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Design And Development Of A Standalone Digital Holographic Microscope Employing Phase-Driven Reconstruction And Classification For Biomedical Imaging And Optical Diagnostics, Charlotte Kyeremah

Graduate Doctoral Dissertations

Access to advanced biomedical imaging technologies remains a significant challenge in resource-limited settings, especially for early disease detection and monitoring of diseases such as malaria, HIV, and other blood-borne diseases. Although point-of-care (POC) devices have gained popularity in global health, many rely on antibody-based tests, lateral flow strips, or optical readouts that often lack quantitative capabilities, sensitivity to early infections, or versatility in different diagnostic targets. In addition, these systems are typically dependent on disposable reagents or manual interpretation, which limits their effectiveness in remote areas. Digital Holographic Microscopy (DHM) presents a promising alternative as a label-free imaging method capable …

Low-Cost Cutaneous Protoporphyrin Ix (Ppix) Detection (Cpd) Device For Follow-Up Monitoring Of Patients After Photodynamic Therapy, Md Asaduzzaman Rasel

Graduate Masters Theses

Background: Photodynamic Therapy (PDT) utilizes specific wavelengths of light to activate photosensitizing chemical compounds, known as photosensitizers, which induce the generation of cytotoxic reactive oxygen species (ROS) for the targeted destruction of cancer cells. Among various photosensitizers for PDT, Protoporphyrin IX (PpIX) is widely employed in oncology and dermatology due to its natural in situ generation via the metabolic conversion of 5- aminolevulinic acid (ALA), a non-phototoxic prodrug. Systemic administration of ALA after 3-6 hr drug delay leads to peak PpIX accumulation in tissues, facilitating therapeutic and diagnostic applications. However, PpIX can persist in the skin for 24–48 hours post-treatment, …

Sugar: A Sequence Unfolding Based Transformer Model For Group Activity Recognition, Yash U. Gondkar

Graduate Masters Theses

Large Language Models have improved significantly in the past couple of years due to the adoption of transformers. However, transformers still find it challenging to process videos due to limited context size caused by their quadratic computing cost. Therefore, we studied a booming field in machine learning which powers applications like social scene analysis and video surveillance systems called Group Activity Recognition (GAR). We found that recent models were able to achieve more than 90% accuracy on popular datasets like the Volleyball dataset, however, it turned out that even they relied on transformers.

Therefore, in this work, we developed a …

On Being The Only: Using Black Feminist Thought And Hermeneutic Phenomenology To Deeply Understand Onliness As Experienced By Black Women In Stem, Karen M. Jarvis-Thorne, Karen M. Jarvis-Thorne

Graduate Doctoral Dissertations

When a Black woman persists in a STEM undergraduate academic space as the only Black woman in that space, how is she shaped as a human being? How does she fare? How does the experience influence her decision making as she contemplates graduate school applications? Does the experience guide her decision to stay or leave STEM? In this study, the author used Black Feminist Thought to provide cultural and critical oversight of her engagement with Hermeneutic Phenomenology. Hermeneutic Phenomenology requires this oversight because the methodology’s theoretical foundations are grounded in Heidegger’s Nazism and should be critiqued if and when appropriate …

Multimodal Learning In Real-World Application: Enhancing Feature Representation And Training Strategies, Nana Lin

Graduate Doctoral Dissertations

Multimodal learning has emerged as a critical paradigm for developing intelligent systems that can understand and reason across diverse inputs such as images, text, and audio data. Despite significant advances, effective deployment of multimodal models in practice remains a challenging task. This dissertation explores how multimodal learning can be effectively applied to high-stakes, real-world scenarios, with a focus on enhancing feature representation and training efficiency. Specifically, this research investigates multimodal learning strategies in two key domains: healthcare and surveillance.

