Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2025

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 23761 - 23790 of 31522

Full-Text Articles in Entire DC Network

Black English For Lawyers: A Primer, L. Alexander Walker Iii Feb 2025

Black English For Lawyers: A Primer, L. Alexander Walker Iii

Faculty Scholarship

Lawyers do not know as much about Black English as they should, and people’s freedom hangs in the balance. Differences between language varieties in sounds and grammar can change and have changed the outcome of cases: “He at work” and “He be at work” mean two completely different things. To reduce misinterpretation and therefore wrongful outcomes, this Article provides a primer on the sounds, words, grammar, and social context of Black English targeted directly at legal practitioners. It begins by explaining key concepts in linguistics and making the case for why lawyers must foreground accurate description over normative prescription when …


Watershed Land Use Decreases The Nitrogen Limitation Of Benthic Algal Growth In Coastal Wetlands Of A Large Oligotrophic Lake, Matthew J. Cooper, Michele C. Wheeler Feb 2025

Watershed Land Use Decreases The Nitrogen Limitation Of Benthic Algal Growth In Coastal Wetlands Of A Large Oligotrophic Lake, Matthew J. Cooper, Michele C. Wheeler

Open Access Publishing Support Funded Articles

Introduction:

Identifying patterns in the primary limiting nutrients of basal trophic levels such as benthic algae can inform the prediction of potential ecological responses to anthropogenic nutrient loading. In coastal wetlands of the Laurentian Great Lakes, reduced concentrations of reactive nitrogen species such as ammonium and nitrate may limit algal growth, especially when nutrient loading is minimal. However, the response of benthic algae to macronutrient inputs remains understudied, especially in Lake Superior coastal wetlands.

Methods:

We conducted nutrient amendment assays using nutrient diffusing substrate devices in 25 coastal wetlands along the southwestern shore of Lake Superior in the spring, summer, …


Product Testing: Research Shows Benefits Of Biostimulants May Vary By Variety, Prakriti Nepal, Youping Sun, Milena Oliveira Feb 2025

Product Testing: Research Shows Benefits Of Biostimulants May Vary By Variety, Prakriti Nepal, Youping Sun, Milena Oliveira

Plants, Soils and Climate Student Research

The use of plant biostimulants is showing some promise as a potential means of helping onion crops thrive despite certain environmental challenges, according to new research at Utah State University.


Racial Powers, Talhah Mustafa Feb 2025

Racial Powers, Talhah Mustafa

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation will be divided into three papers that in some way considers the concept of racial powers. The concept of racial power is under-researched and presupposed in the Philosophy of Race literature. Many arguments in this field seem premature without a general understanding of racial powers. The first paper fills that gap by introducing and defending the view that racial powers are possessed in virtue of one’s race or perceived race.

In the second paper, I consider Chike Jeffers’ cultural constructionist account of race. The nature of race is complex, requiring nuanced consideration. Chike Jeffers’ cultural constructionist may seem …


The Enlightenment In Early America, Annette Gordon-Reed Feb 2025

The Enlightenment In Early America, Annette Gordon-Reed

William & Mary Law Review

The founding of the United States of America is often said to have been the product of Enlightenment ideals that emphasized reason, individual liberty, and notions of progress. During this same era, however, racially based slavery, which confounded reason, denied individual liberty to millions, and challenged ideas about progress, existed in all of the colonies of North America.

The third president of the United States, Thomas Jefferson, embodied this seeming contradiction at the heart of the American founding. The principal author of the American Declaration of Independence enslaved hundreds of people over the course of his long life.

