Digital Commons Network^™

Wet Aging For 21 Days Improves Tenderness Of Beef Biceps Femoris Muscle Without Affecting Color Stability, Ana Paula A.A. Salim, Mahesh N. Nair, Yifei Wang, Anna C.V.C.S. Canto, Gregg Rentfrow, Surendranath P. Suman

Animal and Food Sciences Faculty Publications

Beef whole-muscle cuts containing biceps femoris (BF) exhibit inferior tenderness compared to cuts from the ribs and loins. The BF is a sizeable muscle in beef round, and enhancing tenderness of BF may increase the value of beef carcasses. While wet aging for 21 d improves beef tenderness, it can compromise color. Therefore, we evaluated the effects of wet aging on color and tenderness of beef BF to identify an optimal aging duration for these quality traits. The BF muscles were collected 24 h postmortem from 8 beef carcasses (n = 8), divided into equal sections, vacuum packaged, and aged …

Automated Sponge Segmentation With Mask R-Cnn On Arms Plate Images For Reef Monitoring, Mrunali Abhijit Thokadiwala

Master's Projects

Climate change-driven ocean warming and acidification are disrupting the ecological balance of coral reefs. Notably, these oceanic conditions are undermining coral health and accelerating their decline which is favoring some sponge species in outcompeting them for dominance. Although functional, these altered reefs destabilize the reef architecture, hinder nutrient cycling, and support fewer marine species. Thus, monitoring the growth and abundance of various sponges and understanding their roles at different stages of ecological succession in coral reefs is vital. Autonomous reef monitoring structures (ARMS) are often used for this purpose, but manual taxonomic analysis using their images is time-consuming, inconsistent and …

Evorgcn: Harnessing Esm-2 Evolutionary Embeddings With Relational Gcns For High-Fidelity Protein-Protein Interaction Prediction, Mohit Kunder

Master's Projects

Accurately predicting protein-protein interactions (PPIs) is essential for understanding cellular function and advancing biomedical discovery. We model PPIs as graphs, where nodes represent proteins and edges denote interactions. Using interaction data from the STRING database, we use two samples of it, namely the benchmark datasets—SH27K and SH148K—filtered by confidence score and annotated by interaction mode (multiple relations). In this project, we present EvoRGCN, a graph-based machine learning framework for PPI prediction that integrates both sequence-level (ESM-2 embeddings) and network-level information. We incorporate various Graph Neural Network architectures, including Graph Convolutional Networks, Graph Attention Networks, and Relational Graph Convolutional Networks. Our …

Variations Of Hex Bar Deadlifts On Post-Activation Performance Enhancement In Collegiate Baseball Athletes, Samuel Sanders

College of Graduate Studies: Theses & Dissertations

Single-session resistance priming protocols are used by strength and conditioning coaches to acutely improve neuromuscular mechanisms that are beneficial to athletic performance. This study aimed to examine if a concentric-only hex bar deadlift (CHBDL) would produce a similar post-activation performance enhancement (PAPE) effect as a full-range-of-motion hex bar deadlift (THBDL) and mitigate perceived measures of fatigue and soreness in collegiate athletes. 19 NCAA Division I baseball athletes completed the study. A repeated measures design with randomized assignment and counterbalanced order was utilized. Over two weeks, the CHBDL and THBDL were added into a typical priming protocol used by the team’s …

Digital Modeling Of Temperature-Dependent Processes In Industrial Wastewater: Advancing Ultimate Oxygen Demand Prediction For Treatment Optimization, Fatima Iqbal

College of Graduate Studies: Theses & Dissertations

The pulp and paper industry is the third-largest consumer of freshwater globally and faces mounting pressure to optimize water usage and minimize environmental impact. Aerated stabilization basins are extensively utilized in the pulp and paper industry and play a crucial role in treating wastewater from these operations. The existing management practices fail to effectively optimize treatment processes due to the prolonged time required for testing key quality parameters. The utilization of models developed for treatment facilities presents a viable solution; however, existing open-source models often fall short in accurately predicting treatment efficiency across varying conditions and lack comprehensive accounting of …

