Digital Commons Network^™

Thyroid Peroxidase Antibody (Tpo Ab) Can Be Used As A Marker For Persistence Of Symptoms Of Hypothyroidism In Patients With Primary Hypothyroidism Despite Normal Tsh Level: Cross-Sectional Study, Gehad Mohamed Aldamsisy, Mohamed Ghoniem Mohamed, Mohammed Mofreh, Ahmed Albehairy

Mansoura Medical Journal

Background Primary hypothyroidism is one of the most prevalent endocrine conditions. Some hypothyroid patients treated with an acceptable dose of levothyroxine report continuing symptoms including fatigue, depression, and weight gain, despite having a TSH level in the lower half of the normal range. Aim to evaluate why some hypothyroid patients on levothyroxine continue to have residual symptoms despite apparently adequate replacement& laboratory euthyroid status? Patients and methods 111 Adult male and female ranging from (18-65) years with primary hypothyroidism and normal TSH taking adequate levothyroxine dose were divided into 2 groups. Group1: Hypothyroid patients with persistent symptoms despite normal TSH …

Relationship Between Serum Micro-Rna 192 And 29c And Kidney Disease In Subjects With Type 2 Diabetes Mellitus, Amr Y. El Feky, Talaat A. Abdelaaty, Azza A. Ismail, Rania M. Elsharkawy, Mohamed F. Amara, Shimaa M. Elrahmany

Mansoura Medical Journal

Background Diabetic kidney disease (DKD) is a frequent and serious complication of type 2 diabetes mellitus (T2DM). This study aimed to assess the relationship between micro- RNA (miRNA)-192 and miRNA-29c expression and DKD in patients with T2DM. Patients and methods A case-control study was conducted with 160 participants: 40 T2DM patients with DKD, 40 T2DM patients without DKD, and 80 healthy controls. Plasma levels of miRNA-192 and miRNA-29c were quantified using quantitative reverse transcription PCR. Diagnostic accuracy was assessed via ROC curve analysis. Multivariate logistic regression identified predictors of DKD. Results Micro RNA-192 expression was significantly elevated while miRNA-29c expression …

The Effect Of Parathyroidectomy Compared To Pharmacological Treatment On Biochemical Markers And Quality Of Life Among Maintenance Hemodialysis Patients With Secondary Hyperparathyroidism, Ahmed Bahie, Dina Abd El Halim Shahin, Magdy Elsaid Abd Elmagid Samour, Elshahat Ali Ahmed Mohamed Yousef

Mansoura Medical Journal

Background One-third of maintenance hemodialysis (HD) patients develop severe secondary hyperparathyroidism (SHPT). Parathyroidectomy (PTx) is recommended for resistant SHPT, but calcimimetics have reduced the need for surgery. Aim of the work: to compare biochemical and QoL parameters in HD patients with SHPT who underwent PTx to those treated medically. Subject and methods in a cross-sectional study, 200 maintenance HD patients in two equal groups: A (patients on medical treatment) and B (PTx patients). In Group A, 32 patients received Cinacalcet. A thorough history, anthropometrics, clinical examination, Electrocardiography and full laboratory tests including serum calcium (sCa), phosphorus (sPhos), intact parathormone (iPTH) …

Antifibrotic Effects Of Fucoidan Compound On Experimental Hepatic Schistosomiasis, Eman Alaa Eldin Nazir Mohamed, Nairmen Nabih Ahmed, Suzan Hassan Elgendy, Zeinab Mohamed Ahmed Gawesh, Soha Ibrahim Awad

Mansoura Medical Journal

Background Schistosomiasis is a prevalent fibrotic disease characterized by inflammation and fibrous tissue deposition around Schistosoma eggs trapped in the hepatic tissue. This work aimed to evaluate the anti-fibrotic and anti-parasitic effects of fucoidan during the chronic phase of experimental schistosomiasis-mansoni in mice. Methods Sixty female Swiss albino mice were allocated into six groups; non-infected unmanaged mice group, infected unmanaged mice group, non-infected fucoidanmanaged mice group, infected fucoidan-managed mice group, infected PZQ-managed mice group, and infected combined fucoidan and PZQ managed mice. Every liver tissue was examined parasitologically, histopathologically, and by anti-transforming growth factor-beta (TGF-β) immunohistochemically. Serum was used to …

