Digital Commons Network^™

Disparity In Human Rights Violations: A Political And International Law Perspective, Aidir Amin Daud

Hasanuddin Law Review

Right to life is non-derogable rights. A natural right that should not be revoked arbitrarily by anyone, including the state. A mass murder in events 1 October 1965 and Timor-Timor is a double series of states’ failure in protecting the rights of Indonesian peoples. Moreover, these two events get different treatment in its handling. The disparity in treatment between two cases is a big question related to the consistency of human rights enforcement in Indonesia. This study is a descriptive-qualitative research. While, to prove the truth, this study will use a comparative study. The findings show that the attitude of …

Research On Path Planning Method For Autonomous Underwater Vehicles Based On Improved Informed Rrt, Bensheng Qi, Yan Li, Hongxia Miao, Jialin Chen, Chenglin Li

Journal of System Simulation

Abstract: In response to the autonomous underwater vehicle (AUV) path planning problem in complex underwater environments, an improved path planning algorithm based on Informed rapidly-exploring random trees (RRT) is proposed in this study. A target-biased sampling strategy and a target-biased extension strategy are employed to address the issue of lack of goal orientation in the sampling process, ensuring that target nodes become sampling points during random sampling. During path points extension, non-target sampling points are guided in the direction of the target point, thereby enhancing the algorithm's ability to search for the target during random sampling and extension processes. A …

The Design And Cell-Free Protein Synthesis Of A Pembrolizumab Single-Chain Variable Fragment, Landon E. Ebbert, Tyler J. Free, Mehran Soltani, Bradley Charles Bundy

Faculty Publications

Background/Objectives: Cancer is a leading cause of death. However, recently developed immunotherapies have shown significant promise to improve cancer treatment outcomes and survival rates. Pembrolizumab, a cancer immunotherapy drug, enables a strong T-cell response specifically targeting cancer cells to improve patient outcomes in more than 16 types of cancer. The increasing demand for pembrolizumab, the highest selling drug in 2023, increases global dependence on drug production, which can be vulnerable to supply chain disruptions. Methods: Cell-free protein synthesis (CFPS) is a rapid in vitro protein production method that could provide the production of an immunotherapy drug in an emergency and …

Modifiable Factors For Irritable Bowel Syndrome: Evidence From Mendelian Randomisation Approach, Di Liu, Meiling Cao, Shanshan Wu, Yiwen Jiang, Weijie Cao, Tengfei Lin, Fuxiao Li, Feng Sha, Zhirong Yang, Jinling Tang

Research outputs 2022 to 2026

Background The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the modifiable factors associated with IBS, while accounting for the impact of unobserved confounders and coexisting disorders. Methods Genetic correlation and Mendelian randomisation (MR) analyses were integrated to identify potential modifiable factors and coexisting disorders linked to IBS. Subsequently, multiresponse MR (MR 2) was employed to further examine these associations. Summary-level genome-wide association data were used. Modifiable factors and coexisting disorders (ie, gastrointestinal and psychiatric disorders) were identified based on evidence from cohort studies and meta-analysis. In all analyses, IBS …

Editorial: Vitamin D And Mineral Ion Homeostasis: Endocrine Dysregulation In Chronic Diseases, Rahnuma Ahmad, Bara Sarraj, Mohammed S. Razzaque

School of Medicine Publications

No abstract provided.

Municipal Solid Waste Management In Egypt Environmental And Economic Objectives, Nader Ibrahem Ismael

Mansoura Engineering Journal

The research aims to study the problem of municipal solid waste in Egypt, which notes the growth of the phenomenon of dumping this waste in the streets of Egypt, especially following the January 25 revolution and the resulting shortcomings in the performance of successive governments in confronting this problem, which led to an increasing rate of solid waste accumulation in the streets of Cairo and the shortcomings of the administrations’ performance. There is also a lack of a specific methodology for collecting local waste at the republic level. The research aims to develop a methodology for managing these wastes, starting …

