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Articles 3541 - 3570 of 31379
Full-Text Articles in Entire DC Network
Religion's Role In Shaping Psychopathological Narratives, Andrea Gonzalez Mendoza
Religion's Role In Shaping Psychopathological Narratives, Andrea Gonzalez Mendoza
The Graduate Review
Understanding the interplay between religion and psychopathology is essential for clinicians navigating the complexities of mental health diagnosis and treatment. This paper explores the nuanced relationship between belief systems and diagnostic frameworks, shedding light on how religious beliefs influence the perception, assessment, and treatment of mental disorders. Drawing upon historical and current-day research, this paper examines how religious interpretations shape the presentation and understanding of psychopathological symptoms. In doing so, this paper argues that psychopathology cannot be understood without considering the influence of religion on its conceptualization. The latter is illustrated by looking at historical diagnostic patterns and how they …
Pearl Buck’S Humanitarian Vision In War And Peace, David M. Crowe
Pearl Buck’S Humanitarian Vision In War And Peace, David M. Crowe
Presidential Fellows Articles and Research
"Eurasia, that vast continental region that encompasses Europe and Asia, was a tablet for many of Pearl S. Buck’s works and campaigns for human rights and international efforts to improve the human condition globally. Though she is principally known for her works on China, some scholars, while acknowledging that her novels were principally for an American female audience, gave little attention to her significant body of non-fictional works on a variety of subjects on America and East Asia. I made my first trip to China in the summer of 1985 via the Trans-Siberian Railroad and Mongolia to Beijing."
Sunburned Plankton: Ultraviolet Radiation Inhibition Of Phytoplankton Photosynthesis In The Community Earth System Model Version 2, Joshua Coupe, Nicole S. Lovenduski, Luise S. Gleason, Michael N. Levy, Kristen Krumhardt, Keith Lindsay, Charles Bardeen, Clay Tabor, Cheryl Harrison, Kenneth G. Macleod, Siddhartha Mitra, Julio Sepúlveda
Sunburned Plankton: Ultraviolet Radiation Inhibition Of Phytoplankton Photosynthesis In The Community Earth System Model Version 2, Joshua Coupe, Nicole S. Lovenduski, Luise S. Gleason, Michael N. Levy, Kristen Krumhardt, Keith Lindsay, Charles Bardeen, Clay Tabor, Cheryl Harrison, Kenneth G. Macleod, Siddhartha Mitra, Julio Sepúlveda
Faculty Publications
Ultraviolet (UV) radiation can damage DNA and kill cells. We use laboratory and observational studies of the harmful effect of UV radiation on marine photosynthesizers to inform the implementation of a UV radiation damage function for phytoplankton photosynthesis in a modified version of the Community Earth System Model version 2 (CESM2-UVphyto). CESM2-UVphyto is capable of simulating UV inhibition of photosynthesis among modeled phytoplankton and ocean column penetration of UV-A, UV-B, and UV-C radiation. We conduct a series of simulations with CESM2-UVphyto using the Marine Biogeochemistry Library (MARBL) ecosystem model to understand the sensitivity of phytoplankton productivity to UV radiation. Results …
The Perceptions Of Foster Care Alumni Who Are Recipients Of Pandemic Aid, Ashley Robinson
The Perceptions Of Foster Care Alumni Who Are Recipients Of Pandemic Aid, Ashley Robinson
Walden Dissertations and Doctoral Studies
The COVID-19 pandemic heightened challenges for young adults transitioning from foster care to independence. Research shows that foster care alumni faced barriers in education, employment, housing, and health due to limited support networks. Yet, little is known about how emergency policies, such as the Consolidated Appropriations Act (CAA) of 2021, affected them. The purpose of this qualitative study was to explore the perceptions and experiences of foster care alumni who received financial aid through the Act. The research question: What were the experiences and perceptions of foster care alumni (aged 18-26) who received funds via the CAA of 2021 during …
How Plants Defy Gravity, Olivia Y. Kim, Agatha Shaikhutdinova, Joshua Lee, Reece Sit, Daniel Yang, Aliyah Shams, Kathryn Choi, Esther Yoo
How Plants Defy Gravity, Olivia Y. Kim, Agatha Shaikhutdinova, Joshua Lee, Reece Sit, Daniel Yang, Aliyah Shams, Kathryn Choi, Esther Yoo
STEM for Success Showcase
This educational short book, written by students, uses creative descriptions to make biology and chemistry concepts engaging and easy to understand.
