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Articles 4681 - 4710 of 31393
Full-Text Articles in Entire DC Network
Park Reclamation: Tackling Invasive Species At The Oconee River Greenway In Milledgeville, Ga, Christine Mutiti
Park Reclamation: Tackling Invasive Species At The Oconee River Greenway In Milledgeville, Ga, Christine Mutiti
Academic Affairs
This project focused on the ecological restoration of a kudzu-invaded section of the Oconee River Greenway while integrating high-impact learning into the Environmental Methods and Measurements (ENSC 2000) course at GCSU. Kudzu (Pueraria montana), a Category I invasive species, has significantly disrupted native plant communities at the site, making it an ideal setting for applied learning and ecological intervention. The project engaged students in authentic environmental research by involving them in every stage of the process including problem assessment, methodology design, field implementation, data collection, and reflection.
Students initiated the first phase of invasive plant removal using mechanical …
First Use Of The Ku-F600 Automated Analyzer For Descriptive Epidemiology Of Blastocystis Sp. In Erbil, Iraq., Hana Hakim Qadir, Hemdad Hawez Mawlood
First Use Of The Ku-F600 Automated Analyzer For Descriptive Epidemiology Of Blastocystis Sp. In Erbil, Iraq., Hana Hakim Qadir, Hemdad Hawez Mawlood
Polytechnic Journal
Blastocystis is a common protozoan parasite of the gastrointestinal tract. This study aimed to determine the prevalence, risk factors, and potential pathogenicity of Blastocystis sp. in Erbil province, Iraq, using the KU-F600 Automated Feces Analyzer (AFA).Notably, this is the first study to use this device in Iraq. A total of 580 fecal specimens were collected from patients attendending Mehrabani Surgical Hospital. Samples were tested using the KU-F600 AFA, which incorporates AI-based examination of microscopically identified parasites. demographic and clinical data were collected through questionnaires. All the statistical calculations were performed by GraphPad Prism 10. The prevalence of Blastocystis sp. was …
Letting Government Breathe: How Zoning Deregulation Provides A Workable Solution To Homelessness, Nicholas G. Glover, Esq.
Letting Government Breathe: How Zoning Deregulation Provides A Workable Solution To Homelessness, Nicholas G. Glover, Esq.
Fordham Urban Law Journal Online
No abstract provided.
Adopting Stuart Hall’S “Race, The Floating Signifier” As A Conceptual Framework Within Aquatic Research And Education, Kurt J. Cordice
Adopting Stuart Hall’S “Race, The Floating Signifier” As A Conceptual Framework Within Aquatic Research And Education, Kurt J. Cordice
International Journal of Aquatic Research and Education
During his 1997 lecture at Goldsmiths College in London, Stuart Hall, renowned for his contributions to sociology and cultural studies, offered his argument that the concept of race functions as a Floating Signifier. In this essay, Stuart Hall’s Race, the Floating Signifier is presented as a strong conceptual framework to support more accurate and effective positioning of race as an important consideration within aquatic research and education. Evidence from a range of disciplines, including historical research, is presented to establish both the importance and challenge of race within aquatic research and education. This evidence is also used to demonstrate …
Sociology Between The Gaps Volume 10 (2025)
Sociology Between The Gaps Volume 10 (2025)
Sociology Between the Gaps: Forgotten and Neglected Topics
No abstract provided.
October 15, 2025 Faculty Senate Minutes, University Of South Carolina
October 15, 2025 Faculty Senate Minutes, University Of South Carolina
Faculty Senate
No abstract provided.