Faunistic Study Of Some Fouling Species Associated With Pearl Oysters, Including A New Record For The Egyptian Mediterranean Sea, Khaled M. Abdelsalam, Noha H. Elebiary

Blue Economy

The objective of this study is to redescribe four marine fouling species on Al Dhahab Island in front of Miyami Beach, Alexandria, that are associated with the pearl oyster Pinctada radiata (Leach, 1814). During June 2021, eighteen shells of P. radiata oysters were collected by scuba diving. Analyzed fouling communities revealed that a total of 106 taxa were associated with the studied shells, among these two polychaetes (Lepidonotus carinulatus and Eurysyllis tuberculata), one bivalve (Septifer cumingii), and one isopod (Munna sp.) were recorded. The fourth species, identified as Uromunna petiti (Amar, 1948), constitutes a new record for the Egyptian Mediterranean …

Monstrosity And Ecophobia In Frankenstein, Moby Dick, And Dracula, Enas Hassouneh, Raja Al-Khalili

Jordan Journal of Applied Science-Humanities Series

Since ancient times, images of monsters have appeared in many works and served as embodiments of human fears and sources of ecophobia. Monstrosity evoked contempt, hatred, and ultimately ecophobia, which Estok describes as irrational fear, contempt, or lack of mindfulness toward the natural environment. This paper explores the character of the monster as an embodiment of ecophobia in three Gothic novels: Mary Shelley’s Frankenstein (1818), Herman Melville’s Moby Dick (1851), and Bram Stoker’s Dracula (1897), by interpreting monstrosity in socio-cultural contexts. The following questions will be addressed: How is monstrosity represented? How do monsters exhibit ecophobia? What role does the …

Feasibility And Acceptability Of The Mazi Umntanakho Digital Tool In South African Settings: A Qualitative Evaluation, Catherine E. Draper, Caylee J. Cook, Elizabeth A. Ankrah, Jesus A. Beltran, Franceli L. Cibrian, Kimberley D. Lakes, Hanna Mofid, Lucretia Williams, Gillian R. Hayes

Engineering Faculty Articles and Research

To address the need for interventions targeting social emotional development and mental health of young children in South Africa, the Mazi Umntanakho (‘know your child’) digital tool was co-designed, and piloted with caregivers and 3–5-year-old children involved in home visiting programmes promoting early childhood development. The aim of this study was to qualitatively evaluate the feasibility and acceptability of this tool in four urban and four rural low-income communities, from the perspective of home visitors and caregivers. Focus groups were conducted with home visitors (n = 117) and caregivers (n = 72). Issues relating to the feasibility of …

The Clinical Utility Of A Next-Generation Sequencing-Based Approach To Detecting Circulating Hpv Dna In Patients With Advanced Anal Cancer, Deepak Bhamidipati, Jay R Johnson, Kangyu Lin, Helene Pelicano, Cathy Eng, Ryan Huey, Robert A Wolff, Daniel M Halperin, Michael F Frumovitz, Ignacio I Wistuba, Dzifa Y Duose, Saradhi Mallampati, Rajyalakshmi Luthra, Van K Morris

Faculty, Staff and Student Publications

Background: To extend the practicality of liquid biopsy beyond the historical HPV circulating tumor DNA (ctDNA) assays, we evaluated the clinical relevance of a novel next-generation sequencing HPV ctDNA assay in patients with locally advanced and metastatic squamous cell cancer of the anal canal (mSCCA).

Methods: ctDNA isolated from the plasma of patients with mSCCA was sequenced using a 1.4 Mb hybrid-capture target-enrichment panel covering the whole genome sequences of all 193 HPV types. The HPV type, copy number (CN), and integration sites were determined using a bioinformatic pipeline.

