Digital Commons Network^™

True Law As Genre: Narrative Nonfiction And The Law, Jorge L. Contreras

Texas A&M Journal of Property Law

The Genome Defense, which offers a book-length narrative nonfiction account of the civil litigation that led to the elimination of patents on human genes in the United States, is a member of a distinct literary subgenre that I term True Law. Like the older and better-known True Crime genre, True Law narratives blend the conventions of journalism and novelistic writing to describe complex legal disputes in a manner that is engaging and accessible to the general public. True Law accounts, which have increased in number and popularity since the publication of Jonathan Harr’s A Civil Action in 1995, serve …

Protecting Older Adults Who Are Incarcerated: Does The 8th Amendment Work?, Jalayne J. Arias

Health Matrix: The Journal of Law-Medicine

Older adults in prison and within other carceral systems (i.e. jails, parole) are uniquely at risk for elder mistreatment. Emerging research has begun to consider the experiences of older adults within carceral settings, including aging in prison, chronic conditions and medical care, compassionate release, and end-of-life care. This research exposes evidence that prisons and other carceral settings lack resources and services for older adults. Given increased vulnerability and a lack of protective resources, older adults experiencing incarceration may experience disproportional rates and consequences of elder mistreatment. A public health approach to develop tools and resources that would prevent, detect, and …

Body Size Distributions Of Riverine Freshwater Plankton Communities, Staci Ann Reynolds

Dissertations and Theses

The individual size distribution (ISD) is an individual based model that estimates the relative abundance of individual body sizes in a community. ISD’s slope or lambda (λ) gives insight into the communities’ food web and energy transfer. Climate change is expected to shift mean body sizes and λ as it increases individuals’ energy demands. Alterations in food webs and spatial distribution throughout the middle Missouri River basin may also have an impact on these communities λ. In a mesocosm experiment and field study, planktonic communities were sampled and had body sizes measured. Generalized linear mixed models were fit to calculate …

Undergraduate Curriculum Council Annual Report [2024-2025], East Tennessee State University

University Level Committee Year End Reports

No abstract provided.

The Unintended Consequences Of Normalization: Unmonitored Mental Health Discourse Among Youth And Suicide Risk, Farley Morris

Social Work Theses - Archive

Suicide has become an increasingly common cause of death among U.S. children ages 10–14. In 2001, suicide accounted for 8% of deaths in this age group; by 2010 the proportion rose to 12%, and by 2020 it reached 22% (Centers for Disease Control and Prevention [CDC], 2020). Although factors such as adverse childhood experiences (Felitti et al., 1998; Jones et al., 2024), psychache (Shneidman, 1998), burdensomeness (Joiner, 2005; O’Connor, 2011), and hopelessness (Bat Tonkus et al., 2022; Qiu et al., 2017) are associated with suicide, these elements alone do not explain the significant rise in suicide deaths over the past …

Social Drivers Of Suicide In Rural And Urban Texas Counties, Maria Y. Vaughan

Social Work Theses - Archive

Abstract

Suicide remains a critical public health issue in Texas, with rural counties consistently experiencing higher mortality rates than urban areas. This study examined county-level suicide rates across Texas and analyzed how demographic characteristics and Social Drivers of Suicide (SDoS)—including economic stability, education access and quality, health care access and quality, neighborhood and built environment, and social and community context—relate to suicide outcomes. Using a quantitative, descriptive, cross-sectional, and correlational design, secondary data from the 2024 County Health Rankings & Roadmaps and the American Community Survey were analyzed for 170 Texas counties with reliable suicide data. Results showed that rural …

Resilience And Reality: Exploring The Lived Experiences Of People Living With Hiv In Texas During The Covid-19 Pandemic – A Qualitative Study., Ahmed F. Alanazi

Social Work Dissertations - Archive

This study investigated the lived experiences of individuals living with HIV (PLWH) in the Dallas-Fort Worth (DFW) area of Texas during the COVID-19 pandemic, using an Interpretative Phenomenological Analysis (IPA) framework. The research examined the intersection of health, social dynamics, and psychological resilience among PLWH, who faced compounded vulnerabilities due to systemic inequities and the dual public health crises of HIV and COVID-19. Through semi-structured interviews with ten participants from diverse backgrounds, the study captured the profound impacts of disrupted healthcare systems, heightened stigma, and social isolation on this marginalized population. The findings reveal that the pandemic exacerbated existing inequities …

