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Articles 5491 - 5520 of 31409
Full-Text Articles in Entire DC Network
Predictors Of Outpatient Follow-Up Attendance And Subsequent Psychiatric Readmission, Sandra J. Beltran
Predictors Of Outpatient Follow-Up Attendance And Subsequent Psychiatric Readmission, Sandra J. Beltran
Theses and Dissertations
Psychiatric readmissions remain a persistent challenge in mental health care, often reflecting gaps in continuity of treatment following discharge. The Agency for Healthcare Research and Quality (2019) indicated that a key component in preventing inpatient readmission is adequate outpatient care following discharge. Moreover, early attendance in outpatient follow-up visits is associated with improved patient outcomes (Boston Medical Center, 2022). Various predictors are associated with engagement in outpatient services, such as age, medication compliance, and socioeconomic variables (Carson et al., 2014; Li et al., 2005; Marino et al., 2016; Stubbs et al., 2024).
The present study sought to determine whether psychiatric …
Parent Perspectives On Contemporary Adolescent Concerns, Allyson Worthy
Parent Perspectives On Contemporary Adolescent Concerns, Allyson Worthy
Theses and Dissertations
Adolescence is a critical developmental period that marks the transition between childhood and adulthood. Psychopathology is known to emerge during this time, in which many internalizing and externalizing disorders have their onset. The assessment of adolescent psychopathology involves use of questionnaire measures to obtain perspectives from the adolescent themselves, their parents, and their teachers. Parents have been found to be especially important informants of adolescent functioning. With new challenges that arise for present-day adolescents (e.g., social media use), parents can provide insight into the different areas that need to be evaluated when assessing domains of contemporary adolescents’ development and psychopathology. …
The Science Of Sound: Studying The Cognitive, Emotional, And Physiological Effects Of Frequency, Genre, And Music, Jett Yarborough
The Science Of Sound: Studying The Cognitive, Emotional, And Physiological Effects Of Frequency, Genre, And Music, Jett Yarborough
Senior Honors Theses
Music influences emotion, physiology, and cognition, yet little is known about how the frequency it is tuned to affects these influences. Prior research has shown that music tuned to 432 Hz can reduce stress, lower blood pressure, and improve sleep. My colleagues and I conducted two studies to investigate this. Our research found that music tuned to 432 Hz promotes a significant increase in memory retention and induces a state of focus and relaxation. These results suggest that shifting from the standard tuning frequency of 440 Hz to 432 Hz could have a profoundly positive impact on our daily lives. …
Artificial Intelligence And Medical Education (2013-2024): A Scopus-Based Bibliometric Analysis, Festus Mulakoli, Edward Misava
Artificial Intelligence And Medical Education (2013-2024): A Scopus-Based Bibliometric Analysis, Festus Mulakoli, Edward Misava
School of Nursing & Midwifery, East Africa
Background: Artificial Intelligence (AI) is transforming medical education by enabling personalised learning, adaptive feedback, simulation-based training, and automated assessments. While AI offers significant benefits, including curriculum optimisation and virtual tutoring, concerns around data privacy, access, and ethical implementation persist. Although bibliometric studies have explored AI in healthcare, comprehensive analyses of global collaboration and publication trends in AI-focused medical education remain limited. Aim: This study aims to analyse global research trends, key contributors, and thematic developments in the application of AI within medical education. Methods: A bibliometric analysis was conducted using the Scopus database. The search strategy included terms …
Characterization Of Mannosidases (Man) In Tetrahymena Thermophila Using Bioinformatics Tools, Cynthia Wen
Characterization Of Mannosidases (Man) In Tetrahymena Thermophila Using Bioinformatics Tools, Cynthia Wen
Publications and Research
Mannosidases are a type of glycoside hydrolase (glycosidase) that facilitate the hydrolysis of glycosidic bonds in mannose-containing polysaccharides and glycans, including those found in glycoproteins. Their main role is to cleave specific linkages involving D-mannose residues, effectively trimming or degrading mannose-rich oligosaccharides. These enzymes are crucial in N-glycosylation pathways, which are essential for proper protein folding, glycoprotein maturation, and the regulation of carbohydrate metabolism in eukaryotic cells.
