Digital Commons Network^™

Surface Roughness And Microbial Adhesion On Four Provisional Prosthodontic Restorative Materials, Ola Al Hatem, Joe C Ontiveros, Donald M Belles, Maria D Gonzalez, Ransome Van Der Hoeven

Faculty, Staff and Student Publications

No abstract provided.

Ktrb-Mediated Alkaline Adaptation Drives Enterococcus Faecalis Persistence In The Gastrointestinal Tract Of Helicoverpa Zea, Patrick J. Hurd, Vivian Veto, Geneva Bell, Jerreme J. Jackson

Faculty Publications

Enterococcus faecalis is a commensal enteric bacterium capable of surviving in extreme and diverse environments. Here, we characterized the role of the gene ntpJ, which encodes the KtrB subunit of the KtrAB Na⁺/K⁺ symporter, during the adaptation of E. faecalis to alkaline stress and persistence in Helicoverpa zea (corn earworm). We assessed growth kinetics, biofilm formation, surface adhesion, and gastrointestinal persistence in vivo using an E. faecalis OG1RF mariner transposon mutant (ntpJ-Tn). The ntpJ-Tn mutant showed delayed entry into mid-log phase growth and biofilm formation under standard and alkaline-adjusted conditions relative to the wild-type strain, while adherence …

Pharmacological Profiling In Cll Patients During Pirtobrutinib Therapy And Disease Progression, Shady I Tantawy, Burcu Aslan, Ganiraju Manyam, Lakesla R Iles, Natalia Timofeeva, Neetu Singh, Nitin Jain, Alessandra Ferrajoli, Philip A Thompson, Keyur P Patel, Sai Prasad Desikan, William G Wierda, Varsha Gandhi

Faculty, Staff and Student Publications

No abstract provided.

The Volume And Characteristics Of Research On Gastrointestinal Symptoms In ‘Natural’ Peri- And Postmenopause:: A Scoping Review, Naomi Shaw, Rebecca Abbott, Clare Pettinger

School of Health Professions

BACKGROUND: Menopause has been linked to an array of symptoms, often with adverse effects on quality of life, work and relationships. Despite evidence of economic and social impacts, and a growing population of menopausal individuals, there are significant gaps in knowledge regarding menopause. Gastrointestinal (GI) symptoms in peri- and postmenopause are areas of uncertainty that warrant further investigation.

OBJECTIVES: Following JBI guidance, this scoping review aimed to systematically map research on GI symptoms in 'natural' peri- and postmenopause, exploring the volume and conduct of research, and variables investigated that could influence symptom experience.

ELIGIBILITY CRITERIA: Studies assessing GI symptoms (constipation, …

Cd5 Expression In Ctcl And Its Implications For Anti-Cd5 Car T-Cell Therapy, Leena Wardeh, Madeline Williams, Courtney Prestwood, Zachary Wolner, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

Cutaneous T-Cell Lymphomas (CTCL) are a heterogenous group of T-cell malignancies in the skin and have poor treatment outcomes in advanced stages. CD5, a surface glycoprotein expressed on most mature T cells, has emerged as a promising target for chimeric antigen receptor (CAR) T-cell therapy in systemic T-cell lymphomas. However, its expression profile in CTCL and relevance for targeted therapy remain unclear. Notably, in CTCL, the cell surface expression of receptors, such as CD7 and CD26, tends to become downregulated on the surfaces of malignant T cells In this study, we analyzed single-cell RNA sequencing (scRNA-seq) data from patients at …

A Novel Approach To Calculating Expected Total Fetal Lung Volume In Fetuses With Isolated Congenital Diaphragmatic Hernia And Fetal Growth Restriction: A Theoretical Computational Simulation, Morcos Hanna, Jonathan Davies, Amaryllis Fernandes, Pamela M Ketwaroo, Amy R Mehollin-Ray, Roopali Donepudi, Alice King, Joseph Hagan, Sundeep G Keswani, Sharada H Gowda, Caraciolo J Fernandes

Faculty, Staff and Students Publications

Objectives: Congenital diaphragmatic hernia (CDH) often coexists with fetal growth restriction (FGR). The observed-to-expected (O/E) total fetal lung volume (TFLV) is used to assess CDH severity, predict outcomes, and direct fetal interventions. Expected TFLV measurements traditionally rely only on gestation age (GA). This simulation assesses how incorporating weight-adjusted GA norms affects O/E TFLV calculations in patients with isolated CDH and FGR.

