Digital Commons Network^™

Quantitative Preventive Approaches To Diabetes: Mathematical Modeling And Analysis, Rushi P. Bhatt

Theses, Dissertations and Culminating Projects

The rising prevalence of diabetes presents a pressing global health concern, necessitating effective control strategies. This study aims to construct a mathematical model to analyze the influence of diverse factors on blood sugar levels, with a focus on identifying optimal methods for maintaining healthy glucose levels. Employing ordinary differential equations (ODE), the model investigates variables including leptin resistance, fat mass, glucose, insulin resistance, beta cell mass, daily physical activity, and dietary intake. Utilizing parameter estimates from existing literature, the model’s framework is established, and simulation results elucidate the intricate interplay between lifestyle choices and blood glucose dynamics. Furthermore, the model …

Interpretable And Data-Driven Machine Learning Models For Analyzing High-Dimensional Biological Data, Junchen Yang

Yale Graduate School of Arts and Sciences Dissertations

High-dimensional biological data, including single-cell omics, are prevalent in modern biology for characterizing a wide range of biological processes and phenomena. Although our capacity to generate such data has expanded at an unprecedented pace, significant challenges remain in extracting the informative features and the underlying biological signals. In particular, these datasets not only exhibit high dimensionality but also suffer from issues including inherent noise, low signal-to-noise ratio, and intrinsic heterogeneity. While machine learning models hold great promise for analyzing such data, their complexity and sensitivity to data characteristics often impede biological interpretability. To address these interconnected challenges, this thesis develops …

Integrated Roadside Vegetation Management Technical Manual [2025], Kristine Nemec, Josh Brandt, Kirk Henderson, Jim Uthe

Faculty Book Gallery

The objective of this publication is to provide basic technical support for new and existing Iowa county roadside programs. This manual is also intended to provide guidance to policymakers and engineers interested in adopting or expanding integrated roadside vegetation management in county rights-of-way.

Climate Change And Corporate Law In The United States: Not "Woke" But Eyes Open., Cynthia A. Williams

Articles by Maurer Faculty

This Essay discusses the evidence that climate change and nature loss create financially material risks for corporations that must be carefully considered by officers and directors pursuant to their fiduciary duties of loyalty and care. This analysis concludes that under the current state of fiduciary duty law and the known financial risks presented by climate change and nature loss, officers and directors of corporations may breach their fiduciary duties by failing to implement and monitor a robust system to identify and manage each type of industry-specific climate-related and nature related risk. Risk of breach is particularly acute for entity-specific compliance …

Aberrant Splicing Exonizes C9orf72 Repeat Expansion In Als/Ftd, Suzhou Yang

Yale Graduate School of Arts and Sciences Dissertations

A nucleotide repeat expansion (NRE) (GGGGCC)n in the first annotated intron of the C9ORF72 (C9) gene is a common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). While previous studies have shown that C9 NRE produces several toxic dipeptide repeat (DPR) proteins, how an intronic RNA segment can access the cytoplasmic translation machinery remains unclear.

By capturing and sequencing NRE-containing RNAs from patient-derived fibroblasts and neurons, I found that C9 NRE became part of an alternatively spliced exon 1 through the usage of various downstream 5ʹ splice sites. These NRE-containing splice isoforms accumulate in C9 ALS/FTD brains, …

D-Dimer As A Bio-Marker For Assessment Of Disease Activity In Rheumatoid Arthritis Patients, Ahmed Othman, Amir A. Youssef, Y. Tera, Yasmin Adel

Mansoura Medical Journal

Background Rheumatoid arthritis (RA) is considered the most common inflammatory joint disorder. It can lead to early morbidity, mortality and increased incidence of functional disability. Achieving rapid remission in early disease appears to be a beneficial strategy in preventing work disability in RA patients. The lack of specificity of commonly used inflammatory markers prompted the investigation of novel ones for estimating disease activity in RA. D-dimer has been one of these new markers, as RA is known to induce a hypercoagulable state. Aim This study aimed to investigate the possibility of utilizing D-dimer as a potential marker for assessing RA …

Fiddler Crabs (Crustacea: Decapoda: Ocypodidae) From Coastal Ecuador And The Galápagos Islands: Species Descriptions And Dna Barcodes, Carl L. Thurman, John C. Mcnamara, Hsi-Te Shih, Mariana V. Capparelli

Faculty Publications

Neotropical regions near the equator are recognized as speciation “hot spots” reflecting their abundant biodiversity. In western South America, the coasts of Panama, Colombia, Ecuador, the Galápagos Archipelago, and northern Peru form the Tropical Eastern Pacific biome. This area has the greatest heterogeneity of sympatric fiddler crab species of any portion of the planet. Since the coastal fauna has not been assessed for almost 50 years, we studied fiddler crab species diversity in Ecuador and on the Galápagos Archipelago. Preserved collecting records for various species were examined at the U.S. National Museum of Natural History, Washington, DC, the American Museum …