Advances In Application Of Steam Explosion Technology In Edible Mushroom Industry, Jie Yang, Na Zheng, Chunmei Lai, Mingyi Liu, Shibo Li, Shanshan Wei, Pufu Lai, Zheng Xiao
Advances In Application Of Steam Explosion Technology In Edible Mushroom Industry, Jie Yang, Na Zheng, Chunmei Lai, Mingyi Liu, Shibo Li, Shanshan Wei, Pufu Lai, Zheng Xiao
Journal of Food Science and Biotechnology
Steam explosion technology,an emerging physical pretreatment method,is increasingly applied in the edible mushroom industry.This technology subjects materials to instantaneous explosion under high-temperature and high-pressure steam,significantly improving their physical structures and chemical composition.It exhibits unique strengths in modifying edible mushroom cultivation substrates,extracting active compounds,and utilizing by-products as resources. This provides a new technical path for the high-quality development of the edible mushroom industry.The author primarily summarizes the equipment,principles,and influencing factors of steam explosion technology,as well as its diverse roles in modifying cultivation substrates,extracting active substances from edible mushrooms,and achieving high-value utilization of edible mushroom by-products.The aim is to promote positive development …
Research Progress In Effects Of Electron Beam Irradiation On The Storage Andquality Of Grains, Xiuxia Chen, Bin Zhang
Research Progress In Effects Of Electron Beam Irradiation On The Storage Andquality Of Grains, Xiuxia Chen, Bin Zhang
Journal of Food Science and Biotechnology
Conventional grain storage methods have a variety of drawbacks.Electron beam irradiation,as an emerging non-thermal processing technology,has attracted attention due to its high efficiency,environmental friendliness,and minimal impact on grain quality.The author elaborates on the principles of electron beam irradiation and its applications in the food industry,reviews its effects on harmful organisms,physicochemical properties,and sensory quality of grains during storage,and makes an outlook on its future application prospects,with the expectation of promoting the application and popularization of electron beam irradiation in food storage.
Ultrasonic-Microwave Assisted Extraction Of Flavonoids From Citri Reticulatae Pericarpium And High-Purity Purification Of Hesperidin, Weiben Ge, Yiheng Li, Hongxin Wang
Ultrasonic-Microwave Assisted Extraction Of Flavonoids From Citri Reticulatae Pericarpium And High-Purity Purification Of Hesperidin, Weiben Ge, Yiheng Li, Hongxin Wang
Journal of Food Science and Biotechnology
[Objective ] To explore the application prospects of Citri Reticulatae Pericarpium in the food industry and efficiently extract the active component hesperidin,while developing an effective purification process to enhance the purity and functional value of the active ingredients.[Method ] Ultrasonic-microwave assisted extraction (U-MAE ) was employed to extract the hesperidin from Citri Reticulatae Pericarpium,followed by a three-stage purification system guided by dissolution characteristics involving alcohol removal by concentration,gradient ethanol washing,and pH adjustment to purify hesperidin.Single factor experiments and response surface methodology were used to optimize the extraction parameters.The antioxidant activity and α-glucosidase inhibitory activity of the final product were also …
Establishment Of A Hplc Method For Simultaneous Determination Of 11 Phenolic Acids In Germinated Black Wheat, Qian Li, Xiaodong Li, Ziyi Yang, Yueyao Zhang, Rui Liu, Zhanglong Yu, Yuanlin Sun
Establishment Of A Hplc Method For Simultaneous Determination Of 11 Phenolic Acids In Germinated Black Wheat, Qian Li, Xiaodong Li, Ziyi Yang, Yueyao Zhang, Rui Liu, Zhanglong Yu, Yuanlin Sun
Journal of Food Science and Biotechnology