This Article …


The Rise Of China And The Concept Of Civilization: Constructing A Conceptual Apparatus For Cross-Civilizational Comparisons, Liah Greenfeld Feb 2025

The Rise Of China And The Concept Of Civilization: Constructing A Conceptual Apparatus For Cross-Civilizational Comparisons, Liah Greenfeld

Comparative Civilizations Review

The Rise of China and the Concept of Civilization: Constructing a Conceptual Apparatus for Cross-Civilizational Comparisons

The paper examines the deficiencies of the current understanding of “civilization” in the social science literature, among others exemplified by “civilizational analysis,” and proposes a new concept that adds to the conceptual apparatus of sociological theory — a new, fully independent of others, variant of the cultural process. This independence makes distinctions between civilizations as the root cause of socio-cultural diversity.

Combined with the idea of humanity as a culturally constituted reality sui generis, this concept allows the construction of the theoretical scaffolding …


Jane Goodall’S Integration Of Science And Spirituality, Estella Elpers Feb 2025

Jane Goodall’S Integration Of Science And Spirituality, Estella Elpers

Father Jack McGrath, S.M., Research Award Presentations

Estella Elpers is a recipient of the Father Jack McGrath, S.M., Award for Research in Catholic Intellectual Traditions.


Examining The Role Of Executive Functioning In Self-Care Of Type 1 Diabetes Among Youth, Erin Vogel Feb 2025

Examining The Role Of Executive Functioning In Self-Care Of Type 1 Diabetes Among Youth, Erin Vogel

Doctor of Psychology (PsyD)

This study explores the relationships between youth executive functioning, symptoms of depression, the self-management (self-care) of Type 1 diabetes (T1D), and glycemic control, a proxy for diabetes-related health outcomes. Utilizing archival clinical data from a universityaffiliated pediatric diabetes clinic, the study tested a priori hypothesized associations between depressive symptoms, executive functioning, diabetes self-care, and health outcomes. Parent and youth measures included the Patient Health Questionnaire-9 to assess youth depression, the Diabetes Related Executive Functioning Scale-Short Form to assess youth executive functioning, and the Diabetes Self-Management Profile-Short Form to assess youth diabetes-related self-care behaviors. Hemoglobin A1c (HbA1c) assays were a secondary …


Emapalumab Treatment In Patients With Rheumatologic Disease-Associated Hemophagocytic Lymphohistiocytosis In The United States: A Retrospective Medical Chart Review Study., Shanmuganathan Chandrakasan, Carl E. Allen, Deepika Bhatla, John Carter, May Chien, Robert Cooper, Lauren Draper, Olive S. Eckstein, Rabi Hanna, J Allyson Hays, Michelle L. Hermiston, Ashley P. Hinson, Patricia M. Hobday, Michael S. Isakoff, Michael B. Jordan, Jennifer W. Leiding, Renee Modica, Taizo A. Nakano, Abiola Oladapo, Sachit A. Patel, Priti Pednekar, Mona Riskalla, Susmita N. Sarangi, Prakash Satwani, Anand Tandra, Kelly J. Walkovich, John D. Yee, Adi Zoref-Lorenz, Edward M. Behrens, Real‐Hlh Investigators Feb 2025

Emapalumab Treatment In Patients With Rheumatologic Disease-Associated Hemophagocytic Lymphohistiocytosis In The United States: A Retrospective Medical Chart Review Study., Shanmuganathan Chandrakasan, Carl E. Allen, Deepika Bhatla, John Carter, May Chien, Robert Cooper, Lauren Draper, Olive S. Eckstein, Rabi Hanna, J Allyson Hays, Michelle L. Hermiston, Ashley P. Hinson, Patricia M. Hobday, Michael S. Isakoff, Michael B. Jordan, Jennifer W. Leiding, Renee Modica, Taizo A. Nakano, Abiola Oladapo, Sachit A. Patel, Priti Pednekar, Mona Riskalla, Susmita N. Sarangi, Prakash Satwani, Anand Tandra, Kelly J. Walkovich, John D. Yee, Adi Zoref-Lorenz, Edward M. Behrens, Real‐Hlh Investigators

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Rheumatologic disease-associated hemophagocytic lymphohistiocytosis (HLH), a rare, life-threatening, systemic hyperinflammatory syndrome, occurs as a complication of underlying rheumatologic disease. Real-world evidence is lacking on emapalumab, a fully human monoclonal antibody that neutralizes the proinflammatory cytokine interferon-γ, approved for treating patients with primary HLH.