Results: A total of 77 plasma samples from 28 patients with …

Neighborhood Social Processes And Adolescents' Depressive Symptoms: The Intervening Role Of Neighborhood Self-Efficacy, Kristen A. Berg

Faculty Scholarship

Via observational data from the Project on Human Development in Chicago Neighborhoods collected between 1994 and 2001, this study examined the degree to which neighborhood disorder, collective efficacy, and youth-centered institutional resources are directly associated with adolescents' depressive symptoms across time, and the mediating role of adolescents'neighborhood self-efficacy. Latent variable structural equation models were estimated among an unweighted representative sample of 1448 adolescents (59% male, mean age 15.19), across 79 neighborhoods in Chicago, to examine the direct effects of neighborhood disorder, collective efficacy, and availability of youth-centered resources at baseline (measured at timepoint 1; reported by an independent sample of …

The Healing Power Of Antitrust, Theodosia Stavroulaki

Northwestern University Law Review

Millions of Americans live in hospital deserts—communities where people lack geographic access to hospitals and primary care physicians. People living in these deserts often miss doctor appointments, delay necessary care, and stop adhering to their treatment. In this way, hospital deserts exacerbate the health disparities plaguing America. This Article demonstrates that hospital deserts are not inevitable but the result of several business strategies—including noncompete agreements and merging with competitors—and antitrust enforcers’ unwillingness to recognize these harmful practices as antitrust violations. To cure the issue of hospital deserts, this Article makes three proposals. First, antitrust enforcers and the courts should expand …

Computational Investigation Of The Unveils Nsd2 Inhibition Potential Of Berberis Vulgaris, Sambucus Nigra, And Morus Alba Through Virtual Screening, Molecular Docking, Md Simulation, And Dft Analyses, Supriyo Saha, Vanshita Gupta, Ahad Hossain, Prinsa Prinsa, Jannatul Ferdous, Kiran Bharat Lokhande, Vikash Jakhmola, Sarkar M. A. Kawsar

Karbala International Journal of Modern Science

Nuclear receptor binding set domain protein 2 (NSD2) plays a key role in chromatin regulation and is associated with different cancers and other developmental problems. Berries are rich in major secondary metabolites with anticancer properties. Here, we virtually screened 145 berry phytochemicals as putative NSD2 inhibitors via structure-based virtual screening, molecular docking, MD simulations, and DFT and ADMET analyses. Among them, α-carotene had the maximum docking score of -9.9 kcal/mol, followed by sulfuretin and β-amyrin. MD simulation analysis revealed that the dynamic behavior of the ligand‒NSD2 complexes was within the limit, indicating no significant changes in the structural integrity of …

Antimicrobial Effect Of Herbs Extracted With Ethanol Compared To Ampicillin, Brianna Neilan, Laura Rowe

Posters-at-the-Capitol

Antibiotics are commonly used to treat bacterial infections within the medical field, however there are growing concerns of antibiotic resistance. Before the introduction of antibiotics herbs were commonly used to treat infections, and herbal medicine is still used in many communities and cultures. Bacteria’s increasing resistance to traditional antibiotics has caused herbal medicines to become a significant research topic recently. Methods of herbal medicine preparation include preparing teas using hot water, and tinctures that soak herbs in alcohol for several weeks. Previous research has shown significant antimicrobial effects of some herbs when soaked in water and other liquids. The aim …

Characterization And Automated Classification Of Sentences In The Biomedical Literature: A Case Study For Biocuration Of Gene Expression And Protein Kinase Activity., Daniela Raciti, Kimberly M Van Auken, Valerio Arnaboldi, Christopher J Tabone, Hans-Michael Muller, Paul W Sternberg

Faculty Research 2025

Biological knowledgebases are essential resources for biomedical researchers, providing ready access to gene function and genomic data. Professional, manual curation of knowledgebases, however, is labour-intensive and thus high-performing machine learning (ML) methods that improve biocuration efficiency are needed. Here, we report on sentence-level classification to identify biocuration-relevant sentences in the full text of published references for two gene function data types: gene expression and protein kinase activity. We performed a detailed characterization of sentences from references in the WormBase bibliography and used this characterization to define three tasks for classifying sentences as either (i) fully curatable, (ii) fully and partially …

