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Antidepressant Medication Nonadherence In Adult Patients With A Major Depressive Disorder, Sandrine Djou Kaze

Walden Dissertations and Doctoral Studies

The chosen approach for the Doctor of Nursing Practice (DNP) project was a clinical practice guideline (CPG) on interventions to improve antidepressant medication adherence in adults diagnosed with depression in an outpatient setting. The consequences of medication nonadherence in patients with depression are devastating for individuals and the healthcare system. Therefore, addressing it within nursing practice is essential to improve treatment efficacy and patient outcomes. The practice question related to the DNP project was to determine whether the CPG could improve antidepressant medication compliance in adults diagnosed with a depressive disorder in an outpatient setting. I aimed to develop a …

Targeted Proteomic Analysis Identifies Acvrl1 As A Marker Of Cerebral Edema In Aneurysmal Subarachnoid Hemorrhage, Bosco Seong Kyu Yang, Lena O'Keefe, Sarah Hinds, Hua Chen, Athziry Paz, Jude Savarraj, Han-Gil Jeong, Moon-Ku Han, Aaron Gusdon, Xuefang Sophie Ren, Spiros Blackburn, Huimahn Alex Choi

Faculty, Staff and Student Publications

Cerebral edema (CE) is a major component of early brain injury from aneurysmal subarachnoid hemorrhage (SAH). Despite the utility of blood-based protein markers, biomarkers targeting cerebral edema have yet to be developed. We performed a targeted proteomic search analyzing 141 proteins in plasma samples taken from 80 adult patients within 48 hours after aneurysmal rupture to identify plasma biomarkers of cerebral edema. The protein expression profiles were analyzed for associations with a higher level of the subarachnoid hemorrhage early brain edema score measured in admission computed tomography scans. Five differentially expressed proteins-brorin, ectodysplasin A2 receptor, layilin, scavenger receptor class A …

Multi-Ancestral Genome-Wide Association Study Of Clinically Defined Nicotine Dependence Reveals Strong Genetic Correlations With Other Substance Use Disorders And Health-Related Traits, Emma C Johnson, Jared V Balbona, Alexander S Hatoum, David A A Baranger, Louis Fox, Paul W Jeffries, Laura J Bierut, Andrew C Heath, Pamela A Madden, Elliot C Nelson, Arpana Agrawal, Et Al.

2020-Current year OA Pubs

BACKGROUND: Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement.

METHODS: We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry [EUR], 10,231 of African ancestry, and 3,746 of East Asian ancestry) and compared the results to other nicotine-related phenotypes.

RESULTS: We replicated the well-known association at the

CONCLUSIONS: Our results suggest that combining the wide availability of diagnostic EHR data with nuanced criterion-level analyses of DSM tobacco use disorder may produce new insights into the genetics …

The Promise And Peril Of Comparing Fluorescence Lifetime In Biology Revealed By Simulations, Pingchuan Ma, Peter Chen, Scott Sternson, Yao Chen

2020-Current year OA Pubs

Signaling dynamics are crucial in biological systems, and biosensor-based real-time imaging has revolutionized their analysis. Fluorescence lifetime imaging microscopy (FLIM) excels over the widely used fluorescence intensity imaging by allowing the measurement of absolute signal levels independent of sensor concentration. This capability enables the comparison of signaling dynamics across different animals, body regions, and timeframes. However, FLIM's advantage can be compromised by factors like autofluorescence in biological experiments. To address this, we introduce FLiSimBA, a flexible computational framework for realistic

First-Line Pd-1 +/- Ctla-4 Blockade In Patients With Deficient Mismatch Repair And/Or Microsatellite Instability-High Metastatic Colorectal Cancer, Vincenzo Nasca, Gabriele Tinè, Julien Taieb, Sara Lonardi, Ben Boursi, Ofer Margalit, Lisa Salvatore, Romain Cohen, Javier Ros, Margherita Ambrosini, Koen Zwart, Jeanine Roodhart, Priya Jayachandran, Michael J Overman, Maria Elena Elez, Chiara Cremolini, David Tougeron, Miriam Koopman, Thierry André, Rosalba Miceli, Filippo Pietrantonio

Faculty, Staff and Student Publications

Background: Patients with deficient mismatch repair (dMMR) and/or microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) show marked sensitivity to immune checkpoint inhibitors (ICIs). Dual PD-1/CTLA-4 blockade with nivolumab and ipilimumab showed superior progression-free survival (PFS) over chemotherapy and anti-PD-1 monotherapy, but data on treatment-naïve patients is not available yet.

