Digital Commons Network^™

Reassembly Of Non-Circulized Genomes And Scientific Search For Species-Specific Primers 16s Rrna, Sijibomi Kolawole

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Observing The Effects Of P75ntr On Dopaminergic Innervation Of The Striatum And Astocyte Physiology In Parkinson's Disease Mouse Model, Thomas Burch

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Whole-Genome Sequence-Based Association Analysis Of African American Individuals With Bipolar Disorder And Schizophrenia, Runjia Li, Sarah A Gagliano Taliun, Kevin Liao, Matthew Flickinger, Janet L Sobell, Giulio Genovese, Adam E Locke, Rebeca Rothwell Chiu, Jonathon Lefaive, Jiongming Wang, Taylor Martins, Sinéad Chapman, Anna Neumann, Robert E Handsaker, Donna K Arnett, Kathleen C Barnes, Eric Boerwinkle, David Braff, Brian E Cade, Myriam Fornage, Richard A Gibbs, Karin F Hoth, Lifang Hou, Charles Kooperberg, Ruth J F Loos, Ginger A Metcalf, Courtney G Montgomery, Alanna C Morrison, Zhaohui S Qin, Susan Redline, Alexander P Reiner, Stephen S Rich, Jerome I Rotter, Kent D Taylor, Karine A Viaud-Martinez, Tim B Bigdeli, Stacey Gabriel, Sebastian Zollner, Albert V Smith, Goncalo Abecasis, Steve A Mccarroll, Michele T Pato, Carlos N Pato, Michael Boehnke, James Knowles, Hyun Min Kang, Roel A Ophoff, Jason Ernst, Laura J Scott

Faculty, Staff and Student Publications

In studies of individuals of primarily European genetic ancestry, common and low-frequency variants and rare coding variants have been found to be associated with the risk of bipolar disorder (BD) and schizophrenia (SZ). However, less is known for individuals of other genetic ancestries or the role of rare non-coding variants in BD and SZ risk. We performed whole-genome sequencing (∼27X) of African American individuals: 1,598 with BD, 3,295 with SZ, and 2,651 unaffected controls (InPSYght study). We increased power by incorporating 14,812 jointly called psychiatrically unscreened ancestry-matched controls from the Trans-Omics for Precision Medicine (TOPMed) Program for a total of …

Umi Matsuzaki’S Representation Of War Trauma: A Semiotic Approach To Studio Ghibli’S From Up On Poppy Hill, Wedhowerti Wedhowerti

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

Japanese films that explore war trauma are relatively rare, and this research departs from that gap by analyzing Studio Ghibli’s From Up on Poppy Hill. The film reflects the conscience of Japanese society by depicting the realities of post-war life in the 1960s. Using a qualitative descriptive approach, this study examines how the main character, Umi Matsuzaki, represents war trauma through eight selected scenes and how such trauma encodes myth. By applying Roland Barthes’ semiotic theory, the findings reveal that Umi embodies symptoms of post-traumatic stress disorder (PTSD), manifested primarily through avoidance and intrusion. Her trauma is deeply rooted …

Gambaran Faktor Risiko Waktu Terapi Radiasi Yang Berkepanjangan Pada Pasein Kanker Payudara: Studi Cross-Sectional Di Rsup Dr. Kariadi Tahun 2023, Zahra Zetira Muchtar, Asri C. Adisasmita, Dion Firli Bramantyo

Jurnal Epidemiologi Kesehatan Indonesia

In Indonesia, there were more than 58,000 new breast cancer cases with nearly 23,000 deaths in 2020. Radiotherapy is one of the adjuvant therapy modalities for breast cancer. Interruptions of more than five days increase the risk of local recurrence. This study aimed to describe the risk factors associated with prolonged overall treatment time (OTT) in breast cancer patients at Dr. Kariadi General Hospital during 2023. This was a cross-sectional study using bivariate logistic regression analysis to examine the association between national holidays, deterioration of general condition, age, residence, and type of surgery prior to radiation therapy with prolonged OTT. …

