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Synthesis, Biological Evaluation, And Theoretical Studies Of 2-Amino-3-Cyano-4-(L-Phenylalaninyl)Quinolines: Anticancer Potential And Egfr Inhibition, İlbi̇lge Merve Şenol, Begüm Nurpeli̇n Sağlik Özkan, İlhami̇ Çeli̇k, Ahmet Çağri Karaburun

Turkish Journal of Chemistry

Quinoline derivatives have garnered significant attention owing to their wide range of biological activities, particularly their anticancer potential. In this study, six novel 4-aminoquinoline derivatives incorporating a phenylalanine methyl ester moiety were synthesized and structurally characterized. The cytotoxic activities of the synthesized compounds were assessed against A549 and MCF-7 cancer cell lines, along with the noncancerous NIH3T3 fibroblast cell line. Compounds 4d and 4e displayed potent anticancer activity with low IC₅₀ values, while exhibiting negligible toxicity toward normal cells. Moreover, these compounds exhibited moderate inhibitory activity against EGFR. Molecular docking studies were conducted to elucidate the binding modes of compounds …

K-Carrageenan Fabricated Γ-Irradiated Graphene Oxide Hydrogel: A Versatile Anticancer Nanodrug Carrier System, Samina Sarwar, Sumayya Aziz, Asif Raza, Tariq Yasin, Nuzhat Shafi

Turkish Journal of Chemistry

In this study, gamma-irradiated graphene oxide was incorporated into novel pH-responsive hydrogels. The biopolymer kappa carrageenan was blended with polyvinyl alcohol in a silane crosslinked biopolymer, and the effect of gamma irradiation dosage was studied. Nonhazardous tetraethoxysilane (TEOS) was used as a crosslinker. The hydrogels were characterized with chemical and thermal analysis, scanning electron microscopy, and structural analysis using a variety of analytical tools. The swelling behavior of fabricated hydrogels was assessed in various solution media. As the pH of the media increased, the swelling ratio of hydrogels decreased. All fabricated hydrogels had a high swelling ratio at acidic and …

Crow's Nest, October 20, 2025, Crow's Nest Staff

Crow's Nest

The October 20, 2025 issue of Crow's Nest.

Accessible Biocatalyst Development By Rapid In Vitro Semi-Rational Engineering (Rise) Of Enzymes, András Telek, Viktor Gaják, Gergő Dargó, Jan Mican, David Bednar, Beáta G. Vértessy, Gábor T Asnádi

Enzyme Engineering XXVIII

Please click Additional Files below to see the full abstract

Digital Enzyme Evolution: Creation Of A Fully Digitalized Enzyme Engineering Platform, Demonstrated Through The Multiparameter Engineering Of Imine Reductases (Ireds), Andrew Currin

Enzyme Engineering XXVIII

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Enzyme-Based Multiplex Biosensors For Biosynthetic Intermediates, Yoshiki Takemura, Yuki Kimura, Daisuke Umeno

Enzyme Engineering XXVIII

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Enzyme Engineering For Improving Thermostability Of Endolysin, Sasina Premjaichon, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen

Enzyme Engineering XXVIII

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Machine Learning For Scalable Molecular Dynamics And Evolution-Aware Protein Design, Pavel Kohout, Guillem Casadevall, Jiri Damborsky, Sílvia Osuna, Stanislav Mazurenko

Enzyme Engineering XXVIII

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Mcsa Forum Minutes 10/20/2025, Morris Campus Student Association

Morris Campus Student Association

No abstract provided.

The Unavoidable Consequences Of Homelessness, Sara K. Rankin, Laura Riley

Utah Law Review

The U.S. Supreme Court’s recent Grants Pass v. Johnson decision sounded the death knell for Eighth Amendment protections for people experiencing homelessness. The decision not only overruled key Ninth Circuit decisions, but also severely cabined the Court’s own precedent, allowing cities across the country to jail and fine people for doing nothing other than surviving in public space when they have no reasonable alternative. The Eighth Amendment’s prohibition against cruel and unusual punishment is a powerful symbol of America’s aspiration to realize the dignity and humanity of all its people, especially those who are marginalized and vulnerable to systemic discrimination …

Synthesis Of Vinyl Esters Of Aromatic Carboxylic Acids In The Presence Of Zn/Sioc, Zno/Sioc, And Ni/Sioc Catalytic Systems, Shavkat Tursunov, Askar Parmanov, Suvankul Nurmanov, Odiljon Ziyadullayev, Dilshod Boykobilov, Liudmila Khoroshko, Monika Wilamowska-Zawlocka, Balanand Santhosh, Olim Ruzimuradov

