Digital Commons Network^™

The Temporal Dynamics Of Attention To Threat And Gad Symptoms: A Study Of Lpp Slopes, Ben Swanson, Matt R. Judah, Grant S. Shields

Psychological Science Faculty Publications and Presentations

Individuals experiencing generalized anxiety disorder (GAD) show heightened attention to threat, as suggested by greater amplitude of the late positive potential (LPP). However, amplitude measurements do not fully capitalize on the high temporal resolution of EEG. Specifically, amplitude does not reflect the rate of change in the LPP over a window of interest, which may be important to understand LPP dynamics in individuals with GAD. Indeed, this rate of change of the LPP (i.e., LPP slope) may reflect attentional orienting. The current study leveraged multilevel models to examine the LPP in relation to GAD symptoms. We hypothesized that more-positive LPP …

Molecular Dynamics Of The Host Response To Streptococcus Pneumoniae Pneumonia In Baboons, Bryan D Kraft, Et Al.

2020-Current year OA Pubs

BACKGROUND: Bacterial pneumonia remains a leading cause of morbidity and mortality worldwide despite the widespread availability of antibiotics. Novel pneumonia therapies and biomarkers are urgently needed to improve outcomes and advance personalized therapy. Using an established baboon model of S. pneumoniae pneumonia, we sought to characterize the temporal dynamics of pneumonia host responses to identify novel potential diagnostic and therapeutic molecular targets.

METHODS: We performed whole blood transcriptomics, unbiased proteomics, and peripheral cytokine measurements serially in baboons inoculated with S. pneumoniae (n = 23) or saline (n = 10) and modeled the peripheral blood host response using principal components analysis …

Chimeric Antigen Receptor Natural Killer (Car-Nk) Cells: From Preclinical Promise To Clinical Reality In Cancer Immunotherapy, Hunter Cassidy Cochran, Kevin Ashkan Ghobadi, Armin Ghobadi

2020-Current year OA Pubs

Chimeric antigen receptor (CAR) natural killer (NK) cell therapy represents an emerging frontier in cancer immunotherapy. CAR-NK cells offer the potential for "off-the-shelf" treatments with a favorable safety profile, due in part to their innate capacity for HLA-unrestricted tumor targeting and an absence of graft-versus-host disease. Landmark clinical studies using cord blood - derived CAR-NK cells and another employing iPSC-derived CAR-NK cells have reported impressive response rates, durable remissions, and minimal toxicity. Furthermore, a growing landscape of ongoing clinical trials is exploring innovative strategies to enhance persistence, overcome solid tumor challenges, and prevent antigen escape. These advances collectively underscore the …

Recent Advances In The Identification And Quantification Of Xylazine And Medetomidine In Biological Specimens, Bridgit O Crews

2020-Current year OA Pubs

Xylazine is a veterinary sedative that is frequently detected in the illicit drug supply, often found mixed with illicitly manufactured fentanyl (IMF). It has been detected in the blood of overdose victims and patients who use illicit drugs. Xylazine is not approved for use in humans. It is an alpha-2-adrenergic receptor agonist that causes deep sedation that is non-responsive to naloxone, the antidote for opioid overdose. Chronic exposure to xylazine has been linked to severe wounds that can progress to amputation. Medetomidine is another related veterinary sedative that has more recently emerged as an adulterant in IMF. Medetomidine is also …

Family Income And Polygenic Scores Are Independently But Not Interactively Associated With Cognitive Performance Among Youth Genetically Similar To European Reference Populations, S E Paul, N M Elsayed, S M C Colbert, R Bogdan, A S Hatoum, D M Barch

2020-Current year OA Pubs

Cognitive abilities are heritable and influenced by socioeconomic status (SES). It is critical to understand the association between SES and cognition beyond genetic propensity to inform potential benefits of SES-based interventions and to determine if such associations vary across (i) cognitive domains, (ii) facets of SES, and/or (iii) genetic propensity for different aspects of cognition. We examined the contributions of neighborhood socioeconomic advantage, family income, and polygenic scores (PGS) for domains of cognition (i.e., general cognitive ability, executive function, learning and memory, fluid reasoning) in a sample of children (ages 9-10;