[Objective ] In order to study the effects of germination on the mass fractions of phenolic acids in black wheat,a method was established for simultaneous determination of 11 phenolic acids (gallic acid,protocatechuic acid,4-hydroxybenzoic acid,chlorogenic acid,vanillic acid,caffeic acid,syringic acid,p-coumaric acid,ferulic acid,sinapic acid,and salicylic acid ) in germinated black wheat based on high performance liquid chromatography (HPLC ).[Method ] The mobile phase composed of methanol (containing acetic acid at a volume fraction of 1%) and water (containing acetic acid at a volume fraction of 1%) was used for gradient elution at a flow rate of 1 mL/min,a detection wavelength of 280 nm,and …
Dual-Nozzle 3d Printing And Drying Characteristics Of A Hawthorn Snack Based On Dual-Material Combination Gel, Aimiao Wang, Bo Wang, Yuchuan Wang, Jiguang Liu
Dual-Nozzle 3d Printing And Drying Characteristics Of A Hawthorn Snack Based On Dual-Material Combination Gel, Aimiao Wang, Bo Wang, Yuchuan Wang, Jiguang Liu
Journal of Food Science and Biotechnology
[Objective ] This study aims at solving the problems such as long drying time,single product shape,and poor 3D printing capacity (easy blockage and weak bracing ability ) in conventional processing of hawthorn snack products.[Method ] The low-sugar hawthorn jam and high-sugar banana jam were used as gel components.The 3D printing was carried out with the optimization of dual-material combination gel formula and the optimization of dual-nozzle 3D printing process.Furthermore,the drying characteristics of 3D printing were analyzed and compared with those of conventional dried hawthorn products.[Result ] The combination of hawthorn jam with the sugar mass fraction of 26% and banana …
Respiratory Characteristics Of Late-Maturing Sweet Cherry Cultivars And Their Influence By Temperature And Packaging Methods, Huanhuan Zhi, Yu Dong
Respiratory Characteristics Of Late-Maturing Sweet Cherry Cultivars And Their Influence By Temperature And Packaging Methods, Huanhuan Zhi, Yu Dong
Journal of Food Science and Biotechnology
[Objective ] This study aims to develop suitable packaging strategies for sweet cherry varieties with different respiratory characteristics.[Method ] The sweet cherry cultivars ‘Lapins’ and ‘Regina’ were put in closed systems with different O 2 volume fractions at 0,5,and 10 ℃.The changes in O 2 consumption rate,CO 2 consumption rate,and respiratory quotient were monitored.Additionally,the changes of gas components,quality,and physiological disorders were assessed for the two cultivars treated with polyethylene (PE) and modified atmosphere packaging (MAP ) after 4 weeks of storage at 0,5,and 10 ℃.[Result ] ‘Lapins’ had lower O 2 consumption rate and CO 2 consumption rate than ‘Regina’ …
Effects Of Ginger Protease On Beef Quality And Protein Degradation, Xinghua Chen, Shuhong Liu, Huaisheng Zheng, Zhaobin Huang, Ping Hu
Effects Of Ginger Protease On Beef Quality And Protein Degradation, Xinghua Chen, Shuhong Liu, Huaisheng Zheng, Zhaobin Huang, Ping Hu
Journal of Food Science and Biotechnology
[Objective ] This study aims to investigate the effects of ginger protease on beef tenderness.[Method ] Ginger protease was extracted from mature ginger via ammonium sulfate precipitation.The fundamental properties of the ginger protease,including enzyme activity,protein mass fraction,optimal temperature and pH,and relative molecular mass,were evaluated.Furthermore,the effects of ginger protease on the physicochemical properties,sensory quality,microstructure,and protein degradation characteristics of beef were examined.[Result ] Ginger protease was mainly composed of two proteins with relative molecular masses of 15 293 and 34 191,with a total protein mass fraction of (574.60±0.25) mg/g,an enzyme activity of (31 787±307) U/g,an optimum temperature of 60 ℃,and an optimum …
Recombinant Pichia Pastoris Fermentation For Biosynthesis Of The Uv Resistant Compound Gadusol, Wenjie Zuo, Ping Zhang, Ruirui Xu, Leyi Zhang, Zhen Kang, Jianghua Li
Recombinant Pichia Pastoris Fermentation For Biosynthesis Of The Uv Resistant Compound Gadusol, Wenjie Zuo, Ping Zhang, Ruirui Xu, Leyi Zhang, Zhen Kang, Jianghua Li