Unmet Family Planning Care And Health-Literacy Needs Among Low-Income Immigrant Women In The United States, Priyanjali Chakraborty

Social Work Dissertations - Archive

Unintended pregnancies have been linked to adverse outcomes such as pre-term births and low infant birthweight (Harron et al., 2020), psychological distress(Abbasi et al., 2013; Barton et al., 2017; Gauthreaux et al., 2017; Mercier et al., 2013), relationship strain (Barton et al., 2017; Moseson et al., 2019), intimate partner violence (IPV) and reproductive coercion (K. T. Grace & Anderson, 2018), and economic strain from unanticipated medical costs despite insurance coverage (Trussell, 2007). Unintended pregnancy outcomes offer crucial insights into the complexities of women's reproductive desires and intentions (CDC, 2023; Rossen et al., 2023). These outcomes inform public health interventions to …

Quantifying And Understanding The Role Of Bias In Astrophysical Data, Joshua A. Osborne

Physics Dissertations - Archive

Astrophysical studies are limited to the data provided. Data which is inherently prone to a range of biases such as: instrumental, selection, and methodological bias. Quantifying these biases and understanding their origin is critical to ensuring that the results we infer are representative of the physical world.

This is true even when attempting to study high-redshift phenomena, such as Gamma Ray Bursts (GRBs). Due to their immense brightness at high redshifts, GRBs serve as a strong candidate for standard candles in high redshift space. Their use as a standard candle, however, requires a precise understanding of observational biases that affect …

Investigating The Energetics And Feeding Ecology Of A Range Of Azhdarchid Pterosaurs, Kierra Miller, T. Alexander Deccechi

Annual Research Symposium

Here we aim to gain insight into the ecology of Azhdarchid pterosaurs. By exploring their genetic requirements and feeding capabilities, we gain a deeper understanding of what their day-to-day life may have looked like.

Biomedical Relation Extraction In The Era Of (Large) Language Models, Yuhang Jiang

Theses and Dissertations--Computer Science

Biomedical relation extraction is a key task in information extraction supporting downstream applications such as knowledge discovery, information retrieval, and question answering. As such, improvements in relation extraction (RE) are expected to have major implications for other information needs in biomedicine. In this dis- sertation, we pursue biomedical relation extraction in several advanced settings with recent advances in large language models (LLMs) and retrieval augmented generation (RAG). First, we address an important slot filling task on social media that arose during the Covid-19 pandemic, using the idea of continuous prompts with encoder models. Next, we handle a tricky dynamic n-ary …

Snake Venoms As Models For Understanding The Origins And Evolution Of Gene Regulatory Networks, Siddharth S. Gopalan

Biology Dissertations - Archive

Understanding the relationship between genotype and phenotype is a fundamental goal of biology. However, the vastly complex nature of eukaryotic gene regulation can make deriving precise relationships between genotype and phenotype challenging. The gene regulatory architecture of snake venom systems provide an opportunity to study this problem in a phenotypic system with immense variation in phenotypes and the underlying genetics. Using a set of integrated functional genomic approaches with snake venoms as a central model, in this dissertation, I provide several examples of the regulatory mechanisms by which diversity in phenotypes arises. Specifically, I identify how gene expression heterogeneity between …

Genetic Analysis Of Methionine Restriction-Associated Mitochondrial Unfolded Protein Response Signaling., Josh D. Dodge

Biology Dissertations - Archive

The lifespan of an organism is dictated by various genetic and environmental factors. One such determinant is the health of mitochondria which are organelles that mediate various critical cell functions including a significant role in generating the vast supply of cellular energy. Indeed, the gradual decline of mitochondrial function is believed to be a hallmark and possible cause of aging. Paradoxically, mild mitochondrial dysfunction early in life extends lifespan in various model organisms. Cells use diverse approaches to promote mitochondrial homeostasis, including the transcriptional reprogramming of cells by mitochondrial unfolded protein response (UPRmt) to mitigate mitochondrial stress. Consistently, UPRmt activation …