St-Segment Resolution As A Predictor Of Short-Term Clinical Outcomes In Patients With Acute Anterior St-Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention, Mohamed Ali Nada, Eid Mohamed Daoud, Ahmed Mohamed Reda

Mansoura Medical Journal

Background: Acute anterior ST-elevation myocardial infarction (STEMI) carries a high risk of adverse outcomes despite advances in reperfusion therapy. ST-segment resolution (STR) on electrocardiography has been proposed as a simple marker of myocardial reperfusion and predictor of clinical, but its prognostic role in routine practice remains debated. Aim of the Work: To assess the efficacy of ST-segment resolution as a predictor of short-term clinical outcomes in patients with acute anterior STEMI undergoing primary percutaneous coronary intervention (PCI). Patients and Methods: A prospective observational study was conducted at Mansoura University Cardiology Department between January and June 2024. 98 patients with anterior …

Interleukin-38 Serum Level In Nonsegmental Vitiligo Patients And Its Correlation With Disease Activity And Disease Severity, Aya Adel, Mohammed El- Kamel, Manar Ali Hassan

Mansoura Medical Journal

Background Vitiligo is a multifactorial disease in which autoimmunity plays a central role. Interleukin (IL)-38, an innate immune cytokine secreted by keratinocytes and other cells, is believed to have a role in vitiligo progression. Aim To assess the serum levels of IL-38 in cases with non-segmental vitiligo and to examine its correlation to disease severity and disease activity. Methods This case control study included 60 patients with vitiligo and 20 healthy subjects as a control group. According to the disease severity, the cases were allocated into three groups: mild, moderate and severe. Each group included 20 patients. The affected body …

The Association Between Stress-Related Disorders And Chronic Pelvic Pain Syndrome In Males: A Narrative Review, Abdinur Jama Farah, Mohammed Hegazy Abdulhalem, Wafaa Abdel-Hakim El-Bahaey, Ahmed Sobhy El Hefnawy

Mansoura Medical Journal

Background Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) in males is a multifactorial clinical syndrome with significant impact on quality of life (QoL). Objective To explore the link between psychological stress and chronic pelvic pain in males through reviewing the relevant articles in CPPS literature. Review summary CPPS in males is a complex condition marked by persistent pelvic pain, urinary symptoms, and sexual dysfunction without identifiable infection or pathology. Its unclear etiology and significant impact on quality of life make it a challenging clinical problem. Growing evidence suggests that psychological stress plays a key role in symptom onset and persistence by …

Evaluation Of Serum Ischemia Modified Albumin Level In Male With Androgenic Alopecia, Eman Elnigomy Mahmoud Elnigomy, Fawzia Ameen Saafan, Noha Mohamed Sherif Salah, Mohammed Samir Sultan

Mansoura Medical Journal

Introduction Androgenic alopecia (AGA) is the most common type of progressive hair loss in men, influenced by genetic and hormonal factors. Recent studies suggest that oxidative stress may play a role in its pathogenesis. Serum ischemia-modified albumin (IMA), a biomarker of oxidative stress, could provide insights into disease activity and severity in AGA patients. Aim The purpose of this study was to evaluate serum level of ischemia-modified albumin in male patient with androgenetic alopecia in comparison with healthy control. Patients and Methods This case-control study included 45 male patients with androgenetic alopecia and 45 age- and sex-matched healthy controls, recruited …

Interplay Between Amiodarone And Statins: Experimental Evidence Of Synergistic Hepatotoxicity, Hager Zaki Elghareb, Abdel-Motaal M. Fouda, Mohamed Mahmoud Elhadidi, Ahmed Abdel-Monem Elmetwally

Mansoura Medical Journal

Background: Drug-induced liver injury (DILI) continues to be a main contributor to acute liver failure. So, this study aimed to investigate interactions between amiodarone and atorvastatin concerning hepatic safety, due to increasing clinical practice of their combination for optimal arrhythmia control. Methods: Forty male Sprague Dawley rats were randomly divided into four groups (10 in each group). Group 1 was control group receiving normal saline. Group 2 received Amiodarone-only \ (administered 30 mg/kg/day orally). Group 3 received Atorvastatin only (administered 10 mg/kg/day orally). Group 4 received combination of both amiodarone and atorvastatin in same previous doses. All drugs were dissolved …

