Digital Commons Network^™

Fiber Photometry Analysis Of Spontaneous Dopamine Signals: The Z-Scored Data Are Not The Data, Conner W. Wallace, Clare Y. Slinkard, Rachael Shaughnessy, Katherine M. Holleran, Samuel W. Centanni, Christopher C. Lapish, Sara R. Jones

Department of Medicine Faculty Publications

Fluorescent sensors have revolutionized the measurement of molecules in the brain, and the dLight dopamine sensor has been used extensively to examine reward- and cue-evoked dopamine release, but only recently has the field turned its attention to spontaneous release events. Analysis of spontaneous events typically requires evaluation of hundreds of events over minutes to hours, and the most common method of analysis, z-scoring, was not designed for this purpose. Here, we compare the accuracy and reliability of three different analysis methods to identify pharmacologically induced changes in dopamine release and uptake in freely moving C57BL/6J mice. The D1-like receptor antagonist …

Visual Thinking Informed By Repetition: A Practice-Based Methodology, Julia Heurling

School of Art, Design and Architecture Theses

This artistic research proceeds from the idea that visual thinking is thinking about images through images. It explores how ideas are instigated, developed, and articulated exclusively through visual elements from a practice-based perspective. The use of repetition as a method of thinking is rooted in my previous practice as a pattern designer. I consider this a cognitive process based on the assumption that repetition is a tool for abstraction, as it changes one’s perspective from the particular to the general. Abstraction, in this context, becomes a method for processing information (i.e. to think visually).My artistic practice is engaged in combining …

Ontological Machines: Subjectivity And Relational Desire In Immersive And Interactive Environments, Toby Chanter

School of Art, Design and Architecture Theses

This practice-based artistic research focuses on two contemporary spaces; namely the pedagogical spaces of healthcare Simulation Based Education (SBE), and the exhibition spaces of installation art. These seemingly unrelated activities share a range of technological and operational similarities that render their combined study under the banner of ‘immersive and interactive environments’ both novel and necessary. The lack of broad engagement with questions of representation, aesthetics, and affect is conspicuous in an educational practice that is reliant on, and implemented through, a network of overtly visual mediums, material technologies, and sensory modalities. In healthcare SBE, clinical skills are acquired, and medical …

Above And Below The Horizon: A Practice-Led Investigation Into Liminal Thresholds Of Bodies Of Water, Rachael Allain

School of Art, Design and Architecture Theses

This thesis contributes to the debate on the interactions between art, science, and phenomenological experience, whilst offering new possibilities for investigation in this interdisciplinary field. The research investigated thresholds of the aquatic horizon; the outline in the distance where sky and water appear to coalesce. Artistic practice and critical discourse challenged and interrogated the intersection between analogue and digital, still and moving technologies, revealing aspects of the physical and conceptual horizons within and beyond the visible light spectrum. A range of theoretical concepts reconfigured my readings and interpretations of the phases of experience, through liminality and phenomenology. This provided a …

Un-Framing Transiting Trajectories: A ‘Beyond Disciplinary’ Approach To Curating In The Context Of Art And Science Discourse, Christina Ioanna Kazakou

School of Art, Design and Architecture Theses

Abstract

Artist Designed Systems In Community Radio, Lucinda Guy

School of Art, Design and Architecture Theses

Skylark is a full-time licensed radio station, founded by the author of this thesis. Since 2020 it has broadcast a continuous and ever-changing sound installation, rejecting the conventional radio schedules of presenters, programmes, music tracks, adverts etc. Its content is drawn from contributors within Dartmoor National Park, and includes oral histories, music, poems, field recordings, archive material and fragments of bespoke music. Skylark is also a public service and research project that intends to offer an innovative way forward for community radio in the UK. Such stations are intended to respond to their locations, include multiple voices, and be not-for-profit. …

#Tribe: A Study On Digital Tribalism In Saudi Arabia, Maha Alrehaili

Electronic Theses and Dissertations

This dissertation examines digital tribalism in Saudi Arabia as a lens through which to explore the complex interplay between state, identity politics, and social media in an era of rapid transformation. Amidst ambitious modernization efforts under Vision 2030 and ongoing economic restructuring, the Saudi state has sought to establish a national identity by leveraging tribal heritage. This study investigates how the three major tribes, Harb, Qahtan, and Otaibah, are responding to rapid modernization through an examination of their digital presence on X (formerly Twitter).

