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2025

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An Analysis Of Dguok Variants Associated With Mitochondrial Dna Depletion Syndrome, Elaine Vanterpool, Ethan Harris Jan 2025

An Analysis Of Dguok Variants Associated With Mitochondrial Dna Depletion Syndrome, Elaine Vanterpool, Ethan Harris

Student Posters

Mitochondrial DNA Depletion Syndrome(MDDS) is a clinically heterogeneous group of autosomal recessive mitochondrial disorders that reduces the number of mitochondrial DNA (mtDNA) in the affected cells. This disease is characterized by the disruption of hepatocytes, skeletal muscle, and cerebral function. This study's purpose is to identify and assess the pathogenicity of DGUOK variants associated with MDDS.

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Analysis Of Dmd Variants Associated With Duchenne Muscular Dystrophy, Elaine Vanterpool, K’Sia Byass Jan 2025

Analysis Of Dmd Variants Associated With Duchenne Muscular Dystrophy, Elaine Vanterpool, K’Sia Byass

Student Posters

Duchenne Muscular Dystrophy is an X-linked recessive disorder that causes muscle weakness. This disease is characterized by frequent falls, difficulty walking, running, jumping, or scoliosis. Duchenne Muscular Dystrophy 1 in every 5000 boys worldwide causes a gene tic mutation that prevents the production of dystrophin. This study aims to identify and assess the pathogenicity of DMD variants associated with Duchenne Muscular Dystrophy. Genetic mutations responsible for Duchenne Muscular Dystrophy have been reported. Studies regarding DMD and its specific role in causing Duchenne Muscular Dystrophy have been reported to be accurate and effective. X-linked inheritance patterns are applied to this disease's …

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Investigating Alk, Phox2b, And Brca2 Gene In Relation To Neuroblastoma, Elaine Vanterpool, Joshua Henry Jan 2025

Investigating Alk, Phox2b, And Brca2 Gene In Relation To Neuroblastoma, Elaine Vanterpool, Joshua Henry

Student Posters

One of the biggest mysteries of cancer today is Neuroblastoma. Neuroblastomas are malignancies originating from the early nerve cells of the sympathetic nervous system, often known as neuroblasts. Neuroblasts can occur anywhere throughout the sympathetic nervous system. About one-third of infants are diagnosed with neuroblastoma by the time they turn one year old and the disease frequently starts in infancy. By the age of five, almost 75% have a diagnosis. Neuroblastomas are present in some newborns, but they are not identified until later, when the child or infant starts exhibiting symptoms. Adult cases of NB are quite rare. The majority …

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The Syntax Of Sports Class 7: Information Flow, Patrick Barry Jan 2025

The Syntax Of Sports Class 7: Information Flow, Patrick Barry

Books

What can sports fans who start “the wave” at a big stadium teach us about getting people to speak up in class or at an important meeting? What can the poet Maya Angelou and the boxer Joe Louis teach us about streamlining sentences and paragraphs? And how exactly do we get our ideas to flow in powerfully persuasive ways? Explore these and other questions in the seventh volume of The Syntax of Sports, a series based on the innovative and highly interdisciplinary courses Professor Patrick Barry teaches at the University of Michigan.

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Beyond The Surface: Lgbt+ Minority Stress & Social Safety, Violet Lewis Jan 2025

Beyond The Surface: Lgbt+ Minority Stress & Social Safety, Violet Lewis

A with Honors Projects

Presentation about minority stress in the LGBT+ community surrounding the recent political climate and how we can use social safety to deter the impacts.

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State Responsibility For Disrupting Earth’S Climate System: Anticipating The Icj Advisory Opinion, Natalia Urzola, Nicholas A. Robinson, Léonore Gaboardi Carandell, Daye Chen, Bryce Clark, Madison Routledge Pettus Jan 2025

State Responsibility For Disrupting Earth’S Climate System: Anticipating The Icj Advisory Opinion, Natalia Urzola, Nicholas A. Robinson, Léonore Gaboardi Carandell, Daye Chen, Bryce Clark, Madison Routledge Pettus

Elisabeth Haub School of Law Faculty Publications

In 2025, the International Court of Justice (ICJ) will deliver an advisory opinion on the legal obligations of nations with respect to the mounting damage caused by climate change. This ruling will definitively restate applicable international law, provide a basis for new global policy decisions within the U.N. General Assembly, and provide a predicate for new lawsuits in national courts. To be effective, remedies for breaching a government's duties to avert climate change will require a “collective remedy,” not merely financial compensation. This ruling was sought by law students from the South Pacific and elsewhere; this Article, also by young …

