Digital Commons Network^™

Multi-Attribute Characterization Of Polymeric And Lipid-Based Drug Delivery Systems By Column Switching Liquid Chromatography-Mass Spectrometry, Brady W. Drennan

Chemistry & Biochemistry Dissertations - Archive

Drug delivery systems (DDS) are an increasingly relevant technology, owing to their ability to provide controlled release and to enable the use of otherwise toxic or labile therapeutics. However, these modalities are complex, containing a multitude of species with diverse chemical and physical properties. Their characterization, which involves the assessment of critical quality attributes (CQAs), requires numerous analytical techniques. The high-throughput demands of the biopharmaceutical industry have driven the need to consolidate these characterizations into a single analytical method. Consequently, novel analytical technologies are needed to support multi-attribute characterization. A multimodal liquid chromatography–mass spectrometry (LC–MS) system was developed to facilitate …

The Ethical Impermissibility Of Implanting Embryos That Carry The Genetic Markers For Deafness, Cat Mastalerz

Journal of Health Ethics

Preimplantation genetic diagnosis is a reproductive procedure that involves testing embryos conceived by in vitro fertilization for genetic conditions, including cystic fibrosis, Duchenne’s muscular dystrophy, and controversially deafness. This paper examines the ethical dilemma surrounding parents using this technology to select for and choose to implant an embryo that carries the genetic markers for deafness. Disability and impairment are discussed, followed by an in-depth analysis of the role of Deaf culture, including the perspective of hearing children of deaf adults. The effect of deafness on life opportunities is then viewed through the lens of the child’s right to an open …

Characterization Of Cancer Cell Migration Through Brain Vascular Endothelium Model, Malak Taysser Al-Noubani

2025 Fall Honors Capstones Projects - Archive

One of the hallmarks of cancer is increased vessel growth to feed the tumor’s rapid expansion. The newly formed blood vessels are immature and often leaky due to structural and functional abnormalities. This leads to ineffective anti-cancer drug delivery and provides tumor cells with additional opportunities to metastasize. We propose to develop an in vitro vascular endothelium model and introduce aggressive triple-negative breast cancer (TNBC) cells to mimic the tumor environment, utilizing a Transwell migration assay. The impact of TNBC cells on vessel permeability will be assessed by staining for tight junction proteins, and the migratory capabilities of TNBC cells …

Cal Poly Humboldt Sea Level Rise Institute Bi-Annual Report June 2023 - June 2025, Adam Canter, Laurie Richmond, Kristen Orth-Gordinier

Local Reports and Publications

Executive Summary: As a core vision, the Cal Poly Humboldt Sea Level Rise Institute (SLRI) “envisions a diverse network of collaborators working together across disciplines, sectors, and ways of knowing to develop sea-level rise research and planning that informs equitable, sustainable, and community-centered local climate action.” The SLRI had two productive academic years from Fall 2023 - Spring 2025 in service of this vision. Key accomplishments included: ● Participation - Over the course of the past two years, participation in the SLRI more nearly doubled from 48 in August 2023 to 84 in July 2025. ○ Participation includes representatives from …

Dream Of Gangland: The Successful Life And Passing Of Jonny Torrio, Brantley K. Anderson

Tenor of Our Times

Johnny Torrio was one of the most interesting individuals to exist in the field of organized crime in Chicago. There were several factors that contributed to this fascination, not limited to the revenue he obtained through his illicit activities. He would be one of the only gang leaders to survive long enough to die of natural causes, an ending every mob boss would strive for. Historical records and accounts reveal that his mindset around crime, as well as his organizational strategy and interpersonal efforts, are, in part, reasons for his successful life and death. Comparison of other mob bosses of …

Tallgrass Prairie Center 2024-2025 Highlights, University Of Northern Iowa. Tallgrass Prairie Center.