In the healthcare domain, we explored the data fusion and alignment approaches for cognitive decline diagnoses. First, we propose the LOVEMA …

The Association Between Irregular Sleep Patterns And Learning Outcomes: Implications For Students’ Health In Iraq, Hazhmat Ali, Dildar Haji Musa, Ary Habeeb Mohammed, Hiwa Abdulraheem, Sherzad Salahadeen, Alind Mustafa

Makara Journal of Health Research

Background: Students often exhibit irregular sleep patterns due to rigorous academic workloads, which exert a considerable negative impact on their mental health. The present study aims to investigate the influence of irregular sleep on academic performance.

Methods: This study recruited a cohort of 409 medical students of both genders. Upon their consent, participants filled out a closed-ended questionnaire on various sleep parameters, including sleep habits, duration, and environment.

Results: Students with irregular sleep patterns reported higher rates of sleep deprivation, late sleep onset, and troubled sleep. Moreover, they spent a longer duration using smart devices before bedtime …

Cooling Protocols Impact On Nickel-Titanium Rotary Instruments Cyclic Fatigue Resistance Under Extreme Curvatures And Sodium Hypochlorite, Palak Ravjibhai Ranparia, Chintan Joshi, Mona Somani, Aashray Patel, Urooj Desai, Janki Prajapati

Journal of Dentistry Indonesia

Objective: In this work, Hyflex CM, TruNatomy, and Plex V heat-treated nickel titanium rotary instruments were evaluated at body temperature (36 °C ± 1 °C) with and without a cooling protocol to assess the cyclic fatigue resistance. Methods: A 90° curved stainless-steel block was used for cyclic fatigue tests on 60 randomly selected rotary instruments, divided into two groups of 30: body temperature (n = 10) and body temperature with cooling (n = 10). Instruments were further subdivided into 6 groups of 3 different instruments. Cooling protocol group instruments received 5-second spray cooling every 30 seconds, along with continuous 5% …

Development And Comparative Evaluation Of A Novel Aloe Vera–Vinegar Gel As A Sustainable Histological Slide Coating Agent, Jayagopi Deepasakthi, Palati Sinduja

Journal of Dentistry Indonesia

Objective: Reliable tissue adhesion to glass slides is critical for accurate histological evaluation. Egg albumen, a commonly used coating agent, often results in background staining and inconsistent performance. Aloe vera, known for its biocompatibility and adhesive properties, presents a sustainable alternative. This study aimed to develop a novel aloe vera–vinegar gel formulation and compare its slide-coating performance with that of traditional egg albumen. Methods: Fresh Aloe vera gel was extracted and combined with nonfruit vinegar, filtered, and refrigerated. Thirty paraffin-embedded tissue sections were divided into two groups: one coated with aloe vera–vinegar gel and the other coated …

Self-Medication Behavior Of Dental Students With Oral Ulceration Lesions: A Cross-Sectional Study In Yogyakarta, Indonesia, Fita Fathaya Iriana, Hendri Susanto, Rosa Amalia

Journal of Dentistry Indonesia

Objective: Self-medication refers to medication behavior for self-diagnosed symptoms. Oral ulcers are self-medicated lesions in the oral cavity. Dental students have different knowledge about oral cavity lesions and may self-medicate using drugs. This study aimed to determine the self-medication behavior of dental students for oral ulcers. Methods: This cross-sectional study was conducted on dental students in the Faculty of Dentistry from different batch years. Purposive sampling was used to select students with oral ulcer lesions in the last six months. A validated and reliable questionnaire was used to assess self-medication behavior. Data collection using the online form. Student behavior …

Perception Of Conventional Cigarettes And Vaping Among Smokers And Nonsmokers: A Cross-Sectional Study, Indrayadi Gunardi, Rahmi Amtha, Firstine Kelsi Hartanto, Niko Falatehan, Alyah Heriandi, Angelita Victoria Kurniawan, Najla Nadiah, Wiwiek Poedjiastoeti, Andrijanto Andrijanto, Elizabeth Fitriana Sari