Journal of Food Science and Biotechnology
[Objective ] This study aims to employ synthetic biology and metabolic engineering techniques to engineer Pichia pastoris (P.pastoris ) for the efficient heterologous synthesis of the UV resistant compound gadusol.[Method ] On the basis of a bioinformatic analysis and codon optimization of the genes involved in the gadusol biosynthetic pathway in Danio rerio,the gadusol fermentation pathway was constructed in P.pastoris via strategies such as promoter engineering,metabolic engineering,and fermentation optimization.[Result ] A high-purity gadusol standard was prepared through optimized extraction and chromatographic separation.The gadusol yield in the recombinant strain P.pastoris HME reached 105 mg/L.By screening of gene expression promoters and optimization …
Effects Of Critical Environmental Factors On The Antimicrobial Activity Of Ε-Poly- L-Lysine, Zhenjie Liu, Peihao Huang, Shu Chen, Shun Rong, Feiting Peng, Ling Chen, Weipeng Guo
Effects Of Critical Environmental Factors On The Antimicrobial Activity Of Ε-Poly- L-Lysine, Zhenjie Liu, Peihao Huang, Shu Chen, Shun Rong, Feiting Peng, Ling Chen, Weipeng Guo
Journal of Food Science and Biotechnology
[Objective ] This study explored the effects of critical environmental factors [water activity (aw),pH,and temperature ] on the antimicrobial activity of ε-poly- L-lysine (ε-PL),aiming to provide a basis for the application of ε-PL.[Method ] With Staphylococcus aureus as an indicator strain,the micro-broth dilution and agar dilution methods as well as antimicrobial growth kinetics were utilized to determine the antimicrobial activity of ε-PL.The protein leakage assay was employed to evaluate the bacterial membrane disruption activity of ε-PL.Live/Dead fluorescence staining was performed to observe the bacterial membrane permeability.[Result ] The minimum inhibitory mass concentration (MIC ) of ε-PL against Staphylococcus aureus was …
Probiotic Properties Of Three Strains Of Lactobacillus And Their Application In Corn Husk Fermentation, Bo Zhai, Quanxian Shu, Xiaoyan Yang, Yin Mao, Yu Deng, Yunying Zhao
Probiotic Properties Of Three Strains Of Lactobacillus And Their Application In Corn Husk Fermentation, Bo Zhai, Quanxian Shu, Xiaoyan Yang, Yin Mao, Yu Deng, Yunying Zhao
Journal of Food Science and Biotechnology
[Objective ] This study aims to improve the utilization of maize resources and address the shortage of feed resources.[Method ] The intestinal colonization capacity,tolerance,and antibacterial properties of three Lactobacillus strains,Lactobacillus paracasei ZB- 1 (ZB-1),L.paracasei DY- 2 (DY-2),and L.rhamnosus DY- 4 (DY-4) were evaluated.The most suitable strain for fermenting cornhusks was identified,and its fermentation process was optimized.[Result ] ZB-1 exhibited higher intestinal colonization ability and antibacterial properties than DY- 2 and DY- 4.The antibacterial mechanism of ZB- 1 was likely driven by the action of organic acids in an acidic environment and certain protein-based antimicrobial substances.The fermentation conditions for ZB- 1 …
Diversity Of Fungi On The Surfaces Of Grapes And Raisins In Turpan , Xinjiang, Lei Sun, Laifang Qi, Qiuyan Liang, Jinxuan Han, Tianli Fan, Yuhua Ma
Diversity Of Fungi On The Surfaces Of Grapes And Raisins In Turpan , Xinjiang, Lei Sun, Laifang Qi, Qiuyan Liang, Jinxuan Han, Tianli Fan, Yuhua Ma
Journal of Food Science and Biotechnology
[Objective ] This study aims to understand the potential harmful fungi that may affect the quality of raisins during the drying process of grapes from Turpan,Xinjiang and to explore the relationships between varieties and the fungal community structure and diversity on the surfaces of grapes and raisins.[Method ] Four popular grape varieties (‘Thompson Seedles s’,‘Boert e’,‘Xiangfe i’,and ‘Seedless Blac k’) in a grapery in Turpan were selected as research objects.The fungal diversity on the surfaces of grapes and raisins was analyzed via high-throughput sequencing.[Result ] The dominant fungal phyla on the surfaces of grapes and raisins were Ascomycota and Basidiomycota.The …