Investigating The Role And Expression Of Aquaporin 10 Paralogs In Spiny Dogfish (Squalus Acanthias), Esosa Omoregie

College of Graduate Studies: Theses & Dissertations

Aquaporins (AQPs) are integral membrane proteins that facilitate the selective transport of water and small solutes across cell membranes, playing essential roles in maintaining osmotic balance in vertebrates. Among them, aquaglyceroporins such as AQP10 are capable of transporting water, glycerol, and urea, contributing to osmoregulatory and metabolic processes. This study investigated the expression, localization, and potential physiological roles of two AQP10 paralogs, AQP10C1 and AQP10C2, in the spiny dogfish (Squalus acanthias), a marine elasmobranch that maintains osmotic equilibrium through urea retention and ion regulation. Using RT-PCR, quantitative PCR, Western blotting and immunohistochemistry the study identified tissue-specific expression patterns of …

Assessing The Impact Of Environmental Health Risk Communication On Cancer Screening Intentions Among Private Well Owners In Rural Communities, Victoria A. Clower

College of Graduate Studies: Theses & Dissertations

Background: Cancer is a leading cause of death in Georgia, with rising incidence in rural counties where many residents rely on unregulated private wells. These wells may contain contaminants such as radon, lead, nitrate, and arsenic, all linked to increased cancer risk. Limited research has explored how environmental exposure awareness influences cancer prevention behaviors such as screening. Guided by the Champion Health Belief Model, this study examined psychosocial and environmental predictors of screening intent among private well owners. Methods: Well Aware was an 11-week quasi-experimental study among 60 private well owners in southeast Georgia. Participants who attended educational listening sessions …

Determination Of Structural Factors Contributing To Protection Of Zinc Fingers In Estrogen Receptor Α Through Molecular Dynamic Simulations, Patricia B. Lutz, Wesley R. Coombs, Craig A. Bayse

Chemistry & Biochemistry Faculty Publications

The ERα transcription factor that induces tumor growth is a potential target for breast cancer treatment. Each monomer of the ERα DNA-binding domain (ERαDBD) homodimer has two conserved (Cys)₄-type zinc fingers, ZF1 (N-terminal) and ZF2 (C-terminal). Electrophilic agents release Zn²⁺ by oxidizing the coordinating Cys of the more labile ZF2 to inhibit dimerization and DNA binding. Microsecond-length molecular dynamics (MD) simulations show that greater flexibility of ZF2 in the ERαDBD monomer leaves its Cys more solvent accessible and less shielded from electrophilic attack by sulfur-centered hydrogen bonds than ZF1 which is buried in the protein. In the …

Phytochemical Analysis, Antioxidant, And Antibacterial Properties Of Partition Fractions Of Adansonia Digitata And Annona Muricata Extracts Using Chloroform, Ethyl Acetate, Ethanol, And Aqueous Solvent Systems, Fagbohun Oyenike Bushirat, Hassan Abdusalam Adewuyi, Sakariyau Adio Waheed, Maryam Nana Musa, Timothy God-Giveth Olusegun, Ayomide Babatunde Ishola, Agumage Idoko, Adeola Victor Kolawole, Adesanmi Adefunmilayo Oluwatuyi, Sarah Ngozi Agwasim

Chemistry & Biochemistry Faculty Publications

Adansonia digitata and Annona muricata are traditionally used medicinal plants with reported pharmacological properties. In this study, we aimed to elucidate the phytochemical composition, antioxidant activity, and antibacterial properties of partition fractions of Adansonia digitata and Annona muricata extracts obtained using chloroform, ethyl acetate, ethanol, and aqueous solvent systems. The plant extracts were successively partitioned using chloroform, ethyl acetate, ethanol, and aqueous solvent systems. Phytochemical analysis was performed using standard methods. Antioxidant activity was evaluated using FRAP and DPPH assays. Antibacterial activity was assessed using agar well diffusion and MIC determination. Phytochemical analysis revealed the presence of alkaloids (10.2-15.6%), flavonoids …