November 5, 2025 Faculty Senate Minutes, University Of South Carolina
November 5, 2025 Faculty Senate Minutes, University Of South Carolina
Faculty Senate
No abstract provided.
Let It Flow: Walking-With Educators In Affective School Environments, Alyssa Dominique Nucaro
Let It Flow: Walking-With Educators In Affective School Environments, Alyssa Dominique Nucaro
Electronic Theses and Dissertations Archive
This dissertation explores the intertwined relationships between K–5 educators and the external environments of their schools. Drawing on post-qualitative inquiry, the study rejects traditional linear methodologies in favor of walking-with, a practice of movement, noticing, and attunement that foregrounds affective intensities and material encounters. Through walking-with, artifact-based reflections, and journaling, this research maps how teachers experience, interpret, and are shaped by the spaces that surround their schools. The dissertation presents vignettes and poetic fragments as affective offerings that illuminate how space, pedagogy, and community intermingle. These moments reveal tensions and possibilities around safety, visibility, infrastructure, play, and cultural connection, while …
Queens, Care, And Creativity: Exploring The Expressions Of Othermothering By African American Girls, Lischa Tshoiya Brooks
Queens, Care, And Creativity: Exploring The Expressions Of Othermothering By African American Girls, Lischa Tshoiya Brooks
Electronic Theses and Dissertations Archive
This study explores othermothering as a cultural and political practice among African American girls in Memphis, Tennessee. While most scholarship on othermothering centers the voices of adult women, this research foregrounds the perspectives of African American girls, illuminating how they interpret and experience the influence of othermothers on their identity formation. Guided by Black Feminist Thought, Africana Womanism, and arts-based inquiry, the study situates othermothering as a theoretical framework that is both intimate and political by nurturing personal growth while resisting deficit narratives that marginalize Black girlhood. Data were collected through a creative workshop, Walk Like a Queen Crown Workshop, …
Ethnobotanical Surveys And Morphological Analysis Of Medicinal Plant Names In Lɔ́Mɔngo (Lomongo) C60 At The Elandisha Mavaolo Protected Area In Northeastern Democratic Republic Of Congo, Jean-Baptiste Grodya Musafiri, Jean-Bosco Njango Ngonda, Reddy Shutcha Ehata, Charles Kumbatulu Sita, Chrispina Alphonce, Helene B. Mavar Manga Sodila
Ethnobotanical Surveys And Morphological Analysis Of Medicinal Plant Names In Lɔ́Mɔngo (Lomongo) C60 At The Elandisha Mavaolo Protected Area In Northeastern Democratic Republic Of Congo, Jean-Baptiste Grodya Musafiri, Jean-Bosco Njango Ngonda, Reddy Shutcha Ehata, Charles Kumbatulu Sita, Chrispina Alphonce, Helene B. Mavar Manga Sodila
Journal of Humanities and Social Sciences
The aim of this research is to contribute to the documentation of Lomongo, a Bantu language spoken in the Democratic Republic of Congo (DRC). In this study, we focused on two morphological aspects of medicinal plant names in Lomongo: nominal morphology and morpho-syntax. To collect data, we engaged with two categories of informants: primary informants (traditional healers) and secondary informants (native Lomongo speakers). Ethnobotanical and ethnolinguistic surveys were conducted in the “Elandisha” Mavaolo area through participant observation, semi-structured interview guides, audio recordings, and photographs. The plants identified were documented in situ with the assistance of botanists from "Matiti-Lisanga," an interdisciplinary …
Decoding Omens From Animal Calls And Sightings: An Ethnozoolinguistic Study Among The Iraqw Of Tanzania, Chrispina Alphonce
Decoding Omens From Animal Calls And Sightings: An Ethnozoolinguistic Study Among The Iraqw Of Tanzania, Chrispina Alphonce
Journal of Humanities and Social Sciences