Regulatory Effects Of Hesperetin And Eriocitrin On Gut Microbiota In An In Vitro Simulation Model, Zeren Cheng, Xia Meng, Kejing Tang, Ling Shen, Qing Gu, Ping Li
Regulatory Effects Of Hesperetin And Eriocitrin On Gut Microbiota In An In Vitro Simulation Model, Zeren Cheng, Xia Meng, Kejing Tang, Ling Shen, Qing Gu, Ping Li
Journal of Food Science and Biotechnology
[Objective ] This study aims to compare the effects of hesperetin and eriocitrin on the gut microbiota in different enterotypes.[Method ] An in vitro gut fermentation model was established,which was combined with 16S rRNA high-throughput sequencing and gas chromatography-mass spectrometry (GC-MS ) technique to evaluate the regulatory effects of the two flavonoids on the gut microbiota in different enterotypes.[Result ] After fermentation,both flavonoids significantly reduced the Firmicutes-to-Bacteroidota ratio (F/B ratio ) in terms of relative abundance at the phylum level in enterotype Bacteroides and enterotype Prevotella.At the genus level,pro-inflammatory bacteria including Paeniclostridium and Sutterella showed decreased relative abundance in treatment …
Effects Of Ultrasound-Assisted Enzymatic Extraction On The Physical And Chemical Properties Of Tortoise Shell Collagen, Xiong He, Rongxing Li, Shaotong Jiang, Jianfeng Lu, Lin Lin
Effects Of Ultrasound-Assisted Enzymatic Extraction On The Physical And Chemical Properties Of Tortoise Shell Collagen, Xiong He, Rongxing Li, Shaotong Jiang, Jianfeng Lu, Lin Lin
Journal of Food Science and Biotechnology
[Objective ] The effects of different extraction methods on the yield,purity,structural characteristics,and physicochemical properties of tortoise shell collagen were investigated.[Method ] The ultrasound-assisted enzymatic method,acid method,and enzymatic method were used to extract collagen from tortoise shell powder.[Result ] The yield and purity of tortoise shell collagen extracted by ultrasound-assisted enzymatic method were 2.29% and 85.65%,respectively,significantly higher than those extracted by acid method (0.78% and 73.15%) and enzymatic method (1.77% and 75.63%).Ultraviolet absorption spectroscopy,infrared absorption spectroscopy,circular dichroism spectroscopy,and electrophoresis profiles showed that collagens extracted from tortoise shell by three methods were all type I collagen and retained intact triple helix structures.X-ray …
2025-10-15 Seeds Of Change: How Seattle Students Are Growing Community Through Urban Farming, Fatima Ali
2025-10-15 Seeds Of Change: How Seattle Students Are Growing Community Through Urban Farming, Fatima Ali
The Spectator Online
No abstract provided.
Justice Impacted Mothers: An Autoethnographic Study Exploring The Impacts Of Quality Prison Visitation With Children, Sarah E. Gore
Justice Impacted Mothers: An Autoethnographic Study Exploring The Impacts Of Quality Prison Visitation With Children, Sarah E. Gore
PSU McNair Scholars Online Journal
This study explores the impacts of in-person visitation at correctional facilities and how the quality of this contact affects relationships between justice impacted mothers and their children. Little is known about these nuanced lived experiences as revealed by qualitative data and from someone who is mothering during incarceration. The literature on maternal incarceration is vast, but relies heavily on quantitative data. Existing research indicates facility visits, particularly those of high quality, offer constructive benefits such as reductions in maternal recidivism rates. However, separation during incarceration has shown higher risks for adolescent substance abuse, behavioral, and academic struggles. This study expands …
The Lumberjack, October 15, 2025
The Lumberjack, October 15, 2025
Cal Poly Humboldt's Student Newspaper
The student newspaper of Humboldt State University.
