Digital Commons Network^™

Amplifying Women's Voices In Menopause Research: The Importance Of Inclusive Perspectives, Camille Cronin, Sara Donevant Phd, Rn, Ccrn, Kerri Ann Hughes, Marja Kaunonen, Jette Marcussen, Rhonda Wilson

Publications

Menopause, a significant life transition for half the global population, intersects biological, cultural and social dimensions. Despite its universal occurrence, menopause research has historically been dominated by biomedical perspectives, often neglecting women's voices and diverse experiences. This article highlights the importance of including women's perspectives in menopause research to ensure relevance, accuracy and equity. It explores cultural variations in menopause experiences, the impact of socioeconomic status and the often-overlooked emotional and psychological dimensions. This article advocates for participatory approaches, emphasising that women's involvement enhances research design, implementation and policy development. Evidence-based interventions that are tailored to the individual can better …

Marine Protected Species Identification Guide 2025, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Occasional Publications

The Western Australian aquatic environment is home to a number of species that are protected under international agreements and national or state legislation. Many of these species occur in areas where fishing takes place, sometimes resulting in interactions between fishers and protected species. An interaction is considered to be any physical contact between a person, fishing vessel or fishing gear and a protected species, including captures, entanglements and collisions.

This guide has been developed to help you identify some common marine protected species in Western Australia that you may encounter while fishing.

It has been divided into 5 sections:

• …

Hypothyroidism Is A Risk Factor For Transient Ischemic Attack: A Meta-Analysis, Jian Li, Hui Liu, Yan Li

Saudi Medical Journal

Objectives: To evaluate whether hypothyroidism is a risk factor for transient ischemic attack (TIA). Methods: We systematically searched Embase, PubMed, Cochrane, Vipers database, China Biomedical Literature Database, Wanfang Data, and China National Knowledge Infrastructure for studies assessing the association between hypothyroidism and TIA (publication cut-off in May 2024). Two researchers independently extracted the data based on inclusion and exclusion criteria. Meta-analysis was carried out using Review Manager 5.3 software. Results: A total of 7 studies (combined n=190248) were included. Hypothyroidism showed a significant association with TIA (risk ratio [RR]=1.43 [95% confidence interval [CI]: [1.29-1.57]). The association was significant in clinical …

Neutrophil-To-Lymphocyte Ratio, Platelets-To-Lymphocyte Ratio, And Red Cell Distribution Width As Prognostic Indicators For Length Of Hospital Stay In Pediatric Asthma, Ebtihal E. Eltyeb, Gassem A. Gohal, Sami A. Alhazmi, Mohammed A. Alqassim, Ehab F. Hakami, Mnar H. Moafa, Najla H. Mutahar, Maisaa M. Shanaq, Sara M. Shanaq, Abdullah J. Almalki, Asmaa A. Jabrah, Shorouq A. Mashhour, Ali A. Dagreri, Rahaf S. Othathi, Siddig Ibrahim Abdelwahab

Saudi Medical Journal

Objectives: To examine the relationship between neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte ratio (PLR), and red cell distribution width (RDW) and the length of hospital stay (LOS) in children with bronchial asthma Methods: This hospital-based study examined the records of children with asthma admitted to Jazan Hospitals, Jazan, Kingdom of Saudi Arabia. Data were extracted at the time of admission. Length of hospital stay and laboratory parameters were acquired from blood. Results: This study involved 489 children, with a mean age of 5.8±3.5 years, of which 59.7% were male. Notably, 77.7% of the patients resided in rural areas of Jazan. The mean …

Customary Corruption, Ani B. Satz, Liza Vertinsky

William & Mary Law Review

For over a hundred years, it has been well-accepted among tort scholars that physicians—as one of the legally recognized professions— determine their own customary practices. Within tort law, and medical malpractice more specifically, customary practice establishes whether physicians breach or uphold the required standard of care toward their patients. The results of our hand-coded examination of decided cases and statutes show a more complex picture. While some states have endeavored to shift the standard away from professional custom, it continues to play a critical, and in many cases a determinative, role in establishing physician liability in most states.