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Investigation Of Heterosynaptic Long-Term Potentiation Of Non-Nociceptive Synapses, Synaptically Relevant Kinase Discovery, And Virtual Screening For A Pkmz Inhibitor In Hirudo Verbana", Avery Franzen Jan 2025

Investigation Of Heterosynaptic Long-Term Potentiation Of Non-Nociceptive Synapses, Synaptically Relevant Kinase Discovery, And Virtual Screening For A Pkmz Inhibitor In Hirudo Verbana", Avery Franzen

Dissertations and Theses

There is a considerable lack in efficacy for current chronic pain treatments. One therapy that has gained attention are cannabinoid-based medications. However, preclinical and clinical trials do not produce anti-nociceptive results consistently and occasionally produce pro-nociceptive results. Understanding this ambiguity between anti-nociceptive and pro-nociceptive effects is vital to cannabinoids’ future utilization. One symptom of chronic pain conditions is allodynia in which pain is perceived following non-painful stimuli. This may be due to non-nociceptive afferents activating nociceptive circuitry in an abnormal manner. Using the medicinal leech, Hirudo verbana, we have begun to elucidate mechanisms by which endocannabinoids strengthen non-nociceptive afferent synapses. …

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The Role Of Grades On Learning In Higher Education, Kindra Schneider Jan 2025

The Role Of Grades On Learning In Higher Education, Kindra Schneider

Dissertations and Theses

This study examines grading in higher education from two distinct perspectives: graduate students’ perceptions of a grading scheme that utilizes rubrics and self-assessment and instructors’ perceptions of academic freedom in grading. The first study examined graduate students’ perspectives on a grading scheme utilizing rubrics and self-assessment. Data from focus groups and journals revealed four main themes: the importance of clear expectations, enhanced synergy between rubrics and self-assessment when transparency increased, bias towards rubrics based on more exposure, and mixed feelings surrounding perceptions of self-assessment and its influence on learning. The second study investigated non-tenured faculty’s perceptions of academic freedom in …

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Social Anxiety And Cannabis Use Context, Brooke Beckius Jan 2025

Social Anxiety And Cannabis Use Context, Brooke Beckius

Dissertations and Theses

Cannabis use is highly prevalent among young adults in the United States, with many experiencing associated problems. Social anxiety has been identified as a significant risk factor for cannabis use and related consequences; however, it remains unclear whether cannabis facilitates or inhibits social engagement among socially anxious individuals. Solitary cannabis use is consistently linked to use-related problems, but the term “solitary use” may encompass distinct contexts—such as social preparatory use, use to aid sleep, or use while spending time alone. The present study aimed to examine how cannabis use influences social engagement among socially anxious individuals and test how specific …

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Administrative Forum Shopping, Amy L. Stein Jan 2025

Administrative Forum Shopping, Amy L. Stein

Fordham Law Review

Allowing private parties in litigation to stack the deck in their favor through forum shopping is standard fare in the United States. But not everyone realizes that public legislators engage in a similar exercise when they stack the deck in one party’s favor through “jurisdiction-stripping” or “jurisdiction-channeling” provisions. Congress can strip federal courts of all or some of its jurisdiction, channel jurisdiction over a particular class of cases into one particular court, and even strip the U.S. Supreme Court of its appellate jurisdiction. Understandably, this last category has received the most attention, as scholars are drawn to the penultimate conflict …

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Novel Infection By Mucor Hiemalis Kills Caenorhabditis Hosts Through Intestinal Perforation, Jay Ni Jan 2025

Novel Infection By Mucor Hiemalis Kills Caenorhabditis Hosts Through Intestinal Perforation, Jay Ni

West Chester University Graduate Theses, Dissertations, and Final Projects

The nematode Caenorhabditis elegans has emerged as a popular model system to investigate cell biology and host-pathogen interactions. Presently, C. elegans is studied as a natural host of intracellular pathogens such as microsporidia and Orsay virus along with extracellular bacterial and fungal pathogens. The use of C. elegans as a model in host-pathogen research is limited by the number of naturally occurring pathogens to the organism. Through a sampling project to identify new pathogens of C. elegans, we identified the fungus Mucor hiemalis as a pathogen of Caenorhabditis species. We observed the fungus in the intestinal lumen of wild-caught …

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Silver Nanoparticles And Vanillin Can Inhibit Collagenase Activities Of Serratia Marcescens, Elaine Vanterpool Jan 2025

Silver Nanoparticles And Vanillin Can Inhibit Collagenase Activities Of Serratia Marcescens, Elaine Vanterpool