Methods: This international multicenter study included patients with dMMR/MSI-H mCRC receiving either chemotherapy with or without biologics, or anti-PD-1 monotherapy, or dual PD-1/CTLA-4 blockade as a first-line treatment. Data were adjusted using inverse probability of treatment weighting (IPTW) to account for baseline imbalances. IPTW-adjusted survival and subgroup analyses were conducted.

Results: …

Ecological Drivers And Temporal Dynamics Of Daphnia In A Diverse Environmental And Spatial Landscape, Crysta A. Gantz

Dissertations and Theses

In the modern era, commonly referred to as the Anthropocene, human-caused changes to the environment are prevalent and complex. The study of impacts to biodiversity and ecosystem functioning requires multi-faceted approaches that encompass scales of organization from genes to ecosystems. It is often difficult to tease apart whether species responses to environmental change are due to phenotypic plasticity or genotypic variation. Therefore, it is important to try to understand where variation originated, that is, to link a phenotypic response to a genetic change or to gauge whether the response is from the environment. In addition, neutral genetic variation arising from …

High Abundances Of Crustose Coralline Algae Inside Cryptic Coral Habitats Linked To Coral Reef Functioning, Anna Rothstein, Orion S. Mccarthy, Sophie Luu, Emily L.A. Kelly, Philip Heller, Stuart Sandin, Jennifer E. Smith, Maya S. Devries

Faculty Research, Scholarly, and Creative Activity

Cryptic habitats on coral reefs consist of crevices, tunnels, and holes that are estimated to comprise 30%–75% of the total reef surface area. These large habitats are vastly understudied because they are often difficult to access. Crustose coralline algae (CCA) are thought to perform important ecological functions, including calcium accretion, both inside cryptic habitats and on the exposed (top) reef. Using GoPro cameras, we surveyed 250 coral crevices from 13 reefs on West Maui, Hawai‘i. We compared relative CCA cover between crevice microhabitats and the well-studied top-reef and identified abiotic and biotic factors that correlated with CCA abundance. We found …

Late Holocene Paleodietary Patterns Among The Ancestral Ohlone: Ecogeographic Partitioning Of Resources Along The San Francisco Bay Eastern Shore, Melanie M. Beasley, Eric J. Bartelink, Alan Leventhal, Monica V. Arellano, Richard Massiatt, Charlene Nijmeh

Faculty Research, Scholarly, and Creative Activity

Objectives: In the San Francisco Bay Area, Late Holocene resource intensification models predict an increase in diet breadth and a reduction in foraging efficiency associated with an increase in population, sedentism, and territoriality among fisher-hunter-gatherer populations. Here we compare bone stable carbon (δ¹³C) and nitrogen (δ¹⁵N) isotope values of sites along the eastern bay shore to interpret how ecogeographical partitioning of resources by latitude and distance from the bay reflects differential access and control of resources. Materials and Methods: With the support of, and in collaboration with, the Muwekma Ohlone Tribe of the San Francisco Bay …

Use Of Cigarettes, Cannabis, And Alcohol Among Asian American, Native Hawaiian, And Pacific Islander Adults: Community-Based National Survey Analysis, Vuong Van Do, Van My Ta Park, Nhung Nguyen, Pamela May Ling, Marian Tzuang, Bora Nam, Marcelle M. Dougan, Oanh L. Meyer, Janice Y. Tsoh