The Importance Of Solution Studies For The Structural Characterization Of The Enterovirus 5' Cloverleaf, Morgan G. Daniels, Meagan E. Werner, Xiaobing Zuo, Steven M. Pascal

Chemistry & Biochemistry Faculty Publications

Enteroviruses initiate genomic replication via a highly conserved mechanism that is controlled by an RNA platform, also known as the 5' cloverleaf (5'CL). Here, we present a biophysical analysis of the 5'CL conformation of three enterovirus serotypes under various ionic conditions, utilizing CD spectroscopy, size-exclusion chromatography, and small-angle X-ray scattering. In general, a tendency toward a smaller monomeric hydrodynamic radius in the presence of salts was observed, but the exact structural signature of each 5'CL varied depending upon the serotype. Rhinovirus B14 (RVB14) exhibited at least two monomeric conformations and a low propensity for dimerization, while poliovirus 1 (PV1) showed …

Metal-Organic Thin Film Coated On Optical Fiber, Nahideh Salehifar

Doctoral Dissertations

This dissertation explores the development of metal-organic framework (MOF)-based optical fiber sensors for detecting volatile organic compounds (VOCs) at low concentrations (parts-per-billion to parts-per-million). In the first part of the study, theoretical calculations were performed using effective medium approximation (EMA) models, including Lorentz–Lorentz, Maxwell–Garnett, and Bruggeman equations, to predict the refractive index changes of MOFs upon gas adsorption. These models were applied to MOFs such as ZIF-7, ZIF-8, ZIF-90, MIL-101(Cr), and HKUST-1 to evaluate their potential for gas sensing.

In the second part of the dissertation, experimental work was conducted to validate the theoretical predictions. MOF-coated optical fibers were fabricated …

Design And Synthesis Of Organocatalyts For Efficient Decontamination Of Organophosphate-Based Nerve Agents And Pesticides, Emmanuel Kingsley Darkwah

Doctoral Dissertations

Exposure to organophosphate-based nerve agents and pesticides poses significant health and security threats to civilians, soldiers, and first responders. Despite extensive efforts to develop chemical detoxification agents for use in topical applications on exposed skin surfaces and for intravenous injections, there remains an unmet need for effective, non-hazardous decontaminating agents. The current state-of-the-art decontaminating agent, Dekon-139 (2,3-butanedione oxime, potassium salt), exhibits adverse effects when applied to the skin.

In this study, we designed and synthesized pharmaceutically relevant aminoguanidine-derived aldimines that are relatively non-toxic and substantially more effective at decontaminating nerve agents and pesticides compared to existing agents, and they act …

Design Of Real-Time And Energy-Efficient Driver Assist Systems Using Electroencephalogram And Neuromorphic Computing, Nathan Alan Lutes

Doctoral Dissertations

Despite the technological breakthroughs in advanced driver assist systems, distracted driving persists as a major challenge to roadway safety. This investigation advances the body of knowledge towards a solution by developing an individualized driver-state detection method using electroencephalogram (EEG) and neuromorphic computing to provide a less invasive and more energy efficient ADAS solution. It furthermore explores the changes in brain functional connectivity under distracted conditions to better understand brain state information that could be used for neuro-feedback intervention systems. The first contribution introduces the concept of using Convolutional Spiking Neural Networks (CSNNs) for recognition of patterns with movement-intention predictive power …

Novel Nano-Formulations Based On Flash Nanoprecipitation For Ocular Drug Delivery, Lin Qi

Doctoral Dissertations

Effective ocular drug delivery has always been a challenge for clinical and research. Although many nanotechnology-based formulations have been developed and showed great potential in ocular drug delivery, this is far from enough to meet clinical requirements. These studies aimed at the design and synthesis of novel nanoparticles using multi-inlet vortex mixer (MIVM) to improve ocular drug delivery efficiency. The first project involves packaging two different anti-glaucoma drugs, brimonidine (BM) and betaxolol (BX), into solid drug nanoparticles (SDNs) by MIVM, which can achieve both functions, reducing aqueous humor production and promoting aqueous humor efflux. The studies demonstrate that the SDNs …