Sonic Photovoice And Critical Literacy: Listening To And Sounding What Is Me, What Is Not Me, And What Is Between, Alexander Chadwell

Theses and Dissertations--Curriculum and Instruction

This study examined sonic photovoice, a sound-based arts research method, as a tool for developing critical literacy in middle and high school students. Participants found and recorded sounds related to three categories, “what is me,” “what is not me,” and “what is between,” composed a sound collage using the sounds, and reflected on the experience. Framed by 4EA cognition, participatory sensemaking, and relational and everyday aesthetics, the study explored how listening and sounding shaped students’ conceptions of self and reality. Data from recordings, journals, and interviews suggest that the sonic engagement can foster relational, emergent understandings of self and …

Full Ride To College, But At What Cost?: Colonial Subjects At Imperial Educational Institutions In Binti And The Fifth Season, Martha Zornow

English Faculty Publications

A marginalized young person, often of a different physiognomy from those wielding power, sees the 'ivory tower' in her universe as a path to the learning, respect, power, and agency not available to her in her home environs. At their educational institutions, while their Blackness is not the basis for their outsider status, the Othering they experience mirrors that experienced by Black students at predominantly white universities in the real world. Theorizing the Colonial Role of Educational Institutions Following Thomas Macaulay's notorious' Minute on Education'(1835), educational systems have played a vital role in reaffirming the balance of power between the …

Person-Centered Pluralism About Contract Theory, C. Scott Pryor

Scholarly Works

No abstract provided.

Ce 432 Syllabus: Stress Management, Amy Andersen

Counselor Education Syllabi

This course will provide an introduction to important concepts, issues, skills, and interventions related to the identification and management of personal stress.

In Vitro Evaluation Of Retention Of Double-Crown Prostheses Connecting Natural Teeth And Implants. A Comparative Analysis Of Zirconia, Pekk, And Cobalt Chromium Materials For Primary And Secondary Crowns, Sarah Zaman Sahib Awad, Khloud Ezzat Mourad, Ahmed Sameh Abdelaziz Ismail, Aisha Zakaria Hashem Mostafa

Mansoura Journal of Dentistry

Purpose Objective: To assess and compare the retention performance of different material combinations—Zirconia, PEKK, and Cobalt-Chromium—over time using insertionremoval tests simulating one year of use. Materials and Methods: Nine mandibular polyurethane models with two canines and two dummy implants (first molar area) were used. Three groups of double-crown prostheses were fabricated, differing in materials used for both primary and secondary crowns: Zirconia, PEKK, and Cobalt-Chromium. All crowns were CAD/CAM-designed. Retention was tested using a Universal Testing Machine, with each overdenture subjected to 1,440 insertionremoval cycles to simulate one year. Final retention forces were measured and analyzed using SPSS v23, with …

Mandibular Chondrosarcoma: A Rare Case Report, Moataz Elhefny, Islam Hamada, Ahmed Khalil

Mansoura Journal of Dentistry

Purpose: Chondrosarcoma is a malignant tumor of cartilaginous tissue. It is more apparent in the axial skeletal bone but rare in the head and neck region. The biopsy is the definite way to diagnose Chondrosarcoma and surgical dissection is the direct way of management. Case description: A 76 years old male patient diagnosed with Chondrosarcoma in the mandible at the the premolar region after a history of a non-specific sclerosing osteomyeiltis at the same region 7 months ago. It was a low-grade form with good prognosis. Conclusions: Chondrosarcoma is malignant neoplasm of cartilaginous tissue. It is rare in the oral …

Effect Of Different Implant Designs On Primary Stability In Different Substrates, Mohamed Adel Ebrahim, Ahmad Mostafa Hussein, Mohamed Abdelmonem Tawfik, Elsayed Gad Eid

Mansoura Journal of Dentistry

Objective To clarify whether implant macrodesign has any influence on primary stability. Implant primary stability was evaluated in different substrates (fresh cow ribs and polyurethane artificial bone blocks) using several methods. Materials and Methods A total of 36 titanium dental implants (3.5 mm × 10 mm) and then divided into 3 groups (n=12): implants have trapezoidal thread design, implants have buttress thread design and implants have reverse buttress thread design were inserted in two different substrates (six fresh cow ribs and eighteen polyurethane casts). Immediately after insertion of dental implant, the implant stability was measured using three different methods (insertion …

Fracture Resistance Of Different Lithium Disilicate Restorations After Endodontic Access Cavity Preparation: Effect Of Repair Method, Hebah Agamal Abdulghafor, Essam A. Khedr, Nesma M. Elgohary, Walid A. Al-Zordk