Faculty Research, Scholarly, and Creative Activity

Background: Asian American, Native Hawaiian, and Pacific Islander (AANHPI) populations have diverse cultural, immigra-tion, and sociodemographic characteristics. Aggregated data could mask substantial differences in substance use between cultural subgroups in this population. Yet, studies examining substance use among the AANHPI population are limited. Objective: This study aimed to describe cigarette, cannabis, and alcohol use among AANHPI adults by cultural subgroup and sex. Methods: We analyzed data from 3411 AANHPI respondents of a multilingual national survey “COMPASS” during December 2021-May 2022. Primary outcomes were self-report current (every day or some days) use of cigarettes, cannabis, and alcohol. Cultural subgroups included Asian …

Strategies To Develop Professional Identity Of Teachers From Non-Education Faculty: A Case Study, Klara Tyas Sulistyawati, Paulus Kuswandono

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Nowadays, teachers do not always graduate from the education faculty. This phenomenon attracts researchers to conduct a study about the strategies to develop teacher professional identity, specifically for teachers from non-education faculty. In this study, the researchers implemented a case study method. To collect the data, the researchers distributed a closed-ended questionnaire to six teachers from the non-education faculty and did interview sessions. The researchers concluded the three major findings, namely (1) perceiving oneself, (2) gaining valuable insight through the teacher community, and (3) doing reflection on previous teaching experiences.

Enhancing Student Engagement And Cognitive Development Through Game-Based Learning (Gbl), Kusuma Rani, Putri Dwi Lestari, Saenab Ka-Lupae

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Elementary school students are classified as playing-age children, they like to do activities while playing. This research aims to determine the influence of the Game-Based Learning (GBL) learning model on students' cognitive activities and abilities. This type of research is quasi-experimental, one-group pre-test and post-test design. The population of this study were Madrasah Ibtidaiyah students at Darussalam Seuksa School, Thepa, Southern Thailand. The research sample for grade 5 students was 28 students. Student activity is measured using an observation sheet with indicators measured using a 1-5 Likert scale. Cognitive abilities are measured by tests. The results of data analysis showed …

Pembelajaran Berbasis Proyek Dalam Pembelajaran Ilmu Pengetahuan Alam Untuk Meningkatkan Hasil Belajar Siswa, Agustinus Tanggu Daga, Matias Hota Heli, Petrus Lende

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Penerapan Ilmu Pengetahuan Alam di sekolah dasar sebagai salah satu mata pelajaran mendukung pelaksanaan pendidikan abad 21. Masalah yang sering ditemui adalah pengetahuan yang kirang pada siswa tentang esensi keilmuan Ilmu Pengetahuan Alam yang berdampak pada kinerja, baik dalam proses pembelajaran maupun dalam hasil belajar. Penelitian ini mengkaji secara ilmiah dampak terhadap hasil belajar dalam pembelajaran berbasis proyek (PjBL). Untuk itu diambil 18 siswa kelas V sebagai subyek penelitian. Penelitian ini menggunakan pendekatan kuantitatif dan metode kuasi eksperimen. Tes hasil belajar digunakan sebagai instrument pengumpulan data yang diterapkan sebelum dan sesudah intervensi. Analisis data mencakup beberapa pendekatan yaitu analisis deskriptif, …

Synthesis And Characterization Of Near-Infrared Fluorescent Dye Cy7-2 For Targeted Cancer Imaging, Eleanor Yerkin

Summer Research Showcase

The growing demand for real-time, precise, cancer diagnostics and treatment has driven the development of targeted near-infrared (NIR) fluorescent biosensors. Traditional visible-range fluorophores, such as Boron-dipyrromethene (BODIPY) dyes are well-known for their high quantum yields, photostability, biocompatibility, and sharp absorption and emission peaks, making them widely used in fluorescence imaging (Nisar and Sui). However, Cyanine dyes offer some advantages over visible-range dyes, such as deeper tissue penetration due to their near-infrared (NIR) absorption and emission, significantly reduced background autofluorescence, and improved signal-to- noise ratios in vivo (Zhang et al.). This project explores the synthesis and characterization of the NIR fluorescent …

Problematic Ideas For A Problematic Group: Untangling Common Depictions Of Transgender Characters In Young Adult Literature, Asiyah Noujdi

