Digital Commons Network^™

Kentucky Comfort Care: Understanding And Awareness Of Palliative And Hospice Care In Kentucky Adults, Riley E. Hicks

Honors Theses

Kentucky has an overwhelming need for both palliative and hospice care services because of the high percentage of individuals who struggle with chronic or life-threatening conditions. Studies have shown that access to palliative and hospice care may be inhibited by the knowledge patients have of these services. The purpose of this study was to examine the awareness and understanding Kentuckians have of palliative and hospice care and to determine the factors influencing them. A 22-question survey was administered to collect information about Kentuckians understanding of available palliative and hospice care services and common vocabulary used by providers in these settings. …

Deep Learning Methods For Protein - Small Molecule Interactions With Applications To Early-Stage Drug Discovery, Gregory William Kyro

Yale Graduate School of Arts and Sciences Dissertations

Drug discovery is a challenging endeavor for multiple reasons including the complexity of protein-ligand interactions at the molecular-level, the vastness of chemical space, and safety constraints related to unintended biological effects. In this dissertation, I present a suite of novel deep learning approaches that address these challenges from multiple angles. I first introduce HAC-Net— a deep learning model that, at the time, was the state of the art for predicting protein-ligand binding affinity—which was used to identify a potential inhibitor of a G protein-coupled receptor whose overexpression leads to cancer, diabetes, and multiple sclerosis, as well as a potential antivirulence …

Long-Term English Learners: A Selected Annotated Bibliography For English Learner Research, Policy, And Practice, Center For Equity For English Learners

Annotated Bibliographies

Long-term English Learners: A Selected Annotated Bibliography for English Learner Research, Policy, and Practice is comprised of 25 annotations from recent and seminal literature regarding the education of students considered Long-term English Learners (LTELs), a subgroup of English Learners (ELs) who have not attained English language proficiency after six or more years. These annotations build on the annotations regarding LTELs in CEEL’s 2022 annotated bibliography, Ensuring Equity and Excellence for English Learners: An Annotated Bibliography for Research, Policy, and Practice (Center for Equity for English Learners, 2022) to include publications from 2022-2025. This selected annotated bibliography serves as a resource …

General Catalog 2025-2026, Utah State University

University Catalogs

This catalog contains information on the Academic Departments and Programs as well as Course Descriptions for the above school year at Utah State University.

Synthesis, Characterization, And Biological Activity Of Ni(Ii) And Co(Iii) Thiosemicarbazone Complexes As Potential Anticancer Agents, Jack Martin

Pitzer Senior Theses

The mechanics by which Reactive Oxygen Species work is an area of great interest given ROS’s wide range of biological applications. From cell signaling and mitochondrial regulation to pathogenesis and tumor cell death, varying concentrations of ROS in a system can lead to a whole host of positive and negative effects. In a similar vein, thiosemicarbazones are known to be equally useful for their myriad of antibacterial, antifungal, antiviral, and antitumoral effects. They have been at the core of the pharmaceutical world or the better part of the last century. The purpose of this work is to synthesize, characterize and …

Verification Of Real-Time Smoke Simulations: A Case Study On Early Summer North American Wildfire Events, Daniel Bonilla

Pitzer Senior Theses

As wildfire intensity and frequency escalate in times of unprecedented climate change and severe droughts, it is important to enhance forecasting models that accurately and efficiently predict wildfire smoke movement. NOAA’s experimental Rapid-Refresh Forecasting System with Smoke and Dust (RRFS-SD) aims to improve upon the High-Resolution Rapid Refresh- Smoke (HRRR-Smoke), by extending the domain to include all of North America and incorporating new developments in physics and wildfire parameterizations. Our work explores the process of adding satellite Aerosol Optical Depth (AOD) data, through AERONET, as an additional method of verification of the RRFS-SD experimental model. Using a case study on …

Optimizing Decision-Making In A Cerebral Palsy Model Using Reinforcement Learning, Richard Ampah

Pitzer Senior Theses

This study presents an original interdisciplinary investigation into how reinforcement learning (RL) can model motor and cognitive defects and potentially improve motor and cognitive functions in individuals with cerebral palsy (CP), a non-progressive neurological disorder that impairs movement and adaptability. Integrating computational neuroscience and machine learning, the research applies policy gradient methods and Markov Decision Processes (MDPs) to simulate adaptive learning in agents with and without CP-related constraints.