Turkish Journal of Chemistry

In this work, various aromatic monocarboxylic and dicarboxylic acids were subjected for the first time to a vinylation reaction with acetylene under heterogeneous catalytic conditions using catalytic systems based on silicon oxycarbide supported on silicon carbide (SiC): zinc silicon oxycarbide (Zn/SiOC), zinc oxide silicon oxycarbide (ZnO/SiOC), and nickel silicon oxycarbide (Ni/SiOC). The influence of the nature of the starting materials, temperature, reaction duration, solvent, and catalyst type on the yield of vinyl esters was investigated. The vinylation reaction of aromatic carboxylic acids with acetylene was carried out at 1:2 molar ratio, using a Zn/SiOC-50 catalytic system at a loading of …

Eco-Friendly Synthesis Of Carob- And Ginger-Modified Gold Nanoparticles For Enhanced Catalytic Applications, Muradi̇ye Şahi̇n, İlkay Hi̇lal Gübbük, Mustafa Ersöz

Turkish Journal of Chemistry

This study aimed to investigate the catalytic performance of gold nanoparticles (AuNPs) obtained by using ginger and carob antioxidant plants as reducing and stabilizing agents. In the first stage of the study, AuNPs were successfully produced using these herbal extracts via a green synthesis method, without the need for toxic chemicals, in a sustainable, economical, rapid, energy-efficient, and easy way. In the second stage, the structural analysis and catalytic applications of the obtained AuNPs were investigated. Advanced techniques such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), UV-Vis spectroscopy, and energy …

Association Between Fall Risk And Orthostatic Hypotension In The Elderly In A Skilled Nursing Facility, Pramod Srikant Kshirasagar

Doctorate in Kinesiology

Background: Orthostatic hypotension (OH) is an underrecognized contributor to falls among older adults, particularly in skilled nursing facilities (SNFs) where frailty, multimorbidity, and polypharmacy is common. Methods: Thirty-three SNF residents aged ≥65 years completed orthostatic testing after five minutes supine and at one and three minutes of standing. Fall and injury histories were extracted from records and resident reports. Analyses included nonparametric tests, logistic regression, receiver operating characteristic (ROC) analysis, and exploratory qualitative coding of injury descriptions. Results: Systolic and diastolic blood pressures decreased significantly from supine to standing (both p < .001). OH was more prevalent among fallers than non-fallers (96% vs 40%; χ2(1) = 12.68, p = .007). In logistic regression with OH as the outcome, fall history was strongly associated with OH (OR = 27.0, 95% CI [3.67–198.69], p = .001); ROC analysis showed excellent discrimination (AUC = 0.84, p = .029). The most frequently coded injuries were hip and femur fractures, followed by skin tears, head injuries, and humeral fractures (exploratory). Conclusions: OH is strongly linked to falls among SNF residents. Serial measurements at 1 and 3 minutes improved detection, supporting routine OH screening in fall risk assessment and proactive interventions (e.g., medication review, activity scheduling, and environmental safety).

Genetic Influences For Distinct Impulsivity Domains Are Differentially Associated With Early Substance Use Initiation: Results From The Abcd Study, Ethan Kinstler, Aaron J Gorelik, Sarah E Paul, Adamya Aggarwal, Emma C Johnson, Melissa A Cyders, Arpana Agrawal, Ryan Bogdan, Alex P Miller

2020-Current year OA Pubs

BACKGROUND: Impulsivity is among the strongest correlates of substance involvement (i.e. a broad continuum of substance-related behaviors), and distinct domains (e.g. sensation seeking [SS] and urgency) are differentially correlated, phenotypically and genetically, with unique substance involvement stages. Examining whether polygenic influences for distinct impulsivity domains are differentially predictive of early substance use initiation - a major risk factor for later problematic use - may improve our understanding of the role of impulsivity in addiction etiology.

METHODS: Data collected from participants of genetically inferred European ancestry enrolled in the Adolescent Brain Cognitive Development Study

RESULTS: SS-PGS was significantly associated with any …

Grenpoint Preservation L.P. V. Bennett

All Decisions

Handwritten opinion. This licensee holdover proceeding in a Project Based Section 8 building concluded with a stipulated settlement. The trial judge so-ordered the facts and determined the tenant, the deceased tenant's biological son, was eligible for succession. This was despite the tenant never being listed on the household composition, based on evidence of two years co-residency and a thwarted attempt by the landlord to add him. The court, relying on *Marine Terrace Associates v. Kesoglides*, found that an attempt by the landlord to add the successor, if rebuffed, along with familial relationship and co-residency, suffices for succession in the 2nd …