Kekerasan Terhadap Perempuan Dalam Cerpen “Penguburan Kembali Sitaresmi”, “Jemari Kiri”, Dan “Leteh”: Kajian Interseksionalitas, Rudi Ekasiswanto

Paradigma: Jurnal Kajian Budaya

This research discusses the typology of violence in the short stories “Penguburan Kembali Sitaresmi”, “Jemari Nayla”, and “Leteh” by using Johan Galtung’s concept. The analysis also employs an intersectional approach to reveal the social categories that enable violence and to compare the violence across the three short stories. This research shows several findings. Firstly, in the first short story, direct violence (murder) and structural violence (marginalization) occur. In the second story, there is direct violence (sexual harassment) and structural violence (marginalization). In the third story, structural violence (stigmatization) is prevalent. Secondly, all three stories depict violence against women, but they …

Factors Associated With Erectile Dysfunction In Men With Lower Urinary Tract Symptoms (Luts): A Symptoms Of Lower Urinary Tract Dysfunction Research Network (Lurn) Study, Devin Boehm, Abigail R. Smith, Sarah A. Mansfield, Kathryn E. Flynn, Richard J. Fantus, Alexander P. Glaser, Brian T. Helfand, Margaret Helmuth, Tara N. Morgan, H. Henry Lai, Aruna V. Sarma, Claire C. Yang, Ziya Kirkali, James W. Griffith

2020-Current year OA Pubs

BACKGROUND: Erectile function (EF) and its associated covariates have not been extensively studied in a large covariate of patients seeking treatment for lower urinary tract symptoms (LUTS). Our objective is to determine the relationship between urinary symptoms and comorbidities with erectile dysfunction (ED) in 447 treatment-seeking men with LUTS.

METHODS: Data from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) observational cohort study were analyzed using multivariable logistic regression models to quantify the relationship between LUTS and ED. Models also included anxiety, depression, obesity, cardiovascular disease (CVD), diabetes, and medication use.

RESULTS: Men reporting sexual activity were younger …

Longitudinal Meta-Cohort Study Protocol Using Systems Biology To Identify Vaccine Safety Biomarkers, Joann Diray-Arce, Ana C Chang, Sara Moradipoor, Donato Amodio, Bruce Carleton, Wan-Chun Chang, Nigel W Crawford, Meagan Karoly, Annmarie Hoch, Kerry Mcenaney, Tahir S Kafil, Mahitha Donthireddy, Sarah K Steltz, Simon D Van Haren, Asimenia Angelidou, Kinga K Smolen, Hanno Steen, Jessica Lasky-Su, Huyen Tran, Peter Liu, C Buddy Creech, Clare L Cutland, Helen Petousis-Harris, Ishac Nazy, Rae S M Yeung, Sonali Kochhar, Steve Black, Nicholas Wood, Dale Nordenberg, Paolo Palma, Inna G Ovsyannikova, Richard B Kennedy, Gregory A Poland, Al Ozonoff, Robert T Chen, Ofer Levy, Karina A Top, International Network Of Special Immunization Services (Insis) Members

Faculty, Staff and Students Publications

The International Network of Special Immunization Services (INSIS) was established to investigate the causes and risk factors of rare adverse events following immunizations (AEFIs) and develop immunization strategies for mitigating or preventing risk for individuals with prior AEFIs or at risk of AEFIs. INSIS integrates clinical data with multi-omic technologies (e.g., transcriptomics, proteomics, metabolomics) through a global consortium of clinical networks, leading immunology, pharmacogenomics teams to uncover the molecular mechanisms behind AEFIs. The network ensures accurate and standardized data collection and analysis through rigorous data management and quality assurance processes. INSIS also implements harmonized case definitions and protocols for collecting …