Using illustrative …

Curriculum Preferences And Engagement Of Online Entrepreneurship Students: The Influence Of Age And Gender, S. Andrew Starbird, Jill M. Martin, Trish A. Kalbas-Schmidt

Information Systems and Analytics

It is important for instructors and institutions to create learning experiences that are engaging, effective, and meaningful for students. To achieve these goals, instructors must understand the preferences and interests of their students, build engaging lessons based on those interests, and mitigate content that might make students feel excluded. In-person learning allows instructors to gather information about interests and engagement through direct interaction with students. Gathering information about student interests and engagement is more difficult for asynchronous, self-paced, online training programs. In this paper, we assess the interests, engagement, and disengagement of learners accessing online content focused on entrepreneurship. We …

The Built Environment And Place Attachment: Insights From Japanese Cities, Juiling Li, Mohammed Javad Koohsari, Andrew T. Kaczynski, Ryo Tanimoto, Reo Watanabe, Tomoki Nakaya, Yufeng Luo, Jing Zhao, Akitomo Yasunaga, Koichiro Oka, Tomoya Hanibuchi

Faculty Publications

Objective

Methods

Results

Multi-Cancer Early Detection Tests: Attributes For Clinical Implementation, Jon O. Ebbert, Ernest T. Hawk, Christopher V. Chambers, Margaret A. Tempero, Elliot K. Fishman, Jospeh E. Ravenell, Tomasz M. Beer, Seema P. Rego

Department of Family & Community Medicine Faculty Papers

Guideline-recommended screening programs exist for only a few single-cancer types, and these cancers represent less than one-half of all new cancer cases diagnosed each year in the U.S. In addition, these "single-cancer" standard of care (SoC) screening tests vary in accuracy, adherence, and effectiveness, though all are generally understood to lead to reductions in cancer-related mortality. Recent advances in high-throughput technologies and machine learning have facilitated the development of blood-based multi-cancer early detection (MCED) tests. The opportunity for early detection of multiple cancers with a single blood test holds promise in addressing the current unmet need in cancer screening. By …

Cueing Motions In A String Quartet, An Exploratory Study Of Motion Trajectories, Maren Rothfritz

Dissertations, Theses, and Capstone Projects

A string quartet performance involves an array of different body movements which serve many functions, including sound production, expression, and communication. This dissertation examines the ways string quartet players execute specific communicative body motions called cues, which are anticipatory gestures meant to communicate tempo and timing as well as the musical intentions such as dynamics, articulation, and character to the co-performers. Some scholarly research exists on cueing, but a formalized description of the cueing motions involved has not yet been developed. This dissertation serves as an exploratory study examining the motion trajectories of cueing motions employed by the Argus Quartet, …

Notch3 Deletion Regulates Hiv-1 Gene Expression And Systemic Inflammation To Ameliorate Chronic Kidney Disease, Mackenzie Thornton, Nicole Sommer, Mercedes Mcgonigle, Anil Kumar Ram, Sireesha Yerrathota, Henrietta Ehirim, Aakriti Chaturvedi, Johnny Dinh Phan, Anubhav Chakraborty, V. Praveen Chakravarthi, Sumedha Gunewardena, Mudit Tyagi, Jaya Talreja, Tao Wang, Pravin Singhal, Pamela V. Tran, Timothy A. Fields, Patricio E. Ray, Navneet K. Dhillon, Madhulika Sharma

Center for Translational Medicine Faculty Papers

Anti-retroviral therapy (ART) has decreased human immunodeficiency virus (HIV)-1-associated morbidity. However, despite ART, immune cells remain latently infected, leading to chronic inflammation and HIV-1-associated comorbidities. New strategies are needed to target viral proteins and inflammation. We found activation of Notch3 in renal cells of the HIV-1 transgenic mouse model (HIV-Tg26) and in patients with HIV-associated nephropathy. We hypothesized that targeting NOTCH3 activation constitutes an effective therapy for HIV-related chronic kidney disease. We generated HIV-Tg26 mice with Notch3 knocked out (Tg-N3KO). Compared to HIV-Tg26 mice at 3 months, Tg-N3KO mice showed a marked reduction in renal injury, skin lesions and mortality …

Investigating The Risk And Protective Factors Of Internet Addiction Among Adolescents Through The Lens Of Cognitive Behavioral Theory: A Cross-Sectional Study, Noura Shaltout

Theses and Dissertations

—Introduction: The Internet has become a central part of modern life, enhancing education, providing means of global communication, and facilitating access to information and entertainment. However, an attendant risk of excessive Internet use is becoming unconsciously addicted to virtual online activities, especially when large tech companies design their products in a way that makes them addictive to users. These companies have the tools and knowledge that allow them to manipulate and transform the behavior of their target audience. Thus, this study aimed to investigate the potential risk and protective factors for Internet addiction among adolescents. Methodology: This cross-sectional study employed …