METHODS: REAL-HLH, a retrospective medical chart review study conducted across 33 US hospitals, assessed real-world treatment patterns and outcomes in patients with HLH treated with one or more dose of emapalumab between November 20, 2018, and October 31, 2021. Data are presented for the subset of patients with rheumatologic disease-associated HLH.

RESULTS: Fifteen of 105 patients …


Rapid And Scalable Personalized Aso Screening In Patient-Derived Organoids., John C. Means, Anabel L. Martinez-Bengochea, Daniel A. Louiselle, Jacqelyn Nemechek, John M. Perry, Emily G. Farrow, Tomi Pastinen, Scott T. Younger Feb 2025

Rapid And Scalable Personalized Aso Screening In Patient-Derived Organoids., John C. Means, Anabel L. Martinez-Bengochea, Daniel A. Louiselle, Jacqelyn Nemechek, John M. Perry, Emily G. Farrow, Tomi Pastinen, Scott T. Younger

Manuscripts, Articles, Book Chapters and Other Papers

Personalized antisense oligonucleotides (ASOs) have achieved positive results in the treatment of rare genetic disease. As clinical sequencing technologies continue to advance, the ability to identify patients with rare disease harbouring pathogenic genetic variants amenable to this therapeutic strategy will probably improve. Here we describe a scalable platform for generating patient-derived cellular models and demonstrate that these personalized models can be used for preclinical evaluation of patient-specific ASOs. We describe protocols for delivery of ASOs to patient-derived organoid models and confirm reversal of disease-associated phenotypes in cardiac organoids derived from a patient with Duchenne muscular dystrophy (DMD) with a structural …


Effects Of Ischemic Conditioning On Microvascular Reactivity To Single Passive Limb Movement In Young Adults: A Pilot Study, Alicen A. Whitaker-Hilbig, Jennifer N. Nguyen, Amanda E. Wietrzny, Gabriel R. Merkow, Sergey Tarima, Emilie A. Klevenow, Luke Nelson, Allison S. Hyngstrom, Matthew J. Durand Feb 2025

Effects Of Ischemic Conditioning On Microvascular Reactivity To Single Passive Limb Movement In Young Adults: A Pilot Study, Alicen A. Whitaker-Hilbig, Jennifer N. Nguyen, Amanda E. Wietrzny, Gabriel R. Merkow, Sergey Tarima, Emilie A. Klevenow, Luke Nelson, Allison S. Hyngstrom, Matthew J. Durand

Physical Therapy Faculty Research and Publications

Purpose

Single passive limb movement (sPLM) of the lower extremity is a simple and clinically relevant measure of the microvascular vasodilatory response to movement. A promising stimulus to improve microvascular health is ischemic conditioning (IC). We examined whether a single session of IC could improve microvascular reactivity to sPLM in young adults.

Methods

This was a blinded, crossover, randomized clinical trial. Participants were seated in an isokinetic dynamometer that passively moved the knee 90° at a frequency of 1 Hz while superficial femoral artery leg blood flow (LBF) was measured. The absolute and the relative peak changes in LBF were …


Environmental-Health Convergence: A Deep Learning-Oriented Decision Support System For Catalyzing Sustainable Healthy Food Systems, Prince Agyemang, Ebenezer M. Kwofie, Jamie I. Baum, Dongyi Wang, Emmanuel A. Kwofie Feb 2025

Environmental-Health Convergence: A Deep Learning-Oriented Decision Support System For Catalyzing Sustainable Healthy Food Systems, Prince Agyemang, Ebenezer M. Kwofie, Jamie I. Baum, Dongyi Wang, Emmanuel A. Kwofie