Mansoura Journal of Dentistry

Objective: To evaluate the effect of different repair methods on the fracture resistance of lithium disilicate restorations after endodontic access cavity preparation. Materials and Methods: One hundred sixty sound human mandibular first molars were prepared and restored with four types of lithium disilicate–based crowns: IPS e.max CAD, GC Initial LiSi Block, Straumann n!ce, and CEREC Tessera (n = 40 each). Standardized endodontic access cavities were prepared in all specimens, then repaired using one of four techniques: (1) inlay restoration with Monobond Etch&Prime, (2) inlay restoration with IPS Ceramic Etching Gel + Monobond Plus, (3) direct composite with IPS Ceramic Etching …

2025-2026 Lynn University Academic Catalog, Lynn University

Academic Catalogs

The 2025-2026 Academic Catalog initially published as a web-only document.

This is a PDF version, created by the Department of Marketing and Communication.

(Updated Dec. 11, 2025.)

Social Determinants Of Health And Health Confidence: A Cross-Sectional Study, Laura Truman, Patricia Calero, Caroline Etland, Razel Bacuetes Milo, Cynthia D. Connelly

School of Nursing and Health Science: Faculty Scholarship

No abstract provided.

Zinc Or Swim: Investigating Zinc Pollution From Restoration Materials, Megan R. Jensik

Honors Undergraduate Theses

Zinc is an essential nutrient, but can be toxic at high concentrations, negatively affecting various biological functions. Gabions are galvanized metals coated in zinc that are used for many human purposes, including coastal restoration efforts attempting to avoid using plastic materials. However, gabions can degrade in marine environments, potentially leaching metal into the water and soil. There is a knowledge gap regarding the occurrence and impacts of zinc pollution in the areas where these gabions are deployed, including the Indian River Lagoon (IRL). To address this, sediment samples were collected from the IRL and analyzed for their physical and chemical …

Comparing Interactive Versus Static Educational Images On Student Learning Outcomes, Noah Schwartz

Honors Undergraduate Theses

Static images routinely accompany text in educational sources such as textbooks, articles, and websites to convey complex, educational information. These are generally effective; however, current technology allows for interactive images that seem to enhance engagement. How effective are these interactive images? The present study investigated whether an interactive image produced better learning outcomes compared to a static image using the same text. Specifically, this study examined whether interactive images affected comprehension, memory, engagement, and cognitive load differently than static images. In this study, data from 153 college student participants were analyzed. First, participants were assigned to read about the neuropsychology …

Regulation Of Human Dna Mismatch Repair, Breanna Knicely

Theses and Dissertations--Toxicology and Cancer Biology

The DNA mismatch repair (MMR) pathway identifies and corrects misincorporations that arise during DNA replication. MMR is a pathway that is critical for maintaining genomic stability. Mutations within the MMR pathway, both germline and somatic, lead to the development of cancer. There are a variety of mechanisms that regulate the MMR pathway including protein-protein interactions, DNA damage response, and post-translational modifications. In this study, we aim to dive deeper into each of these mechanisms to obtain novel information regarding the mechanisms and regulation of human DNA MMR. In this study we generated hExo1 constructs mutating Exo1’s interactions with MSH2 and …

2024 Annual Survey: Recent Developments In Sports Law, Joseph A. Delia, Sydney A. Hardy

Marquette Sports Law Review

No abstract provided.

Archival Facilities Specifications, Archives Development Program

Tennessee Archives Management Advisories

No abstract provided.

The Paradox Of Survival: Gendered Food Insecurity, Labor Inequalities, And Coping Strategies During The 2023/4 Drought In Eastern Ethiopia, Meron E. Lemma

Theses and Dissertations--Geography

In drought-prone regions of Eastern Ethiopia, recurring droughts profoundly reshape everyday life in ways that deepen existing gendered inequalities. Drawing on fieldwork conducted in Fedis district, including semi-structured interviews with women, project implementers, and government officials, as well as group discussions with community members, this study explores how women experience, navigate, and resist the gendered impacts of drought. By attending to the sociopolitical dynamics of drought and the development interventions that accompany it, I analyze how these forces restructure labor, land, food systems, and authority in ways that reproduce and exacerbate existing inequalities. Women’s coping strategies, ranging from begging and …

Commercial Attention Spaces: A Century Of Discourses, Measurements, And Models Of Attention In The Construction Of U.S. Advertising Markets, Jacob Saindon

Theses and Dissertations--Geography

A vast assemblage of networked devices populate our everyday spaces. Concomitant with the increasing ubiquity of media devices are advertisements. Indeed, many networked devices, specifically the “free-to-use” software applications, websites, or platforms displayed through them, are advertising-dependent. An assortment of firms within the commercial media industry—brands, agencies, publishers, vendors—work in concert to sustain a market for advertising. The core operation of the commercial media industry, I argue, is the production and exchange of attention as an economic object. In this study, I approach the production of attention and the framing of its markets as spatial processes. The continued growth of …