There are two main types of mannosidases: alpha-mannosidases and beta-mannosidases. In humans, several of these enzymes exist, including those found in the endoplasmic reticulum (alpha-mannosidase I), those in the Golgi apparatus (alpha-mannosidase II), …
Program Evaluation Of Tms Treatment For Patients With Comorbid Major Depressive Disorder And Ptsd, Alec Wilson
Program Evaluation Of Tms Treatment For Patients With Comorbid Major Depressive Disorder And Ptsd, Alec Wilson
Doctor of Nursing Practice
Nearly six million in the U.S. experience symptoms associated with the diagnoses of comorbid Major Depressive Disorder (MDD) and Post Traumatic Stress Disorder (PTSD). Many with these diagnoses fail to respond to first line treatments that include medication and psychotherapy. Transcranial magnetic stimulation (TMS) therapy is a non-invasive treatment option for individuals who fail to respond to first line treatments.
Methods: This program evaluation completed a retrospective chart review of adult patients with comorbid MDD and PTSD, who received TMS treatments at a private practice clinic between the time frame of September 2024 and October of 2025.
Results: All …
47th Biennial Convention Of Sigma Gamma Epsilon, Western Illinois University, April 11–13, 2025, Richard L. Ford, Lee S. Potter
47th Biennial Convention Of Sigma Gamma Epsilon, Western Illinois University, April 11–13, 2025, Richard L. Ford, Lee S. Potter
The Compass: Earth Science Journal of Sigma Gamma Epsilon
The Society of Sigma Gamma Epsilon (SGE), the national honorary society for the Earth sciences, held its 47th biennial convention (April 11–13, 2025) at the Quad Cities campus, located in Moline, Illinois, of Western Illinois University (WIU). The convention was hosted by SGE’s Delta Psi Chapter and the Department of Earth, Atmospheric, and Geographic Information Sciences at WIU. Ten (10) of SGE’s approximately 57 active collegiate chapters sent delegates to the convention. The traditional convention field trip, an exploration of the Paleozoic stratigraphy and economic geology of the Quad Cities area of Illinois and Iowa, made stops at the Fryxell …
The Effect Of Chronic Azithromycin Use In Winter On Health Care Utilization For Children With Bronchopulmonary Dysplasia: A Double Blind Randomized Controlled Study (Rct), Ricardo A Mosquera, Aravind Yadav, Maria Del Mar Romero-Lopez, Ivan G Magana-Ceballos, S Shahrukh Hashmi, Wilfredo De Jesus Rojas, Maria E Tellez, Kaleigh Riggs-Harpur, Fatima M Boricha, Tina S Reddy, Janice L John, Tomika S Harris, Carlos E Rodriguez-Martinez, Jefferson Buendia, Katrina E Mcbeth, Cindy K Jon, James M Stark, Giuseppe N Colasurdo
The Effect Of Chronic Azithromycin Use In Winter On Health Care Utilization For Children With Bronchopulmonary Dysplasia: A Double Blind Randomized Controlled Study (Rct), Ricardo A Mosquera, Aravind Yadav, Maria Del Mar Romero-Lopez, Ivan G Magana-Ceballos, S Shahrukh Hashmi, Wilfredo De Jesus Rojas, Maria E Tellez, Kaleigh Riggs-Harpur, Fatima M Boricha, Tina S Reddy, Janice L John, Tomika S Harris, Carlos E Rodriguez-Martinez, Jefferson Buendia, Katrina E Mcbeth, Cindy K Jon, James M Stark, Giuseppe N Colasurdo
Faculty, Staff and Student Publications
Background: Bronchopulmonary dysplasia (BPD), a chronic lung disease in preterm infants, often leads to acute respiratory exacerbations triggered by infections. Our previous mouse study suggested that azithromycin's anti-inflammatory properties may benefit virus-induced respiratory illnesses prophylactically.