Understanding the interplay between cultural beliefs, language, and environmental signals is crucial for comprehending how communities engage with their natural surroundings. Despite existing research on cultural interpretations of natural phenomena, little is known about how animal calls and sightings specifically predict omens within the Iraqw community in Tanzania. This study examines the Iraqw ethnozoolinguistics of omens, focusing on their role in forecasting social events, both positive and negative, and on how these signals reflect the community’s cultural understanding. A qualitative research design was employed, with data collected through introspection, focus group discussions, and semi-structured interviews, grounded in ecosemiotic, ecolinguistic, and …
What Is In A Plant Name? A Semantic Analysis Of Indigenous Plant Names Among The Yao Of Southern Tanzania, Julius John Taji
What Is In A Plant Name? A Semantic Analysis Of Indigenous Plant Names Among The Yao Of Southern Tanzania, Julius John Taji
Journal of Humanities and Social Sciences
This study investigates the meanings conveyed by indigenous plant names among the Yao of Masasi, southern Tanzania, whose native language is Chiyao (Bantu, P21). The study specifically explores what plant names communicate beyond functioning as tools for labelling and identifying. The data for the study were collected through semi-structured interviews and jungle-walk-and-identify methods and they were analysed using the framework of onomastics, particularly the area of phytonyms. The sample of the study consisted of nine native speakers of Chiyao from three villages in the Masasi District in Tanzania, namely Chiwata, Kanyimbi and Mkululu. The findings show that indigenous plant names …
Investigating The Plant Folk Taxonomy In The Bena Language Of Tanzania, Adriano Utenga
Investigating The Plant Folk Taxonomy In The Bena Language Of Tanzania, Adriano Utenga
Journal of Humanities and Social Sciences
This paper surveys plant identification and categorisation among the Bena. Each society’s cultural uniqueness and peculiarity in categorising the local biodiversity informed the study. The researcher conducted the study in Lupembe Ward, Njombe District Council, where Bena is the predominant language. Five elderly speakers of Bena, knowledgeable about plants, were selected through purposive and snowball sampling techniques. Jungle-walk-and-identify and focus group interviews were the key methods for data collection. Using the Perceptual-Taxonomic Theory as a guide, I analysed the data thematically. The study found that the Bena cannot identify the unique beginner “plant” (the all-inclusive word for the notion plant). …
Investigating The Relationship Between Noun Classes And Plant Folk Taxonomy In Chasu Language Of Kilimanjaro Region In Tanzania, Peter Rabson Mziray
Investigating The Relationship Between Noun Classes And Plant Folk Taxonomy In Chasu Language Of Kilimanjaro Region In Tanzania, Peter Rabson Mziray
Journal of Humanities and Social Sciences
The current study investigates the relationship between noun classes and plant folk taxonomy in Chasu (G 22). The study focuses on two objectives: the first objective is to describe the plant folk taxonomy in Chasu and the second objective is to determine the relationship between noun classes and plant folk taxonomy in Chasu. Data were collected from rural villages in Same and Mwanga districts by using free listing, field interviews (jungle-walk-and-identify), and written texts containing Chasu plant names. The findings reveal that Chasu folk taxonomy reflects different ethnobotanical categories; including a unique beginner which is mmea/mimea ‘plant(s)’, and three life …
Low Dose Cone Beam Computed Tomography Versus High Dose Cone Beam Computed Tomography In Measuring Furcation Involvements: (Diagnostic Accuracy Study), Marwa Ezz, Cairo University, Misr University For Science & Technology
Low Dose Cone Beam Computed Tomography Versus High Dose Cone Beam Computed Tomography In Measuring Furcation Involvements: (Diagnostic Accuracy Study), Marwa Ezz, Cairo University, Misr University For Science & Technology
Dentistry