Dismantling The Established Matrix Of Power In Matrimony: A Study Of Feminine Power And Subversion In My Feudal Lord, Asia Saeed, H.M.Zahid Iqbal

Khazar Journal of Humanities and Social Sciences

This research aims to highlight the phenomenon of dismantling power dynamics in matrimonial relationships and how Pakistani women are exerting their feminine power to subvert the patriarchal system. Power and oppression are inseparable and play significant roles in shaping individuals' lives and lived experiences. The findings of this study highlight that Durrani's work has explored the dual standards of the society where patriarchal control over the marriage institution is stronger than that of women, where women always pay a huge toll for making their marriages a success. This study analyzes Tehmina Durrani's memoir ``My Feudal Lord (1995) to determine …

Effect Of Garcinol Against Arsenic-Induced Neurobehavioral Alterations And Liver And Kidney Dysfunction In Albino Mice, Abdulmohsen I. Algefare

BioMedicine

The extended exposure to inorganic arsenic is commonly linked to brain damage through oxidative and apoptotic processes. The compound known as Garcinol (GCL) has garnered significant interest due to its potential advantages for human well-being. Nevertheless, the ability of GCL to protect against toxicity generated by arsenic in the brain has not yet been investigated. Hence, our study aimed to examine the neuroprotective effectiveness of GCL in mitigating the detrimental impacts of sodium arsenite (SA) on behavioral patterns, the molecular mechanisms, apoptotic markers, and oxidative stress parameters in the brain, liver, and kidney of mice. The mice were categorized into …

Investigating The Association Between Hyperthyroidism And The Risk Of Herpes Zoster In A Cohort Study In Taiwan, Shih-Wei Lai, Yu-Hung Kuo, Kuan-Fu Liao

BioMedicine

Background: The aim of this cohort study was to investigate the association between hyperthyroidism and the likelihood of developing herpes zoster in Taiwan.

Methods: Using the National Health Insurance Research Database (NHIRD) in Taiwan, we selected individuals aged 20-84 who were newly diagnosed with hyperthyroidism between 2013 and 2020 as the hyperthyroidism group. These individuals were then matched with a control group without hyperthyroidism in a 1:1 propensity score matching for sex, age, and baseline comorbidities. The occurrence of herpes zoster was tracked in both groups until the end of the study period or until a diagnosis of herpes zoster …

An Investigation Into The Potent Anticancer, Antimicrobial, And Anti-Inflammatory Activities Of A Punica Granatum Nanoemulgel, Ahmad M Eid, Murad Abualhasan, Yara Khaliliya, Zeina Sinan, Aya Khaliliya

BioMedicine

Purpose: The objective of this study is to formulate a nanoemulgel using Punica granatum (P. granatum) seed oil and study the antibacterial, anticancer, and anti-inflammatory properties. Methods: The process to formulate a nanoemulsion from P. granatum seed oil involved using the self-nanoemulsifying technique, with Span 80 and Tween 80 serving as the emulsifying agents. Carbopol hydrogel was combined with the nanoemulsion to produce the nanoemulgel. The particle size, polydispersity index (PDI), rheological behavior, antibacterial, cytotoxic, and anti-inflammatory properties were subsequently examined.

Results: The nanoemulsion formulation with a PDI of 0.229 and a particle size of 189.44 nm was …

Metabolomics In Cancer Detection: A Review Of Techniques, Biomarkers, And Clinical Utility, Kavitha Liegelin Bernhardt, Janita R. T. Pinto

BioMedicine

Cancer poses a significant burden on global public health, contributing to high mortality rates worldwide. Ongoing diagnostic strategies have predominantly relied on imaging techniques, histopathological examination and molecular analyses which have limitations in sensitivity, and specificity. Early cancer detection is a pivotal determinant of successful treatment and patient survival rates. Metabolomic applications involve the comprehensive analysis of metabolites to understand the metabolic profile of an organism, tissue, or cell under different conditions such as lack of oxygen in tumors. The aim of this review is to provide an extensive approach of metabolomic applications in early cancer detection and to provide …