Summer Research Showcase

The need and desire for diverse perspectives within young adult (YA) literature led to a boom in the amount of stories featuring trans people at the start of the 21st century and has continued to this day. However these perspectives have not all been positive with earlier books written featuring viewpoints that would be seen by a trans individual as not reflective of their lived experiences. This project aims to compare the depictions of trans people in trans YA from the start of the 21st century up to the present day. The perspectives used within this project will be from …

Penerapan Model Pembelajaran Kooperatif Tipe Talking Stick Untuk Meningkatkan Hasil Belajar Siswa Pada Pelajaran Ipas, Yusdin Bin M. Gagaramusu, Wildani Wildani, Rizal Rizal, Sisriawan Lapasere

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Penelitian ini bertujuan untuk memberikan wawasan mengenai penerapan model pembelajaran kooperatif tipe talking stick sebagai upaya meningkatkan hasil belajar siswa pada mata pelajaran IPAS kelas IV SD Negeri 9 Mamboro. Jenis penelitian yang dilakukan adalah Penelitian Tindakan Kelas (Classroom Action Research) yang dikembangkan oleh Kemmis dan Mc Taggart yang terdiri dari empat tahapan, yaitu: (1) Perencanaan, (2) Tindakan, (3) Observasi, dan (4) Refleksi. Penelitian ini dilaksanakan di SD Negeri 9 Mamboro, pada tahun ajaran 2024/2025 dengan subjek penelitian berjumlah 23 siswa kelas IV. Dalam penelitian ini, teknik pengumpulan data meliputi tes dan non-tes. Hasil penelitian menunjukkan bahwa selama proses pembelajaran …

U.S News & World Report 2025 Graduate Program Rankings, Unlv & Unr, Dre Boyd-Weatherly, Caitlin J. Saladino, William E. Brown Jr.

Higher Education

This fact sheet presents 2025 graduate program rankings for the University of Nevada, Las Vegas (UNLV) and for the University of Nevada, Reno (UNR) based on the data published in spring 2025 by U.S. News & World Report. The graduate program categories reported include business, education, engineering, fine arts, law, medicine and health care, sciences and mathematics, and social sciences and humanities.

Innocence Stolen, Echo K. Yerke

Master of Arts in Human Services

Childhood sexual abuse (CSA) is a negative societal problem. It isn’t an easy problem to solve; there is a lot of secrecy involved. The literature review will look at early interventions and prevention. The paper tries to show how it would benefit society if there were more money dedicated to programs to prevent childhood sexual abuse. The paper shows the negative outcomes that happen to the victims and possibly their future generations. The paper will look at the relationship between childhood sexual abuse (CSA) and suicide. It also looks at the mental health struggles that victims go through. It also …

Beyond The Bottle: The Lifelong Consequences Of Fetal Alcohol Spectrum Disroder, Victoria M. Van Curen Ms.

Master of Arts in Human Services

With increasing numbers of Fetal Alcohol Spectrum Disorder, the focus is on FASD and the impact it has on mothers’, their unborn child, and the consequences that will lead to long-lasting effects. Once women find out that they are expecting, they stop drinking alcohol, but there is still statistic that shows about 8% of women reported that they continue to consume alcohol during their pregnancy. The paper will also include multiple real-life examples of studies that have been conducted on individuals with FASD. With studies focusing on individuals with FASD, it will also include different populations with FASD, and the …

Unmasking The Shadows: A Comprehensive Exploration Of Serial Killers, Erica D. Lewis

Master of Arts in Human Services

Using a mixed-methods approach that combines quantitative literature review and qualitative case study analysis, this capstone investigates the developmental pathways of serial killers. The study investigates a variety of biological, psychological, and sociological elements—such as genetic predispositions, neurological disorders, childhood traumas, and environmental stressors—interact to shape serial killers. The study offers a multidisciplinary perspective, grounded in criminological models such as routine activity and labeling theories, sociological frameworks such as social disorganization and strain theory, and psychological theories such as psychopathy and attachment theory. Theoretical findings are contextualized through case studies of notorious serial killers like Ted Bundy, Jeffrey Dahmer, and …