Accurate diagnosis of furcation defect is essential in periodontal therapy planning. Cone beam computed tomography (CBCT) provides three-dimensional visualization, but higher radiation doses remain a concern. This study aims to assess and compare the diagnostic accuracy of low-dose CBCT (LD-CBCT) and high-dose CBCT (HD-CBCT) in detecting and measuring furcation defect using a pig mandible. Detection and accurate assessment of periodontal disease is important to determine the tooth prognosis and treatment. Radiographic assessment provides information about the pattern and extent of the furcation defect. CBCT provides unique 3D images used for diagnosis and treatment plans, but its use in periodontology not …
Computational Data Analysis, Kathryn S. Biles
Computational Data Analysis, Kathryn S. Biles
LSU Master's Theses
Data science has emerged as a cornerstone of innovation, shaping an ever-expanding range
of professional careers. As technology advances and the volume of data expands expo-
nentially, the ability to extract meaningful insights from data has become indispensable
across industries. Far from representing a single career path, data science enables profes-
sionals in nearly every domain to make informed decisions, optimize systems, and drive
innovation. Yet, many high school students and incoming college freshmen have limited
exposure to data science fundamentals or the career opportunities they unlock. This is
the gap that Computational Data Analysis, a high school-level curriculum I …
Development Of A Clinically Relevant Rabbit Model Of Acute Laryngeal Injury, Ryan Stepp, Naushin Ali, Areli A. Rodriguez, Ethan Nicklow, Noah Thornton, Adithya Reddy, Hannah L. Kenny, Patrick S. Cottler, Donald R. Griffin, James J. Daniero
Development Of A Clinically Relevant Rabbit Model Of Acute Laryngeal Injury, Ryan Stepp, Naushin Ali, Areli A. Rodriguez, Ethan Nicklow, Noah Thornton, Adithya Reddy, Hannah L. Kenny, Patrick S. Cottler, Donald R. Griffin, James J. Daniero
Department of Otolaryngology - Head and Neck Surgery Faculty Papers
OBJECTIVES: Acute laryngeal injury (ALgI) is created as a result of endotracheal tube pressure ulcer formation leading to fibrosis and inflammation. This condition often leads to airway obstruction and voice and swallowing dysfunction. This study demonstrates a reliable animal model of ALgI to reproduce the acute wound process seen clinically, to explore the pathophysiology of this disease process, and to serve as a reproducible injury suitable for the evaluation of therapeutic interventions.
METHODS: An ALgI model was developed in New Zealand White rabbits using precise mucosal stripping of the posterior larynx, followed by intubation with an oversized 4.0 endotracheal tube …
Data Accompanying "Landscape Composition Surrounding Restoration Projects Modulates Use By Wildlife: A Case Study Of Mule Deer In Utah", Jaylin Solberg
Data Accompanying "Landscape Composition Surrounding Restoration Projects Modulates Use By Wildlife: A Case Study Of Mule Deer In Utah", Jaylin Solberg
Browse all Datasets
With mule deer (Odocoileus hemionus), hereafter, deer, populations in decline, wildlife managers have increased their efforts to improve factors that limit population growth. In the State of Utah (hereafter, Utah), these efforts have included habitat restoration which is expected to improve environmental conditions for deer. Some of these efforts include pinon-juniper removal, prescribed burning, and spraying of invasive plant species. Although previous work has demonstrated the local impacts of restoration on deer populations, it is unknown how the environmental conditions in the landscape surrounding restoration treatments may modify local restoration impacts. Identifying how both local and landscape-scale conditions influence deer …
Circulating Levels Of Insulin-Like Growth Factor I (Igf-I) And Risk Ofmultiple Myeloma: An Observational And Mendelian Randomisation Study, Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa I. Clay-Gilmour Ph.D., Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qing Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Shaji J. Kumar, Et. Al.