Biological and Agricultural Engineering Faculty Publications and Presentations

To generate evidence to address food system challenges, we developed an adaptable framework for multimodel assessment of the convergence effect of health and environmental drivers in food systems. We achieved this goal by developing a modeling framework that facilitates testing and applying four deep-learning algorithms using a case study of the United States's food system. Among the models tested, the bidirectional and single-layer long short-term memory models outperformed the others with αE(2.75) and αH(3.51) when predicting environmental drivers and health drivers, respectively. All the models tested performed better at predicting environmental than health drivers. The best-performing …


2025 February, Morehead State University. Office Of Communications & Marketing. Feb 2025

2025 February, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for February of 2025.


Palovarotene In Fibrodysplasia Ossificans Progressiva: Review And Perspective, Vincent Verheij, Robert Diecidue, Esmée Botman, Joseph Harrington, Nobuhiko Haga, Alberto Hidalgo-Bravo, Patricia Delai, Vrisha Madhuri, Mona Al Mukaddam, Keqin Zhang, Tae-Joon Cho, Rolf Morhart, Richard Keen, Carmen De Cunto, Clive Friedman, Zvi Grunwald, Michael Zasloff, J. Coen Netelenbos, Edward Hsiao, Frederick Kaplan, Robert Pignolo, Christiaan Scott, Elisabeth Marelise Eekhoff Feb 2025

Palovarotene In Fibrodysplasia Ossificans Progressiva: Review And Perspective, Vincent Verheij, Robert Diecidue, Esmée Botman, Joseph Harrington, Nobuhiko Haga, Alberto Hidalgo-Bravo, Patricia Delai, Vrisha Madhuri, Mona Al Mukaddam, Keqin Zhang, Tae-Joon Cho, Rolf Morhart, Richard Keen, Carmen De Cunto, Clive Friedman, Zvi Grunwald, Michael Zasloff, J. Coen Netelenbos, Edward Hsiao, Frederick Kaplan, Robert Pignolo, Christiaan Scott, Elisabeth Marelise Eekhoff

Department of Oral and Maxillofacial Surgery Faculty Papers

INTRODUCTION: Palovarotene is a retinoic acid receptor gamma agonist that was studied in phase-2 and phase-3 clinical trials for the inhibition of new heterotopic ossification (HO) in fibrodysplasia ossificans progressiva (FOP). Despite numerous setbacks and regulatory delays, palovarotene is now the first approved FOP treatment in the U.S.A., Canada and Australia but remains unapproved in Europe where concerns surrounding the drug and its path to regional market authorization persist.

AREAS COVERED: The developmental history of palovarotene and an overview of the clinical trials and the regulatory approval journey are discussed by global FOP experts.

EXPERT OPINION: While post hoc analyses …


Optimization Of Localized Photothermal Therapy Utilizing Liposomal Formulation Of Ir-820 Photoactive Dye, Dinesh Shrestha, Viswanathan Sundaram, Shoukath Sulthana, Danyel Manteufel, Shelby Metcalf, Santosh Aryal Feb 2025

Optimization Of Localized Photothermal Therapy Utilizing Liposomal Formulation Of Ir-820 Photoactive Dye, Dinesh Shrestha, Viswanathan Sundaram, Shoukath Sulthana, Danyel Manteufel, Shelby Metcalf, Santosh Aryal

Pharmacy Faculty Publications and Presentations

Current phototherapeutic approaches in cancer treatment include photothermal (PTT) and photodynamic (PDT) therapy, which harness light energy for the activation of a photoactive molecule resulting in the destruction of cancer cells. In PTT, generated local heat kills abnormal cells; whereas, in PDT, a series of biochemical reactions generating reactive oxygen species is responsible for cellular damage. However, a major concern arises in the cellular delivery of an optimal amount of a photoactive molecule required for the desired effect. In this work, we employed IR-820, a new Indocyanine green dye, in a liposomal formulation to maximize its delivery to cancer cells …