Ultra Vires Review Of Federal Agency Action Made Simple(R), Richard W. Murphy

Utah Law Review

The law governing ultra vires review seeking injunctive relief to challenge statutory violations by federal agencies is a mess. Although administrative law generally limits judicial review to final actions, a substantial body of caselaw holds that this type of ultra vires review can reach interlocutory actions, vastly expanding judicial reach. Although administrative law now insists that federal courts must exercise independent judgment when reviewing agency statutory interpretations, caselaw limits this type of ultra vires review to correcting only the most spectacular statutory violations. In addition, caselaw ignores or garbles the problem of determining which types of plaintiffs qualify to invoke …

Insights, Opportunities, And Challenges Provided By Large Cell Atlases, Martin Hemberg, Federico Marini, Shila Ghazanfar, Ahmad Al Ajami, Najla Abassi, Benedict Anchang, Bérénice A Benayoun, Yue Cao, Ken Chen, Yesid Cuesta-Astroz, Zachary Debruine, Calliope A Dendrou, Iwijn De Vlaminck, Katharina Imkeller, Ilya Korsunsky, Alex R Lederer, Jessica Jingyi Li, Pieter Meysman, Clint L Miller, Kerry A Mullan, Uwe Ohler, Pratibha Panwar, Nikolaos Patikas, Jonas Schuck, Jacqueline H Y Siu, Timothy J Triche, Alex Tsankov, Sander W Van Der Laan, Masanao Yajima, Jean Yang, Fabio Zanini, Ivana Jelic

Faculty, Staff and Student Publications

The field of single-cell biology is growing rapidly, generating large amounts of data from a variety of species, disease conditions, tissues, and organs. Coordinated efforts such as CZI CELLxGENE, HuBMAP, Broad Institute Single Cell Portal, and DISCO allow researchers to access large volumes of curated datasets, including more than just scRNA-seq data. These resources have created an opportunity to build and expand the computational biology ecosystem to develop tools necessary for data reuse and for extracting novel biological insights. We highlight achievements made so far, areas where further development is needed, and specific challenges that need to be overcome.

Alphasperm Data, Seth J. Parks, Timothy G. Jenkins

ScholarsArchive Data

Data from a prospective cohort study of sperm DNA methylation, semen analysis, and DNA fragmentation in fertile and infertile men before and after treatment with a male fertility antioxidant supplement.

Genome Editing Approaches To Harness Cytokinin–Salicylic Acid Crosstalk For Plant Protection, Muhammad Naseem, Khalid Muhammad

All Works

No abstract provided.

Height And Phytotelm Size Affect The Invertebrate Communities Of Epiphytic Bromeliads In The Amazon Rainforest, Xaali O'Reilly-Berkeley, Alex Pazmiño-Palomino, Andrea Hidalgo-Cárdenas, Sofía I. Trujillo-Regalado, Hannah Mossman, Jennifer K. Rowntree, Richard F. Preziosi

School of Biological and Marine Sciences

Tank bromeliads are found in rainforests across the Neotropics and harbour diverse invertebrate communities between their leaf axes. Various factors influence the invertebrate species richness and differences in composition in bromeliad phytotelmata, most notably, habitat size. However, there has been little work on invertebrate communities in bromeliads in western Amazonia or at different heights in the canopy. We collected 63 epiphytic bromeliads (Aechmea hoppii (Harms) L.B.Sm, A. nidularioides L.B.Sm) on the eastern edge of the Tropical Andes Biodiversity Hotspot in Ecuador and explored which biological and physical variables explained the differences in invertebrate composition among bromeliads. We extracted a total …

Biallelic Loss-Of-Function Variants In C19orf44 Lead To Retinal Degeneration, Hafiz Muhammad Jafar Hussain, Wang Meng, Yumei Li, Sabika Firasat, Mark E Pennesi, Michael B Gorin, Bin Guan, Rebecca Lynn Clark, Emma Fale-Olsen, Ranya Al Rawi, Aime Agather, Laryssa A Huryn, Paul Yang, Anna Matynia, Rui Chen

Faculty, Staff and Students Publications

Background: Inherited retinal diseases (IRDs) are a group of disorders often resulting in progressive vision loss, ultimately leading to blindness. A significant portion of their genetic causes remain unresolved, partly due to undiscovered disease-associated genes or variants. This study aimed to identify novel genetic links to IRDs.