Hcmv Infection Of Terminally Differentiated Neurons Disrupts Microtubule Organization, Resulting In Neurite Retraction, Jacob W. Adelman, Andrew T. Sukowaty, Kaitlyn J. Partridge, Jessica E. Gawrys, Allison Akins, Scott S. Terhune, Allison D. Ebert

Biological Sciences Faculty Research and Publications

Human cytomegalovirus (HCMV) is a prolific human herpesvirus that infects most individuals by adulthood. While typically asymptomatic in adults, congenital infection can induce serious neurological symptoms, including hearing loss, visual deficits, cognitive impairment, and microcephaly in 10%–15% of cases. HCMV has been shown to infect most neural cells, with our group recently demonstrating this capacity in stem cell-derived forebrain neurons. Infection of neurons induces deleterious effects on calcium dynamics and electrophysiological function paired with gross restructuring of neuronal morphology. Here, we utilize an induced pluripotent stem cell-derived model of the human forebrain to demonstrate how HCMV infection induces syncytia, drives …

Microglia Regulate Gabaergic Neurogenesis In Prenatal Human Brain Through Igf1, Diankun Yu, Samhita Jain, Andi Wangzhou, Beika Zhu, Wenyuan Shao, Elena J Coley-O'Rourke, Stacy De Florencio, Jaeyeon Kim, Jennifer Ja-Yoon Choi, Mercedes F Paredes, Tomasz J Nowakowski, Eric J Huang, Xianhua Piao

2020-Current year OA Pubs

GABAergic neurons are essential cellular components of neural circuits. Their abundance and diversity have increased significantly in the human brain, contributing to the expanded cognitive capacity of humans

Spatial Multiomics Of Acute Myocardial Infarction Reveals Immune Cell Infiltration Through The Endocardium, Florian Wünnemann, Junedh M Amrute, Kory J Lavine, Et Al.

2020-Current year OA Pubs

Myocardial infarction (MI) continues to be a leading cause of death worldwide. Even though it is well established that the complex interplay between different cell types determines the overall healing response after MI, the precise changes in the tissue architecture are still poorly understood. In this study, we generated an integrative cellular map of the acute phase after murine MI using a combination of imaging-based transcriptomics (Molecular Cartography) and antibody-based highly multiplexed imaging (Sequential Immunofluorescence). This enabled us to evaluate cell type compositions and changes at subcellular resolution over time. We observed the recruitment of leukocytes to the infarcted heart …

Identification Of Surrogate Outcome Biomarkers In Lung Allograft Recipients With Bronchiolitis Obliterans: Implications For Randomized Controlled Trials, Derek E. Byers, Suresh Vedantham, Mary Clare Derfler, Paul Commean, Andrew Atkinson, Jeff Atkinson, Alexey Prokudin, John Mccarthy, George Despotis, Et Al.

2020-Current year OA Pubs

BACKGROUND: We developed a prospective, multicenter "registry" to evaluate the effect of extracorporeal photopheresis for lung transplant recipients who develop chronic lung allograft dysfunction (CLAD) with the bronchiolitis obliterans syndrome (BOS) phenotype (CLAD/BOS) and who are refractory to conventional standard-of-care therapy.

METHODS: Data from 258 lung transplant recipients enrolled in the Registry between April 2015 and April 2022 were included in this analysis. All recorded parameters (eg, demographics), including forced expiratory volume in 1 s (FEV

RESULTS: Mortality at 6 and 12 mo after CLAD/BOS diagnosis was 5% and 14%, whereas mortality at 6 and 12 mo after enrollment was …

Cephalopod Consciousness: Asking The Right Questions, Gordon Burghardt

Animal Sentience

Jennifer Mather has provided a comprehensive and fascinating overview of the various cognitive accomplishments of cephalopods and their sensory, behavioral, and neurophysiological attributes. The advances in our understanding of a clade that has been separated from vertebrate evolution by well over half a billion years is a testament to advances in both methodology and the questions we now feel free to address. Mather embeds her review in the issue of consciousness, which is certainly a perennial issue in mental evolution, going back to Romanes and earlier. I argue that the term “consciousness” has such a checkered history and is used …