Litigating Predator Management, John A. Erwin Feb 2025

Litigating Predator Management, John A. Erwin

Utah Law Review

Despite significant gains over the last half-century, predators such as mountain lions, wolves, and bears are in the crosshairs once again. Scientific management, democratic principles, and the holding of wildlife resources in trust for the public are all foundational pillars of the North American Model for Wildlife Conservation, yet state wildlife agencies and legislatures routinely fail to uphold these values where predators are concerned. Many of these tensions were thrust into the public consciousness in 2020 when gray wolves were temporarily delisted under the Endangered Species Act (ESA), resulting in a disastrous wolf hunting season in Wisconsin. States that have …


Economic Impact Of Energy Accounting Schemes For Commercial Systems On A Broiler Farm With Power Demand And Generation, Yi Liang, Michael Popp Feb 2025

Economic Impact Of Energy Accounting Schemes For Commercial Systems On A Broiler Farm With Power Demand And Generation, Yi Liang, Michael Popp

Biological and Agricultural Engineering Faculty Publications and Presentations

The aim of this study was to assess the impact of the on-farm solar photovoltaic (PV) generation to offset grid electricity consumption on a commercial poultry farm in the US. Hourly electricity production by PV systems was estimated using the System Advisor Model (SAM) of the National Renewable Energy Lab (NREL) and compared with the estimated electric load demand of a broiler house. We analyzed the economic benefits of installing solar systems of three capacities under net energy metering and net energy billing pricing scenarios. Results suggested that a smaller PV installation of 35 kWp, while substantially short of meeting …


Assessing Vegetation Changes And Ecosystem Impacts Of Invasive Species In Florida's Water Conservation Area 3a (2004–2024) Using Landsat Data, Gideon Tandoh Feb 2025

Assessing Vegetation Changes And Ecosystem Impacts Of Invasive Species In Florida's Water Conservation Area 3a (2004–2024) Using Landsat Data, Gideon Tandoh

Research, Papers & Creative Work

The spread of invasive species is a concrete problem, threatening biodiversity, ecosystem integrity, and the functional status of wetlands. As these species continue to advance, it is crucial to assess their spread as well as management success through the more sophisticated invasive monitoring methodologies. This research examines the change in vegetation communities and the spread of invasive plants in the Water Conservation Area 3A (WCA-3A) using Object-Based Image Analysis (OBIA) and Support Vector Machine (SVM) classifiers on time series Landsat images. Unlike traditional pixel-based methods, OBIA enhances classification accuracy by incorporating spatial, spectral, and contextual information, enabling precise differentiation between …


Ischemia/Reperfusion Injury Enhances Accumulation Of Perfluoropropane Droplets, C. Chen, S. Li, T. O. Matsunaga, E. Carr Everbach, F. Xie, T. R. Porter, F. S. Villanueva, X. Chen Feb 2025

Ischemia/Reperfusion Injury Enhances Accumulation Of Perfluoropropane Droplets, C. Chen, S. Li, T. O. Matsunaga, E. Carr Everbach, F. Xie, T. R. Porter, F. S. Villanueva, X. Chen

Engineering Faculty Works

Objective: Perfluoropropane droplets (PD) are nanometer-sized particles that can be formulated from commercially available contrast agents. The preferential retention of PDs in diseased microvascular beds can be detected by ultrasound imaging techniques after acoustic activation and offers an opportunity for the detection of such processes as scar formation or inflammation. We hypothesized that in the presence of ischemia/reperfusion (I/R) injury, retention of intravenously injected PDs would be enhanced. Methods: Using an established intravital microscopy model of rat cremaster microcirculation, we determined the retention and subsequent acoustic activation behavior of PDs in exteriorized rat cremaster tissue. DiI-labeled droplets (200 µL) were …