College Of Liberal Arts Faculty Bylaws 2025-2026, College Of Liberal Arts Faculty, Rollins College
College Of Liberal Arts Faculty Bylaws 2025-2026, College Of Liberal Arts Faculty, Rollins College
College of Liberal Arts Bylaws
No abstract provided.
Treating Low-Concentration Methane Emissions Via A Methanotroph-Based Biotrickling Filter: Techno-Economic And Life Cycle Assessment, Waaseyaaban Landgren, Robert Handler, David Shonnard, Mary E. Lidstrom
Treating Low-Concentration Methane Emissions Via A Methanotroph-Based Biotrickling Filter: Techno-Economic And Life Cycle Assessment, Waaseyaaban Landgren, Robert Handler, David Shonnard, Mary E. Lidstrom
Michigan Tech Publications
Methane, a greenhouse gas which has a global warming potential 80 times greater than carbon dioxide on a 20-year time scale, greatly contributes to global warming. Removing 1 Gt of atmospheric methane by 2050 would limit global temperature increase from reaching 1.5 °C. Currently, biotrickling filter systems for removing atmospheric methane via methanotrophs exist, but not for very low methane concentrations (< 1 v%). Recent work at the University of Washington to isolate and improve a microbial strain which thrives at 500 ppmv CH4 has removed one obstacle in making this technology feasible. In this study, techno-economic and environmental life cycle assessment analyses conducted on this process have assessed its economic feasibility, greenhouse gas reduction potential, and possible areas of improvement. Study results show that at 500 ppmv CH4, this process could remove atmospheric methane at a cost of USD 3992–5224/tCH4. The best-performing case also produces annual net reductions in warming potential by 276–311 tCO2e/120 m3 process unit deployed. Many opportunities exist to improve the outcomes of the baseline analysis even further, especially related to reducing the transport distance of media and harvested biomass.
Hydralazine Inhibits Cysteamine Dioxygenase To Treat Preeclampsia And Senesce Glioblastoma, Kyosuke Shishikura, Jiasong Li, Yiming Chen, Nate R. Mcknight, Thomas P. Keeley, Katelyn A. Bustin, Eric W. Barr, Snehil R. Chilkamari, Mahaa Ayub, Sun Woo Kim, Zongtao Lin, Ren-Ming Hu, Kelly Hicks, Xie Wang, Donald M. O'Rourke, J. Martin Bollinger, Zev A. Binder, William H. Parsons, Kirill A. Martemyanov, Aimin Liu, Megan L. Matthews
Hydralazine Inhibits Cysteamine Dioxygenase To Treat Preeclampsia And Senesce Glioblastoma, Kyosuke Shishikura, Jiasong Li, Yiming Chen, Nate R. Mcknight, Thomas P. Keeley, Katelyn A. Bustin, Eric W. Barr, Snehil R. Chilkamari, Mahaa Ayub, Sun Woo Kim, Zongtao Lin, Ren-Ming Hu, Kelly Hicks, Xie Wang, Donald M. O'Rourke, J. Martin Bollinger, Zev A. Binder, William H. Parsons, Kirill A. Martemyanov, Aimin Liu, Megan L. Matthews
SKMC Student Presentations and Publications
Hydralazine (HYZ), a treatment for preeclampsia and hypertensive crisis, is listed by the World Health Organization as an essential medicine. Its mode of action has remained unknown through its seven decades of clinical use. Here, we identify 2-aminoethanethiol dioxygenase (ADO), a key mediator of targeted protein degradation, as a selective HYZ target. The drug chelates ADO's metallocofactor and can alkylate one of its ligands. The resultant inactivation stabilizes regulators of G protein signaling (RGS4 and RGS5) that ADO normally marks for proteolysis, explaining the drug's vasodilatory activity and comporting with observations of diminished RGS levels in both clinical preeclampsia and …
Daily Eastern News: October 15, 2025, Eastern Illinois University
Daily Eastern News: October 15, 2025, Eastern Illinois University
Daily Eastern News: 2025-2026
No abstract provided.