Re-Engaging Driver Attention Using Chatgpt: A Multimodal Study On Stress Impact And Driving Performance, Alaa Zaki Elfiqi

Theses and Dissertations

Driving is considered a complex task that requires continuous focus and attention from the driver. Driving performance can also be impacted by changes in the driver’s stress level. However, limited research explores methods to address this challenge. With the current advances in Large Language Models (LLMs) and their ability to engage in human-like interaction, this study investigates the potential of using ChatGPT, designed to speak Egyptian Arabic, in re-engaging driver attention under different driving scenarios for low-stress and high-stress conditions within a virtual reality (VR) environment driving simulator. Drivers were asked to follow a leading car into two scenarios with …

Enhanced Meropenem Activity And Stability Following Load In Polyvinyl Alcohol Nanofiber Scaffolds With Sitagliptin As Quorum Sensing Inhibitor On Pseudomonas Aeruginosa, Samar A. Salim, Abdelrhman Mohsen, Mohamed Emara, Taghrid Elmahdy

Nanotechnology Research Centre

Background The increasing resistance of bacteria to conventional antibiotics poses a significant health challenge. Innovative strategies, such as combining antibiotics with agents like quorum sensing inhibitors (QSIs), have been developed to combat this issue. QSIs enhance antibiotic efficacy without inhibiting bacterial growth, minimizing the risk of resistance. Aims Evaluate the combined effect of Sitagliptin (STG) as a QSI with Meropenem (MER), fabricate drug-loaded Polyvinyl Alcohol (PVA) nanofibers, and investigate their antimicrobial activity against standard Pseudomonas aeruginosa (PAO1) and carbapenem-resistant P. aeruginosa (CRPA). Methods The combinatorial effect was assessed using a checkerboard assay. PVA/STG, PVA/MER, and PVA/STG/ MER nanofibers were fabricated …

Exposure To Zinc Oxide Nanoparticles Reveals A Death Resistance Mechanism In Dictyostelium Discoideum, Zoya Nadeem Faruqui

Theses and Dissertations

Zinc oxide nanoparticles (ZnO NPs) are very versatile due to their multifunctional properties including unique physicochemical and antimicrobial characteristics. They are widely utilized across various fields such as biomedical, industrial fields, environmental remediation, and agriculture. Therefore, their cytotoxic effects on biological systems necessitate a deeper understanding of the cellular responses to nanoparticle exposure. This project primarily investigates the impact of ZnO NPs on the model organism Dictyostelium discoideum AX4 (social amoeba) which has not been examined before unlike a vast variety of organisms in the literature. The cytotoxic effects of ZnO NPs on Dictyostelium discoideum AX4 cells are compared with …

Emotional Development In Infancy, Claire Sanford, Samantha Gott

Florida Atlantic Undergraduate Research Journal

Developmental science has documented that infants’ emotional reactions are shaped by individual dispositions and their environment. This study investigated fear responses along with patterns of brain development in infants 6 to 10 months. Nine infant-mother dyads participated, with each infant observed twice (18 visits). An electroencephalogram (EEG) was used to analyze brain activity during resting-state and fear-eliciting conditions. Infant fear vocalizations were evaluated and coded during two conditions, i.e., an unfamiliar object (an electronic toy-spider), and an unfamiliar adult approaching. Results indicated infants’ fear vocalizations were stimuli-specific, with more fear expressed towards approaching strangers than the novel object. Findings also …

Impacts Of Climate Change On Vertical Migration Of Zooplankton Species, Camila Rimoldi Ibañez

Florida Atlantic Undergraduate Research Journal

Vertical migration in marine and freshwater environments stands as one of Earth’s largest daily animal movements concerning biomass. It serves as a crucial life pump, shaping phytoplankton grazing patterns, facilitating nutrient transport through the water column, and providing vital sustenance for deep-water organisms lacking access to surface phytoplankton. Despite enduring millennia of climatic shifts, contemporary anthropogenic climate change surpasses historical rates of change, posing unprecedented challenges. Climate-induced phenomena increasingly affect various species, including vertical migrators. This paper delves into Diel Vertical Migration’s ecological significance and anticipates detrimental effects of climate change on individual animals’ physiology and migration patterns. Foremost, rising …

