Digital Commons Network^™

Hillslope Degradation: Coarse Sands May Move Faster But Fines Dominate Flux, Robert Chance

Theses and Dissertations

Hillslopes are one of the most pervasive landforms on Earth yet the details of the processes that drive their evolution are not completely understood. Excluding boulders, the majority of mass and volume in soil-mantled hillslopes is composed of sand-sized and finer grains. Understanding the transport rates and governing transport mechanisms of these grains is therefore key to advancing our knowledge of hillslope evolution.This research investigates sand-sized sediment transport through field experiments at 20 sites tracking surface sediment motion and 11 sites measuring depth-dependent transport. These empirical results are compared against outputs from a novel grain-based hillslope diffusion simulation (GBHDS), which …

Assessment Of Medical Laboratory Science Student Motivation And Perceived Transfer Of Knowledge Towards Information Literacy, Shannon Jongeward

Theses and Dissertations

Information literacy skills are a cornerstone of higher education as they allow students to effectively locate, evaluate, and utilize information from various sources. Evidence-Based Practice, a process commonly used in healthcare for decision making, incorporates using the best available research, one’s clinical expertise, and the patient’s values. Information literacy is foundational to developing evidence-based practice skills. Medical Laboratory Scientists (MLS) utilize evidence-based practice to assist in making decisions about clinical laboratory tests and processes to ensure quality in testing and the appropriate use of resources; therefore, it is important for MLS programs to include elements of evidence-based practice into their …

The Roles Of Readily Releasable Stores Of Endolysosome Iron In The Pathogenesis And Treatment Of Alzheimer's Disease, Darius N.K Quansah

Theses and Dissertations

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized clinically as progressive decline in cognition and dementia. Pathologically, AD is characterized by the extracellular presence of senile plaques composed of accumulated amyloid beta (Aβ) proteins and intraneuronal accumulation of neurofibrillary tangles composed of hyperphosphorylated tau proteins. In addition to these pathological hallmarks, AD pathogenesis is characterized by increases in intracellular iron and reactive oxygen species (ROS) and the link between the two have been well described by Fenton’s chemistry. Endolysosomes appear to be affected very early in the onset of AD. Endolysosomes contain labile stores of iron which can be readily …

Ecological Dynamics In Beaver-Engineered Boreal Wetlands: Amphibian Phenology, Occupancy, And Aquatic Macroinvertebrate Communities, Talon Stammen

Theses and Dissertations

Boreal wetlands are ecologically rich yet vulnerable ecosystems shaped by hydrological dynamics, cold climate regimes, and landscape-scale disturbances. Among the most influential agents of change in these systems are beavers (Castor canadensis), whose engineering activities create a mosaic of lentic habitats at varying stages of ecological succession. This dissertation investigates the structure and dynamics of amphibian and aquatic macroinvertebrate communities across a beaver-influenced wetland landscape in Voyageurs National Park, Minnesota, USA.The first study (Chapter II) examines breeding phenology and detection patterns of boreal anurans using a combination of passive acoustic monitoring and visual encounter surveys at 25 wetlands over four …

Zaasijiwan: An Indigenized Health Communication Framework For American Indian And Alaska Native Communities, Jennifer Wolf

Theses and Dissertations

The Zaasijiwan Framework represents an Indigenized health communication model developed to enhance the cultural relevance, trust, and effectiveness of public health messaging for American Indian and Alaska Native (AI/AN) communities. This qualitative study integrated Indigenous and Western public health knowledge to inform the development of the framework. A comprehensive literature review and two rounds of key informant interviews with health communication professionals informed the design of the framework. Findings emphasized the importance of community co-creation and strengths-based narratives, along with other framework elements, in overcoming medical mistrust and improving health outcomes. The final framework offers public health professionals, Tribal, and …

Pediatric Cancer Incidence, Temporal Trends, And Mortality In The United States By Health Disparities Indicators, Seer (1973-2014), Prachi P. Chavan, Laurens Holmes Jr.