Our Town Upland Campaign, Claire Yew

Public Relations Student Projects

This promotional campaign, developed by Taylor University’s 2025 PR Cases & Campaigns class in partnership with Our Town Upland, aims to enhance the visibility and vitality of Upland, Indiana. Grounded in research on the town’s history, demographics, and community culture, the campaign identifies key opportunities to strengthen local partnerships, increase visitor engagement, and deepen connections between Taylor University students and the broader community. The plan outlines strategic initiatives, including community events, business collaborations, internship programs, and targeted marketing efforts intended to attract visitors, increase event participation and elevate Upland’s profile. Through a combination of print and social media, and experiential …

College Of Natural Sciences Newsletter, Fall 2025, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

P.1 Dean's Message from Dr. Sen Subramanian
P.2 Student Spotlights
P.3 One Day for STATE
P.4 Fun Filming with Jack
P.5 Germanium Studies
P.6 Research Expenditures
P.8 Increased Enrollment
P.9 Faculty Recognition
P.11 Scoops & Smiles

Environmental Receipts: The Ecological Footprint Of Multilateral Development Banks, Mike Wigdor

Student Publications

This paper assesses whether membership in multilateral development banks (MDBs) is associated with lower ecological footprints. Drawing on country-year data from the 2025 Quality of Government (QoG) Basic Dataset and the Correlates of War (CoW) IGO Dataset, I analyze 1,714 observations from 1970–2008. Ecological footprint (global hectares per capita) is used as the dependent variable, while the central explanatory variable is the total number of MDB memberships annually. I utilize an OLS regression model controlling for logged GDP per capita, regime type, oil production value, urbanization, and economic globalization. Contrary to my hypothesis that MDB safeguards, norm diffusion, and pooling …

Using Constructivist Grounded Theory Study To Understand The Retention Rate Of The School Of Automotive, Southern Illinois University Carbondale, Illinois, Lana Rizzo

Ed.D. Capstone Reports

This study explored students’ reasons for returning and continuing their education in the School of Automotive. Therefore, this study developed an understanding of the higher-than-average retention rate for the School of Automotive at Southern Illinois University at Carbondale, Illinois. This study used a constructivist grounded theory approach, and the data came from semi-structured interviews. As this is a constructivist grounded theory study, the students and I co-created the theory behind this phenomenon.

Remote Sensing Of American Revolutionary War Fortification At Butts Hill (Portsmouth, Rhode Island), James G. Keppeler, Marcus Rodriguez, Samuel Koontz, Alexander Wise, Philip Mink, George Crothers, Paul R. Murphy, John K. Robertson, Hugo Reyes-Centeno, Alexandra Uhl

Anthropology Faculty Publications

The Battle of Rhode Island in 1778 was an important event in the revolutionary war leading to the international recognition of U.S. American independence following the 1776 declaration. It culminated in a month-long campaign against British forces occupying Aquidneck Island, serving as the first combined operation of the newly formed Franco-American alliance. The military fortification at Butts Hill in Portsmouth, Rhode Island, served as a strategic point during the conflict and remains well-conserved today. While LiDAR has assisted in the geospatial surface reconstruction of the site’s earthwork fortifications, it is unknown whether other historically documented buildings within the fort remain …

Morphology-Performance Relationships To Understand Cichlid Neurocranial Evolution In The Context Of Adaptive Radiation, Sarah Pascarella

Theses and Dissertations from DePaul University

Cichlid fishes have undergone multiple adaptive radiations in the rift lakes of East Africa pairing rapid taxonomic and morphological diversification. Lake Malawi’s rock-dwelling cichlids (mbuna) have diversified into hundreds of species that partition their habitat by depth and diet resulting in high morphological and behavioral diversity. We characterized morphological differences and performed behavioral assays among four cichlid genera from Lake Malawi focused on understanding form-function relationships in the neurocranium and oral feeding apparatus. We characterized neurocranial shape using 3D geometric morphometrics across a large taxonomic sample of mbuna cichlids, focusing primarily on the Tropheops species complex. Alongside broad changes in …