Extracellular Vesicles Released By All Patients Contain Hne-Adducted Proteins: Implications Of Collateral Damage., Jenni Ho, Suriyan Sukati, Tamara Taylor, Sherry Carter, Brittany Fuller, Amy Marmo, Caryn Sorge, John D'Orazio, D Allan Butterfield, Subbarao Bondada, Heidi Weiss, Daret K St Clair, Luksana Chaiswing Feb 2025

Extracellular Vesicles Released By All Patients Contain Hne-Adducted Proteins: Implications Of Collateral Damage., Jenni Ho, Suriyan Sukati, Tamara Taylor, Sherry Carter, Brittany Fuller, Amy Marmo, Caryn Sorge, John D'Orazio, D Allan Butterfield, Subbarao Bondada, Heidi Weiss, Daret K St Clair, Luksana Chaiswing

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Off-target neuronal injury is a serious side-effect observed in cancer survivors. It has previously been shown that pediatric acute lymphoblastic leukemia (ALL) survivors have a decline in neurocognition compared to healthy age-matched counterparts. Elevated oxidative stress has been documented to be a mediator in off-target tissue damage in cancer survivors. Early detection of oxidative stress markers may provide an opportunity to prevent off-target tissue damage. Extracellular vesicles (EVs) have surfaced as a potential diagnostic tool due to molecular cargo they contain. We investigated the potential for EVs to be a sensitive indicator of oxidative stress and off-target tissue damage by …


The Guardian The Month Of February 2025, Wright State Student Body Feb 2025

The Guardian The Month Of February 2025, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the Month of February 2025. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.


Ipulse - February 2025, Lynn University Feb 2025

Ipulse - February 2025, Lynn University

Student Newspapers

Issues:

  • February 2025 - Volume 1
  • February 2025 - Volume 2
  • February 2025 - Volume 3


Analysis Of 26 Studies Of The Impact Of Coconut Oil On Lipid Parameters: Beyond Total And Ldl Cholesterol, Mary T. Newport, Fabian M. Dayrit Feb 2025

Analysis Of 26 Studies Of The Impact Of Coconut Oil On Lipid Parameters: Beyond Total And Ldl Cholesterol, Mary T. Newport, Fabian M. Dayrit

Chemistry Faculty Publications

Coconut oil (CNO) is often characterized as an “artery-clogging fat” because it is a predominantly saturated fat that ostensibly raises total cholesterol (TChol) and LDL cholesterol (LDL-C). Whereas previous analyses assessed CNO based on the relative effects on lipid parameters against other fats and oils, this analysis focuses on the effects of CNO itself. Here, we review the literature on CNO and analyze 984 lipid profile data sets from 26 CNO studies conducted over the past 40 years. This analysis shows considerable heterogeneity among CNO studies regarding participant selection, the amount consumed, and the study duration. The analysis reveals that, …


Multi-Institutional Retrospective Study On Opioid Prescribing Patterns Of Oral And Maxillofacial Surgeons, Steven J D Zbarsky, Issa A Hanna, Je Dong Ryu, Audra Boehm, Simon Young, Gary Yu, Minh Phuong Dong, Minh Chau Joe Tran, Alan Herford, Samuel Young, Chi T Viet Feb 2025

Multi-Institutional Retrospective Study On Opioid Prescribing Patterns Of Oral And Maxillofacial Surgeons, Steven J D Zbarsky, Issa A Hanna, Je Dong Ryu, Audra Boehm, Simon Young, Gary Yu, Minh Phuong Dong, Minh Chau Joe Tran, Alan Herford, Samuel Young, Chi T Viet

Faculty, Staff and Student Publications

BACKGROUND: The opioid epidemic is a serious crisis in the United States. It has been proposed that opioid prescriptions after dental procedures are a major contributor to opioid use and abuse. The American Dental Association has been working to educate dental care providers about safe opioid prescribing practices. The authors hypothesized that oral and maxillofacial surgeons, following the efforts and publications from the American Dental Association, have been prescribing fewer postoperative opioids.