Recent Updates On Orally Disintegrating Films Regarding Design, Characterization, And Assessment, Asmaa Abdelaziz Mohamed, Firas Aziz Rahi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Orally disintegrating films (ODFs) are a pharmaceutical dosage form that liquefies or disintegrates rapidly in the mouth without water, creating an attractive option for patients with difficulty swallowing. ODFs offer several advantages, including convenience, a faster onset of action, and enhanced patient compliance.The formulation of ODFs involves selecting suitable film-forming polymers, plasticizers, active pharmaceutical ingredients (APIs), and other excipients. Factors such as taste-masking, stability, and disintegration time are critical considerations in formulating ODFs. Characterization of Orally Disintegrating Films Characterization techniques such as thickness measurement, tensile strength testing, disintegration time determination, and surface morphology analysis are essential for assessing the physical …

Gc-Ms Analysis Of Bioactive Constituents From The Leaves Of Portulaca Afra Jacq. And Portulaca Grandiflora Hook, Sadeq S.K.Al-Taie, Noor F.M. Al-Kenane, Zaidon T. Al-Aqbi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Portulaca afra and Portulaca grandiflora are traditional medicinal that grow as ornamental plants in Iraq. The present study was conducted for GC-MS analysis of the leaves of these plants to identify possible bioactive compounds. Seventy-nine compounds were recorded in the methanolic extract in Portulaca afra and ninety-two in Portulaca grandiflora. A literature survey revealed that some compounds 4-Vinylphenol, gamma-Sitosterol, Neophytadiene, n-Hexadecanoic acid, Octadecanoic acid, Phytol, Stigmasterol and Tetradecanoic acid possess a variety of biological qualities, including antioxidant, anti-inflammatory, anti-fungal, and anti-cancer effects.

Can Coffee Combat Fatty Liver? A Review Of Emerging Evidence, Mohamed E. Abd El-Hack, Muhammad Arif, Vincenzo Tufarelli, Ayman A. Swelum

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

NAFLD (Non-alcoholic fatty liver disease) is an increasingly spread metabolic status characterized by increasing fat accumulation in the liver, obesity closely associated with it, sedentary habits and insulin resistance. Since there is currently no recognized pharmaceutical treatment, lifestyle changes continue to be the mainstay of treatment. Coffee, a globally consumed beverage rich in bioactive and useful compounds like caffeine, cafestol, kahweol, and chlorogenic acids, has emerged as a potential hepatoprotective agent. Evidence from epidemiological experiments, animal studies, and human trials suggests that regular coffee drinking may help decrease hepatic fat levels, improve antioxidant defenses, prevent inflammatory pathways, and prevent or …

Play-Based Learning: A Motive Or An Impediment? A Historical Review, Osama Al-Salahat, Dina Al-Jamal, Raed Khdair

Jordan Journal of Applied Science-Humanities Series

This study aimed to identify the most critical periods that led to the emergence of play-based learning as a language instruction tool in the modern era. Additionally, it sought to investigate the effectiveness of using this method in English language instruction. Both chronological and thematic approaches were employed to present the data. The results indicated that the use of games to enhance language learning dates back to ancient societies such as Greece and Rome. However, key pioneers in this field include John Locke, Maria Montessori, Vygotsky, and Piaget. The study also found that utilizing play-based activities to improve language learning …

Towards A Conceptual Framework For Perceived Effects Of Instagram Use On The Mental Well-Being Of Young Adults In South Africa, Tinaye Tanatswa Mushore, Tendani Mulanga Chimboza