Qisas: The Incremental Formation Of Jihad Amidst The Islamic Mujahideen Across The Middle And Near East, Jenny N. Liang

Armstrong Undergraduate Journal of History

Since its inception in seventh-century Arabia, Islamic thought and the concept of jihad have been present among Islamic scholars. Nevertheless, despite a history of conflict with Western nations through religious wars in the Near and Middle East, the rapid transformation of Islamic extremism by means of global terrorism in the late twentieth- and early twenty-first century ultimately traces to the Soviet invasion of Afghanistan and the rise of the Mujahideen. Islamic yearning for retribution through strategic retaliation began after December 1979, when Soviet Red Army troops invaded Afghanistan. Following the resolution of World War II and the emergence of a …

The Crime Of Being Immoral, Randy D. Gordon

Faculty Scholarship

Despite a general abhorrence of retrospective laws as a matter of legal theory and Constitutional dictate, US. courts continue-in es sence-to create new crimes by injecting fazzy moral considerations into determinations under the federal fraud statutes. They do so by deeming a failure to act with "moral uprightness" sufficient to consti tute criminal fraud. Under such an amorphous standard, the unwitting find themselves in a legal bind, even though their conduct may not in volve any of the traditional elements of common-law fraud. This Article traces the roots of novel fraud theories with tools drawn from legal theory, linguistics, and …

Validation Of A Mind Diet Screener In Older Adults, Desarae A. Dempsey, Puja Agarwal, Shane Fernandez, Jared R. Brosch, Sujuan Gao, Daniel O. Clark, Frederick W. Unverzagt, Liana G. Apostolova, David G. Clark, Martin R. Farlow, Sunu Mathew, Sophia Wang, Michelle Quirke, Yolanda Graham-Dotson, Colette Blach, Leyla Schimmel, Rima Kaddurah-Daouk, Andrew J. Saykin, Shannon L. Risacher

Research outputs 2022 to 2026

Introduction: Higher adherence to the Mediterranean-DASH (Dietary Approaches to Stop Hypertension) Intervention for Neurodegenerative Delay (MIND) diet has been associated with reduced Alzheimer's disease (AD) risk. This study assessed the validity of a brief 15-item MIND diet screener compared to a comprehensive food frequency questionnaire (FFQ). Methods: The validity of an adapted MIND diet screener relative to the VioScreen FFQ was evaluated in 92 older adults from the Indiana Alzheimer's Disease Research Center (IADRC). Correlation coefficients and tertile-based classification statistics were used, and FFQ nutrient profiles were examined across screener-based MIND diet tertiles. Results: MIND diet scores from the screener …

Design Of A Robust Adaptive Cascade Fractional-Order Proportional–Integral–Derivative Controller Enhanced By Reinforcement Learning Algorithm For Speed Regulation Of Brushless Dc Motor In Electric Vehicles, Seyyed Morteza Ghamari, Mehrdad Ghahramani, Daryoush Habibi, Asma Aziz

Research outputs 2022 to 2026

Brushless DC (BLDC) motors are commonly used in electric vehicles (EVs) because of their efficiency, small size and great torque-speed performance. These motors have a few benefits such as low maintenance, increased reliability and power density. Nevertheless, BLDC motors are highly nonlinear and their dynamics are very complicated, in particular, under changing load and supply conditions. The above features require the design of strong and adaptable control methods that can ensure performance over a broad spectrum of disturbances and uncertainties. In order to overcome these issues, this paper uses a Fractional-Order Proportional-Integral-Derivative (FOPID) controller that offers better control precision, better …

Accelerating Precision Exercise Medicine In Cancer Patients Using Pooled Individual Patient Data: Polaris Experience, Laurien M. Buffart, Marlou Floor Kenkhuis, Robert U. Newton, Anne M. May, Daniel A. Galvão, Kerry S. Courneya