Employing a comparative case study design and content analysis of three years of digital activity, this …

Investigation Of Multiple Factors Influencing The Vector-Borne Transmission Of Salmonella Typhimurium Via Blattella Germanica, Landen Sean Van Hulzen

Dissertations and Theses

The German cockroach (Blattella germanica) is a common urban pest that lives ubiquitously in human structures around the world. German cockroaches are a severe public health threat as they are known carriers and vectors of human pathogens including Salmonella enterica, Escherichia coli, Shigella spp, and more. German cockroach infestations have been associated with Salmonellosis outbreaks. While mechanical transmission by the German cockroach vector is well known, new research suggests that more nuanced biological transmission has a role in maintaining and transmitting Salmonella enterica serovar Typhimurium (S. Typhimurium). Despite this recent finding, many biological variables influencing vector-borne transmission of S. Typhimurium …

Convergence In Cancer: Integrative Multi-Modal Modeling For Pan-Cancer Drug Response Prediction, Jessica Zylla

Dissertations and Theses

Heterogeneity and rarity can make cancer difficult to study and treat. Cancer's heterogeneity, evident in tumor locations, tumor cell types, subtypes, and microbiota within the tumor microenvironment, complicates diagnosis, prognosis, and treatment. Research into the tumor microenvironment and its microbiota is an evolving area of oncology that may advance cancer drug-patient response. Cancer-omics signatures are crucial to drug response, yet there is no tool that physicians use as a gold standard. Research indicates that microbial presence can alter drug metabolism and immune response, affecting cancer-drug efficacy on a patient-specific basis. This work highlights the need for training readiness in transdisciplinary …

American Indian Survivors Of Domestic Violence And Self-Perceived Mental Health After Seeking Domestic Violence Services, Arial Swallow

Dissertations and Theses

Domestic violence has long-term impacts on women’s emotional, psychological, and physical health, with American Indian women experiencing disproportionately high rates of violence and face unique barriers in overcoming challenges of healing. As part of a larger study, this research aimed to better understand the healing process of American Indian women domestic violence survivors in rural areas. This study examined findings from a mixed methods approach, which investigated the significance of identifying co-occurring mental health needs and providing support, education, and resources to address these needs. The research utilized a quantitative method of descriptive statistics, identifying survivors who endorsed mental health …

Your Foot Is Not A Brick: Using A Multi-Segment Foot Model To Explore The Actions Of The Ankle-Foot Complex During Uneven Terrain Gait., Tayler Jon Hoekstra

Dissertations and Theses

The field of biomechanics has seen continued development of models to be used and circumstances to be considered. An increasing number of more complex models for the foot known as multi-segment foot models (MSFMs) have created opportunities to better understand the compensatory motion of this vital portion of human anatomy. This research seeks to utilize one such MSFM model to increase understanding in how human ambulation changes in uneven terrain environments. Unique inner-foot joints defined by the Rizzoli foot model (RFM) were measured for and compared for subjects traversing both even and uneven terrain to quantify joints that experienced significant …

An Exploration Of The Experiences And Factors Influencing Physical Activity In People With Parkinsons, Heather Hunter

School of Health Professions Theses

Abstract:Background: Physical activity plays a crucial role in enhancing the well-being and quality of life of people with Parkinsons. Despite substantial evidence supporting its benefits, people with Parkinson’s struggle to maintain an active lifestyle. This thesis explored the perspective of people with Parkinsons on their engagement in physical activity.Methodology: This research employed a person-centred approach, comprised of three sequential phases. Phase One: A systematic review utilising the JBI approach of meta-aggregation synthesised the best available qualitative evidence of people with Parkinson's' views and preferences regarding physical activity interventions. Phase Two: Constructive Grounded Theory was used to explore the beliefs, attitudes, …

