fabricated.

Compared to ultrasound-assisted synthesis, Microwave Synthesis provides uniform heat transfer throughout the reaction solution, which enables uniformity in the size of synthesised material, increases the yield of material and …

Facile Fabrication Of Protein-Polysaccharide Conjugate Multifilament Nerve Guidance Conduit For Peripheral Nerve Regeneration, Preethy Amruthavarshini R

Theses and Dissertations

Long segmental defects in peripheral nerves impair sensory and motor function by disrupting neural impulse transmission. End-to-end autologous grafting with proper fascicular complementation has demonstrated functional recovery per the Medical Research Council Classification (MRCC). However, obtaining donor nerve tissue exceeding 30 mm remains a significant challenge. Artificial hollow conduits serve as an alternative but are limited to defects smaller than 30 mm due to inadequate innervation across the lumen.

Multichannel nerve guidance conduits (mNGCs) have emerged as a promising solution by enhancing fascicular complementation similar to autografts. This study presents a two-step approach for fabricating nerve conduits with precise fascicular …

In Silico Investigations Of Class Ii Trans Activator (Ciita): Its Plausible Implications In Neuroinflammation And Neurological Disorders, Kishore N

Theses and Dissertations

Inflammation plays a significant role in maintaining homeostasis. Neuroinflammation is a chronic inflammatory response in the central nervous system (CNS), leading to brain or spinal cord dysfunction. To promote mental health, it is crucial to understand the regulation of neuroinflammation. Class II transactivator (CIITA) is a master-regulator of the major histocompatibility complex II (MHCII).

Modulation of CIITA has been suggested as a promising intervention for inflammatory conditions, including neurological disorders. However, there is limited knowledge about the role of CIITA and its interactors in inflammation. This study aimed to understand the role of CIITA in neuroinflammation and neurological disorders using …

3d Bioprinting On Electrospun Nanofibrous Scaffolds To Fabricate Myocardial Patches, Muthu Parkkavi S

Theses and Dissertations

Tissue-engineered three-dimensional (3D) myocardial patches offer superior and innovative treatment strategy for myocardial infarction (MI). Among the various scaffold fabrication techniques, electrospinning and 3D bioprinting have received great attention due to their ability to recreate native cardiac tissue mimetic characteristics. Despite several advantages, electrospun nanofibers have limitations in cell delivery due to random cell seeding, while bioprinting faces challenges in creating hydrogel constructs with ideal mechanical properties capable of supporting cardiac contraction/relaxation cycle. Hence in this work, hybrid myocardial patches were developed by converging electrospinning and bioprinting techniques.

Electrospinning of PLCL:PEOz (B73, 7:3 blend of poly-L-lactide-co-ε-caprolactone (PLCL) and polyethyl oxazoline …

Effect Of Osmolytes On The Interplay Of Water Protein And Dna In Ecori Dna Recognition Using Molecular Dynamics Simulations, Aathithya D

Theses and Dissertations

EcoRI is a type II restriction endonuclease that has been widely used as a model system to study protein-DNA interaction owing to its high degree of specificity. This enzyme does not recognize even a single basepair change in its recognition sequence, (GAATTC)2, under normal conditions. However, in the presence of osmolytes, such as glycerol and DMSO, the specificity of EcoRI is slightly relaxed and recognizes sequences that differ from its cognate sequence in the first basepair position. This relaxed specificity has been attributed to the dehydration of the EcoRI-DNA which presumably results in tighter complex formation and subsequent catalysis. However, …

Impact Of Ionic Liquids On The Treatment Of Various Derivatives Of Prosopis Juliflora For Removing Toxic Pollutants From Wastewater, Karthikeyan A

Theses and Dissertations

Water resources are increasingly contaminated by toxic pollutants, particularly industrial effluents, posing significant environmental concerns. Addressing the toxicity of these pollutants, especially those released from textile industries, presents challenges due to their harmful effects on living organisms. Various treatment methods are employed to mitigate this issue, including coagulation, flocculation, membrane filtration, photocatalytic degradation, adsorption, anaerobic processes, and chemical oxidation. Among these, adsorption emerges as an effective and economical method due to its minimal secondary contamination, negligible sludge production, and the use of inexpensive agricultural and marine waste materials.