The Relationship Between Self-Reported And Observer-Rated Maternal Anxiety During Mother-Infant Interactions, Annalisa Tran, Jacqueline Hammack

Florida Atlantic Undergraduate Research Journal

Research pertaining to maternal anxiety and mother-infant interactions is a rapidly growing field. The purpose of this study is to investigate the relationship between self-reported maternal anxiety ratings and observer-rated maternal anxiety scores. Thirty-nine motherinfant dyads participated in a four-minute free-play session via Zoom. The Parent Anxiety measure from the Coding Interactive Behavior scale was used to measure observed maternal anxiety. The General Anxiety Disorder-7 scale was used to measure self-reported maternal anxiety. No significant association was found between self-reported maternal anxiety and observed maternal anxiety. An exploratory analysis was conducted to compare self-reported maternal anxiety and observed maternal sensitivity. …

Use Of A Novel Plant Essential Oil-Based Insecticide For Insect Control In Household Gardens And Lawns, Mia Michnik, Alysa Suissa, Liah Brussolo Cremona, Annalise Wellman, Nicholas Nifakos, Alexander Spanoudis, John M. Harlin

Florida Atlantic Undergraduate Research Journal

Insecticide use has increased as population and agricultural demand for crops grows. Commercial insecticides contain active ingredients that are often harmful to humans and the environment. A viable alternative to this concern is developing and using insecticides with low toxicity and minimum risk to the environment. In this study, we sought to empirically assess the effectiveness of an insecticide based entirely on plant essential oil active ingredients, which contain complex secondary metabolites. Our results show that a concoction of several plant essential oils was effective in killing a wide range of household garden insect species and bedbugs, encompassing five orders …

Biographies, Editorial Team

Florida Atlantic Undergraduate Research Journal

No abstract provided.

Mechanism Of Unconventional Il-33 Release In Airway Disease, Omar Osorio

Arts & Sciences Graduate Student Theses and Dissertations

The alarmin cytokine IL-33 is a strong inducer of type two inflammation and has been implicated in various chronic lung diseases. Although much work has been done to understand the inflammatory effects of extracellular IL-33, there is still a knowledge gap in understanding how this cytokine is secreted by airway epithelial cells in steady-state conditions. In the work laid out in this document, a COPD-disease associated isoform of IL-33, that has exons 3 and 4 (IL-3334) spliced out and is tonically secreted at baseline conditions. This IL-33 isoform is secreted from airway epithelial cells alongside, or as part of, extracellular …

Investigation Of A Divergent Triangle Construct For Internal Fixation Of Vertical Femoral Neck Fractures Using Experimental And Finite Element Analysis Methods, Hannah Rainey

Masters Theses

Hip fractures are a significant public health issue as they are a commonly encountered problem and have a high rate of mortality. The fracture of the femoral neck is difficult to treat due to the geometry of the proximal femur and the weight-bearing capacity that the structure must comply with. Internal fixation of the femoral neck is often accomplished with three screws inserted along the axis of the femoral neck. The optimal configuration and number of these screws is not agreed upon in the literature. The purpose of this study was to conduct a pilot investigation on the biomechanical performance …

Plant-Microbe Interactions Across Scales: Diversity, Disease, And Stress In Herbaceous Plant Communities, Philippa Tanford

Arts & Sciences Graduate Student Theses and Dissertations

Plants interact consequentially with microbes spanning mutualism to pathogenicity, with broader effects on large-scale plant community structure. These plant communties, in turn, shape below and aboveground microbial communities through a variety of mechanisms. However, plant diversity-microbial diversity relationships remain broadly inconsistent across environments and among different plant and microbial assemblages. In my dissertation, I work to bridge some of these gaps in plant-microbial ecology in three experimental chapters assessing relationships between plant diversity and microbial diversity, including the influence of belowground-aboveground microbiome interactions, the influence of drought stress, and incorporating different spatial and experimental scales. First, I explore the microbial …