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Background: Pediatric cancer incidence has been increasing in the United States, despite improvement in pediatric cancer survival. This steady increase in incidence trends is not completely understood but maybe associated with social and environmental factors. In this study we aimed to assess the cumulative incidence, temporal trends, and mortality rates in pediatric cancer. Additionally, we examined sub-group variability in both incidence and mortality rates. Methods: Data from Surveillance, Epidemiology, and End Results (SEER) −18 from 1973–2014 were used for the purpose of analysis in this study. Age-adjusted incidence rates were used to assess temporal trends in cancer among children aged < 1–19 years. Univariable and multivariable binomial regression models were used to examine the association between race and cancer mortality while adjusting for potential confounders. Results: There were 92,594 cancer diagnoses during this period. White children comprised 74,758, (80.7%), black children 10,030, (10.8%), and other races 6648, (7.2%). Overall the age-adjusted cumulative incidence was slightly higher among white children (16.4%) than black children (12.4%) and other (13.0%). Children aged 15–19 years and those in metropolitan regions were more likely to be diagnosed with pediatric cancer. Relative to females, males were 16% more likely to die from the disease [adjusted Risk Ratio (aRR): 1.16, 95% Confidence Interval (CI): 1.09–1.22]. Additionally, compared to white children, black children had higher mortality rates [(aRR): 1.37, 99% CI: 1.23–1.52]. Conclusions: There is an increasing trend in pediatric cancer incidence; while white children have the highest incidence, black children and males indicated a survival disadvantage, indicative of racial and sex variability in overall pediatric cancer in the United States.

Predictors Of Donor-Site Wound Complications Following Fibula Free Flap Reconstruction, Soroush Ershadifar, Angela Colback, Ugur Nur Basmaci, Machelle Wilson, Andrew C Birkeland, Dustin A Silverman

Faculty, Staff and Student Publications

Objective: The fibula free flap (FFF) remains the workhorse flap for head and neck defects necessitating osteocutaneous reconstruction. Although lower extremity angiography, ultrasound (US), and other vascular studies are routinely used for fibula assessment and patient selection, predictors of donor-site morbidity following harvest remain poorly understood. We sought to investigate the factors associated with FFF donor-site complications.

Study design: Retrospective analysis of patients at a tertiary care center.

Setting: Tertiary care center.

Methods: In total, 119 patients undergoing FFF reconstruction during the years 2012 to 2022 were included. Multivariable logistic regression was used to identify independent predictors of soft-tissue donor-site …

Gadd34 And Crep Regulation In The Unfolded Protein Response, Comparing Molecular Mechanisms In Humans And Zebrafish, Angela Adams

University of the Pacific Theses and Dissertations

In eukaryotic cells, many newly synthesized proteins are sent to the endoplasmic reticulum (ER) of a cell to be folded into the proper conformation for functionality. When proteins get misfolded, or cannot be folded fast enough, these proteins accumulate in the ER which causes the cell to become stressed. This leads to a process known as the Unfolded Protein Response (UPR). Once UPR has been initiated, the α subunit of eukaryotic initiation factor 2 (eIF2α) becomes phosphorylated to inhibit global protein synthesis within the cell, while simultaneously activating the expression of several genes to either aid in cell recovery or …

Knocking On Resistance’S Door: Investigating The Spread And Drivers Of Kdr Mutations In Northern California Culex Tarsalis, Esther Blankenship-Cutshall

University of the Pacific Theses and Dissertations

Vector-borne diseases are an increasingly relevant threat to public health as climate change alters the ecology of vector populations in relation to humans. One key to combating vector-borne disease is using pyrethroid insecticides against mosquito populations. However, wild mosquito populations have exhibited resistance to those key pyrethroids. One resistance mechanism under investigation is the altering of the voltage-gated sodium channel, which is associated with the genetic mutations known as kdr. The prevalence and history of kdr mutations has been investigated in some populations of Culex pipiens, however, it is unknown in northern California Culex tarsalis populations. This study aims to …

The Changing Nature Of Outdoor Play Spaces In West Australian Primary Schools: An Exploratory Case Study. Exploring Play Opportunities, Design And Utilisation Of An Intentionally Designed Nature Play Space (Idnps)., Catherine Fitzhardinge

Theses

The development, wellbeing and learning of children is of global importance; opportunities that promote healthy childhood development have long lasting social and economic impacts. Play is the primary occupation through which children develop; nature play provides opportunities for physical, cognitive, social and emotional skill development. West Australian (WA) schools are installing intentionally designed nature play spaces (IDNPS) to support outdoor play opportunities and connection to nature. However, there is little contextual evidence regarding how these spaces are designed and utilised to support child development, wellbeing and learning.