Journal of Dentistry Indonesia

Objectives: The growing popularity of vaping has introduced additional challenges, as potential health risks are still under investigation. Exploring differences in smoking perceptions between smokers and non-smokers could provide valuable insights into smoking behavior and inform effective intervention strategies. This study aimed to evaluate and compare the perceptions of smoking, specifically vaping and conventional cigarette use, among young adult smokers and non-smokers. Methods: An analytical cross-sectional design was employed, with 542 university students included through random sampling, using a questionnaire consisting of 8 items. Data were analyzed using the Kruskal-Wallis test and Rasch model analysis. Results: Of the subjects, 259 …

Neutral Zone Vs. Conventional Denture Fabrication: A Randomized Crossover Study On Denture Performance, Karthik Kannaiyan, Arunima Chauhan, Vijayendranath Nayak, Riyshmaa Devendaran, Dashmita Peterson, Pavittra Kanesan, Vityaa Lakshmi

Journal of Dentistry Indonesia

Objectives: It is challenging to achieve satisfactory outcomes in a complete denture for patients with resorbed residual ridges. Utilization of neutral zone techniques to guide posterior denture tooth arrangement and denture base contouring has been considered for many decades. However, the evidence is still not enough to revise protocols. This study aimed to compare patient satisfaction and stability of neutral zone denture with conventional denture. Methods: A crossover clinical trial was conducted among patients with resorbed mandibular ridges. Each participant received two sets of dentures: one fabricated using the neutral zone technique and one using the conventional method, in a …

Papillon–Lefèvre Syndrome: A Report Of Four Cases In One Family, Muhammed Abdullah Çege, Dilek Aynur Çankal, Ebru Binici, Bilge Turhan Bal

Journal of Dentistry Indonesia

Papillon–Lefèvre syndrome (PLS) is a rare genetic disorder caused by mutations in the cathepsin C gene and inherited in an autosomal recessive pattern. The risk of its occurrence is heightened by consanguineous marriages. PLS affects both genders and presents with hyperkeratotic patches on the hands and feet and precocious aggressive periodontitis. Although teeth initially erupt normally, rapid resorption in periodontal tissues leads to swift tooth loss, and prosthetic rehabilitation is complicated due to aggressive alveolar bone resorption. Case report: In 2021, a brother and sister sought dental treatment at Gazi University’s Faculty of Dentistry. After thorough examinations, the brother underwent …

Comparison Of Pharyngeal Airway And Dentoskeletal Effects Of 2 And 4 Premolar Extraction Treatment In Adult Orthodontic Patients, Esra Genc, Ahmet Karaman

Journal of Dentistry Indonesia

Objective: This study aimed to compare pharyngeal airway and dentoskeletal effects of 2 and 4 premolar extraction treatments in adult patients separately for each gender. Methods: The study was conducted with 60 adults (26 males; 34 females) aged 18-35 years. Individuals were divided into 3 groups as non-extraction, 2-premolar extraction, and 4-premolar extraction. Pre-treatment (T0) and post-treatment (T1) dentoskeletal and pharyngeal airway measurements were performed on cephalometric radiographs. Results: A significant increase in nasopharyngeal airway (PNS-ad2) and anterior hyoid bone movement (CV3ai-H) was observed in the 4-extraction group; whereas in the 2-extraction group, inferior oropharyngeal airway (IAS) narrowing and hyoid …

Biomarkers For The Diagnosis Of Indeterminate Pulmonary Nodules: Are We There Yet?, Kevin C Mcgann, Timothy A Khalil, Michael N Kammer, Edwin J Ostrin, Harvey I Pass, Jun-Chieh James Tsay, Leopoldo N Segal, Melissa Potter, Stephen A Deppen, Fabien Maldonado, Eric L Grogan

Faculty, Staff and Student Publications

Indeterminate pulmonary nodules (IPNs), which are nodules that cannot be classified as definitively benign or malignant at the time of detection, are now diagnosed on the order of millions per year. Management of IPNs remains heavily debated, and routine practice ultimately involves some balance of overall clinical risk assessment and additional diagnostic tests or procedures which may generate significant risk, cost, and worry. Biomarkers are biologically based tests or indicators capable of accurately characterizing the physiologic properties of homeostasis and disease that are not otherwise easily evaluated by the clinician. Accurate biomarkers thereby serve as reliable surrogates for biological aberrancy, …