Methods: In this single-center, double-blind RCT, 60 children (6 months to 6 years) with BPD received azithromycin (5 mg/kg three times weekly; n = 30) or placebo (n = 30) for one winter season (October to March). Primary outcome was the total number of days of unscheduled healthcare clinic visits, ER visits, and hospital days. Secondary outcomes comprised clinic visits, ER visits, hospital admissions, hospital …
Bone Marrow Endosteum In Homeostasis And Metastasis, Yuta Nakai, Wanida Ono, Noriaki Ono
Bone Marrow Endosteum In Homeostasis And Metastasis, Yuta Nakai, Wanida Ono, Noriaki Ono
Faculty, Staff and Student Publications
The endosteum is a thin layer of connective tissue lining the inner surfaces of bones adjoining the medullary cavity. The endosteum houses a variety of cells crucial for bone growth, repair and remodelling, including bone-forming osteoblasts, bone-resorbing osteoclasts and their precursor cells. Historically, the endosteum has been extensively studied as a key site for haematopoiesis by which blood cells are incessantly produced. However, recent studies have defined the endosteum as a niche for skeletal stem cells, underscoring the importance of the harmony between the inner endosteum and the outer periosteum in maintaining bone homeostasis. The endosteum also plays a significant …
The Fear Factor: Exploring The Experiences Of Fear Of Secondary School Teachers, Kelly J. Raines
The Fear Factor: Exploring The Experiences Of Fear Of Secondary School Teachers, Kelly J. Raines
Doctor of Education (Ed.D)
Fear can be a powerful catalyst for cognitive potential, or a potent agent of havoc. This descriptive (transcendental) phenomenological study aimed to understand the phenomenon of fear experienced by teachers in public and private secondary schools in Central Florida. Semi-structured interviews collected data from the purposive sample, and the data were thoroughly analyzed using Colaizzi's (1978) model. The emergent essence of the lived experience of teachers identified the phenomenon of fear as the inducement of a debilitating sense of powerlessness that diminishes self-confidence and self-efficacy, resulting in emotional, cognitive, and/or physical impairments that directly affect the metacognitive potential of teachers. …
Supporting Youth Through Violence And Loss, Tiara Bolden
Supporting Youth Through Violence And Loss, Tiara Bolden
Selected Social Change Portfolios in Prevention, Intervention, and Consultation
Goal Statement: The goal of this prevention portfolio is to strengthen protective factors for adolescents in Richmond, Virginia, who have experienced violence or loss. The focus is on reducing emotional distress, strengthening resilience, and promoting healthy development among youth who have been affected by community trauma. Significant Findings: Youth in Richmond are disproportionately affected by poverty, violence, and exposure to loss, which contribute to high rates of depression, anxiety, and emotional distress. The City of Richmond Community Health Needs Assessment (2022) found that nearly 29% of youth live in poverty, while the Virginia Youth Risk Behavior Survey (2023) reported that …
Tutoring Online During The Covid-19 Pandemic: Use Of Critical Incidents To Improve Practice, A.E. Dreyfuss, Jose Armando Sanchez Diaz, Barakat Adigun, Helen Baraki, Thalyia Thompson
Tutoring Online During The Covid-19 Pandemic: Use Of Critical Incidents To Improve Practice, A.E. Dreyfuss, Jose Armando Sanchez Diaz, Barakat Adigun, Helen Baraki, Thalyia Thompson
Publications and Research
Developing expertise in the practice of online tutoring is presented by peer tutors who provided support to students with synchronous sessions with the onset of COVID-19. The experiences and learning of peer tutors were probed through the use of critical incidents (Flanagan, 1954), and how weekly training meetings provided support to them, creating a collaboration among the tutors and the training manager.
Penetrance Of Neurodevelopmental Copy Number Variants Is Associated With Variations In Cortical Morphology, Ana I. Silva, Ida E. Sønderby, George Kirov, Abdel Abdellaoui, Ingrid Agartz, David Ames, Nicola J. Armstrong, Eric Artiges, Tobias Banaschewski, John Blangero
Penetrance Of Neurodevelopmental Copy Number Variants Is Associated With Variations In Cortical Morphology, Ana I. Silva, Ida E. Sønderby, George Kirov, Abdel Abdellaoui, Ingrid Agartz, David Ames, Nicola J. Armstrong, Eric Artiges, Tobias Banaschewski, John Blangero
Human Genetics Publications
Background: Copy number variants (CNVs) may increase the risk for neurodevelopmental conditions. The neurobiological mechanisms that link these high-risk genetic variants to clinical phenotypes are largely unknown. An important question is whether brain abnormalities in individuals who carry CNVs are associated with their degree of penetrance.