Methods: A simulated dataset (n=1,005) utilized published mean fetal weight and TFLV references. Computer-generated variables included observed weights (3rd-10th %ile), O/E TFLV (10-65 %), and percent liver herniation (0-42 %). GA estimates were corrected by weight and used to …

Signs, Symptoms, And Health-Related Quality Of Life In Melas: Measuring What’S Important From The Patient And Clinician Perspectives, Paolo Medrano, Benjamin Banderas, Marisa Brimmer, Lily Settel, Sari Berger, Alan Shields, Amy Goldstein, Amel Karaa, Austin Larson, Sumit Parikh, Fernando Scaglia, Karra Danyelle Harrington, Chris James Edgar, Pamela Ventola, Matthew Webster, Jennifer Chickering, Chad Gwaltney, Phebe Wilson, Chad Glasser

Faculty, Staff and Students Publications

Background and objectives: Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a rare genetic syndrome mostly associated with pathogenic variants in mitochondrial DNA. As there is limited research on the life experience of patients with MELAS, this study aimed to develop an understanding of the patient experience of MELAS through qualitative interviews to identify, describe, and substantiate important and relevant signs, symptoms, and health-related quality-of-life (HRQoL) impact (S/S/I) concepts.

Methods: Clinician and patient interviews were conducted virtually using semi-structured interview guides. During 60-minute interviews with five experts in the United States, clinicians were asked for their perspective on …

A Narrative Review Of Evidence, Safety, And Clinical Considerations In Taxane Chemotherapy For Pregnancy-Associated Breast Cancer, Jenny W. Zhang, Precious Ochuwa Imokhai, Danny Lee, Diana Hamdan, Trisha Mahajan, Satyam K. Singh, Amanda Brooks

Student Publications

The medical condition of pregnancy-associated breast cancer (PABC) requires oncologists to determine the best way to protect both the mother and the fetus during cancer treatment. The safety profile of taxanes, including paclitaxel and docetaxel, in the second and third trimesters of pregnancy remains unclear despite well-established anthracycline-based regimens (e.g., doxorubicin). High-risk breast cancer subtypes such as triple negative breast cancer (TNBC) and human epidermal growth factor receptor (HER2)-positive disease require taxane chemotherapy as standard treatment in nonpregnant patients. Objective: This paper aims to gather available data about the safety, timing and fetal outcomes related to taxane chemotherapy during PABC, …

Chimes: October 27, 2025, Calvin University

Chimes

Calvin's strategic planning process by Ashley Hamons

Public Health and Recreational Therapy programs phase out by Sarah Sparling

John Calvin's use of deception:A look at the French Reformation by McKenna Wilkinson

Men's soccer navigating roller coaster stretch, has eyes on MIAA tournament by Zach Kern & Hendrik Beelen

The hidden beauty of Calvin's organs by Ella Vanden Berg

Why 'religion'? A history of the department's name by Joe Toly

Resilience Factors And Physical Activity Engagement In Adolescents With Chronic Musculoskeletal Pain: A Cross-Sectional Study., William R. Black, Haley Hart, Jennifer Christofferson, Mark Connelly, Liesbet Goubert, Dustin Wallace, Laura Ellingson-Sayen, Ann M. Davis

Manuscripts, Articles, Book Chapters and Other Papers

Background/Objectives: Chronic musculoskeletal pain (CMSKP) affects up to 40% of adolescents and leads to substantial disability, reduced quality of life, and long-term health risks. Physical activity is central to treatment, but adherence to moderate-to-vigorous physical activity (MVPA) is inconsistent. We evaluated higher-resilience constructs-self-efficacy, pain acceptance, motivational stage, and affect-and hypothesized that higher resilience would be associated with greater objectively measured physical activity, better daily functioning, and higher quality of life in adolescents with CMSKP. Methods: Forty-three adolescents (13-18 years) with CMSKP completed measures of physical activity-specific self-efficacy, acceptance (AFQ-Y), motivational stage (PSOCQ-A), and affect (PANAS-C). Participants wore activPAL …

Managing Pcos In Adolescents, Michael Smith, Tania S. Burgert

Pediatrics in Practice: A CME Podcast

In this episode, Dr. Tania Burgert, a leading pediatric endocrinologist and director of the Multi-Specialty Adolescent PCOS Program at Children’s Mercy, breaks down the complexities of diagnosing and managing polycystic ovary syndrome (PCOS) in teens. She discusses the evolving diagnostic criteria, the challenges pediatricians face in early identification, and how to approach patients who may be “at risk.” Dr. Burgert also explores first-line treatment strategies, the critical role of mental health support, and how lifestyle interventions can be made sustainable for adolescents.