Expression Graph Network Framework For Biomarker Discovery, Yang Liu, Jason Huse, Kasthuri Kannan

Faculty, Staff and Student Publications

Biomarker discovery for complex diseases, such as cancer, hinges on uncovering molecular signatures that capture intricate, interconnected relationships within biological data-a challenge that traditional statistical and machine learning methods often fail to meet due to the complexity of high-dimensional gene expression profiles. To overcome this, we introduce the expression graph network framework (EGNF). This cutting-edge graph-based approach integrates graph neural networks with network-based feature engineering to enhance the predictive identification of biomarkers. EGNF constructs biologically informed networks by combining gene expression data and clinical attributes within a graph database, utilizing hierarchical clustering to generate dynamic, patient-specific representations of molecular interactions. …

Auprc: A Metric For Evaluating The Performance Of In-Silico Perturbation Methods In Identifying Differentially Expressed Genes, Hongxu Zhu, Amir Asiaee, Leila Azinfar, Jun Li, Han Liang, Ehsan Irajizad, Kim-Anh Do, James P Long

Faculty, Staff and Student Publications

In silico perturbation models, computational methods that can predict cellular responses to perturbations, present an opportunity to reduce the need for costly and time-intensive in vitro experiments. Many recently proposed models predict high-dimensional cellular responses, such as gene or protein expression to perturbations such as gene knockout or drugs. However, evaluating in silico performance has largely relied on metrics such as $R^{2}$, which assess overall prediction accuracy but fail to capture biologically significant outcomes like the identification of differentially expressed (DE) genes. In this study, we present a novel evaluation framework that introduces the AUPRC metric to assess the precision …

Braingenebot: A Framework For Variant Prioritization And Generative Pretrained Transformer-Informed Interpretation Across Polygenic Risk Score Studies, Gang Qu, Nitesh Enduru, Xinyi Liu, Xiaoqian Jiang, Zhongming Zhao

Faculty, Staff and Student Publications

Polygenic risk scores (PRS) are widely used to assess genetic susceptibility in Alzheimer's disease (AD) research. However, the rapid expansion of PRS studies has led to dataset-specific biases-stemming from factors like population makeup, genotyping methods, and analysis pipelines-that result in inconsistent variant prioritization and limit generalizability and reproducibility. To address these challenges, we propose a transductive learning framework that integrates multiple PRS datasets for more robust risk variant prioritization, incorporating genome-wide association study (GWAS) priority scores as biologically informed priors. Additionally, we introduce BrainGeneBot, an AI-driven tool leveraging generative pretrained transformers with retrieval-augmented generation technology to streamline genomic analyses in …

Developing An Instrument To Measure Teacher Attitudes Toward Multilingual Pedagogies, Lauren H. Ramers

Dissertations

In an increasingly globalized world, substantial numbers of multilingual learners occupy K–12 and higher education spaces bringing diverse linguistic resources that, when intentionally and appropriately leveraged, can significantly enhance English language learning outcomes. Multilingual pedagogies, which honor and build upon students' full linguistic repertoires, are essential for fostering equitable and inclusive learning environments. This quantitative exploratory study investigated teachers' attitudes toward multilingual teaching with the goal of developing a reliable survey instrument—the Multilingual Pedagogy Scale (MPS)—to measure how teachers perceive language learning in multilingual classrooms and what they report doing in their classrooms.

First, a review of the research helped …

Characterizing Fish Communities Using Traditional And Emerging Monitoring Approaches In San Diego County Estuaries, Natalie Katherine De Wet

Theses

Fish communities are essential to estuarine health, playing key roles in food webs, nutrient cycling, and ecosystem functioning. However, the persistence of native fish populations is increasingly threatened by the cumulative impacts of coastal development, pollution, and climate change. Rapid, effective monitoring of species distributions is a priority, enabling timely conservation and management. However, the study of any ecosystem is limited by time, resources, and the consideration that research of a system can damage the ecosystem under study.