Topics On Ai Fairness Preferences In Kidney Transplantation, Mukund Telukunta

Doctoral Dissertations

Modern kidney transplantation incorporates artificial intelligence (AI) decision-support systems which exhibit social discrimination due to biases inherited from training data. Although researchers have proposed various group-based fairness notions to assess biases in AI, it remains uncertain which criterion is most suitable for evaluating biases in such complex healthcare systems. This dissertation explores human perception of fairness to identify the most appropriate fairness criterion for assessing AI tools in kidney transplantation, focusing on the preferences of non-expert (e.g. public, patients) stakeholders. The study examines two distinct AI systems employed in kidney transplantation: a classification model and a regression model. Human subject …

Enhanced Optimization Of Mass Transfer For Carbon Capture And Wastewater Remediation In Algal Systems Through Algorithmic And Bioprocessing Techniques, Peter Ofuje Obidi

Doctoral Dissertations

The scalability and industrial deployment of algal cultivation systems are limited by suboptimal mass transfer, constraining their effectiveness in carbon capture and wastewater remediation. This research investigated these challenges through integrated optimization methodologies that combine algorithmic frameworks with enhanced bioprocessing techniques to enhance efficiency, economy, and scalability. A System-of-Systems (SoS) meta-architecture was developed using genetic algorithms and fuzzy assessor functions to demonstrate a pathway toward cost reduction. Rigorous mechanical and chemical characterizations were quantitatively analyzed to reveal existing optimization strategies and further evaluated the best strategies to use in enhancing mass transfer for improved biomass yield. The work also integrates …

Identification Of Corrosion Damage, Vibration, And Loose Conections In Aircraft Data Transmission Lines Using Reflected And Transmitted Signals; Formulation Of Vegetable Oil-Based Nanofluids As Cutting Fluids For Mql Machining, Saidanvardzhon Valiev

Doctoral Dissertations

This research presents a novel Frequency Domain Transmitometry (FDT) method that uses transmitted signals (S21) to detect and characterize aircraft data transmission lines (ADTL) corrosion damage without additional reflectometry circuitry. Corrosion experiments were conducted according to ASTM G85-A5 over 14 weeks. Combined FDT and reflected signals (S11) analyses revealed distinct three-peak signatures associated with damage and corrosion. The square root of the Area Under the Curve (AUC) of the FDT damage peak and the Full Width at Three-Quarter Maximum (FW3QM) of the S11 damage peak is correlated with corrosion propagation depth and width. S11 signals were further used for vibration …

An Investigation Into How The Prostate And Androgens Mediate Greater Levels Of Uric Acid In Males Compared To Females, Rachel D. King

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chronic elevated circulating uric acid (UA) levels (hyperuricemia) are associated with gout as well as cardiovascular, metabolic, and renal dysfunction. Men have greater mean circulating UA levels than women and are more likely to exhibit hyperuricemia. This may be partly driven by the hormonal regulation of renal UA transporters; however, a direct link between hormones and UA production has not been established. Production of UA is catalyzed by xanthine oxidoreductase (XOR / XDH), which is ubiquitously expressed but has the greatest specific activity in the liver. Interestingly, an extensive gout genome-wide association study (GWAS) recently revealed a robust genetic …

Back To The Future Self: Parsing Age Effects In Future Self-Continuity Through Goal Orientation And Life Satisfaction, Laken A. Mooney

Graduate Theses, Dissertations, and Problem Reports (ETD)

Future self-continuity, the psychological feeling of connectedness between the current and the future self, is a relatively novel concept that is associated with and has been used to predict a variety of outcomes. Though work investigating individual differences is comparatively rare, a robust demographic difference found in previous literature is the presence of an age effect, where older adults are more likely to feel a greater connection to their future self than younger adults. This finding has been replicated a number of times, but potential mechanisms behind this observed age-related increase have yet to be fully uncovered. Limited previous work …

A Comparison Of Endodontic Root-End Filling Techniques: A Micro-Computed Tomography (Micro-Ct) Analysis Part Ii, Andrew M. Marra

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

A COMPARISON OF ENDODONTIC ROOT-END FILLING TECHNIQUES: A MICRO-COMPUTED TOMOGRAPHY ANALYSIS

Andrew Marra, D.D.S.