Comparison Of The Efficacy Of Topical Cetirizine 1% Versus Topical Minoxidil 5% Solution In Treatment Of Male Androgenetic Alopecia, Hadeer Samy Abd-Elfattah, Bothaina Mahrous Ghanem, Farid Abd-Elreheim Badria, Mohammed Samir Sultan

Mansoura Medical Journal

Background: Androgenetic alopecia (AGA) is a common form of non-scaring hair loss characterized by extensive miniaturization of scalp hair follicles. Minoxidil is a standard topical treatment. Cetirizine, an antihistamine with anti-inflammatory properties, may be beneficial by modulating prostaglandins—specifically by inhibiting PGD2 and promoting PGE2, both of which have essential roles in hair cycle regulation. Aim: To compare the efficacy and safety of topical cetirizine 1% versus minoxidil 5% in treating male AGA. Patients and Methods: Forty male patients were randomly allocated in this randomized controlled study to receive topical cetirizine 1% or minoxidil 5%. Clinical photographs and dermoscopic evaluations were …

Evaluation Of Safety And Efficacy Of Autologous Platelet-Rich Fibrin In The Treatment Of Psoriasis Vulgaris, Hajar Esamelddin, Maha Elgyyar, Mohamed Sultan

Mansoura Medical Journal

Background: Psoriasis is a chronic, immune-mediated dermatosis characterized by dysregulated cutaneous immunity. Platelet-rich fibrin (PRF), an autologous biomaterial concentrated with immunomodulatory cytokines and growth factors, presents a potential novel therapeutic approach by modulating localized inflammatory pathways. Objective: This study aimed to assess the efficacy and safety of a topical and intralesionally autologous PRF protocol in patients with localized plaque psoriasis. Methods: In a prospective single-arm trial, sixty adults with mild-to-moderate localized plaque psoriasis (BSA ≤10%, PASI ≤10) were enrolled. PRF was prepared from peripheral blood via low-speed centrifugation without anti-coagulant. Treatment involved bi-weekly intralesionally injections and topical massage of the …

Evaluation Of Serum Zinc-To-Copper Ratio In Adults With Type 2 Diabetes And Its Association With Microvascular Complications, Magdy H. Megallaa, Shimaa M. Elrahmany, Rehab Safwat, Mohamed Zietoun

Mansoura Medical Journal

Background Zinc (Zn) and copper (Cu) are indispensable trace metals that contribute fundamentally to insulin biology, antioxidant defense, and vascular health. In this research, we sought to explore the association between the serum zinc-to-copper (Zn/Cu) ratio and microvascular complications among adults diagnosed with type 2 diabetes (T2DM). Methods For this case-control design, a total of 336 participants were selected and divided into two main groups: Group 1, comprising 224 patients with T2DM, and Group 2, consisting of 112 healthy subjects serving as controls. Group 1 was further stratified into two subgroups based on the presence of microvascular complications; Group 1A …

Vitamin D Status In Coronary Artery Disease, Yasmeen M. Zayed, Hamdy F Marzouk, Alshaimaa H. Abd-Elmaksoud, Ahmed H. Eladawy, Shereen A Mourad

Mansoura Medical Journal

Background: Vitamin D deficiency, dyslipidemia, and systemic inflammation are recognized contributors to coronary artery disease (CAD), so the aim of this study was to assess association of serum vitamin D (25(OH)D), traditional and nontraditional lipid indices, and neutrophil lymphocyte ratio (NLR) with CAD risk and severity, and to evaluate their predictive value using the Gensini score. Methods: A cross-sectional study included 55 CAD patients (group I) and 55 age- and sex-matched individuals (group II). lipid profiles, NLR, and serum 25(OH)D levels were measured. Nontraditional lipid indices, including Castelli’s Risk Indices and atherogenic coefficient were calculated. The severity of CAD was …