Circulating Levels Of Insulin-Like Growth Factor I (Igf-I) And Risk Ofmultiple Myeloma: An Observational And Mendelian Randomisation Study, Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa I. Clay-Gilmour Ph.D., Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qing Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Shaji J. Kumar, Et. Al.
Faculty Publications
Evidence for an association between insulin-like growth factors (IGF) and multiple myeloma (MM) is inconsistent. We examined total IGF-I concentrations and risk of MM by combining baseline serological data among UK Biobank participants (n = 444 187; 732 incident MM) with a two-sample Mendelian randomisation (MR) analysis using identified genetic variants associated with circulating total IGF-I and IGF-binding protein 3 (IGFBP-3) in the InterLymph consortium (2434 MM and their 2567 controls). Finally, additional lymphoid neoplasm (LN) subtypes were included for comparison with the main hypothesis. Circulating IGF-I level was positively associated with MM risk Hazard ratio-HR-per one standard deviation-SD-increase …
Leveraging Dna Methylation Profiling And Microrna Sequencing To Characterize The Epigenomic Landscape Of Major Depressive Disorder Disease Trajectory, Jan Dahrendorff
Leveraging Dna Methylation Profiling And Microrna Sequencing To Characterize The Epigenomic Landscape Of Major Depressive Disorder Disease Trajectory, Jan Dahrendorff
USF Tampa Graduate Theses and Dissertations
Major depressive disorder (MDD) is a common and debilitating mental disorder associated with a significant disease burden and economic cost. Despite ample evidence documenting the efficacy of a diverse array of established MDD therapies, a large proportion of patients are inadequately responsive to initial treatment attempts, with first-line treatments leading to remission in only ~30% of the patients. Importantly, about a third of patients even fail to achieve symptom improvement after two or more antidepressant trials, resulting in what is commonly defined as treatment-resistant depression (TRD). The ability to identify which treatments are most likely to elicit a positive response …
A Multi-Faceted Study Of Antibiotic-Resistant, Opportunistic Pathogens In Wastewater And Environmental Water, Jeanette Calarco
A Multi-Faceted Study Of Antibiotic-Resistant, Opportunistic Pathogens In Wastewater And Environmental Water, Jeanette Calarco
USF Tampa Graduate Theses and Dissertations
More than 2.8 million infections due to antibiotic-resistant bacteria occur annually in the United States, and more than 35,000 people die as a result. Domestic wastewater (sewage), which contains antibiotic-resistant bacteria and antibiotic resistance genes, is collected at treatment plants for removal of contaminants, e.g. pathogenic microorganisms and nutrients. While wastewater treatment is designed to remove antibiotic-resistant bacteria and other microorganisms through treatment and disinfection, some bacteria may escape treatment. Treated wastewater effluent is generally discharged into surface waters; however, some fraction of the effluent may be used as recycled water. Compromised wastewater collection infrastructure and sewage spills can disseminate …
From Specialized To Generalized Frameworks: Broadening Machine Learning Approaches To Detect Natural Selection, Sandipan Paul Arnab
From Specialized To Generalized Frameworks: Broadening Machine Learning Approaches To Detect Natural Selection, Sandipan Paul Arnab
Electronic Theses and Dissertations