Introduction: Researchers have compared many endodontic root-end filling techniques for porosity, though few have used a micro-computed tomography analysis for comparisons. The purpose of this study was to evaluate total porosity volume of three different bio-ceramics filling materials with two techniques--hand compaction versus hand/ultrasonic compaction at an ultrasonic setting of 5% using Micro-CT Analysis.

Methods: Seventy-two human single canaled extracted teeth were selected for the study. All were subjected to orthograde endodontic treatment followed by root tip resection at 3-mm from the apex …

Social Support And Negative Affective Outcomes Among Older Adults: Does Valuing Autonomy Matter?, Erika Anne Fenstermacher

Graduate Theses, Dissertations, and Problem Reports (ETD)

While not a normal part of aging, depression is a concerning psychiatric condition in late life. Depression is a significant predictor of suicide and the highest rates of suicide occur in middle aged and older adult men. One factor that may protect against depression and suicidal behavior among older adults is social support. Social support has been demonstrated as a significant factor in health and well-being. Perceived social support has consistently been linked to beneficial outcomes, however, received support has mixed results with some studies even finding received support to be harmful. For individuals who highly value autonomy, it may …

Exploring The Ruminal Microbiome And Its Impacts On Feed Efficiency In Beef Cattle, Taylor Simone Sidney

Graduate Theses, Dissertations, and Problem Reports (ETD)

The ability for beef cattle to utilize feed efficiently is a critical determinant for both economic and environmental sustainability in livestock production. However, despite extensive research, the complex microbial ecosystem within the rumen and its relationship to feed efficiency remain incompletely understood. This dissertation explores the physiological and microbial foundations of feed efficiency by characterizing how rumen microbial communities and their functions differ among beef cattle with divergent residual feed intake (RFI) phenotypes and how the RFI status of beef cattle influenced their response to dietary interventions such as supplementation with a Bacillus-based feed additive. In the first study, …

Teachers’ Perspectives On Behavioral Classroom Expectations Of Students With Emotional And Behavioral Disorders, Jennifer E. Brewer

Theses and Dissertations

The problem addressed in this study was that adolescents with emotional and behavior disorders (EBD) were failing in general education courses. The purpose was to investigate how teachers’ perceptions and biases influenced EBD students. Participants included five teachers (two special education teachers and three general education teachers) from each of Grades 6, 7, and 8 recruited from social media. The study was guided by the case study research design, and the interview instrument was the Indepth Interview Protocol. Data analysis was guided by a coding system that facilitated searching the interview responses for themes.

Research Question 1 queried about forms …

Engineering Extracellular Vesicles (Evs) To Combat Infection And Inflammation In Cystic Fibrosis, Sharanya Sarkar

Dartmouth College Ph.D Dissertations

Cystic Fibrosis (CF) is a multisystemic genetic disorder caused by mutations in the CFTR gene, resulting in chronic pulmonary infections, hyperinflammation, and progressive lung damage. Among the pathogens that colonize CF lungs, Pseudomonas aeruginosa (P. aeruginosa) is predominant, infecting over 50% of adults with CF and developing antibiotic resistance over time. Current modulator therapies fail to address persistent bacterial infections, chronic inflammation, or irreversible lung damage, underscoring the need for novel therapeutic strategies. In our previous in vitro studies, we demonstrated that extracellular vesicles (EVs) secreted by primary Human Bronchial Epithelial Cells (HBECs) inhibit P. aeruginosa growth by reducing the …

Delayed Tooth Eruption As An Early Clinical Indicator Of Genetical Tooth Agenesis: A Family-Based Study Of Cases With Whole-Exome Sequencing, Yu-Chen Jeng, I-Ting Chen, Hui-Ching Cheng, Hsin-Yu Huang, Chao-Kai Hsu, Yu-Fen Yen