The central aim is to compare the cumulative rewards of optimal policies, derived from value iteration, and human-like learning policies using the REINFORCE algorithm, both with and without the Bellman baseline. The …

The Chesapeake Pearl: A Proposal For An Environmental Public Art Installation, Samuel I. Reichard

Pitzer Senior Theses

In this thesis, I lay the foundation for an environmental art project along Chesapeake Bay. It includes an analysis of relevant literature and case studies, as well as a proposal for the project. The Chesapeake Pearl (working title) would be a 20-foot spherical aquarium that will visually display the water filtration capacity of eastern oysters and native seagrass, aiming to inspire curiosity around these organisms and the greater Chesapeake Bay ecosystem. The project exists at the intersection of environmental art and environmental education and seeks to promote learning and public engagement through visually demonstrating a scientific process, the water filtration …

Visions Of The Garden: Transforming The Former Claremont Golf Course Into The Coastal Sage Mosaic, Ella C. Kim

Pitzer Senior Theses

A thirty-three-acre parcel of land sits at the foothills of the San Gabriel Mountains at a vulnerable wildland-urban interface (WUI), raising key ecological concerns. This parcel, a former golf course, is the focused site for this conceptual landscape and restoration plan. The now-neglected site has no proposed plans for restoration or development yet holds significant potential for transformation. Stakeholders’ conflicting visions range from land preservation, ecological restoration, Indigenous land rights, commodification for revenue and development, and prioritizing the needs of the natural environment in coexistence with modern human enjoyment. The conceptual plan addresses these critical considerations in verbal and visual …

Gis Minor, Geology & Geography

Program Revisions/Additions

No abstract provided.

True Threats And The Neuroscience Of Fear, Paul E. Mcgreal

Case Western Reserve Law Review

No abstract provided.

Disputing Death: Medical Futility Laws And Procedures To Facilitate End Of Life Discussions Among Patients, Family, And Practitioners, Emily Greco

South Dakota Law Review

In a world of continuous innovation, medical care in particular has changed the way humans experience life and death—lengthening life and slowing death. But where patients have the opportunity to be kept alive with medical intervention, physicians often struggle ethically with administering care that is ultimately futile or medically inappropriate. Many times patients themselves are unable to communicate, incapacitated by their ailment. As a result, surrogates must step in to make decisions on patients’ behalves. Surrogates, acting as advocates for patients, tend to withhold consent when a provider believes continued intervention is futile and wishes to withdraw or withhold treatment. …

Parent & Family Newsletter, March 2025, Illinois State University, Parent And Family Services

Parent & Family Newsletter

Parent and Family Newsletter

The Anatomy Of A Reconstruction: From Fourier Space To Image Recovery In Computed Tomography, Charlotte P. Maurer

Honors Theses

This thesis develops the mathematical foundations of computed tomography (CT) reconstruction through the lens of harmonic analysis. Beginning with the Schwartz class, we introduce the Fourier transform and its role in expressing the Radon transform and its inversion via a fractional Laplacian. After constructing the Radon transform in general dimension R^d, we specialize to the cases d = 2 and d = 3, demonstrating explicit inversion formulas and the associated instability in lower dimensions. For its computational advantages, we study filtered back-projection using classical low-pass filters (Ram-Lak, Shepp–Logan, Cosine, Gaussian) and formulate a discrete reconstruction algorithm grounded in …

Predicting Human Steering From Optic Flow Using Deep Convolutional Neural Networks, Katie E. Bernard

Honors Theses

Human driving is a complex visuomotor task and the specific visual clues that guide it remain under investigation. While prior research has emphasized gaze-based strategies such as the Tangent Point and Future Path hypotheses, recent evidence highlights the potential role of optic flow, the visual motion pattern perceived during self-movement, as critical to steering ability. This thesis explores whether raw optic flow alone can support accurate predictions of human steering behavior. We trained a convolutional neural network to map optic flow vector fields to steering angles in a virtual reality driving simulation. The dataset, collected by Giguere et al., included …

The International Transracial Adoption Effect: Measuring The Well-Being Of Korean Adoptees Vs. Non-Adopted Korean Americans, Grace H. Jones

Honors Theses

In this study, I examine the differences in well-being and long-term outcomes between adopted and non-adopted Korean Americans. The vast majority of adopted Korean Americans are placed with white, heterosexual couples, positioning them in a unique position in American society. While they are raised in white families and often disconnected from Korean culture, they are still perceived and treated as Asian by society. Scholars refer to this tension as the transracial adoptee paradox. This study explores how that paradox affects both economic and non-economic outcomes. The analysis finds that adopted Koreans tend to earn higher incomes than their non-adopted peers, …

Microbial Degradation Of Kelp-Derived Dissolved Organic Matter In The Context Of Carbon Sequestration, Sophia N. Riazi-Sekowski