Annual Reports

Contents:

--- Staff
--- From our Director
--- Iowa Roadside Management: Enhancing our public roadsides
--- Research and Restoration: Native seeds and methods for prairie reconstruction
--- Plant Materials: A prairie pedigree for Iowa’s roadsides and beyond
--- Irvine Prairie: Restoring a piece of the original Iowa landscape
--- Prairie on Farms: Making prairie practical
--- Prairie Roots Project: A deeper appreciation of the prairie ecosystem
--- Green Iowa AmeriCorps: Service members expand TPC capacity
--- A Hidden Gem - UNI's Biological Preserves: A legacy of service and partnership
--- UNI Students at the TPC: Practical experience in support of …

Non-Enzymatic Glycoxidation Reports On Society, Environment And Biology To Inform On Enduring Cancer Disparities, Fariha Imtiaz, Boxiao Ding, Bradley A. Krisanits, Katherine A. Walter, Lindsay L. Peterson, Susan Steck, Marvella E. Ford, Gayenell Magwood, Victoria J. Findlay, David Turner

Annual Research Day

Background: Despite advancements in cancer treatment, disparities in incidence and mortality persist among different races and ethnicities. These disparities are influenced by an intricate interplay between environmental, biological and social factors that underscore the need for a multifaceted approach to understand this relationship. Objective/Aim: To show that advanced glycation end products (AGEs) due to non-enzymatic glycoxidation represent informative and functional markers that report on the combined impact of environmental, biological and social factors on enduring cancer disparities. Methods: To address this objective, a more holistic approach to disparities research was used ranging from basic research, population-based investigations, preclinical and clinical …

Annual Report 2023-2024: Student Life & Development, Denise Mcdowell

Annual Reports

Student Life and Development (SLD) professionals at Winona State University (WSU) deliver programs, services, and activities that support students' academic achievement, social development, and well-being in the timely pursuit of their educational goals. The 2023-2024 SLD Annual Report provides information from the following departments: Admissions, Community Engagement, Conduct & Citizenship, Counseling and Wellness Services, Dean of Students, Equity & Inclusion Excellence, Health & Wellness Services, Housing & Residence Life, Integrative Wellness, Student Union & Activities, TRIO Student Support Services, the Warrior Hub, and the Warrior Success Center.

Two-Year Biomass And Productivity Data For Populus Trials In Mississippi, Courtney M. Siegert, Heidi Renninger, Austin Himes, Waqar Shafqat, Andrea Drager

CFR Publications

This dataset contains two years of biomass and productivity data for field trials of Populus in Mississippi.

The Collaborative Care Model And Depression Mediation Adherence, Remmy Rocha, Megan Mcclain, Anusha Mubin, Nicholas Morgenstern, Makenzie Maroney, Melanie Menning, Shannon Kinnan, Ryan W. Walters

Posters and Presentations: Family Medicine

No abstract provided.

Awake And Affected: Cultural And Socioeconomic Impacts On Sleep Insufficiency In Modern-Day Ohio, Nehal Mittal, Marina Shenouda

Scholarship in Medicine - All Papers

Background: Previous literature explores factors such as urban environments, screen use and stress negatively impact sleep quality in American adults. However, there is a lack of demographic focus on non-white, low-income populations specifically related to sleep. There is a growing need for targeted interventions to address increasingly prevalent disparities.
Objective: Our study aims to look deeper into race, age, and socioeconomic status and other demographic factors that may affect sleep health.
Results: Our analysis revealed a strong positive correlation between insufficient sleep and selfreported poor or fair health (r = .728) and a moderate positive correlation with unemployment (r = …

Legal Practice Practicums: Making A Case For Change: A Way Forward, John O. Sonsteng, Michael Sonsteng, Kenneth Rubenzer

Faculty Scholarship

No abstract provided.

An Interdisciplinary Fetal Neonatal Neurology Collaborative Promotes Integrative Life-Course Brain Health., Mark S Scher, Harris Eyre, Steven Donn, James M Roberts, Michael E Msall, Carolyn M Salafia, Richard Towbin, Peter N Robinson, Ken Loparo, Michael Berk, Elena Moro, Valerie Smith, Susan Ludington, Nadia Badawi, Rod W Hunt, Alistair Gunn, Harvey B Sarnat, Kirthana Kunikullaya, Betsy Pilon

Faculty Research 2026

A proposed interdisciplinary fetal neonatal neurology collaborative offers life-course brain health training across three time-sensitive teaching opportunities. The educational organization includes a broad representation of inter-related fields. Formal training will re-enforce career-long learning that fosters creative thinking. Acquiring a life-course perspective of brain health can contribute solutions to the global public health crisis involving neurological and mental health disorders across the lifespan. Teaching transdisciplinary interventions begins with parental childhood and reproductive health which will influence the maternal-placental-fetal triad throughout pregnancy into labor and delivery. The second teaching opportunity focuses on the symptomatic minority who receive neonatal neurocritical care and convalescent …