Methods: We investigated whether increased CNV penetrance for schizophrenia and other developmental disorders was associated with variations in cortical and subcortical morphology. We pooled T1-weighted brain magnetic resonance imaging and genetic data from 22 cohorts from the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)-CNV consortium. In the main analyses, we included 9268 individuals …
Academic Department Indicators: 2024-2025, Systems Intelligence And Data Analytics, University Of Nebraska At Omaha
Academic Department Indicators: 2024-2025, Systems Intelligence And Data Analytics, University Of Nebraska At Omaha
Academic Department Indicators
The audience is the Academic Planning Council (APC), college and department heads, and faculty. The purpose is to report instructional productivity measures useful for making comparisons and observing trends. Selected departmental information in this report is submitted annually to the Delaware Study, a National Study of Instructional Costs and Productivity.
This Instructional Productivity information corresponds to the UNO state- and tuition-funded budget. The Supplemental Information at the end of the document provides counts and statistics for campus-wide programs embedded in most colleges. Only Dual Enrollment instruction is excluded from the productivity report since it is a fee-based instructional program for …
Rrad-Reduction Reveals Efficacy Of Targeting L-Type Calcium Channel Regulation For Treatment Of Heart Failure, Garrett Elmore, Sarisha S. Lohano, Nicholas M. Mcvay, Bryana M. Levitan, Andrea Sebastian, Kyle W. Barker, Alec Dupont, Steven W. Leung, Riham R.E. Abouleisa, Pretty R. Mathew, Austin Wellette-Hunsucker, Austin T. Minton, Kenneth S. Campbell, Solomon W. Harrar, Mohammad Mehri, Jonathan F. Wenk, Tamer M.A. Mohamed, Douglas A. Andres, Jonathan Satin
Rrad-Reduction Reveals Efficacy Of Targeting L-Type Calcium Channel Regulation For Treatment Of Heart Failure, Garrett Elmore, Sarisha S. Lohano, Nicholas M. Mcvay, Bryana M. Levitan, Andrea Sebastian, Kyle W. Barker, Alec Dupont, Steven W. Leung, Riham R.E. Abouleisa, Pretty R. Mathew, Austin Wellette-Hunsucker, Austin T. Minton, Kenneth S. Campbell, Solomon W. Harrar, Mohammad Mehri, Jonathan F. Wenk, Tamer M.A. Mohamed, Douglas A. Andres, Jonathan Satin
Surgery Faculty Publications
Aims Heart failure with reduced ejection fraction (HFrEF) is a major health problem. Increasing L-type calcium channel (LTCC) activity deteriorates heart function; however, myocardial RRAD knockout (cRADΔ/Δ) instills tonic modulated LTCC current (ICa,L) that preserves healthy myocardium. Thus, we chose to challenge the dogma that enhanced trigger Ca2+ is maladaptive. The study objective was to test the hypothesis that modulated ICa,L in cRADΔ/Δ mice rescues dilated cardiomyopathy by providing tonic modulated trigger Ca2+. Methods and results Mouse and human models were tested. The muscle lim protein knockout mouse (MLPKO) is a murine model of dilated cardiomyopathy (DCM) and HFrEF. The …
The Bulletin: Sidney Kimmel Medical College At Thomas Jefferson University, Volume 103, Issue 2, Fall 2025
The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)