Honors Theses

Kelp, or brown algae, is an emerging form of ocean-based biological carbon dioxide removal, converting dissolved CO2 into organic molecules via photosynthesis. The export of detritus and dissolved organic carbon (DOC) from coastal beds to beyond the continental shelf contributes to carbon sequestration, especially through the microbial production of refractory DOC (RDOC). The influence of microbial degradation on kelp-derived DOC is not yet well understood, contributing to inconsistency in carbon sequestration estimates. This study utilizes dark bottle incubations of both blades and holdfasts from two farmed kelp species in the Gulf of Maine — Saccharina latissima and Saccharina angustissima — …

The Value Of A Vote: Vote Pivotality Information And Its Impact On Voter Willingness To Accept, Nicholas J. Sickinger

Honors Theses

A variety of factors influence the decision to participate in a democratic election or not. This paper explores one of these factors: an individual’s perceived pivotality. I explore how people assess the value of their vote when they are informed about the likelihood that their vote will be pivotal. To do so, I conduct an online voting experiment where subjects participate in three different stylized elections: a marginal election, a landslide election, and an uninformed election (where the voter distribution is unclear to participants). I elicit participants’ vote valuations and compare them across election conditions and demographic groups using both …

Does The 25th Amendment Merit Reform?: The Challenge Of Determining Presidential Disability, Karena R. Andreassen

Honors Theses

This research project examines the persistent lack of use of the 25th Amendment to the United States Constitution in its original form, despite many calls for the reform of the language or expansion of its application as situations unfold. Adopted in 1967, the amendment was created to address the challenges of presidential succession and incapacity. However, historical events over the last few decades, such as the assassination attempt on Ronald Reagan, Reagan’s colon cancer, and the general increase in the age at which presidents assume office, have contributed to scrutiny over the amendments’ provisions. This study will explore why specifically …

Characterization Of A Highly Arsenic-Resistant Microbe, Eleanor E. Windholz

Honors Theses

Heavy metal pollution in our terrestrial and aquatic ecosystems is a major global concern, as chronic exposure to heavy metals such as arsenic and chromium has dire effects on mammalian health. In these polluted, arsenic-rich environments, microorganisms resistant to heavy metals have been isolated. The microbe isolated in this paper was resistant to As(V) up to 1100 mM, which is significantly higher than most published strains, and resistant to Cr(VI) at concentrations up to 5 mM. The microbe was tentatively identified as Micrococcus luteus, but its high arsenic resistance suggests it may be a novel strain. The ability of the …

Wave Reflections In A Biophysically Detailed Model Of Cardiac Tissue, Grace Moberg

Honors Theses

Regular heart rhythms are governed by the coordinated spread of action potentials through cardiac tissue. The interaction of an action potential with a tissue heterogeneity may lead to a reflection, where both a retrograde and an anterograde wave propagate off of the initial impulse. Reflections have been experimentally linked to cardiac arrhythmias, but their mechanisms of generation are not well-understood. Mathematically, reflections in phenomenological models of cardiac tissue have been linked to an unstable periodic orbit. These models typically sacrifice detail about the variety of ionic currents and processes involved in action potential propagation in favor of mathematical simplicity. Biophysically …

Introducing Catalizer: A Framework For Prototyping Models Of Biological Systems, Andy M. Day

Honors Theses

Modeling the light response system of Nannochloropsis oceanica brings

a set of challenges that make modeling difficult. Notably, potential models

may contain a large number of chemical species. A large number of

species creates a quadratic explosion in the number of potential pathways.

In addition, mathematically defining these pathways is error prone, yet

follows a surprising simple set of rules. We seek to create a domain specific

language which can precisely define these chemical reaction networks.

Once the networks have been defined, they can be exported as procedures

defined in popular programming languages for further analysis.

Asian American Navigation In Higher Education: Do We Belong At Colby College?, Amanda Rose Alpert

Honors Theses

This thesis explores how Asian American students navigate their belonging at Predominantly White Institutions (PWI), specifically a case study at the higher educational institution Colby College. In understanding how Asian American students navigate the spaces around them, this thesis dives into the history of Asian immigration to the U.S., the Asian American politicized label, and the different diasporas and cultural nuances Asian Americans experience that make up the complicated, diverse, and misunderstood label. Through exploring global racializations of Asian bodies and legacies of Western imperialism and colonialism, this gives a basis of how Asian Americans understand themselves as persons living …

Identifying The Spread Of Invasive Jumping Worms Across Maine’S Forests Using Soil Edna, Rebecca Wanger