Understanding Middle School Teachers’ Content Knowledge And Pedagogical Content Knowledge For Effective Teaching Of The Nature Of Science, Austin C. Wilson

Curriculum and Instruction (Ed.D.) Dissertations

The purpose of this study was to examine middle school science teachers’ knowledge of the nature of science (NOS) and their pedagogical content knowledge (PCK) for teaching NOS. Developing students’ scientific literacy requires teachers who not only understand NOS but also know how to effectively integrate it into classroom instruction. This explanatory sequential mixed-methods study investigated in-service middle school science teachers’ NOS content knowledge (NOS-CK), their NOS-PCK, the relationship between these two constructs, and the extent to which demographic variables predicted teacher knowledge. NOS-CK and NOS-PCK data were collected from 61 teachers in a large suburban district through the Views …

Innovative Approaches To Combat Triple-Negative Breast Cancer: Integrating Metabolic Modulation, Advanced Therapies, And Lifestyle Interventions, Ngozi Damilola Chidumebi Akingbesote

Yale Graduate School of Arts and Sciences Dissertations

Triple-negative breast cancer (TNBC), an aggressive and often lethal subtype of breast cancer, continues to challenge researchers and clinicians due to its poor prognosis and limited therapeutic options. This thesis explores novel therapeutic strategies that integrate metabolic modulation, advanced radionuclide therapies, and lifestyle interventions to combat TNBC effectively. The first component investigates metabolic scaling and its implications for cancer metabolism. Gene and protein expression analyses across species reveal that metabolic processes, including oxidative metabolism and detoxification, scale inversely with body mass. This foundational insight underscores the importance of systemic metabolic regulation in understanding cancer progression. In the realm of cancer …

Applicability Of Multilateral Environmental Agreements During International Armed Conflicts, Beatrice L. Hamilton

Loyola University Chicago Law Journal

Armed conflicts increasingly contribute to environmental damage and climate change, yet, as proven by recent and ongoing conflicts, the legal framework for the protection of the environment under the law of armed conflict (LOAC) fails to effectively mitigate these damages. With rising temperatures, already diminishing resources, the counter-acting of mitigation and adaptation efforts due to warfare and geo-political tensions on the rise, there is a strong case for considering the potential for enhancing the protection of the environment during armed conflicts.

This Article examines the terms of applicability of multilateral environmental agreements (MEAs) during international armed conflicts. The article draws …

Mental Representations Of Computational Processes, Marlene Berke

Yale Graduate School of Arts and Sciences Dissertations

Human intelligence is uniquely powerful and flexible - operating in an enormous range ofsituations, from those as everyday as driving in traffic while carrying on a conversation, to those as extraordinary as cooperating to shift a culture. Work in cognitive science over the past decades has argued that two foundational types of representations form the building blocks of human intelligence: representations of the physical world in terms of objects, forces, spaces, substances, and so on (Carey, 2009), and representations of the social world in terms of agents and their mental states, like goals, beliefs, and knowledge (Gopnik, Meltzoff, & Bryant, …

Improving Thermal Comfort Of Firefighter Personal Protective Equipment With A Focus On Enhancing Insulation And Moisture Management Abilities: A Meta-Analysis, Hallie Ivory

Major Papers by TMD Master of Science Students

Firefighters wear personal protective equipment (PPE) composed of multiple layers, each designed to serve a specific function in ensuring safety and comfort in high heat environments. The thermal liner is the innermost layer and plays a crucial role in thermal comfort by providing insulation and moisture management. Insulation provides protection from external hazards while moisture management keeps the wearer cool and dry.

Heat stress is a significant safety concern for firefighters, as prolonged exposure to high temperatures and insufficient evaporative cooling can lead to discomfort, injuries and or fatalities for them while on duty. Effective moisture management is critical in …

Investigating Non-Canonical Roles Of Atr And Chk1 Throughout The Cell Cycle, Yoon Ki Joo