This study examines the ability of Prosopis juliflora treated with imidazolium-based ionic …

Ai Based Early Detection Of Hormonal Imbalance And Poly-Cystic Ovary Syndrome In Young Women, Reka S

Theses and Dissertations

A hormonal disorder, Poly-Cystic Ovary Syndrome (PCOS) usually affects women during the reproductive age. It is characterised by imbalances in hormones, particularly a rise in the female body's androgen level (male hormone) and enlarged ovaries with small cysts. PCOS can cause ovarian cysts, weight gain, acne, excessive hair growth, insulin resistance, and irregular menstrual cycles along with other health problems. While the exact origin of PCOS is uncertain and its symptoms are unclear, diagnosing PCOS in real-world conditions is a difficult task. Therefore, prompt and precise PCOS diagnosis is essential for efficient treatment and for averting long-term issues.

Clinicians typically …

Biogenic Calcite Precipitation For Coastal Sand Stabilization: A Synergistic Approach Using Marine Bacteria And Natural Fibers, Aparna Gs

Theses and Dissertations

Coastal erosion, driven by natural forces such as waves, tides, winds, and currents and further intensified by anthropogenic activities like urbanization, climate change, and coastal infrastructure development, poses a significant threat to shoreline stability. Conventional erosion control methods, including jetties, embankments, and artificial reefs, often face limitations in sustainability and effectiveness. In this context, microbially induced calcite precipitation (MICP) has emerged as a promising ecofriendly solution for ground stabilization.

The present study investigates the potential of an indigenous ureolytic marine bacterium, Bacillus sp. N₉, isolated from the coastal sediments of Nagapattinam, Tamil Nadu, for coastal sand stabilization. The strain was …

Bioprospecting Of Wheat Straw Pyrolysis Aqueous Phase To Combat Multi-Drug Resistant Pathogens, Srividhya K

Theses and Dissertations

Hospital-acquired infections (HAIs) significantly contribute to the emergence and spread of antimicrobial resistance (AMR), primarily through the contamination of high-touch surfaces. Current disinfectants have drawbacks like high environmental persistence, ecotoxicity, and resistance development, prompting the need for environmentally friendly alternatives.

One potential approach is pyrolysis, during which the biomass components are broken down into solid, liquid, and pyro-gas. The aqueous phase of the liquid fraction is usually discarded as waste, but it contains a variety of organic compounds that have the potential for antibacterial and antifungal activity. The present study assessed the anti-infective and anti-biofilm properties of wheat straw pyrolysis …

Design And Investigation Of Deep Eutectic Solvent-Assisted Extractive Fermentation Of Biomolecules, Ramya M

Theses and Dissertations

The increasing demand for sustainable and efficient bioprocessing techniques has prompted the development of novel separation strategies integrating bioproduction with downstream processing. Extractive fermentation has emerged as a promising process intensification to overcome product inhibition and enhance productivity by constantly removing target biomolecules from the fermentation medium. Although the extractive fermentation of acids and alcohols has been extensively studied, less attention has been focused on green solvents and their compatibility, phase-forming abilities, and reactor configurations.

Therefore, advancing extractive fermentation technology necessitates comprehensive studies on solvent systems and the development of modified bioreactor configurations to aid future optimization. Initially, 22 DESs …

Fabrication Of Protein-Based Nanomicelle Against Inflamed Synoviocytes In Rheumatoid Arthritis, Madhumithra Thangadurai

Theses and Dissertations

Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by persistent synovial inflammation, progressive cartilage and bone destruction, and systemic complications. 1% of the global population are affected by RA, when their immune system targets synovial tissues, leading to joint pain, swelling, and functional disability. Standard treatments, such as disease-modifying antirheumatic drugs (DMARDs) like methotrexate (MTX), are limited by systemic toxicity and inconsistent patient responses, highlighting the need for improved therapies. This research work explores protein-glycosaminoglycan nanomicelles engineered using Zein with Chondroitin or carboxymethylated Dextran Sulfate as targeted drug delivery vehicles for RA.

MTX was encapsulated within these nanomicelles to …

Metal-Organic Frameworks And Nanostructured Materials For Environmental Applications, Arunkumar G

Theses and Dissertations

The global population and economic development are experiencing rapid growth. Concurrently, environmental challenges such as global warming, soil, water, and air pollution are also rising. Each year, approximately 700,000 tonnes of products are generated from 100,000 tonnes of commercial dyes. Following their use, these dyes are often released into water bodies.