The Role Of A Pelvic Orthotic In The Management Of Chronic Pregnancy-Related Pelvic Girdle Pain: A Feasibility Study And Validation Of A Novel Body Perception Measure, Bradley Halliday

School of Health Professions Theses

Chronic pregnancy-related pelvic girdle pain (PPGP) affects an estimated 10% of post-partum women and is typically recalcitrant to conservative management. One novel option to manage this is a customised Dynamic Elastomeric Fabric Orthosis (DEFO), however, currently non studies have evaluated the clinical and cost-effectiveness or acceptability of this orthotic in post-partum women. Further, the mechanism of action of this orthotic is unknown. One mechanism may be to impart an effect on the disturbed body perception, which preliminary evidence has demonstrated is affected in women with PPGP. Current understanding is limited by an absence of research into women with PPGP and …

The Role Of Oral Nitrate Reducing Bacteria In Cardiovascular Health: Impacts Of Diet And Exercise, Craig Clarke

School of Health Professions Theses

This thesis investigated the important role of oral bacteria in blood pressure regulation and vascular function through the NO3--NO2--NO pathway following exercise or dietary interventions. Study 1 examined the effect of antibacterial mouthwash on the oral microbiome and nitrate metabolism in vegetarians and omnivores. Notable alterations in bacterial composition were observed after mouthwash administration, including reductions in the Prevotella genus (from 27.7% to 9.6%, P = 0.001) and Actinomyces genus (from 9.5% to 5.7%, P = 0.001), along with decreases in Prevotella melaninogenica (from 18.1% to 6.2%, P = 0.001) and Rothia dentocariosa (from 0.09% to 0.04%, P = 0.001). …

The Revolving Door Of Epilepsy Emergencies, Sarah Lennard

School of Health Professions Theses

This thesis explores the revolving doors of epilepsy emergencies, focusing on the key factors that contribute to repeated attendances at emergency departments (ED) following seizures. The study is based on five peer-reviewed journal articles that provide a comprehensive review of current evidence, risk factors for ED attendance, clinicians' perspectives, and the use of technology in epilepsy management. The research identifies several critical factors influencing ED attendances, including mental health issues, medication adherence, and social determinants such as deprivation and homelessness. The findings highlight the need for integrated care pathways, improved communication between healthcare providers, and targeted interventions for vulnerable populations. …

A Critical Exploration Of Social Transformation Through Occupation, Miranda Cunningham

School of Health Professions Theses

Background: In occupational therapy and occupational science, scholars and practitioners advocate for a stronger focus on social transformation. However, there is limited evidence on how occupation-based interventions contribute to addressing inequalities and fostering change for marginalised populations. Methods: This study applied critical occupational science and realist theoretical frameworks to examine the use of arts-based occupations for social transformation. It comprised three strands: (1) a narrative review of arts-based occupations in social change, (2) a realist review of participatory photography, and (3) a realist evaluation of a socially engaged art group in primary schools. Findings: Arts-based occupations have been employed by …

Investigating The Link Between The Oral Microbiome And Cardiovascular Health In Regards To Nitrate/Nitrite Metabolism., Lisa Du Toit