Click here to stream the podcast episode.

Resveratrol: A Promising Candidate For Treating A Range Of Diseases, Diaa El Din Ashraf Hemdan, Riham A. El-Shiekh

Bulletin of Faculty of Pharmacy Cairo University

Traditional Chinese Medicine (TCM), rooted in herbal remedies and balance, spans millennia, viewing illness as Qi imbalances. The therapeutic applications of resveratrol within the realm of TCM represent a fascinating intersection of ancient wisdom and modern scientific research. Resveratrol, a natural polyphenol commonly found in grapes, berries, and certain nuts, has emerged as a compound with diverse pharmacological properties that align closely with the principles of TCM. Resveratrol, ingrained in TCM, is esteemed for its health benefits like vitality and longevity. Resveratrol's pharmacological allure lies in antioxidant prowess, combating oxidative stress, and inflammation. It boasts cardioprotective traits, enhancing circulation and …

The Role Of Traditional Chinese Medicine (Tcm) In Battling Neurodegenerative Disorders, Diaa El Din Ashraf Hemdan, Riham A. El-Shiekh

Bulletin of Faculty of Pharmacy Cairo University

Aging and aging-related diseases pose significant challenges to global public health, necessitating the urgent development of effective anti-aging therapies. In this context, Traditional Chinese Medicine (TCM) emerges as a vital complementary and alternative approach to managing these conditions. Recent research has increasingly highlighted TCM's potential to slow the progression of aging and mitigate the effects of related diseases, including neurodegenerative disorders, cardiovascular diseases, diabetes, and cancer. The body of literature on TCM's role in addressing aging-related diseases has expanded considerably, revealing various mechanisms through which these ancient practices may exert their effects. TCM encompasses a rich array of herbal formulations …

Effects Of Foster Care Placement With Kin Or Nonkin On Opiate Abuse And Criminality, Pamela Bouyer

Walden Dissertations and Doctoral Studies

Opioid abuse has remained a public health crisis with far-reaching economic and social consequences that include costs associated with healthcare and increased foster care placements. Children placed into foster care are at risk themselves for opioid use and delinquency. The purpose of this quantitative research was to explore the causal-comparative relationship between foster care placement with kin (family) or nonkin (nonfamily) and its impacts on opiate abuse and criminal behavior. The Attachment Theory guided this study. Data were collected using a web-based, retrospective survey distributed at behavioral health agencies in Northeast Ohio, social media platforms, and Centiment, an online survey …

Parents’ Experiences With The Social-Emotional Development Of Toddlers With A Diagnosis Of Autism Spectrum Disorder After Completing Early Intervention, Veronica Bayer

Walden Dissertations and Doctoral Studies

The social-emotional development of autistic toddlers is a critical area of concern for parents and early childhood professionals. Parents need to understand how early intervention programs influence this development, as it can significantly impact long-term outcomes for children with autism. Grounded in the DIR (Developmental, Individual-differences, Relationship-based) theory by S. I. Greenspan and S. Wieder, the purpose of this basic qualitative study was to explore the experiences parents had with their autistic toddlers’ social-emotional development after completing an early intervention program. The participants comprised of eight parents whose toddlers completed an early intervention program and were later diagnosed with autism. …

Educator Perceptions On Preparing Students For A Biology I State Assessment, Lila Grooms

Walden Dissertations and Doctoral Studies

The problem addressed through this study was that 9th and 10th grade students’ Biology I state assessment scores continued to decline in a suburban South Carolina school district. The purpose of this basic qualitative study was to explore biology teachers’ perceptions of the low success rates on the Biology I state assessment and to identify recommendations for improvement. Vygotsky’s social constructivism theory provided the conceptual framework, emphasizing the role of social engagement and collaborative learning environments. Semistructured interviews with nine high school biology teachers were conducted and using Braun and Clark’s thematic analysis approach. Themes revealed that teachers are: (a) …

Shared Family Identity And Emotional Abuse From A Childhood Caregiver As Predictors Of Self-Censorship Willingness, Jillian Theryon

Walden Dissertations and Doctoral Studies

Childhood emotional abuse may be underreported and unnoticed. The purpose of this quantitative cross-sectional study was to examine whether shared family identity (SFI) with an emotionally abusive childhood caregiver was linked to self-censorship of social and political opinions in adulthood. The study also examined whether this relationship is intensified among those with a strong sense of SFI with that caregiver. Linear multiple regression analysis of survey data collected from 119 participants, recruited through Survey Monkey Audience, revealed that willingness to self-censor was significantly shaped by the interaction between SFI and emotional abuse, especially overcontrol. Although SFI is often seen as …

Fall 2025 Its Issues On Campus (White Paper), Barbara Carlsward, Brad Decker, Elizabeth Peterson

Faculty Senate Reports

This white paper compiles the host of issues faced by faculty in the Fall 2025 semester rollout. This document was shared with ITS Director Ryan Gibson and VPBA Matt Bierman.