This contamination of water and land results in the formation of mutagenic and carcinogenic substances harmful to living organisms. Therefore, it is imperative to treat industrial wastewater to enable its recycling for various applications. Parallelly, the vehicles are becoming indispensable to human life modern world's urbanization and advancement.

The …

Dissolved And Particulate Nutrient Dynamics In The Northern Gulf Of Alaska: A Productive Subarctic Shelf Ecosystem, Emily Ortega

Oceanography

The Northern Gulf of Alaska (NGA) is a biologically productive system, culturally and economically sustaining Alaska’s coastal communities, with inorganic nutrients as an important foundation of this important food web. Nonetheless, seasonal cycles, interannual variability, and nutrient chemistry all influence nutrient dynamics, creating challenges in the overall understanding of the NGA ecosystem and the resources it provides. Therefore, this work examines nutrient sources, sinks, and trends over time and location to identify and explain key nutrient dynamics within the NGA. One key process is the exchange between dissolved (potentially bioavailable) and particulate nutrients that is examined in Chapters Two and …

Perspectives On Northern Gulf Of Alaska Freshwater Pathways, Wind, And Linkages To Phytoplankton Biomass, Isaac Reister

Oceanography

The biologically productive northern Gulf of Alaska continental shelf receives freshwater from surrounding watersheds and wind stress from atmospheric pressure systems. A better characterization of the relationship between wind and salinity spatiotemporal variability is important for understanding the fate of freshwater and its ecological importance. In Chapter 2, I analyzed 25 years of northern Gulf of Alaska hydrographic data to reveal mid-shelf and shelf­ break freshwater pathways that impact stratification, currents, and freshwater distribution. Process studies of the Copper River plume’s propagation towards the shelf-break and beyond inform ecological function on the northern Gulf of Alaska shelf and productivity in …

Optimal Control And Inverse Problems For Partial Differential Equations And Variational Inequalities, Olha Sus

Mathematics and Statistics

This dissertation addresses optimal control problems for nonlinear evolutionary variational inequalities involving Volterra-type operators and inverse problems for the Dirac system on finite metric graphs. The first part presents the historical background, novelty, and motivation behind the research studies. In the second part, we focus on solving the initial value problem for nonlinear evolutionary variational inequalities with Volterra-type operators, proving the existence of a unique solution using the Banach fixed-point theorem. The third part explores an optimal control problem for these inequalities, establishing the existence of a solution under specific assumptions on the given data. In the last part of …

Exploring The Intersection Of Race And Native Speakerism In English Language Teaching: Experiences Of Black African Teachers In Turkey, John Ayodeji Odudele

Linguistics

Research on race and native speaker status in language teaching provides little insight into the experiences of Black African English teachers (BAETs) in the diaspora. To address this gap, this study examines how aspects of BAETs' positionalities - such as race and native speaker status create challenges in their professional and societal lives in Turkey. Data from twelve semi­ structured interviews of BAETs were analyzed using thematic analysis. Findings suggest that race­ related challenges trump language-related ones and that Blackness fundamentally shapes outsiders’ perception and value of BAETs’ linguistic expertise. Even when BAETs possess the same or superior qualifications as …

Benthic Community Composition And Ecosystem Function In Southern Kachemak Bay, Alaska, Jonah Jossart

Marine Biology

The benthic environment in southern Kachemak Bay, Alaska provides critical ecosystem services, processing organic matter from the land and the sea, and returning nutrients to the food web. In Kachemak Bay, concerns have arisen that marine agriculture (mariculture) operations in the form of salmon hatcheries and oyster farms may have negative impacts on the local environment. This thesis investigates the seafloor sediment environment to assess these potential impacts under salmon hatchery net pens in Tutka Bay Lagoon, and under an oyster farm in Jakolof Bay. We found that beneath the net pens, high waste inputs of fish food, feces and …

Factors Affecting Nest And Brood Survival Of Rock Ptarmigan (Lagopus Muta) In Interior Alaska, Robert Wiltzen