Honors Theses

Jumping worms of the Megascolecidae family are invasive earthworms from East Asia that have been spreading across the United States since the late 1800s (Chang et al., 2021). Recently, the earthworms have gained more attention for their expansion into northeastern states, as they are believed to have negative impacts on the soil biogeochemistry, flora, and fauna of these forest ecosystems that have had no native earthworms given the recent nature of the Last Glacial Maximum (~11,000 yrs ago; Bohlen et al. 2004; McCay et al. 2020). The earthworms are distinguished by their thrashing behaviors, milky-white smooth clitellum, and evenly spaced …

Effects Of Direct And Indirect Predator Cue Intensity On Foraging Decisions In A Deer Mouse, Peromyscus, Nicholas G. Levinson

Honors Theses

Ecologists developed optimal foraging theory as a framework to understand how an animal may spend minimal time to maximize resource intake. A giving-up density (GUD) is a metric of the density of remaining food in a food patch at which an animal decides foraging is no longer economical. This study aims to test how the intensity of direct and indirect predator cues alter foraging patterns of deer mice. To measure GUD, I used depletable food patches deployed in the “upper woods” on the periphery of Colby College. To simulate direct predator cues, 1 mL of fox urine was applied on …

How Does Cocaine Exposure Affect Early Gene Expression Changes In The Prefrontal Cortex (Pfc) And Striatum?, Saathvika Diviti

Honors Theses

Cocaine use disorder (CUD) remains a significant public health concern, yet the molecular mechanisms underlying individual susceptibility are poorly understood. This study investigates early transcriptional responses to acute cocaine exposure in two key brain regions implicated in addiction, the prefrontal cortex (PFC) and striatum, using genetically diverse Diversity Outbred (DO) mice. Paired tissue samples were collected following a standardized sensitization protocol and analyzed via bulk RNA sequencing. Differential expression analysis revealed 37 significantly differentially expressed genes in the striatum. These genes overlapped with gene sets associated with substance use, neurodevelopmental disorders, and immune signaling, implicating shared pathways in central nervous …

Prophets Instead Of Priests: Diagonal Orientations & Coming-Of-Age Queerness In Jane Eyre And Oranges Are Not The Only Fruit, Emily G. Flanders

Honors Theses

This project asserts that the moment in which a girl leaves the trajectory of the expected in favor of the unknown in order to pursue her discovery of self is when her coming-of-age narrative becomes queer. This is demonstrated through Jane in Jane Eyre by Charlotte Brontë and Jeanette in Oranges Are Not the Only Fruit by Jeanette Winterson. Jane and Jeannette’s respective coming-of-age narratives–that is, them creating their fully embodied selves, the girl they believe and know themselves to be–happen off the expected life path in the liminal, in-between, undefined space of the queer oblique. There are moments …

Ai-Infused Discussion Boards: Enhancing Engagement, Reflection, And Academic Integrity In Anatomy And Physiology Education, Wade Dauberman

Teaching Repository of AI-Infused Learning

This paper presents the design, implementation, and evaluation of an AI-infused discussion board assignment that promotes ethical AI engagement, enhances student learning in anatomy and physiology, and addresses academic integrity concerns in higher education.

Space Agriculture, Biotechnology, And Terraforming: Rethinking The Paradigm Of Harmful Contamination, Francesca Giannoni-Crystal

Journal of Air Law and Commerce

As humanity transitions from sporadic exploratory space missions to permanent settlements on celestial bodies (like the Moon or Mars), agriculture biotechnology, and, potentially, terraforming projects will be essential for establishing self-sustaining settlements.

These activities raise critical issues concerning the interpretation of the principle of harmful contamination under Article IX of the Outer Space Treaty (OST) and its implementation through the Committee on Space Research’s Policy on Planetary Protection (COSPAR Policy) referred together in this article as the “Planetary Protection Framework,” which is primarily oriented toward exploration with scientific integrity rather than permanent habitation.

The challenge lies in the fact that …

Institutionalized Ostracism, Danieli Evans

Michigan Journal of Race and Law

Belonging is a fundamental need, like food or water. Hundreds of social psychology studies find that people who are ostracized (excluded, rejected, or ignored) experience severe pain and suffering. Ostracism threatens basic needs, triggers the same neurocognitive processing system as physical pain, and impairs functioning. Furthermore, ostracized people may cope in ways that beget “deviant” labeling and further ostracism.

Belonging and ostracism are prevalent themes in social psychology research, but these constructs have received relatively little attention in law. This Article begins to explore the implications of this research for law. I make three contributions: First, I name and describe …