Fall 2025 Its Issues On Campus (Slides), Barbara Carlsward, Brad Decker, Elizabeth Peterson

Faculty Senate Reports

This document is a PDF of the slides highlighting campus ITS issues experienced by faculty and students in the Fall 2025 semester rollout.

The Consciousness Inherent In Chasing Your Tail, Sergio M. Pellis Dr.

Animal Sentience

Who is conscious and how do we know? Complexity in behavior and cognition is certainly a clue that cannot be ignored in identifying this trait, and as Mather’s target article shows, it is hard not to imagine consciousness arising in cephalopods. But how complex is complex? An alternative may be gleaned from the fact that all living things rely on negative feedback to navigate their worlds, and this requires all sentient beings knowing what is to be stabilized in reflection to themselves. If so, consciousness is a universal trait.

The Term Consciousness And Impressive Evidence For Cephalopod Awareness, Donald M. Broom

Animal Sentience

Mather presents comprehensive evidence of cephalopod cognitive ability and of a high level of awareness. The importance of taking account of the biological functioning and adaptations to the living environment is emphasised. An argument is presented that it is better to limit the use of the word conscious to ‘not unconscious’ and to use awareness in relation to the various levels of cognitive functioning.

Female Cardioprotection In A Mouse Model Of Alcohol-Associated Cardiomyopathy, Joshua M. Edavettal, Meagan Donovan, Nicholas R. Harris, Xavier R. Chapa-Dubocq, Keishla M. Rodríguez-Graciani, Janos Paloczi, Liz Simon, Bysani Chandrasekar, Jason D. Gardner

School of Graduate Studies Faculty Publications

Chronic alcohol misuse is the leading cause of non-ischemic dilated cardiomyopathy, and the molecular mechanisms underlying the development of alcohol-associated cardiomyopathy (ACM), particularly regarding sex-specific susceptibility and mitochondrial contributions, are not fully known. In this study, we utilized a preclinical model of chronic + binge ethanol consumption to investigate sex differences in disease severity and mitochondrial function. Male and female C57BL/6J mice were fed ethanol or control liquid diets for 30 days, with 2 binge episodes on days 10 and 30. Cardiac morphology was assessed via echocardiography and cardiac function via left ventricular pressure-volume catheterization. Mitochondrial function was evaluated ex …

Comparative Analysis Of Citrate Synthase Activity In Skeletal Muscle, Liver, And Adipose Tissue In Beef Cattle, Abigail Webb

Honors Program: Senior Projects (Public)

Mitochondrial efficiency plays a central role in determining how cattle partition nutrients toward muscle growth or adipose deposition, yet little is known about tissue-specific differences in mitochondrial density among tissues or among beef cattle. This study aimed to quantify mitochondrial density in muscle, liver, and adipose tissue samples from beef cattle and evaluate its potential relationship with metabolic efficiency. Tissue samples of semitendinosus muscle (ST), liver, and subcutaneous adipose (SC) were collected, homogenized, and analyzed for citrate synthase (CS) activity using a fluorometric assay as a proxy for mitochondrial density. Preliminary analyses revealed that the semitendinosus muscle displayed the highest …

Clinicians’ Perceptions Of Restorative Justice And Community-Based Intervention Programs For Juvenile Offenders, Jacque Timberlake

Walden Dissertations and Doctoral Studies

The main goals of restorative justice and community-based intervention programs include reducing reoffending behavior, successful reintegration, and yielding greater satisfaction among participants. Although clinicians play a vital role in conducting rehabilitation methods for youth offenders, the problem was a lack of literature that explored clinicians’ perceptions of implementing more effective alternatives such as restorative justice and community-based intervention programs. The purpose of this generic qualitative study was to explore clinicians’ perceptions of administering rehabilitative interventions for youth offenders, specifically in reducing recidivism, adequately addressing mental health concerns, and evaluating overall program effectiveness. The risk-need responsivity model and the good lives …

Artistic Illustrations In Bi Monthly Journal “Jeta E Re” During The Years 1970–1973, Milot Gusia