School of Health Professions Theses

This thesis evaluated nitrate metabolism and the link between cardiovascular health and periodontal disease. The first study compared effects of high-nitrate vegetables and pharmacological salt supplementation on the oral microbiome composition in hypertensive individuals. Seventy participants (50-70-y-old, clinical systolic BP (SBP) 130-159 mmHg, diastolic BP (DBP) <110 mmHg) were randomly allocated to group 1 (n = 24) consuming 300 mg/d nitrate in green leafy vegetables form, group 2 (n = 23) consuming 300 mg/d potassium nitrate in form of pills and low-nitrate vegetables, and group 3 (n = 23) consuming potassium chloride pills (placebo) and low-nitrate vegetables. Groups 1 and 2 showed similar microbial salivary changes, increased Neisseria species, and decreased Veillonella species post treatment, suggesting nitrate-dependent changes.The second study investigated oral health and microbiome composition of pregnant women with pre-eclampsia (n = 10, SBP = 150 ± 8 mmHg, DBP = 98 ± 9 mmHg) compared to normotensive pregnancies (n = 11, SBP = 111 ± 5 mmHg, DBP = 80 ± 9 mmHg). Pregnant women with pre-eclampsia showed higher plaque levels compared to normotensive pregnant women (P = 0.038), although activity of oral nitrate-reducing bacteria (P = 0.088) was not statistically significant. Plasma nitrate levels were significantly were lower in women with pre-eclampsia (P = 0.024). The third study evaluated the effect of chlorhexidine (CHX-M n= 21) and propolis (PROP-M n= 24) mouthwashes on abundance and activity of nitrate-reducing bacteria in healthy individuals. CHX-M increased relative abundance of nitrate-reducing bacteria (P < 0.001), but significantly impaired nitrate-reducing activity (P < 0.001) compared to baseline and PROP-M. PROP-M significantly increased plasma nitrate levels (P = 0.047) and reduced systolic BP (P = 0.022).The fourth study compared the effect of CHX-M, PROP-M, amoxicillin (AMX) and metronidazole (MTZ) on salivary nitrate-reducing activity within a 24-hour period using an in-vitro protocol. Results showed that MTZ significantly increased nitrate-reducing activity after 24-hours (P = 0.001) compared to all the other treatments (AMX, P = 0.025; CHX-M, P = 0.01; PROP-M, P = 0.023). Overall, this thesis suggests that poor oral health may impair the oral nitrate–nitrite pathway, thereby reducing nitrate bioavailability in women with pre-eclampsia. Diets rich in high-nitrate vegetables showed beneficial changes in the oral microbiome; however, these were not associated with blood pressure reduction. In contrast, use of propolis mouthwash increased plasma nitrate bioavailability, contributing to blood pressure reductions. Finally, it was observed metronidazole significantly enhanced nitrate-reducing activity.

Factors Affecting Metabolism And Metabolic Control In Phenylketonuria, Alex Amorim Pinto

School of Health Professions Theses

Phenylketonuria (PKU) is an inherited metabolic disorder treated by a phenylalanine restricted diet in order to avoid neurocognitive impairment. Blood phenylalanine is the main outcome marker which is modulated by many dietary factors. Traditionally, L-amino acid-based protein substitutes are the main nitrogen source but more recently glycomacropeptide-based protein substitutes (GMP) have been introduced and are associated with several health benefits. The following aspects were studied in this thesis: 1) metabolic control achieved in patients with PKU compared with the European PKU guidelines; 2) life-long change in natural protein tolerance; 3) impact on metabolic control of different natural protein sources (animal …

Reproductive Innovation And Reproductive Exceptionalism: How Private Health Insurance Coverage Of Fertility Treatment Complements Hostile Governmental Action And Expands Access To Assisted Reproduction In The United States, Myrisha S. Lewis

Faculty Publications

The use of fertility treatment and assisted reproductive technology (ART) in the United States and globally is increasing over time. As of April 2023, the World Health Organization estimates that approximately one in six individuals have faced infertility globally. Fertility treatment includes the use of drugs to stimulate egg production, in vitro fertilization (IVF), and, for some, the use of gestational surrogacy to aid in childbirth. Debates have abounded and continue to abound in federal legislatures, state legislatures, and society more broadly about the morality of abortion, contraception, and assisted reproduction, as well as whether governments, public insurers, and private …

Bringing Self-Determination Theory To The Forefront: Examining How Human Resource Practices Motivate Employees Of All Ages To Succeed, Rick A. Laguerre, Janet L. Barnes-Farrell