Natural selection leaves characteristic footprints in genomic variation, and detecting these patterns is fundamental to understanding evolutionary history and adaptation in humans. In this thesis, I present a progression of machine learning frameworks, beginning with highly specialized feature engineering and complex modeling, advancing to approaches that require minimal training, and culminating in methods that remain robust to model misspecification. First, I developed SISSSCO, a spectral feature extraction framework that applies wavelet transforms, multitaper analysis, and S-transform to genomic summary statistics, converting one-dimensional signals into two-dimensional spectral images analyzed by convolutional neural networks. SISSSCO achieved high accuracy across varied evolutionary scenarios, …
Cofilin Inhibition Ameliorates Piezo2 And Ampa Dysfunction In A Mouse Model Of Angelman Syndrome, Luis O Romero, Manisha Bade, Elisa Carrillo, Sonia Paz-López, Syed A M Hasan, William James Antonisamy, Vasanthi Jayaraman, Zahoor A Shah, Valeria Vásquez, Julio F Cordero-Morales
Cofilin Inhibition Ameliorates Piezo2 And Ampa Dysfunction In A Mouse Model Of Angelman Syndrome, Luis O Romero, Manisha Bade, Elisa Carrillo, Sonia Paz-López, Syed A M Hasan, William James Antonisamy, Vasanthi Jayaraman, Zahoor A Shah, Valeria Vásquez, Julio F Cordero-Morales
Faculty, Staff and Student Publications
Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported in dorsal root ganglia (DRG) neurons, along with impaired mechanosensitive ion channel activity. Currently, there are no pharmacological targets to prevent the decrease of F-actin in AS. Here, we utilize a first-in-class selective cofilin inhibitor (SZ-3) to restore PIEZO2 function in DRG neurons and glutamate-evoked currents in hippocampal neurons from AS mice. Using atomic force microscopy, we demonstrate that inhibiting cofilin, an actin-severing protein, with SZ-3 increases cellular stiffness by stabilizing the actin …
Integrating Pathogenic Variants, Polygenic Risk Score, And Family History For Prostate Cancer Risk Estimation In Men Of African Ancestry, Fei Chen, Xin Sheng, Anqi Wang, Yili Xu, Raymond Hughley, Wei Xiong, Loreall Pooler, Peggy Wan, Susan M Gundell, Godfrey Kigozi, Gertrude Nakigozi, Fred Nalugoda, Joseph Kagaayi, Grace Nalwoga Kigozi, Stephen Mugamba, Emmanuel Kyasanku, James Nkale, Vitalis Ofumbi Olwa, Alexander Lubwama, Alex Daama, Resty Nakajugo, Ben Adusei, Mohamed Jalloh, Serigne Magueye Gueye, Andrew A Adjei, James Mensah, Pedro W Fernandez, Akindele Olupelumi Adebiyi, J Olufemi Ogunbiyi, Oseremen Inokhoife Aisuodionoe-Shadrach, Lindsay Petersen, Wenlong Carl Chen, Jo Mcbride, Jeannette T Bensen, James L Mohler, Jack A Taylor, Caroline Andrews, Mbaaga Kigongo, Amanya Colline, Vicky Kiddu, Juliet Namugambe, Shallot Owamaani, Kuteesa Job, Benon Joseph Masaba, Frank Asiimwe, Proscovia Muwanga, Joy Namulondo, Florence Nagawa, Charity Kayiraba, Martin Ogwang, Ronald Okidi, David Oweka, Elio Kitara, James Obonyo, Daniel Lajul, Paul Matovu, Precious Arinda Muheki, Johnson Natumanya, Emmanuel Agaba, Emmanuel Aculokin, Amos Twongyeirwe, George Mutema, Denis Bitamazire, Eboneé N Butler, Sue Ann Ingles, Benjamin A Rybicki, Janet L Stanford, Wei Zheng, Sonja I Berndt, Stephen J Chanock, Chad D Huff, Joseph Lachance, Luc Multigner, Burcu F Darst, Timothy R Rebbeck, Laurent Brureau, Stephen Watya, David V Conti, Christopher A Haiman