Student Posters

Serratia marcescens is a gram-negative, disease-causing agent that belongs to the Enterobacteriaceae family. This rod-shaped microbe causes many infectious diseases such as urinary and respiratory infections, wound infections, and peritonitis, which can result in fatal bacteremia. Protease is a virulence factor of S. marcescens that enhances its pathogenicity by breaking down proteins via cleavage of peptide bonds. The purpose of this research is to identify testing agents that reduce the protease mediated pathogenicity of S. marcescens

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An Analysis Of Diabetes Associated With Appl1 Variants D94n And R46w, Elaine Vanterpool, Gaielle Price Jan 2025

An Analysis Of Diabetes Associated With Appl1 Variants D94n And R46w, Elaine Vanterpool, Gaielle Price

Student Posters

Diabetes is a long-term metabolic illness with high blood glucose (blood sugar) levels. Over time, this condition can cause major harm to the heart, blood vessels, eyes, kidneys, and nerves. Around 830 million people in the world with diabetes reside in low- and middle-income environments (World Health Organization). This study aims to identify and assess the pathogenicity of APPL1 variants associated with diabetes.

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Implications Of Pik3ca On Breast And Ovarian Cancer, Elaine Vanterpool, Kaylani Krigger Jan 2025

Implications Of Pik3ca On Breast And Ovarian Cancer, Elaine Vanterpool, Kaylani Krigger

Student Posters

Breast and ovarian cancer are two of the most prevalent diseases affecting women. Ovarian cancer is a disease defined by the presence of tumors in the ovaries. Breast cancer is the uncontrollable cell growth of breast tissue leading to tumor formation. BRCA 1/2, PALB2, TP53, and PTEN are common gene mutations found present in breast and ovarian cancer. The PIK3CA gene mutation is less frequent, however, its mutations are almost exclusively tied to breast and ovarian cancer. Forty percent (40%) of breast cancers and thirty percent (30%) of ovarian cancers have a mutation in the PIK3CA/AKT signaling pathway (Chen et …

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Improving Biocompatibility And Structural Integrity Of Decellularized Biomaterials, Elaine Vanterpool Jan 2025

Improving Biocompatibility And Structural Integrity Of Decellularized Biomaterials, Elaine Vanterpool

Student Posters

Tissue engineering is a revolutionary approach to regenerative medicine. Within the field of tissue engineering, biomaterials such as the great saphenous vein or synthetic materials such as PET, are used in tissue generation for grafts and wound healing in many other uses. This is promising and has the potential to save many lives, but many glaring issues prevent the use of these scaffolds in a clinical setting. Some of these include body rejection, lack of hemocompatibility, and weak structural integrity.

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The Role Of Nkx2-5 Variants Associated With Congenital Heart Disease, Elaine Vanterpool, Jayda Russell Jan 2025

The Role Of Nkx2-5 Variants Associated With Congenital Heart Disease, Elaine Vanterpool, Jayda Russell

Student Posters

About 1% of live births worldwide are affected by congenital heart disease (CHD), a group of structural heart defects that exist from birth. Finding and evaluating the effects of NKX2-5 variations linked to CHD is the goal of this study. From basic heart defects like atrial septal defects (ASD) to more intricate malformations, congenital heart disease (CHD) encompasses a variety of structural heart abnormalities. Its development is influenced by both environmental and genetic factors. NKX2-5 is a protein coding gene that encodes a home box- containing a transcription factor. This gene plays a role in the early development of the …

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The Analysis Of Variants Of The Atm Gene In Breast Cancer, Elaine Vanterpool, Kyah Miller Jan 2025

The Analysis Of Variants Of The Atm Gene In Breast Cancer, Elaine Vanterpool, Kyah Miller

Student Posters

Breast Cancer is defined as abnormal cell growth within the breast tissue, resulting in a tumor. Those affected by this disease often experience lumping in the breasts, changes in breast size and shape, nipple retraction, skin dimpling, and redness and irritation of the breast. This disease most commonly affects women, but men can be affected as well. Although subject to variation due to race and ethnicity, approximately 13% of women will be diagnosed with breast cancer throughout their lifetime. With further study and new treatment methods, the mortality rate is steadily decreasing. The purpose of this research is to analyze …

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An Electrochemical Sensor For Tenofovir Monitoring, Abdellatif Ait Lahcen, Gymama Slaughter Jan 2025

An Electrochemical Sensor For Tenofovir Monitoring, Abdellatif Ait Lahcen, Gymama Slaughter