This issue includes:
- 5 - Dean’s Column
- 6 - Time Machine
- 12 - ICYMI (In Case You Missed It)
- 18 - Medicine Rooted in Connection by Scott Orlov, SKMC Class of 2026
- 20 - All in the Family by Takami Sato, MD, PhD, and Rino Seedor, MD ’15
- 24 - When Jefferson and Medicine Struck Gold by Geno J. Merli, MD ’75, RES ’78 and ’80
- 28 - Alumni Weekend Recap
- 32 - Born a Jeffersonian by William Valentine Harrer, MD ’62
- 35 - Class Ambassadors
- 36 - A Message From the SKMC Alumni Board President
- 38 - Class Notes …
Slb-Mssim: A Spectral Library-Based Multiplex Segmented Sim Platform For Single-Cell Proteomic Analysis, Lakmini Senavirathna, Cheng Ma, Van-An Duong, Hong-Yuan Tsai, Ru Chen, Sheng Pan
Slb-Mssim: A Spectral Library-Based Multiplex Segmented Sim Platform For Single-Cell Proteomic Analysis, Lakmini Senavirathna, Cheng Ma, Van-An Duong, Hong-Yuan Tsai, Ru Chen, Sheng Pan
The Brown Foundation: Institute of Molecular Medicine
Mass spectrometry (MS)-based single-cell proteomics, while highly challenging, offers unique potential for a wide range of applications to interrogate cellular heterogeneity, trajectories, and phenotypes at a functional level. We report here the development of the spectral library-based multiplex segmented selected ion monitoring (SLB-msSIM) method, a conceptually unique approach with significantly enhanced sensitivity and robustness for single-cell analysis. The single-cell MS data is acquired by a multiplex segmented selected ion monitoring (msSIM) technique, which sequentially applies multiple isolation cycles with the quadrupole using a wide isolation window in each cycle to accumulate and store precursor ions in the C-trap for a …
Investigating Machine Learning Algorithms To Classify Label-Free Images Of Pancreatic Neuroendocrine Neoplasms, Noelle Daigle, Shuyuan Guan, Suzann Duan, Thomas G Knapp, Eung-Joo Lee, Ali Azhdarinia, Sukhen C Ghosh, Solmaz Aghaamiri, Servando Hernandez Vargas, Naruhiko Ikoma, Jeannelyn Estrella, Martin J Schnermann, Tobias Else, Michelle Kang Kim, Juanita L Merchant, Travis W Sawyer
Investigating Machine Learning Algorithms To Classify Label-Free Images Of Pancreatic Neuroendocrine Neoplasms, Noelle Daigle, Shuyuan Guan, Suzann Duan, Thomas G Knapp, Eung-Joo Lee, Ali Azhdarinia, Sukhen C Ghosh, Solmaz Aghaamiri, Servando Hernandez Vargas, Naruhiko Ikoma, Jeannelyn Estrella, Martin J Schnermann, Tobias Else, Michelle Kang Kim, Juanita L Merchant, Travis W Sawyer
The Brown Foundation: Institute of Molecular Medicine
Significance: Pancreatic neuroendocrine neoplasms (PNENs) are an uncommon cancer whose incidence rate has increased dramatically in recent years. Surgery is the only potentially curative treatment, which relies on both preoperative tumor localization and postoperative margin definition using histopathological examination for decision making. If pathology could be automated, valuable time and resources could be saved.
Aim: In this study, we investigate the ability of machine learning (ML) with handcrafted features, as well as deep learning, to classify label-free microscopy images of PNENs as a first step toward automated pathology of such tumors.