This exploratory, mixed methods case study examined how children aged 4-7 years old …

Slaying The Windigo: Fear And Faith In The Anthropocene, Daniel J. Irwin

Graduate Student Theses, Dissertations, & Professional Papers

This thesis examines the changing affect of fear in the environment and how it is influencing writing in the Anthropocene. Chapter one lays the groundwork for the present moment of ecocriticism, examining how the relationship with the environment has changed throughout the history of ecocritical writing. The second chapter examines how fear has been an intrinsic element of environmental storytelling, starting with the romantic ideas of the sublime. With the recognition of the impact that humanity has had on Earth over the past several centuries, and the accelerating acceptance of the idea of the Anthropocene since the turn of the …

Social Connection And Disability: A Longitudinal Experimental Study Of Intervention Effectiveness And Moderators, Krys Standley

Graduate Student Theses, Dissertations, & Professional Papers

Background: Social disconnection is an epidemic-level problem that is exacerbated for people with disabilities. There is a pressing need for theory-based research to illuminate the factors that contribute to effective interventions for improving social connection in this population.

Objectives: The objectives of this study were 1) to test the hypothesis that the Peer Collective, a six-week, online, group-based intervention centered on social support topics, would result in increased levels of social connection among community-dwelling adults with any types of disabilities and 2) to examine potential moderating effects in this hypothesized relationship.

Method: A longitudinal intervention study design with random assignment …

On Creating Bog Bodies: The Effects Of Ph Value On Dna Decomposition In A Bog Environment, Gabrielle B. Giangreco

Graduate Student Theses, Dissertations, & Professional Papers

Bog bodies have been a consistent area of interest in both archaeology and biological anthropology, due to their high rates of physical preservation. While there are many physical analyses that have been done on these remains, DNA analysis is lacking. Most studies focus on changes to the remains themselves or attempt to determine why they were placed in a bog. This study aims to examine the effects of pH level on the breakdown of DNA on remains placed inside a bog along with any larger differences in the preservation of the remains. The results of this study seem to point …

Membrane Reactor Modeling And Optimization For Hydrogen Production, Ayooluwa Tomiwa Akintola

Graduate Theses, Dissertations, and Problem Reports (ETD)

There has been an ongoing trend toward cleaner fuels for more environmentally benign forms of energy generation. Recently, hydrogen has been identified as a clean fuel for energy generation. However, the most established, efficient, and widely utilized technique for producing hydrogen remains the steam methane reforming (SMR) in the presence of catalyst. Unlike other fossil fuels, utilizing methane from natural gas in an SMR process to produce hydrogen emits less, but yet a notable sum of carbon dioxide. Furthermore, the endothermic nature of SMR reactions imply that there is a high energy requirement to obtain a substantial amount of hydrogen …

The Abuse Liability Of Oral Nicotine Pouches In Electronic Cigarette Users, Jakob D. Bohland

Graduate Theses, Dissertations, and Problem Reports (ETD)

Oral nicotine pouches (ONPs) are products containing synthetic or tobacco derived nicotine in a cellulose pouch. While relatively novel in their current state, ONPs are increasing in popularity, with little known about their national level prevalence. Extant work has suggested that electronic cigarette (e-cig) users may be interested in ONPs; however, no abuse liability studies have been conducted comparing ONPs directly to e-cigs. In the few abuse liability studies that have been conducted, ONPs have been evaluated in comparison to combustible cigarettes or smokeless tobacco (SLT). These studies suggest ONPs may be less reinforcing than combustible cigarettes or SLT. Therefore, …

Closing Racial And Ethnic Disparity Gaps In Pediatric Asthma Follow Up Care - A Quality Improvement Initiative, Ayodele Ayeko

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Closing racial and ethnic disparity gaps in pediatric asthma follow up care - A quality improvement initiative