Topo-Vm-Unetv2: Encoding Topology Into Vision Mamba Unet For Polyp Segmentation, Diego Adame, Jose Angel Nunez, Fabian Vazquez Jr., Nayeli Gurrola, Huimin Li, Haoteng Tang

Computer Science Faculty Publications

Convolutional neural network (CNN) and Transformer-based architectures are two dominant deep learning models for polyp segmentation. However, CNNs have limited capability for modeling long-range dependencies, while Transformers incur quadratic computational complexity. Recently, State Space Models such as Mamba have been recognized as a promising approach for polyp segmentation because they not only model long-range interactions effectively but also maintain linear computational complexity. However, Mamba-based architectures still struggle to capture topological features (e.g., connected components, loops, voids), leading to inaccurate boundary delineation and polyp segmentation. To address these limitations, we propose a new approach called Topo-VM-UNetV2, which encodes topological features into …

Positive Reinforcement In Leadership, Jen Lee Williams

M.S. in Leadership

This project examined whether leaders’ use of positive reinforcement
improves team retention, satisfaction, and performance across Generation
X, Millennials, and Generation Z. Jen Williams selected this topic due to the
rising turnover challenges and lack of consistent reinforcement training in
leadership practice. Using mixed-methods design, the study combined a
quantitative survey of 13 working professionals with a qualitative interview
from a Generation X leader participant. Results showed that over 92% of
the participants felt motivated by recognition, and 72% linked
reinforcement to increased satisfaction and desire to stay with their
organization. Generational differences appeared in frequency, authenticity,
and emotional sensitivity …

Structural And Functional Changes In The Hippocampus Induced By Environmental Exposures, Emad A. Albadawi

Neurosciences

ABSTRACT The hippocampus, noted as (HC), plays a crucial role in the processes of learning, memory formation, and spatial navigation. Recent research reveals that this brain region can undergo structural and functional changes due to environmental exposures, including stress, noise pollution, sleep deprivation, and microgravity. This review synthesizes findings from animal and human studies, emphasizing the HC’s plasticity in response to these factors. It examines changes in volume, architecture, neurogenesis, synaptic plasticity, and gene expression and highlights critical periods of vulnerability to environmental influences impacting cognition and behavior. It also investigates underlying mechanisms such as glucocorticoid signaling, epigenetic alterations, and …

Local-Neutrosophic Logic And Local-Neutrosophic Sets: Incorporating Locality With Applications, Florentin Smarandache, Takaaki Fujita

Branch Mathematics and Statistics Faculty and Staff Publications

The study of uncertainty has been a significant area of research, with concepts such as fuzzy sets [87], fuzzy graphs [51], and neutrosophic sets [58] receiving extensive attention. In Neutrosophic Logic, indeterminacy often arises from real-world complexities. This paper explores the concept of locality as a key factor in determining indeterminacy, building upon the framework introduced by F. Smarandache in [73]. Locality refers to processes constrained within a specific region, where an object or system is directly influenced by its immediate surroundings. In contrast, nonlocality involves effects that transcend spatial or temporal boundaries, where changes in one location have direct …

Biol 375-002: Conservation Biology, Michael Nelson

Biology Syllabi

No abstract provided.

Biol 628-002: Cell Biology Of Disease, Darshan Desai

Biology Syllabi

No abstract provided.

A Profile Of Sophomore Inquiry Students Fall 2025, Rowanna L. Carpenter

University Studies Assessment Research

In order to better understand the students who enroll in Sophomore Inquiry (SINQ) courses and begin to identify areas where they may need support, University Studies (UNST) began collecting and compiling data on these students. This report presents a profile of SINQ students from Fall 2025. It presents an overview of all students enrolled in SINQ during Fall 2025 and then summarizes information from the Prior Learning Survey. It is organized around three areas that contribute to student success: academic preparation and concern; financial and physical wellbeing; and connectedness to campus.

A Profile Of Freshman Inquiry Students Fall 2025, Rowanna L. Carpenter

University Studies Assessment Research

In order to better understand the students enrolled in Freshman Inquiry (FRINQ) courses and identify areas where they may need support, University Studies (UNST) began collecting and compiling data on these students. This report presents a profile of FRINQ students from Fall 2025. It presents an overview of all students enrolled in FRINQ during Fall 2025 and then summarizes information from the Prior Learning Survey.