Journal of Dental Sciences

Delayed tooth eruption is frequently considered a benign developmental variation but may represent an early sign of genetically driven tooth agenesis. We evaluated a 22-month-old female presenting with markedly delayed eruption (only eight primary teeth) and a positive family history of ectodermal features. Given the inconclusive early radiographic findings, whole-exome sequencing (WES) was utilized. WES revealed the proband carried a heterozygous EDARADD variant (NM_080738:c.328G>T; p.Asp110Tyr). Subsequent familial segregation analysis identified an additional heterozygous WNT10A variant (NM_025216:c.637G>A; p.Gly213Ser) within the broader family. The EDARADD variant alone was associated with varying presentations from normal dentition to delayed eruption. Furthermore, the …

A Scientometric Study On Research Trends And Characteristics Of Tooth Intentional Replantation, Yan Zhou, Simin Deng, Wenhua Xu, Wei Liu, Yibo Guo, Mingyi Zhu

Journal of Dental Sciences

Background/purpose: Intentional replantation is regarded as a final strategy to preserve natural teeth affected by inaccessible endodontic and periodontal disease. The purpose of this study was to analyze the scientometric characteristics and research trends of tooth intentional replantation.

Materials and methods: All the papers on intentional replantation were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2017 and after 2017 in the analysis of research trends.

Results: There were 356 papers on intentional replantation, with total citations of 5562 and the h index of 42. The trend of bone substitutes, boron …

Dance Improvisation And Kinematics: Describing Spontaneous Motion Among Movers, Fallon Simone Doshi Brackley

Student Scholarship

No abstract provided.

Development Of An Enantioselective Synthesis Of (–)-Euonyminol And Studies Towards The Total Synthesis Of (–)-Lomaiviticin A, Zhi Xu

Yale Graduate School of Arts and Sciences Dissertations

In the first chapter, I describe the development of the first enantioselective synthesis of (–)-euonyminol (1), a heavily oxidized sesquiterpenoid. Structurally, (–)-euonyminol (1) features a tricyclic framework containing an all-carbon quaternary center and nine free hydroxyl groups. Following the initial failed attempts to achieve a semi-pinacol rearrangement of an allylic silyl ether, we developed a novel oxyalkylation reaction to establish the C10 quaternary center of 1. From this intermediate, we investigated three distinct strategies to construct the tricyclic framework of 1 employing a reductive cyclization, an aldol–dehydration sequence, and a radical cyclization reaction, respectively. Finally, a series of stereoselective transformations …

'Typical Cases': Representation, Racializing Medicine, And The Politics Of The Case Study In The Moulages Collections Of The Hôpital Saint-Louis, Kathleen Pierce

Art: Faculty Publications

Physicians at the hôpital Saint-Louis prized their collection of wax models (moulages) for their precise representation of color: a central project of dermatology. Close looking at the collection, however, reveals the repeated use of a consistent light skin tone across the vast majority of models. Given physicians’ investment in chromatic precision, how might we understand this generic attention to skin coloration? “Typical Cases” asks how, when, and why skin pigmentation mattered to fin-de-siècle dermatologists. I first argue that the overrepresentation of light skin tones comprises an aesthetic choice made by the model-makers and their physician-patrons. I subsequently ask how this …

Beyond The Glass Ceiling: Career Advancement Strategies For Mid-Level Women In Student Affairs, Jalonda N. Thompson

Journal of Higher Education & Student Affairs

The purpose of this paper is to provide an overview of the literature on the push and pull factors that influence women’s choices to either opt in or opt out of career advancement in student affairs (Coetzee & Moosa, 2020; Harman & Sealy, 2017). Women, specifically Black women, are underrepresented in Senior Student Affairs Officer (SSAO) positions in higher education (American Council of Education, 2024). As the demographics of the United States (US) change, student affairs is at a critical point to foster an inclusive learning environment that reflects the increasing racial and ethnic diversity in the US (Lopez, 2006). …