Approach: Patient samples of two different preparation types were …
Valid And Accepted Novel Bacterial Taxa Isolated From Domestic Companion And Agricultural Animals Described In 2024, Sara D. Lawhon, Claire R. Burbick, Trinity Krueger, Elena Ruiz-Reyes, Ayden Wisney-Leonard, Mallory Lenmark, Erik Munson
Valid And Accepted Novel Bacterial Taxa Isolated From Domestic Companion And Agricultural Animals Described In 2024, Sara D. Lawhon, Claire R. Burbick, Trinity Krueger, Elena Ruiz-Reyes, Ayden Wisney-Leonard, Mallory Lenmark, Erik Munson
Clinical Lab Sciences Faculty Research and Publications
Recognizing and updating bacterial names is key to communication between the veterinary clinical microbiology laboratory, veterinarians, and clients. Moraxella oculi sp. nov., distinct from Moraxella bovis and Moraxella bovoculi, was isolated from a cow with infectious bovine keratoconjunctivitis. Several respiratory pathogens were recognized, including Neisseria leonii sp. nov. described from rabbits, Mannheimia indoligenes sp. nov. described from cattle in Europe, and Moraxella haemolytica sp. nov. described from a goat in China. Stenotrophomonas forensis sp. nov. is a novel designation within the Stenotrophomonas maltophilia complex associated with isolates derived from horses. New additions to the Campylobacter genus included Campylobacter californiensis …
Aadej Comm 11 3 2025
AADEJ - The Communicator
The Communicator is the Journal of the American Association of Dental Editors. It is published quarterly and distributed digitally via email to members and posted on the Association’s website aadej.org. This issue of The Communicator features articles focused on organizational strategy, publishing ethics, and critical issues in the profession. The Editor-in-Chief announces his intention to step down, reflecting on the organization's history. The President advocates for shifting the organizational focus from individual benefits to collective sustainability ("What’s in it for us?"). Organizational updates include the restructuring of the Publication Membership to allow three voting members for the same fee and …
The Public Health Cost Of Online Behavioral Targeting, Arthi Annadurai
The Public Health Cost Of Online Behavioral Targeting, Arthi Annadurai
Vanderbilt Journal of Entertainment & Technology Law
Behavioral targeting is an increasingly popular marketing technique that utilizes users’ online activity to personalize advertisements aimed at consumers. However, since personalized advertisements aim to influence individual consumers, behavioral targeting can negatively impact vulnerable users. For instance, it may reinforce harmful behaviors—like showing alcohol advertisements to individuals with alcohol dependency—or worsen mental health struggles, such as prolonging grief by continuing to serve parenting advertisements to those mourning the loss of a child. These practices can perpetuate harmful behaviors, such as relapse or heightened psychological distress, and contribute to long-term health problems, such as addiction or other mental health problems, creating …
The Distribution Of The Number Of Mutations In The Genealogy Of A Sample From A Single Population, Yun-Xin Fu
The Distribution Of The Number Of Mutations In The Genealogy Of A Sample From A Single Population, Yun-Xin Fu
Faculty, Staff and Student Publications
The number K of mutations in the genealogy of a sample of n sequences from a single population is one essential summary statistic in molecular population genetics and is equal to the number of segregating sites in the sample under the infinite-sites model. Although its expectation and variance are the most widely utilized properties, its sampling formula (i.e., probability distribution) is the foundation for all explorations related to K. Despite existence of an analytic sampling formula, its numerical application is limited due to susceptibility to error propagation. This paper presents a new sampling formula for K in a random sample …
Sleep Eeg And Respiratory Biomarkers Of Sudden Unexpected Death In Epilepsy (Sudep): A Case-Control Study, Oman Magana-Tellez, Rama Maganti, Norma J Hupp, Xi Luo, Sandhya Rani, Johnson P Hampson, Manuela Ochoa-Urrea, Sudha S Tallavajhula, Rup K Sainju, Daniel Friedman, Maromi Nei, Brian K Gehlbach, Stephan Schuele, Ronald M Harper, Beate Diehl, Lisa M Bateman, Orrin Devinsky, George B Richerson, Samden D Lhatoo, Nuria Lacuey
Sleep Eeg And Respiratory Biomarkers Of Sudden Unexpected Death In Epilepsy (Sudep): A Case-Control Study, Oman Magana-Tellez, Rama Maganti, Norma J Hupp, Xi Luo, Sandhya Rani, Johnson P Hampson, Manuela Ochoa-Urrea, Sudha S Tallavajhula, Rup K Sainju, Daniel Friedman, Maromi Nei, Brian K Gehlbach, Stephan Schuele, Ronald M Harper, Beate Diehl, Lisa M Bateman, Orrin Devinsky, George B Richerson, Samden D Lhatoo, Nuria Lacuey
Faculty, Staff and Student Publications
Background: Sudden unexpected death in epilepsy (SUDEP) is the most common category of epilepsy-related mortality. Centrally mediated respiratory dysfunction has been observed to lead to death in the majority of cases of SUDEP. SUDEP also mainly occurs during nighttime sleep. This study seeks to identify sleep EEG and sleep-related respiratory biomarkers of SUDEP risk.