Methods: All patients underwent comprehensive ophthalmological evaluation, including retinal imaging (fundus autofluorescence and macular optical coherence tomography) and electroretinogram testing. Whole exome sequencing and whole genome sequencing were performed on patients with clinically unsolved IRD, and data were analysed using an in-house pipeline to identify causal variants. Subsequently, Sanger sequencing was performed to …

The Symbiotic Harm Of A Criminal Record, Ericka B. Adams, Elsa Y. Chen, Sarah E. Lageson

Faculty Research, Scholarly, and Creative Activity

Having a criminal record significantly alters a person’s life chances, decreasing their opportunities for employment, housing, student loans, voting, public benefits, and more. The collateral consequences of criminal convictions, or the civil restrictions that follow criminal convictions, are well documented. However, because individuals are connected to families and communities, it is impossible to isolate the effects of punishment to only the persons holding criminal records. Instead, the effects of criminal records might be best understood as a set of symbiotic harms, marked by relational and interdependent effects. Drawing on semi-structured interviews with 59 expungement-eligible persons and 69 community representatives, this …

Socio-Scientific Issue-Based Challenge To Students' Chemical Literacy, Suratman S. Naim, La Kolo

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Chemistry has an important role in global challenges. Chemistry learning has not integrated an interdisciplinary approach to improving students' chemical literacy, enabling them to provide solutions to socio-scientific and environmental problems through the application of chemical concepts. This study aimed to determine the effect of the socio-scientific issues-based challenge strategy on students' chemical literacy. This study used a quantitative methods design with an embedded model. The sample consisted of tenth-grade students of SMA Negeri 1 East Halmahera in the 2025/2026 academic year from two sample classes. The experimental class was taught with the socio-scientific issues-based challenges strategy, while the control …

Home Coming Vistor Guide, Prairie View A&M University

Homecoming

No abstract provided.

Financial And Behavioral Health For Helping Professionals, Jeffrey Anvari-Clark

Books

This open access book brings together decades of research and practice on the intersections among financial and behavioral health concerns. By framing financial health as comprised of financial precarity, financial efficacy, and financial well-being, this new addition to the field of behavioral health helps readers understand and address the surge of interest in financial health and wellness from a holistic, psychosocial perspective. The text explores not only how financial difficulties impose hardship on individuals, couples, and families, but also how these concerns shape our feelings, perceptions, attitudes, and behaviors and thereby our health. Case examples throughout illustrate the concepts and …

Predator-Prey Population Distribution, Robert Robinette, April Sheppard

Staff and Faculty Scholarship

Determining the extent of the predatory publication problem at an R2 research university, Robert and April share their discoveries as well as how that impacts library services. This was presented at the Arkansas Library Association (ArLA) conference on October 19, 2025.

25 Conference Program - Enzyme Engineering Xxviii, John Woodley, Ditte Hededam Welner, Jens Erik Nielsen, Technical Liaison

Enzyme Engineering XXVIII

No abstract provided.

Impact Of Leadership Style On Climate And Culture, Tyler R. Mcnamara

Graduate Teacher Education

Abstract

This literature review studied the impact of transactional leadership, transformational leadership, democratic leadership, and autocratic leadership had on the climate and culture of schools. Specifically focused on the influence each leadership approach had on three components, teacher job satisfaction, teacher job performance, and student motivation. Culture and climate have leveraged retaining and recruiting quality teachers that can best educate students for the betterment of society. Research consisted of a collection made up of quantitative studies with two qualitative studies, taking place around the world in different countries, cultures, and religions. Results found transformational and democratic had the largest positive …

Home Range Size And Habitat Usage Of Hatchling And Juvenile Wood Turtles (Glyptemys Insculpta) In Iowa, Jeffrey W. Tamplin, Joshua G. Otten, Samuel W. Berg, Nadia E. Patel, Jacob B. Tipton, Justine M.R. Radunzel

Faculty Publications

The Wood Turtle (Glyptemys insculpta) is an endangered species in the state of Iowa and a species of conservation concern across their entire range. The Iowa population is characterized by high levels of adult and egg predation, displays little or no annual recruitment, and harbors an extremely low number of juveniles (7.3%). Home range and habitat usage studies of hatchling and juvenile Wood Turtles are limited to a few studies, and only one study of juveniles exists from the state of Iowa. Over a 10 yr period, we conducted a radiotelemetry study in Iowa on seven juvenile wood turtles for …

Heuristic Approaches For Coordinating Collaborative Heterogeneous Robotic Systems In Harvesting Automation With Size Constraints, Hyeseon Lee, Jung Yun Bae, Abhishek Patil, Myoungkuk Park, Vinh Nguyen

Michigan Tech Publications

Multi-agent coordination with task allocation, routing, and scheduling presents critical challenges when deploying heterogeneous robotic systems in constrained agricultural environments. These systems involve real-time sensing during their operations with various sensors, and having quick updates on coordination based on sensed data is critical. This paper addresses the specific requirements of harvesting automation through three heuristic approaches: (1) primal-dual workload balancing inspired by combinatorial optimization techniques, (2) greedy task assignment with iterative local optimization, and (3) LLM-based constraint processing through prompt engineering. Our agricultural application scenario incorporates robot size constraints for navigating narrow crop rows while optimizing task completion time. The …