Research outputs 2022 to 2026

Numerous exercise oncology trials have been completed, greatly informing exercise recommendations for patients with cancer. Exercise medicine can be administered in various types, doses, and schedules at various time points. Advancing precision exercise medicine requires understanding of how the effects of different exercise interventions vary by characteristics of individual patients. The Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) study provides an international infrastructure and shared database to perform pooled analyses of individual patient data (IPD) from multiple randomized controlled trials. This commentary aims to highlight the value of pooled IPD analyses, summarize key findings from published pooled IPD analyses …

The Consequences Of Habitual Rumination, Expressive Suppression, And Perceived Stress On Mental And Physical Health Among Older Adults, Eyal Gringart, Rodrigo Becerra, Andrea Smith

Research outputs 2022 to 2026

Background/Objectives: The current study aimed to investigate whether habitual rumination, suppression, and perceived stress predict poor mental and physical health as well as well-being in a group of older adults (aged 50 to 80 years) from a non-clinical community sample. Methods: The current study comprised a cross-sectional survey design with online self-report measures. It was predicted that higher levels of rumination, suppression, and perceived stress would predict lower levels of general health as well as well-being, and heightened levels of depression and anxiety. Results: Findings from the study indicated that both rumination and perceived stress significantly predicted heightened anxiety, heightened …

Characterization Of Pigeonpea As An Alternate Summer Forage Crop In Virginia, Satya S. S. Narina, Glenn Chappell Iii, Harbans L. Bhardwaj

Virginia Journal of Science

Pigeonpea (Cajanus cajan L.), a major multifunctional food legume crop valued globally, contributes to food security by supplying protein-rich grain for human consumption and provides nutrient-rich biomass for livestock feeding across diverse production systems. However, little is known about its forage potential in the mid-Atlantic region of the United States. In 2009 and 2010, four cultivars (GA-1, GA-2, W-1, and W-3) were evaluated in a split-plot design with three intra-row plant populations (2, 4, or 6 plants per 0.3 m row) and three planting dates (May, June, and July). Forage yield, crude protein, minerals, and other nutritional traits were …

Finding Aid For University Of Mississippi Small Manuscripts(Mum01771)

Archives & Special Collections: Finding Aids (alphabetical)

The collection contains items related to the University of Mississippi. The collection is arranged by subject.

Toward The Human Right To Water For Vulnerable Communities: The Effectiveness Of Stakeholder Processes To Control Regional Shallow Groundwater Contamination By Nitrates, Iris Stewart, John Dialesandro, Samantha Lei, Lilah Foster

Environmental Studies and Sciences

Nitrate contamination in shallow drinking water wells is an urgent and persistent concern for agricultural regions and disadvantaged communities worldwide. As viable options for the large-scale removal of nitrates from groundwater remain elusive, greater emphasis has been placed on stakeholder-based integrative approaches, yet few have been developed, and fewer evaluated for their effectiveness. The Central Valley in California is one of the most important intensive agricultural regions globally, where such a stakeholder-based process (CV-SALTS) has been initiated, and which is poised to serve as a model for controlling nitrate contamination elsewhere. Based on the Groundwater Ambient Monitoring and Assessment Program …

Fundamentals Of A Sustainability Profile Of Students Based On Quantitative Community Building Analyses, Cormac Mcmahon, Julie Dunne, Catherine Barry Ryan, María J. Cantalejo, Carlos Vilches, Isabel Navarlaz, Maite Aldaya, Annapia Ferrara, Sabrina Tomasi, Chiara Mignani, Alessio Cavicchi, Sami Sami Ghnimi, Sghaier Chriki, Michael Murkovic, Barbara Siegmund, Lena Pfeiffer

Research Outputs: 2025-Present

In the context of a growing awareness of environmental challenges and the importance of sustainability values, practices, and choices, this article presents the key findings of the European co-funded NEMOS research project (A New Educational Model of Sustainability Competences through Service-learning) focused on defining the sustainability profile and competencies of students through service-learning in Higher Education. A community-building bottom-up methodology was innovatively applied to identify the competencies needed to define a sustainability profile of students in food-related degrees of five European Higher Education Institutions.The research findings highlight the need for a holistic understanding of students´sustainability, including economic, social, and environmental …

(Si15-142) Selection Of Single Sampling Plans Based On Zero Inflated Binomial Distribution Using Cost Optimization, Sangeetha S., Shalini K., Hemalatha R., Priyadharshini R.