Prediction-Powered Inference For Clinical Trials, Pierre-Emmanuel Poulet, Maylis Tran, Sophie Tezenas Du Montcel, Bruno Dubois, Stanley Durrleman, Bruno M. Jedynak

Mathematics and Statistics Faculty Publications and Presentations

Prediction-powered inference (PPI) [1] and its subsequent development called PPI++ [2] provide a novel approach to standard statistical estimation leveraging machine learning systems to enhance unlabeled data with predictions. We use this paradigm in clinical trials. The predictions are provided by disease progression models, providing prognostic scores for all the participants as a function of baseline covariates. The proposed method would empower clinical trials by providing untreated digital twins of the treated patients while remaining statistically valid. The potential implications of this new estimator of the treatment effect in a two-arm randomized clinical trial (RCT) are manifold. First, it leads …

Niaid Workshop Report: Systematic Approaches For Eskape Bacteria Antigen Discovery, Inka Sastalla, Keehwan Kwon, Clayton Huntley, Kimberly A. Taylor Dnp, Rn, Nea-Bc, Cnor, Clssbb, Liliana Brown, Tamika Samuel, Lanling Zou

Publications

On 14-15 November 2023, the National Institute of Allergy and Infectious Diseases (NIAID) organized a workshop entitled "Systematic Approaches for ESKAPE Bacteria Antigen Discovery". The goal of the workshop was to engage scientists from diverse relevant backgrounds to explore novel technologies that can be harnessed to identify and address current roadblocks impeding advances in antigen and vaccine discoveries for the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). The workshop consisted of four sessions that addressed ESKAPE infections, antigen discovery and vaccine efforts, and new technologies including systems immunology and vaccinology approaches. Each …

Research Progress And Clinical Translation Potential Of Coronary Atherosclerosis Diagnostic Markers From A Genomic Perspective, Hanxiang Liu, Yuchen Zhang, Yueyan Zhao, Yuzhen Li, Xiaofeng Zhang, Lingyu Bao, Rongkai Yan, Yixin Yang, Huixian Zhou, Jinming Zhang, Siyuan Song

Children’s Nutrition Research Center Staff Publications

Objective: Coronary atherosclerosis (CAD) is characterized by arterial intima lipid deposition, chronic inflammation, and fibrous tissue proliferation, leading to arterial wall thickening and lumen narrowing. As the primary cause of coronary heart disease and acute coronary syndrome, CAD significantly impacts global health. Recent genetic studies have demonstrated CAD's polygenic and multifactorial nature, providing molecular insights for early diagnosis and risk assessment. This review analyzes recent advances in CAD-related genetic markers and evaluates their diagnostic potential, focusing on their applications in diagnosis and risk stratification within precision medicine.

Methods: We conducted a systematic review of CAD genomic studies from PubMed and …

Differences In Risk Appraisal And Neural Activity In Adolescents With A History Of Misconduct, Elizabeth S Escalante, Jessica S Flannery, Michael T Perino, Eva H Telzer

2020-Current year OA Pubs

While much of the prior work examining the behavioural and neural mechanisms of adolescent risk taking has focused on community samples, less is known about whether these mechanisms apply to adolescents engaging in high levels of risky behaviour. The current study examines behavioural and neural differences between adolescents with (N = 24) and without (N = 35) a history of misconduct using a risk perception questionnaire and risk-taking fMRI task. Adolescents with a history of misconduct perceived fewer negative consequences of risk relative to positive consequences and exhibited altered neural tracking of risk and reward in the nucleus accumbens. Specifically, …

Feasibility Of Ex Vivo Ligandomics, Prabuddha Waduge, Remya Ammassam Veettil, Bojun Zhang, Chengchi Huang, Hong Tian, Wei Li