Integrating Pathogenic Variants, Polygenic Risk Score, And Family History For Prostate Cancer Risk Estimation In Men Of African Ancestry, Fei Chen, Xin Sheng, Anqi Wang, Yili Xu, Raymond Hughley, Wei Xiong, Loreall Pooler, Peggy Wan, Susan M Gundell, Godfrey Kigozi, Gertrude Nakigozi, Fred Nalugoda, Joseph Kagaayi, Grace Nalwoga Kigozi, Stephen Mugamba, Emmanuel Kyasanku, James Nkale, Vitalis Ofumbi Olwa, Alexander Lubwama, Alex Daama, Resty Nakajugo, Ben Adusei, Mohamed Jalloh, Serigne Magueye Gueye, Andrew A Adjei, James Mensah, Pedro W Fernandez, Akindele Olupelumi Adebiyi, J Olufemi Ogunbiyi, Oseremen Inokhoife Aisuodionoe-Shadrach, Lindsay Petersen, Wenlong Carl Chen, Jo Mcbride, Jeannette T Bensen, James L Mohler, Jack A Taylor, Caroline Andrews, Mbaaga Kigongo, Amanya Colline, Vicky Kiddu, Juliet Namugambe, Shallot Owamaani, Kuteesa Job, Benon Joseph Masaba, Frank Asiimwe, Proscovia Muwanga, Joy Namulondo, Florence Nagawa, Charity Kayiraba, Martin Ogwang, Ronald Okidi, David Oweka, Elio Kitara, James Obonyo, Daniel Lajul, Paul Matovu, Precious Arinda Muheki, Johnson Natumanya, Emmanuel Agaba, Emmanuel Aculokin, Amos Twongyeirwe, George Mutema, Denis Bitamazire, Eboneé N Butler, Sue Ann Ingles, Benjamin A Rybicki, Janet L Stanford, Wei Zheng, Sonja I Berndt, Stephen J Chanock, Chad D Huff, Joseph Lachance, Luc Multigner, Burcu F Darst, Timothy R Rebbeck, Laurent Brureau, Stephen Watya, David V Conti, Christopher A Haiman
Faculty, Staff and Student Publications
BACKGROUND AND OBJECTIVE: The impact of germline pathogenic variants (PVs) in cancer predisposition genes on risk of prostate cancer (PCa) remains understudied in large populations of African ancestry. This study aims to characterize the range of genetic risk of PCa and aggressive disease phenotypes in men of African ancestry.
METHODS: We analyzed 7176 PCa cases and 4873 controls from seven countries across North America and Africa to assess the association between PVs in 37 cancer predisposition genes and the risk of overall, aggressive, and metastatic PCa. Genes significantly associated with PCa risk were used to estimate lifetime absolute risk based …
Mutant P53 Variants Differentially Impact Replication Initiation And Activate Cgas-Sting To Affect Immune Checkpoint Inhibition, Kang Liu, Lidija A Wilhelms Garan, Fang-Tsyr Lin, Weei-Chin Lin
Mutant P53 Variants Differentially Impact Replication Initiation And Activate Cgas-Sting To Affect Immune Checkpoint Inhibition, Kang Liu, Lidija A Wilhelms Garan, Fang-Tsyr Lin, Weei-Chin Lin
Faculty, Staff and Students Publications
Prior research shows that Akt-dependent phosphorylation of TopBP1 in S phase results in the switch of TopBP1/Treslin binding to TopBP1/E2F1 binding, which is important to prevent replication re-initiation in late S and G2 phases. Here, we demonstrate that contact, but not conformational, mutant p53 can override this switch by binding to both TopBP1 and Treslin, thereby facilitating persistent TopBP1/Treslin interaction in late S and G2 phases, which ultimately leads to over-firing of replication initiation. This increases micronuclei formation, which is further enhanced by genotoxic stressors such as doxorubicin, PARP inhibitors, or ATR inhibitors. Consequently, contact mutant p53 increases the sensitivity …
The Historical Shift On Depression: Psychoanalysis To Neuroscience, Melina Kehtar-Navaz
The Historical Shift On Depression: Psychoanalysis To Neuroscience, Melina Kehtar-Navaz
The Bear Counseling Collective
Depression, a condition that affects millions of people worldwide, has been an important subject for the collaboration between psychologists, medical doctors, and beyond. Over the past century, our understanding of depression has undergone a transformation from theory-driven insights of psychoanalysis to the biological and brain-based medical and cognitive models that currently dominate research in the field. In the early 20th century, psychoanalysts like Sigmund Freud proposed an original definition and cause for depression, including components of unconscious conflicts. Today, with advancements in neuroscience and biological psychiatry, depression is a disorder of the brain that is affected by multiple components of …