Methods: In this case-control study, we compared demographic, clinical, EEG, and respiratory data from people with epilepsy who later died of SUDEP (the SUDEP group) with data from age and sex-matched living people with epilepsy, classified as high risk of SUDEP (with ≥1 generalised tonic-clonic seizure …
Predictive Gene Expression Signatures For Alzheimer's Disease Using Post-Mortem Brain Tissue, Ashley Duche, Oliver Tan, Andrius Baskys, Rachita K. Sumbria, Moom R. Roosan
Predictive Gene Expression Signatures For Alzheimer's Disease Using Post-Mortem Brain Tissue, Ashley Duche, Oliver Tan, Andrius Baskys, Rachita K. Sumbria, Moom R. Roosan
Pharmacy Faculty Articles and Research
Background: Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques and tau protein aggregates in the brain. These pathological features manifest in specific regions, but mechanisms rendering some areas more susceptible to early AD-related changes remain poorly understood. To address this, we developed predictive gene expression signatures to explore molecular mechanisms underlying regional vulnerability to AD pathology.
Methods: Post-mortem brain tissues from participants of the Religious Orders Study and Memory and Aging Project (ROSMAP), Mayo Clinic, and Mount Sinai Brain Bank (MSBB) were used to derive gene expression signatures from six brain regions affected at varying …
Mitochondrial Haplogroups, But Not Heteroplasmy, Are Associated With Midlife Cognitive Function, Nien Yeh Daphne Yu, Shea J Andrews, Lifang Hou, Myriam Fornage, Kristine Yaffe
Mitochondrial Haplogroups, But Not Heteroplasmy, Are Associated With Midlife Cognitive Function, Nien Yeh Daphne Yu, Shea J Andrews, Lifang Hou, Myriam Fornage, Kristine Yaffe
Faculty, Staff and Student Publications
Introduction: Mitochondrial DNA (mtDNA) variation may influence cognitive performance, but prior findings are inconsistent.
Methods: We analyzed data from 2308 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study, assessing heteroplasmy (mtHz) burden and haplogroups (mtHg) from blood-derived mtDNA at three timepoints and cognitive function across multiple domains. Multivariate linear regression models and multivariate linear mixed models adjusted for age, sex, education, and race.
Results: MtDNA heteroplasmy burden and count were not associated with cognitive performance. However, mtHgs in macro-mtHg L were linked to poorer cognitive outcomes, particularly in processing speed and global cognition in cross-sectional and …
Optimization Of A Mobile Imaging System To Aid In Evaluating Patients With Oral Lesions In A Dental Care Setting, Ruchika Mitbander, Jennifer Carns, Richard A Schwarz, Sean Anderson, Geethanjali Vipulanandan, Miriam Hernandez, Amelia E Hartzell, Jun Jiao, Ilona Rutkowska, Safia Durab, Sahar Sadeghi, Ashlee D Clayton, Nancy Bass, Loganayaki Anandasivam, Rachel A Giese, Ann M Gillenwater, Nadarajah Vigneswaran, Rebecca Richards-Kortum
Optimization Of A Mobile Imaging System To Aid In Evaluating Patients With Oral Lesions In A Dental Care Setting, Ruchika Mitbander, Jennifer Carns, Richard A Schwarz, Sean Anderson, Geethanjali Vipulanandan, Miriam Hernandez, Amelia E Hartzell, Jun Jiao, Ilona Rutkowska, Safia Durab, Sahar Sadeghi, Ashlee D Clayton, Nancy Bass, Loganayaki Anandasivam, Rachel A Giese, Ann M Gillenwater, Nadarajah Vigneswaran, Rebecca Richards-Kortum
Faculty, Staff and Student Publications
Significance: Oral cancer is often diagnosed at an advanced stage even though the oral cavity is easily accessible for examination. There is a need for tools to support early detection and help non-expert clinicians make appropriate referral recommendations.