Yale Graduate School of Arts and Sciences Dissertations

Chromosome Instability (CIN), which results from DNA damage in interphase and chromosome missegregation in mitosis, is considered to be a potent driver of cancer. To prevent CIN, cells harbor the DNA Damage Response (DDR) pathway, which is responsible for detecting and repairing damaged DNA. Because of their importance in preventing CIN, the core members of the DDR pathway such as Ataxia Telangiectasia and Rad3-related (ATR) and Checkpoint kinase 1 (CHK1) have been studied as promising targets in cancer therapy. However, clinical trials show that ATR and CHK1 inhibitors elicit adverse side effects with unknown reasons. Recent research suggests that one …

Investigating The Structure And Assembly Of The Hiv-2 Capsid Protein: How Does It Compare To Its More Infamous Cousin?, Matthew David Cook

Yale Graduate School of Arts and Sciences Dissertations

Several million people live with infection by human immunodeficiency virus type 2 (HIV-2). Like its pandemic-causing relative, HIV-1, infection with HIV-2 can progress to AIDS, is largely incurable, and is similarly mutation-prone, presenting a challenge for treatment. Despite this, detailed study of HIV-2 is widely lacking while most of the understanding of the virus and its proteins is borne out of comparison with HIV-1. The two are sufficiently similar that this is generally effective, but differences in infection outcomes of the two viruses must be explicable by molecular determinants. One domain of viral biology particularly worth attention in this regard …

Resolving The Three-Dimensional Interactome Of Human Accelerated Regions During Human And Chimpanzee Neurodevelopment, Atreyo Pal

Yale Graduate School of Arts and Sciences Dissertations

Human Accelerated Regions (HARs) are regulatory elements highly conserved across species but exhibit a significant excess of human-specific sequence changes. They include transcriptional enhancers with human-specific activity and have been implicated in the evolution of the human brain. However, our understanding of how HARs contributed to uniquely human features of the brain is hindered by a lack of insight into the genes and pathways that HARs regulate. It is unclear whether HARs acted by altering the expression of gene targets conserved between HARs and their chimpanzee orthologs or by gaining new gene targets in human, a mechanism termed enhancer hijacking. …

Continization And Language Representation Of Chemical Information, Haote Li

Yale Graduate School of Arts and Sciences Dissertations

Throughout human history, our ancestors have continuously expanded the frontiers of their interests in nature. Chemistry is one of the essences of such explorations. Yet, despite countless discoveries and experiments, we are still on a journey to examine the possibilities within our finite time. With an ever-growing amount of information and open access to public resources, we are experiencing an inflection point. This moment redefines how efficiently we can solve problems, and the key lies in integrating increasing insights from the entire history of knowledge. Algorithms, in contrast to human efforts, are scalable with the amount of available hardware. In …

Mechanics And Energetics Of Cytoskeletal Assembly, Gao Sun

Yale Graduate School of Arts and Sciences Dissertations

Active matter is a subfield of soft condensed matter physics that focuses on the emergence ofcollective phenomena, as components of the system consume energy, driving them out of thermodynamic equilibrium. Living matter, a specific subfield of active matter, lies between physics and biology. In this case, the components are biomolecules, whose interactions are not only constrained by the laws of physics but may exhibit purpose and intentionality. Biophysicists, who study living matter use reductionist approaches and focus on how different components of the system can collectively give rise to novel biological phenomena through continuous consumption of energy. An example of …

Mechanisms Of Heart And Major Vessel Development: Nup107 And Cacna1g As Novel Regulators, Valentyna Kostiuk

Yale Graduate School of Arts and Sciences Dissertations

Congenital Heart Disease (CHD) is the most common congenital malformation and a leading cause of infant mortality. While advances in genomic sequencing technology have enabled a fast and inexpensive candidate gene identification, the molecular mechanisms of CHD remain mostly unknown. Both nup107 and cacna1g are novel CHD genes identified in CHD patients with no plausible mechanisms explaining their roles in cardiac development. Here, we show that nup107 plays a key role in early embryonic patterning and subsequent organ development. The loss of Nup107 has a direct impact on germ layer specification, Left-Right patterning and downstream cardiac looping. Specifically, Nup107 depletion …