METHODS: This was a multi-institutional retrospective study with a total of 3,710 patients from Loma Linda University and University of Texas Health Science Center at Houston undergoing ambulatory …


The 2024 Whippoorwill Award: Gathering Stories Of Indigeneity, Connection, And Belonging, Erika L. Bass, Michael J. Young, Alan Hoffman, Jacqueline Yahn, Monica Roe, Devon Brenner, Chea Parton Feb 2025

The 2024 Whippoorwill Award: Gathering Stories Of Indigeneity, Connection, And Belonging, Erika L. Bass, Michael J. Young, Alan Hoffman, Jacqueline Yahn, Monica Roe, Devon Brenner, Chea Parton

The Rural Educator

No abstract provided.


Silver Tsunami Or Silver Rush? Extracting Value From Elders, Andrew Milne Feb 2025

Silver Tsunami Or Silver Rush? Extracting Value From Elders, Andrew Milne

Suffolk University Law School Faculty Works

I examine how the United States finances elder care, arguing that the legal processes structuring elder care tend to widen economic inequality and divide the interests of lower-income people against each other along generational, gendered, and racialized lines. I begin with two case narratives drawn from my practice experience as a poverty lawyer for older adults. One narrative involves an elder homeowner, while the other involves an elder renter. Both face crises of unmet care needs, the threat of homelessness, and ultimately the outcome that many older people dread most: institutionalization in a nursing home. I use these narratives as …


The Mc4r Agonist, Setmelanotide, Is Associated With An Improvement In Hypercapnic Chemosensitivity And Weight Loss In Male Mice, Sarah N. Framnes-Deboer, Deanna M. Arble, Athena Rivera Feb 2025

The Mc4r Agonist, Setmelanotide, Is Associated With An Improvement In Hypercapnic Chemosensitivity And Weight Loss In Male Mice, Sarah N. Framnes-Deboer, Deanna M. Arble, Athena Rivera

Biological Sciences Faculty Research and Publications

Obesity increases the risk of respiratory diseases that reduce respiratory chemosensitivity, such as Obesity Hypoventilation Syndrome and sleep apnea. Recent evidence suggests that obesity-related changes in the brain, including alterations in melanocortin signaling via the melanocortin-4 receptor (MC4R), may underly altered chemosensitivity. Setmelanotide, an MC4R agonist, causes weight loss in both humans and animal models. However, it is unknown the extent to which setmelanotide affects respiratory chemosensitivity independent of body weight loss. The present study uses diet-induced obese, male C57bl/6 J mice to determine the extent to which acute setmelanotide treatment affects the hypercapnic ventilatory response (HCVR). We find that …


Frequency-Dependent Assembly Processes Determine The Coexistence And Relative Abundance Of Tropical Plant Species, David M. Defilippis, Joseph A. Lamanna, Stefan A. Schnitzer Feb 2025

Frequency-Dependent Assembly Processes Determine The Coexistence And Relative Abundance Of Tropical Plant Species, David M. Defilippis, Joseph A. Lamanna, Stefan A. Schnitzer

Biological Sciences Faculty Research and Publications

Testing the extent to which ecological communities are structured by deterministic (niche-based) assembly processes, resulting in predictable species abundance and composition, is a fundamental goal of ecology. Here we use a 10-year dataset of 55,156 lianas comprising 86 species in an old-growth tropical forest in Panama to test whether community assembly is consistent with niche-based assembly processes. We find that species diversity and community composition was maintained because species conformed to four general requirements of coexistence theory: (1) species have negative conspecific frequency-dependent feedback that control their local population size; (2) species have a stronger negative effect on their own …


Bioh 104n.01: Basic Human Biology, Kins W. Loree Feb 2025

Bioh 104n.01: Basic Human Biology, Kins W. Loree

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Bioh 105n.02: Basic Human Biology Laboratory, Kins W. Loree Feb 2025

Bioh 105n.02: Basic Human Biology Laboratory, Kins W. Loree

University of Montana Course Syllabi, 2021-2025

No abstract provided.