Gdp-Mannose 4,6-Dehydratase Is A Key Driver Of Mycn-Amplified Neuroblastoma Core Fucosylation And Tumorigenesis, Beibei Zhu, Michelle G. Pitts, Michael D. Buoncristiani, Lindsay T. Bryant, Oscar Lopez-Nunez, Juan P. Gurria, Cameron Shedlock, Roberto Ribas, Shannon Keohane, Jinpeng Liu, Chi Wang, Matthew S. Gentry, Nathan R. Shelman, Derek B. Allison, B. Mark Evers, Ramon C. Sun, Eric J. Rellinger

Markey Cancer Center Faculty Publications

MYCN-amplification is a genetic hallmark of ~40% of high-risk neuroblastomas (NBs). Altered glycosylation is a common feature of adult cancer progression, but little is known about how genetic signatures such as MYCN-amplification alter glycosylation profiles. Herein, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased core fucosylated glycan abundance within neuroblast-rich regions of human MYCN-amplified NB tumors. GDP-mannose 4,6-dehydratase (GMDS) is responsible for the first-committed and rate-limiting step of de novo GDP-fucose synthesis. High GMDS expression was found to be associated with poor patient survival, advanced stage disease, and MYCN-amplification in human NB tumors. Chromatin immunoprecipitation and promoter reporter assays …

A Microrna-Regulated Transcriptional State Defines Intratumoral Cd8+ T Cells That Respond To Immunotherapy, William W. Tang, Ben Battistone, Kaylyn M. Bauer, Allison M. Weis, Cindy Barba, Muhammad Zaki Hidayatullah Fadlullah, Arevik Ghazaryan, Van B. Tran, Soh-Hyun Lee, Z. Busra Agir, Morgan C. Nelson, Emmanuel Stephen Victor, Amber Thibeaux, Colton Hernandez, Jacob Tantalla, Aik C. Tan, Dinesh Rao, Matthew Williams, Micah J. Drummond, Ellen J. Beswick, June L. Round, H. Atakan Ekiz, Warren P/ Voth, Ryan M. O’Connell

Markey Cancer Center Faculty Publications

The rising incidence of advanced-stage colorectal cancer (CRC) and poor survival outcomes necessitate new and effective therapies. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 therapy, show promise, yet clinical determinants of a positive response are suboptimal. Here, we identify microRNA-155 (miR-155) as necessary for CD8 + T cell-infiltrated tumors through an unbiased in vivo CRISPR-Cas9 screen identifying functional tumor antigen-specific CD8+ T cell-expressed microRNAs. T cell miR-155 is required for anti-PD-1 responses and for a vital intratumor CD8 + T cell differentiation cascade by repressing Ship-1, inhibiting Tcf-1 and stemness, and subsequently enhancing Cxcr6 expression, anti-tumor immunity, and effector functions. Based …

Staying Sane In The Membrane: Neutral Sphingomyelinase 2 As A Master Regulator Of Plasma Membrane Ceramide, Zainuddin Quadri, Erhard Bieberich

Markey Cancer Center Faculty Publications

Ceramide, a key signaling sphingolipid in the plasma membrane, plays a pivotal role in fundamental cellular processes such as adhesion, polarity, and programmed cell death. The generation of plasma membrane ceramide is largely attributed to the activity of two types of sphingomyelinases: neutral sphingomyelinase 2 (nSMase2, Smpd3) and acid sphingomyelinase (aSMase, Smpd1). While many studies have explored ceramide generation following experimental activation of these enzymes, the mechanisms governing basal or steady- state ceramide levels have remained poorly understood. Using an innovative mass spectrometry approach developed in the Canals’ lab, the team has quantified the distinct contributions of nSMase2 and aSMase …

The Mitochondria As An Emerging Target Of Self- Renewal In T-Cell Acute Lymphoblastic Leukemia, Majd Al-Hamaly, Evelyn Winter, Jessica S. Blackburn

Markey Cancer Center Faculty Publications

Acute lymphocytic leukemia (ALL) is the most common leukemia in children, with the T-cell subtype (T- ALL) accounting for 15% of those cases. Despite advancements in the treatment of T-ALL, patients still face a dismal prognosis following their first relapse. Relapse can be attributed to the inability of chemotherapy agents to eradicate leukemia stem cells (LSC), which possess self-renewal capabilities and are responsible for the long-term maintenance of the disease. Mitochondria have been recognized as a therapeutic vulnerability for cancer stem cells, including LSCs. Mitocans have shown promise in T-ALL both in vitro and in vivo, with some currently in …