Ayodele Ayeko

Introduction/Background: Inadequate management of asthma significantly contributes to poor asthma control, poor quality of life (QOL), and high hospitalization rates among pediatric patients. The Global Initiative for Asthma (GINA) guidelines offer recommendations designed to enhance asthma control and improve the quality of life for those affected (2015), including recommendations for close follow up care. At WVU Medicine Children’s Hospital (WVUMCH), insufficient asthma control has been associated with lower clinic follow-up rates and an increase in hospitalization. Although educational initiatives …

Beyond The Byproduct: Exploring Approaches For The Sustainable Valorization Of Underutilized Food Streams, Ian Phillip Israelsen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Commercial food processing creates side-streams that are often underutilized yet hold significant potential for valorization into value-added products for consumer use. This study investigated and compared potential protein recovery and lipid removal potential from buckwheat (BW; Fagopyrum esculentum Moench), brewer’s spent grain (BSG), and coffee silverskin (CSS) using a one-step solvent defatting and a pH-shift protein extraction method. The extraction efficiency yields of extracted protein from CSS were significantly lower than all other samples (p < 0.05). The defatted BW had the highest extracted protein content of all samples (p < 0.05). The sizes of the proteins in the starting materials were observed using LDS-PAGE. These sizes were consistent with published values and were mostly unchanged by defatting or the pH-shift process. The presence of 13S globulins and 2S albumins was confirmed under reducing conditions. Protein extracted from all native samples had lower total free essential amino acids than the starting materials. Native CSS and extracted protein followed this trend, but in defatted CSS and respective extracted protein samples, the extracted proteins had higher free essential amino acid content than the starting materials, sometimes of twofold or greater (p < 0.05). After defatting, the percentage of lipids recovered compared to the original lipid content of the samples was measured. The crude fat content of native and hexane-defatted BW flour was higher than BW flour defatted with ethanol (p < 0.05). The lipid extraction efficiency of all samples ranged from 4.6 ± 1.26%–43.20 ± 14.21%. The mass of the native and defatted starting materials were recorded at each step of processing, with reasonable losses assessed. The major non-polar lipid classes in each starting material were separated using thin-layer chromatography. All samples also displayed the presence of polar lipids. When comparing starting materials, BW and BSG was the most effective for protein extraction, and BSG has the most promise for lipid removal and potential for upcycling. All the examined starting materials show promise for use in food supplementation, especially as native flours. These products are plentiful and considered underutilized or side-stream products.

No Man’S A Stone: A Qualitative Approach To Characterizing Masculinity In Older Adulthood, Montgomery T. Owsiany

Graduate Theses, Dissertations, and Problem Reports (ETD)

Suicide rates are exceedingly high in U.S. older men (aged 65 years and older). In 2020, older men were about 6.5 times more likely to die by suicide than older women and 1.14 times more likely than men aged 18 to 64 years. Masculine norms (e.g., emotional suppression, self-reliance, anger, physical toughness risk-taking behaviors, alcohol misuse) are believed to influence the presentation of mental disorders, such as depression, which has led to the conceptualization of masculine depression. Research on masculinity often focuses on the experiences of younger men, ignoring how gender identities may change as one progresses through adulthood. Meanwhile, …

Community-Wide Impacts Assessment Of Silver Carp (Hypophthalmichthys Molitrix) In The Ohio River, Luka Marques

Graduate Theses, Dissertations, and Problem Reports (ETD)

Invasive species can cause measurable impacts on the properties of recipient ecosystems, with effects that often vary spatially and temporally. One of the most complex and pressing invasion cases in the United States involves invasive carp. Invasive carp have quickly expanded throughout the Mississippi River Basin, with ecological impacts that may vary across space and time. Silver Carp has the potential to provoke community-wide impacts on native fish abundances and food webs of native fish communities. My study area ranged from the confluence of the Mississippi River and the Ohio River to R.C. Byrd Lock and Dam. The Ohio River …

Functionalized Carbon Nanohoops: Synthesis, Structural Insights, And Pathways To Carbon Nanobelts, Liu Li

Graduate Theses, Dissertations, and Problem Reports (ETD)