Management Faculty Research and Publications

Self-determination theory (SDT) is widely used in human resource (HR) practice studies to explain how HR practices impact work outcomes. However, there is little empirical evidence establishing the complete SDT mediational process in the HR domain, which entails basic psychological needs and motivation acting as mediators of relations between HR practices and work outcomes. The present study addresses this issue with a mixed methods approach. Using an item classification task with subject matter experts (N = 48), HR practices were classified as autonomy-, competence-, and relatedness-supportive. Based on this scheme, we tested an SDT-based conceptual model in a three-wave …

Graduate Catalog 2025-2026, Southwestern Oklahoma State University

Graduate Catalogs

No abstract provided.

Protocol For Development And Validation Of An Early Intervention Device And Its Influence Using Structured Early Physiotherapy (Preemiestep) Intervention On Neuromotor Development In Preterm Infants, Indira D. B. Naidu Boddapati, Sivakumar Gopalakrishnan, Sonia Khurana, Jayashree Purkayastha, Bhaskar Bhatt, Bhamini Krishna Rao

Rehabilitation Sciences Faculty Publications

Early physiotherapy interventions for Moderate to Late Preterm (MLP) infants often lack continuity of care from hospital to home settings. This research aims to develop an Early Intervention (EI) device for home program and determine its influence using STructured Early Physiotherapy (Preemie STEP) intervention in MLP infants. For phase I, qualitative interviews will be conducted with healthcare professionals and parents, to understand user needs on developed prototype. Based on identified needs, an EI device will be developed using a human-centered design approach and iterative design process. In phase II, usability and validity of EI device will be …

Havana Syndrome: A Scientific Review Of An Unresolved Medical Mystery, Aishik Dutta

Digital Journal of Clinical Medicine

Background

Since 2016, U.S. and Canadian officials have reported Anomalous Health Incidents (AHIs), or "Havana Syndrome," characterised by a strange sensory experience followed by chronic neurological, cognitive, and vestibular issues. The cause is intensely debated, with primary hypotheses pointing to either psychosocial factors or a directed-energy weapon, creating a significant medical and geopolitical puzzle.

Methods

This review critically assesses the current evidence by analysing peer-reviewed clinical studies and major institutional reports.

Results

The findings are deeply contradictory. A 2020 NASEM report identified directed, pulsed radiofrequency energy as the most plausible mechanism for a core set of symptoms. Conversely, comprehensive 2024 …

Sustainable Hospitals Lighting Design Optimization To Enhance Patient Well-Being, Merna R. Ashac, Rania F. Ismail, Nasreen Fathy Abdelsalam

Mansoura Engineering Journal

This research investigates the critical role of lighting design in hospitals environments, focusing on its impact on patient outcomes and environmental sustainability. By integrating energy-efficient LEDs and natural light, the study aims to enhance patient well-being and staff performance. To achieve this, the research explores aligning artificial lighting with circadian rhythms to improve both patient outcomes and staff performance. Using mixed-methods approach, the research includes a literature review, case studies, and analysis using DIALux simulation software. The literature review achieves a framework for sustainable, human-centric lighting, while case studies provide practical insights into effective designs in patient rooms. DIALux simulations …

A Multi-Variate Rotating Machinery Fault Optimization And Recognition Framework, Ahmed M. Abdelrahman, Amira Y. Haikal, Mahmoud M. Saafan

Mansoura Engineering Journal

Accurate diagnosis, prognosis, and forecasting of a machine's time-to-failure are crucial through the massive, profound monitoring parameters and expeditiously is essential to assist in the preservation of reliability and life remaining for the machine increase by recommending an appropriate decision to diminish the occurrence of ruinous malfunction and substantial financial losses proactively. Artificial intelligence is considered significantly crucial to specialists in diagnosing various faults. But all research, although have great accuracy, still till now have a lack on the number of considering parameters to achieve the diagnosis or prognosis.in addition to, it depends on repeat the processing for sensor reading …