Gdp-Mannose 4,6-Dehydratase Is A Key Driver Of Mycn- Amplified Neuroblastoma Core Fucosylation And Tumorigenesis, Beibei Zhu, Michelle G. Pitts, Michael D. Buoncristiani, Lindsay T. Bryant, Oscar Lopez-Nunez, Juan P. Gurria, Cameron Shedlock, Roberto Ribas, Shannon Keohane, Jinpeng Liu, Chi Wang, Matthew S. Gentry, Nathan R. Shelman, Derek B. Allison, B. Mark Evers, Ramon C. Sun, Eric J. Rellinger

Markey Cancer Center Faculty Publications

MYCN-amplification is a genetic hallmark of ~40% of high-risk neuroblastomas (NBs). Altered glycosylation is a common feature of adult cancer progression, but little is known about how genetic signatures such as MYCN-amplification alter glycosylation profiles. Herein, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased core fucosylated glycan abundance within neuroblast-rich regions of human MYCN-amplified NB tumors. GDP-mannose 4,6-dehydratase (GMDS) is responsible for the first-committed and rate-limiting step of de novo GDP-fucose synthesis. High GMDS expression was found to be associated with poor patient survival, advanced stage disease, and MYCN-amplification in human NB tumors. Chromatin immunoprecipitation and promoter reporter assays …

Tracking Community Outreach And Engagement Activities Among National Cancer Institute-Designated Cancer Centers, Todd Burus, Caree Mcafee, Pamela Hull, Amy Leader, Christopher Mcnair

Kimmel Cancer Center Faculty Papers

The National Cancer Institute's (NCI) Cancer Center Support Grant mandates that NCI-designated cancer centers establish a Community Outreach and Engagement (COE) component to help direct efforts at reducing cancer burden within their catchment areas. Despite the critical role of COE offices, little is known about how they track and evaluate outreach activities and outcomes. We gathered information on current practices from representatives of 40 out of 65 COE offices using an online survey. Although nearly all responding centers (97.5%) tracked COE activities, no consensus existed on resources used, and satisfaction with current solutions was mixed (51.0% not satisfied). Respondents expressed …

Association Between Factor I Fibrinogen (Rs6050) And Factor Xi Plasma Thromboplastin (Rs4253417) Genetic Polymorphisms And Recurrent Spontaneous Miscarriage In Saudi Women, Aaishah M. Kaabi, Afrah F. Alkhuriji, Zeneb A. Babay, Ibrahim A. Barakat, Abdullah M. Kaabi, Reem M. Kaabi

Saudi Medical Journal

Objectives: To identify genetic polymorphisms in factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) in Saudi women with recurrent spontaneous miscarriage (RSM). Furthermore, to compare the levels of clotting factors in the blood of patients and healthy controls. Methods: The current study was conducted at the King Khalid University Hospital in Riyadh, Saudi Arabia, from September 2022 to June 2023. The study involved 100 Saudi women, 50 pregnant and 50 non-pregnant individuals, who experienced RSM. Furthermore, 100 healthy Saudi women, including 50 pregnant and 50 non-pregnant individuals, were also included as controls. TaqMan genotyping assays were used to …

Risk Factors For Depression Symptoms In Adolescents: A Population-Based Study, Dewinda Candrarukmi, Fitri Hartanto, Tunjung Wibowo, Hari W. Nugroho, Moh S. Anam, Braghmandita W. Indraswari, Qodri Santosa, Nazliah Hanum

Saudi Medical Journal

Objectives: To ascertain the prevalence of depressive symptoms and identify related risk factors among adolescents. Methods: A cross-sectional survey was carried out using an online questionnaire completed by 1,413 adolescents from Central Java and Yogyakarta Provinces، Indonesia. The validated Indonesian version of the Children’s Depression Inventory (CDI) was used to evaluate depressive symptoms. Results: Symptoms of depression were identified in 28.5% of participants. Multivariate analysis revealed important risk factors, including female gender (OR 3.962, 95% CI 2.684–5.849), having mother who is a housewife (OR 4.155, 95% CI 1.424–12.126) or works in labor/farming/self-employment (OR 3.665, 95% CI 1.216–11.051), residing with a …