Low-Carbohydrate, Low-Fat, And Balanced Diets In Weight Reduction Among Obese Adolescents., Ashraf A. Elsharkawy, Gihan Fouad Ahmad, Ahmed El-Husseiny, Amany K. Elhawary, Ola Shawky Ahmed, Asmaa Taha Zaher Taha, Fatma El-Zahraa M. Hashish

Mansoura Medical Journal

Background: Obesity in adolescents is a major public health concern, leading to early onset of metabolic abnormalities. This study aimed to compare the effects of the Low- Carbohydrate Diet (LCD) and Low-Fat Diet (LFD) in comparison with the balanced calculated diet (BCD) on weight reduction in obese adolescents and their impact on metabolic health markers. Patients and methods: 75 obese adolescents aged less than 18 years were enrolled in this prospective, randomized, controlled study and were randomly assigned to either LCD group, LFD group, or BCD group. Anthropometric and laboratory measures were collected before and after a 10-week intervention. Results: …

Indications Of Hospitalization And Predictors Of Outcome Among Patients With Rheumatological Diseases Admitted To Mansoura Rheumatology And Immunology Unit, Hanan Mohamed Elberashi, Nibal Morad, Samar Tharwat

Mansoura Medical Journal

Background correction: Systemic autoimmune rheumatological diseases (SARDs) constitute a category of disorders that can affect several organs. SARDs are persistent, incapacitating illness characterized by significant morbidity and mortalityrates. Patients with SARDs necessitate hospitalization more frequently than the general population.

Aim: To determine the characteristics of patients hospitalized with SARDs at Mansoura University Hospital.

Materials and methods: This cross-sectional study was carried out on patients with different SARDs. The collected data

included patients’ sociodemographic data, autoimmune disease diagnoses, the onset and duration of the disease, rate of

readmission, the main cause of admission, the main organ affected at time of admission, …

Effect Of Autologous Nanofat Injection In Post-Traumatic Atrophic Scars: A Prospective Randomized Interventional Clinical Study, Ghada M. Hammad, Manar Sallam, Sherif R. Ismail, Ahmed M. Zenia, Shereen Ezzalregal Alashry

Mansoura Medical Journal

Background Post-traumatic scars continue to be a challenging issue for both patients and surgeons. Nanofat, a novel tool in regenerative medicine, relies primarily on adipose-derived stem cells (ADSCs). These cells aid in wound healing by promoting angiogenesis and secreting growth factors that help decrease inflammation and fibrous tissue formation. Aim of the study To assess the aesthetic results of autologous nanofat injection in post-traumatic atrophic scars. Patients and methods 30 cases with post-traumatic atrophic scars received a single session of nanofat injection. Evaluation was done 3 and 6 months after the session using the Vancouver scar scale. Results Our study …

Understanding Women's Access To And Utilization Of Syringe Service Programs, Annelisa E. Swiersz

Honors Undergraduate Theses

As of 2020, 138 million Americans ages 12 and over reported illicit drug use in their lifetime, with over 3 million of those people injecting drugs. There are risks for all people who use drugs, but people who inject drugs (PWID) pose specific risks such as hepatitis B, hepatitis C, and human immunodeficiency virus (HIV), with women who inject drugs (WWID) facing even more risks. WWID involved in sex work have a higher risk of HIV transmission and lack access to sterile injection devices and sexual and reproductive health services. To address these risks, syringe service programs (SSPs) were developed …

Adverse Childhood Experiences And Working Memory, Lake Miller

Honors Undergraduate Theses

Extensive research has shown that adverse childhood experiences (ACEs), such as sexual abuse, poverty, physical abuse, emotional abuse and neglect, can negatively impact an individual’s development. The presence of ACEs has also been linked to an increase in one’s engagement in risky behavior, dropping out of school, unemployment before the age of 21, and a variety of health issues. Currently, there is a gap in literature regarding the performance of different working memory (WM) tasks and the presence of ACEs. This study focuses on filling this gap in literature by measuring participants’ Philadelphia ACE score, which is a 16-item questionnaire, …

Understanding Emergency Department Utilization By African Americans For Routine Diabetes Care: Are We Asking The Right Cultural Questions?, Melissa Scollan-Koliopoulos