Biological Sciences

Rock ptarmigan (Lagopus muta) are a circumpolar species endemic to high elevations and latitudes of North America and are common throughout Alaska. The r- selected life history of ptarmigan indicates that reproduction and specifically nest and brood survival is the most important component of population growth. However, factors affecting these population parameters have not been studied extensively or intensively, since there have only been three studies done in Alaska. Rock ptarmigan exhibit population fluctuations, which may be caused by changes in reproduction and survival due to predation and weather events. Warming climatic patterns and shifts in the range of their …

Strontium Isotope Movement Modeling Of Modern And Ancient Megafauna In Alaska, Audrey Rowe

Biological Sciences

Strontium isotope analysis is a technique that can be used to infer the geographic origin of biological materials. The strontium isotope ratios (87Sr/86Sr) of biological tissues can be matched to locations on a modeled strontium geographic distribution (“isoscape”) with similar 87Sr/86Sr. In this dissertation, I measured 87Sr/86Sr and other stable isotopes along the length of a mammoth tusk to model its lifetime movement and infer details about its food sources and nutritional status. I then adapted this modeling method to caribou tooth enamel to compare modern and premodern caribou space use in interior Alaska and built a new 87Sr/86Sr isoscape …

Investigation Of Dependency Parsing Techniques For Digital Document Analysis Through Deep Learning Approach, Rekah D Ms

Theses and Dissertations

Digital document dependency parsing is a significant task in natural language processing. Dependency parsing supports verification of the grammatical correctness of a sentence besides enabling extraction of relevant documents. Inappropriate extraction of features may result in falsely parsing a document, leading to decreased accuracy. Machine learning methods have been employed to perform feature extraction. However, selecting pertinent features was never achieved which minimizes the time consumption and overhead.

Hence, novel machine learning and deep learning techniques have been designed in our work for accurate and computationally efficient digital document analytics through dependency parsing. Four different contributions have been proposed for …

Bridging Scales In Epidemic Modeling From Individuals To Networks And Ecosystems, Saiprasasd Vr

Theses and Dissertations

Epidemics have shaped the trajectory of human history, repeatedly exposing vulnerabilities in healthcare systems and influencing socio-economic dynamics on a global scale. The COVID-19 pandemic, in particular, underscored the pressing need for flexible and responsive modeling framework capable of adapting to dynamic and evolving epidemic scenarios. Motivated by these challenges, this thesis explores the development of innovative epidemic models that integrate classical mathematical modeling techniques, network-based frameworks, and modern data-driven approaches. Each chapter addresses a distinct dimension of epidemic spread, from vaccination dynamics and community coupling to ecological complexity and adaptive human behavior, culminating in a model-free paradigm suitable for …

Genomic Surveillance Of Indian Klebsiella Pneumoniae And Exploration Of Resistance Inhibitors, Abhirami Ks Ms

Theses and Dissertations

Klebsiella pneumoniae is an important ESKAPE pathogen that causes life threatening infections. The strains exhibiting multidrug-resistance (MDR) and hypervirulence are the priority pathogens for which immediate treatment and dissemination prevention strategies are required. To address this, genome profiling was performed to understand the AMR patterns, role of episomes, phages, virulence determinants and its association with sequence types.

The study includes 267 publicly available Indian K. pneumoniae genomes over a period of ten years and four sequenced isolates. Whole genome analysis revealed the widespread presence of diverse β-lactamase genes, with β-lactam resistance being predominant. Genes such as blaCTX-M-15, blaTEM-1B and blaOXA-232 …

An Investigation Of Ichthyophonus Infection Related In-River Mortality In Yukon River Chinook Salmon From Multiple Knowledge Systems: Indigenous, Local, And Western Science, Keith D. Herron

Fisheries

The recent historic low salmon returns in the Yukon River contribute to an ongoing humanitarian crisis for subsistence users and Indigenous Peoples with cultural and well-being ties to salmon. After over a decade of relative calm, the marine parasite Ichthyophonus has undergone a resurgence and is once again infecting Yukon River Chinook salmon (Oncorhynchus tshawytscha; king; Taryaqvak; Ggaal; Gath; Łuk choo, hereafter referred to as king salmon) at high rates, with currently unknown consequences for survival of migrating adults. This thesis pairs multiple knowledge systems to assess the prevalence, severity, and impact of Ichthyophonus on adult Yukon River king salmon …