This research aimed to characterize fish species richness and evaluate the benefits and limitations of different estuary monitoring approaches. Specifically, this study …

The Gendered Role Of Friendships For Advanced Care Planning And Health In Later Life, Zee Kee Emily Lim

Graduate Doctoral Dissertations

Friendship is becoming more pertinent to older adults because they are increasingly living with fewer family ties in later life due to changing social and demographic trends (Fiori et al., 2020; Verdery et al., 2019). However, friendships are not as extensively studied as compared to family relationships (Blieszner et al., 2019). Thus, additional research is needed to better understand the influence of friendships on health and health behaviors in later life.

This dissertation includes three studies that focus on the association between friendship and loneliness, advanced care planning, and cognitive function, examining the role of gender in these three studies, …

Effect Of Seasonal Variability In Methane Emissions And Iron Redox Chemistry At Terrestrial-Aquatic Interfaces, Hermes C. Ruiz

Master's Theses

Methane (CH₄) emissions at terrestrial–aquatic interfaces (TAIs) are significant contributors to the global carbon budget, yet the mechanisms driving methanogenesis remain poorly understood. Limited data exist on how seasonal variations and redox processes influence CH₄ fluxes in these dynamic ecosystems. This study addressed two questions: (1) How are CH₄ fluxes in riverine floodplains and adjacent hillslopes impacted by seasonal variations? (2) What roles do metal redox processes (e.g., iron (Fe)) play in regulating methanogenesis?

In-situ CH₄ flux and solid-phase Fe speciation were quantified in East River, CO, under flooded and drained conditions. Groundwater chemistry, gas flux, and soil physical properties …

Crisis Convergence, Sarah Medina Camiscoli

Northwestern University Law Review

Progressive jurists and legal scholars have called the Supreme Court’s doctrine of colorblind constitutionalism that dismantled affirmative action in Students for Fair Admissions, Inc. v. President and Fellows of Harvard (SFFA) a crisis for constitutional democracy. However, scholars have not yet tended to students, particularly students mobilized for racial justice, to understand their interpretation of this race-evasive ideology and what insights those mobilized students might offer in this pivotal moment. Given the fact that a small coalition of dissenting conservative jurists, scholars, and mobilized students—the Federalist Society—spent decades crafting the doctrine, scholarship, and resources that drive colorblind constitutionalism …

Constitutional Futurisms, Jeremiah Chin

Northwestern University Law Review

How do we reckon with the past? The Supreme Court’s recent embrace of originalism as a mode of constitutional analysis relies almost exclusively on a view of history and tradition that would bind us to an understanding of principles and ideals that legitimized the exclusion of minority voices. Cases such as New York State Pistol and Rifle Ass'n v. Bruen use flavors of originalism as a framework to define rights and governmental powers through their historical antecedents, but this broad standard of interpretation is notably absent in the Court’s recent discussions of histories and traditions of racism in the United …

Toward A Perpetual Practice Of Affirmative Action, Sheldon Bernard Lyke

Northwestern University Law Review

Despite perceptions that affirmative action is “dead” following the Supreme Court ruling in Students for Fair Admissions, Inc. v. President and Fellows of Harvard College (SFFA), this Essay argues that affirmative action remains crucial for addressing racial bias in admissions processes. This Essay examines the strict scrutiny standard, which requires that any use of race must serve a compelling government interest and be narrowly tailored to achieve that interest. Courts have interpreted the narrowly tailored prong of this standard to include a logical end point requirement, which mandates that race-conscious measures must have a clear and limited …

Atypical Dengue Fever Presentation With Severe Leukopenia: A Case Report From An Endemic Border Region, Elias Arellano Villanueva, Alhasan Asaad, Jose E. Campo Maldonado