African Conference on Information Systems and Technology

It is critical to explore the effects associated with frequent Instagram use, considering its increased use over time. Instagram features that drive frequent use of the platform remain unclear, despite subsequently leading to effects on mental well-being. Limited research provides in-depth context of the correlation between effects on mental well-being and frequent use of Instagram, particularly in the context of South Africa. This cross-sectional study explains the perceived effects of Instagram use on mental well-being, in relation to Instagram features that drive frequent use. Through qualitative thematic analysis, fifteen interviews from young adults between the ages of 18 to 24 …

Galvanizing Community, Support, Well-Being, And Self-Efficacy: Supporting Doctoral Candidates Throughout The Dissertation Writing Process, Njeri M. Pringle, Jamie L. Workman

Journal of Graduate Education Research

Recent data published by the Council of Graduate Schools indicates approximately 40% of students who begin doctoral coursework do not complete their degree. This asserts the need for graduate schools to examine ways in which they can support their doctoral student population, particularly through the dissertation writing process. The purpose of this autoethnographic study was to explore two methods of dissertation writing support: a dissertation writing group sponsored by a graduate school and independent dissertation coaching services. The article highlights key findings from each support system and provides implications for dissertation writing group facilitators, dissertation coaches, and graduate schools.

Nanosensor Communication Via Localized Cnt Resonance And Central Controller Coordination, Suma Mallapragada, Vaishnavi Sankepally

Defensive Publications Series

A system and method are disclosed for delivering information from a central controller to nanoscale sensors embedded within plant tissues and receiving information back from these sensors. The approach uses localized nanoparticles to encode binary or discrete signals, enabling remote monitoring and control of plant-associated nanoscale devices. The method preserves selective targeting of individual sensors without relying on long-range electromagnetic propagation, diffusion across large distances, or microcontrollers attached to each nanosensor. The disclosed methods cover the flow of information between the controller and nanosensors, while specific designs of proboscis-inspired delivery mechanisms or controller hardware remain open for further innovation. This …

Approximation And Parameterized Algorithms For Covering With Disks Of Two Types Of Radii, Sayan Bandyapadhyay, Eli Mitchell

Computer Science Faculty Publications and Presentations

We study the Discrete Covering with Two Types of Radii problem motivated by its application in wireless networks. In this problem, the goal is to assign either small-range high frequency or large-range low frequency to each access point, maximizing the number of users in high-frequency regions while ensuring that each user is in the range of an access point. Unlike other weighted covering problems, our problem requires satisfying two simultaneous objectives, which calls for novel approaches that leverage the underlying geometry of the problem. In our work, we present two new algorithms: the first is a polynomial-time (2.5 + ϵ)-approximation, …

Development Of Respiratory Sinus Arrhythmia In Young Infants With Autism Spectrum Disorder, Preterm Birth, And Typical Development, Jessica Bradshaw, John E. Richards, Julia Yurkovic-Harding, Eilis Mclaughlin

Faculty Publications

Respiratory sinus arrhythmia (RSA) is a key index of parasympathetic function and environmental adaptability. Lower resting RSA has been linked to preterm (PT) birth in infancy and autism spectrum disorder (ASD) in childhood, yet RSA across the first 2 years in young infants born PT or later diagnosed with ASD remains unknown. This study examined resting RSA and mean interbeat interval (IBI) development from 1 to 24 months in infants at varying ASD likelihoods, including infant siblings of children with ASD and those born PT. A longitudinal design tracked resting RSA and mean IBI in 137 infants from 1 to …

August 29, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Minutes From August 29 2025, University Senate

University Senate Minutes

Minutes from August 29 2025 University Senate Meeting

Impact Of Temperature On Larval Mortality And Performance Of The Acorn Barnacle Chthamalus Fissus In San Diego, Ca, Alberto Rivera

Theses

Rising ocean temperatures and increasingly frequent marine heatwaves threaten the physiological performance and survival of marine larvae. This study quantifies the thermal tolerance, respiration, and swimming behavior of Chthamalus fissus cyprid larvae to establish a baseline for understanding their vulnerability under future climate scenarios. Larvae were collected from the Scripps Pier in La Jolla, CA and exposed to a range of temperatures (12–50°C, dependent on the experiment) to assess oxygen consumption, mortality, and swimming speeds. Oxygen consumption rates increased significantly with temperature, peaking at 30°C, with cyprids exposed to temperatures above 26°C showing significantly higher respiration rates than those below …