Forecasting Monthly Rainfall In The Pirmam Area, Kurdistan Region, Iraq: A Machine Learning Approach., Sakar Muhamad, Rawshan Ali
Forecasting Monthly Rainfall In The Pirmam Area, Kurdistan Region, Iraq: A Machine Learning Approach., Sakar Muhamad, Rawshan Ali
Polytechnic Journal
Agriculture, emergency preparedness, and water resource management all depend on accurate rainfall forecasts. This study investigates how well machine learning models predict monthly rainfall in the Kurdistan Region of Iraq, specifically in the Pirmam area. Historical weather data was analyzed using a variety of models, such as Artificial Neural Networks (ANN), Adaptive Neuro-Fuzzy Inference System (ANFIS), Multiple Linear Regression (MLR), Least Absolute Shrinkage and Selection Operator (LASSO), Elastic Net (ELNET), and Ridge Regression. Statistical measures including Nash-Sutcliffe Efficiency (NSE), Mean Bias Error (MBE), Normalized Root Mean Squared Error (nRMSE), Coefficient of Determination (R2), and Root Mean Squared Error (RMSE) were …
Estrogen-Related Receptor Alpha Promotes Skeletal Muscle Regeneration And Mitigates Muscular Dystrophy, Thi Thu Hao Nguyen, Ya Xiang Huang, Svitlana Poliakova, Citu Citu, Eira Mann, Danesh H Sopariwala, Zhongming Zhao, Ashok Kumar, Vihang A Narkar
Estrogen-Related Receptor Alpha Promotes Skeletal Muscle Regeneration And Mitigates Muscular Dystrophy, Thi Thu Hao Nguyen, Ya Xiang Huang, Svitlana Poliakova, Citu Citu, Eira Mann, Danesh H Sopariwala, Zhongming Zhao, Ashok Kumar, Vihang A Narkar
The Brown Foundation: Institute of Molecular Medicine
Skeletal muscle regeneration in chronic muscle diseases such as Duchenne Muscular Dystrophy (DMD) has remained clinically unsurmountable. Estrogen‐related receptor alpha (ERRα) plays a critical role in adult skeletal muscle metabolism and exercise fitness. Whether ERRα activation can drive muscle regeneration and mitigate dystrophy in DMD is not known. We have investigated ERRα signaling in pre‐clinical models of acute muscle injury and DMD. ERRα is induced in differentiating C2C12 myoblast and regenerating muscle. ERRα silencing suppressed proliferation and differentiation in C2C12 myoblasts. RNA sequencing revealed that angiogenic factor and proliferation genes were downregulated by ERRα knockdown in proliferating cells, whereas oxidative …
Introducing Mcodegpt As A Zero-Shot Information Extraction From Clinical Free Text Data Tool For Cancer Research, Kai Zhang, Tongtong Huang, Bradley A Malin, Travis Osterman, Qi Long, Xiaoqian Jiang
Introducing Mcodegpt As A Zero-Shot Information Extraction From Clinical Free Text Data Tool For Cancer Research, Kai Zhang, Tongtong Huang, Bradley A Malin, Travis Osterman, Qi Long, Xiaoqian Jiang
Faculty, Staff and Student Publications
Background: The vast amount of natural language clinical notes about patients with cancer presents a challenge for efficient information extraction, standardization, and structuring. Traditional NLP methods require extensive annotation by domain experts for each type of named entity and necessitate model training, highlighting the need for an efficient and accurate extraction method.
Methods: This study introduces a tool based on the Large Language Model (LLM) for zero-shot information extraction from cancer-related clinical notes into structured data aligned with the minimal Common Oncology Data Elements (mCODE™) structure. We utilize the zero-shot learning capabilities of LLMs for information extraction, eliminating the need …