Aim: We aim to evaluate a mobile detection of oral cancer (mDOC) smartphone-based autofluorescence imaging system by collecting data in a representative, low-prevalence population and optimizing a referral algorithm suitable for deployment in community dental settings.
Approach: Data were collected from patients at a community dental clinic using the mDOC system, which captures white light and autofluorescence images. A multi-input deep learning …
Three-Dimensional Human Mucopolysaccharidosis Iva Chondrocyte Culture Reveals Significant Impairments In The Lysosomal-Mitochondrial Crosstalk, Andrés Felipe Leal, Sampurna Saikia, Shaukat A. Khan, Shunji Tomatsu
Three-Dimensional Human Mucopolysaccharidosis Iva Chondrocyte Culture Reveals Significant Impairments In The Lysosomal-Mitochondrial Crosstalk, Andrés Felipe Leal, Sampurna Saikia, Shaukat A. Khan, Shunji Tomatsu
Department of Pediatrics Faculty Papers
Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder (LSD) caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase enzyme. MPS IVA patients suffer from skeletal dysplasia due to the abnormal function of chondrocytes. Given the interactions of lysosomes with various intracellular organelles, it is not surprising that lysosomal dysfunction can lead to improper functioning of lysosome-interacting organelles such as mitochondria. Mitochondrial alterations have been evaluated in several LSDs; nevertheless, they have not been fully addressed in MPS IVA. In this study, we assessed the mitochondrial alterations in MPS IVA chondrocytes using a three-dimensional culture approach. Our findings revealed that MPS IVA …
Assessing The Effectiveness Of Bridge Grate And Pipe Cattle Guard Designed To Mitigate Ocelot Road Mortality On Texas State Highway, Rupesh Maharjan, John H. Young Jr., Kevin W. Ryer, Md. Saydur Rahman, Richard J. Kline
Assessing The Effectiveness Of Bridge Grate And Pipe Cattle Guard Designed To Mitigate Ocelot Road Mortality On Texas State Highway, Rupesh Maharjan, John H. Young Jr., Kevin W. Ryer, Md. Saydur Rahman, Richard J. Kline
School of Earth, Environmental, & Marine Sciences Faculty Publications
The mitigated and fenced section of State Highway 100, extending from Laguna Vista to Los Fresnos, includes five wildlife crossing structures and 16 modified cattle guards (also called wildlife guards) installed to mitigate ocelot road mortality. Bridge grate and pipe wildlife guards were deployed at vehicle entries, and we evaluated their effectiveness in preventing meso-carnivores and ungulates from entering the roadway through the fence gaps from April 2020 to 2024. Wildlife guards collectively were >82% effective in repelling ungulate attempts to enter the roadway, while only 16.64% of meso-carnivore attempts were repelled. The pipe wildlife guard (PWG) design repelled 86.79% …
Chemistry And Biochemistry Affiliated Publications: Snapshot Of The Research Publications 2019-2024., Jeremy J. Smith, Lutishoor Salisbury
Chemistry And Biochemistry Affiliated Publications: Snapshot Of The Research Publications 2019-2024., Jeremy J. Smith, Lutishoor Salisbury
University Libraries Faculty Publications and Presentations
This report highlights the chemistry and biochemistry faculty publications for the period 2019-2024. It includes tables identifying the types of publications, the characteristics of the authors, inter-departmental and external cooperation, summary of the citations of the publications, and the JCR ranking of the journals in which they published.
Syllabus: Ssw Field Instruction 3, Katrina Hannan
Syllabus: Ssw Field Instruction 3, Katrina Hannan
Open Educational Resources
Designed to integrate social work knowledge, skills, and values, these courses utilize ecosystems and strengths perspectives alongside a cultural competence model to develop foundational practice competencies for entry-level social work practice. As core elements of the educational program, they bridge academic learning with practical application, enabling students to apply classroom knowledge in real-world settings. The practicum experience emphasizes strategies for engaging with diverse populations, advocating for human rights, and promoting social and economic justice. This hands-on experience fosters the development of practice skills that enhance social well-being and prepare students for effective, ethical social work across micro, mezzo, and macro …