Nursing Faculty Publications

Introduction: The emergency department is a source of routine care for many African Americans. Afrocentric cultural characteristics may serve as a better proxy than race for understanding preferences for emergency department use over primary care for diabetes management. Methods: A literature review was conducted including key terms related to transitional healthcare, emergency department recidivism, Afrocentric cultural characteristics, racism and health disparities, and diabetes in African Americans. An example of tailoring talking points using Afrocentric cultural characteristics is proposed using Jone’s TRIOS Model, a Afrocentric Self-enhancing and Protective Theory. Results: The literature includes evidence to support a complex explanation for emergency …

Testing The Antigenic Potential Of Transmembrane Proteins To Develop A Thermostable Tuberculosis Mof-Liposomal Vaccine, Sneha Kumari, Jonathan Martinez-Garcia, Ryanne Nicole Ehrman, Wendy Tang, Joshua Miles, Priyanka Basak, Thomas Sinclair Howlett, Yalini Hansika Wijesundara, Ziqi Wang, Blanca I. Restrepo

School of Medicine Publications

Tuberculosis is one of the deadliest infectious diseases and continues to be a major health risk in many parts of the world. Even today, the century-old Bacillus Calmette-Guerin (BCG) vaccine is the only formulation on the market and is ineffective for several sections of the global population responsible for transmission. In the search for antigens that can mount a robust immune response, we have reported the recombinant expression and purification of two novel membrane proteins, the Cation transporter protein V (CtpV) and the Mycobacterial copper transporter B (MctB) present on the membrane surface of Mycobacterium tuberculosis. CtpV was tested …

Clinical Criteria For Limbic-Predominant Age-Related Tdp-43 Encephalopathy, David A. Wolk, Peter T. Nelson, Liana Apostolova, Konstantinos Arfanakis, Patricia A. Boyle, Cynthia M. Carlsson, Nick Corriveau-Lecavalier, Penny Dacks, Bradford C. Dickerson, Gladys E. Maestre

School of Medicine Publications

Limbic predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is highly prevalent in late life and a common co-pathology with Alzheimer's disease neuropathologic change (ADNC). LATE-NC is a slowly progressive, amnestic clinical syndrome. Alternatively, when present with ADNC, LATE-NC is associated with a more rapid course. With the emergence of anti-amyloid therapeutics, discrimination of LATE-NC from ADNC is critical and will lead to greater clinical recognition of amnestic patients without ADNC. Furthermore, co-pathology with LATE-NC may influence outcomes of these therapeutics. Thus there is a need to identify patients during life with likely LATE-NC. We propose criteria for clinical diagnosis of …

Enhancing Bone Regeneration Using Kaempferol As An Osteoprotective Compound: Signaling Mechanisms, Delivery Strategies, And Potential Applications, Mojdeh Salehi Namini, Sanam Mohandesnezhad, Sadaf Mohandesnezhad, Vahid Mansouri, Lobat Tayebi, Nima Beheshtizadeh

Electrical & Computer Engineering Faculty Publications

Various plants, including fruits, vegetables, and spices, contain kaempferol, a bioflavonoid compound with diverse medicinal effects, such as antioxidant, antibacterial, and anti-inflammatory characteristics. Furthermore, this compound exhibits multiple health-promoting properties, including osteoprotection and osteogenesis, primarily by modulating various cell-signaling pathways. This review aims to illustrate the medical advantages of kaempferol and its role in regulating bone metabolism through cell signaling mechanisms. Numerous studies have demonstrated the bone-protective properties of kaempferol and its encapsulated form. Further research is needed to clarify the optimal dosages, toxicity, safety, and other potential mechanisms of action. This review demonstrates that several signaling pathways, including nuclear …

Revisiting Patent Linkage, John R. Thomas

Georgetown Law Faculty Publications and Other Works

Alfred Engelberg’s article of a quarter-century ago, Special Patent Provisions for Pharmaceuticals: Have They Outlived Their Usefulness?, raised a provocative question that retains currency today. The special provisions that Hatch-Waxman established, and Engelberg addressed, have come to be known as patent linkage. Following the principle of linkage, the Food and Drug Administration (FDA) cannot approve generic drugs for marketing if they would infringe a patent.