A Qualitative Analysis Of Awareness And Perceptions Of African Immigrant Men Regarding Hpv Vaccine Uptake In Children To Prevent Cervical Cancer, Netsai Nancy Mariga Andere

Walden Dissertations and Doctoral Studies

Low Human Papillomavirus (HPV) vaccine acceptance remains one of the most crucial disparities in the US by country of origin among children. The study aims to qualitatively explore the HPV and HPV vaccine awareness and perceptions among African immigrant men to help reduce the HPV-related cervical cancer burden among African immigrants living in the US. The health belief model (HBM) was used for this basic qualitative study of self-reported awareness and perception among African immigrant men in the US with responses from 11 individual interviews. Thematic analysis was utilized to analyze the data collected from the interview responses. Six themes …

Risk Factors For Peripheral Artery Disease-Related Amputations Among Black Americans, Darnell L. Blake

Walden Dissertations and Doctoral Studies

Evidence suggests that Black Americans (BAs) are at a significantly higher risk of peripheral artery disease (PAD)-related amputations. This study aimed to examine risk factors for non-traumatic lower extremity amputation (NTLEA) among BAs with PAD addressing a significant knowledge gap regarding racial disparities in PAD outcomes. Grounded in Bandura's social cognitive theory, which posits the interplay among personal factors, environmental influences, and behavior, this study examines how age, gender, income, and comorbidities like cardiovascular disease, kidney disease, and diabetes influence NTLEA across various insurance types (private, Medicaid, Medicare, self-pay). This quantitative cross-sectional study used the 2020 National Inpatient Sample, 1% …

A Qualitative Analysis Of Awareness And Perceptions Of African Immigrant Men Regarding Hpv Vaccine Uptake In Children To Prevent Cervical Cancer, Netsai Nancy Mariga Andere

Walden Dissertations and Doctoral Studies

Low Human Papillomavirus (HPV) vaccine acceptance remains one of the most crucial disparities in the US by country of origin among children. The study aims to qualitatively explore the HPV and HPV vaccine awareness and perceptions among African immigrant men to help reduce the HPV-related cervical cancer burden among African immigrants living in the US. The health belief model (HBM) was used for this basic qualitative study of self-reported awareness and perception among African immigrant men in the US with responses from 11 individual interviews. Thematic analysis was utilized to analyze the data collected from the interview responses. Six themes …

Risk Factors For Peripheral Artery Disease-Related Amputations Among Black Americans, Darnell L. Blake

Walden Dissertations and Doctoral Studies

Evidence suggests that Black Americans (BAs) are at a significantly higher risk of peripheral artery disease (PAD)-related amputations. This study aimed to examine risk factors for non-traumatic lower extremity amputation (NTLEA) among BAs with PAD addressing a significant knowledge gap regarding racial disparities in PAD outcomes. Grounded in Bandura's social cognitive theory, which posits the interplay among personal factors, environmental influences, and behavior, this study examines how age, gender, income, and comorbidities like cardiovascular disease, kidney disease, and diabetes influence NTLEA across various insurance types (private, Medicaid, Medicare, self-pay). This quantitative cross-sectional study used the 2020 National Inpatient Sample, 1% …

The Impact Of Working With Forced Migrants In The Context Of Graduate Research Training, Alfonso Mercado, Frances R. Morales, Amanda Palomin, Andy U. Torres, Amanda Venta

Psychological Science Faculty Publications

Researchers, including graduate students, who work with refugees and asylum seekers are exposed to narratives of torture, trauma, loss, and distress. This article features the testimonies of the authors as doctoral students and mental health researchers-in-training—as well as their supervisors—regarding their research with the immigrant community in an underserved area on the Texas U.S.–Mexico border, a popular migratory entry point for Central American immigrants seeking asylum in the United States. This article aimed to bear witness to the emotional impact that working with forced migrants may have on researchers by describing the experiences of doctoral students conducting research with asylum …

Fors 481.02: Forest Planning, Elizabeth M. Dodson

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Ahst 101.01: Introduction To Surgical Technology, Katherine E. Geiger

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Bioh 105n.H50: Basic Human Biology Laboratory - Hamilton, Eric Gren

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Slp 640.B01: Swallowing Disorders, Trudi F. Mingus

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Slp 640.V50: Swallowing Disorders, Trudi F. Mingus

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Csci 477.01: Simulation, Jesse V. Johnson

University of Montana Course Syllabi, 2021-2025

No abstract provided.