The development of structurally defined carbon nanostructures has gained significant attention due to their unique electronic, optical, and mechanical properties. Cycloparaphenylenes (CPPs), also known as carbon nanohoops, and carbon nanobelts (CNBs) represent key molecular segments of carbon nanotubes (CNTs), offering a bottom-up approach to precise nanotube construction. This dissertation focuses on the synthesis, structural characterization, and functionalization of CPPs, as well as the development of novel synthetic pathways for CNBs. A series of functionalized CPPs, including [9]-, [12]-, [15]-, and [18]CPPs, were synthesized using a modular approach involving a Diels-Alder adduct formation followed by a Ni(cod)2/bpymediated macrocyclization reaction. The influence …

Co-Transmission Is Co-Opted For The Coordination Of Auditory Sensory Integration, Marryn M. Bennett

Graduate Theses, Dissertations, and Problem Reports (ETD)

Corollary discharge circuits (CDCs) are conserved mechanisms for sensory modulation during species specific behavioral programs. Many behaviors require multiplexed differential sensory modulation for proper execution. Co-transmission of fast and slow neurotransmitters allows for distinct modulation of different downstream targets within one sensorimotor circuit. However, studying co-transmission within the context of modulatory circuits like CDCs requires complete knowledge of behavioral circuits and precise tools for individually determining the implications of each transmitter on its targets. In this dissertation, I used a conserved set of corollary discharge interneurons in Drosophila melanogaster as a model to study the intricacies of sensory modulation through …

Artificial Intelligence Approaches For Membrane Fouling Prediction, Yazhou Jiang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Membrane fouling is a persistent and critical challenge in membrane-based separation processes, resulting in reduced performance, higher energy consumption, and increased operational and maintenance costs. Addressing this issue is essential for improving the long-term sustainability and efficiency of membrane systems. This report provides a comprehensive overview of membrane fouling mechanisms—such as organic, inorganic, particulate, and biofouling—and explores the growing role of Artificial Intelligence (AI) in tackling this problem. Specifically, it reviews three widely adopted AI techniques: Artificial Neural Networks (ANN), Fuzzy Logic (FL), and Support Vector Machines (SVM). Each method is examined through a series of literature-based case studies, …

Leveraging Physiological Signal Activity And Self-Report Data To Assess Students’ Trust In “My Friendly Mind” App And Its Impact On Their Mental Health Knowledge: A Mixed-Method Phase 1 Clinical Trial Focusing On Depression And Attention Deficit Hyperactivity Disorder From Human Factors Standpoint., Yeganeh Shahsavar

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mental health issues have become a significant global public health concern, especially among younger generations. The growing number of mental health challenges, combined with limited access to quality care, makes the problem even worse. Studies reveal that over 70% of individuals worldwide in need of mental health services do not receive appropriate care. Digital health technologies have the potential to enhance mental health services by making them more accessible and affordable. Despite the increasing popularity of mental health mobile applications (mHealth), there remains a lack of robust evidence of their effectiveness and the level of user trust, particularly in areas …

The Effect Of Carrier Type And Material Used On Results Of 1,1,1,2-Tetrafluoroethane Application To Teeth, Jonathon Logan Williams Dds

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: The formulation of a pulpal diagnosis is crucial to prescribe appropriate treatment recommendations for endodontics. The application of a cold stimulus to the tooth’s surface utilizing the refrigerant 1,1,1,2-Tetrafluoroethane (R-134a) is a common way to obtain a pulpal diagnosis. Cotton as a form of applicator is used to absorb the R-134a and create a temperature change in the pulp. There is limited research if there is a better material than cotton to generate this cold response. No studies to date have been found to determine if a sponge as an applicator would generate a more significant cold response than …

Evidence-Based Lighting Design For Healthcare: Health Effects Of Timed Blue-Light At Night (Blan) On Night-Shift Staff, Seyedeh Nazli Hosseini

Graduate Theses, Dissertations, and Problem Reports (ETD)

The effects of light at night on night-shift clinical staff in healthcare settings is a topic of growing significance, considering the widespread adoption of artificial lighting and the increasing prevalence of night-shift work in the healthcare industry. The intersection of neuroscience and architecture provides a unique lens to explore the intricate relationship between lighting conditions and the circadian hygiene of night-shift medical staff. This project investigates the strategies associated with light exposure schedules for staff during night-shift work in healthcare settings.