Optimal Design Of An Off-Grid Hybrid Renewable Systems With Battery Storage For Rural Electrification Of Academic Community In Ibogun Campus, Nigeria, Ayodeji Akinsoji Okubanjo, Alexander Okandeji, Ignatius Kema Okakwu, Benjamin Akinloye, Abisola Olayiwola

Mansoura Engineering Journal

In an era where the debate on climate action has evolved from mere awareness to urgent implementation, energy-efficient management strategies are crucial. The energy mix, combined with optimal design of hybrid renewable energy systems, is a potential option to limit the increase in demand for fossil fuels and the climate issue. As a result, this study proposes an optimal design of hybrid renewable systems using technoeconomic criteria to meet load demand in the Department of Electrical and Electronics Engineering at Olabisi Onabanjo University. The model combines an off-grid energy alternative with a battery storage system. The primary goal is to …

Effects Of Crevice Corrosion On Metal Adhesive Performance And Shear Strength In Marine Environments, Westin Johnson

Electronic Theses and Dissertations

Corrosion is a leading challenge that engineers and researchers face when working in marine environments. Annually, corrosion costs an estimated $2.5 trillion globally and can lead to environmental damage and pose a threat to public safety. This thesis investigates the effects of crevice corrosion on the performance of different epoxy adhesives when mated with stainless steel to determine if using epoxy is a viable option for the development of systems operating in marine environments. To accomplish this, metal-to-metal lap shear samples were created using Araldite 2015-1, Plexus MA560-1, Plexus MA310, and Plexus MA8120 epoxies and different preparation methods. These samples …

Evaluation Of The Corrosion Of Metallic Fastener Joints In Composite Materials Immersed In Seawater, Chloe Derrico

Electronic Theses and Dissertations

The corrosion behavior of metallic fasteners in contact with composite materials in marine environments remains a critical concern for structural integrity and long-term performance. This study evaluates the corrosion of marine fasteners of various materials in contact with glass fiber, carbon fiber, hybrid glass-carbon fiber, and G10/FR-4 Garolite composite plates. The research focuses on localized corrosion mechanisms, include crevice and pitting corrosion, as well as the influence of composite interactions. Samples were exposed to three environmental conditions: full immersion tanks, tidal tanks simulating the high and low tides, and deployment on a barge on Florida’s intracoastal waterway, with antifouling paint …

Dialectical Behavior Therapy Integration In Counselor Education: Theory, Development, Implementation, And Efficacy Of A Dbt-Informed Supervision Protocol For Counselor Trainees, Clara Bossie

Electronic Theses and Dissertations

This multi-manuscript dissertation illustrates the progression from theoretical development to practical intervention research in counselor supervision, introducing innovative supervisory practices in counselor education that balance well-being with academic rigor, addressing counselor trainees' common challenges such as anxiety, burnout, and limited self-efficacy. Following a literature review, this dissertation bridges theory and practice by offering counselor educators and supervisors a comprehensive, evidence-informed approach to developing resilient, competent, and psychologically well counseling professionals. The research progresses through three interconnected phases using qualitative and quantitative methods. Constructivist grounded theory (CGT) explores counselor trainees' supervisory experiences, highlighting the significance of responsive supervisory relationships and validation. …

Does Exclusive Breastfeeding Duration And Quality Affect Maternal Sensitivity: Fear Vs. Normative Situations, Camila Herrera Zamora

Electronic Theses and Dissertations

The present study examined whether exclusive breastfeeding duration and perceived breastfeeding quality predict maternal sensitivity across emotionally challenging versus normative caregiving contexts in infancy. Twenty-four mother–infant dyads participated in three laboratory visits during which maternal sensitivity was assessed across interaction conditions. It was hypothesized that (1) longer breastfeeding duration would be associated with greater sensitivity during fear-inducing contexts, (2) breastfeeding duration and quality would interact to predict sensitivity, and (3) sensitivity would be higher during fear-inducing situations. Contrary to expectations, maternal sensitivity was highest in the normative/free-play condition and increased over time, peaking at 14 to 16 months. Exclusive breastfeeding …