Hatch-Waxman’s complex patent provisions aspire towards multiple salutary purposes, including encouraging the prompt availability of generic drugs, improving public notice of pharmaceutical patents, and accelerating dispute resolution proceedings. Congress also attempted to ameliorate perceived …

Climate Change And Constitutional Overreach, Jonathan H. Adler

Faculty Publications

The failure of the political process to produce meaningful climate mitigation policies has encouraged activists to pursues aggressive and innovative litigation strategies. An increasing number of climate-related lawsuits seek to control greenhouse gas emissions, impose liability on fossil fuel producers, or otherwise force greater action on climate change. In many of these cases, litigants have made aggressive constitutional claims that stretch the bounds of existing constitutional doctrine and threaten to entrench climate policies outside of the traditional political process. This Article critically assesses some of the constitutional arguments made in climate cases, including Massachusetts v. EPA and Juliana v. U.S. …

Bride V. Snap, Central District Of California

Historical and Topical Legal Documents

No abstract provided.

Islam, Memory, And Denial: Preserving Bosniak Identity After The Srebrenica Genocide, Alek Barović

Occasional Papers on Religion in Eastern Europe

The role of the Bosniak Islamic Community in preserving identity and collective memory of the Srebrenica genocide remains a subject of ongoing debate among Bosniaks in Bosnia, the wider Balkan region, and the diaspora. This paper explores how Bosniaks perceive the Islamic Community’s efforts in shaping and sustaining post-genocide identity through religious, cultural, and educational initiatives. By analyzing narratives from survivors, religious leaders, and community members, this study investigates whether the Islamic Community is seen as a central institution in the preservation of historical memory or as one actor among many in the broader struggle against denial and historical revisionism. …

Review: Out Of The Mouths Of Babes: Infant Voices In Medieval French Literature, Alani Hicks-Bartlett

Quidditas

Voicing a stirring call for readers to reconsider the silence and lacunae that are traditionally attributed to infancy, in her latest monograph, Julie Singer situates infancy as both an essential critical framework and an instructive, illuminative methodology through which a gaping archival silence can be rectified-that silence being literary representations of the medieval child, and specifically, the spoken life of the medieval child. As Singer argues, infancy and childhood entwine rather indiscernibly with each other in accordance with the medieval attribution of a longue dureé to infancy (Isidore of Seville, for instance, posited infancy as a stage lasting for about …

"Being Therefore Perfect" Matthew 5:48 In Modern Restoration And Ancient Jewish Contexts, Trevan G. Hatch, Gerrit Van Dyk

Religious Educator: Perspectives on the Restored Gospel

Matthew 5:48 (“Be ye therefore perfect . . . ”) is a salient passage of scripture for Latter-day Saints because of its seeming focus on becoming like God, a key doctrine of the Latter-day Saints faith. But what insights do we gain from analyzing its ancient Jewish context by comparing it to a parallel verse in Luke 6, by examining the verses immediately preceding it, and by considering the Greek grammar of the passage and the ancient meaning of the word translated as perfect in its various contexts? This essay explores these interpretive angles as well as survey show this …

Contesting "Address": Conflicts Over The Words We Use To Address And Refer To Each Other, Helen Norton

Publications

Professor Richard Brooks's generative insights provide us with valuable tools for recognizing, and trying to make sense of, address's role in human interactions. That "address"--the words we use to address and refer to each other--has the potential both to offer value and to inflict harm to these interactions sometimes triggers conflict over appropriate forms of address. In this Commentary to Professor Brooks's Frankel Lecture, I examine some of these conflicts.

As we'll see, some address conflicts involve debates over whether and when address actually makes meaning or whether it’s instead relatively trivial--while others involve contestants who agree that address makes …

Transgender Disenfranchisement, Scott Skinner-Thompson

Publications

Transgender and gender variant people are excluded from formal democratic participation at the polls through a variety of legal mechanisms. Such barriers include purportedly neutral voter identification laws, which may prevent transgender people from voting given the obstacles to achieving accurate identification documents in many states, and felon disenfranchisement laws, which exclude the disproportionate number of trans people ensnared in the carceral system.

But, as this Article explains, transgender people are also deterred from public space and participation more broadly through laws and customs specifically policing gender identity. Such laws include so-called bathroom bills that prevent people from accessing facilities …