Faculty, Staff and Students Publications

We developed ligandomics for the in vivo profiling of vascular ligands in mice, discovering secretogranin III (Scg3) as a novel angiogenic factor that selectively binds to retinal vessels of diabetic but not healthy mice. This discovery led to the development of anti-Scg3 therapy for ocular vasculopathies. However, in vivo ligandomics requires intracardial perfusion to remove unbound phage clones, limiting its use to vascular endothelial cells (ECs). To extend ligandomics to non-vascular cells, we investigated ex vivo ligandomics. We isolated ECs and retinal ganglion cells (RGCs) from diabetic and healthy mouse retinas by immunopanning. We quantified the binding of clonal phages …

In-Vitro Cholinesterase Inhibition Potential And Fatty Acid Profiling Of Lipids Obtained Via Direct Trans-Esterification From Sarcocephalus Latifolius (Sm.) Fruits And Leaves, Olubunmi Atolani, Joanna Adewara, Jude Onojah

Al-Bahir

Sarcocephalus latifolius (sm.) of the family, Rubiaceae, is an important plant used in folkloric medicine for the management of various disease conditions. An innovative green route was adopted for the direct characterization of the underutilized tropical plant which was profiled for the fatty acid composition and examined for the in vitro anti-cholinesterase potential. The fatty acid methyl esters obtained via direct methylation was characterized using Gas Chromatography-Mass Spectrometry, GC-FID/GC-MS. With donepezil hydrochloride as a reference, the cholinesterase enzyme inhibition capacity of the FAMEs was further assessed through standard assay. Four fatty acids were identified from the total ion chromatogram …

Mantra Meditation For Chronically Impaired Attention After Stroke: A Trial Using Single-Case Experimental Design, Cheryl Carrico, Dana Howell, John A. Patterson, Richard D. Andreatta, Camille Skubik-Peplaski

Internet Journal of Allied Health Sciences and Practice

Purpose: Impaired attention after stroke is a common problem for which rehabilitation would potentially be indicated. Systematic review evidence has revealed a lack of high-quality research that supports the effectiveness of standard-of-care cognitive rehabilitation for sustained attention, alertness, and functional impact on daily life after stroke. Standard-of-care cognitive rehabilitation does not include meditation. Meditation has been defined in contemporary scientific literature as a regime entailing voluntary self-regulation of attention. As such, meditation could potentially improve attention in keeping with tenets of neuroplasticity. The present study investigated whether mantra meditation would benefit attention for adults with chronically impaired attention after right-hemisphere …

Prevalence Of Burnout Among Doctor Of Physical Therapy Faculty, Liana Wooten, Kim Dao, Melissa Burgemeister, Angela Spontelli Gisselman

Internet Journal of Allied Health Sciences and Practice

Objective: Growing numbers of physical therapy (PT) educational programs (PTEPs) creates a challenge in recruiting and retaining faculty, potentially having negative ramifications for PT education. Burnout may be contributory as it has known physiological, psychological, and behavioral consequences in numerous clinical and academic populations, creating widespread negative outcomes. This study aimed to investigate burnout prevalence among PT faculty. Methods: Eligible participants, including current full and part-time PTEP faculty members in the United States with emails listed on public-facing program websites, were emailed study information and a link to the consent and survey. Consenting participants completed a Qualtrics survey consisting of …

Perceived Stress And Coping Mechanisms Observed In Professional Master’S Athletic Training Students, Emily Madrak, Jennifer L. Volberding, Emily Madrak

Internet Journal of Allied Health Sciences and Practice

Purpose: With the shift in level of athletic training education, studies regarding undergraduate students, especially regarding stress and coping, are quickly becoming obsolete. Because of this shift, we sought to investigate level of perceived stress (PS) in professional master’s athletic training (PMAT) students, coping skills used to mitigate PS, and what coping skills form a relationship to alter PS. We observed these variables by gender, age, year in program, and curriculum delivery model. Method: We used a quantitative cross-sectional study online survey to recruit students who were currently enrolled in a Commission on Accreditation of Athletic Training Education (CAATE) accredited …