Applications and Applied Mathematics: An International Journal (AAM)

Economic design of sampling plans involves creating sampling plans that minimize the total cost associated with the inspection process while ensuring quality. It aims to address the quality risk concerns of both producer and consumer, ensuring product quality while minimizing inspection costs. This article’s objective is to design single sampling plans by attributes based on Zero-inflated Binomial (ZIB) distribution, using cost optimization principles by developing an economic model aimed at achieving optimal total cost by considering the Average Total Inspection (ATI). Numerical illustration is provided to illustrate the selection of single sampling plans under ZIB distribution that minimizes producer’s total …

(Si15-093) Dynamics Of The Generalized Nonlinear Schrödinger Equation With A Source Using An Analytical Method, Manish Raghav, Manoj .

Applications and Applied Mathematics: An International Journal (AAM)

In the present article, an analytical method is used to obtain hyperbolic, trigonometric, and rational solutions of the generalized nonlinear Schrödinger (GNLS) equation with a source. The ability of solitons to preserve their shapes during propagation makes them suitable for optical fiber communication. Solutions to the generalized nonlinear Schrödinger equation with a source can also describe solitons, and understanding their dynamics helps to design communication systems based on solitons. The analytical method used is compelling and effective for finding exact solutions to various nonlinear evolution equations (NLEEs). To further understand the phenomena, we create 3−D, contour, and 2−D graphs of …

(Si15-107) Mathematical Modeling Of Cancer Dynamics Stability Analysis Of Post Therapy Protection, Rajendran Swetha, Tharmalingam Gunasekar, Kamalendra Kumar, Krishnasamy Sakthivel

Applications and Applied Mathematics: An International Journal (AAM)

The study of PSITPS mathematical model is developed to analyze cancer dynamics, focusing on post-therapy protection. The model’s solution is rigorously examined for boundedness and positivity of solutions. Equilibrium points are identified, and numerical methods are employed to study stability. Simulations using accurate cancer data demonstrate the effectiveness of post-treatment protection in controlling cancer spread and minimizing recurrence. Stability analysis confirms the model’s predictive capability, offering valuable insights into long-term patient outcomes. The results highlight the importance of continuous post-treatment care in improving survival rates and reducing disease prevalence. This study provides a framework for optimizing cancer treatment strategies by …

Concurrent Local Therapy Extends Clinical Benefit Of Tebentafusp In Metastatic Uveal Melanoma Patients, Tristan L. Lim, Kamaneh Montazeri, Eric Wehrenberg-Klee, Antoine Desilets, Rino S. Seedor, Marlana Orloff, Takami Sato, Michael Caplan, Mariam El-Ashmawy, Benjamin Izar, Shaheer Khan, Inderjit Mehmi, Aleigha Lawless, Theodore S. Hong, Omid Hamid, Richard D. Carvajal, Alexander Shoushtari, Ryan J. Sullivan

Kimmel Cancer Center Faculty Papers

BACKGROUND: Tebentafusp has significantly improved overall survival in HLA-A*02:01+ metastatic uveal melanoma (mUM) patients even in those with a best objective response of progressive disease. Thus, strategies to maintain tebentafusp therapy are critical. Here, we examine the efficacy and safety of adding concurrent local therapy (CLT) to tebentafusp upon radiological progression with tebentafusp alone.

PATIENTS AND METHODS: This multicenter retrospective study included mUM patients treated with tebentafusp and CLT, consisting of extrahepatic soft tissue irradiation and liver-directed therapies (LDTs). Efficacy of target and nontarget sites were assessed per RECIST version 1.1. PFS with tebentafusp alone (PFS1) was compared to that …