Barriers To Implementing Comprehensive Sexuality Education As A Strategy To Prevent Adolescent Pregnancy In Indramayu District, Indonesia, Een Kurnaesih, Chahya Kharin Herbawani, Nelly Febriani

Kesmas

The implementation of comprehensive sexuality education (CSE) is not optimal. This qualitative study aimed to identify and contextualize barriers to CSE implementation, specifically in Indramayu District, Indonesia. Conventional content analysis procedures were used. Seven participants, consisting of relevant authorities, were interviewed. A purposive sampling technique was employed to select participants. Data were collected through in-depth, semi-structured interviews. All interviews were recorded and transcribed verbatim. Data were analyzed using conventional qualitative content analysis. The barriers to CSE implementation in Indramayu District were identified across five themes: advocacy, technical considerations, coordination and collaboration, integration with other sexual and reproductive health projects, and …

Sociohydrodynamics: Data-Driven Modeling Of Social Behavior, Daniel S. Seara, Jonathan Colen, Michel Fruchart, Yael Avni, David G. Martin, Vincenzo Vitelli

Data Science Faculty Publications

Living systems display complex behaviors driven by physical forces as well as decision-making. Hydrodynamic theories hold promise for simplified universal descriptions of socially generated collective behaviors. However, the construction of such theories is often divorced from the data they should describe. Here, we develop and apply a data-driven pipeline that links micromotives to macrobehavior by augmenting hydrodynamics with individual preferences that guide motion. We illustrate this pipeline on a case study of residential dynamics in the United States, for which census and sociological data are available. Guided by Census data, sociological surveys, and neural network analysis, we systematically assess standard …

Examining Home Confinement Of Offenders In The Mississippi Delta, Malcolm Davis

Walden Dissertations and Doctoral Studies

Recidivism was identified as a persistent problem in the criminal justice system. Accordingly, prison overcrowding was also an identified problem in the prison system. The purpose of this study was to examine the experiences of home confinement for offenders in the Mississippi Delta. This research used rehabilitation theory to conduct a qualitative analysis of home confinement in the Mississippi Delta, as well as identify any unique challenges to the program presented by rural conditions. A purposive sampling technique was used to solicit participation, and a total of 12 participants were included in the study. The participants were interviewed using a …

Dynamics And Malleability Of Plant Dna Methylation During Abiotic Stresses, Niraj Lodhi, Rakesh Srivastava

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Epigenetic regulation, particularly DNA methylation, plays a crucial role in plant adaptation to environmental stresses by modulating gene expression without altering the underlying DNA sequence. In response to major abiotic stresses such as salinity, drought, heat, cold, and heavy metal toxicity, plants undergo dynamic changes in DNA methylation patterns. These modifications are orchestrated by DNA methyltransferases and demethylases with variations depending on plant species, genetic background, and ontogenic phase. DNA methylation affects the expression of key genes involved in cellular, physiological, and metabolic processes essential for stress tolerance. Furthermore, it contributes to the establishment of stress memory, which can be …

Awake And Alive: An Investigation Into Content For A Music Course Incorporating The Sciences, Harrison Boraas

Masters Theses

The purpose of this qualitative, instrumental case study was to identify the content for an interdisciplinary course about music and the brain that educates collegiate students about the benefits of lifelong music engagement. Despite increasing awareness of musical relevance to the human brain, many institutions of higher learning continue to teach music as its isolated area of study without connecting it to other fields that could benefit from incorporating it or vice versa. The sample size consisted of four to seven experts that were either community experts or Liberty University faculty in the fields of science, medicine, or music within …