Effect Of Pulsed Electromagnetic Field Therapy On Milk Quality In Organic Dairy Cows, Kayla A. Young

Honors Theses and Capstones

Organic dairy systems are limited when it comes to the use of antibiotics and pharmaceuticals which creates opportunities to explore alternative treatments to promote cow health. Pulsed electromagnetic field therapy (PEMF), a form of electromagnetic stimulation, promotes various types of healing for both animal and human medicine. Our objective was to explore the effect of PEMF on milk yield and composition in organic dairy cows. Mid-lactation Jersey cows (n = 35) of various parities were randomly assigned to 1 of 3 treatments: 1) control (CON; n = 12); no PEMF, 2) once daily PEMF (PEMF1; n = 12), …

Tryptophan Kynurenine Pathway-Based Imaging Agents For Brain Disorders And Oncology-From Bench To Bedside, Erik Stauff, Wenqi Xu, Heidi H. Kecskemethy, Sigrid A. Langhans, Vinay V. R. Kandula, Lauren W. Averill, Xuyi Yue

Jefferson Hospital Staff Papers and Presentations

Tryptophan (Trp)-based radiotracers have excellent potential for imaging many different types of brain pathology because of their involvement with both the serotonergic and kynurenine (KYN) pathways. However, radiotracers specific to the kynurenine metabolism pathway are limited. In addition, historically Trp-based radiopharmaceuticals were synthesized with the short-lived isotope carbon-11. A newer generation of Trp-based imaging agents using the longer half-lived and commercially available isotopes, such as fluorine-18 and iodine-124, are being developed. The newly developed amino acid-based tracers have been demonstrated to have favorable radiochemical and imaging characteristics in pre-clinical studies. However, many barriers still exist in the clinical translation of …

Movement Public Health: Addressing The Links Between Public Health And Carceral Systems, Marie Fatima Hyacinthe

Yale Graduate School of Arts and Sciences Dissertations

This dissertation is an interdisciplinary exploration of the links between public health and carceral systems, the connections between academic scholarship and advocacy, and the role of public health research in social justice movements. This dissertation begins with in-depth interviews with academic researchers and anti-carceral organizers, as well as analyses of my own experiences taking part in protests and mutual aid work, which ground conversations on the meaning of safety and care, and the role of public health. The second chapter is a systematic literature review and synthesis where I analyze academic literature about public health and carceral systems, assessing it …

Dynamical Mechanisms Of Neural Computation, Frederick Michael Berl

Yale Graduate School of Arts and Sciences Dissertations

The brain is one of the most complex dynamical systems in the universe and despite our everyday familiarity with it, the intricacies of how it functions remain a mystery to us. It is enormously powerful, continuously learning, and able to perform computations flexibly and adapt to novel situations. Although science presently has an understanding of how individual neurons work and a general idea of what the functions of each region in the brain are, how the computations of each neuron are modulated by context and how the various regions work together to produce behavior are unclear. Here, we explore the …

A Possible Mechanism Of Miwi2-Mediated Dna Methylation By De Novo Dna Methyltransferases, Tianshu Liu

Yale Graduate School of Arts and Sciences Dissertations

Epigenetic information refers to inheritable information that is not directly encoded in the genomic locus. Among various epigenetic mechanisms, DNA methylation play a crucial role in development and homeostasis and undergoes dynamic remodeling during mouse embryogenesis. In the mouse germline, primordial germ cells experience a global erasure of DNA methylation, a process important for the re-establishment of parent-specific methyl-imprint in the late stage of gametogenesis. However, how DNA methylation occurs at specific genomic loci remains an open question. Miwi2, one of three murine PIWI proteins, has been implicated in guiding de novo DNA methylation, yet the molecular machinery of Miwi2-mediated …

The Gnda Microprotein Supports Atp Homeostasis In Escherichia Coli During Heat Shock, Jessica Jayne Mohsen

Yale Graduate School of Arts and Sciences Dissertations

Same-strand overlapping, or nested, open reading frames (ORFs) can optimize the information content of size-constrained viral genomes by increasing the number of proteins expressed from a limited nucleotide sequence. However, nested small open reading frames (sORFs) were previously omitted from prokaryotic and eukaryotic genome annotations. It was therefore surprising when numerous nested sORFs were recently discovered in bacteria and eukaryotes. Our case study of the GndA microprotein in Escherichia coli provides evidence of an emerging model that overlapping genes can be expressed from bacterial genomes to contribute to cellular fitness. GndA interacts with the electron transport chain and ATP synthase …