UBT International Conference

This research examines the contribution of twelve Albanian artists in bi monthly journal on literature “Jeta e Re” during the period of the years 1970-73. Drawing from 18 issues that were published by the Kosovar publishing journal “Jeta e Re”, this research tries to uncover the artistic styles and illustrations that prevailed in the printed matters of the forementioned period. The issues were uncovered in the archives of the National Library of Kosova mainly presented in the form of drawings, etchings and rare painting reproductions in black and white printing. Because the journal “Jeta e Re” was focused mainly on …

Apitherapy: Therapeutic Potential Of Bee Products In Human Health, Vezir Januzi, Albina Jaha, Hyzer Rizani, Nexhat Balaj

UBT International Conference

Apitherapy is a form of alternative medicine based on the therapeutic use of bee products, such as honey, propolis, royal jelly, pollen, beeswax, and bee venom. These substances have been used for centuries in traditional medicine for their documented antimicrobial, anti-inflammatory, and anti-allergic properties. With the development of biomedical sciences and interest in natural treatments, apitherapy is gaining increasing attention in contemporary medicine. This study aims to review the local and international scientific literature on the impact of apitherapy on human health. The analysis focuses on the findings of experimental and clinical research evaluating the preventive and therapeutic effects of …

The Impact Of Chemical Parameters Of Surface Water Quality In Prizren And Sources Of Pollution, Sami Gashi, Vehebi Sofiu, Nexhat Balaj, Besar Veseli

UBT International Conference

Our study investigates several chemical indicators of pollution whose parameters have negative impacts on surface water quality in Prizren, focusing on several seasonal months and identifying pollution sources. During a one-year period, water samples were taken at key locations, in the Lumbardh River of Prizren, to analyze several parameters such as pH, dissolved oxygen (DO), biochemical oxygen demand (BOD5), chemical oxygen demand (COD), total dissolved solids (TDS). Surface water quality is subject to more frequent pollution of these parameters especially in different months of the year and were closely monitored to understand their impact on water quality during droughts. The …

Impacts Of Pesticides And Herbicides On Air, Soil, And Water Ecosystems, Ibush Luzha, Smajl Rizani, Jehona Luzha Beqiraj

UBT International Conference

Pesticides and herbicides, widely used agents in modern agriculture and environmental management for controlling pests and weeds, contribute to increased food production. However, their massive and often uncontrolled use has raised serious concerns about negative impacts on natural ecosystems. This paper comprehensively analyzes their effects on three key environmental components: air, soil, and water. In terrestrial ecosystems, these chemicals alter microbial biodiversity, harm beneficial organisms such as earthworms and pollinating insects, reduce soil fertility, and persist and bioaccumulate. In aquatic ecosystems, they contaminate surface and groundwaters through runoff, leaching, and atmospheric deposition, cause acute and chronic toxicity to aquatic organisms …

An Overview On Chemical Profile For Oil And Alcholic Tinctures Of Rosmarinus Officinalis Plants, Blerina Xhaferaj, Anila Kripa, Sokol Kocia, Lindita Vrushi, Kozeta Vaso, Aurel Nuro

UBT International Conference

This study shown data on chemical profile for oil and alcoholic tinctures of Rosmarinus officinalis cultivated populations from Durres area. Rosemary is an essential perennial aromatic, evergreen shrub belonging to the family Lamiaceae and indigenous to the Mediterranean region. This plant has branches full of green leaves that exude a characteristic fragrance. For this is widely used in culinary. Rosemary is used since ancient times in traditional medicine because of its vital health effects. Rosemary is a popular and versatile, medicinal plant, and is often used in tinctures and other home remedies. It can be used to treat respiratory infections, …

Consanguinity And Rare Genetic Disorders: Epidemiology, Case Studies, And Clinical Implications, Yllka Gashi, Anjeza Temaj, Erda Aliu, Sefedin Bilalli, Driton Selmani, Gazmend Temaj, Nexhibe Nuhi

UBT International Conference

Consanguinity, defined as reproductive unions between closely related individuals, considerably increases the probability of offspring inheriting rare autosomal recessive (AR) disorders. This review explores the effects of consanguinity on the incidence, complexity, and spectrum of inherited diseases, emphasizing rare genetic syndromes within diverse populations. Consanguinity rates vary significantly by region, directly influencing the prevalence of founder mutations and specific AR diseases. In-depth literature review and case analyses—including Joubert syndrome, mucopolysaccharidoses (MPS), epidermolysis bullosa (EB), and systemic lupus erythematosus (SLE)—underscore the increased phenotypic and genotypic heterogeneity within affected groups, often resulting in blended or unusually severe disease manifestations. Recent molecular techniques, …