Center for Bioelectronics Publications

Effective monitoring of tenofovir (TFV) adherence is critical for ensuring the success of antiretroviral therapies in preventing and managing HIV, as nonadherence can lead to treatment failure and the development of drug-resistant strains. In this study, a highly sensitive and selective novel biomimetic sensor for TFV determination is developed utilizing laser-scribed graphene (LSG) modified with gold spiky nanostructures (AuNSp) and molecularly imprinted polymer (MIP). The MIP layer is engineered with precise control to maximize molecular specificity for TFV. Electrochemical characterization demonstrates excellent performance, including the broadest linear detection range (10 nM to 200 μM) reported to date with a sensitivity …

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Analysis Of Wwox Gene Associated With Cancer, Elaine Vanterpool, Jovaughn Redley Jan 2025

Analysis Of Wwox Gene Associated With Cancer, Elaine Vanterpool, Jovaughn Redley

Student Posters

Cancer is a disease caused by abnormal cell growth and uncontrollable spread throughout one’s body. According to the World Health Organization, about 1 in 5 people develop cancer: 1 in 9 in males and 1 in 12 in females (WHO). WWOX was the gene studied, and it has been reported to be involved in cancer progression. Specifically with Gastric cancer, an increase in invasion and migration of Gastric Cancer cells was caused by the WWOX gene. Simple ClinVar was used to identify WWOX as a gene and the three missense variants associated with the WWOX gene; Pro47Thr, Asp58Asn, and His46Tyr. …

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An Analysis Of Pdgfra Variants Associated With Fibroids, Elaine Vanterpool, Nadja Hunt Jan 2025

An Analysis Of Pdgfra Variants Associated With Fibroids, Elaine Vanterpool, Nadja Hunt

Student Posters

Originally research was to be conducted on the effects of gene mutations associated with endometriosis, but there was not a substantial amount of information in the database for an adequate study. Instead, research was done on the genes associated with Fibroids. Fibroids are commonly characterized as benign tumors that typically form in the wall of the uterus. Fibroid symptoms usually include heavy menstrual bleeding, prolonged periods, and pelvic pain. In some cases, there are no symptoms. Statistically, fibroids affect 20–30% of women ages 30–50. This study’s purpose is to identify and analyze the pathogenicity of PDGFRA (platelet-derived growth factor receptor …

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January 2025 News Releases, University Of Montana--Missoula. Office Of University Relations Jan 2025

January 2025 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

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Sptiotemporal Changes In Aboveground Biomass, Canopy Cover And Livestock Movements Across Mongolia Grasslands, Abhinav Chandel Jan 2025

Sptiotemporal Changes In Aboveground Biomass, Canopy Cover And Livestock Movements Across Mongolia Grasslands, Abhinav Chandel

Dissertations and Theses

This study presents an integrated geospatial framework for understanding grassland productivity dynamics and livestock movement behavior across the Mongolian steppe. Mongolia’s grasslands constitute one of the world’s largest pastoral ecosystems, yet they face increasing vulnerability due to climate variability, overgrazing, and land degradation. To quantify vegetation change and grazing responses, this research combines multi-decadal remote sensing with high-frequency GPS-based livestock movement tracking. Using Landsat imagery from 1990 to 2023, Aboveground Biomass (AGB) and Canopy Cover (CC) were estimated through Random Forest regression models integrating key spectral vegetation indices (e.g., NDVI, OSAVI, CTVI, TNDVI, IPVI) and climatic predictors such as summer …

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Estimating The Amount Of Carbon Dioxide Gas Removed From The Atmosphere By The Bryant Park Tree Population, Edimarlyn Gonzalez Jan 2025

Estimating The Amount Of Carbon Dioxide Gas Removed From The Atmosphere By The Bryant Park Tree Population, Edimarlyn Gonzalez

Open Educational Resources

No abstract provided.

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Investigating The Impact Of Pfas Contamination On Mental Health, Jihyun Kim Jan 2025

Investigating The Impact Of Pfas Contamination On Mental Health, Jihyun Kim

Open Educational Resources

To explore the intersection of environmental injustice, racial disparities, and public health through an examination of PFAS contamination in drinking water and its impact on communities of color. This study will address environmental, social, and health implications of PFAS exposure, with a specific emphasis on promoting equity and advocating for policy changes to rectify systemic inequalities.

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An Introduction To Cultural Anthropology: What Does Anthropology Offer The Current World?, Kristina Baines, Victoria Costa, Baird Campbell Jan 2025

An Introduction To Cultural Anthropology: What Does Anthropology Offer The Current World?, Kristina Baines, Victoria Costa, Baird Campbell

Open Educational Resources

This Open Educational Resource (OER) is designed to be used as a textbook to accompany an introductory course in Cultural Anthropology. The chapters can, however, stand alone or be expanded and be used in courses with units on Medical Anthropology, Ethnographic Methods, Race and Gender Studies, Climate and Environmental Anthropology and others. Please feel free to use all or part of the textbook and supplemental materials provided. This resource is published under a creative commons license. Use and modify as you wish for non-commercial use only with attribution to Cool Anthropology.