Visual Circuits For Distance Estimation In Walking Drosophila, Joseph Shomar

Yale Graduate School of Arts and Sciences Dissertations

Animals must infer the three-dimensional structure of their environment from twodimensional retinal images. They use visual cues like motion parallax and binocular disparity to judge distances to objects, and studies across several animal models have foundand characterized neural signals that correlate with visual distance. However, the causal role of these neurons in distance estimation and the range of their possible neural properties remain poorly understood. Here we show that both directional and non-directional feature-selective neurons in the Drosophila visual system are involved in distance estimation during free locomotion. We used a high-throughput behavioral assay to perform a targeted silencing screen …

Bioinformatic, Genetic, And Biochemical Investigations Of The Bacterial Ole Ribonucleoprotein Complex, Chrishan Malinda Fernando

Yale Graduate School of Arts and Sciences Dissertations

Bacteria are under significant evolutionary pressures to maintain compact genomes.Therefore, they typically have high coding density compared to eukaryotes. As a result, large and highly structured noncoding RNAs (ncRNAs) are extremely rare in bacteria. However, the few classes of known large ncRNAs have unique and fundamental biological roles and are often catalytic. Furthermore, these ncRNAs reveal what may have been possible under a hypothetical ancient RNA world in which all major biological functions in existing organisms were performed by RNA, rather than DNA and protein. Further study of large ncRNAs is likely to reveal new insights into RNA catalysis and …

Analysis Of The Papillomavirus L2 Capsid Protein Structure And Protrusion, Patrick Michael Buckley

Yale Graduate School of Arts and Sciences Dissertations

Approximately 5% of human cancer worldwide is caused by Human Papillomavirus (HPV). Although there are highly effective prophylactic vaccines, HPV remains a serious public health challenge due to low vaccine uptake and the inability of the vaccine to treat anyone already infected. Understanding how HPV enters and infects cells is important, as this work may lead to the development of new antivirals or therapeutics and may also reveal new aspects of cell and protein biology. HPVs are non-enveloped viruses, containing an ~8000 base pair double-stranded DNA genome encapsidated by 360 copies of L1 major capsid protein and up to 72 …

Asymmetric Synthesis Of Bioactive Scaffolds Via Organocatalysis, Melody Guo

Yale Graduate School of Arts and Sciences Dissertations

Chiral catalysts allow chemists to access enantioenriched materials without the use of proportionate amounts of chiral reagents, while lowering the energy barrier of the original reaction. One way to form bioactive, heteroatom-containing scaffolds asymmetrically is through the use of chiral organocatalysts. This dissertation covers the development of stereoselective reaction methodology to access bioactive scaffolds and mechanistic investigations into intriguing features therein. Chapter 1 describes the development of the asymmetric synthesis of axially chiral quinazolinones. In this project, complementary applications for two different scaffold classes of chiral phosphoric acid (CPA) catalysts are found. We observe that while a C2-symmetric CPA catalyst …

The Role Of Local Factors In Shaping Microbial Communities And Biogeochemical Functions Across Scales, Alexander Polussa

Yale Graduate School of Arts and Sciences Dissertations

Microorganisms play a vital role in carbon cycling, driving the decomposition and transformation of organic matter (OM) in soils. This dissertation examines how both broad climatic and local factors shape microbial communities and influence organic matter decomposition. Through a combination of microcosm and field experiments, I demonstrate that local conditions like soil moisture, depth and plant identity impact microbial function, although these effects can be masked by broader climatic influences. I also investigate how the ericoid shrub, Kalmia latifolia, differentially affects fungal communities under arbuscular and ectomycorrhizal trees. Finally, integrating results from multiple forest sites in the eastern US, I …

Understanding The Mechanisms Regulating Neuronal Metabolic States In Vivo, Milind Singh

Yale Graduate School of Arts and Sciences Dissertations

Glycolysis, a glucose-consuming pathway required for cellular energy production, iswell conserved across species and has been extensively characterized biochemically. Less is understood regarding how it is subcellularly organized, or coordinated across tissues in vivo. Previous work from our lab found that during transient hypoxia or neuronal stimulation, the rate-limiting glycolytic enzyme phosphofructokinase-1 (PFK-1.1) dynamically re-localizes from the cytoplasm to condensates near synapses in C. elegans neurons. My research examined mechanisms by which PFK-1.1 localization is regulated in neurons, and resulted in two main findings: 1) PFK-1.1 condensate formation in neurons is regulated by a non-cell-autonomous signal derived from hypodermal (epidermal) …