A Detestable Nation Of Orcs: Echoes Of Eurasian Nomads In Early Fantasy And The Literary Ecosystem Behind Them, Axel Hansen
A Detestable Nation Of Orcs: Echoes Of Eurasian Nomads In Early Fantasy And The Literary Ecosystem Behind Them, Axel Hansen
Journal of Tolkien Research
It is well known that Orcs and Easterlings in J.R.R. Tolkien's works share features with Eurasian nomadic peoples such as Huns and Mongols. The same is true for Tolkien's literary predecessor William Morris' Dusky Men in The Roots of the Mountains. This article will provide an examination of these features from a historical viewpoint, on how interactions with and subsequent records about various steppe nomads in European history can be tied to villains in early modern Fantasy literature. It will then present a short review of how a network of historic accounts, academic theories and pop cultural works – …
Evaluating Soil Responses To Three Different Tillage Practices, Robert L. Burchett, Cordale L. Straub Senior, Logan D. Renfrow Sophomore
Evaluating Soil Responses To Three Different Tillage Practices, Robert L. Burchett, Cordale L. Straub Senior, Logan D. Renfrow Sophomore
Scholars Week
Evaluating Soil Responses to Three Different Tillage Practices
Luke Burchett, Logan Renfrow, and Cordale Straub
Mentor: Dr. Iin Handayani Ph.D
Hutson School of Agriculture, Murray State University, Kentucky, USA
ABSTRACT
Tillage systems can greatly affect soil health by changing its structure, chemistry, and biological activity. This study examined how soil organic carbon (SOC), soil pH, soil moisture, soil organic matter (SOM) responds under three tillage systems: no-till, biannual tillage, and conventional tillage. Soil samples were taken from a 1–7.6 cm depth during September 2025 across three locations. The no-till site was located in Caldwell County, Kentucky, on an irrigated double-crop …
Impact Of Crop Rotation And Species Variation On Soil Quality Indicators, Somasekhar Auduti, Uday Kiran Pittala, Pratibha Adhikari
Impact Of Crop Rotation And Species Variation On Soil Quality Indicators, Somasekhar Auduti, Uday Kiran Pittala, Pratibha Adhikari
Scholars Week
Impact of Crop Rotation and Species Variation on Soil Quality Indicators
Pratibha Adhikari, Somasekhar Auduti, Uday Kiran Pittala
Mentor: Dr. Iin P. Handayani, Ph.D.
Hutson School of Agriculture, Murray State University, Murray, KY, USA
Designing crop rotations that counter the negative effects of monocropping requires crop choices that build carbon and create stable pore structure. The objective of this research was to evaluate the effects of crop rotation on selected soil health indicators and to interpret soil health conditions across agricultural fields. Soil samples were collected from West Farm, Murray, KY, from six crop fields—corn, soybean, tobacco, millet, cotton, and …
Assessing Soil Quality Indicators In Leguminous And Non-Leguminous Cropping Systems, Kabita Budthapa, Kranthi Vinukonda, Ramya Sree Teeguri
Assessing Soil Quality Indicators In Leguminous And Non-Leguminous Cropping Systems, Kabita Budthapa, Kranthi Vinukonda, Ramya Sree Teeguri
Scholars Week
It is crucial to understand how different cropping systems influence soil health to boost the efficiency of resources and sustainable agricultural outputs. This study examined the effects of leguminous (soybean and pea) and non-leguminous (sunflower and maize) cropping systems on selected soil characteristics. On September 16th, 2025, soil samples (24 disturbed and 24 undisturbed) were collected from the 0-7.5 cm depth of West Farm, Murray, Kentucky. Disturbed samples were analyzed for pH, soil organic matter (SOM), and soil organic carbon (SOC), while undisturbed samples were used to determine bulk density, porosity, soil water holding capacity (SWHC), and soil water field …