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Least Tern Abundance, Nesting Productivity, And Dispersal Between Nesting And On- And Off-River Foraging Sites In The Missouri National Recreational River, Kyle Jorgensen Jan 2025

Least Tern Abundance, Nesting Productivity, And Dispersal Between Nesting And On- And Off-River Foraging Sites In The Missouri National Recreational River, Kyle Jorgensen

Dissertations and Theses

The Interior Least Tern (Sterna antillarum athalassos) has experienced significant conservation success, culminating in its removal from the federal endangered species list in 2021. However, the species remains state-endangered in South Dakota, and knowledge gaps persist regarding its foraging ecology and population dynamics along the Missouri National Recreational River (MNRR). This study aimed to address these gaps by quantifying Least Tern abundance, nesting productivity, and movement patterns between nesting and foraging sites during the 2024 and 2025 breeding seasons. We conducted surveys of Least Terns on riverine sandbars and off-river wetlands within a 30-km radius of the MNRR, employing both …

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“We All Agree That The Best Thing To Do Is Be Kind To Ourselves”: Emotionally Reflexive Reorientations Of Childcare During The Covid Pandemic, Mary Holmes Jan 2025

“We All Agree That The Best Thing To Do Is Be Kind To Ourselves”: Emotionally Reflexive Reorientations Of Childcare During The Covid Pandemic, Mary Holmes

Irish Journal of Applied Social Studies

In the face of a crisis like COVID-19, people in the UK mused on how they felt and how to care, including how to care for children. This musing can be understood as emotional reflexivity: which means reflecting on how to feel and how to use those reflections in our emotional practices. I illustrate emotional reflexivity at work in 47 volunteer writers’ responses to the Mass Observation Project’s special COVID directive in March 2020. It asked the writers to share their experiences as the COVID-19 pandemic unfolded. They did their emotional reflexivity with other people and sometimes reoriented caring for …

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Mobility-Stress Dynamics: What Audit Scores Can Tell Us About Mobility Patterns And Stress, Mason Hatwan Jan 2025

Mobility-Stress Dynamics: What Audit Scores Can Tell Us About Mobility Patterns And Stress, Mason Hatwan

Dissertations and Theses

This dissertation, leveraging secondary data from the Colorado EMA Project, investigates the dynamic relationships between mobility patterns, stress, and alcohol-related negative consequences among undergraduate college students (N=182, Mage 18.47). Grounded in Dynamic Systems Theory (DST), the study explores daily variations in mobility and stress using a Dynamic Structural Equation Model (DSEM). The analysis aims to understand how these variables interact within and between individuals, focusing on the role of baseline alcohol-related negative consequences as measured by the Alcohol Use Disorders Identification Test (AUDIT). Findings reveal a significant autoregressive effect for stress, indicating that higher stress on one day predicts higher …

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Understanding Motivations For Graduate Assistant Unionization At A Large, Private, Elite Research University In The Midwest, Cynthia Shannon-Hutchison Jan 2025

Understanding Motivations For Graduate Assistant Unionization At A Large, Private, Elite Research University In The Midwest, Cynthia Shannon-Hutchison

Dissertations of Practice

The right of graduate student workers to unionize at private universities within the United States was reconfirmed in 2021 after years of uncertainty. The focus of this study was to understand specific challenges and desires, beyond wages and benefits, that drove students at a large private research university to organize for collective bargaining. This instrumental case study used constructivist grounded theory methodology to explore the motivations and issues that prompted students to unionize at a large, private, elite research university in the Midwest of the United States. The study provides insights into specific issues that were the platform for organizing, …

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Analysis Of Recreational Data On Nearby Rivers, Rachael Meyers, Tamara Johnstone-Yellin Jan 2025

Analysis Of Recreational Data On Nearby Rivers, Rachael Meyers, Tamara Johnstone-Yellin

ASPIRE 2025

In the 1980’s. DuPont of Waynesboro, VA, contaminated over 100 miles of river on the South Fork of the Shenandoah and the South River. As part of their settlement, creel surveys are completed routinely by the Department of Wildlife Resources to collect data on angler and recreational use of these rivers. This project uses the recreational data to determine; ‘where on the South Fork of the Shenandoah River is recreational access the heaviest?’ ‘what forms of recreational use are most popular, and is there a change from 2016 to 2023?’ and ‘are there differences in the demographics of recreational users …

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