Exposure to artificial light at night may contribute to mood disturbances and sleep disorders and consequently affect alertness and …

An Edna Assessment Of The Diamond Darter (Crystallaria Cincotta) In Its Current And Historic Distribution Range, Cameron Moore Layne

Graduate Theses, Dissertations, and Problem Reports (ETD)

Environmental DNA (eDNA) can serve as a useful monitoring tool for cryptic and imperiled freshwater stream fishes. eDNA can fill knowledge gaps regarding species’ distribution, site abundance, and habitat usage. The last known stronghold of the Diamond Darter (Crystallaria cincotta) in the Elk River of West Virginia provides an excellent test case to examine the utility of this non-invasive method of surveying rare species. Diamond Darters are one of the most newly recognized freshwater fishes in North America and are among the most imperiled U.S. fishes, having been federally listed as endangered in 2013. The cryptic behavior and limitations of …

Longitudinal And Ensemble Modeling Of Beef Cattle Feed And Water Intakes, Nathan El Blake

Graduate Theses, Dissertations, and Problem Reports (ETD)

Beef cattle production remains a cornerstone of global food systems, providing highly bioavailable protein and essential micronutrients that are difficult to secure from plant-based foods alone. Yet this production is also resource-intensive, requiring substantial land, feed, and water inputs while contributing significantly to greenhouse gas emissions. Efficiency of dry matter intake (DMI) and water intake (WI) is central to both productivity and sustainability, but accurate measurement of these traits—particularly in grazing systems—remains a major limitation. National WI standards continue to rely on pen-level data collected in the 1950s, while most existing DMI prediction equations perform poorly when applied beyond the …

Non-Lethal Sampling Methods For Fish Health Assessments Using Smallmouth Bass Micropterus Dolomieu, Lindsey Nicole Hartzell

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the early 2000s, fish kills of different species, including smallmouth bass Micropterus dolomieu, were reported in areas of the Potomac River drainage, including the Shenandoah River in Virginia. Since the first reports of fish kills and lesions affecting smallmouth bass, they have continued to show signs of adverse health effects. Additionally, in some areas of the Potomac River drainage, population declines have occurred, and lethal sampling is discouraged. To develop a holistic, integrative approach to assess fish health, Smallmouth Bass were collected and sampled using non-lethal techniques at three sites within the Shenandoah River drainage, VA and one …

Dynamic Force Feedback Controller Improves Metrics Of Stepping In A Biomimetic Robot Leg, Isabella Mae Kudyba

Graduate Theses, Dissertations, and Problem Reports (ETD)

Force feedback is a type of robotic control where forces are measured, fed back into the control system, and actuation is adjusted to compensate for environmental forces, with the goal of quick and precise limb positioning in walking. Robots of today use single force sensors (e.g. pressure sensitive pads, load cells) per leg which are often bulky, expensive, and susceptible to crosstalk. Walking robots often employ model predictive controllers or policy controllers trained through reinforcement learning (RL) to actuate their limbs, but these methods are time and energy consuming. Biomimetic robots offer an alternative approach, investigating biological theories with the …

Ciliary Arl14b In Vision, Alexis Breann Crockett

Graduate Theses, Dissertations, and Problem Reports (ETD)

Primary cilia are highly specialized organelles that regulate signaling, trafficking, and sensory perception across multiple tissues, including the retina. The small GTPase ADP Ribosylation Factor-Like Protein 13B (ARL13B) is an atypical ARF-family protein enriched in cilia. ARL13B acts as a guanine exchange factor (GEF) for another small GTPase ARF-like Protein 3 (ARL3). Mutations in ARL13B cause Joubert syndrome, a ciliopathy characterized by brain malformation, developmental delays, and retinal degeneration. Despite ARL13B’s known ciliary localization and clinical relevance, ARL13B’s precise functions in cilia remain poorly defined. This dissertation investigates the cilia-specific roles and GEF-specific roles of ARL13B in photoreceptors using two …