School of Medicine Publications

Dengue virus infection is increasingly recognized in South Texas, particularly in areas bordering Mexico. Although many cases are mild and self-limiting, dengue can present with atypical features, including hematological abnormalities and bleeding, even in the absence of plasma leakage. A 22-year-old Hispanic woman presented to a hospital in South Texas with hematemesis, fever, and gastrointestinal symptoms following travel to northeastern Mexico (Monterrey, Nuevo Leon). Initial laboratory workup revealed severe leukopenia and neutropenia, mild thrombocytopenia, and elevated liver enzymes, but no evidence of plasma leakage. A bone marrow biopsy was performed due to persistent cytopenias, revealing a reactive process consistent with …

Bacterial Identification And Antibiotic Sensitivity Profiles From Captive Birds At Taipei Zoo, Younjung Chang, I-Li Liu, Jane-Fang Yu, Lih-Chiann Wang

The Thai Journal of Veterinary Medicine

Bacterial infections are common in zoo birds. They may be caused by pathogenic bacteria or opportunistic bacteria due to trauma or stress-induced immune compromise. Improper use of antibiotics contributes to the development of resistant bacteria, making treatment complicated or ineffective. However, comprehensive clinical investigations into bacterial prevalence and antibiotic susceptibility in zoo-captive birds remain limited. This study identified the bacterial species present in captive diseased birds at the zoo and conducted a 12-year analysis of their antibiotic susceptibility profiles. The specimens from 48 birds at Taipei Zoo from 2006 to 2017 were submitted to a commercial reference laboratory for bacterial …

Abiotic Factors Influencing Anuran Occupation Of Neotropical Brazilian Caves, Vinícius F. Sperandei, Willian Vaz-Silva, Tejerina-Garro L. Francisco

International Journal of Speleology

Despite increasing research on the Neotropical underground environment, anurans remain poorly understood in this habitat. It was analyzed scientific literature records of anurans in Brazilian natural caves and performed a redundancy analysis (RDA) to identify the environmental, taxonomic, geographic, geological and land-use variables that influence their cave occupancy. It was examined a total of 247 literature records, encompassing 83 species/morphospecies, which revealed distinct cave-dwelling tendencies. Some anuran species occupy caves at altitudes between 5 to 21 meters above sea level (m asl), in areas characterized by rocky outcrops and grassland. Others are associated with caves surrounded by forest, savanna, pasture …

Assessment Of The Dietary Supplements Effects On Maternal Underweight In Nigeria, Chukwuebuka Jude Chiobi, Uzoamaka Angela Chiobi, Ambrose Nnaemeka Omeje, Ikechukwu Andrew Mobosi, Michael Okike Ugwu, Nnamdi Simeon Ugwu

Kesmas

Maternal underweight continues to rise and, if not properly managed, will lead to increased mortality. This contradicts the United Nations Sustainable Development Goal of reducing maternal mortality by 2050. Therefore, this study aimed to determine the probable effect of dietary supplements on maternal underweight in Nigeria. This study employed probit estimation using the maximum likelihood technique in 2022, with the 2018 Nigeria Demographic Health Survey data as the basis for analysis. The results showed a statistically significant effect of dietary supplements on maternal underweight in Nigeria. The likelihood of dietary supplements impacting maternal underweight was approximately 0.4% lower, on average, …

The Effect Of Media Variations On L. Gasseri And L. Rhamnosus Inhibition Of Uropathegenic E. Coli (Upec), Vivian Isaacson

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Functional Ecology Of Antarctic Flora, Zoie C. Yetley

Dissertations and Theses

Antarctic mosses play foundational roles in terrestrial ecosystem processes, yet their functional ecology remains poorly understood. This study developed a novel functional trait-based framework for dominant moss species across glacier retreat gradients in the South Shetland Islands, addressing a critical gap in Antarctic bryophyte ecology. Nutrient- and water-related traits were measured for four moss species--Polytrichastrum alpinum, Bryum pseudotriquetrum, Sanionia uncinata, and Syntrichia saxicola--along with Deschampsia antarctica, across nine sites spanning early to late successional stages. Results revealed strong interspecific trait differentiation: P. alpinum exhibited conservative nutrient-use and rapid water-uptake strategies; S. uncinata and B. pseudotriquetrum …