2024-2025 Georgia Southern University Women's Rifle Statistics, Georgia Southern University

Women's Rifle Records

No abstract provided.

2024-2025 Georgia Southern University Women's Rifle Roster, Georgia Southern University

Women's Rifle Records

No abstract provided.

An Interdisciplinary Unit For Today's Learners: Integrating Science, English, And Art To Teach Climate Change, Sydney M. Ruby-Pasternak

Graduate Student Theses, Dissertations, & Professional Papers

As today’s global challenges grow increasingly complex, interdisciplinary thinking is essential for students to make meaningful connections in their learning. Despite this need, high school students continue to have educational experiences in one-subject classrooms, often preventing them from engaging in integrated learning models. This professional project addresses the gap by developing a five-week interdisciplinary unit titled Brushstrokes of Change, which combines climate science with English language arts and visual arts to amplify student understanding of climate change concepts. This unit was designed for grades 9-12 and prioritizes 21^st-Century skills in critical thinking, communication, creativity, and collaboration through …

Scrutinizing Sex, Jessica A. Clarke

University of Chicago Law Review

Critics of the Supreme Court’s equal protection jurisprudence despair that the Court conceives of discrimination as the mere classification of individuals on for- bidden grounds, such as race and sex, rather than systemic patterns of subordination. On the Court’s anticlassification theory, affirmative action, which relies on overt racial or gender classifications, is generally forbidden. Anticlassification rules are insensitive to context: a classification is a classification, no matter how well intentioned it might be, no matter what effects it might have, and no matter if it treats members of various groups in ways that are substantively equal. Whether a classification might …

Visitation As Family Regulation, Laura Matthews-Jolly

North Carolina Law Review

No abstract provided.

Dead In The Water: A Critique Of The Fourth Circuit’S Major Questions Analysis In North Carolina Coastal Fisheries Reform Group V. Capt. Gaston Llc, Dylan T. Silver

North Carolina Law Review

No abstract provided.

Are Blow Flies (Diptera: Calliphoridae) Active Nocturnally In South Georgia?, Breana R. Manning

Honors College Theses

Medicolegal forensic entomology uses insect colonization of remains to estimate minimum post-mortem intervals (mPMI). Blow flies (Diptera: Calliphoridae) are among the earliest colonizers, yet their nocturnal activity remains poorly understood. This study aimed to determine whether blow flies are active at night and whether artificial light influences their behavior. Using baited bottle traps in both artificially lit and unlit environments near Georgia Southern University, flies were collected over two trials in fall 2024. Of the 1,843 blow flies collected, only six were captured at night (0.003%), suggesting minimal nocturnal activity. Lucilia coeruleiviridis preferred unlit environments. In contrast, Cochliomyia macellaria was …

The Role Of Horizontal Gene Transfer In Antibiotic Resistance Amidst Prevalent Community And Healthcare-Associated Mrsa Rates, Gabrielle Nascimento

Honors College Theses

In recent decades, cases of community-acquired MRSA (CA-MRSA) and healthcare-associated MRSA (HA-MRSA) have been on the rise. The ability of antibiotic resistance to transfer between microorganisms greatly expands its threat to the effective treatment and containment of bacterial infections. The mecA gene is found on a mobile cassette within the Staphylococcal cell and encodes for PBP2a, an alternate version of penicillin-binding protein (PBP) with less binding affinity for β-lactam antibiotics, increasing resistance to the effects of antibiotics. The goal of this research is to investigate the horizontal transfer of the mecA gene between various Staphylococcus species as well as to …

The Effects Of A River Closure On A Snook (Centropomus Spp.) Nursery Community In The Rio Grande River, Texas, Ethan Getz, Perry Trial, Catherine Eckert, Joel Anderson

Gulf and Caribbean Research

Snook (Centropomus spp.) support important fisheries in the Gulf of Mexico and populations are increasing in Texas. However, a primary snook nursery, the Rio Grande River, remains one of the most imperiled rivers in North America. In 2001—2002, low flows led to the formation of a sandbar and the complete blockage of the Rio Grande, eliminating exchange with coastal waters. Here, data collected by the Texas Parks and Wildlife Department were used to determine how the Rio Grande closure affected juvenile and subadult snook and the estuarine community. Seine and trawl samples were collected prior to (1992—1997) and during …