Re-Envisioning Throwing Programs For Baseball Pitchers: A Case Report And Literature Review, S. Andrew Cage, Alexander P. Jacobsen, Clayton Hodges, Cassandra Rasmussen, Jon-Michael Cline, Brandon J. Warner, Lynzi K. Warner, Laurel Trail, Ryan Johnson, Matt Schimpf, Pauline Skowron, Robert French, Derek Lege, Nathan Campbell

Internet Journal of Allied Health Sciences and Practice

This case report follows the injury presentation and return to pitching of two NCAA Division II baseball pitchers. A literature review is provided to detail the current prevalence and epidemiology related to injuries to the throwing arm of pitchers. The review also outlines current procedures for returning a baseball pitcher to pitching from the mound. The authors discuss key concepts related to progressing previously injured pitchers back to pitching from the mound, while using the two cases presented as exemplars for using the objective, goal oriented, and adaptable interval throwing program developed at the pitchers’ university.

What’S New In Esophageal Atresia Treatment?, Alexandra N. Jimenez Gonzalez

Mako: NSU Undergraduate Student Journal

No abstract provided.

Comprehensive Overview Of Gastroschisis, Alexis Carver

Mako: NSU Undergraduate Student Journal

Gastroschisis is a congenital defect of the abdominal wall viscera that occurs during early embryonic development, leading to the protrusion of bowel through an opening near the umbilical cord. This condition is classified as either simple, involving only the bowel, or complex, involving additional complications like necrosis or intestinal atresia. While the exact cause of gastroschisis remains unknown, it is believed to be influenced by a combination of genetic and environmental factors. This congenital disorder affects a very small percentage of neonates, and the associated mortality rates are relatively low due to modern developments in medical science. Gastroschisis can be …

Retracted: Conserved Domains In Promoters Of Differentially Expressed Genes: How To Find Them And What Can They Tell Us?, Emalynn E. Tobias

Mako: NSU Undergraduate Student Journal

THIS ARTICLE HAS BEEN RETRACTED DUE TO THE FOLLOWING REASON: inadvertent errors in several citations.

The complex process of regulating gene expression involves a large number of cis- and trans-acting components. The cis elements also referred to as cis regulatory elements (CREs) are highly conserved across species, and are often referred to as conserved domains mainly located in the promoters of genes. The trans acting sequences such as enhancers, moderators and insulators are also crucial in the regulation of gene expression. With an increased influx of genomic and transcriptomic data, study of differentially expressed genes (DEGs) is highly effective in …

How Did Covid-19 Impact Physiology Research Globally? – Lessons Learned And Future Recommendations, Jeet Patel, Santanu De

Mako: NSU Undergraduate Student Journal

The Coronavirus Infectious Disease 2019 (COVID-19) pandemic caused massive changes in the medical field across the globe. As the whole world moved from in-person to remote activities, students found themselves in a predicament where they were compelled towards schooling and work online from home. This would mean that all projects, research, tests, and meetings were conducted over Zoom or other online meeting platforms. Laboratories were shut down or only a limited number of people were allowed to enter to conduct the necessary research. This paper discusses how the COVID-19 pandemic affected research process and experiments within various aspects of the …

Parallels Between Internet And Stimulant Drug Addiction, Yashica Bhuvane

Mako: NSU Undergraduate Student Journal

This analysis explores how stimulant addictions—specifically cocaine, methamphetamines, and nicotine—impact the brain's reward system, comparing these effects with those seen in Internet Addiction (IA). Drawing from functional magnetic resonance imaging (fMRI) studies, it assesses changes in key brain regions involved in reward processing, craving, and cognitive control related to these addictive behaviors. The analysis investigates how each stimulant affects dopaminergic transmission and disrupts reward circuitry, highlighting both similarities and differences in brain activation patterns linked to addiction. By comparing these patterns with those seen in IA, the analysis aims to identify which stimulant most closely resembles the neural disruptions associated …